MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Synostosis

(UMLS:C0391889)

UMLS ID:: C0391889
MeSH ID:: D013580

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.370.894|C05.660.906

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.906

Synonym(s)

Synostosis

Bony union

Junctura ossea

Synostosis, NOS

bony union

synostosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 6	US FAERS
2	Aripiprazole	FAERS: 4	OFFSIDES US FAERS
3	Metronidazole	FAERS: 4	US FAERS
4	Methotrexate	FAERS: 3	US FAERS
5	Ondansetron	FAERS: 3	US FAERS
6	Valproic Acid	FAERS: 3	US FAERS
7	reviparin	FAERS: 3	US FAERS
8	Fluconazole	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
9	Valproic Acid	FAERS: 2	US FAERS
10	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1	US FAERS
11	Amlodipine	FAERS: 1	US FAERS
12	Carbamazepine	FAERS: 1	US FAERS
13	Citalopram	FAERS: 1	US FAERS
14	Fluoxetine	FAERS: 1	US FAERS
15	Nitrofurantoin	FAERS: 1	US FAERS
16	Dapsone		OFFSIDES
17	Nevirapine		OFFSIDES
18	Pentamidine		OFFSIDES
19	Pentamidine		OFFSIDES
20	dicyclomine, doxylamine, pyridoxine drug combination	Canada Vigilance: 1	Canada Vigilance
21	efavirenz		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Klippel-Feil Syndrome	51.7%
2	Pectus excavatum	47.5%
3	Craniofacial Dysostosis	42.5%
4	Pectus carinatum	41.3%
5	Arthrogryposis	40.9%
6	Platybasia	40%
7	Limb Deformities, Congenital	38.8%
8	Craniofacial Abnormalities	38.8%
9	Rubinstein-Taybi Syndrome	34.8%
10	Gastroschisis	32%
11	Goldenhar Syndrome	29.2%
12	Mandibulofacial Dysostosis	28.9%
13	Amelia	28%
14	Arachnodactyly	28%
15	Ectromelia	28%
16	Hemimelia	28%
17	Phocomelia	28%
18	Sirenomelia	28%
19	Polydactyly	28%
20	Brachydactyly	28%
21	Plagiocephaly	28%
22	Lower Extremity Deformities, Congenital	28%
23	Upper Extremity Deformities, Congenital	28%
24	Holoprosencephaly	26.2%
25	Maxillofacial Abnormalities	26%
26	Osteoarthropathy, Secondary Hypertrophic	24.8%
27	Gigantism	23.5%
28	Microcephaly	23.3%
29	Macrocephaly	23.3%
30	Talipes	23%
31	Multiple Epiphyseal Dysplasia	22.4%
32	Osteochondrodysplasias	22.4%
33	Jaw Abnormalities	21%
34	Osteochondritis	20.6%
35	Craniosynostosis	20.4%
36	Syndactyly	20.4%
37	Brachycephaly	20.4%
38	Acrocephalosyndactylia	20.2%
39	Congenital clubfoot	20%
40	Vertical Talus	20%
41	Hyperostosis	19.7%
42	Osteitis	19.7%
43	Osteitis Deformans	19.7%
44	Osteochondrosis	19.7%
45	Spinal Diseases	19.7%
46	Porencephaly	19.6%
47	Dwarfism	19.3%
48	Noonan Syndrome	19%
49	Fasciitis	18.6%
50	Foot Deformities	18.6%
51	Arthropathy	18.6%
52	Marfan Syndrome	18.2%
53	Contracture	17.9%
54	Fasciitis, Plantar	17.9%
55	Laryngomalacia	17.6%
56	Micrognathism	17.2%
57	Pierre Robin Syndrome	17.2%
58	Prognathism	16.8%
59	Spinal Neoplasms	16.8%
60	Spondylitis	16.8%
61	Poland Syndrome	16.6%
62	Bone Diseases, Endocrine	16.3%
63	Congenital Hypothyroidism	16%
64	Bone Diseases, Infectious	15.9%
65	Bone neoplasms	15.9%
66	Osteopenia	15.9%
67	Chondrodysplasia Punctata	15.8%
68	Enchondromatosis	15.8%
69	Osteosclerosis	15.8%
70	Kashin-Beck Disease	15.8%
71	Bone Resorption	15.6%
72	Aseptic Necrosis of Bone	15.6%
73	Beckwith-Wiedemann Syndrome	15.6%
74	Wolf-Hirschhorn Syndrome	15.6%
75	Retrognathia	15.5%
76	Abnormalities, Drug-Induced	15.4%
77	Situs Inversus	15.4%
78	Cleft Palate	15.4%
79	Jaw Diseases	15.3%
80	Nail-Patella Syndrome	15.1%
81	Osteoarthritis, Spine	15.1%
82	Cartilage Diseases	14.9%
83	Foot Diseases	14.9%
84	Myopathy	14.9%
85	Rheumatism	14.9%
86	Chondromalacia	14.9%
87	Fibromyalgia	14.9%
88	Polymyalgia Rheumatica	14.9%
89	Metatarsalgia	14.8%
90	Cockayne Syndrome	14.4%
91	Gout	14.2%
92	Bronchomalacia	14.2%
93	Tracheomalacia	14.2%
94	Osteogenesis Imperfecta	14%
95	Basal Cell Nevus Syndrome	13.8%
96	Smith-Magenis syndrome	13.5%
97	Cri-du-Chat Syndrome	13.3%
98	Down Syndrome	13.3%
99	Trisomy 21	13.3%
100	Aicardi's syndrome	13.2%
101	Ischemic contracture	12.9%
102	Eye Abnormalities	12.8%
103	Cardiovascular Abnormalities	12.8%
104	Ankylosing spondylitis	12.6%
105	Ainhum	12.6%
106	Spinal Stenosis	12.6%
107	Spondylosis	12.6%
108	Intervertebral Disc Degeneration	12.6%
109	Melorheostosis	12.4%
110	Osteopetrosis	12.4%
111	Temporomandibular Joint Disorders	12.4%
112	Skin Abnormalities	12.4%
113	Lymphatic Abnormalities	12.4%
114	Congenital Microtia	12.4%
115	Rheumatic Fever	12.4%
116	Congenital diaphragmatic hernia	12.2%
117	Discitis	12.1%
118	Hip Contracture	12.1%
119	Periarthritis	12.1%
120	Ectodermal Dysplasia	11.7%
121	Aplasia Cutis Congenita	11.7%
122	Anencephaly	11.7%
123	Prader-Willi Syndrome	11.6%
124	Temporomandibular Joint Dysfunction Syndrome	11.4%
125	Arthritis	11.1%
126	Bursitis	11.1%
127	Joint Instability	11.1%
128	Myofascial Pain Syndromes	11.1%
129	Rhabdomyolysis	11.1%
130	Synovitis	11.1%
131	Joint laxity	11.1%
132	Polyarthritis	11.1%
133	Frozen shoulder	11.1%
134	Patellofemoral Pain Syndrome	11.1%
135	Arthritis, Psoriatic	10.8%
136	Rheumatoid Arthritis	10.7%
137	Juvenile arthritis	10.7%
138	Osteoarthritis, Knee	10.7%
139	Urogenital Abnormalities	10.7%
140	Bone Diseases	10.6%
141	Spondylarthropathies	10.6%
142	Arthritis, Gouty	10.5%
143	Tuberculosis, Spinal	10.3%
144	CHARGE Syndrome	10.2%
145	Dural Arteriovenous Fistula	10.1%
146	Prune Belly Syndrome	10.1%
147	Twins, Conjoined	10.1%
148	Waardenburg Syndrome	10.1%
149	Osteomyelitis	10.1%
150	Osteoporosis	10.1%
151	Periostitis	10.1%
152	Bone Demineralization, Pathologic	10.1%
153	Post-Traumatic Osteoporosis	10.1%
154	Kartagener Syndrome	10%
155	Alveolar Bone Loss	10%
156	Dextrocardia	10%
157	Femur Head Necrosis	10%
158	Osteolysis	10%
159	Arthritis, Reactive	9.8%
160	Eosinophilic Granuloma	9.6%
161	Lordosis	9.2%
162	Spondylolysis	9.2%
163	kyphosis	9.2%
164	Compartment syndromes	9%
165	Maxillary Diseases	9%
166	Tendinitis	9%
167	Tendinopathy	9%
168	Genetic Diseases, Inborn	8.8%
169	Hemarthrosis	8.8%
170	Myositis	8.8%
171	Tietze's Syndrome	8.8%
172	Isaacs syndrome	8.8%
173	Myotonic Disorders	8.8%
174	Rheumatoid Nodule	8.8%
175	Xeroderma	8.7%
176	Mobius Syndrome	8.7%
177	Muscular Dystrophy	8.4%
178	Acromegaly	8.3%
179	Joint Tuberculosis	8.3%
180	Tuberculosis, Osteoarticular	8.3%
181	Bone Tuberculosis	8.3%
182	Anophthalmos	8.2%
183	Anus, Imperforate	8.2%
184	Hydranencephaly	8.2%
185	Microphthalmos	8.2%
186	Neural Tube Defects	8.2%
187	Tethered Cord Syndrome	8.2%
188	Iniencephaly	8.2%
189	Craniorachischisis	8.2%
190	Exencephaly	8.2%
191	Septo-Optic Dysplasia	8.2%
192	Cortical Dysplasia	8.2%
193	Malformations of Cortical Development	8.2%
194	Anorectal Malformations	8.2%
195	Bloom Syndrome	8.1%
196	Scimitar Syndrome	8%
197	Myotonic Dystrophy	7.9%
198	Alstrom Syndrome	7.7%
199	Familial Periodic Paralysis	7.7%
200	Felty Syndrome	7.6%
201	Polycystic Kidney Diseases	7.6%
202	Williams Syndrome	7.6%
203	Bunion	7.6%
204	Fibrodysplasia Ossificans Progressiva	7.6%
205	Myoglobinuria	7.6%
206	Myositis Ossificans	7.6%
207	Tenosynovitis	7.6%
208	Sacroiliitis	7.6%
209	Abnormalities, Radiation-Induced	7.5%
210	Pseudohypoparathyroidism	7.5%
211	Spondylolisthesis	7.5%
212	Medial Tibial Stress Syndrome	7.4%
213	Fragile X Syndrome	7.4%
214	Mitochondrial Myopathies	7.3%
215	Muscle Cramp	7.3%
216	Eosinophilia-Myalgia Syndrome	7.3%
217	Osteoporosis, Postmenopausal	7.3%
218	Muscle Rigidity	7.2%
219	Muscle Spasticity	7.2%
220	Cogwheel Rigidity	7.2%
221	Nuchal Rigidity	7.2%
222	Rickets	7.1%
223	Muscular Dystrophy, Duchenne	7.1%
224	Fetal Diseases	7.1%
225	Classical Lissencephalies and Subcortical Band Heterotopias	7%
226	Turner Syndrome	6.9%
227	Retinal Dysplasia	6.9%
228	Blepharophimosis	6.9%
229	Laryngostenosis	6.9%
230	Mouth Abnormalities	6.9%
231	Bone Diseases, Developmental	6.8%
232	Aniridia	6.8%
233	Esophageal Atresia	6.8%
234	Intestinal Atresia	6.8%
235	Horseshoe Kidney	6.8%
236	Acrodermatitis	6.7%
237	Lymphangiectasis, Intestinal	6.7%
238	Gianotti-Crosti Syndrome	6.7%
239	Epidermolysis Bullosa	6.7%
240	Rheumatoid Vasculitis	6.6%
241	Palatal Neoplasms	6.6%
242	Ichthyosis, X-Linked	6.6%
243	Smith-Lemli-Opitz Syndrome	6.6%
244	Primary Ciliary Dyskinesia	6.6%
245	Chronic Fatigue Syndrome	6.5%
246	Giant Cell Epulis	6.3%
247	Muscle Weakness	6.3%
248	Musculoskeletal Pain	6.2%
249	Arthralgia	6.2%
250	Myotonia Congenita	6.2%
251	Polyarthralgia	6.2%
252	Arthritis, Infectious	6.1%
253	Welander Distal Myopathy	6.1%
254	Mastoiditis	6%
255	Petrositis	6%
256	Anterior Compartment Syndrome	6%
257	Enthesopathy	6%
258	Arthritis, Experimental	6%
259	Abdominal Compartment Syndrome	6%
260	Ectopia Cordis	6%
261	Meningomyelocele	6%
262	Spina Bifida	6%
263	Polymyositis	6%
264	Single umbilical artery	6%
265	Cystic Fibrosis	6%
266	Choanal Atresia	5.9%
267	Tracheobronchomegaly	5.9%
268	Laryngocele	5.9%
269	Sicca Syndrome	5.9%
270	Sjogren's Syndrome	5.9%
271	Choledochal Cyst	5.9%
272	Hermaphroditism	5.9%
273	Disorders of Sex Development	5.9%
274	Cryptorchidism	5.8%
275	Hypospadias	5.8%
276	Central Nervous System Cysts	5.8%
277	Dandy-Walker Syndrome	5.7%
278	Klinefelter Syndrome	5.7%
279	POEMS Syndrome	5.7%
280	Synostosis	5.6%
281	Polycystic Kidney, Autosomal Dominant	5.6%
282	Myalgia	5.4%
283	Hypokalemic periodic paralysis	5.4%
284	Pseudoxanthoma Elasticum	5.4%
285	Sjogren-Larsson Syndrome	5.3%
286	Meconium Aspiration Syndrome	5.2%
287	Osteomalacia	5.1%
288	Hip Dislocation	5.1%
289	Shoulder Dislocation	5.1%
290	Hip Dysplasia	5.1%
291	Abdominal Cramps	5.1%
292	Amniotic Band Syndrome	5.1%
293	Asphyxia Neonatorum	5.1%
294	Infant, Premature, Diseases	5.1%
295	Infantile Colic	5.1%
296	Orbital Myositis	5.1%
297	Bladder Exstrophy	5%
298	Dysostoses	5%
299	Epispadias	5%
300	Dupuytren Contracture	5%
301	Multicystic Dysplastic Kidney	5%
302	Aortic coarctation	5%
303	Cor Triatriatum	5%
304	Coronary Vessel Anomalies	5%
305	Dental Enamel Hypoplasia	5%
306	Patent ductus arteriosus	5%
307	Ebstein Anomaly	5%
308	Heart Septal Defects	5%
309	Hypodontia	5%
310	Macrostomia	5%
311	Meningocele	5%
312	Microstomia	5%
313	Tetralogy of Fallot	5%
314	Transposition of Great Vessels	5%
315	Hypoplastic Left Heart Syndrome	5%
316	Pyomyositis	5%
317	May-Thurner Syndrome	5%
318	Encephalocele	5%
319	Kallmann Syndrome	5%
320	Dermal Sinus	5%
321	Spina Bifida Cystica	5%
322	Spina Bifida Occulta	5%
323	Lissencephaly	5%
324	Polymicrogyria	5%
325	Pachygyria	5%
326	Schizencephaly	5%
327	Periventricular Nodular Heterotopia	5%
328	Wolff-Parkinson-White Syndrome	4.9%
329	Charcot-Marie-Tooth Disease	4.9%
330	Xeroderma Pigmentosum	4.9%
331	Hyperkeratosis, Epidermolytic	4.9%
332	Zellweger Syndrome	4.6%
333	Hyperandrogenism	4.4%
334	Tuberous Sclerosis	4.4%
335	Antley-Bixler Syndrome Phenotype	4.3%
336	Long QT Syndrome	4.3%
337	Tricuspid Atresia	4.3%
338	Arrhythmogenic Right Ventricular Dysplasia	4.3%
339	Gonadal Dysgenesis	4.3%
340	Adrenogenital Syndrome	4.3%
341	Ovotesticular Disorders of Sex Development	4.3%
342	Neoplastic Syndromes, Hereditary	4.3%
343	Shoulder Pain	4.2%
344	Refsum Disease	4.2%
345	Aortopulmonary Septal Defect	4.1%
346	Double Outlet Right Ventricle	4.1%
347	Endocardial Cushion Defects	4.1%
348	Myocardial bridging	4.1%
349	Aorticopulmonary Septal Defect	4.1%
350	Anemia, Neonatal	4.1%
351	Pelger-Huet Anomaly	4.1%
352	Persistent Fetal Circulation Syndrome	4.1%
353	Werner Syndrome	4.1%
354	Myasthenic Syndromes, Congenital	4.1%
355	Umbilical hernia	4%
356	Anemia, Sickle Cell	3.8%
357	Thalassemia	3.8%
358	Nose Neoplasms	3.7%
359	Mitochondrial Encephalomyopathies	3.7%
360	Truncus Arteriosus, Persistent	3.7%
361	Albinism	3.7%
362	Renal Osteodystrophy	3.6%
363	Renal rickets	3.6%
364	Romano-Ward Syndrome	3.5%
365	Neonatal Abstinence Syndrome	3.5%
366	Fetal Growth Retardation	3.4%
367	Dermatomyositis	3.4%
368	Fetal Hypoxia	3.4%
369	Congenital nystagmus	3.4%
370	Fetal Alcohol Spectrum Disorders	3.4%
371	Familial Mediterranean Fever	3.4%
372	Toxoplasmosis, Congenital	3.3%
373	Syphilis, Congenital	3.3%
374	Rett Syndrome	3.3%
375	Mucopolysaccharidosis II	3.2%
376	Menkes Kinky Hair Syndrome	3%
377	Familial Hypophosphatemic Rickets	3%
378	Wiskott-Aldrich Syndrome	2.9%
379	Autoimmune Lymphoproliferative Syndrome	2.9%
380	Congenital Hyperinsulinism	2.9%
381	Chorioamnionitis	2.9%
382	Angioedemas, Hereditary	2.9%
383	Sickle Cell Trait	2.8%
384	Arteriovenous fistula	2.7%
385	Paralysis, Obstetric	2.7%
386	Retinopathy of Prematurity	2.7%
387	MELAS Syndrome	2.7%
388	Amino Acid Metabolism, Inborn Errors	2.7%
389	Carbohydrate Metabolism, Inborn Errors	2.7%
390	Metal Metabolism, Inborn Errors	2.7%
391	Progeria	2.7%
392	Lysosomal Storage Diseases	2.7%
393	Cytochrome-c Oxidase Deficiency	2.7%
394	Peroxisomal Disorders	2.7%
395	Neuronal Ceroid-Lipofuscinoses	2.7%
396	Bronchopulmonary Dysplasia	2.7%
397	Adrenoleukodystrophy	2.5%
398	Radicular Cyst	2.5%
399	Hepatolenticular Degeneration	2.4%
400	Fabry Disease	2.3%
401	Amyloid Neuropathies, Familial	2.3%
402	Respiratory Distress Syndrome, Newborn	2.3%
403	Denys-Drash Syndrome	2.3%
404	Cutis Laxa	2.3%
405	Retinitis Pigmentosa	2.2%
406	Pigmentary retinopathy	2.2%
407	Porokeratosis	2.2%
408	Keratoderma, Palmoplantar	2.2%
409	Acute Chest Syndrome	2.2%
410	Chronic granulomatous disease	2.2%
411	Glycogen storage disease type II	2.2%
412	Ophthalmia Neonatorum	2.2%
413	Galactosemias	2.2%
414	Urea Cycle Disorders, Inborn	2.2%
415	Tyrosinemias	2.2%
416	Hydrops Fetalis	2.2%
417	Mucopolysaccharidosis III	2%
418	Ataxia Telangiectasia	2%
419	Alkaptonuria	2%
420	Glycogen Storage Disease	2%
421	Hypophosphatasia	2%
422	Propionic acidemia	2%
423	Dihydropyrimidine Dehydrogenase Deficiency	2%
424	Cystinosis	2%
425	Optic Atrophy, Hereditary, Leber	2%
426	Hyperphosphaturia	2%
427	Duane Retraction Syndrome	2%
428	Porphyrias, Hepatic	1.9%
429	Canavan Disease	1.9%
430	Alexander Disease	1.9%
431	Peutz-Jeghers Syndrome	1.9%
432	Thrombasthenia	1.9%
433	Antithrombin III Deficiency	1.9%
434	Protein C Deficiency	1.9%
435	Brain Diseases, Metabolic, Inborn	1.9%
436	Afibrinogenemia	1.9%
437	Dystonia Musculorum Deformans	1.9%
438	Factor VII Deficiency	1.9%
439	Factor X Deficiency	1.9%
440	Factor XII Deficiency	1.9%
441	Hemophilia A	1.9%
442	Leukomalacia, Periventricular	1.9%
443	Activated Protein C Resistance	1.9%
444	Factor II deficiency	1.9%
445	Factor VIII Deficiency	1.9%
446	Factor V deficiency	1.9%
447	Factor XI Deficiency	1.9%
448	Hypoprothrombinemias	1.9%
449	Fanconi Anemia	1.9%
450	Nesidioblastosis	1.9%
451	Lafora Disease	1.9%
452	Unverricht-Lundborg Syndrome	1.9%
453	Anemia, Diamond-Blackfan	1.9%
454	Homocystinuria	1.8%
455	Gaucher Disease	1.8%
456	Leigh Disease	1.8%
457	Kearns-Sayre syndrome	1.7%
458	Multiple Endocrine Neoplasia	1.7%
459	Dermatitis, Atopic	1.7%
460	Hyaline Membrane Disease	1.7%
461	Hypolipoproteinemias	1.6%
462	Papillon-Lefevre Disease	1.6%
463	Glycogen Storage Disease Type I	1.6%
464	Glycogen Storage Disease Type V	1.6%
465	Hyperlipidemia, Familial Combined	1.6%
466	Tay-Sachs Disease	1.6%
467	Hyperlipoproteinemia Type III	1.6%
468	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.6%
469	Niemann-Pick Disease, Type C	1.6%
470	Kernicterus	1.5%
471	Behcet Syndrome	1.5%
472	Lactose Intolerance	1.4%
473	Variegate Porphyria	1.4%
474	Acute intermittent porphyria	1.4%
475	Porphyria Cutanea Tarda	1.4%
476	Hyperhomocysteinemia	1.4%
477	Renal Aminoacidurias	1.4%
478	Fanconi Syndrome	1.4%
479	Pseudohypoaldosteronism	1.4%
480	Liddle Syndrome	1.4%
481	Hyperlipoproteinemia Type IV	1.4%
482	Hyperlipoproteinemia Type V	1.4%
483	Hypoalphalipoproteinemias	1.4%
484	Huntington Disease	1.3%
485	Multiple Endocrine Neoplasia Type 1	1.2%
486	Friedreich Ataxia	1.2%
487	Renal tubular acidosis	1.2%
488	Nephroblastoma	1.2%
489	Cystinuria	1.2%
490	Adenomatous Polyposis Coli	1.1%
491	Glycosuria, Renal	1%

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