MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperlipoproteinemia Type V

(UMLS:C0020481)

Definition:: A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I .
UMLS ID:: C0020481
MeSH ID:: D006954

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.398.493

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.500.500.644.495|C18.452.584.500.500.851.750|C18.452.648.398.493

Synonym(s)

Hyperlipoproteinemia Type V

Familial type 5 hyperlipoproteinaemia

Familial type 5 hyperlipoproteinemia

Familial type V hyperlipoproteinaemia

Familial type V hyperlipoproteinemia

Frederickson type V hyperlipidemia

Fredrickson Type V Lipidemia

Fredrickson type V hyperlipoproteinaemia

Fredrickson type V hyperlipoproteinemia

10.

Fredrickson; type V hyperlipoproteinemia

11.

HYPERLIPEMIA, MIXED

12.

HYPERLIPOPROTEINEMIA, TYPE V

13.

HYPERPREBETALIPOPROTEINEMIA WITH CHYLOMICRONEMIA

14.

Hyperlipoproteinemia, Frederickson type V

15.

Mixed hyperlipemia

16.

Type V Lipidemia

17.

Type V hyperlipidaemia

18.

hyperlipoproteinemia type V

19.

hyperlipoproteinemia; Fredrickson type V

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Bezafibrate		906593	CTD
2	Niacin		906593	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperlipoproteinemia Type IV	67.3%
2	Hyperlipidemia, Familial Combined	54.1%
3	Hyperlipoproteinemia Type III	53.9%
4	Hypolipoproteinemias	50.8%
5	Smith-Lemli-Opitz Syndrome	48.1%
6	Hypoalphalipoproteinemias	34.8%
7	Hypercholesterolemia	32.5%
8	Brain Diseases, Metabolic, Inborn	31.6%
9	Amino Acid Metabolism, Inborn Errors	29.9%
10	Carbohydrate Metabolism, Inborn Errors	29.9%
11	Metal Metabolism, Inborn Errors	29.9%
12	Progeria	29.9%
13	Lysosomal Storage Diseases	29.9%
14	Peroxisomal Disorders	29.9%
15	Wasting Syndrome	29.8%
16	Neuronal Ceroid-Lipofuscinoses	29.3%
17	Lipodystrophy	29.2%
18	Pseudohypoparathyroidism	29%
19	Leigh Disease	28.3%
20	Galactosemias	27.1%
21	Urea Cycle Disorders, Inborn	27.1%
22	Tyrosinemias	27.1%
23	Acid-Base Imbalance	26.4%
24	Calcium Metabolism Disorders	26.4%
25	Iron Metabolism Disorders	26.4%
26	Phosphorus Metabolism Disorders	26.4%
27	Water-Electrolyte Imbalance	26.4%
28	Mitochondrial Diseases	26.4%
29	Glucose Metabolism Disorders	26.4%
30	Xanthomatosis	26%
31	Xanthoma	26%
32	Gaucher Disease	25.1%
33	Hyperphosphaturia	24.6%
34	Hypercalcemia	24.3%
35	Hypocalcemia	24.3%
36	Milk-Alkali Syndrome	24.3%
37	Hyperhomocysteinemia	24.2%
38	Carbamoyl-Phosphate Synthase I Deficiency Disease	23.9%
39	Cytochrome-c Oxidase Deficiency	23.5%
40	Lactose Intolerance	23.3%
41	Glycogen storage disease type II	22.6%
42	Osteopenia	22.3%
43	Fabry Disease	22.3%
44	Menkes Kinky Hair Syndrome	22.2%
45	Brain Diseases, Metabolic	22.1%
46	Lipomatosis	22.1%
47	Homocystinuria	21.8%
48	Sjogren-Larsson Syndrome	21.6%
49	Adrenoleukodystrophy	21%
50	Werner Syndrome	20.4%
51	Zellweger Syndrome	20.3%
52	Hepatolenticular Degeneration	20.3%
53	Niemann-Pick Disease, Type C	19.9%
54	Refsum Disease	19.8%
55	Tay-Sachs Disease	19.6%
56	Rickets	19.1%
57	Alkaptonuria	18.9%
58	Glycogen Storage Disease	18.9%
59	Hypophosphatasia	18.9%
60	Propionic acidemia	18.9%
61	Dihydropyrimidine Dehydrogenase Deficiency	18.9%
62	Cystinosis	18.9%
63	Hyperlipoproteinemia Type V	18.3%
64	Amyloid Neuropathies, Familial	18.3%
65	Mucopolysaccharidosis III	18.1%
66	Hyperlipoproteinemias	17.7%
67	Hypertriglyceridemia	17.7%
68	Familial Hypophosphatemic Rickets	17.6%
69	Renal tubular acidosis	17.4%
70	Nutrition Disorders	17.1%
71	Mucopolysaccharidosis II	16.8%
72	Albinism	15.9%
73	Ichthyosis, X-Linked	14.6%
74	Acidosis	14.5%
75	Alkalosis	14.5%
76	Amyloidosis	14.5%
77	Calcinosis	14.5%
78	Hyperglycemia	14.5%
79	Hyperinsulinism	14.5%
80	Hyperkalemia	14.5%
81	Hypernatremia	14.5%
82	Hypoglycemia	14.5%
83	Hypokalemia	14.5%
84	Hyponatremia	14.5%
85	Hypophosphatemia	14.5%
86	Metabolic acidosis	14.5%
87	Iron Overload	14.5%
88	Familial Periodic Paralysis	14.5%
89	MELAS Syndrome	14.3%
90	Glycosuria, Renal	14.3%
91	Renal Aminoacidurias	14.2%
92	Fanconi Syndrome	14.2%
93	Pseudohypoaldosteronism	14.2%
94	Liddle Syndrome	14.2%
95	Cockayne Syndrome	14.2%
96	Bloom Syndrome	13.7%
97	Glycogen Storage Disease Type I	13.5%
98	Glycogen Storage Disease Type V	13.5%
99	Antley-Bixler Syndrome Phenotype	13.4%
100	Congenital Hyperinsulinism	13.1%
101	Porphyrias, Hepatic	12.9%
102	Mitochondrial Encephalomyopathies	12.9%
103	Gout	12.9%
104	Fanconi Anemia	12.7%
105	Adiposis Dolorosa	12.6%
106	Diabetes Mellitus	12.5%
107	Dehydration	12.3%
108	Water Intoxication	12.3%
109	Achlorhydria	12.1%
110	Osteoporosis	12.1%
111	Bone Demineralization, Pathologic	12.1%
112	Post-Traumatic Osteoporosis	12.1%
113	Celiac Disease	12.1%
114	Sprue, Tropical	12.1%
115	Steatorrhea	12.1%
116	Sprue	12.1%
117	HIV-Associated Lipodystrophy Syndrome	11.9%
118	Canavan Disease	11.7%
119	Alexander Disease	11.7%
120	Osteomalacia	11.5%
121	Ataxia Telangiectasia	11.3%
122	HIV Wasting Syndrome	10.8%
123	Mitochondrial Myopathies	10.5%
124	Myelinolysis, Central Pontine	10.5%
125	Glycosuria	10.4%
126	Reye Syndrome	10.4%
127	Hepatic Encephalopathy	10.3%
128	Diabetic Ketoacidosis	10.3%
129	Hypokalemic periodic paralysis	10.2%
130	Friedreich Ataxia	10.2%
131	Cystinuria	10.1%
132	Optic Atrophy, Hereditary, Leber	10.1%
133	Lipid Metabolism Disorders	9.8%
134	Xeroderma Pigmentosum	9.5%
135	Necrobiosis Lipoidica Diabeticorum	9.1%
136	Arthritis, Gouty	9.1%
137	Child Nutrition Disorders	8.8%
138	Hypervitaminosis A	8.8%
139	Infant Nutrition Disorders	8.8%
140	Malnutrition	8.8%
141	Wernicke Encephalopathy	8.8%
142	Acidosis, Lactic	8.6%
143	Calciphylaxis	8.6%
144	Hemosiderosis	8.6%
145	Ketosis	8.6%
146	Ketonuria	8.6%
147	Ketoacidosis	8.6%
148	Ketonemia	8.6%
149	Vascular calcification	8.6%
150	Neoplastic Syndromes, Hereditary	8.5%
151	Nesidioblastosis	8.5%
152	Renal Osteodystrophy	8.4%
153	Renal rickets	8.4%
154	CHARGE Syndrome	8.4%
155	Cystic Fibrosis	8.4%
156	Kernicterus	8.4%
157	Aicardi's syndrome	8.3%
158	Multiple Epiphyseal Dysplasia	8.2%
159	Osteochondrodysplasias	8.2%
160	Pelger-Huet Anomaly	8.2%
161	Myasthenic Syndromes, Congenital	8.2%
162	Variegate Porphyria	7.8%
163	Acute intermittent porphyria	7.8%
164	Porphyria Cutanea Tarda	7.8%
165	Nail-Patella Syndrome	7.5%
166	Anemia, Sickle Cell	7.3%
167	Thalassemia	7.3%
168	Muscular Dystrophy, Duchenne	7.3%
169	Acidosis, Respiratory	7.2%
170	Alkalosis, Respiratory	7.2%
171	Dwarfism	7.2%
172	Kearns-Sayre syndrome	7.2%
173	Insulin Resistance	7.2%
174	Osteoporosis, Postmenopausal	7.2%
175	Fragile X Syndrome	7.1%
176	Prader-Willi Syndrome	7%
177	Muscular Dystrophy	7%
178	Osteogenesis Imperfecta	7%
179	Beckwith-Wiedemann Syndrome	7%
180	Wolf-Hirschhorn Syndrome	7%
181	Gestational Diabetes	6.4%
182	Latent Autoimmune Diabetes in Adults	6.4%
183	Diabetes Mellitus, Experimental	6.3%
184	Alstrom Syndrome	6.2%
185	Autoimmune Lymphoproliferative Syndrome	6.2%
186	Nephrocalcinosis	6.2%
187	Tetany	6.2%
188	Smith-Magenis syndrome	6.2%
189	Cerebral Amyloid Angiopathy	6.1%
190	Cri-du-Chat Syndrome	6.1%
191	Down Syndrome	6.1%
192	Angioedemas, Hereditary	6.1%
193	Trisomy 21	6.1%
194	Deformity	6%
195	Marfan Syndrome	6%
196	Kartagener Syndrome	6%
197	Wiskott-Aldrich Syndrome	5.8%
198	Familial Mediterranean Fever	5.8%
199	Dyslipidemias	5.8%
200	Holoprosencephaly	5.6%
201	Rett Syndrome	5.5%
202	Primary amyloidosis	5.5%
203	Ectodermal Dysplasia	5.4%
204	Aplasia Cutis Congenita	5.4%
205	Kallmann Syndrome	5.3%
206	Myotonic Dystrophy	5.3%
207	Fetal Diseases	5.1%
208	Rubinstein-Taybi Syndrome	5%
209	Tuberous Sclerosis	5%
210	Amyotrophic Lateral Sclerosis	4.9%
211	Polycystic Kidney Diseases	4.8%
212	Williams Syndrome	4.8%
213	Deficiency Diseases	4.8%
214	Starvation	4.8%
215	Refeeding Syndrome	4.8%
216	Sickle Cell Trait	4.8%
217	Primary Ciliary Dyskinesia	4.7%
218	Retinal Dysplasia	4.5%
219	Aniridia	4.4%
220	Epidermolysis Bullosa	4.4%
221	CREST Syndrome	4.3%
222	Cutis Laxa	4.2%
223	Retinitis Pigmentosa	4.2%
224	Pigmentary retinopathy	4.2%
225	Porokeratosis	4.2%
226	Keratoderma, Palmoplantar	4.2%
227	Chronic granulomatous disease	4.2%
228	Welander Distal Myopathy	4.1%
229	Acute Chest Syndrome	3.9%
230	Duane Retraction Syndrome	3.7%
231	Meconium Aspiration Syndrome	3.7%
232	Peutz-Jeghers Syndrome	3.7%
233	Myotonia Congenita	3.7%
234	Thrombasthenia	3.7%
235	Antithrombin III Deficiency	3.7%
236	Protein C Deficiency	3.7%
237	Afibrinogenemia	3.6%
238	Dystonia Musculorum Deformans	3.6%
239	Factor VII Deficiency	3.6%
240	Factor X Deficiency	3.6%
241	Factor XII Deficiency	3.6%
242	Hemophilia A	3.6%
243	Activated Protein C Resistance	3.6%
244	Factor II deficiency	3.6%
245	Factor VIII Deficiency	3.6%
246	Factor V deficiency	3.6%
247	Factor XI Deficiency	3.6%
248	Hypoprothrombinemias	3.6%
249	Lafora Disease	3.6%
250	Unverricht-Lundborg Syndrome	3.6%
251	Anemia, Diamond-Blackfan	3.6%
252	Frontotemporal dementia	3.6%
253	Pseudoxanthoma Elasticum	3.6%
254	Multiple Endocrine Neoplasia	3.3%
255	Xeroderma	3.3%
256	Mobius Syndrome	3.3%
257	Congenital Hypothyroidism	3.3%
258	Dermatitis, Atopic	3.3%
259	Abdominal Cramps	3.3%
260	Abnormalities, Drug-Induced	3.3%
261	Amniotic Band Syndrome	3.3%
262	Asphyxia Neonatorum	3.3%
263	Infant, Premature, Diseases	3.3%
264	Situs Inversus	3.3%
265	Infantile Colic	3.3%
266	Polycystic Kidney, Autosomal Dominant	3.2%
267	Classical Lissencephalies and Subcortical Band Heterotopias	3.1%
268	Hyperkeratosis, Epidermolytic	3%
269	Basal Cell Nevus Syndrome	3%
270	Obesity	3%
271	Behcet Syndrome	2.9%
272	Kwashiorkor	2.9%
273	Magnesium Deficiency	2.9%
274	Potassium Deficiency	2.9%
275	Protein Deficiency	2.9%
276	Avitaminosis	2.9%
277	Charcot-Marie-Tooth Disease	2.9%
278	Eye Abnormalities	2.8%
279	Cardiovascular Abnormalities	2.8%
280	Skin Abnormalities	2.8%
281	Lymphatic Abnormalities	2.8%
282	Congenital Microtia	2.8%
283	Papillon-Lefevre Disease	2.7%
284	Anemia, Neonatal	2.7%
285	Persistent Fetal Circulation Syndrome	2.7%
286	Congenital diaphragmatic hernia	2.7%
287	Umbilical hernia	2.7%
288	Huntington Disease	2.7%
289	Urogenital Abnormalities	2.4%
290	Nephroblastoma	2.4%
291	Neonatal Abstinence Syndrome	2.4%
292	Fetal Growth Retardation	2.3%
293	Fetal Hypoxia	2.3%
294	Congenital nystagmus	2.3%
295	Fetal Alcohol Spectrum Disorders	2.3%
296	Toxoplasmosis, Congenital	2.3%
297	Anencephaly	2.3%
298	Syphilis, Congenital	2.3%
299	Adenomatous Polyposis Coli	2.2%
300	Hydrops Fetalis	2.2%
301	Klinefelter Syndrome	2.2%
302	Multiple Endocrine Neoplasia Type 1	2.2%
303	Turner Syndrome	2.1%
304	Chorioamnionitis	2%
305	Maxillofacial Abnormalities	2%
306	Dural Arteriovenous Fistula	2%
307	Obesity, Abdominal	2%
308	Dextrocardia	2%
309	Prune Belly Syndrome	1.9%
310	Twins, Conjoined	1.9%
311	Waardenburg Syndrome	1.9%
312	Ascorbic Acid Deficiency	1.9%
313	Vitamin A Deficiency	1.9%
314	Vitamin D Deficiency	1.9%
315	Vitamin E Deficiency	1.9%
316	Marasmus	1.9%
317	Abnormalities, Radiation-Induced	1.8%
318	Pediatric Obesity	1.8%
319	Scimitar Syndrome	1.7%
320	Anophthalmos	1.6%
321	Anus, Imperforate	1.6%
322	Hydranencephaly	1.6%
323	Microphthalmos	1.6%
324	Neural Tube Defects	1.6%
325	Paralysis, Obstetric	1.6%
326	Retinopathy of Prematurity	1.6%
327	Tethered Cord Syndrome	1.6%
328	Iniencephaly	1.6%
329	Craniorachischisis	1.6%
330	Limb Deformities, Congenital	1.6%
331	Exencephaly	1.6%
332	Septo-Optic Dysplasia	1.6%
333	Craniofacial Abnormalities	1.6%
334	Cortical Dysplasia	1.6%
335	Malformations of Cortical Development	1.6%
336	Anorectal Malformations	1.6%
337	Ophthalmia Neonatorum	1.6%
338	Bronchopulmonary Dysplasia	1.6%
339	Denys-Drash Syndrome	1.5%
340	Craniosynostosis	1.4%
341	Syndactyly	1.4%
342	Brachycephaly	1.4%
343	Folic Acid Deficiency	1.4%
344	Pellagra	1.4%
345	Thiamine Deficiency	1.4%
346	Vitamin B 12 Deficiency	1.4%
347	Vitamin B 6 Deficiency	1.4%
348	Pyridoxine Deficiency	1.4%
349	Blepharophimosis	1.4%
350	Laryngostenosis	1.4%
351	Mouth Abnormalities	1.4%
352	Respiratory Distress Syndrome, Newborn	1.4%
353	Microcephaly	1.4%
354	Macrocephaly	1.4%
355	Esophageal Atresia	1.4%
356	Intestinal Atresia	1.4%
357	Horseshoe Kidney	1.4%
358	Pectus excavatum	1.4%
359	Klippel-Feil Syndrome	1.4%
360	Gastroschisis	1.4%
361	Synostosis	1.4%
362	Acrodermatitis	1.4%
363	Lymphangiectasis, Intestinal	1.4%
364	Gianotti-Crosti Syndrome	1.4%
365	Vitamin K Deficiency	1.4%
366	Acrocephalosyndactylia	1.4%
367	Noonan Syndrome	1.3%
368	Arthrogryposis	1.3%
369	Choanal Atresia	1.3%
370	Tracheobronchomegaly	1.3%
371	Laryngocele	1.3%
372	Choledochal Cyst	1.2%
373	Hermaphroditism	1.2%
374	Disorders of Sex Development	1.2%
375	Cryptorchidism	1.2%
376	Hypospadias	1.2%
377	Central Nervous System Cysts	1.2%
378	Dandy-Walker Syndrome	1.2%
379	Leukomalacia, Periventricular	1.2%
380	POEMS Syndrome	1.2%
381	Porencephaly	1.2%
382	Beriberi	1.2%
383	Cleft Palate	1.2%
384	Jaw Abnormalities	1.1%
385	Laryngomalacia	1.1%
386	Pectus carinatum	1.1%
387	Bladder Exstrophy	1.1%
388	Epispadias	1.1%
389	Multicystic Dysplastic Kidney	1.1%
390	Amelia	1.1%
391	Arachnodactyly	1.1%
392	Ectopia Cordis	1.1%
393	Ectromelia	1.1%
394	Hemimelia	1.1%
395	Meningomyelocele	1.1%
396	Phocomelia	1.1%
397	Sirenomelia	1.1%
398	Spina Bifida	1.1%
399	Polydactyly	1.1%
400	Brachydactyly	1.1%
401	Plagiocephaly	1.1%
402	Lower Extremity Deformities, Congenital	1.1%
403	Upper Extremity Deformities, Congenital	1.1%
404	Single umbilical artery	1.1%
405	Poland Syndrome	1.1%
406	Scurvy	1%
407	Anemia, Pernicious	1%
408	Aortic coarctation	0.9%
409	Cor Triatriatum	0.9%
410	Coronary Vessel Anomalies	0.9%
411	Dental Enamel Hypoplasia	0.9%
412	Patent ductus arteriosus	0.9%
413	Ebstein Anomaly	0.9%
414	Heart Septal Defects	0.9%
415	Hyaline Membrane Disease	0.9%
416	Hypodontia	0.9%
417	Macrostomia	0.9%
418	Meningocele	0.9%
419	Microstomia	0.9%
420	Tetralogy of Fallot	0.9%
421	Transposition of Great Vessels	0.9%
422	Hypoplastic Left Heart Syndrome	0.9%
423	May-Thurner Syndrome	0.9%
424	Encephalocele	0.9%
425	Craniofacial Dysostosis	0.9%
426	Wolff-Parkinson-White Syndrome	0.9%
427	Micrognathism	0.9%
428	Pierre Robin Syndrome	0.9%
429	Long QT Syndrome	0.8%
430	Platybasia	0.8%
431	Tricuspid Atresia	0.8%
432	Arrhythmogenic Right Ventricular Dysplasia	0.8%
433	Gonadal Dysgenesis	0.8%
434	Bronchomalacia	0.8%
435	Adrenogenital Syndrome	0.8%
436	Tracheomalacia	0.8%
437	Ovotesticular Disorders of Sex Development	0.8%
438	Retrognathia	0.8%
439	Hyperandrogenism	0.8%
440	Dermal Sinus	0.8%
441	Spina Bifida Cystica	0.8%
442	Spina Bifida Occulta	0.8%
443	Lissencephaly	0.8%
444	Polymicrogyria	0.8%
445	Pachygyria	0.8%
446	Schizencephaly	0.8%
447	Periventricular Nodular Heterotopia	0.8%
448	Prognathism	0.7%
449	Subacute Combined Degeneration	0.7%
450	Aortopulmonary Septal Defect	0.7%
451	Double Outlet Right Ventricle	0.7%
452	Endocardial Cushion Defects	0.7%
453	Myocardial bridging	0.7%
454	Aorticopulmonary Septal Defect	0.7%
455	Mandibulofacial Dysostosis	0.6%
456	Romano-Ward Syndrome	0.6%
457	Truncus Arteriosus, Persistent	0.6%
458	Goldenhar Syndrome	0.6%
459	Talipes	0.5%
460	Arteriovenous fistula	0.5%
461	Congenital clubfoot	0.4%
462	Vertical Talus	0.4%

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