MetaADEDB 2.0 @ LMMD
Keratoderma, Palmoplantar
(UMLS:C4551675)
Definition:
Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis).
UMLS ID:
C4551675
MeSH ID:
D007645
Classification 1:
Name:
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):
C16.320.850.475
Classification 2:
Name:
Skin and Connective Tissue Diseases
MeSH Tree Number(s):
C17.800.428.435|C17.800.827.475
Synonym(s)
1.
Keratoderma, Palmoplantar
2.
Hyperkeratosis of palms and soles
3.
Keratoderma palmaris et plantaris
4.
Keratosis palmaris et plantaris
5.
Palmar and plantar keratoderma
6.
Palmoplantar Keratoderma
7.
Palmoplantar keratoderma
8.
Thickening of palms and soles
9.
et keratoderma palmaris plantaris
10.
keratoderma palmoplantar
11.
keratosis palmaris et plantaris
12.
palmoplantar keratoderma
13.
palmoplantar keratodermas
Associated Drug(s)
NameNumber of ReportsReference(s)Data Source
1Hydroxyurea8763456CTD
Similar ADE(s)
NameSemantic Similarity
1Porokeratosis60%
2Epidermolysis Bullosa50%
3Dermatitis, Atopic48.3%
4Cutis Laxa44.9%
5Xeroderma Pigmentosum43.9%
6Ectodermal Dysplasia41.7%
7Aplasia Cutis Congenita41.7%
8Pyoderma Gangrenosum40%
9Ichthyosis, X-Linked39.5%
10Pseudoxanthoma Elasticum36.1%
11Xeroderma35.6%
12Sjogren-Larsson Syndrome35.6%
13Albinism35.5%
14Hyperkeratosis, Epidermolytic34.8%
15Cholesteatoma33.3%
16Parakeratosis33.3%
17Lupus Erythematosus, Cutaneous32.9%
18Panniculitis32.9%
19Systemic Scleroderma32.9%
20Morphea32.9%
21Porphyrias, Hepatic32.7%
22Acne Vulgaris32%
23Contact Dermatitis32%
24Eczema32%
25Erythema Multiforme32%
26Intertrigo32%
27Neurodermatitis32%
28Rhinophyma32%
29Perioral Dermatitis32%
30Acne32%
31Breast Diseases30.5%
32Dermatitis30.5%
33Exanthema30.5%
34Facial Dermatoses30.5%
35Hair Diseases30.5%
36Hand Dermatoses30.5%
37keratoacanthoma30.5%
38Nail Diseases30.5%
39Photosensitivity Disorders30.5%
40Prurigo30.5%
41Pyoderma30.5%
42Rosacea30.5%
43Sebaceous Gland Diseases30.5%
44Skin Diseases, Vesiculobullous30.5%
45Skin Ulcer30.5%
46Sweat Gland Diseases30.5%
47Skin Diseases, Papulosquamous30.5%
48Skin Diseases, Vascular30.5%
49Acneiform Eruptions30.5%
50Ocular Rosacea30.5%
51Subcorneal pustular dermatosis30.5%
52Erythematotelangiectatic Rosacea30.5%
53Papulopustular Rosacea30.5%
54Chronic Actinic Dermatitis30.5%
55Dermatitis, Phototoxic29.5%
56Pityriasis Lichenoides et Varioliformis Acuta29.5%
57Pityriasis Lichenoides29.5%
58Phototoxicity29.5%
59Acrodermatitis28.9%
60Gianotti-Crosti Syndrome28.9%
61Skin Abnormalities28.8%
62Foot Ulcer27.8%
63Actinic keratosis27%
64Dermatitis Herpetiformis27%
65Sebaceous Gland Neoplasms26.7%
66Panniculitis, Lupus Erythematosus26.4%
67Necrobiosis Lipoidica Diabeticorum25.6%
68Foot Diseases25.4%
69Dermatitis, Photoallergic25.2%
70Skin Diseases, Infectious24.7%
71Skin Neoplasms24.7%
72Pigmentation Disorders24.7%
73Behcet Syndrome24.4%
74Lipomatosis24.3%
75Pruritus24.3%
76Erythema24.3%
77Necrolytic Migratory Erythema24.3%
78Cutaneous Fistula24.3%
79Nephrogenic Fibrosing Dermopathy24.3%
80Nephrogenic Systemic Fibrosis24.3%
81Variegate Porphyria23.9%
82Acute intermittent porphyria23.9%
83Porphyria Cutanea Tarda23.9%
84Dermatitis, Irritant23.7%
85Acne Conglobata23.7%
86Erythema Induratum23.2%
87Dermatomyositis23%
88Urticaria Pigmentosa23%
89Nail-Patella Syndrome22.3%
90Lupus Erythematosus, Discoid21.3%
91Scleroderma, Limited21.3%
92Dermatitis, Occupational20.5%
93Mastocytosis20.1%
94Erythema Infectiosum20.1%
95Anhidrosis20%
96Pressure Ulcer20%
97Exanthema Subitum20%
98Folliculitis20%
99Foot Dermatoses20%
100Gynecomastia20%
101Hypertrichosis20%
102Hypohidrosis20%
103Hypotrichosis20%
104Leg Ulcer20%
105Miliaria20%
106Parapsoriasis20%
107Pityriasis20%
108Psoriasis20%
109Sweet Syndrome20%
110Hidradenitis20%
111Onycholysis20%
112Miliaria Rubra20%
113Hyperpigmentation20%
114Lichenoid Eruptions20%
115Chloracne20%
116Dermatitis, Allergic Contact19.8%
117Erythema Nodosum19.7%
118Toxic Epidermal Necrolysis19.6%
119Stevens-Johnson Syndrome19.6%
120Diaper Rash19.6%
121Tinea Capitis18.2%
122Onychomycosis18.2%
123Connective Tissue Diseases17.5%
124Ecthyma17.3%
125Granuloma Annulare16.6%
126Acantholysis16.2%
127Breast Cyst16.2%
128Pemphigoid, Benign Mucous Membrane16.2%
129Pemphigus16.2%
130Piedra16.2%
131Sunburn16.2%
132Argyria16%
133Hirsutism16%
134Lactation Disorder16%
135Mastitis16%
136Urticaria16%
137Adiposis Dolorosa15.9%
138Pruritus Vulvae15.9%
139Mastocytoma15.8%
140Pruritus Ani15.8%
141Angioedemas, Hereditary15.6%
142Keratosis15.3%
143Menkes Kinky Hair Syndrome15%
144Lichen Planus14.9%
145Melanosis14.9%
146Chloasma14.9%
147Pityriasis Rosea14.9%
148Pityriasis Rubra Pilaris14.9%
149Vitiligo14.9%
150Lichen Nitidus14.9%
151Hidradenitis Suppurativa14.8%
152Osteogenesis Imperfecta14.5%
153Erythema Chronicum Migrans13.7%
154Dermatomycoses13.5%
155Mucocutaneous Lymph Node Syndrome13.5%
156Skin Diseases, Bacterial13.5%
157Tinea Pedis13.4%
158Drug Eruptions13.3%
159Lipodystrophy13.3%
160Livedo Reticularis13.3%
161Malignant Atrophic Papulosis13.3%
162Keratoderma, Palmoplantar13.3%
163Polyarteritis Nodosa13.2%
164Takayasu Arteritis13.2%
165Neoplastic Syndromes, Hereditary12.7%
166Marfan Syndrome12.5%
167Aicardi's syndrome12.4%
168CHARGE Syndrome12.4%
169Acanthosis Nigricans12.3%
170Alopecia Areata12.3%
171Lentigo12.3%
172Fragile X Syndrome12.2%
173Multiple Epiphyseal Dysplasia12.2%
174Osteochondrodysplasias12.2%
175Pelger-Huet Anomaly12.2%
176Werner Syndrome12.2%
177Myasthenic Syndromes, Congenital12.2%
178Peutz-Jeghers Syndrome12.1%
179Alopecia12.1%
180Sweating, Gustatory12.1%
181Androgenetic Alopecia12.1%
182Auriculotemporal Syndrome12.1%
183Lice Infestations11.9%
184Varicose Ulcer11.9%
185Breast Neoplasms, Male11.9%
186Triple Negative Breast Neoplasms11.9%
187Cystic Fibrosis11.9%
188Galactorrhea11.8%
189Mycetoma11.8%
190Mucopolysaccharidosis II11.5%
191Anemia, Sickle Cell11.3%
192Thalassemia11.3%
193Muscular Dystrophy, Duchenne11.3%
194Beckwith-Wiedemann Syndrome11.1%
195Wolf-Hirschhorn Syndrome11.1%
196Dwarfism10.5%
197Cockayne Syndrome10.3%
198Collagen Diseases10.2%
199Mixed Connective Tissue Disease10.2%
200Mucinoses10.2%
201Larva Migrans10.1%
202Leishmaniasis10.1%
203Molluscum Contagiosum10.1%
204Muscular Dystrophy10.1%
205Lichen Planus, Oral10%
206Angioedema10%
207Familial Mediterranean Fever10%
208Onchocerciasis10%
209Chromoblastomycosis9.9%
210Dermatophytosis9.9%
211Sporotrichosis9.9%
212Tinea9.9%
213Tinea Versicolor9.9%
214Trichophytosis9.9%
215Hyalohyphomycosis9.9%
216Papillon-Lefevre Disease9.8%
217Acute Generalized Exanthematous Pustulosis9.8%
218Alstrom Syndrome9.8%
219Rett Syndrome9.8%
220Smith-Magenis syndrome9.6%
221Cri-du-Chat Syndrome9.5%
222Down Syndrome9.5%
223Trisomy 219.5%
224Homocystinuria9.3%
225Wiskott-Aldrich Syndrome8.8%
226Deformity8.8%
227Autoimmune Lymphoproliferative Syndrome8.7%
228CREST Syndrome8.7%
229Warts8.7%
230Kartagener Syndrome8.7%
231Holoprosencephaly8.6%
232Mucopolysaccharidosis III8.5%
233Candidiasis, Chronic Mucocutaneous8.5%
234Cutaneous Candidiasis8.5%
235Cartilage Diseases8.5%
236Erysipelas8.5%
237Rheumatism8.5%
238Serum Sickness8.5%
239Staphylococcal Skin Infections8.5%
240Chondromalacia8.5%
241Erythrasma8.4%
242Carcinoma, Lobular8.4%
243Arthritis, Psoriatic8.4%
244Sickle Cell Trait8.4%
245Prader-Willi Syndrome8.3%
246Leishmaniasis, Cutaneous8.2%
247Lupus Erythematosus, Systemic8.2%
248Overlap syndrome8.2%
249Eczema Herpeticum8.2%
250Fusariosis8.2%
251Amino Acid Metabolism, Inborn Errors8%
252Carbohydrate Metabolism, Inborn Errors8%
253Metal Metabolism, Inborn Errors8%
254Progeria8%
255Lysosomal Storage Diseases8%
256Smith-Lemli-Opitz Syndrome8%
257Cytochrome-c Oxidase Deficiency8%
258Peroxisomal Disorders8%
259Neuronal Ceroid-Lipofuscinoses8%
260Myotonic Dystrophy7.9%
261Giant Cell Arteritis7.9%
262Temporal Arteritis7.9%
263Rubinstein-Taybi Syndrome7.6%
264Primary Ciliary Dyskinesia7.5%
265Polycystic Kidney Diseases7.5%
266Williams Syndrome7.5%
267Kallmann Syndrome7.5%
268Tuberous Sclerosis7.5%
269Adrenoleukodystrophy7.4%
270Hereditary Angioedema Type III7.3%
271Hereditary Angioedema Types I and II7.3%
272Epidermodysplasia Verruciformis7.1%
273Herpes Labialis7.1%
274Hepatolenticular Degeneration7.1%
275Fetal Diseases7%
276Diabetic Foot7%
277Refsum Disease7%
278Staphylococcal Scalded Skin Syndrome7%
279Fabry Disease6.9%
280Amyloid Neuropathies, Familial6.9%
281Retinal Dysplasia6.8%
282Aniridia6.8%
283Retinitis Pigmentosa6.7%
284Pigmentary retinopathy6.7%
285Dupuytren Contracture6.7%
286Noonan Syndrome6.7%
287Scleromyxedema6.7%
288Acute Chest Syndrome6.6%
289Chronic granulomatous disease6.6%
290Blastomycosis6.6%
291Welander Distal Myopathy6.6%
292Glycogen storage disease type II6.6%
293HIV-Associated Lipodystrophy Syndrome6.5%
294Galactosemias6.5%
295Urea Cycle Disorders, Inborn6.5%
296Tyrosinemias6.5%
297carbuncle6.2%
298Condylomata Acuminata6.2%
299Furunculosis6.2%
300furuncle6.2%
301Impetigo6.1%
302Ataxia Telangiectasia6.1%
303Rhinoscleroma6.1%
304Alkaptonuria5.9%
305Glycogen Storage Disease5.9%
306Hypophosphatasia5.9%
307Propionic acidemia5.9%
308Dihydropyrimidine Dehydrogenase Deficiency5.9%
309Cystinosis5.9%
310Optic Atrophy, Hereditary, Leber5.9%
311Hyperphosphaturia5.9%
312Duane Retraction Syndrome5.8%
313Canavan Disease5.8%
314Alexander Disease5.8%
315Cellulitis5.7%
316Myotonia Congenita5.7%
317Thrombasthenia5.7%
318Antithrombin III Deficiency5.7%
319Protein C Deficiency5.7%
320Brain Diseases, Metabolic, Inborn5.7%
321Afibrinogenemia5.7%
322Dystonia Musculorum Deformans5.7%
323Factor VII Deficiency5.7%
324Factor X Deficiency5.7%
325Factor XII Deficiency5.7%
326Hemophilia A5.7%
327Activated Protein C Resistance5.7%
328Factor II deficiency5.7%
329Factor VIII Deficiency5.7%
330Factor V deficiency5.7%
331Factor XI Deficiency5.7%
332Hypoprothrombinemias5.7%
333Fanconi Anemia5.6%
334Lafora Disease5.6%
335Unverricht-Lundborg Syndrome5.6%
336Anemia, Diamond-Blackfan5.6%
337Polycystic Kidney, Autosomal Dominant5.6%
338Classical Lissencephalies and Subcortical Band Heterotopias5.6%
339Zellweger Syndrome5.6%
340Mesenteric Panniculitis5.4%
341Panniculitis, Peritoneal5.4%
342Tietze's Syndrome5.4%
343Orbital Cellulitis5.4%
344Myxoid cyst5.4%
345Gaucher Disease5.4%
346Leigh Disease5.4%
347Myxedema5.3%
348Meconium Aspiration Syndrome5.1%
349Multiple Endocrine Neoplasia5.1%
350Laryngomalacia5.1%
351Abdominal Cramps5.1%
352Abnormalities, Drug-Induced5.1%
353Amniotic Band Syndrome5.1%
354Asphyxia Neonatorum5.1%
355Infant, Premature, Diseases5.1%
356Situs Inversus5.1%
357Infantile Colic5.1%
358Pectus carinatum5.1%
359Congenital Hypothyroidism5%
360Tay-Sachs Disease4.9%
361Hypolipoproteinemias4.9%
362Charcot-Marie-Tooth Disease4.9%
363Antley-Bixler Syndrome Phenotype4.9%
364Hyperlipidemia, Familial Combined4.9%
365Glycogen Storage Disease Type I4.9%
366Glycogen Storage Disease Type V4.9%
367Hyperlipoproteinemia Type III4.9%
368Carbamoyl-Phosphate Synthase I Deficiency Disease4.9%
369Mobius Syndrome4.8%
370Niemann-Pick Disease, Type C4.7%
371Osteochondritis4.5%
372Polymyalgia Rheumatica4.5%
373Keloid4.4%
374Basal Cell Nevus Syndrome4.4%
375Familial Periodic Paralysis4.3%
376Bronchomalacia4.2%
377Tracheomalacia4.2%
378Eye Abnormalities4.2%
379Lactose Intolerance4.2%
380Cardiovascular Abnormalities4.2%
381Hyperhomocysteinemia4.2%
382Renal Aminoacidurias4.2%
383Fanconi Syndrome4.2%
384Pseudohypoaldosteronism4.2%
385Liddle Syndrome4.2%
386Hyperlipoproteinemia Type IV4.2%
387Hyperlipoproteinemia Type V4.2%
388Lymphatic Abnormalities4.1%
389Congenital Microtia4.1%
390Hypoalphalipoproteinemias4.1%
391Klinefelter Syndrome4.1%
392Anemia, Neonatal4.1%
393Persistent Fetal Circulation Syndrome4.1%
394Congenital diaphragmatic hernia4%
395Umbilical hernia4%
396Huntington Disease4%
397Rheumatoid Arthritis3.9%
398Juvenile arthritis3.9%
399Anencephaly3.9%
400Hydrops Fetalis3.8%
401Lupus Nephritis3.8%
402Gout3.7%
403Multiple Endocrine Neoplasia Type 13.7%
404Pseudohypoparathyroidism3.7%
405Friedreich Ataxia3.7%
406Renal tubular acidosis3.7%
407Turner Syndrome3.6%
408Nephroblastoma3.6%
409Urogenital Abnormalities3.5%
410Hypokalemic periodic paralysis3.5%
411Cystinuria3.5%
412Neonatal Abstinence Syndrome3.4%
413Fetal Growth Retardation3.4%
414Fetal Hypoxia3.4%
415Congenital nystagmus3.4%
416Fetal Alcohol Spectrum Disorders3.4%
417Maxillofacial Abnormalities3.3%
418Dural Arteriovenous Fistula3.3%
419Prune Belly Syndrome3.3%
420Twins, Conjoined3.3%
421Waardenburg Syndrome3.3%
422Toxoplasmosis, Congenital3.3%
423Dextrocardia3.3%
424Syphilis, Congenital3.3%
425Rheumatoid Nodule3.3%
426Adenomatous Polyposis Coli3.3%
427Familial Hypophosphatemic Rickets3.2%
428Arthritis, Gouty3.1%
429Glycosuria, Renal2.9%
430Congenital Hyperinsulinism2.9%
431Chorioamnionitis2.9%
432Felty Syndrome2.8%
433Anophthalmos2.7%
434Anus, Imperforate2.7%
435Hydranencephaly2.7%
436Microphthalmos2.7%
437Neural Tube Defects2.7%
438Paralysis, Obstetric2.7%
439Retinopathy of Prematurity2.7%
440Tethered Cord Syndrome2.7%
441Iniencephaly2.7%
442Craniorachischisis2.7%
443Limb Deformities, Congenital2.7%
444Exencephaly2.7%
445Septo-Optic Dysplasia2.7%
446Craniofacial Abnormalities2.7%
447Cortical Dysplasia2.7%
448Malformations of Cortical Development2.7%
449Anorectal Malformations2.7%
450Bloom Syndrome2.7%
451Bronchopulmonary Dysplasia2.6%
452Scimitar Syndrome2.6%
453Microcephaly2.6%
454Macrocephaly2.6%
455Abnormalities, Radiation-Induced2.5%
456Acrocephalosyndactylia2.5%
457Denys-Drash Syndrome2.5%
458Rheumatoid Vasculitis2.5%
459Craniosynostosis2.5%
460Syndactyly2.5%
461Brachycephaly2.5%
462MELAS Syndrome2.4%
463Porencephaly2.3%
464Blepharophimosis2.3%
465Laryngostenosis2.3%
466Mouth Abnormalities2.3%
467Respiratory Distress Syndrome, Newborn2.3%
468Esophageal Atresia2.2%
469Intestinal Atresia2.2%
470Horseshoe Kidney2.2%
471Pectus excavatum2.2%
472Klippel-Feil Syndrome2.2%
473Gastroschisis2.2%
474Synostosis2.2%
475Lymphangiectasis, Intestinal2.2%
476Sicca Syndrome2.2%
477Sjogren's Syndrome2.2%
478Ophthalmia Neonatorum2.2%
479Cleft Palate2.1%
480Jaw Abnormalities2%
481Poland Syndrome2%
482Amelia2%
483Arachnodactyly2%
484Ectopia Cordis2%
485Ectromelia2%
486Hemimelia2%
487Meningomyelocele2%
488Phocomelia2%
489Sirenomelia2%
490Spina Bifida2%
491Polydactyly2%
492Brachydactyly2%
493Plagiocephaly2%
494Lower Extremity Deformities, Congenital2%
495Upper Extremity Deformities, Congenital2%
496Single umbilical artery2%
497Arthrogryposis2%
498Choanal Atresia2%
499Tracheobronchomegaly2%
500Laryngocele2%
501Choledochal Cyst1.9%
502Hermaphroditism1.9%
503Disorders of Sex Development1.9%
504Cryptorchidism1.9%
505Hypospadias1.9%
506Central Nervous System Cysts1.9%
507Dandy-Walker Syndrome1.9%
508Leukomalacia, Periventricular1.9%
509POEMS Syndrome1.9%
510Nesidioblastosis1.9%
511Lupus Vasculitis, Central Nervous System1.9%
512Micrognathism1.7%
513Pierre Robin Syndrome1.7%
514Bladder Exstrophy1.7%
515Epispadias1.7%
516Multicystic Dysplastic Kidney1.7%
517Aortic coarctation1.7%
518Cor Triatriatum1.7%
519Coronary Vessel Anomalies1.7%
520Dental Enamel Hypoplasia1.7%
521Patent ductus arteriosus1.7%
522Ebstein Anomaly1.7%
523Heart Septal Defects1.7%
524Hyaline Membrane Disease1.7%
525Hypodontia1.7%
526Macrostomia1.7%
527Meningocele1.7%
528Microstomia1.7%
529Tetralogy of Fallot1.7%
530Transposition of Great Vessels1.7%
531Hypoplastic Left Heart Syndrome1.7%
532May-Thurner Syndrome1.7%
533Encephalocele1.7%
534Craniofacial Dysostosis1.6%
535Dermal Sinus1.6%
536Spina Bifida Cystica1.6%
537Wolff-Parkinson-White Syndrome1.6%
538Spina Bifida Occulta1.6%
539Lissencephaly1.6%
540Polymicrogyria1.6%
541Pachygyria1.6%
542Schizencephaly1.6%
543Periventricular Nodular Heterotopia1.6%
544Retrognathia1.6%
545Kernicterus1.5%
546Hyperandrogenism1.5%
547Long QT Syndrome1.4%
548Platybasia1.4%
549Tricuspid Atresia1.4%
550Arrhythmogenic Right Ventricular Dysplasia1.4%
551Gonadal Dysgenesis1.4%
552Adrenogenital Syndrome1.4%
553Ovotesticular Disorders of Sex Development1.4%
554Prognathism1.4%
555Aortopulmonary Septal Defect1.4%
556Double Outlet Right Ventricle1.4%
557Endocardial Cushion Defects1.4%
558Myocardial bridging1.4%
559Aorticopulmonary Septal Defect1.4%
560Truncus Arteriosus, Persistent1.2%
561Goldenhar Syndrome1.2%
562Mandibulofacial Dysostosis1.2%
563Romano-Ward Syndrome1.2%
564Talipes1.1%
565Congenital clubfoot1%
566Vertical Talus1%
567Arteriovenous fistula0.9%
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