MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypercholesterolemia

(UMLS:C0020443)

Definition:: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
UMLS ID:: C0020443
MeSH ID:: D006937

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.500.500.396

Synonym(s)

Hypercholesterolemia

Elevated total cholesterol

HYPERCHOLESTEREMIA

HYPERCHOLESTEROLAEMIA

HYPERCHOLESTEROLEMIA

High cholesterol

Hypercholesteremia

Hypercholesterolaemia

Hypercholesterolaemia, NOS

10.

Hypercholesterolemia, NOS

11.

Increased total cholesterol

12.

elevated cholesterol

13.

high blood cholesterol level

14.

hypercholesteraemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1-Naphthylisothiocyanate	27374722	CTD
2	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside	29064158	CTD
3	27-hydroxycholesterol	17873880	CTD
4	4-(4'-chlorobenzyloxy)benzyl nicotinate	4029807	CTD
5	8-epi-prostaglandin F2alpha	14602771	CTD
6	Acetylcysteine	20946910	CTD
7	Alcohols	31075344	CTD
8	Amiodarone	8137927 9751232	CTD
9	Atorvastatin	View details 11403364 11583720 12139858 12765306 12842237 12954916 17959387 18839266 20135644 20946910 24593216	CTD
10	Berberine	22342832	CTD
11	Bexarotene	21163938	CTD
12	Bezafibrate	View details 2045526 2492189 2643751 3760707 8017468 10780315 11164425 11545549 14602771 21703979	CTD
13	Bosentan	15486036	CTD
14	Caffeine	29800656 30825513	CTD
15	Calcium Carbonate	1456855	CTD
16	Capsaicin	16335782	CTD
17	Chlorogenic Acid	20696151	CTD
18	Chlorpromazine	11669021	CTD
19	Chlorprothixene	11669021	CTD
20	Chlorthalidone	6869207	CTD
21	Cholesterol	View details 8245718 16933029 17611329 21052790 21269478 21535835 22570273	CTD
22	Chromium	12487376	CTD
23	Clofibrate	1175893 7080553 7157849	CTD
24	Colestipol	2224231 2492189 8593127	CTD
25	Copper	12805251	CTD
26	Cyclosporine	9377752 10226898 11583721	CTD
27	Daunorubicin	2072310 4029807	CTD
28	Dexamethasone	15824971	CTD
29	Dextrothyroxine	934018 2492189 5818672	CTD
30	Doxazosin	12572707	CTD
31	Doxorubicin	View details 6416889 7913932 8255516 17550925 18218687 19018148 29064158	CTD
32	Enalapril	20847891	CTD
33	Estriol	2673747	CTD
34	Everolimus	10551636	CTD
35	Ezetimibe	15374793 17076980	CTD
36	Fatty Alcohols	19911216	CTD
37	Fenofibrate	View details 2045526 2492189 3760707 8457256 24593216	CTD
38	Fluvastatin	View details 8017468 8593127 10027656 10780315 12072574 16618834	CTD
39	Fructose	17883899 25169908 28257781	CTD
40	Gallic Acid	18571153	CTD
41	Gemfibrozil	View details 1521554 2067654 7670796 9678787	CTD
42	Grape Seed Extract	12836089	CTD
43	Indinavir	11545549 12473836	CTD
44	Linoleic Acid	18571153	CTD
45	Lisinopril	12566371	CTD
46	Losartan	8319760 18070995	CTD
47	Lovastatin	View details 1521554 1682723 1985608 2017280 2067654 2247468 2492189 2572816 2572817 3275891 3290520 7484806 7653497 7867482 7942524 8172444 8221476 8238075 8360706 8439902 8480959 8481075 8593127 8918723 8944218 9244616 9350151 9514463 10084510 10360474 10815931 11058722 12139858 12467231 12933658 12954916 17049607 19027590	CTD
48	MK-0524	21291812	CTD
49	Metformin	27551045	CTD
50	Methylprednisolone	2025290	CTD
51	Methylthiouracil	21269478	CTD
52	Mifepristone	27374722	CTD
53	Mitotane	1480741	CTD
54	Neomycin	2492189	CTD
55	Niacinamide	20696151	CTD
56	Niacin	View details 2054009 2492189 2929636 3174043 3275891 3680913 8124850 8593127 12487376 12788145 12804729 15342288 15808326 17611329 18471454 19166443 19911216 21291812	CTD
57	Nifedipine	10533616	CTD
58	Orlistat	11753595 15947531 15962606	CTD
59	Pectins	26070415	CTD
60	Penicillamine	8055207	CTD
61	Phytosterols	15808326	CTD
62	Pravastatin	View details 1682723 2492189 7909021 8172444 8238075 8593127 10027656 10751747 11189483 11770708 12409635 15199031 16029366 17188708 26875785	CTD
63	Prednisolone	15740732 17696277 19336998	CTD
64	Prednisone	2665233	CTD
65	Probenecid	5655316 5667986	CTD
66	Probucol	View details 2492189 8093399 8593127 9527400 22903822	CTD
67	Progesterone	2673747	CTD
68	Puromycin Aminonucleoside	View details 2236972 2267444 8319760 8648930 8822086 9399633 9527400 10468195 12269381 12836089 15740732 16574160 20540862	CTD
69	Puromycin	2025290	CTD
70	Pyridoxamine	19018148	CTD
71	Quercetin	21462320	CTD
72	Quetiapine Fumarate	20702477	CTD
73	Resveratrol	17188708 18426865 22607622	CTD
74	Ritonavir	11545549 12473836 17719200	CTD
75	Rosiglitazone	21269478	CTD
76	Rosuvastatin Calcium	15823640 15955130 16635810	CTD
77	Simvastatin	View details 1857844 1978916 2017280 2224231 2492189 2571051 7653497 7909021 8093380 8593127 9223394 9244616 9430375 9543095 9633944 10027656 10779001 11583721 14602771 15184351 15486036 15936011 17959387 18471454 24593216	CTD
78	Sirolimus	View details 10221490 12742468 16316336 18589147 19057397	CTD
79	Sodium Fluoride	24384758	CTD
80	Streptozocin	20696151 24815820 28178614	CTD
81	Tacrolimus	11443583 11583721 15982605	CTD
82	Thyroxine	11177166	CTD
83	Vitamin U	7195721	CTD
84	WEB 2086	2025290	CTD
85	YM 264	2025290	CTD
86	acipimox	10027656	CTD
87	arjunolic acid	18197399	CTD
88	bis(4-hydroxyphenyl)sulfone	27241191	CTD
89	bisphenol A	25168180	CTD
90	candoxatril	20847891	CTD
91	cerivastatin	12139858 15365880 18595439	CTD
92	chrysin	25169908	CTD
93	cilnidipine	19338138	CTD
94	ciprofibrate	2045526 2492189	CTD
95	fisetin	23524313	CTD
96	gamma-sitosterol	23287313	CTD
97	geraniol	28178614	CTD
98	gossypetin	25622137	CTD
99	lead nitrate	15475176 22293356	CTD
100	linalool	21944868	CTD
101	lupeol	16933029	CTD
102	oleuropein	18823963	CTD
103	perfluorooctanoic acid	25260175	CTD
104	platycodin D	16626693	CTD
105	potassium bromate	26296324	CTD
106	roquinimex	21195814	CTD
107	sodium arsenite	18197399 20946910	CTD
108	tetrahydrocurcumin	20696151	CTD
109	turmeric extract	18704882 21535835	CTD
110	tyloxapol	28411027	CTD
111	vanillin	26296324	CTD
112	zelandopam	15740732	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperlipoproteinemias	49.2%
2	Hypertriglyceridemia	49.2%
3	Hyperlipoproteinemia Type IV	32.5%
4	Hyperlipoproteinemia Type V	32.5%
5	Xanthomatosis	28.5%
6	Xanthoma	28.5%
7	Hyperlipidemia, Familial Combined	28.4%
8	Acid-Base Imbalance	22.7%
9	Calcium Metabolism Disorders	22.7%
10	Iron Metabolism Disorders	22.7%
11	Phosphorus Metabolism Disorders	22.7%
12	Water-Electrolyte Imbalance	22.7%
13	Mitochondrial Diseases	22.7%
14	Glucose Metabolism Disorders	22.7%
15	Hyperlipoproteinemia Type III	22.2%
16	Hypolipoproteinemias	21.7%
17	Lipodystrophy	20.6%
18	Wasting Syndrome	20.6%
19	Lipomatosis	19.6%
20	Hypercalcemia	16.4%
21	Hypocalcemia	16.4%
22	Milk-Alkali Syndrome	16.4%
23	Osteopenia	15.4%
24	Nutrition Disorders	15.3%
25	Brain Diseases, Metabolic	15.1%
26	Smith-Lemli-Opitz Syndrome	14.5%
27	Hypoalphalipoproteinemias	14.3%
28	Acidosis	12.2%
29	Alkalosis	12.2%
30	Amyloidosis	12.2%
31	Calcinosis	12.2%
32	Hyperglycemia	12.2%
33	Hyperinsulinism	12.2%
34	Hyperkalemia	12.2%
35	Hypernatremia	12.2%
36	Hypoglycemia	12.2%
37	Hypokalemia	12.2%
38	Hyponatremia	12.2%
39	Hypophosphatemia	12.2%
40	Metabolic acidosis	12.2%
41	Iron Overload	12.2%
42	Adiposis Dolorosa	11.4%
43	Pseudohypoparathyroidism	10.6%
44	Rickets	10.3%
45	Brain Diseases, Metabolic, Inborn	9.8%
46	Diabetes Mellitus	8.8%
47	Dehydration	8.4%
48	Water Intoxication	8.4%
49	Werner Syndrome	8.4%
50	Hyperhomocysteinemia	8.2%
51	Achlorhydria	8.2%
52	Amino Acid Metabolism, Inborn Errors	8.2%
53	Bloom Syndrome	8.2%
54	Carbohydrate Metabolism, Inborn Errors	8.2%
55	Metal Metabolism, Inborn Errors	8.2%
56	Osteoporosis	8.2%
57	Progeria	8.2%
58	Lysosomal Storage Diseases	8.2%
59	Bone Demineralization, Pathologic	8.2%
60	Cytochrome-c Oxidase Deficiency	8.2%
61	Peroxisomal Disorders	8.2%
62	Post-Traumatic Osteoporosis	8.2%
63	Celiac Disease	8.1%
64	Sprue, Tropical	8.1%
65	Steatorrhea	8.1%
66	Sprue	8.1%
67	Leigh Disease	7.8%
68	Lactose Intolerance	7.8%
69	Child Nutrition Disorders	7.6%
70	Hypervitaminosis A	7.6%
71	Infant Nutrition Disorders	7.6%
72	Malnutrition	7.6%
73	Neuronal Ceroid-Lipofuscinoses	7.3%
74	Acidosis, Lactic	7.2%
75	Calciphylaxis	7.2%
76	Hemosiderosis	7.2%
77	Ketosis	7.2%
78	Ketonuria	7.2%
79	Ketoacidosis	7.2%
80	Ketonemia	7.2%
81	Vascular calcification	7.2%
82	HIV-Associated Lipodystrophy Syndrome	6.9%
83	Carbamoyl-Phosphate Synthase I Deficiency Disease	6.6%
84	Mitochondrial Encephalomyopathies	6.5%
85	Mitochondrial Myopathies	6.3%
86	Myelinolysis, Central Pontine	6.2%
87	Galactosemias	6.2%
88	Urea Cycle Disorders, Inborn	6.2%
89	Tyrosinemias	6.2%
90	Osteomalacia	6.2%
91	Glycosuria	6.1%
92	Reye Syndrome	6.1%
93	Hepatic Encephalopathy	6.1%
94	Diabetic Ketoacidosis	6%
95	Congenital Hyperinsulinism	6%
96	HIV Wasting Syndrome	5.4%
97	Hyperphosphaturia	5.4%
98	Gaucher Disease	5%
99	Porphyrias, Hepatic	5%
100	Necrobiosis Lipoidica Diabeticorum	4.9%
101	Acidosis, Respiratory	4.9%
102	Alkalosis, Respiratory	4.9%
103	Homocystinuria	4.9%
104	Fanconi Anemia	4.9%
105	Renal tubular acidosis	4.8%
106	Alkaptonuria	4.8%
107	Glycogen Storage Disease	4.8%
108	Hypophosphatasia	4.8%
109	Insulin Resistance	4.8%
110	Osteoporosis, Postmenopausal	4.8%
111	Propionic acidemia	4.8%
112	Dihydropyrimidine Dehydrogenase Deficiency	4.8%
113	Cystinosis	4.8%
114	Familial Hypophosphatemic Rickets	4.5%
115	Wernicke Encephalopathy	4.4%
116	Sjogren-Larsson Syndrome	4.4%
117	Amyloid Neuropathies, Familial	4.2%
118	Glycogen storage disease type II	4.2%
119	Deficiency Diseases	4.1%
120	Starvation	4.1%
121	Refeeding Syndrome	4.1%
122	Friedreich Ataxia	4%
123	Zellweger Syndrome	4%
124	Menkes Kinky Hair Syndrome	4%
125	Fabry Disease	3.9%
126	Nesidioblastosis	3.9%
127	Renal Osteodystrophy	3.9%
128	Renal rickets	3.9%
129	MELAS Syndrome	3.8%
130	Gestational Diabetes	3.8%
131	Latent Autoimmune Diabetes in Adults	3.8%
132	Diabetes Mellitus, Experimental	3.7%
133	Adrenoleukodystrophy	3.7%
134	Hepatolenticular Degeneration	3.7%
135	Niemann-Pick Disease, Type C	3.6%
136	Nephrocalcinosis	3.6%
137	Tetany	3.6%
138	Refsum Disease	3.6%
139	Glycosuria, Renal	3.6%
140	Cerebral Amyloid Angiopathy	3.6%
141	Kernicterus	3.6%
142	Cockayne Syndrome	3.5%
143	Tay-Sachs Disease	3.5%
144	Mucopolysaccharidosis III	3.2%
145	Glycogen Storage Disease Type I	3.2%
146	Glycogen Storage Disease Type V	3.2%
147	Ataxia Telangiectasia	3.1%
148	Kearns-Sayre syndrome	3.1%
149	Optic Atrophy, Hereditary, Leber	3%
150	Familial Periodic Paralysis	3%
151	Primary amyloidosis	3%
152	Variegate Porphyria	2.9%
153	Acute intermittent porphyria	2.9%
154	Porphyria Cutanea Tarda	2.9%
155	Renal Aminoacidurias	2.9%
156	Fanconi Syndrome	2.9%
157	Pseudohypoaldosteronism	2.9%
158	Liddle Syndrome	2.9%
159	Xeroderma Pigmentosum	2.8%
160	Gout	2.5%
161	Amyotrophic Lateral Sclerosis	2.5%
162	Antley-Bixler Syndrome Phenotype	2.4%
163	Kwashiorkor	2.4%
164	Magnesium Deficiency	2.4%
165	Potassium Deficiency	2.4%
166	Protein Deficiency	2.4%
167	Avitaminosis	2.4%
168	Canavan Disease	2.1%
169	Alexander Disease	2.1%
170	Mucopolysaccharidosis II	2.1%
171	CREST Syndrome	2.1%
172	Hypokalemic periodic paralysis	1.9%
173	Frontotemporal dementia	1.9%
174	Cystinuria	1.9%
175	Albinism	1.9%
176	Arthritis, Gouty	1.6%
177	Obesity	1.6%
178	Ascorbic Acid Deficiency	1.6%
179	Vitamin A Deficiency	1.6%
180	Vitamin D Deficiency	1.6%
181	Vitamin E Deficiency	1.6%
182	Marasmus	1.6%
183	Ichthyosis, X-Linked	1.5%
184	Obesity, Abdominal	1.2%
185	Folic Acid Deficiency	1.2%
186	Pellagra	1.2%
187	Thiamine Deficiency	1.2%
188	Vitamin B 12 Deficiency	1.2%
189	Vitamin B 6 Deficiency	1.2%
190	Pyridoxine Deficiency	1.2%
191	Beriberi	1%
192	Pediatric Obesity	1%
193	Prader-Willi Syndrome	0.8%
194	Vitamin K Deficiency	0.8%
195	Anemia, Pernicious	0.7%
196	Scurvy	0.6%
197	Subacute Combined Degeneration	0.3%

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