MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Waardenburg Syndrome

(UMLS:C3266898)

Definition:: Rare, autosomal dominant disease with variable penetrance and several known clinical types. Characteristics may include depigmentation of the hair and skin, congenital deafness, heterochromia iridis, medial eyebrow hyperplasia, hypertrophy of the nasal root, and especially dystopia canthorum. The underlying cause may be defective development of the neural crest (neurocristopathy). Waardenburg's syndrome may be closely related to piebaldism. Klein-Waardenburg Syndrome refers to a disorder that also includes upper limb abnormalities.
UMLS ID:: C3266898
MeSH ID:: D014849

Classification:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.938

Synonym(s)

Waardenburg Syndrome

Waardenburg

Waardenburg syndrome

Waardenburg's Syndrome

Waardenburg's syndrome

Waardenburg, types I and II

White forelock syndrome

syndrome waardenburg

van der Hoeve Halbertsona Waardenburg syndrome

10.

waardenburg syndrome

11.

waardenburg's syndrome

12.

waardenburgs syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fluoxetine	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Prune Belly Syndrome	46.7%
2	Beckwith-Wiedemann Syndrome	36.7%
3	Wolf-Hirschhorn Syndrome	36.7%
4	Bloom Syndrome	31.1%
5	Abnormalities, Drug-Induced	31%
6	Situs Inversus	31%
7	Smith-Magenis syndrome	29.7%
8	Cri-du-Chat Syndrome	29.1%
9	Down Syndrome	29.1%
10	Trisomy 21	29.1%
11	CHARGE Syndrome	28.8%
12	Holoprosencephaly	25.6%
13	Ectodermal Dysplasia	24.4%
14	Aplasia Cutis Congenita	24.4%
15	Prader-Willi Syndrome	24.2%
16	Nail-Patella Syndrome	23.3%
17	Mobius Syndrome	23%
18	Eye Abnormalities	22%
19	Cardiovascular Abnormalities	22%
20	Rubinstein-Taybi Syndrome	21.8%
21	Polycystic Kidney Diseases	21%
22	Skin Abnormalities	20.9%
23	Lymphatic Abnormalities	20.9%
24	Congenital Microtia	20.9%
25	Congenital diaphragmatic hernia	20.2%
26	Twins, Conjoined	20%
27	Genetic Diseases, Inborn	18.5%
28	POEMS Syndrome	18.4%
29	Marfan Syndrome	18.1%
30	Primary Ciliary Dyskinesia	18%
31	Anencephaly	17.4%
32	Cockayne Syndrome	17.1%
33	Aicardi's syndrome	16.9%
34	Urogenital Abnormalities	16.4%
35	Smith-Lemli-Opitz Syndrome	15.8%
36	Polycystic Kidney, Autosomal Dominant	15.5%
37	Kartagener Syndrome	14.1%
38	Maxillofacial Abnormalities	14.1%
39	Dural Arteriovenous Fistula	14.1%
40	Dextrocardia	13.9%
41	Anophthalmos	13.6%
42	Anus, Imperforate	13.6%
43	Hydranencephaly	13.6%
44	Microphthalmos	13.6%
45	Neural Tube Defects	13.6%
46	Tethered Cord Syndrome	13.6%
47	Iniencephaly	13.6%
48	Craniorachischisis	13.6%
49	Limb Deformities, Congenital	13.6%
50	Exencephaly	13.6%
51	Septo-Optic Dysplasia	13.6%
52	Craniofacial Abnormalities	13.6%
53	Cortical Dysplasia	13.6%
54	Malformations of Cortical Development	13.6%
55	Anorectal Malformations	13.6%
56	Alstrom Syndrome	13.1%
57	Fetal Diseases	12.2%
58	Xeroderma	12.2%
59	Microcephaly	10.7%
60	Macrocephaly	10.7%
61	Basal Cell Nevus Syndrome	10.5%
62	Williams Syndrome	10.5%
63	Abdominal Cramps	10.3%
64	Amniotic Band Syndrome	10.3%
65	Asphyxia Neonatorum	10.3%
66	Blepharophimosis	10.3%
67	Infant, Premature, Diseases	10.3%
68	Laryngostenosis	10.3%
69	Mouth Abnormalities	10.3%
70	Infantile Colic	10.3%
71	Scimitar Syndrome	10.2%
72	Esophageal Atresia	10.2%
73	Intestinal Atresia	10.2%
74	Horseshoe Kidney	10.2%
75	Pectus excavatum	10.2%
76	Zellweger Syndrome	10.1%
77	Klippel-Feil Syndrome	10.1%
78	Gastroschisis	10.1%
79	Synostosis	10.1%
80	Acrodermatitis	10%
81	Lymphangiectasis, Intestinal	10%
82	Gianotti-Crosti Syndrome	10%
83	Abnormalities, Radiation-Induced	10%
84	Amelia	9.9%
85	Arachnodactyly	9.9%
86	Ectopia Cordis	9.9%
87	Ectromelia	9.9%
88	Hemimelia	9.9%
89	Meningomyelocele	9.9%
90	Phocomelia	9.9%
91	Sirenomelia	9.9%
92	Spina Bifida	9.9%
93	Polydactyly	9.9%
94	Brachydactyly	9.9%
95	Plagiocephaly	9.9%
96	Lower Extremity Deformities, Congenital	9.9%
97	Upper Extremity Deformities, Congenital	9.9%
98	Single umbilical artery	9.9%
99	Craniosynostosis	9.8%
100	Syndactyly	9.8%
101	Brachycephaly	9.8%
102	Fragile X Syndrome	9.7%
103	Porencephaly	9.7%
104	Classical Lissencephalies and Subcortical Band Heterotopias	9.2%
105	Retinal Dysplasia	9.2%
106	Aniridia	9.1%
107	Epidermolysis Bullosa	8.9%
108	Acrocephalosyndactylia	8.7%
109	Noonan Syndrome	8.6%
110	Cystic Fibrosis	8.5%
111	Arthrogryposis	8.3%
112	Choanal Atresia	8.3%
113	Tracheobronchomegaly	8.3%
114	Laryngocele	8.3%
115	Choledochal Cyst	8.2%
116	Hermaphroditism	8.2%
117	Disorders of Sex Development	8.2%
118	Cryptorchidism	8.1%
119	Dermal Sinus	8.1%
120	Spina Bifida Cystica	8.1%
121	Spina Bifida Occulta	8.1%
122	Lissencephaly	8.1%
123	Polymicrogyria	8.1%
124	Pachygyria	8.1%
125	Schizencephaly	8.1%
126	Hypospadias	8.1%
127	Periventricular Nodular Heterotopia	8.1%
128	Central Nervous System Cysts	8.1%
129	Poland Syndrome	8%
130	Dandy-Walker Syndrome	8%
131	Jaw Abnormalities	7.9%
132	Ichthyosis, X-Linked	7.9%
133	Turner Syndrome	7.8%
134	Cleft Palate	7.6%
135	Aortic coarctation	7.4%
136	Cor Triatriatum	7.4%
137	Coronary Vessel Anomalies	7.4%
138	Dental Enamel Hypoplasia	7.4%
139	Patent ductus arteriosus	7.4%
140	Ebstein Anomaly	7.4%
141	Heart Septal Defects	7.4%
142	Hypodontia	7.4%
143	Macrostomia	7.4%
144	Meningocele	7.4%
145	Microstomia	7.4%
146	Tetralogy of Fallot	7.4%
147	Transposition of Great Vessels	7.4%
148	Hypoplastic Left Heart Syndrome	7.4%
149	May-Thurner Syndrome	7.4%
150	Encephalocele	7.4%
151	Craniofacial Dysostosis	7.4%
152	Neoplastic Syndromes, Hereditary	7.3%
153	Wolff-Parkinson-White Syndrome	7.3%
154	Klinefelter Syndrome	7.1%
155	Meconium Aspiration Syndrome	6.9%
156	Laryngomalacia	6.9%
157	Anemia, Neonatal	6.8%
158	Multiple Epiphyseal Dysplasia	6.8%
159	Osteochondrodysplasias	6.8%
160	Pelger-Huet Anomaly	6.8%
161	Persistent Fetal Circulation Syndrome	6.8%
162	Werner Syndrome	6.8%
163	Myasthenic Syndromes, Congenital	6.8%
164	Pectus carinatum	6.8%
165	Bladder Exstrophy	6.7%
166	Epispadias	6.7%
167	Umbilical hernia	6.7%
168	Pseudoxanthoma Elasticum	6.7%
169	Familial Mediterranean Fever	6.7%
170	Multicystic Dysplastic Kidney	6.6%
171	Micrognathism	6.6%
172	Pierre Robin Syndrome	6.6%
173	Charcot-Marie-Tooth Disease	6.5%
174	Antley-Bixler Syndrome Phenotype	6.5%
175	Sjogren-Larsson Syndrome	6.4%
176	Kallmann Syndrome	6.3%
177	Hyperkeratosis, Epidermolytic	6.2%
178	Aortopulmonary Septal Defect	6.1%
179	Double Outlet Right Ventricle	6.1%
180	Endocardial Cushion Defects	6.1%
181	Myocardial bridging	6.1%
182	Aorticopulmonary Septal Defect	6.1%
183	Xeroderma Pigmentosum	6%
184	Long QT Syndrome	6%
185	Platybasia	6%
186	Tricuspid Atresia	6%
187	Arrhythmogenic Right Ventricular Dysplasia	6%
188	Gonadal Dysgenesis	5.9%
189	Bronchomalacia	5.9%
190	Adrenogenital Syndrome	5.9%
191	Tracheomalacia	5.9%
192	Ovotesticular Disorders of Sex Development	5.9%
193	Retrognathia	5.8%
194	Truncus Arteriosus, Persistent	5.4%
195	Goldenhar Syndrome	5.4%
196	Dwarfism	5.4%
197	Hyperandrogenism	5.4%
198	Anemia, Sickle Cell	5.3%
199	Thalassemia	5.3%
200	Neonatal Abstinence Syndrome	5.3%
201	Tuberous Sclerosis	5.3%
202	Muscular Dystrophy, Duchenne	5.2%
203	Prognathism	5.2%
204	Fetal Growth Retardation	5.1%
205	Muscular Dystrophy	5%
206	Osteogenesis Imperfecta	5%
207	Fetal Hypoxia	5%
208	Congenital nystagmus	5%
209	Fetal Alcohol Spectrum Disorders	5%
210	Toxoplasmosis, Congenital	5%
211	Syphilis, Congenital	5%
212	Mandibulofacial Dysostosis	4.9%
213	Rett Syndrome	4.9%
214	Romano-Ward Syndrome	4.9%
215	Refsum Disease	4.9%
216	Albinism	4.6%
217	Paralysis, Obstetric	4.5%
218	Retinopathy of Prematurity	4.5%
219	Amino Acid Metabolism, Inborn Errors	4.4%
220	Carbohydrate Metabolism, Inborn Errors	4.4%
221	Metal Metabolism, Inborn Errors	4.4%
222	Progeria	4.4%
223	Lysosomal Storage Diseases	4.4%
224	Cytochrome-c Oxidase Deficiency	4.4%
225	Peroxisomal Disorders	4.4%
226	Talipes	4.4%
227	Bronchopulmonary Dysplasia	4.4%
228	Autoimmune Lymphoproliferative Syndrome	4.1%
229	Congenital clubfoot	4.1%
230	Vertical Talus	4.1%
231	Congenital Hyperinsulinism	4.1%
232	Chorioamnionitis	4%
233	Angioedemas, Hereditary	4%
234	Mucopolysaccharidosis II	3.9%
235	Sickle Cell Trait	3.9%
236	Wiskott-Aldrich Syndrome	3.8%
237	Neuronal Ceroid-Lipofuscinoses	3.5%
238	Menkes Kinky Hair Syndrome	3.5%
239	Arteriovenous fistula	3.5%
240	Respiratory Distress Syndrome, Newborn	3.4%
241	Cutis Laxa	3.4%
242	Retinitis Pigmentosa	3.4%
243	Pigmentary retinopathy	3.4%
244	Porokeratosis	3.3%
245	Keratoderma, Palmoplantar	3.3%
246	Chronic granulomatous disease	3.3%
247	Myotonic Dystrophy	3.3%
248	Welander Distal Myopathy	3.3%
249	Alkaptonuria	3.3%
250	Glycogen Storage Disease	3.3%
251	Hypophosphatasia	3.3%
252	Propionic acidemia	3.3%
253	Dihydropyrimidine Dehydrogenase Deficiency	3.3%
254	Cystinosis	3.3%
255	Acute Chest Syndrome	2.8%
256	Amyloid Neuropathies, Familial	2.8%
257	Ophthalmia Neonatorum	2.8%
258	Galactosemias	2.8%
259	Urea Cycle Disorders, Inborn	2.8%
260	Tyrosinemias	2.8%
261	Adrenoleukodystrophy	2.7%
262	Duane Retraction Syndrome	2.7%
263	Hepatolenticular Degeneration	2.7%
264	Porphyrias, Hepatic	2.7%
265	Glycogen Storage Disease Type I	2.7%
266	Glycogen Storage Disease Type V	2.7%
267	Hydrops Fetalis	2.7%
268	Mucopolysaccharidosis III	2.7%
269	Glycogen storage disease type II	2.7%
270	Peutz-Jeghers Syndrome	2.7%
271	Myotonia Congenita	2.6%
272	Thrombasthenia	2.6%
273	Antithrombin III Deficiency	2.6%
274	Protein C Deficiency	2.6%
275	Brain Diseases, Metabolic, Inborn	2.6%
276	Fabry Disease	2.6%
277	Afibrinogenemia	2.6%
278	Dystonia Musculorum Deformans	2.6%
279	Factor VII Deficiency	2.6%
280	Factor X Deficiency	2.6%
281	Factor XII Deficiency	2.6%
282	Hemophilia A	2.6%
283	Leukomalacia, Periventricular	2.6%
284	Activated Protein C Resistance	2.6%
285	Factor II deficiency	2.6%
286	Factor VIII Deficiency	2.6%
287	Factor V deficiency	2.6%
288	Factor XI Deficiency	2.6%
289	Hypoprothrombinemias	2.6%
290	Fanconi Anemia	2.6%
291	Nesidioblastosis	2.6%
292	Lafora Disease	2.6%
293	Unverricht-Lundborg Syndrome	2.6%
294	Anemia, Diamond-Blackfan	2.6%
295	Denys-Drash Syndrome	2.6%
296	Ataxia Telangiectasia	2.5%
297	Hyaline Membrane Disease	2.5%
298	Optic Atrophy, Hereditary, Leber	2.4%
299	Hypolipoproteinemias	2.4%
300	Papillon-Lefevre Disease	2.4%
301	Hyperlipidemia, Familial Combined	2.4%
302	Hyperlipoproteinemia Type III	2.4%
303	Hyperphosphaturia	2.4%
304	Canavan Disease	2.3%
305	Alexander Disease	2.3%
306	Multiple Endocrine Neoplasia	2.3%
307	Homocystinuria	2.2%
308	Congenital Hypothyroidism	2.2%
309	Dermatitis, Atopic	2.2%
310	Leigh Disease	2.2%
311	Gaucher Disease	2.1%
312	Hypoalphalipoproteinemias	2%
313	Carbamoyl-Phosphate Synthase I Deficiency Disease	2%
314	Familial Periodic Paralysis	2%
315	Lactose Intolerance	2%
316	Variegate Porphyria	2%
317	Acute intermittent porphyria	2%
318	Porphyria Cutanea Tarda	2%
319	Hyperhomocysteinemia	2%
320	Tay-Sachs Disease	1.9%
321	Renal Aminoacidurias	1.9%
322	Fanconi Syndrome	1.9%
323	Pseudohypoaldosteronism	1.9%
324	Liddle Syndrome	1.9%
325	Hyperlipoproteinemia Type IV	1.9%
326	Hyperlipoproteinemia Type V	1.9%
327	Kernicterus	1.9%
328	Behcet Syndrome	1.9%
329	Niemann-Pick Disease, Type C	1.8%
330	Gout	1.7%
331	Multiple Endocrine Neoplasia Type 1	1.6%
332	Pseudohypoparathyroidism	1.6%
333	Huntington Disease	1.6%
334	Friedreich Ataxia	1.6%
335	Hypokalemic periodic paralysis	1.6%
336	Renal tubular acidosis	1.6%
337	Cystinuria	1.6%
338	Nephroblastoma	1.5%
339	Arthritis, Gouty	1.4%
340	Adenomatous Polyposis Coli	1.3%
341	Familial Hypophosphatemic Rickets	1.2%
342	Glycosuria, Renal	1.2%
343	MELAS Syndrome	1%

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