MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Paraparesis, Spastic

(UMLS:C0037771)

Definition:: Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.
UMLS ID:: C0037771
MeSH ID:: D020336

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.597.636.500.500

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.888.592.643.500.500

Synonym(s)

Paraparesis, Spastic

PARAPARESIS SPASTIC

Spastic paraparesis

spastic parapareses

spastic paraparesis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Bicuculline	12401631	CTD
2	Cytarabine	271037	CTD
3	Methadone	14622789	CTD
4	Morphine	View details 12401631 15502059 15673851 16551926 17366917	CTD
5	Nicorandil	16551926	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Decerebrate State	27%
2	Meningism	27%
3	Seizures	27%
4	Sensation Disorders	27%
5	Complex partial seizures	27%
6	Gait Disorders, Neurologic	27%
7	Neuromuscular Manifestations	27%
8	Asterixis	23.6%
9	Ballismus	23.6%
10	Pupil Disorders	22.5%
11	Neurobehavioral Manifestations	22.5%
12	Vertigo	21.5%
13	Psychophysiologic Disorders	18.9%
14	Sleep Wake Disorders	18.9%
15	Voice Disorders	18.4%
16	Voice Disturbance	18.4%
17	Gait Ataxia	17.5%
18	Orthostatic intolerance	16.7%
19	Anosmia	15.8%
20	Ataxia	15.8%
21	Athetosis	15.8%
22	Catalepsy	15.8%
23	Dystonia	15.8%
24	Hemiplegia	15.8%
25	Locked-In Syndrome	15.8%
26	Muscle Hypertonia	15.8%
27	Muscle hypotonia	15.8%
28	Myoclonus	15.8%
29	Myotonia	15.8%
30	Paraplegia	15.8%
31	Pseudobulbar Palsy	15.8%
32	Quadriplegia	15.8%
33	Spasm	15.8%
34	Spastic Paraplegia	15.8%
35	Status Epilepticus	15.8%
36	Taste Disorders	15.8%
37	Tremor	15.8%
38	Monoplegia	15.8%
39	Hypokinesia	15.8%
40	Bradykinesia	15.8%
41	Waxy flexibility	15.8%
42	Action Tremor	15.8%
43	Resting Tremor	15.8%
44	Dysosmia	15.8%
45	Quadriparesis	15.8%
46	Olfaction Disorders	15.8%
47	Myokymia	15.8%
48	Somatosensory Disorders	15.8%
49	Hyperkinesia	15.8%
50	Intention tremor	15.8%
51	Reflex, Abnormal	15.2%
52	Hyporeflexia	15.2%
53	Hyperreflexia	15.2%
54	Polydipsia	15.2%
55	Akathisia	15%
56	Restlessness	15%
57	Psychomotor Agitation	15%
58	Asthenia	14.9%
59	Body Temperature Changes	14.9%
60	Cyanosis	14.9%
61	Edema	14.9%
62	Failure to Thrive	14.9%
63	Fatigue	14.9%
64	Feminization	14.9%
65	Fetal Distress	14.9%
66	Motion Sickness	14.9%
67	Signs and Symptoms, Digestive	14.9%
68	Signs and Symptoms, Respiratory	14.9%
69	Skin Manifestations	14.9%
70	Chills	14.9%
71	Lassitude	14.9%
72	Pseudophakia	14.9%
73	Urological Manifestations	14.9%
74	Mobility Limitation	14.9%
75	Somnolence	14.9%
76	Abdominal Pain	14.6%
77	Neurogenic Inflammation	14.5%
78	Muscular Atrophy	14.3%
79	Chorea	13.9%
80	Gait Apraxia	13.4%
81	Muscle Weakness	13.4%
82	Vision Disorders	13.2%
83	Metamorphopsia	13.2%
84	Visual Impairment	13.2%
85	Renal Colic	13.1%
86	Anisocoria	12.9%
87	Confusion	12.9%
88	Facial paralysis	12.9%
89	Lethargy	12.9%
90	Memory Disorders	12.9%
91	Muscle Cramp	12.9%
92	Perceptual Disorders	12.9%
93	Psychomotor Disorders	12.9%
94	Tonic Pupil	12.9%
95	Anhedonia	12.9%
96	Disorientation	12.9%
97	Facial Paresis	12.9%
98	Memory Loss	12.9%
99	Hemisensory Neglect	12.9%
100	Dysacusis	12.9%
101	Respiratory Paralysis	12.7%
102	Tetany	12.6%
103	Ophthalmoplegia	12.4%
104	External Ophthalmoplegia	12.4%
105	Eye pain	11.9%
106	Eye Manifestations	11.8%
107	Cerebrospinal Fluid Otorrhea	11.6%
108	Cerebrospinal Fluid Rhinorrhea	11.6%
109	Pain	11.5%
110	Ache	11.5%
111	Cardiac Output, High	11.4%
112	Myocardial Stunning	11.4%
113	Reticulocytosis	11.4%
114	Low Cardiac Output Syndrome	11.4%
115	Back Pain	11.2%
116	Neck Pain	11.2%
117	Chest Pain	11.2%
118	Dizziness	11.2%
119	Facial Pain	11.2%
120	Flank Pain	11.2%
121	Headache	11.2%
122	Pain, Intractable	11.2%
123	Pelvic Pain	11.2%
124	Chronic pain	11.2%
125	Lightheadedness	11.2%
126	Pain, Referred	11.2%
127	Throbbing Headache	11.2%
128	Labor Pain	11.2%
129	Cancer Pain	11.2%
130	Nociceptive Pain	11.2%
131	Hoarseness	11.2%
132	Intermittent Claudication	11.1%
133	Dyskinesia, Drug-Induced	11%
134	Alice in Wonderland Syndrome	10.9%
135	Neuralgia	10.9%
136	Neuropathic pain	10.9%
137	Consciousness Disorders	10.9%
138	Mental Retardation	10.9%
139	Depressed Level of Consciousness	10.9%
140	Mental deficiency	10.9%
141	Intellectual Disability	10.9%
142	Catatonia	10.7%
143	Vocal Cord Paralysis	10.7%
144	Aphonia	10.6%
145	Dysphonia	10.6%
146	Pain, Postoperative	10.5%
147	Cranial nerve diseases	10.4%
148	Demyelinating Diseases	10.4%
149	Demyelination	10.4%
150	Neuromuscular Diseases	10.4%
151	Chronobiology Disorders	10.4%
152	Dysgeusia	10.4%
153	Formication	10.4%
154	Hyperalgesia	10.4%
155	Hyperesthesia	10.4%
156	Hypesthesia	10.4%
157	Language Disorders	10.4%
158	Numbness	10.4%
159	Paresthesia	10.4%
160	Trismus	10.4%
161	Epilepsia Partialis Continua	10.4%
162	Hypogeusia	10.4%
163	Brown-Sequard Syndrome	10.4%
164	Lockjaw	10.4%
165	Allodynia	10.4%
166	Ageusia	10.4%
167	Phantom pain	9.9%
168	Phantom Limb Pain	9.9%
169	Horner Syndrome	9.8%
170	Pathological Conditions, Anatomical	9.8%
171	Cerebellar Ataxia	9.6%
172	Torticollis	9.6%
173	Ophthalmoplegic Migraine	9.6%
174	Sarcopenia	9.3%
175	Tardive Dyskinesia	9.3%
176	Abdomen, Acute	9.2%
177	Alcohol Withdrawal Seizures	9.1%
178	Hypergammaglobulinemia	9.1%
179	Alexia	8.9%
180	Dyslexia	8.9%
181	Amblyopia	8.7%
182	Gastroparesis	8.5%
183	Diplopia	8.5%
184	Muscle Rigidity	8.5%
185	Muscle Spasticity	8.5%
186	Scotoma	8.5%
187	Photophobia	8.5%
188	Cogwheel Rigidity	8.5%
189	Hemifacial Spasm	8.5%
190	Amaurosis	8.5%
191	Blindness	8.5%
192	Nuchal Rigidity	8.5%
193	Motor Neuron Disease	8.4%
194	Agnosia	8.4%
195	Apraxias	8.4%
196	Hallucinations	8.4%
197	Hemianopsia	8.4%
198	Hyperacusis	8.4%
199	Tinnitus	8.4%
200	Visual Agnosia	8.4%
201	Anosognosia	8.4%
202	Wernicke-Korsakoff Syndrome	8.4%
203	Phonophobia	8.4%
204	Hearing Loss	8.4%
205	Progressive supranuclear palsy	8.3%
206	jaundice	8.2%
207	Trauma, Nervous System	8.1%
208	Anorexia	8.1%
209	Anoxia	8.1%
210	Constipation	8.1%
211	Diarrhea	8.1%
212	Dyspepsia	8.1%
213	Eructation	8.1%
214	Fever	8.1%
215	Flatulence	8.1%
216	Flushing	8.1%
217	Halitosis	8.1%
218	Heartburn	8.1%
219	Hiccough	8.1%
220	Hypercalciuria	8.1%
221	Hypercapnia	8.1%
222	Hyperphagia	8.1%
223	Nausea	8.1%
224	Pallor	8.1%
225	Vomiting	8.1%
226	Hypocapnia	8.1%
227	Dyschezia	8.1%
228	Hypoxia	8.1%
229	Hyperoxia	8.1%
230	Lower Urinary Tract Symptoms	8.1%
231	Hypoxemia	8.1%
232	Urinoma	8.1%
233	Nervous System Neoplasms	7.9%
234	Neurotoxicity Syndromes	7.9%
235	Agraphia	7.8%
236	Anomia	7.8%
237	Cluttering	7.8%
238	Language Development Disorders	7.8%
239	Speech Disorders	7.8%
240	Syncope	7.8%
241	Stupor	7.8%
242	Dysgraphia	7.8%
243	Presyncope	7.8%
244	Dyslalia	7.8%
245	Dysmenorrhea	7.7%
246	Failed Back Surgery Syndrome	7.7%
247	Persistent Vegetative State	7.5%
248	Low Back Pain	7.4%
249	Visceral Pain	7.4%
250	Postoperative Nausea and Vomiting	7.4%
251	Subacute Combined Degeneration	7.4%
252	Sleep Deprivation	7.4%
253	Stiff-Person Syndrome	7.3%
254	Multiple System Atrophy	7.2%
255	Akathisia, Drug-Induced	7.1%
256	Amnesia	7.1%
257	Delirium	7.1%
258	Dissociative Amnesia	7.1%
259	Color blindness	7.1%
260	Global Amnesia	7.1%
261	Metatarsalgia	7%
262	Ocular Motility Disorders	7%
263	Cyclophoria	7%
264	Mastodynia	6.8%
265	Eye Hemorrhage	6.8%
266	Jet Lag Syndrome	6.8%
267	Breakthrough Pain	6.8%
268	Restless Legs Syndrome	6.7%
269	Sciatica	6.7%
270	Polyradiculoneuropathy	6.7%
271	Polyradiculoneuritis	6.7%
272	Hemoptysis	6.6%
273	Encephalomyelitis	6.6%
274	Prion Diseases	6.6%
275	Autonomic Dysreflexia	6.6%
276	Complex Regional Pain Syndromes	6.6%
277	Ecchymosis	6.6%
278	Petechiae	6.6%
279	Purpura	6.6%
280	Aphasia	6.4%
281	Articulation Disorders	6.4%
282	Echolalia	6.4%
283	Stuttering	6.4%
284	Dysphasia	6.4%
285	Body Weight	6.3%
286	Amaurosis Fugax	6.3%
287	Blindness, Cortical	6.3%
288	Dyscalculia	6.3%
289	Apnea	6.2%
290	Cheyne-Stokes Respiration	6.2%
291	Dyspnea	6.2%
292	Hyperventilation	6.2%
293	Mouth Breathing	6.2%
294	Pruritus	6.2%
295	Sneezing	6.2%
296	Erythema	6.2%
297	Necrolytic Migratory Erythema	6.2%
298	Tachypnea	6.2%
299	Deafness	6.2%
300	Hearing Loss, Sudden	6.2%
301	Gerstmann Syndrome	6.2%
302	Hearing Loss, Bilateral	6.2%
303	Hearing Loss, High-Frequency	6.2%
304	Hearing Loss, Mixed Conductive-Sensorineural	6.2%
305	Prosopagnosia	6.2%
306	Apraxia, Ideomotor	6.2%
307	Charles Bonnet Syndrome	6.2%
308	Hearing Loss, Unilateral	6.2%
309	Complete Hearing Loss	6.2%
310	Alien Hand Syndrome	6.2%
311	Deaf Mutism	6.2%
312	Vascular Remodeling	6.1%
313	Edema, Cardiac	6.1%
314	Mental Fatigue	6.1%
315	Hirsutism	6.1%
316	Hypoventilation	6.1%
317	Auditory Perceptual Disorders	6.1%
318	Body Weight Changes	6%
319	Brain Death	6%
320	Spinal Muscular Atrophy	5.9%
321	Progressive Muscular Atrophy	5.9%
322	Amnesia, Transient Global	5.9%
323	Dysarthria	5.8%
324	Musculoskeletal Pain	5.8%
325	Marchiafava-Bignami Disease	5.8%
326	Toothache	5.7%
327	Arthralgia	5.7%
328	Polyarthralgia	5.7%
329	Amyotrophic Lateral Sclerosis	5.6%
330	Epistaxis	5.6%
331	Parkinson Disease	5.6%
332	Spinal Cord Injuries	5.5%
333	Brain Diseases	5.5%
334	Dysautonomia	5.5%
335	Meningitis	5.5%
336	Movement Disorders	5.5%
337	Pachymeningitis	5.5%
338	Spinal Cord Diseases	5.5%
339	Vagus Nerve Disorder	5.5%
340	Glossopharyngeal Neuralgia	5.5%
341	Abducens Nerve Diseases	5.5%
342	Heavy Metal Poisoning, Nervous System	5.5%
343	Neuromuscular Junction Diseases	5.5%
344	Tauopathies	5.5%
345	Trochlear Nerve Diseases	5.5%
346	Peripheral Nervous System Diseases	5.5%
347	Opsoclonus-Myoclonus Syndrome	5.5%
348	Meningoencephalitis	5.4%
349	Peripheral Nerve Injuries	5.4%
350	Myasthenia Gravis	5.3%
351	Mutism	5.3%
352	Selective Mutism	5.3%
353	Retrograde amnesia	5.2%
354	Amnesia, Anterograde	5.2%
355	Pleural Rub	5%
356	Rales	5%
357	Respiratory Sounds	5%
358	Rhonchi	5%
359	Stridor	5%
360	Wheezing	5%
361	Ascites	5%
362	Calculi	5%
363	Fibrosis	5%
364	Gliosis	5%
365	Growth Disorders	5%
366	Hemorrhage	5%
367	Hernia	5%
368	Hyperbilirubinemia	5%
369	Hyperplasia	5%
370	Hypertrophy	5%
371	Hypomenorrhea	5%
372	Inflammation	5%
373	Intraoperative Complications	5%
374	Ischemia	5%
375	Lithiasis	5%
376	Malacoplakia	5%
377	Menstruation Disturbances	5%
378	Metaplasia	5%
379	Nails, Malformed	5%
380	Nerve Degeneration	5%
381	Ochronosis	5%
382	Polymenorrhea	5%
383	polyps	5%
384	Postoperative Complications	5%
385	Rupture, Spontaneous	5%
386	Sclerosis	5%
387	Shock	5%
388	Ulcer	5%
389	Enterocele	5%
390	Hyperammonemia	5%
391	Hyperamylasemia	5%
392	Teratogenesis	5%
393	Atheroma	5%
394	Cardiac Death	5%
395	Hypovolemia	5%
396	Hyperuricemia	5%
397	Leukoaraiosis	5%
398	Stenosis	5%
399	Facial asymmetry	5%
400	Dysbacteriosis	5%
401	Delayed Graft Function	5%
402	Cirrhosis	5%
403	Plaque, Amyloid	5%
404	Plaque, Atherosclerotic	5%
405	Neointima	5%
406	Dysbiosis	5%
407	Dandy-Walker Syndrome	4.9%
408	Livedo Reticularis	4.9%
409	Lewy Body Disease	4.9%
410	Pneumocephalus	4.9%
411	Poliomyelitis	4.9%
412	Myelitis	4.9%
413	Progressive bulbar palsy	4.9%
414	Bulbar palsy	4.9%
415	Oliguria	4.9%
416	Polyuria	4.9%
417	Proteinuria	4.9%
418	Guillain-Barre Syndrome	4.9%
419	Jaundice, Obstructive	4.8%
420	Bulimia	4.8%
421	Dysuria	4.8%
422	Fever of Unknown Origin	4.8%
423	Nocturia	4.8%
424	Snoring	4.8%
425	Prostatism	4.8%
426	Underweight	4.8%
427	Overweight	4.8%
428	Alexia, Pure	4.7%
429	Myalgia	4.7%
430	Chronic Fatigue Syndrome	4.6%
431	Neuroleptic Malignant Syndrome	4.6%
432	Myelinolysis, Central Pontine	4.6%
433	Sleep Disorders, Circadian Rhythm	4.6%
434	Striatonigral Degeneration	4.6%
435	Lambert-Eaton Myasthenic Syndrome	4.6%
436	Angina Pectoris	4.5%
437	Causalgia	4.5%
438	Botulism	4.4%
439	Central Nervous System Cysts	4.4%
440	Coma, Post-Head Injury	4.4%
441	Central Nervous System Infection	4.4%
442	Myopathy	4.4%
443	Optic Neuropathy	4.4%
444	Epidural Abscess	4.3%
445	Olfactory Nerve Injuries	4.3%
446	Myelitis, Transverse	4.2%
447	Facial Nerve Diseases	4.2%
448	Craniocerebral Trauma	4.2%
449	Parasomnia	4.2%
450	Dyssomnias	4.2%
451	MPTP Poisoning	4.2%
452	Gagging	4.2%
453	Vestibulocochlear Nerve Diseases	4.1%
454	Hydranencephaly	4.1%
455	Neural Tube Defects	4.1%
456	Tethered Cord Syndrome	4.1%
457	Central Nervous System Neoplasms	4.1%
458	Iniencephaly	4.1%
459	Craniorachischisis	4.1%
460	Exencephaly	4.1%
461	Septo-Optic Dysplasia	4.1%
462	Cortical Dysplasia	4.1%
463	Malformations of Cortical Development	4.1%
464	Sweating, Gustatory	4.1%
465	Auriculotemporal Syndrome	4.1%
466	Leukoencephalitis, Acute Hemorrhagic	4.1%
467	Infarction	4.1%
468	Postoperative Hemorrhage	4.1%
469	Shock, Hemorrhagic	4.1%
470	Systemic Inflammatory Response Syndrome	4.1%
471	Incisional hernia	4.1%
472	Encephalomyelitis, Acute Disseminated	4.1%
473	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.1%
474	Reflex Sympathetic Dystrophy	4%
475	Subdural Effusion	4%
476	Parkinsonian Disorders	4%
477	Nocturnal Myoclonus Syndrome	4%
478	Miller Fisher Syndrome	4%
479	Shy-Drager Syndrome	3.9%
480	Brain Injuries	3.9%
481	Cyst	3.9%
482	Extravasation of Diagnostic and Therapeutic Materials	3.9%
483	Neoplastic Processes	3.9%
484	Brain Neoplasms	3.9%
485	Multiple Sclerosis	3.9%
486	Spinal Cord Neoplasms	3.9%
487	Neuromyelitis Optica	3.9%
488	Hematemesis	3.9%
489	Purpura Fulminans	3.9%
490	Leukoplakia	3.8%
491	Necrosis	3.8%
492	Granulomatosis, Orofacial	3.8%
493	Pigmentation Disorders	3.8%
494	Respiratory Aspiration	3.8%
495	Airway Remodeling	3.8%
496	Dystonia Musculorum Deformans	3.8%
497	Shoulder Pain	3.7%
498	Acantholysis	3.7%
499	Chromosome Aberrations	3.7%
500	Dehydration	3.7%
501	Granuloma	3.7%
502	Leukocytosis	3.7%
503	Pleocytosis	3.7%
504	Ventricular Remodeling	3.7%
505	Facial Nerve Injuries	3.7%
506	Alopecia	3.7%
507	Ataxia Telangiectasia	3.7%
508	Androgenetic Alopecia	3.7%
509	Morning Sickness	3.7%
510	Weight Gain	3.6%
511	Meningocele	3.6%
512	Encephalocele	3.6%
513	Birth Weight	3.4%
514	Kearns-Sayre syndrome	3.4%
515	Leukoencephalopathy, Progressive Multifocal	3.4%
516	Paraneoplastic Encephalomyelitis	3.4%
517	Angina, Unstable	3.4%
518	Uveomeningoencephalitic Syndrome	3.3%
519	Vasculitis, Central Nervous System	3.3%
520	Brain Abscess	3.3%
521	Scrapie	3.3%
522	Sturge-Weber Syndrome	3.3%
523	Central Cord Syndrome	3.3%
524	Alcohol-Induced Disorders, Nervous System	3.3%
525	Cri-du-Chat Syndrome	3.3%
526	Down Syndrome	3.3%
527	Trisomy 21	3.3%
528	Presenile dementia	3.3%
529	Senile dementia	3.3%
530	Meningitis, Bacterial	3.3%
531	Meningitis, Fungal	3.3%
532	Limbic Encephalitis	3.2%
533	Myasthenia Gravis, Autoimmune, Experimental	3.2%
534	Akinetic Mutism	3.2%
535	Anoxic Encephalopathy	3.2%
536	Arachnoiditis	3.2%
537	Basal Ganglia Diseases	3.2%
538	Brain Damage, Chronic	3.2%
539	Cerebellar Diseases	3.2%
540	Encephalitis	3.2%
541	Encephalomalacia	3.2%
542	Epilepsy	3.2%
543	Hydrocephalus	3.2%
544	Congenital Hydrocephalus	3.2%
545	Hypothalamic Diseases	3.2%
546	Aseptic Meningitis	3.2%
547	Neuritis	3.2%
548	Polyneuritis	3.2%
549	Radiculitis	3.2%
550	Syringomyelia	3.2%
551	Thalamic Diseases	3.2%
552	Intracranial Hypertension	3.2%
553	Polyneuropathy	3.2%
554	Williams Syndrome	3.2%
555	Mononeuritis	3.2%
556	Aura	3.2%
557	Leukoencephalopathy	3.2%
558	Essential Tremor	3.2%
559	Neuroaxonal Dystrophies	3.2%
560	Familial Tremor	3.2%
561	Headache Disorders	3.2%
562	Mononeuropathies	3.2%
563	Intracranial Hypotension	3.2%
564	Brachial Plexus Neuropathies	3.2%
565	Radiculopathy	3.2%
566	Mononeuropathy Multiplex	3.2%
567	Nerve Root Compression	3.2%
568	Brain Edema	3.2%
569	Brain Hypoxia	3.2%
570	Aqueductal Stenosis	3.2%
571	Pneumorrhachis	3.2%
572	Writer's Cramp	3.2%
573	Acrodynia	3.2%
574	Epilepsy, Post-Traumatic	3.2%
575	Meige Syndrome	3.2%
576	Brachial Plexus Neuritis	3.2%
577	Neuralgic Amyotrophy	3.2%
578	Cerebral Ventriculitis	3.2%
579	Emaciation	3.2%
580	Genomic Instability	3.1%
581	Huntington Disease	3.1%
582	Tuberous Sclerosis	3.1%
583	Charcot-Marie-Tooth Disease	3%
584	Fetal Hypoxia	3%
585	Diverticulum	3%
586	Diverticulosis	3%
587	Azotemia	2.9%
588	Dyspnea, Paroxysmal	2.9%
589	Urinary Incontinence	2.9%
590	Albuminuria	2.9%
591	Hemoglobinuria	2.9%
592	Rett Syndrome	2.9%
593	Lupus Vasculitis, Central Nervous System	2.9%
594	Thrombocytopenic purpura	2.8%
595	Canavan Disease	2.8%
596	Alexander Disease	2.8%
597	Lafora Disease	2.8%
598	Unverricht-Lundborg Syndrome	2.8%
599	Tarsal Tunnel Syndrome	2.8%
600	Cauda Equina Syndrome	2.8%
601	Posterior Leukoencephalopathy Syndrome	2.8%
602	Posterior reversible encephalopathy syndrome	2.8%
603	Prader-Willi Syndrome	2.8%
604	Angina Pectoris, Variant	2.8%
605	Purpura, Hyperglobulinemic	2.8%
606	Smith-Magenis syndrome	2.8%
607	Dural Arteriovenous Fistula	2.8%
608	Chromosomal Instability	2.8%
609	Hydrops Fetalis	2.7%
610	Myotonia Congenita	2.7%
611	Paraneoplastic Cerebellar Degeneration	2.7%
612	Acute Disease	2.7%
613	Acute-Phase Reaction	2.7%
614	Amenorrhea	2.7%
615	Chronic disease	2.7%
616	Critical Illness	2.7%
617	Sudden death	2.7%
618	Fat necrosis	2.7%
619	Gangrene	2.7%
620	Graft Occlusion, Vascular	2.7%
621	Granuloma, Plasma Cell	2.7%
622	Hematoma	2.7%
623	Diaphragmatic Hernia	2.7%
624	Iatrogenic Disease	2.7%
625	Intestinal Polyps	2.7%
626	Multiple Organ Failure	2.7%
627	Oligomenorrhea	2.7%
628	Premenstrual syndrome	2.7%
629	Recurrence	2.7%
630	Retrograde Degeneration	2.7%
631	Retroperitoneal fibrosis	2.7%
632	Serositis	2.7%
633	Splenomegaly	2.7%
634	Subcutaneous Emphysema	2.7%
635	Surgical Wound Dehiscence	2.7%
636	Syndrome	2.7%
637	Wallerian Degeneration	2.7%
638	Pyogenic granuloma	2.7%
639	Exsanguination	2.7%
640	Disease Progression	2.7%
641	Seroma	2.7%
642	Premenstrual Tension	2.7%
643	Delayed Emergence from Anesthesia	2.7%
644	Infant Death	2.7%
645	Anastomotic Leak	2.7%
646	Intraoperative Awareness	2.7%
647	Neuritis, Autoimmune, Experimental	2.7%
648	Fetal Weight	2.7%
649	Cerebellar Neoplasms	2.7%
650	Creutzfeldt-Jakob disease	2.6%
651	Basal Ganglia Cerebrovascular Disease	2.6%
652	Dementia, Vascular	2.6%
653	Brain Hemorrhage, Traumatic	2.6%
654	Menorrhagia	2.6%
655	Brain Injuries, Diffuse	2.6%
656	Traumatic Brain Injury	2.6%
657	Supratentorial Neoplasms	2.6%
658	Multiple Sclerosis, Chronic Progressive	2.6%
659	Multiple Sclerosis, Relapsing-Remitting	2.6%
660	Waterhouse-Friderichsen Syndrome	2.6%
661	Cardiotoxicity	2.5%
662	Friedreich Ataxia	2.5%
663	Hematoma, Subdural	2.5%
664	Hematoma, Epidural, Cranial	2.5%
665	Brain Diseases, Metabolic	2.5%
666	Cerebrovascular Disorders	2.5%
667	Myositis	2.5%
668	Optic Atrophy	2.5%
669	Optic Neuritis	2.5%
670	Papilledema	2.5%
671	Strabismus	2.5%
672	Tolosa-Hunt Syndrome	2.5%
673	Cerebrovascular Insufficiency	2.5%
674	Isaacs syndrome	2.5%
675	Arsenic Poisoning	2.5%
676	Dementia	2.5%
677	Myotonic Disorders	2.5%
678	Central Nervous System Fungal Infections	2.5%
679	Conus Medullaris Syndrome	2.5%
680	Myasthenic Syndromes, Congenital	2.5%
681	Spinal Cord Vascular Diseases	2.5%
682	Diabetic Neuropathies	2.4%
683	Facial Injuries	2.4%
684	Facial Neuralgia	2.4%
685	Diabetic Amyotrophy	2.4%
686	Diabetic Autonomic Neuropathy	2.4%
687	Sleep Talking	2.4%
688	Manganese Poisoning	2.4%
689	Sleep Disorders, Intrinsic	2.4%
690	Meningeal Neoplasms	2.4%
691	Meningomyelocele	2.4%
692	Spina Bifida	2.4%
693	Mercury Poisoning, Nervous System	2.4%
694	Lead Poisoning, Nervous System	2.4%
695	Vestibular Neuronitis	2.4%
696	Carotid Artery Injuries	2.4%
697	Hyperemesis Gravidarum	2.4%
698	Sudden infant death syndrome	2.4%
699	Obesity	2.4%
700	Myoclonic Epilepsy	2.4%
701	Epilepsy, Temporal Lobe	2.4%
702	Epilepsy, Rolandic	2.4%
703	Benign Rolandic Epilepsy	2.4%
704	Cachexia	2.4%
705	Hepatolenticular Degeneration	2.4%
706	Myotonic Dystrophy	2.4%
707	Tuberculosis, Meningeal	2.3%
708	Carpal Tunnel Syndrome	2.3%
709	Vascular Headaches	2.3%
710	neurofibroma	2.2%
711	Hypoxia-Ischemia, Brain	2.2%
712	Rubinstein-Taybi Syndrome	2.2%
713	Leukomalacia, Periventricular	2.2%
714	Asphyxia	2.1%
715	Granuloma, Respiratory Tract	2.1%
716	Shock, Traumatic	2.1%
717	Respiratory Tract Fistula	2.1%
718	Cerebral Palsy	2.1%
719	Epilepsies, Partial	2.1%
720	Epilepsy, Generalized	2.1%
721	Pseudotumor Cerebri	2.1%
722	Sciatic Neuropathy	2.1%
723	Hypertensive Encephalopathy	2.1%
724	Ulnar Neuropathies	2.1%
725	Lesion of Sciatic Nerve	2.1%
726	Simple Partial Seizures	2.1%
727	Epilepsy, Reflex	2.1%
728	Ulnar Neuritis	2.1%
729	Radial nerve compression	2.1%
730	Radial Tunnel Syndrome	2.1%
731	Peroneal Neuropathies	2.1%
732	Radial Neuropathy	2.1%
733	Median Neuropathy	2.1%
734	Sciatic Nerve Palsy	2.1%
735	Femoral Neuropathy	2.1%
736	Tibial Neuropathy	2.1%
737	Ulnar Nerve Palsy	2.1%
738	Postural Orthostatic Tachycardia Syndrome	2.1%
739	Radial nerve palsy	2.1%
740	Headache Disorders, Primary	2.1%
741	Headache Disorders, Secondary	2.1%
742	Medication overuse headache	2.1%
743	Adrenoleukodystrophy	2.1%
744	Basal Ganglia Hemorrhage	2.1%
745	Vertebral Artery Dissection	2.1%
746	Hand-Arm Vibration Syndrome	2.1%
747	Disease susceptibility	2.1%
748	Fetal Death	2.1%
749	Foreign-Body Reaction	2.1%
750	Gastrointestinal Hemorrhage	2.1%
751	Cardiomegaly	2.1%
752	Hemarthrosis	2.1%
753	Hemoperitoneum	2.1%
754	Hemothorax	2.1%
755	Hepatomegaly	2.1%
756	Neoplasm Invasiveness	2.1%
757	Neoplasm Metastasis	2.1%
758	Neoplasm Recurrence, Local	2.1%
759	Parovarian Cyst	2.1%
760	Postpericardiotomy Syndrome	2.1%
761	Prosthesis Failure	2.1%
762	Reperfusion Injury	2.1%
763	Spermatocele	2.1%
764	Oral Fistula	2.1%
765	Injection Site Reaction	2.1%
766	Retrobulbar Hemorrhage	2.1%
767	Cutaneous Fistula	2.1%
768	Aseptic Necrosis of Bone	2.1%
769	Peritoneal Fibrosis	2.1%
770	Carcinogenesis	2.1%
771	Perinatal death	2.1%
772	Infusion site reaction	2.1%
773	Cardiac Hypertrophy	2.1%
774	Nephrogenic Fibrosing Dermopathy	2.1%
775	Corneal Endothelial Cell Loss	2.1%
776	Encapsulating Peritoneal Sclerosis	2.1%
777	Vasoplegia	2.1%
778	Suppuration	2.1%
779	Nephrogenic Systemic Fibrosis	2.1%
780	Metastasis	2.1%
781	Fragile X Syndrome	2.1%
782	Tinea Pedis	2.1%
783	Sinus Arrhythmia	2%
784	Atrial Fibrillation	2%
785	Atrial Flutter	2%
786	Dental Pulp Necrosis	2%
787	Granuloma, Foreign-Body	2%
788	Mediastinal Emphysema	2%
789	Surgical Wound Infection	2%
790	Ventricular Fibrillation	2%
791	Ventricular Flutter	2%
792	Parasystole	2%
793	Paroxysmal atrial fibrillation	2%
794	Facies	2%
795	Bradycardia	2%
796	Embryo Loss	2%
797	Afferent Loop Syndrome	2%
798	Sex Chromosome Aberrations	2%
799	Short Bowel Syndrome	2%
800	Uterine hemorrhage	2%
801	Vaginal Fistula	2%
802	Rectocele	2%
803	No-Reflow Phenomenon	2%
804	Fibromyalgia	2%
805	Optic Neuropathy, Ischemic	2%
806	Anterior Ischemic Optic Neuropathy	2%
807	Central Nervous System Bacterial Infections	2%
808	Medial Tibial Stress Syndrome	2%
809	Brain Concussion	2%
810	Optic Nerve Glioma	2%
811	Facial Hemiatrophy	2%
812	Melkersson-Rosenthal Syndrome	2%
813	Mitochondrial Myopathies	2%
814	Juvenile Myoclonic Epilepsy	2%
815	Myoclonic Epilepsies, Progressive	2%
816	Refsum Disease	2%
817	Eosinophilia-Myalgia Syndrome	2%
818	Toxoplasmosis, Cerebral	2%
819	Sleep Bruxism	2%
820	Anencephaly	2%
821	Subarachnoid Hemorrhage	1.9%
822	Cerebral Hemorrhage	1.9%
823	Alstrom Syndrome	1.9%
824	Urge Incontinence	1.9%
825	Cubital Tunnel Syndrome	1.9%
826	Diffuse Axonal Injury	1.9%
827	Brain Stem Neoplasms	1.9%
828	Meningitis, Cryptococcal	1.9%
829	Meningitis, Listeria	1.9%
830	Meningitis, Haemophilus	1.9%
831	Meningitis, Pneumococcal	1.9%
832	Frontotemporal dementia	1.9%
833	Kernicterus	1.9%
834	Mitochondrial Encephalomyopathies	1.9%
835	Hematoma, Subdural, Intracranial	1.8%
836	Hematoma, Subdural, Chronic	1.8%
837	Hematoma, Subdural, Acute	1.8%
838	Purpura, Thrombotic Thrombocytopenic	1.8%
839	Amyloid Neuropathies, Familial	1.8%
840	Pituitary Adenoma	1.8%
841	Pituitary Neoplasms	1.8%
842	Acoustic Neuroma	1.8%
843	Putaminal Hemorrhage	1.7%
844	Drowning	1.7%
845	Pituitary Diseases	1.7%
846	Nasal Polyps	1.7%
847	Duane Retraction Syndrome	1.7%
848	Mobius Syndrome	1.7%
849	Bell Palsy	1.7%
850	Fetal Growth Retardation	1.7%
851	DNA Degradation, Necrotic	1.7%
852	Aneuploidy	1.7%
853	Polyploidy	1.7%
854	Microsatellite Instability	1.7%
855	Herpes Zoster Oticus	1.6%
856	Thoracic Outlet Syndrome	1.6%
857	Familial Periodic Paralysis	1.6%
858	Heart Block	1.6%
859	Tachycardia	1.6%
860	Tachyarrhythmia	1.6%
861	Cicatrix	1.6%
862	Hematuria	1.6%
863	Urinary Calculi	1.6%
864	Granuloma Annulare	1.6%
865	Chromosome Breakage	1.6%
866	Pituitary Apoplexy	1.6%
867	Carotid Artery Diseases	1.6%
868	Brain Ischemia	1.6%
869	Esotropia	1.6%
870	Exotropia	1.6%
871	Hypotension, Orthostatic	1.6%
872	Sleep Apnea Syndromes	1.6%
873	Cerebrovascular accident	1.6%
874	Polymyositis	1.6%
875	Kluver-Bucy Syndrome	1.6%
876	Vasospasm, Intracranial	1.6%
877	Spinal Cord Ischemia	1.6%
878	Intracranial Arterial Diseases	1.6%
879	Post-Exercise Hypotension	1.6%
880	Giant Cell Arteritis	1.6%
881	Temporal Arteritis	1.6%
882	Shock, Cardiogenic	1.6%
883	Chromosome Fragility	1.6%
884	Endotoxic shock	1.6%
885	Septic Shock	1.6%
886	Toxic Shock Syndrome	1.6%
887	Menkes Kinky Hair Syndrome	1.6%
888	Disorders of Excessive Somnolence	1.6%
889	Sleep Initiation and Maintenance Disorders	1.6%
890	Night Terrors	1.6%
891	Somnambulism	1.6%
892	Trigeminal Nerve Disorder	1.6%
893	Transient Insomnia	1.6%
894	Sleep Paralysis	1.6%
895	Chronic Insomnia	1.6%
896	REM Sleep Behavior Disorder	1.6%
897	Hypersomnia	1.6%
898	Tissue Adhesions	1.6%
899	Colonic Polyps	1.6%
900	Brain Contusion	1.6%
901	Hematoma, Epidural, Spinal	1.6%
902	Dermal Sinus	1.6%
903	Spina Bifida Cystica	1.6%
904	Spina Bifida Occulta	1.6%
905	Meningeal Carcinomatosis	1.6%
906	Lissencephaly	1.6%
907	Polymicrogyria	1.6%
908	Pachygyria	1.6%
909	Schizencephaly	1.6%
910	Lead Poisoning, Nervous System, Childhood	1.6%
911	Lead Poisoning, Nervous System, Adult	1.6%
912	Brain Infarction	1.6%
913	Periventricular Nodular Heterotopia	1.6%
914	Tuberculosis, Central Nervous System	1.6%
915	Classical Lissencephalies and Subcortical Band Heterotopias	1.6%
916	Polyradiculopathy	1.6%
917	Post-Traumatic Headache	1.6%
918	Tension Headache	1.6%
919	Epilepsy, Complex Partial	1.6%
920	Migraine Disorders	1.6%
921	Abdominal Migraine	1.6%
922	Status Migrainosus	1.6%
923	Cervicogenic Headache	1.6%
924	Subarachnoid Hemorrhage, Traumatic	1.6%
925	Carotid Artery, Internal, Dissection	1.6%
926	Pediatric Obesity	1.6%
927	Choroid Plexus Papilloma	1.6%
928	Subacute Sclerosing Panencephalitis	1.5%
929	Autoimmune thrombocytopenia	1.5%
930	Immune thrombocytopenic purpura	1.5%
931	Mucopolysaccharidosis II	1.4%
932	Giant Cell Epulis	1.4%
933	Neuronal Ceroid-Lipofuscinoses	1.4%
934	Infarction, Middle Cerebral Artery	1.4%
935	Infarction, Anterior Cerebral Artery	1.4%
936	Infarction, Posterior Cerebral Artery	1.4%
937	Sick Sinus Syndrome	1.4%
938	Trisomy	1.4%
939	Leukoplakia, Oral	1.4%
940	Long QT Syndrome	1.4%
941	Eye Injuries	1.3%
942	Micronuclei, Chromosome-Defective	1.3%
943	Cluster Headache	1.3%
944	Migraine with Aura	1.3%
945	Familial Hemiplegic Migraine	1.3%
946	Chronic Paroxysmal Hemicrania	1.3%
947	SUNCT Syndrome	1.3%
948	Paroxysmal Hemicrania	1.3%
949	Cerebral Infarction	1.3%
950	Brain Stem Infarctions	1.3%
951	Muscular Dystrophy	1.3%
952	Congenital nystagmus	1.3%
953	Orbital Myositis	1.3%
954	MELAS Syndrome	1.3%
955	Reye Syndrome	1.3%
956	Neuroaspergillosis	1.3%
957	Pyomyositis	1.3%
958	Intracranial Embolism and Thrombosis	1.3%
959	Hepatic Encephalopathy	1.3%
960	Moyamoya Disease	1.3%
961	Optic Atrophy, Hereditary, Leber	1.3%
962	Aicardi's syndrome	1.3%
963	Neurofibrosarcoma	1.2%
964	Biliary Fistula	1.2%
965	Cross Infection	1.2%
966	Gastric Fistula	1.2%
967	Hyphema	1.2%
968	Retinal Neovascularization	1.2%
969	Septicemia	1.2%
970	Vitreous Hemorrhage	1.2%
971	Congenital diaphragmatic hernia	1.2%
972	Sepsis	1.2%
973	Cockayne Syndrome	1.2%
974	Empty Sella Syndrome	1.2%
975	Hyperpituitarism	1.2%
976	Hypopituitarism	1.2%
977	Hypophysitis	1.2%
978	Alcohol Withdrawal Delirium	1.2%
979	Abscess	1.2%
980	Dental Fistula	1.2%
981	Empyema	1.2%
982	Femur Head Necrosis	1.2%
983	Fetal Resorption	1.2%
984	Lymphatic Metastasis	1.2%
985	Neoplasms, Unknown Primary	1.2%
986	Oroantral Fistula	1.2%
987	Peptic Ulcer Hemorrhage	1.2%
988	Sudden Cardiac Death	1.2%
989	Left Ventricular Hypertrophy	1.2%
990	Leukemic Infiltration	1.2%
991	Right Ventricular Hypertrophy	1.2%
992	Premenstrual Dysphoric Disorder	1.2%
993	Choroidal Neovascularization	1.2%
994	Primary Graft Dysfunction	1.2%
995	Neoplasm Micrometastasis	1.2%
996	Dumping Syndrome	1.2%
997	Rectal Prolapse	1.2%
998	Uterine Prolapse	1.2%
999	Cicatrix, Hypertrophic	1.2%
1000	Vaginal Prolapse	1.2%
1001	Sinus Arrest, Cardiac	1.2%
1002	Cerebral Arterial Diseases	1.2%
1003	Metrorrhagia	1.2%
1004	Vertebrobasilar Insufficiency	1.2%
1005	Anterior Spinal Artery Syndrome	1.2%
1006	Basilar Artery Stenosis	1.2%
1007	Vertebral Artery Stenosis	1.2%
1008	Sleep Apnea, Obstructive	1.2%
1009	Sleep Apnea, Central	1.2%
1010	Intracranial Hemorrhage, Hypertensive	1.2%
1011	Transient Cerebral Ischemia	1.2%
1012	Narcolepsy	1.2%
1013	Trigeminal Neuralgia	1.2%
1014	Kleine-Levin Syndrome	1.2%
1015	Lateral Medullary Syndrome	1.2%
1016	Eosinophilic Granuloma	1.2%
1017	West Nile Fever	1.2%
1018	Pseudorabies	1.1%
1019	Vesicovaginal Fistula	1.1%
1020	Holoprosencephaly	1.1%
1021	Brain Diseases, Metabolic, Inborn	1.1%
1022	POEMS Syndrome	1.1%
1023	Meningioma	1.1%
1024	Microcephaly	1.1%
1025	Macrocephaly	1.1%
1026	Neurosyphilis	1.1%
1027	Hypokalemic periodic paralysis	1.1%
1028	Porencephaly	1.1%
1029	Hematoma, Subdural, Spinal	1.1%
1030	Hyperprolactinemia	1%
1031	Bronchial Fistula	1%
1032	Pancreatic Fistula	1%
1033	Retinal Hemorrhage	1%
1034	Subclavian Steal Syndrome	1%
1035	Pick Disease of the Brain	1%
1036	Cataplexy	1%
1037	Choroid Hemorrhage	1%
1038	Intestinal Fistula	1%
1039	Melena	1%
1040	Gastroschisis	1%
1041	Enterocutaneous Fistula	1%
1042	Toxoplasmosis, Congenital	1%
1043	Eye Burns	1%
1044	Postpartum Hemorrhage	1%
1045	Salivary Gland Fistula	1%
1046	Malaria, Cerebral	1%
1047	Cystocele	1%
1048	Gingival Hemorrhage	1%
1049	Keloid	1%
1050	Carotid Stenosis	1%
1051	Intracranial Aneurysm	1%
1052	Monosomy	1%
1053	Welander Distal Myopathy	1%
1054	Tetraploidy	1%
1055	Stillbirth	1%
1056	Adams-Stokes Syndrome	1%
1057	Atrioventricular Block	1%
1058	Bundle-Branch Block	1%
1059	Atrial Premature Complexes	1%
1060	Sinoatrial Block	1%
1061	Tachycardia, Paroxysmal	1%
1062	Supraventricular tachycardia	1%
1063	Tachycardia, Ventricular	1%
1064	Tachycardia, Reciprocating	1%
1065	Neurocysticercosis	1%
1066	Intracranial Arteriosclerosis	1%
1067	Cerebral Atherosclerosis	1%
1068	Cerebral Arteriosclerosis	1%
1069	Cerebral Thrombosis	1%
1070	Intracranial Embolism	1%
1071	Intracranial Thrombosis	1%
1072	Wernicke Encephalopathy	0.9%
1073	AIDS Dementia Complex	0.9%
1074	Lyme Neuroborreliosis	0.9%
1075	Viremia	0.8%
1076	Parasitemia	0.8%
1077	Dermatomyositis	0.8%
1078	Cellulitis	0.8%
1079	Corneal Scar	0.8%
1080	Umbilical hernia	0.8%
1081	Muscular Dystrophy, Duchenne	0.8%
1082	Acromegaly	0.8%
1083	Romano-Ward Syndrome	0.8%
1084	Carotid Artery Thrombosis	0.8%
1085	Cerebral Amyloid Angiopathy	0.8%
1086	Sinus Thrombosis, Intracranial	0.8%
1087	Granuloma, Laryngeal	0.7%
1088	Cavernous Sinus Thrombosis	0.7%
1089	Sagittal Sinus Thrombosis	0.7%
1090	Myocardial Reperfusion Injury	0.7%
1091	Urinary Bladder Fistula	0.7%
1092	Corneal Perforation	0.7%
1093	Bacteremia	0.7%
1094	Cell Transformation, Viral	0.7%
1095	Fungemia	0.6%
1096	Tachycardia, Atrioventricular Nodal Reentry	0.6%
1097	Tachycardia, Ectopic Atrial	0.6%
1098	Tachycardia, Ectopic Junctional	0.6%
1099	Sinus Tachycardia	0.6%
1100	Torsades de Pointes	0.6%
1101	Accelerated Idioventricular Rhythm	0.6%
1102	Arteriovenous fistula	0.6%
1103	Galactosemias	0.6%
1104	Urea Cycle Disorders, Inborn	0.6%
1105	Tyrosinemias	0.6%
1106	Nelson Syndrome	0.6%
1107	Fabry Disease	0.6%
1108	Philadelphia Chromosome	0.6%
1109	Prolactinoma	0.6%
1110	Growth Hormone-Secreting Pituitary Adenoma	0.6%
1111	Homocystinuria	0.5%
1112	Rectal Fistula	0.5%
1113	Anal Fistula	0.5%
1114	Leigh Disease	0.5%
1115	Kidney Calculi	0.5%
1116	Ureteral Calculi	0.5%
1117	Endotoxemia	0.5%
1118	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.4%
1119	Zellweger Syndrome	0.4%
1120	Glycogen storage disease type II	0.4%
1121	Candidemia	0.3%
1122	Gaucher Disease	0.3%
1123	Tay-Sachs Disease	0.3%
1124	Niemann-Pick Disease, Type C	0.3%

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