MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Prader-Willi Syndrome

(UMLS:C0032897)

Definition:: An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229)
UMLS ID:: C0032897
MeSH ID:: D011218

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.597.606.360.690

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.730|C16.131.260.700|C16.320.180.700

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.726.500.740

Synonym(s)

Prader-Willi Syndrome

H2O syndrome

OBESITY-CRYPTORCHIDISM-DWARFISM-SUBNORMAL MENTALITY SYNDROME

PRADER WILLI SYNDROME

PRADER-WILLI SYNDROME

PWS

Prader Labhart Willi syndrome

Prader Willi Syndrome

Prader Willi syndrome

10.

Prader-Labhart-Willi (PLW) syndrome (PLWS)

11.

Prader-Labhart-Willi Syndrome

12.

Prader-Labhart-Willi-Fanconi syndrome

13.

Prader-Willi

14.

Prader-Willi syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Dexamethasone	FAERS: 1		US FAERS
2	Finasteride	FAERS: 1		US FAERS
3	Metformin	FAERS: 1		US FAERS
4	Mycophenolic Acid	FAERS: 1		US FAERS
5	Paroxetine	FAERS: 1		US FAERS
6	Topiramate	FAERS: 1		US FAERS
7	Risperidone		20158635	CTD
8	propiomazine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Cri-du-Chat Syndrome	56.4%
2	Down Syndrome	56.4%
3	Trisomy 21	56.4%
4	Beckwith-Wiedemann Syndrome	51.2%
5	Wolf-Hirschhorn Syndrome	51.2%
6	Rubinstein-Taybi Syndrome	47.9%
7	Smith-Magenis syndrome	47.8%
8	Holoprosencephaly	46.4%
9	Williams Syndrome	40.1%
10	Fragile X Syndrome	36.6%
11	Aicardi's syndrome	32.2%
12	CHARGE Syndrome	30.8%
13	Ectodermal Dysplasia	30.5%
14	Aplasia Cutis Congenita	30.5%
15	Nail-Patella Syndrome	27.6%
16	Kartagener Syndrome	27.2%
17	Cockayne Syndrome	27%
18	Marfan Syndrome	26.5%
19	Alstrom Syndrome	25.8%
20	Prune Belly Syndrome	24.2%
21	Waardenburg Syndrome	24.2%
22	Mobius Syndrome	24.1%
23	Smith-Lemli-Opitz Syndrome	23.7%
24	Abnormalities, Drug-Induced	23.3%
25	Situs Inversus	23.3%
26	Polycystic Kidney Diseases	23.3%
27	Bloom Syndrome	22.2%
28	Anencephaly	21.4%
29	Rett Syndrome	21.4%
30	Ichthyosis, X-Linked	21.1%
31	Eye Abnormalities	20.6%
32	Cardiovascular Abnormalities	20.6%
33	Primary Ciliary Dyskinesia	20.3%
34	Skin Abnormalities	20.2%
35	Lymphatic Abnormalities	20.2%
36	Congenital Microtia	20.2%
37	Mucopolysaccharidosis II	20%
38	Dural Arteriovenous Fistula	19.9%
39	Congenital diaphragmatic hernia	19.9%
40	Menkes Kinky Hair Syndrome	19.5%
41	Turner Syndrome	19.1%
42	Klinefelter Syndrome	18.2%
43	Cystic Fibrosis	18.2%
44	Urogenital Abnormalities	18.1%
45	Maxillofacial Abnormalities	18.1%
46	Dextrocardia	17.9%
47	Zellweger Syndrome	17.8%
48	Polycystic Kidney, Autosomal Dominant	17.3%
49	Adrenoleukodystrophy	17.1%
50	Xeroderma	17%
51	POEMS Syndrome	16.8%
52	Classical Lissencephalies and Subcortical Band Heterotopias	16.8%
53	Refsum Disease	16.2%
54	Retinal Dysplasia	16.2%
55	Tuberous Sclerosis	16.2%
56	Aniridia	16.1%
57	Sjogren-Larsson Syndrome	16.1%
58	Epidermolysis Bullosa	15.9%
59	Hydranencephaly	15.7%
60	Neural Tube Defects	15.7%
61	Werner Syndrome	15.7%
62	Tethered Cord Syndrome	15.7%
63	Iniencephaly	15.7%
64	Craniorachischisis	15.7%
65	Exencephaly	15.7%
66	Septo-Optic Dysplasia	15.7%
67	Cortical Dysplasia	15.7%
68	Myasthenic Syndromes, Congenital	15.7%
69	Malformations of Cortical Development	15.7%
70	Albinism	15.7%
71	Twins, Conjoined	15.4%
72	Muscular Dystrophy, Duchenne	15.1%
73	Acrocephalosyndactylia	15%
74	Basal Cell Nevus Syndrome	15%
75	Scimitar Syndrome	15%
76	Fetal Diseases	14.7%
77	Neoplastic Syndromes, Hereditary	14.7%
78	Microcephaly	14.7%
79	Macrocephaly	14.7%
80	Anemia, Sickle Cell	14.6%
81	Thalassemia	14.6%
82	Multiple Epiphyseal Dysplasia	14.3%
83	Osteochondrodysplasias	14.3%
84	Pelger-Huet Anomaly	14.3%
85	Kallmann Syndrome	14.2%
86	Abnormalities, Radiation-Induced	13.9%
87	Charcot-Marie-Tooth Disease	13.9%
88	Craniosynostosis	13.7%
89	Syndactyly	13.7%
90	Brachycephaly	13.7%
91	Dandy-Walker Syndrome	13.6%
92	Hepatolenticular Degeneration	13.4%
93	Porencephaly	13.4%
94	Anophthalmos	13.3%
95	Anus, Imperforate	13.3%
96	Microphthalmos	13.3%
97	Limb Deformities, Congenital	13.3%
98	Craniofacial Abnormalities	13.3%
99	Anorectal Malformations	13.3%
100	Pseudoxanthoma Elasticum	13.3%
101	Central Nervous System Cysts	13.3%
102	Muscular Dystrophy	13.3%
103	Prader-Willi Syndrome	13.2%
104	Xeroderma Pigmentosum	13.1%
105	Dwarfism	12.8%
106	Neuronal Ceroid-Lipofuscinoses	12.7%
107	Myotonic Dystrophy	12.7%
108	Cleft Palate	12.7%
109	Noonan Syndrome	12.7%
110	Osteogenesis Imperfecta	12.4%
111	Antley-Bixler Syndrome Phenotype	12.4%
112	Amyloid Neuropathies, Familial	12.2%
113	Hyperkeratosis, Epidermolytic	12.2%
114	Meconium Aspiration Syndrome	12.2%
115	Obesity, Abdominal	12.2%
116	Ataxia Telangiectasia	12%
117	Wiskott-Aldrich Syndrome	12%
118	Fabry Disease	11.9%
119	Blepharophimosis	11.8%
120	Laryngostenosis	11.8%
121	Mouth Abnormalities	11.8%
122	Esophageal Atresia	11.7%
123	Intestinal Atresia	11.7%
124	Horseshoe Kidney	11.7%
125	Pectus excavatum	11.7%
126	Klippel-Feil Syndrome	11.6%
127	Gastroschisis	11.6%
128	Synostosis	11.6%
129	Jaw Abnormalities	11.6%
130	Acrodermatitis	11.6%
131	Lymphangiectasis, Intestinal	11.6%
132	Gianotti-Crosti Syndrome	11.6%
133	Genetic Diseases, Inborn	11.4%
134	Poland Syndrome	11.3%
135	Meningomyelocele	11.3%
136	Spina Bifida	11.3%
137	Autoimmune Lymphoproliferative Syndrome	11.2%
138	Galactosemias	11.1%
139	Urea Cycle Disorders, Inborn	11.1%
140	Tyrosinemias	11.1%
141	Glycogen storage disease type II	11.1%
142	Canavan Disease	11.1%
143	Alexander Disease	11.1%
144	Angioedemas, Hereditary	11%
145	Familial Mediterranean Fever	11%
146	Amino Acid Metabolism, Inborn Errors	10.8%
147	Carbohydrate Metabolism, Inborn Errors	10.8%
148	Metal Metabolism, Inborn Errors	10.8%
149	Progeria	10.8%
150	Lysosomal Storage Diseases	10.8%
151	Cytochrome-c Oxidase Deficiency	10.8%
152	Peroxisomal Disorders	10.8%
153	Sickle Cell Trait	10.8%
154	Pediatric Obesity	10.8%
155	Arthrogryposis	10.5%
156	Choanal Atresia	10.5%
157	Tracheobronchomegaly	10.5%
158	Laryngocele	10.5%
159	Choledochal Cyst	10.4%
160	Hermaphroditism	10.4%
161	Disorders of Sex Development	10.4%
162	Cryptorchidism	10.4%
163	Hypospadias	10.4%
164	Brain Diseases, Metabolic, Inborn	10.3%
165	Leigh Disease	10.1%
166	Abdominal Cramps	10%
167	Amniotic Band Syndrome	10%
168	Asphyxia Neonatorum	10%
169	Infant, Premature, Diseases	10%
170	Infantile Colic	10%
171	Optic Atrophy, Hereditary, Leber	9.9%
172	Meningocele	9.9%
173	Encephalocele	9.9%
174	Amelia	9.9%
175	Arachnodactyly	9.9%
176	Ectopia Cordis	9.9%
177	Ectromelia	9.9%
178	Hemimelia	9.9%
179	Phocomelia	9.9%
180	Sirenomelia	9.9%
181	Polydactyly	9.9%
182	Brachydactyly	9.9%
183	Plagiocephaly	9.9%
184	Lower Extremity Deformities, Congenital	9.9%
185	Upper Extremity Deformities, Congenital	9.9%
186	Single umbilical artery	9.9%
187	Dystonia Musculorum Deformans	9.9%
188	Micrognathism	9.8%
189	Pierre Robin Syndrome	9.8%
190	Hyperphosphaturia	9.7%
191	Wasting Syndrome	9.6%
192	Laryngomalacia	9.5%
193	Gaucher Disease	9.5%
194	Pectus carinatum	9.4%
195	Homocystinuria	9.4%
196	Bladder Exstrophy	9.3%
197	Epispadias	9.3%
198	Multicystic Dysplastic Kidney	9.3%
199	Myotonia Congenita	9.2%
200	Lafora Disease	9.2%
201	Unverricht-Lundborg Syndrome	9.2%
202	Dermal Sinus	9.1%
203	Spina Bifida Cystica	9.1%
204	Spina Bifida Occulta	9.1%
205	Lissencephaly	9.1%
206	Polymicrogyria	9.1%
207	Pachygyria	9.1%
208	Schizencephaly	9.1%
209	Carbamoyl-Phosphate Synthase I Deficiency Disease	9.1%
210	Periventricular Nodular Heterotopia	9.1%
211	Mucopolysaccharidosis III	9.1%
212	Retrognathia	9%
213	Acute Chest Syndrome	9%
214	Welander Distal Myopathy	8.8%
215	Confusion	8.7%
216	Lethargy	8.7%
217	Memory Disorders	8.7%
218	Perceptual Disorders	8.7%
219	Psychomotor Disorders	8.7%
220	Anhedonia	8.7%
221	Disorientation	8.7%
222	Memory Loss	8.7%
223	Hemisensory Neglect	8.7%
224	Hyperandrogenism	8.7%
225	Aortic coarctation	8.6%
226	Cor Triatriatum	8.6%
227	Coronary Vessel Anomalies	8.6%
228	Dental Enamel Hypoplasia	8.6%
229	Patent ductus arteriosus	8.6%
230	Ebstein Anomaly	8.6%
231	Heart Septal Defects	8.6%
232	Hypodontia	8.6%
233	Macrostomia	8.6%
234	Microstomia	8.6%
235	Tetralogy of Fallot	8.6%
236	Transposition of Great Vessels	8.6%
237	Hypoplastic Left Heart Syndrome	8.6%
238	May-Thurner Syndrome	8.6%
239	Hyperhomocysteinemia	8.6%
240	Craniofacial Dysostosis	8.6%
241	Duane Retraction Syndrome	8.6%
242	Anemia, Neonatal	8.6%
243	Persistent Fetal Circulation Syndrome	8.6%
244	Wolff-Parkinson-White Syndrome	8.6%
245	Porphyrias, Hepatic	8.5%
246	Umbilical hernia	8.5%
247	Tay-Sachs Disease	8.5%
248	Fanconi Anemia	8.4%
249	Prognathism	8.4%
250	Child Nutrition Disorders	8.3%
251	Cutis Laxa	8.3%
252	Hypervitaminosis A	8.3%
253	Infant Nutrition Disorders	8.3%
254	Malnutrition	8.3%
255	Retinitis Pigmentosa	8.3%
256	Congenital nystagmus	8.3%
257	Pigmentary retinopathy	8.3%
258	Porokeratosis	8.3%
259	Keratoderma, Palmoplantar	8.3%
260	Chronic granulomatous disease	8.2%
261	Niemann-Pick Disease, Type C	8.2%
262	Congenital Hyperinsulinism	8.1%
263	Toxoplasmosis, Congenital	8%
264	Alkaptonuria	7.9%
265	Glycogen Storage Disease	7.9%
266	Hypophosphatasia	7.9%
267	Propionic acidemia	7.9%
268	Dihydropyrimidine Dehydrogenase Deficiency	7.9%
269	Cystinosis	7.9%
270	Consciousness Disorders	7.8%
271	Depressed Level of Consciousness	7.8%
272	Huntington Disease	7.8%
273	Hypolipoproteinemias	7.8%
274	Catatonia	7.7%
275	Long QT Syndrome	7.7%
276	Platybasia	7.7%
277	Tricuspid Atresia	7.7%
278	Arrhythmogenic Right Ventricular Dysplasia	7.7%
279	Friedreich Ataxia	7.7%
280	Gonadal Dysgenesis	7.7%
281	Bronchomalacia	7.7%
282	Adrenogenital Syndrome	7.7%
283	Tracheomalacia	7.7%
284	Ovotesticular Disorders of Sex Development	7.7%
285	Neonatal Abstinence Syndrome	7.6%
286	Pseudohypoparathyroidism	7.6%
287	Hyperlipidemia, Familial Combined	7.5%
288	Akathisia	7.5%
289	Restlessness	7.5%
290	Psychomotor Agitation	7.5%
291	Fetal Growth Retardation	7.5%
292	Asterixis	7.5%
293	Ballismus	7.5%
294	Fetal Hypoxia	7.5%
295	Fetal Alcohol Spectrum Disorders	7.5%
296	Hyperlipoproteinemia Type III	7.4%
297	Syphilis, Congenital	7.4%
298	Familial Periodic Paralysis	7.4%
299	Peutz-Jeghers Syndrome	7.3%
300	Thrombasthenia	7.3%
301	Antithrombin III Deficiency	7.3%
302	Protein C Deficiency	7.3%
303	Afibrinogenemia	7.3%
304	Factor VII Deficiency	7.3%
305	Factor X Deficiency	7.3%
306	Factor XII Deficiency	7.3%
307	Hemophilia A	7.3%
308	Activated Protein C Resistance	7.3%
309	Factor II deficiency	7.3%
310	Factor VIII Deficiency	7.3%
311	Factor V deficiency	7.3%
312	Factor XI Deficiency	7.3%
313	Hypoprothrombinemias	7.3%
314	Lactose Intolerance	7.3%
315	Anemia, Diamond-Blackfan	7.2%
316	Decerebrate State	7.1%
317	Hemiparesis	7.1%
318	Meningism	7.1%
319	Paresis	7.1%
320	Seizures	7.1%
321	Sensation Disorders	7.1%
322	Complex partial seizures	7.1%
323	Monoparesis	7.1%
324	Neurogenic Inflammation	7.1%
325	Gait Disorders, Neurologic	7.1%
326	Neuromuscular Manifestations	7.1%
327	Aortopulmonary Septal Defect	7.1%
328	Double Outlet Right Ventricle	7.1%
329	Endocardial Cushion Defects	7.1%
330	Myocardial bridging	7.1%
331	Aorticopulmonary Septal Defect	7.1%
332	Hyperlipoproteinemia Type IV	7%
333	Hyperlipoproteinemia Type V	7%
334	Familial Hypophosphatemic Rickets	7%
335	Alexia	6.8%
336	Dyslexia	6.8%
337	Multiple Endocrine Neoplasia	6.8%
338	Hydrops Fetalis	6.7%
339	Congenital Hypothyroidism	6.6%
340	Chorioamnionitis	6.6%
341	Dermatitis, Atopic	6.6%
342	Language Disorders	6.5%
343	Glycogen Storage Disease Type I	6.5%
344	Glycogen Storage Disease Type V	6.5%
345	Pupil Disorders	6.4%
346	Truncus Arteriosus, Persistent	6.4%
347	Goldenhar Syndrome	6.4%
348	Gait Apraxia	6.3%
349	Mandibulofacial Dysostosis	6.3%
350	Romano-Ward Syndrome	6.3%
351	Hypoalphalipoproteinemias	6.3%
352	Alice in Wonderland Syndrome	6.3%
353	Vertigo	6.2%
354	Variegate Porphyria	6.2%
355	Acute intermittent porphyria	6.2%
356	Porphyria Cutanea Tarda	6.2%
357	Renal tubular acidosis	6.2%
358	Denys-Drash Syndrome	6.2%
359	Renal Aminoacidurias	6.1%
360	Fanconi Syndrome	6.1%
361	Pseudohypoaldosteronism	6.1%
362	Liddle Syndrome	6.1%
363	Papillon-Lefevre Disease	6.1%
364	Behcet Syndrome	6%
365	Leukomalacia, Periventricular	5.8%
366	Hypokalemic periodic paralysis	5.8%
367	MELAS Syndrome	5.8%
368	Agnosia	5.7%
369	Apraxias	5.7%
370	Hallucinations	5.7%
371	Visual Agnosia	5.7%
372	Anosognosia	5.7%
373	Wernicke-Korsakoff Syndrome	5.7%
374	Talipes	5.7%
375	Paralysis, Obstetric	5.7%
376	Retinopathy of Prematurity	5.7%
377	Deformity	5.7%
378	Voice Disorders	5.6%
379	Voice Disturbance	5.6%
380	Bronchopulmonary Dysplasia	5.6%
381	Gout	5.6%
382	Subacute Combined Degeneration	5.5%
383	Nesidioblastosis	5.5%
384	Gait Ataxia	5.4%
385	Congenital clubfoot	5.4%
386	Vertical Talus	5.4%
387	Ophthalmia Neonatorum	5.4%
388	Ophthalmoplegic Migraine	5.3%
389	Arteriovenous fistula	5.2%
390	Amnesia	5.1%
391	Delirium	5.1%
392	Dissociative Amnesia	5.1%
393	Global Amnesia	5.1%
394	Kernicterus	5.1%
395	Glycosuria, Renal	5.1%
396	Cranial nerve diseases	5.1%
397	Demyelinating Diseases	5.1%
398	Demyelination	5.1%
399	Metabolic Diseases	5.1%
400	Neuromuscular Diseases	5.1%
401	Chronobiology Disorders	5.1%
402	Persistent Vegetative State	5.1%
403	Nephroblastoma	5%
404	Respiratory Distress Syndrome, Newborn	5%
405	Cystinuria	5%
406	Reflex, Abnormal	5%
407	Hyporeflexia	5%
408	Hyperreflexia	5%
409	Deficiency Diseases	4.9%
410	Starvation	4.9%
411	Refeeding Syndrome	4.9%
412	Multiple Endocrine Neoplasia Type 1	4.9%
413	Agraphia	4.9%
414	Anomia	4.9%
415	Cluttering	4.9%
416	Language Development Disorders	4.9%
417	Speech Disorders	4.9%
418	Syncope	4.9%
419	Stupor	4.9%
420	Dysgraphia	4.9%
421	Presyncope	4.9%
422	Dyslalia	4.9%
423	Stiff-Person Syndrome	4.9%
424	Dyskinesia, Drug-Induced	4.8%
425	Brain Death	4.8%
426	Coma, Post-Head Injury	4.8%
427	Motor Neuron Disease	4.8%
428	Multiple System Atrophy	4.8%
429	Auditory Perceptual Disorders	4.8%
430	Restless Legs Syndrome	4.7%
431	Adenomatous Polyposis Coli	4.6%
432	Amyotrophic Lateral Sclerosis	4.6%
433	Arthritis, Gouty	4.6%
434	Phantom pain	4.6%
435	Phantom Limb Pain	4.6%
436	Chorea	4.5%
437	Tetany	4.5%
438	Trauma, Nervous System	4.5%
439	Polyradiculoneuropathy	4.5%
440	Polyradiculoneuritis	4.5%
441	Ophthalmoplegia	4.4%
442	External Ophthalmoplegia	4.4%
443	Nervous System Neoplasms	4.4%
444	Neurotoxicity Syndromes	4.4%
445	Amnesia, Transient Global	4.4%
446	Progressive supranuclear palsy	4.4%
447	Ocular Motility Disorders	4.3%
448	Cyclophoria	4.3%
449	Dyscalculia	4.3%
450	Gerstmann Syndrome	4.3%
451	Prosopagnosia	4.3%
452	Apraxia, Ideomotor	4.3%
453	Charles Bonnet Syndrome	4.3%
454	Alien Hand Syndrome	4.3%
455	Anosmia	4.2%
456	Ataxia	4.2%
457	Athetosis	4.2%
458	Catalepsy	4.2%
459	Dystonia	4.2%
460	Hemiplegia	4.2%
461	Locked-In Syndrome	4.2%
462	Muscle Hypertonia	4.2%
463	Muscle hypotonia	4.2%
464	Myoclonus	4.2%
465	Myotonia	4.2%
466	Paraplegia	4.2%
467	Pseudobulbar Palsy	4.2%
468	Quadriplegia	4.2%
469	Spasm	4.2%
470	Spastic Paraplegia	4.2%
471	Status Epilepticus	4.2%
472	Taste Disorders	4.2%
473	Tremor	4.2%
474	Monoplegia	4.2%
475	Hypokinesia	4.2%
476	Paraparesis	4.2%
477	Bradykinesia	4.2%
478	Waxy flexibility	4.2%
479	Action Tremor	4.2%
480	Resting Tremor	4.2%
481	Dysosmia	4.2%
482	Quadriparesis	4.2%
483	Olfaction Disorders	4.2%
484	Myokymia	4.2%
485	Somatosensory Disorders	4.2%
486	Hyperkinesia	4.2%
487	Intention tremor	4.2%
488	Myelinolysis, Central Pontine	4.1%
489	Opsoclonus-Myoclonus Syndrome	4.1%
490	Aphasia	4.1%
491	Articulation Disorders	4.1%
492	Echolalia	4.1%
493	Stuttering	4.1%
494	Dysphasia	4.1%
495	Horner Syndrome	4%
496	Vocal Cord Paralysis	4%
497	Cerebrospinal Fluid Otorrhea	4%
498	Cerebrospinal Fluid Rhinorrhea	4%
499	HIV Wasting Syndrome	3.9%
500	Sleep Wake Disorders	3.9%
501	Brain Diseases, Metabolic	3.8%
502	Encephalomyelitis	3.8%
503	Prion Diseases	3.8%
504	Autonomic Dysreflexia	3.8%
505	Complex Regional Pain Syndromes	3.8%
506	Retrograde amnesia	3.8%
507	Amnesia, Anterograde	3.8%
508	Vision Disorders	3.8%
509	Metamorphopsia	3.8%
510	Visual Impairment	3.8%
511	Anisocoria	3.7%
512	Facial paralysis	3.7%
513	Muscle Cramp	3.7%
514	Tonic Pupil	3.7%
515	Facial Paresis	3.7%
516	Dysacusis	3.7%
517	Spinal Muscular Atrophy	3.7%
518	Progressive Muscular Atrophy	3.7%
519	Hyaline Membrane Disease	3.7%
520	Muscular Atrophy	3.7%
521	Respiratory Paralysis	3.7%
522	Meningoencephalitis	3.6%
523	Dysarthria	3.6%
524	Mutism	3.6%
525	Selective Mutism	3.6%
526	Alcohol Withdrawal Seizures	3.6%
527	Rickets	3.6%
528	Parkinson Disease	3.5%
529	Lewy Body Disease	3.5%
530	Guillain-Barre Syndrome	3.4%
531	Spinal Cord Injuries	3.4%
532	Peripheral Nerve Injuries	3.4%
533	Muscle Weakness	3.3%
534	Myasthenia Gravis	3.3%
535	Lambert-Eaton Myasthenic Syndrome	3.3%
536	Marchiafava-Bignami Disease	3.3%
537	Amblyopia	3.3%
538	Aphonia	3.3%
539	Pneumocephalus	3.3%
540	Poliomyelitis	3.3%
541	Dysphonia	3.3%
542	Myelitis, Transverse	3.3%
543	Kwashiorkor	3.3%
544	Magnesium Deficiency	3.3%
545	Potassium Deficiency	3.3%
546	Protein Deficiency	3.3%
547	Avitaminosis	3.3%
548	Cerebellar Ataxia	3.3%
549	Torticollis	3.3%
550	Alexia, Pure	3.2%
551	Leukoencephalitis, Acute Hemorrhagic	3.2%
552	Striatonigral Degeneration	3.1%
553	Miller Fisher Syndrome	3.1%
554	Chronic Fatigue Syndrome	3.1%
555	Tardive Dyskinesia	3%
556	Sleep Disorders, Circadian Rhythm	3%
557	Neuromyelitis Optica	3%
558	Botulism	3%
559	Mitochondrial Encephalomyopathies	3%
560	Epidural Abscess	2.9%
561	Olfactory Nerve Injuries	2.9%
562	Neuroleptic Malignant Syndrome	2.9%
563	Causalgia	2.9%
564	MPTP Poisoning	2.8%
565	Hypercalcemia	2.8%
566	Hypocalcemia	2.8%
567	Milk-Alkali Syndrome	2.8%
568	Myelitis	2.8%
569	Progressive bulbar palsy	2.8%
570	Bulbar palsy	2.8%
571	Dysgeusia	2.8%
572	Formication	2.8%
573	Hyperalgesia	2.8%
574	Hyperesthesia	2.8%
575	Hypesthesia	2.8%
576	Numbness	2.8%
577	Paresthesia	2.8%
578	Paraparesis, Spastic	2.8%
579	Trismus	2.8%
580	Epilepsia Partialis Continua	2.8%
581	Hypogeusia	2.8%
582	Brown-Sequard Syndrome	2.8%
583	Lockjaw	2.8%
584	Allodynia	2.8%
585	Ageusia	2.8%
586	Shy-Drager Syndrome	2.8%
587	Acid-Base Imbalance	2.8%
588	Brain Diseases	2.8%
589	Calcium Metabolism Disorders	2.8%
590	Iron Metabolism Disorders	2.8%
591	Dysautonomia	2.8%
592	Meningitis	2.8%
593	Movement Disorders	2.8%
594	Pachymeningitis	2.8%
595	Phosphorus Metabolism Disorders	2.8%
596	Spinal Cord Diseases	2.8%
597	Water-Electrolyte Imbalance	2.8%
598	Vagus Nerve Disorder	2.8%
599	Lipid Metabolism Disorders	2.8%
600	Glossopharyngeal Neuralgia	2.8%
601	Abducens Nerve Diseases	2.8%
602	Mitochondrial Diseases	2.8%
603	Heavy Metal Poisoning, Nervous System	2.8%
604	Neuromuscular Junction Diseases	2.8%
605	Tauopathies	2.8%
606	Glucose Metabolism Disorders	2.8%
607	Trochlear Nerve Diseases	2.8%
608	Peripheral Nervous System Diseases	2.8%
609	Wernicke Encephalopathy	2.7%
610	Encephalomyelitis, Acute Disseminated	2.7%
611	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.7%
612	Hoarseness	2.7%
613	Akathisia, Drug-Induced	2.7%
614	Leukoencephalopathy, Progressive Multifocal	2.7%
615	Osteomalacia	2.7%
616	Facial Nerve Injuries	2.6%
617	Kearns-Sayre syndrome	2.6%
618	Mitochondrial Myopathies	2.5%
619	Lipodystrophy	2.5%
620	Brain Injuries	2.5%
621	Diplopia	2.5%
622	Muscle Rigidity	2.5%
623	Muscle Spasticity	2.5%
624	Scotoma	2.5%
625	Photophobia	2.5%
626	Cogwheel Rigidity	2.5%
627	Hemifacial Spasm	2.5%
628	Amaurosis	2.5%
629	Blindness	2.5%
630	Nuchal Rigidity	2.5%
631	Brain Neoplasms	2.5%
632	Multiple Sclerosis	2.5%
633	Spinal Cord Neoplasms	2.5%
634	Hemianopsia	2.5%
635	Hyperacusis	2.5%
636	Tinnitus	2.5%
637	Phonophobia	2.5%
638	Hearing Loss	2.5%
639	Ascorbic Acid Deficiency	2.5%
640	Vitamin A Deficiency	2.5%
641	Vitamin D Deficiency	2.5%
642	Vitamin E Deficiency	2.5%
643	Marasmus	2.5%
644	Central Nervous System Infection	2.5%
645	Myopathy	2.5%
646	Optic Neuropathy	2.5%
647	Sarcopenia	2.4%
648	Facial Nerve Diseases	2.4%
649	Craniocerebral Trauma	2.4%
650	Osteopenia	2.4%
651	Parasomnia	2.4%
652	Dyssomnias	2.4%
653	Vestibulocochlear Nerve Diseases	2.4%
654	Central Nervous System Neoplasms	2.4%
655	Myasthenia Gravis, Autoimmune, Experimental	2.4%
656	Sweating, Gustatory	2.4%
657	Auriculotemporal Syndrome	2.4%
658	Reflex Sympathetic Dystrophy	2.3%
659	Subdural Effusion	2.3%
660	Parkinsonian Disorders	2.3%
661	Nocturnal Myoclonus Syndrome	2.3%
662	Lupus Vasculitis, Central Nervous System	2.3%
663	Vasculitis, Central Nervous System	2.3%
664	Jet Lag Syndrome	2.3%
665	Limbic Encephalitis	2.3%
666	Brain Abscess	2.2%
667	Color blindness	2.2%
668	Epilepsy, Post-Traumatic	2.2%
669	Paraneoplastic Encephalomyelitis	2.1%
670	Uveomeningoencephalitic Syndrome	2.1%
671	Scrapie	2.1%
672	Sturge-Weber Syndrome	2.1%
673	Central Cord Syndrome	2.1%
674	Alcohol-Induced Disorders, Nervous System	2.1%
675	Presenile dementia	2.1%
676	Senile dementia	2.1%
677	Reye Syndrome	2.1%
678	Meningitis, Bacterial	2.1%
679	Meningitis, Fungal	2.1%
680	Hepatic Encephalopathy	2%
681	Acrodynia	2%
682	Folic Acid Deficiency	2%
683	Pellagra	2%
684	Thiamine Deficiency	2%
685	Vitamin B 12 Deficiency	2%
686	Vitamin B 6 Deficiency	2%
687	Pyridoxine Deficiency	2%
688	Renal Osteodystrophy	2%
689	Renal rickets	2%
690	Dementia, Vascular	2%
691	Brain Hemorrhage, Traumatic	2%
692	Meige Syndrome	1.9%
693	Brachial Plexus Neuritis	1.9%
694	Neuralgic Amyotrophy	1.9%
695	Cerebral Ventriculitis	1.9%
696	Vitamin K Deficiency	1.8%
697	Beriberi	1.8%
698	Amaurosis Fugax	1.8%
699	Blindness, Cortical	1.8%
700	Deafness	1.8%
701	Hearing Loss, Sudden	1.8%
702	Hearing Loss, Bilateral	1.8%
703	Hearing Loss, High-Frequency	1.8%
704	Hearing Loss, Mixed Conductive-Sensorineural	1.8%
705	Hearing Loss, Unilateral	1.8%
706	Complete Hearing Loss	1.8%
707	Deaf Mutism	1.8%
708	Paraneoplastic Cerebellar Degeneration	1.8%
709	Neuritis, Autoimmune, Experimental	1.8%
710	Frontotemporal dementia	1.8%
711	Cerebellar Neoplasms	1.8%
712	Carotid Artery Injuries	1.8%
713	Acidosis	1.6%
714	Akinetic Mutism	1.6%
715	Alkalosis	1.6%
716	Amyloidosis	1.6%
717	Anoxic Encephalopathy	1.6%
718	Arachnoiditis	1.6%
719	Basal Ganglia Diseases	1.6%
720	Brain Damage, Chronic	1.6%
721	Calcinosis	1.6%
722	Cerebellar Diseases	1.6%
723	Encephalitis	1.6%
724	Encephalomalacia	1.6%
725	Epilepsy	1.6%
726	Hydrocephalus	1.6%
727	Congenital Hydrocephalus	1.6%
728	Hyperglycemia	1.6%
729	Hyperinsulinism	1.6%
730	Hyperkalemia	1.6%
731	Hypernatremia	1.6%
732	Hypoglycemia	1.6%
733	Hypokalemia	1.6%
734	Hyponatremia	1.6%
735	Hypothalamic Diseases	1.6%
736	Aseptic Meningitis	1.6%
737	Neuritis	1.6%
738	Polyneuritis	1.6%
739	Radiculitis	1.6%
740	Syringomyelia	1.6%
741	Thalamic Diseases	1.6%
742	Xanthomatosis	1.6%
743	Hypophosphatemia	1.6%
744	Intracranial Hypertension	1.6%
745	Polyneuropathy	1.6%
746	Metabolic acidosis	1.6%
747	Mononeuritis	1.6%
748	Aura	1.6%
749	Dyslipidemias	1.6%
750	Leukoencephalopathy	1.6%
751	Essential Tremor	1.6%
752	Iron Overload	1.6%
753	Xanthoma	1.6%
754	Neuroaxonal Dystrophies	1.6%
755	Familial Tremor	1.6%
756	Headache Disorders	1.6%
757	Mononeuropathies	1.6%
758	Intracranial Hypotension	1.6%
759	Brachial Plexus Neuropathies	1.6%
760	Radiculopathy	1.6%
761	Mononeuropathy Multiplex	1.6%
762	Nerve Root Compression	1.6%
763	Brain Edema	1.6%
764	Brain Hypoxia	1.6%
765	Aqueductal Stenosis	1.6%
766	Pneumorrhachis	1.6%
767	Writer's Cramp	1.6%
768	Creutzfeldt-Jakob disease	1.6%
769	Basal Ganglia Cerebrovascular Disease	1.6%
770	Brain Injuries, Diffuse	1.6%
771	Traumatic Brain Injury	1.6%
772	Tarsal Tunnel Syndrome	1.6%
773	Cauda Equina Syndrome	1.6%
774	Posterior Leukoencephalopathy Syndrome	1.6%
775	Posterior reversible encephalopathy syndrome	1.6%
776	Supratentorial Neoplasms	1.6%
777	Multiple Sclerosis, Chronic Progressive	1.6%
778	Multiple Sclerosis, Relapsing-Remitting	1.6%
779	Tuberculosis, Meningeal	1.6%
780	Optic Nerve Glioma	1.6%
781	Anemia, Pernicious	1.6%
782	Scurvy	1.5%
783	Toxoplasmosis, Cerebral	1.5%
784	Brain Concussion	1.5%
785	Vertebral Artery Dissection	1.5%
786	Diabetes Mellitus	1.5%
787	Carpal Tunnel Syndrome	1.4%
788	Diabetic Ketoacidosis	1.4%
789	Vascular Headaches	1.4%
790	Cerebrovascular Disorders	1.4%
791	Dehydration	1.4%
792	Lipomatosis	1.4%
793	Myositis	1.4%
794	Optic Atrophy	1.4%
795	Optic Neuritis	1.4%
796	Papilledema	1.4%
797	Strabismus	1.4%
798	Tolosa-Hunt Syndrome	1.4%
799	Water Intoxication	1.4%
800	Cerebrovascular Insufficiency	1.4%
801	Isaacs syndrome	1.4%
802	Arsenic Poisoning	1.4%
803	Dementia	1.4%
804	Myotonic Disorders	1.4%
805	Central Nervous System Fungal Infections	1.4%
806	Conus Medullaris Syndrome	1.4%
807	Spinal Cord Vascular Diseases	1.4%
808	neurofibroma	1.4%
809	Hypoxia-Ischemia, Brain	1.4%
810	Sciatica	1.4%
811	Achlorhydria	1.4%
812	Diabetic Neuropathies	1.4%
813	Facial Injuries	1.4%
814	Facial Neuralgia	1.4%
815	Osteoporosis	1.4%
816	Bone Demineralization, Pathologic	1.4%
817	Diabetic Amyotrophy	1.4%
818	Diabetic Autonomic Neuropathy	1.4%
819	Sleep Talking	1.4%
820	Manganese Poisoning	1.4%
821	Post-Traumatic Osteoporosis	1.4%
822	Sleep Disorders, Intrinsic	1.4%
823	Orthostatic intolerance	1.4%
824	Celiac Disease	1.4%
825	Meningeal Neoplasms	1.4%
826	Neuralgia	1.4%
827	Sprue, Tropical	1.4%
828	Steatorrhea	1.4%
829	Sprue	1.4%
830	Mercury Poisoning, Nervous System	1.4%
831	Lead Poisoning, Nervous System	1.4%
832	Vestibular Neuronitis	1.4%
833	Neuropathic pain	1.4%
834	Acoustic Neuroma	1.4%
835	Myoclonic Epilepsy	1.4%
836	Epilepsy, Temporal Lobe	1.4%
837	Epilepsy, Rolandic	1.4%
838	Benign Rolandic Epilepsy	1.4%
839	Pituitary Adenoma	1.4%
840	Pituitary Neoplasms	1.4%
841	Cerebral Amyloid Angiopathy	1.3%
842	Hand-Arm Vibration Syndrome	1.3%
843	Meningitis, Cryptococcal	1.3%
844	Meningitis, Listeria	1.3%
845	Meningitis, Haemophilus	1.3%
846	Meningitis, Pneumococcal	1.3%
847	Fibromyalgia	1.3%
848	Optic Neuropathy, Ischemic	1.3%
849	Anterior Ischemic Optic Neuropathy	1.3%
850	Central Nervous System Bacterial Infections	1.3%
851	Medial Tibial Stress Syndrome	1.3%
852	Facial Hemiatrophy	1.3%
853	Melkersson-Rosenthal Syndrome	1.3%
854	Basal Ganglia Hemorrhage	1.2%
855	Eosinophilia-Myalgia Syndrome	1.2%
856	Sleep Bruxism	1.2%
857	Glycosuria	1.2%
858	Giant Cell Arteritis	1.2%
859	Temporal Arteritis	1.2%
860	Cubital Tunnel Syndrome	1.2%
861	Diffuse Axonal Injury	1.2%
862	Brain Stem Neoplasms	1.2%
863	Subarachnoid Hemorrhage, Traumatic	1.2%
864	Carotid Artery, Internal, Dissection	1.2%
865	HIV-Associated Lipodystrophy Syndrome	1.2%
866	Subacute Sclerosing Panencephalitis	1.2%
867	Juvenile Myoclonic Epilepsy	1.2%
868	Myoclonic Epilepsies, Progressive	1.2%
869	Bell Palsy	1.1%
870	Herpes Zoster Oticus	1.1%
871	Sleep Deprivation	1.1%
872	Necrobiosis Lipoidica Diabeticorum	1.1%
873	Pituitary Apoplexy	1.1%
874	Acidosis, Lactic	1.1%
875	Calciphylaxis	1.1%
876	Cerebral Palsy	1.1%
877	Epilepsies, Partial	1.1%
878	Epilepsy, Generalized	1.1%
879	Hemosiderosis	1.1%
880	Ketosis	1.1%
881	Pseudotumor Cerebri	1.1%
882	Sciatic Neuropathy	1.1%
883	Hypertensive Encephalopathy	1.1%
884	Ulnar Neuropathies	1.1%
885	Lesion of Sciatic Nerve	1.1%
886	Ketonuria	1.1%
887	Ketoacidosis	1.1%
888	Simple Partial Seizures	1.1%
889	Ketonemia	1.1%
890	Epilepsy, Reflex	1.1%
891	Ulnar Neuritis	1.1%
892	Vascular calcification	1.1%
893	Radial nerve compression	1.1%
894	Radial Tunnel Syndrome	1.1%
895	Peroneal Neuropathies	1.1%
896	Radial Neuropathy	1.1%
897	Median Neuropathy	1.1%
898	Sciatic Nerve Palsy	1.1%
899	Femoral Neuropathy	1.1%
900	Tibial Neuropathy	1.1%
901	Ulnar Nerve Palsy	1.1%
902	Postural Orthostatic Tachycardia Syndrome	1.1%
903	Radial nerve palsy	1.1%
904	Headache Disorders, Primary	1.1%
905	Headache Disorders, Secondary	1.1%
906	Medication overuse headache	1.1%
907	Brain Contusion	1.1%
908	Brain Infarction	1.1%
909	Putaminal Hemorrhage	1.1%
910	Infarction, Middle Cerebral Artery	1%
911	Infarction, Anterior Cerebral Artery	1%
912	Infarction, Posterior Cerebral Artery	1%
913	Choroid Plexus Papilloma	1%
914	Myalgia	1%
915	Pituitary Diseases	1%
916	Hematoma, Subdural	1%
917	Hematoma, Epidural, Cranial	1%
918	Thoracic Outlet Syndrome	0.9%
919	Acidosis, Respiratory	0.9%
920	Adiposis Dolorosa	0.9%
921	Alkalosis, Respiratory	0.9%
922	Carotid Artery Diseases	0.9%
923	Brain Ischemia	0.9%
924	Esotropia	0.9%
925	Exotropia	0.9%
926	Hypotension, Orthostatic	0.9%
927	Sleep Apnea Syndromes	0.9%
928	Cerebrovascular accident	0.9%
929	Polymyositis	0.9%
930	Kluver-Bucy Syndrome	0.9%
931	Vasospasm, Intracranial	0.9%
932	Spinal Cord Ischemia	0.9%
933	Intracranial Arterial Diseases	0.9%
934	Post-Exercise Hypotension	0.9%
935	Disorders of Excessive Somnolence	0.9%
936	Sleep Initiation and Maintenance Disorders	0.9%
937	Insulin Resistance	0.9%
938	Osteoporosis, Postmenopausal	0.9%
939	Night Terrors	0.9%
940	Somnambulism	0.9%
941	Trigeminal Nerve Disorder	0.9%
942	Transient Insomnia	0.9%
943	Sleep Paralysis	0.9%
944	Chronic Insomnia	0.9%
945	REM Sleep Behavior Disorder	0.9%
946	Hypersomnia	0.9%
947	Meningeal Carcinomatosis	0.9%
948	Lead Poisoning, Nervous System, Childhood	0.9%
949	Lead Poisoning, Nervous System, Adult	0.9%
950	Tuberculosis, Central Nervous System	0.9%
951	West Nile Fever	0.9%
952	Cerebral Infarction	0.9%
953	Brain Stem Infarctions	0.9%
954	Alcohol Withdrawal Delirium	0.9%
955	Moyamoya Disease	0.9%
956	Neurofibrosarcoma	0.9%
957	Eye Injuries	0.8%
958	Gestational Diabetes	0.8%
959	Latent Autoimmune Diabetes in Adults	0.8%
960	Diabetes Mellitus, Experimental	0.8%
961	Orbital Myositis	0.8%
962	Neuroaspergillosis	0.8%
963	Pyomyositis	0.8%
964	Intracranial Embolism and Thrombosis	0.8%
965	Nephrocalcinosis	0.8%
966	Hypercholesterolemia	0.8%
967	Hyperlipoproteinemias	0.8%
968	Hypertriglyceridemia	0.8%
969	Polyradiculopathy	0.8%
970	Post-Traumatic Headache	0.8%
971	Tension Headache	0.8%
972	Epilepsy, Complex Partial	0.8%
973	Migraine Disorders	0.8%
974	Abdominal Migraine	0.8%
975	Status Migrainosus	0.8%
976	Cervicogenic Headache	0.8%
977	Lateral Medullary Syndrome	0.8%
978	Hematoma, Subdural, Intracranial	0.8%
979	Hematoma, Subdural, Chronic	0.8%
980	Hematoma, Subdural, Acute	0.8%
981	Pseudorabies	0.8%
982	Primary amyloidosis	0.7%
983	Meningioma	0.7%
984	Neurosyphilis	0.7%
985	Empty Sella Syndrome	0.7%
986	Hyperpituitarism	0.7%
987	Hypopituitarism	0.7%
988	Hypophysitis	0.7%
989	Cerebral Arterial Diseases	0.7%
990	Vertebrobasilar Insufficiency	0.7%
991	Anterior Spinal Artery Syndrome	0.7%
992	Basilar Artery Stenosis	0.7%
993	Vertebral Artery Stenosis	0.7%
994	Sleep Apnea, Obstructive	0.7%
995	Sleep Apnea, Central	0.7%
996	Intracranial Hemorrhage, Hypertensive	0.7%
997	Transient Cerebral Ischemia	0.7%
998	Narcolepsy	0.7%
999	Trigeminal Neuralgia	0.7%
1000	Kleine-Levin Syndrome	0.7%
1001	Cluster Headache	0.7%
1002	Migraine with Aura	0.7%
1003	Familial Hemiplegic Migraine	0.7%
1004	Chronic Paroxysmal Hemicrania	0.7%
1005	SUNCT Syndrome	0.7%
1006	Paroxysmal Hemicrania	0.7%
1007	AIDS Dementia Complex	0.7%
1008	Lyme Neuroborreliosis	0.7%
1009	Waterhouse-Friderichsen Syndrome	0.6%
1010	Eye Burns	0.6%
1011	Malaria, Cerebral	0.6%
1012	Carotid Stenosis	0.6%
1013	Intracranial Aneurysm	0.6%
1014	Neurocysticercosis	0.6%
1015	Intracranial Arteriosclerosis	0.6%
1016	Cerebral Atherosclerosis	0.6%
1017	Subarachnoid Hemorrhage	0.6%
1018	Cerebral Arteriosclerosis	0.6%
1019	Cerebral Hemorrhage	0.6%
1020	Cerebral Thrombosis	0.6%
1021	Intracranial Embolism	0.6%
1022	Intracranial Thrombosis	0.6%
1023	CREST Syndrome	0.6%
1024	Hyperprolactinemia	0.6%
1025	Subclavian Steal Syndrome	0.6%
1026	Pick Disease of the Brain	0.6%
1027	Cataplexy	0.6%
1028	Dermatomyositis	0.6%
1029	Corneal Scar	0.6%
1030	Carotid Artery Thrombosis	0.5%
1031	Acromegaly	0.5%
1032	Sinus Thrombosis, Intracranial	0.5%
1033	Cavernous Sinus Thrombosis	0.5%
1034	Sagittal Sinus Thrombosis	0.5%
1035	Corneal Perforation	0.5%
1036	Prolactinoma	0.4%
1037	Growth Hormone-Secreting Pituitary Adenoma	0.4%
1038	Nelson Syndrome	0.4%

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