MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Papilledema

(UMLS:C0030353)

Definition:: Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)
UMLS ID:: C0030353
MeSH ID:: D010211

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.292.700.900

Classification 2:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.640.710

Synonym(s)

Papilledema

Blurring of optic disc

Blurring of optic disk

Choked disc

Choked disk

Edema of optic disc

OPTIC DISC EDEMA

Optic disc edema

Optic disc oedema

10.

Optic disc swelling

11.

Optic disc swollen

12.

Optic discs blurred

13.

Optic papillitis

14.

PAPILLEDEMA

15.

PAPILLITIS

16.

PAPILLOEDEMA

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acetazolamide	View details 7760885 12471353 12649241 18452541	CTD
2	Amiodarone	View details 2972746 3585402 3806132 3827710 10412703 11033139 11076348 12642303 12660594 15586652 15807838 16131795 17894292	CTD
3	Aspirin	3590391	CTD
4	Carboplatin	12483326	CTD
5	Carmustine	2956289	CTD
6	Chloroquine	7120869	CTD
7	Clindamycin	890588	CTD
8	Cocaine	1927636	CTD
9	Cytarabine	17209054 18575860	CTD
10	Danazol	2913802	CTD
11	Dexamethasone	18575860	CTD
12	Dextropropoxyphene	7114696	CTD
13	Doxycycline	12649241	CTD
14	Ergotamine	732190	CTD
15	Etoposide	3289726	CTD
16	Idarubicin	15045822	CTD
17	Isotretinoin	2931989 2973971 7634848	CTD
18	Ketoconazole	8333277 10172409	CTD
19	Linezolid	24088636	CTD
20	Lithium Carbonate	View details 670962 2497083 3921728 6777789 7962691	CTD
21	Medroxyprogesterone Acetate	2975585	CTD
22	Methotrexate	1568425 17209054	CTD
23	Minocycline	View details 624295 1421048 2534972 2977395 9457633 9683157 10632948 11491116 11680122 12038730 12471353 15184329	CTD
24	Nalidixic Acid	4583929 5313954 6025983	CTD
25	Nandrolone Decanoate	15579201	CTD
26	Nitroglycerin	1903583	CTD
27	Norethindrone Acetate	4714850	CTD
28	Norinyl	4413961	CTD
29	Omeprazole	9224084	CTD
30	Phenytoin	3951721	CTD
31	Prednisolone	7329884	CTD
32	Ribavirin	15459850	CTD
33	Sulfamethoxazole	5419321	CTD
34	Tamoxifen	16603470	CTD
35	Tetracycline	View details 859475 2937759 3225732 5039554 6449976 6780129 6788154 7634848 8056550 8507628 16136745	CTD
36	Tretinoin	View details 7905174 9028161 10466446 10742073 11215876 15045822 15863216 18452541 19018859	CTD
37	Tripelennamine	4227701	CTD
38	Vitamin A	View details 151668 4037599 4473880 5467368 6780129	CTD
39	Warfarin	4714850	CTD
40	carbidopa, levodopa drug combination	454080	CTD
41	chloroquine diphosphate	1232932	CTD
42	intetrix	6132067	CTD
43	liposomal amphotericin B	1299980	CTD
44	perhexiline maleate	View details 620132 6743625 7127202 7397053	CTD
45	reviparin	4714850	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Optic Atrophy	44.8%
2	Optic Neuritis	44.8%
3	Optic Neuropathy, Ischemic	36.1%
4	Anterior Ischemic Optic Neuropathy	36.1%
5	Ocular Motility Disorders	26.1%
6	Cyclophoria	26.1%
7	Low Tension Glaucoma	25.9%
8	Vagus Nerve Disorder	20.9%
9	Glossopharyngeal Neuralgia	20.9%
10	Abducens Nerve Diseases	20.9%
11	Trochlear Nerve Diseases	20.9%
12	Neuromyelitis Optica	17.5%
13	Strabismus	17.2%
14	Tolosa-Hunt Syndrome	17.2%
15	Ophthalmoplegic Migraine	16.4%
16	Duane Retraction Syndrome	16.1%
17	Facial Nerve Diseases	15.8%
18	Vestibulocochlear Nerve Diseases	15.5%
19	Optic Atrophy, Hereditary, Leber	15.2%
20	Olfactory Nerve Injuries	15%
21	Asthenopia	14.6%
22	Conjunctival Diseases	14.6%
23	Corneal Diseases	14.6%
24	Eyelid Diseases	14.6%
25	Lacrimal Apparatus Diseases	14.6%
26	Lens Diseases	14.6%
27	Ocular Hypertension	14.6%
28	Ocular Hypotension	14.6%
29	Retinal Diseases	14.6%
30	Scleral Diseases	14.6%
31	Vitreous Detachment	14.6%
32	Posterior Vitreous Detachment	14.6%
33	Optic Nerve Glioma	14.4%
34	Retinal Degeneration	14%
35	Ophthalmoplegia	13.6%
36	External Ophthalmoplegia	13.6%
37	Pupil Disorders	12.9%
38	Facial Nerve Injuries	12.9%
39	Esotropia	12.6%
40	Exotropia	12.6%
41	Demyelinating Diseases	12.2%
42	Demyelination	12.2%
43	Neuromuscular Diseases	12.2%
44	Chronobiology Disorders	12.2%
45	Xerophthalmia	12.1%
46	Iridocorneal endothelial syndrome	12.1%
47	Retinal Dysplasia	11.9%
48	Opsoclonus-Myoclonus Syndrome	11.6%
49	Miller Fisher Syndrome	11.3%
50	Vision Disorders	11.2%
51	Metamorphopsia	11.2%
52	Visual Impairment	11.2%
53	Blepharophimosis	11.1%
54	Uveal Neoplasms	11.1%
55	Eyelid Neoplasms	11%
56	Retinal Hemorrhage	11%
57	Eye Abnormalities	10.9%
58	Eye Infection	10.9%
59	Eye Manifestations	10.9%
60	Eye Neoplasms	10.9%
61	Aniridia	10.8%
62	Keratoconjunctivitis Sicca	10.7%
63	Progressive supranuclear palsy	10.6%
64	Motor Neuron Disease	10.5%
65	Corneal Scar	10.5%
66	Eye Injuries	10.4%
67	Congenital nystagmus	10.2%
68	Facial Neuralgia	10.2%
69	Keratoconjunctivitis	10.2%
70	Chorioretinitis	10.1%
71	Vestibular Neuronitis	10.1%
72	Multiple System Atrophy	9.6%
73	Corneal Ulcer	9.6%
74	Choroid Hemorrhage	9.5%
75	Color blindness	9.5%
76	Trauma, Nervous System	9.4%
77	Pars Planitis	9.4%
78	Angioid Streaks	9.3%
79	Anisometropia	9.3%
80	Aphakia	9.3%
81	Astigmatism	9.3%
82	Blepharitis	9.3%
83	Blepharoptosis	9.3%
84	Blepharospasm	9.3%
85	Choroid Diseases	9.3%
86	Conjunctivitis	9.3%
87	Corneal edema	9.3%
88	Corneal Opacity	9.3%
89	Dacryocystitis	9.3%
90	Dry Eye Syndromes	9.3%
91	Ectropion	9.3%
92	Enophthalmos	9.3%
93	Entropion	9.3%
94	Episcleritis	9.3%
95	Exophthalmos	9.3%
96	Glaucoma	9.3%
97	Iris Diseases	9.3%
98	Keratitis	9.3%
99	Keratoconus	9.3%
100	Lacrimal Duct Obstruction	9.3%
101	Lens dislocation	9.3%
102	Lens Subluxation	9.3%
103	Mydriasis	9.3%
104	Myopia	9.3%
105	Presbyopia	9.3%
106	Pterygium	9.3%
107	Retinal Detachment	9.3%
108	Retinitis	9.3%
109	Scleritis	9.3%
110	Uveitis	9.3%
111	Corneal Neovascularization	9.3%
112	Orbital Pseudotumor	9.3%
113	Cataract	9.3%
114	Pinguecula	9.3%
115	Trichiasis	9.3%
116	Stiff-Person Syndrome	9.2%
117	Nervous System Neoplasms	9.1%
118	Neurologic Manifestations	9.1%
119	Neurotoxicity Syndromes	9.1%
120	Retinitis Pigmentosa	8.8%
121	Pigmentary retinopathy	8.8%
122	Choroiditis	8.8%
123	Iridocyclitis	8.8%
124	Iritis	8.8%
125	Encephalomyelitis	8.6%
126	Prion Diseases	8.6%
127	Autonomic Dysreflexia	8.6%
128	Complex Regional Pain Syndromes	8.6%
129	Polyradiculoneuropathy	8.6%
130	Polyradiculoneuritis	8.6%
131	Eye Hemorrhage	8.5%
132	Amblyopia	8.4%
133	Horner Syndrome	8.4%
134	Restless Legs Syndrome	8.3%
135	Facial Hemiatrophy	8.2%
136	Melkersson-Rosenthal Syndrome	8.2%
137	Uveomeningoencephalitic Syndrome	8.2%
138	Anisocoria	8.2%
139	Tonic Pupil	8.2%
140	Spinal Muscular Atrophy	8.1%
141	Progressive Muscular Atrophy	8.1%
142	Hordeolum	7.9%
143	Corneal Perforation	7.9%
144	Vocal Cord Paralysis	7.8%
145	Meningoencephalitis	7.8%
146	Subacute Combined Degeneration	7.8%
147	Parkinson Disease	7.7%
148	Marchiafava-Bignami Disease	7.7%
149	Amyotrophic Lateral Sclerosis	7.7%
150	Trigeminal Nerve Disorder	7.5%
151	Orbital Myositis	7.5%
152	Trachoma	7.4%
153	Diplopia	7.4%
154	Scotoma	7.4%
155	Photophobia	7.4%
156	Amaurosis	7.4%
157	Blindness	7.4%
158	Retinoblastoma	7.4%
159	Sleep Wake Disorders	7.4%
160	Acoustic Neuroma	7.2%
161	Spinal Cord Injuries	7.1%
162	Brain Diseases	7%
163	Dysautonomia	7%
164	Meningitis	7%
165	Movement Disorders	7%
166	Pachymeningitis	7%
167	Spinal Cord Diseases	7%
168	Heavy Metal Poisoning, Nervous System	7%
169	Neuromuscular Junction Diseases	7%
170	Tauopathies	7%
171	Peripheral Nervous System Diseases	7%
172	Peripheral Nerve Injuries	6.9%
173	Lewy Body Disease	6.9%
174	Anophthalmos	6.9%
175	Endophthalmitis	6.9%
176	Microphthalmos	6.9%
177	Pemphigoid, Benign Mucous Membrane	6.9%
178	Retinal Artery Occlusion	6.9%
179	Retinopathy of Prematurity	6.9%
180	Orbital Cellulitis	6.9%
181	Retinal Vasculitis	6.9%
182	Hypertensive Retinopathy	6.9%
183	Retrobulbar Hemorrhage	6.9%
184	Corneal Endothelial Cell Loss	6.9%
185	Guillain-Barre Syndrome	6.9%
186	Striatonigral Degeneration	6.9%
187	Myasthenia Gravis	6.8%
188	Asterixis	6.8%
189	Ballismus	6.8%
190	Hyphema	6.8%
191	Retinal Neovascularization	6.8%
192	Vitreous Hemorrhage	6.8%
193	Acanthamoeba Keratitis	6.8%
194	Angle Closure Glaucoma	6.8%
195	Glaucoma, Open-Angle	6.8%
196	Macular degeneration	6.8%
197	Panuveitis	6.8%
198	Retinal Drusen	6.8%
199	Retinal Necrosis Syndrome, Acute	6.8%
200	Retinoschisis	6.8%
201	Exfoliation Syndrome	6.8%
202	Mobius Syndrome	6.8%
203	Bell Palsy	6.8%
204	Keratitis, Herpetic	6.8%
205	Myelitis	6.8%
206	Progressive bulbar palsy	6.8%
207	Cytomegalovirus Retinitis	6.8%
208	Bulbar palsy	6.8%
209	Herpes Zoster Oticus	6.8%
210	Dandy-Walker Syndrome	6.7%
211	Bacterial conjunctivitis	6.7%
212	Pneumocephalus	6.7%
213	Poliomyelitis	6.7%
214	Causalgia	6.7%
215	Trigeminal Neuralgia	6.2%
216	Leukoencephalitis, Acute Hemorrhagic	6.1%
217	Neuroleptic Malignant Syndrome	6.1%
218	Myelinolysis, Central Pontine	6.1%
219	Epidural Abscess	6.1%
220	MPTP Poisoning	6%
221	Hemianopsia	6%
222	Myelitis, Transverse	6%
223	Kearns-Sayre syndrome	6%
224	Chronic Fatigue Syndrome	6%
225	Shy-Drager Syndrome	5.9%
226	Lambert-Eaton Myasthenic Syndrome	5.9%
227	Reflex Sympathetic Dystrophy	5.9%
228	Subdural Effusion	5.9%
229	Parkinsonian Disorders	5.9%
230	Nocturnal Myoclonus Syndrome	5.9%
231	Sleep Disorders, Circadian Rhythm	5.9%
232	Encephalomyelitis, Acute Disseminated	5.8%
233	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.8%
234	Botulism	5.6%
235	Central Nervous System Cysts	5.6%
236	Amaurosis Fugax	5.6%
237	Blindness, Cortical	5.6%
238	Anterior uveitis	5.6%
239	Uveitis, Posterior	5.6%
240	Dystonia Musculorum Deformans	5.6%
241	Dyskinesia, Drug-Induced	5.5%
242	Retinal Vein Occlusion	5.5%
243	Central Nervous System Infection	5.5%
244	Myopathy	5.5%
245	Diabetic Retinopathy	5.4%
246	Eye pain	5.4%
247	Panophthalmitis	5.4%
248	Brain Injuries	5.4%
249	Brain Neoplasms	5.4%
250	Multiple Sclerosis	5.4%
251	Spinal Cord Neoplasms	5.4%
252	Craniocerebral Trauma	5.3%
253	Parasomnia	5.3%
254	Dyssomnias	5.3%
255	Decerebrate State	5.2%
256	Hemiparesis	5.2%
257	Hydranencephaly	5.2%
258	Meningism	5.2%
259	Neural Tube Defects	5.2%
260	Paresis	5.2%
261	Seizures	5.2%
262	Sensation Disorders	5.2%
263	Tethered Cord Syndrome	5.2%
264	Central Nervous System Neoplasms	5.2%
265	Complex partial seizures	5.2%
266	Iniencephaly	5.2%
267	Craniorachischisis	5.2%
268	Exencephaly	5.2%
269	Monoparesis	5.2%
270	Septo-Optic Dysplasia	5.2%
271	Cortical Dysplasia	5.2%
272	Neurogenic Inflammation	5.2%
273	Gait Disorders, Neurologic	5.2%
274	Neuromuscular Manifestations	5.2%
275	Malformations of Cortical Development	5.2%
276	Sweating, Gustatory	5.1%
277	Auriculotemporal Syndrome	5.1%
278	Aicardi's syndrome	5.1%
279	Choroidal Neovascularization	5%
280	Meige Syndrome	5%
281	Brachial Plexus Neuritis	5%
282	Neuralgic Amyotrophy	5%
283	Cerebral Ventriculitis	5%
284	Leukoencephalopathy, Progressive Multifocal	5%
285	Epilepsy, Post-Traumatic	4.9%
286	Akathisia, Drug-Induced	4.9%
287	Scrapie	4.8%
288	Central Cord Syndrome	4.8%
289	Limbic Encephalitis	4.7%
290	Presenile dementia	4.7%
291	Senile dementia	4.7%
292	Meningitis, Bacterial	4.7%
293	Meningitis, Fungal	4.7%
294	Chorea	4.7%
295	Acrodynia	4.7%
296	Alstrom Syndrome	4.6%
297	Huntington Disease	4.6%
298	Tarsal Tunnel Syndrome	4.6%
299	Cauda Equina Syndrome	4.6%
300	Posterior Leukoencephalopathy Syndrome	4.6%
301	Posterior reversible encephalopathy syndrome	4.6%
302	Akinetic Mutism	4.5%
303	Anoxic Encephalopathy	4.5%
304	Arachnoiditis	4.5%
305	Basal Ganglia Diseases	4.5%
306	Brain Damage, Chronic	4.5%
307	Cerebellar Diseases	4.5%
308	Encephalitis	4.5%
309	Encephalomalacia	4.5%
310	Epilepsy	4.5%
311	Hydrocephalus	4.5%
312	Congenital Hydrocephalus	4.5%
313	Hypothalamic Diseases	4.5%
314	Aseptic Meningitis	4.5%
315	Neuritis	4.5%
316	Polyneuritis	4.5%
317	Radiculitis	4.5%
318	Syringomyelia	4.5%
319	Thalamic Diseases	4.5%
320	Intracranial Hypertension	4.5%
321	Polyneuropathy	4.5%
322	Mononeuritis	4.5%
323	Aura	4.5%
324	Leukoencephalopathy	4.5%
325	Essential Tremor	4.5%
326	Neuroaxonal Dystrophies	4.5%
327	Familial Tremor	4.5%
328	Headache Disorders	4.5%
329	Mononeuropathies	4.5%
330	Intracranial Hypotension	4.5%
331	Brachial Plexus Neuropathies	4.5%
332	Radiculopathy	4.5%
333	Mononeuropathy Multiplex	4.5%
334	Nerve Root Compression	4.5%
335	Myasthenia Gravis, Autoimmune, Experimental	4.5%
336	Brain Edema	4.5%
337	Brain Hypoxia	4.5%
338	Aqueductal Stenosis	4.5%
339	Pneumorrhachis	4.5%
340	Writer's Cramp	4.5%
341	Lafora Disease	4.5%
342	Unverricht-Lundborg Syndrome	4.5%
343	Brain Abscess	4.5%
344	Charcot-Marie-Tooth Disease	4.5%
345	Lupus Vasculitis, Central Nervous System	4.4%
346	Cerebellar Neoplasms	4.4%
347	Vasculitis, Central Nervous System	4.3%
348	Jet Lag Syndrome	4.3%
349	Neurobehavioral Manifestations	4.3%
350	Brain Death	4.2%
351	Coma, Post-Head Injury	4.2%
352	Canavan Disease	4.2%
353	Alexander Disease	4.2%
354	Paraneoplastic Encephalomyelitis	4.2%
355	Myoclonic Epilepsy	4.1%
356	Epilepsy, Temporal Lobe	4.1%
357	Ophthalmia Neonatorum	4.1%
358	Epilepsy, Rolandic	4.1%
359	Benign Rolandic Epilepsy	4.1%
360	CHARGE Syndrome	4.1%
361	Sturge-Weber Syndrome	4.1%
362	Vertigo	4.1%
363	Alcohol-Induced Disorders, Nervous System	4.1%
364	Dementia, Vascular	4.1%
365	Brain Hemorrhage, Traumatic	4.1%
366	Herpes Zoster Ophthalmicus	4.1%
367	Tuberous Sclerosis	4%
368	Friedreich Ataxia	4%
369	Creutzfeldt-Jakob disease	4%
370	Basal Ganglia Cerebrovascular Disease	4%
371	Brain Injuries, Diffuse	4%
372	Traumatic Brain Injury	4%
373	Cerebellar Ataxia	4%
374	Supratentorial Neoplasms	4%
375	Torticollis	4%
376	Multiple Sclerosis, Chronic Progressive	4%
377	Multiple Sclerosis, Relapsing-Remitting	4%
378	Ataxia Telangiectasia	4%
379	Myotonia Congenita	3.9%
380	Paraneoplastic Cerebellar Degeneration	3.9%
381	Cerebrospinal Fluid Otorrhea	3.9%
382	Cerebrospinal Fluid Rhinorrhea	3.9%
383	Neuritis, Autoimmune, Experimental	3.9%
384	Gait Ataxia	3.9%
385	Tuberculosis, Meningeal	3.7%
386	Carotid Artery Injuries	3.7%
387	Juvenile Myoclonic Epilepsy	3.7%
388	Myoclonic Epilepsies, Progressive	3.7%
389	Carpal Tunnel Syndrome	3.7%
390	Vascular Headaches	3.7%
391	neurofibroma	3.6%
392	Hypoxia-Ischemia, Brain	3.6%
393	Sciatica	3.6%
394	Tardive Dyskinesia	3.6%
395	Persistent Vegetative State	3.6%
396	Myotonic Dystrophy	3.5%
397	Voice Disorders	3.5%
398	Voice Disturbance	3.5%
399	Brain Diseases, Metabolic	3.4%
400	Cerebrovascular Disorders	3.4%
401	Myositis	3.4%
402	Cerebrovascular Insufficiency	3.4%
403	Isaacs syndrome	3.4%
404	Arsenic Poisoning	3.4%
405	Dementia	3.4%
406	Myotonic Disorders	3.4%
407	Central Nervous System Fungal Infections	3.4%
408	Conus Medullaris Syndrome	3.4%
409	Myasthenic Syndromes, Congenital	3.4%
410	Spinal Cord Vascular Diseases	3.4%
411	Hepatolenticular Degeneration	3.4%
412	Graves Disease	3.4%
413	Smith-Magenis syndrome	3.4%
414	Diabetic Neuropathies	3.4%
415	Facial Injuries	3.4%
416	Diabetic Amyotrophy	3.4%
417	Diabetic Autonomic Neuropathy	3.4%
418	Sleep Talking	3.4%
419	Manganese Poisoning	3.4%
420	Dural Arteriovenous Fistula	3.4%
421	Sleep Disorders, Intrinsic	3.4%
422	Orthostatic intolerance	3.4%
423	Cerebral Palsy	3.4%
424	Epilepsies, Partial	3.4%
425	Epilepsy, Generalized	3.4%
426	Pseudotumor Cerebri	3.4%
427	Sciatic Neuropathy	3.4%
428	Hypertensive Encephalopathy	3.4%
429	Ulnar Neuropathies	3.4%
430	Lesion of Sciatic Nerve	3.4%
431	Simple Partial Seizures	3.4%
432	Epilepsy, Reflex	3.4%
433	Ulnar Neuritis	3.4%
434	Radial nerve compression	3.4%
435	Radial Tunnel Syndrome	3.4%
436	Peroneal Neuropathies	3.4%
437	Radial Neuropathy	3.4%
438	Median Neuropathy	3.4%
439	Sciatic Nerve Palsy	3.4%
440	Femoral Neuropathy	3.4%
441	Tibial Neuropathy	3.4%
442	Ulnar Nerve Palsy	3.4%
443	Alice in Wonderland Syndrome	3.4%
444	Postural Orthostatic Tachycardia Syndrome	3.4%
445	Radial nerve palsy	3.4%
446	Headache Disorders, Primary	3.4%
447	Headache Disorders, Secondary	3.4%
448	Medication overuse headache	3.4%
449	Anosmia	3.4%
450	Ataxia	3.4%
451	Athetosis	3.4%
452	Catalepsy	3.4%
453	Dystonia	3.4%
454	Hemiplegia	3.4%
455	Locked-In Syndrome	3.4%
456	Meningeal Neoplasms	3.4%
457	Meningomyelocele	3.4%
458	Muscle Hypertonia	3.4%
459	Muscle hypotonia	3.4%
460	Myoclonus	3.4%
461	Myotonia	3.4%
462	Neuralgia	3.4%
463	Paraplegia	3.4%
464	Pseudobulbar Palsy	3.4%
465	Quadriplegia	3.4%
466	Spasm	3.4%
467	Spastic Paraplegia	3.4%
468	Status Epilepticus	3.4%
469	Taste Disorders	3.4%
470	Tremor	3.4%
471	Spina Bifida	3.4%
472	Monoplegia	3.4%
473	Hypokinesia	3.4%
474	Paraparesis	3.4%
475	Bradykinesia	3.4%
476	Waxy flexibility	3.4%
477	Action Tremor	3.4%
478	Resting Tremor	3.4%
479	Dysosmia	3.4%
480	Quadriparesis	3.4%
481	Mercury Poisoning, Nervous System	3.4%
482	Olfaction Disorders	3.4%
483	Myokymia	3.4%
484	Lead Poisoning, Nervous System	3.4%
485	Somatosensory Disorders	3.4%
486	Neuropathic pain	3.4%
487	Hyperkinesia	3.4%
488	Intention tremor	3.4%
489	Leukomalacia, Periventricular	3.3%
490	Alcohol Withdrawal Seizures	3.3%
491	Akathisia	3.3%
492	Restlessness	3.3%
493	Psychomotor Agitation	3.3%
494	Mandibulofacial Dysostosis	3.3%
495	Cubital Tunnel Syndrome	3.3%
496	Diffuse Axonal Injury	3.3%
497	Brain Stem Neoplasms	3.3%
498	Brain Concussion	3.3%
499	Pituitary Adenoma	3.1%
500	Pituitary Neoplasms	3.1%
501	Toxoplasmosis, Cerebral	3.1%
502	Vertebral Artery Dissection	3.1%
503	Amnesia, Transient Global	3.1%
504	Gait Apraxia	3%
505	Meningitis, Cryptococcal	3%
506	Meningitis, Listeria	3%
507	Refsum Disease	3%
508	Meningitis, Haemophilus	3%
509	Meningitis, Pneumococcal	3%
510	Frontotemporal dementia	3%
511	Albinism	3%
512	Basal Ganglia Hemorrhage	2.9%
513	Choroid Plexus Papilloma	2.9%
514	Reflex, Abnormal	2.9%
515	Hyporeflexia	2.9%
516	Hyperreflexia	2.9%
517	Hand-Arm Vibration Syndrome	2.9%
518	Mitochondrial Encephalomyopathies	2.8%
519	Polyradiculopathy	2.8%
520	Post-Traumatic Headache	2.8%
521	Tension Headache	2.8%
522	Epilepsy, Complex Partial	2.8%
523	Migraine Disorders	2.8%
524	Abdominal Migraine	2.8%
525	Status Migrainosus	2.8%
526	Cervicogenic Headache	2.8%
527	Fibromyalgia	2.8%
528	Pituitary Apoplexy	2.8%
529	Central Nervous System Bacterial Infections	2.8%
530	Medial Tibial Stress Syndrome	2.8%
531	Brain Contusion	2.7%
532	Mitochondrial Myopathies	2.7%
533	Brain Infarction	2.7%
534	Confusion	2.7%
535	Facial paralysis	2.7%
536	Lethargy	2.7%
537	Memory Disorders	2.7%
538	Muscle Cramp	2.7%
539	Perceptual Disorders	2.7%
540	Psychomotor Disorders	2.7%
541	Eosinophilia-Myalgia Syndrome	2.7%
542	Anhedonia	2.7%
543	Disorientation	2.7%
544	Facial Paresis	2.7%
545	Memory Loss	2.7%
546	Hemisensory Neglect	2.7%
547	Dysacusis	2.7%
548	Subarachnoid Hemorrhage, Traumatic	2.7%
549	Sleep Bruxism	2.7%
550	Carotid Artery, Internal, Dissection	2.7%
551	Anencephaly	2.7%
552	Meningocele	2.7%
553	Muscular Atrophy	2.7%
554	Respiratory Paralysis	2.7%
555	Encephalocele	2.7%
556	Subacute Sclerosing Panencephalitis	2.7%
557	Putaminal Hemorrhage	2.7%
558	Tetany	2.7%
559	Pituitary Diseases	2.7%
560	Infarction, Middle Cerebral Artery	2.6%
561	Infarction, Anterior Cerebral Artery	2.6%
562	Infarction, Posterior Cerebral Artery	2.6%
563	Thoracic Outlet Syndrome	2.6%
564	Classical Lissencephalies and Subcortical Band Heterotopias	2.6%
565	Amyloid Neuropathies, Familial	2.6%
566	Carotid Artery Diseases	2.5%
567	Brain Ischemia	2.5%
568	Hypotension, Orthostatic	2.5%
569	Sleep Apnea Syndromes	2.5%
570	Cerebrovascular accident	2.5%
571	Polymyositis	2.5%
572	Kluver-Bucy Syndrome	2.5%
573	Vasospasm, Intracranial	2.5%
574	Spinal Cord Ischemia	2.5%
575	Intracranial Arterial Diseases	2.5%
576	Post-Exercise Hypotension	2.5%
577	Cluster Headache	2.5%
578	Migraine with Aura	2.5%
579	Familial Hemiplegic Migraine	2.5%
580	Chronic Paroxysmal Hemicrania	2.5%
581	SUNCT Syndrome	2.5%
582	Paroxysmal Hemicrania	2.5%
583	Disorders of Excessive Somnolence	2.5%
584	Sleep Initiation and Maintenance Disorders	2.5%
585	Night Terrors	2.5%
586	Somnambulism	2.5%
587	Transient Insomnia	2.5%
588	Sleep Paralysis	2.5%
589	Chronic Insomnia	2.5%
590	REM Sleep Behavior Disorder	2.5%
591	Hypersomnia	2.5%
592	Dermal Sinus	2.5%
593	Dysgeusia	2.5%
594	Formication	2.5%
595	Hyperalgesia	2.5%
596	Hyperesthesia	2.5%
597	Hypesthesia	2.5%
598	Language Disorders	2.5%
599	Numbness	2.5%
600	Paresthesia	2.5%
601	Paraparesis, Spastic	2.5%
602	Spina Bifida Cystica	2.5%
603	Trismus	2.5%
604	Spina Bifida Occulta	2.5%
605	Epilepsia Partialis Continua	2.5%
606	Sicca Syndrome	2.5%
607	Hypogeusia	2.5%
608	Meningeal Carcinomatosis	2.5%
609	Brown-Sequard Syndrome	2.5%
610	Lissencephaly	2.5%
611	Polymicrogyria	2.5%
612	Pachygyria	2.5%
613	Schizencephaly	2.5%
614	Lockjaw	2.5%
615	Allodynia	2.5%
616	Lead Poisoning, Nervous System, Childhood	2.5%
617	Lead Poisoning, Nervous System, Adult	2.5%
618	Sjogren's Syndrome	2.5%
619	Periventricular Nodular Heterotopia	2.5%
620	Ageusia	2.5%
621	Tuberculosis, Central Nervous System	2.5%
622	Auditory Perceptual Disorders	2.5%
623	Adrenoleukodystrophy	2.5%
624	Cerebral Infarction	2.4%
625	Brain Stem Infarctions	2.4%
626	Giant Cell Arteritis	2.4%
627	Temporal Arteritis	2.4%
628	Alexia	2.3%
629	Dyslexia	2.3%
630	Lateral Medullary Syndrome	2.3%
631	Consciousness Disorders	2.3%
632	Mental Retardation	2.3%
633	Muscle Weakness	2.3%
634	Depressed Level of Consciousness	2.3%
635	Mental deficiency	2.3%
636	Intellectual Disability	2.3%
637	Catatonia	2.3%
638	Familial Periodic Paralysis	2.2%
639	Aphonia	2.2%
640	Sleep Deprivation	2.2%
641	Dysphonia	2.2%
642	Moyamoya Disease	2.2%
643	MELAS Syndrome	2.2%
644	Neurofibrosarcoma	2.2%
645	West Nile Fever	2.2%
646	Hematoma, Subdural	2.1%
647	Hematoma, Epidural, Cranial	2.1%
648	Empty Sella Syndrome	2.1%
649	Hyperpituitarism	2.1%
650	Hypopituitarism	2.1%
651	Hypophysitis	2.1%
652	Cerebral Arterial Diseases	2.1%
653	Vertebrobasilar Insufficiency	2.1%
654	Anterior Spinal Artery Syndrome	2.1%
655	Basilar Artery Stenosis	2.1%
656	Vertebral Artery Stenosis	2.1%
657	Sleep Apnea, Obstructive	2.1%
658	Sleep Apnea, Central	2.1%
659	Intracranial Hemorrhage, Hypertensive	2.1%
660	Transient Cerebral Ischemia	2.1%
661	Narcolepsy	2.1%
662	Kleine-Levin Syndrome	2.1%
663	Agraphia	2.1%
664	Anomia	2.1%
665	Cluttering	2.1%
666	Language Development Disorders	2.1%
667	Speech Disorders	2.1%
668	Syncope	2.1%
669	Stupor	2.1%
670	Dysgraphia	2.1%
671	Presyncope	2.1%
672	Dyslalia	2.1%
673	Muscular Dystrophy	2%
674	Muscle Rigidity	2%
675	Muscle Spasticity	2%
676	Cogwheel Rigidity	2%
677	Hemifacial Spasm	2%
678	Nuchal Rigidity	2%
679	Reye Syndrome	2%
680	Neuroaspergillosis	2%
681	Pyomyositis	2%
682	Intracranial Embolism and Thrombosis	2%
683	Hepatic Encephalopathy	2%
684	Agnosia	2%
685	Apraxias	2%
686	Hallucinations	2%
687	Hyperacusis	2%
688	Tinnitus	2%
689	Visual Agnosia	2%
690	Anosognosia	2%
691	Wernicke-Korsakoff Syndrome	2%
692	Phonophobia	2%
693	Hearing Loss	2%
694	Sarcopenia	2%
695	Myalgia	1.9%
696	Behcet Syndrome	1.9%
697	Neuronal Ceroid-Lipofuscinoses	1.9%
698	Hyperprolactinemia	1.9%
699	Hematoma, Subdural, Intracranial	1.9%
700	Hematoma, Subdural, Chronic	1.9%
701	Hematoma, Subdural, Acute	1.9%
702	Subclavian Steal Syndrome	1.9%
703	Pick Disease of the Brain	1.9%
704	Cataplexy	1.9%
705	Aphasia	1.8%
706	Articulation Disorders	1.8%
707	Echolalia	1.8%
708	Stuttering	1.8%
709	Dysphasia	1.8%
710	Pseudorabies	1.8%
711	Dysarthria	1.7%
712	Hoarseness	1.7%
713	Toxoplasmosis, Congenital	1.7%
714	Amnesia	1.7%
715	Delirium	1.7%
716	Dissociative Amnesia	1.7%
717	Global Amnesia	1.7%
718	Eye Burns	1.7%
719	Cri-du-Chat Syndrome	1.7%
720	Down Syndrome	1.7%
721	Brain Diseases, Metabolic, Inborn	1.7%
722	Trisomy 21	1.7%
723	Cockayne Syndrome	1.7%
724	Malaria, Cerebral	1.7%
725	POEMS Syndrome	1.7%
726	Alcohol Withdrawal Delirium	1.7%
727	Meningioma	1.7%
728	Williams Syndrome	1.7%
729	Carotid Stenosis	1.7%
730	Intracranial Aneurysm	1.7%
731	Welander Distal Myopathy	1.7%
732	Neurocysticercosis	1.7%
733	Microcephaly	1.7%
734	Macrocephaly	1.7%
735	Dyscalculia	1.7%
736	Intracranial Arteriosclerosis	1.7%
737	Cerebral Atherosclerosis	1.7%
738	Rett Syndrome	1.7%
739	Subarachnoid Hemorrhage	1.7%
740	Cerebral Arteriosclerosis	1.7%
741	Cerebral Hemorrhage	1.7%
742	Neurosyphilis	1.6%
743	Hypokalemic periodic paralysis	1.6%
744	Cerebral Thrombosis	1.6%
745	Intracranial Embolism	1.6%
746	Intracranial Thrombosis	1.6%
747	Deafness	1.6%
748	Hearing Loss, Sudden	1.6%
749	Gerstmann Syndrome	1.6%
750	Hearing Loss, Bilateral	1.6%
751	Hearing Loss, High-Frequency	1.6%
752	Hearing Loss, Mixed Conductive-Sensorineural	1.6%
753	Prosopagnosia	1.6%
754	Apraxia, Ideomotor	1.6%
755	Charles Bonnet Syndrome	1.6%
756	Hearing Loss, Unilateral	1.6%
757	Complete Hearing Loss	1.6%
758	Alien Hand Syndrome	1.6%
759	Deaf Mutism	1.6%
760	Porencephaly	1.6%
761	Mutism	1.5%
762	Selective Mutism	1.5%
763	Acromegaly	1.5%
764	Holoprosencephaly	1.5%
765	Cerebral Amyloid Angiopathy	1.5%
766	Sinus Thrombosis, Intracranial	1.5%
767	Prader-Willi Syndrome	1.4%
768	Wernicke Encephalopathy	1.4%
769	AIDS Dementia Complex	1.4%
770	Dermatomyositis	1.4%
771	Phantom pain	1.4%
772	Phantom Limb Pain	1.4%
773	Waterhouse-Friderichsen Syndrome	1.4%
774	Lyme Neuroborreliosis	1.4%
775	Alexia, Pure	1.4%
776	Muscular Dystrophy, Duchenne	1.4%
777	Cavernous Sinus Thrombosis	1.4%
778	Sagittal Sinus Thrombosis	1.4%
779	Retrograde amnesia	1.4%
780	Amnesia, Anterograde	1.4%
781	Carotid Artery Thrombosis	1.4%
782	Menkes Kinky Hair Syndrome	1.4%
783	Kernicterus	1.3%
784	Fragile X Syndrome	1.2%
785	Nelson Syndrome	1.2%
786	Rubinstein-Taybi Syndrome	1.1%
787	Prolactinoma	1.1%
788	Growth Hormone-Secreting Pituitary Adenoma	1.1%
789	Fabry Disease	1.1%
790	Galactosemias	1%
791	Urea Cycle Disorders, Inborn	1%
792	Tyrosinemias	1%
793	Homocystinuria	0.9%
794	Leigh Disease	0.9%
795	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.8%
796	Mucopolysaccharidosis II	0.8%
797	Glycogen storage disease type II	0.7%
798	Zellweger Syndrome	0.7%
799	Gaucher Disease	0.6%
800	Tay-Sachs Disease	0.6%
801	Niemann-Pick Disease, Type C	0.5%

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