MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Scurvy

(UMLS:C0036474)

Definition:: An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.
UMLS ID:: C0036474
MeSH ID:: D012614

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.454.800

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.463.515.800

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.115.661

Synonym(s)

Scurvy

HYPOASCORBEMIA

SCORBUTUS

SCURVY

Vitamin C Deficiency

scorbutus

scurvies

scurvy

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ascorbic Acid		4538611 8698541 24162740	CTD
2	Prednisone		4538611	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Shwartzman Phenomenon	38.1%
2	Hemangioma, Cavernous	31.4%
3	Cryoglobulinemia	29.8%
4	Vitamin K Deficiency	28.9%
5	Purpura, Hyperglobulinemic	25.9%
6	Waldenstrom Macroglobulinemia	24.4%
7	Multiple Myeloma	23.3%
8	Disseminated Intravascular Coagulation	21.3%
9	Pseudoxanthoma Elasticum	19.2%
10	Thrombocythemia, Essential	18.8%
11	Vitamin A Deficiency	18.7%
12	Vitamin D Deficiency	18.7%
13	Vitamin E Deficiency	18.7%
14	Thrombasthenia	16.8%
15	Myocardial Ischemia	16.1%
16	Aortic Aneurysm	15.7%
17	Aortitis	15.7%
18	Leriche Syndrome	15.7%
19	Periphlebitis	15.7%
20	Phlebitis	15.7%
21	Thromboangiitis Obliterans	15.7%
22	Afibrinogenemia	15.4%
23	Factor VII Deficiency	15.4%
24	Factor X Deficiency	15.4%
25	Factor XII Deficiency	15.4%
26	Hemophilia A	15.4%
27	Factor II deficiency	15.4%
28	Factor VIII Deficiency	15.4%
29	Factor V deficiency	15.4%
30	Factor XI Deficiency	15.4%
31	Hypoprothrombinemias	15.4%
32	Magnesium Deficiency	15.2%
33	Potassium Deficiency	15.2%
34	Protein Deficiency	15.2%
35	Aneurysm	14.9%
36	Angiomatosis	14.9%
37	Aortic Diseases	14.9%
38	Arterial Occlusive Diseases	14.9%
39	Hyperemia	14.9%
40	Hypotension	14.9%
41	Superior Vena Cava Syndrome	14.9%
42	Telangiectasis	14.9%
43	Vasculitis	14.9%
44	Venous Insufficiency	14.9%
45	Peripheral Vascular Diseases	14.9%
46	Embolism and Thrombosis	14.9%
47	Angiodysplasia	14.9%
48	Capillary Leak Syndrome	14.9%
49	Prehypertension	14.9%
50	Protein S Deficiency	14.8%
51	Retinal Vein Occlusion	14.1%
52	Splenic Infarction	13.9%
53	Thrombophlebitis	13.7%
54	Postphlebitic Syndrome	13.7%
55	Malignant Atrophic Papulosis	13.1%
56	Myocardial Reperfusion Injury	13.1%
57	Coronary Aneurysm	13%
58	Starvation	12.8%
59	Refeeding Syndrome	12.8%
60	Aortic Rupture	12.6%
61	Folic Acid Deficiency	12.4%
62	Pellagra	12.4%
63	Thiamine Deficiency	12.4%
64	Vitamin B 12 Deficiency	12.4%
65	Vitamin B 6 Deficiency	12.4%
66	Pyridoxine Deficiency	12.4%
67	Vascular System Injuries	12.4%
68	Anemia	12.4%
69	Blood Coagulation Disorders	12.4%
70	Blood Platelet Disorders	12.4%
71	Bone Marrow Diseases	12.4%
72	Leukocyte Disorders	12.4%
73	Methemoglobinemia	12.4%
74	Pancytopenia	12.4%
75	Polycythemia	12.4%
76	Sulfhemoglobinemia	12.4%
77	Thrombophilia	12.4%
78	Erythrocytosis	12.4%
79	Blue Toe Syndrome	12.1%
80	Compartment syndromes	12.1%
81	Hepatic Veno-Occlusive Disease	12.1%
82	Peliosis Hepatis	12.1%
83	Varicocele	12.1%
84	Cerebrovascular Disorders	11.9%
85	Diabetic Angiopathies	11.9%
86	Reperfusion Injury	11.9%
87	Cerebrovascular Insufficiency	11.9%
88	Vascular Neoplasms	11.9%
89	Spinal Cord Vascular Diseases	11.9%
90	Vasoplegia	11.9%
91	Hemorrhoids	11.9%
92	Thoracic Outlet Syndrome	11.9%
93	Carotid Artery Thrombosis	11.7%
94	Aortic Aneurysm, Abdominal	11.6%
95	Aortic Aneurysm, Thoracic	11.6%
96	Moyamoya Disease	11.5%
97	Wiskott-Aldrich Syndrome	11.4%
98	Wasting Syndrome	11.4%
99	Intracranial Embolism and Thrombosis	11.4%
100	Carotid Stenosis	11.3%
101	Intracranial Aneurysm	11.3%
102	Coronary Thrombosis	11.3%
103	Coronary Artery Disease	11.3%
104	Antithrombin III Deficiency	11.2%
105	Protein C Deficiency	11.2%
106	Arteriovenous fistula	10.8%
107	Child Nutrition Disorders	10.6%
108	Hypervitaminosis A	10.6%
109	Infant Nutrition Disorders	10.6%
110	Coronary heart disease	10.5%
111	Myocardial Infarction	10.5%
112	Acute Coronary Syndrome	10.5%
113	Transfusion Reaction	10.4%
114	Hypotensive Transfusion Reaction	10.4%
115	Anemia, Pernicious	10.3%
116	Hand-Arm Vibration Syndrome	10.3%
117	Pregnancy Complications, Hematologic	10.1%
118	Hematologic Neoplasms	10.1%
119	Optic Neuropathy, Ischemic	10.1%
120	Anterior Ischemic Optic Neuropathy	10.1%
121	Mesenteric vascular insufficiency	10.1%
122	Vasculitis, Central Nervous System	9.9%
123	Angioedema	9.8%
124	Bone Marrow Neoplasms	9.8%
125	Colitis, Ischemic	9.8%
126	Activated Protein C Resistance	9.8%
127	Aneurysm, Dissecting	9.8%
128	Arteriosclerosis	9.8%
129	Arteritis	9.8%
130	Embolism	9.8%
131	Erythromelalgia	9.8%
132	Fibromuscular Dysplasia	9.8%
133	Malignant Hypertension	9.8%
134	Raynaud Disease	9.8%
135	Thromboembolism	9.8%
136	Thrombosis	9.8%
137	Essential Hypertension	9.8%
138	Aneurysm, Ruptured	9.8%
139	Iliac Aneurysm	9.8%
140	Pulmonary artery stenosis	9.8%
141	White Coat Hypertension	9.8%
142	Systemic Vasculitis	9.8%
143	Embolus	9.8%
144	Thrombocytosis	9.8%
145	Polyarteritis Nodosa	9.7%
146	Takayasu Arteritis	9.7%
147	Intracranial Arteriosclerosis	9.7%
148	Cerebral Atherosclerosis	9.7%
149	Cerebral Arteriosclerosis	9.7%
150	Autoimmune thrombocytopenia	9.6%
151	Immune thrombocytopenic purpura	9.6%
152	Mucocutaneous Lymph Node Syndrome	9.4%
153	Beriberi	9.3%
154	Rickets	9.3%
155	Marasmus	9.1%
156	Kounis Syndrome	8.9%
157	Cerebral Thrombosis	8.8%
158	Intracranial Embolism	8.8%
159	Intracranial Thrombosis	8.8%
160	Hyperhomocysteinemia	8.8%
161	Giant Cell Arteritis	8.8%
162	Temporal Arteritis	8.8%
163	May-Thurner Syndrome	8.7%
164	Angina Pectoris	8.7%
165	Heart Diseases	8.6%
166	Polycythemia Vera	8.3%
167	Brain Infarction	8.3%
168	Embolism, Amniotic Fluid	8.3%
169	Scimitar Syndrome	8.2%
170	CREST Syndrome	8%
171	Retinal Artery Occlusion	8%
172	Retinal Vasculitis	8%
173	Hypertensive Retinopathy	8%
174	Lemierre Syndrome	7.9%
175	Anterior Compartment Syndrome	7.9%
176	Vasculitis, Leukocytoclastic, Cutaneous	7.9%
177	Gastric Antral Vascular Ectasia	7.9%
178	Abdominal Compartment Syndrome	7.9%
179	Carotid Artery Diseases	7.8%
180	Brain Ischemia	7.8%
181	Hypotension, Orthostatic	7.8%
182	Cerebrovascular accident	7.8%
183	Varicose Ulcer	7.8%
184	Vasospasm, Intracranial	7.8%
185	Spinal Cord Ischemia	7.8%
186	Intracranial Arterial Diseases	7.8%
187	Primary Graft Dysfunction	7.8%
188	Post-Exercise Hypotension	7.8%
189	Hemoglobinuria, Paroxysmal	7.8%
190	Leukemoid Reaction	7.8%
191	Coronary Occlusion	7.8%
192	Microvascular Angina	7.8%
193	Coronary Stenosis	7.8%
194	ST segment elevation myocardial infarction	7.8%
195	Lymphatic Diseases	7.7%
196	Subarachnoid Hemorrhage, Traumatic	7.7%
197	Carotid Artery, Internal, Dissection	7.7%
198	Sinus Thrombosis, Intracranial	7.6%
199	Infarction, Middle Cerebral Artery	7.4%
200	Infarction, Anterior Cerebral Artery	7.4%
201	Infarction, Posterior Cerebral Artery	7.4%
202	Anemia, Hemolytic	7.3%
203	Anemia, Macrocytic	7.3%
204	Eosinophilia	7.3%
205	Hypoproteinemia	7.3%
206	Leukopenia	7.3%
207	Thrombocytopenia	7.3%
208	Leukostasis	7.3%
209	MYELODYSPLASTIC SYNDROME	7.3%
210	Vertebral Artery Dissection	7.3%
211	Arteriosclerosis Obliterans	7.3%
212	Atherosclerosis	7.3%
213	Air Embolism	7.3%
214	Endarteritis	7.3%
215	Venous Thrombosis	7.3%
216	Deep Vein Thrombosis	7.3%
217	Venous Thromboembolism	7.3%
218	Waterhouse-Friderichsen Syndrome	7.3%
219	Kwashiorkor	7.1%
220	Metabolic Diseases	7.1%
221	Cavernous Sinus Thrombosis	7%
222	Sagittal Sinus Thrombosis	7%
223	Purpura, Thrombotic Thrombocytopenic	6.9%
224	Anemia, Diamond-Blackfan	6.9%
225	Pregnancy Complications, Cardiovascular	6.9%
226	Cardiovascular Abnormalities	6.9%
227	Cerebral Infarction	6.8%
228	Brain Stem Infarctions	6.8%
229	Agammaglobulinemia	6.6%
230	Mesenteric Vascular Occlusion	6.6%
231	Diabetic Retinopathy	6.6%
232	Sturge-Weber Syndrome	6.6%
233	Livedo Reticularis	6.6%
234	Renal hypertension	6.5%
235	Renal Artery Obstruction	6.5%
236	Renal Artery Stenosis	6.5%
237	Shock, Cardiogenic	6.5%
238	Basal Ganglia Cerebrovascular Disease	6.5%
239	Osteomalacia	6.5%
240	Carotid Artery Injuries	6.5%
241	Vascular Headaches	6.5%
242	Angina, Unstable	6.4%
243	Coronary Restenosis	6.4%
244	Anemia, Sickle Cell	6.3%
245	Thalassemia	6.3%
246	Lateral Medullary Syndrome	6.1%
247	Anemia, Neonatal	6%
248	Leukocytosis	6%
249	Paraproteinemias	6%
250	Pelger-Huet Anomaly	6%
251	Pleocytosis	6%
252	Intermittent Claudication	5.9%
253	Pulmonary Embolism	5.9%
254	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5.9%
255	Basal Ganglia Hemorrhage	5.9%
256	No-Reflow Phenomenon	5.9%
257	Cerebral Arterial Diseases	5.8%
258	Vertebrobasilar Insufficiency	5.8%
259	Anterior Spinal Artery Syndrome	5.8%
260	Basilar Artery Stenosis	5.8%
261	Vertebral Artery Stenosis	5.8%
262	Intracranial Hemorrhage, Hypertensive	5.8%
263	Transient Cerebral Ischemia	5.8%
264	Wernicke Encephalopathy	5.6%
265	Ischemic contracture	5.6%
266	Angioedemas, Hereditary	5.6%
267	Infectious Mononucleosis	5.6%
268	Tricuspid Atresia	5.6%
269	Arrhythmogenic Right Ventricular Dysplasia	5.6%
270	Leukomalacia, Periventricular	5.6%
271	Monoclonal Gammopathy of Undetermined Significance	5.6%
272	Diabetic Foot	5.5%
273	Angina Pectoris, Variant	5.3%
274	Aortic Valve Stenosis	5.2%
275	Cardiomyopathy, Dilated	5.2%
276	Pulmonary Valve Stenosis	5.2%
277	Fanconi Anemia	5.2%
278	Hypergammaglobulinemia	5%
279	Putaminal Hemorrhage	5%
280	Cardiac Tamponade	5%
281	Endocarditis	5%
282	Cardiac Arrest	5%
283	Heart failure	5%
284	Pericardial effusion	5%
285	Pericarditis	5%
286	Pneumopericardium	5%
287	Cor pulmonale	5%
288	Ventricular Outflow Obstruction	5%
289	Ventricular Dysfunction	5%
290	Cardiomyopathies	5%
291	Pleuropericarditis	5%
292	Transfusion-Related Acute Lung Injury	5%
293	Hepatic Vein Thrombosis	4.9%
294	Budd-Chiari Syndrome	4.9%
295	Ecchymosis	4.9%
296	Petechiae	4.9%
297	Purpura	4.9%
298	Heavy Chain Disease	4.9%
299	Shy-Drager Syndrome	4.9%
300	Pulmonary Infarction	4.9%
301	Primary Myelofibrosis	4.8%
302	Agranulocytosis	4.8%
303	Anemia, Megaloblastic	4.8%
304	Lymphocytosis	4.8%
305	Myelofibrosis	4.8%
306	Myeloid Metaplasia	4.8%
307	Hypoalbuminemia	4.8%
308	Hypereosinophilic syndrome	4.8%
309	bone marrow fibrosis	4.8%
310	Thrombotic Microangiopathies	4.8%
311	Hypertension, Renovascular	4.8%
312	Subarachnoid Hemorrhage	4.8%
313	Hypoxia-Ischemia, Brain	4.8%
314	Cerebral Hemorrhage	4.8%
315	Subacute Combined Degeneration	4.8%
316	Dementia, Vascular	4.8%
317	Hemolytic-Uremic Syndrome	4.8%
318	Subclavian Steal Syndrome	4.8%
319	Hereditary Angioedema Type III	4.8%
320	Hereditary Angioedema Types I and II	4.8%
321	Bacterial Endocarditis	4.8%
322	Ataxia Telangiectasia	4.7%
323	Cerebral Amyloid Angiopathy	4.7%
324	Renal Osteodystrophy	4.6%
325	Renal rickets	4.6%
326	Sickle Cell Trait	4.5%
327	Hydrops Fetalis	4.4%
328	Behcet Syndrome	4.4%
329	Heart Block	4.4%
330	Tachycardia	4.4%
331	Tachyarrhythmia	4.4%
332	Aortic coarctation	4.4%
333	Cor Triatriatum	4.4%
334	Coronary Vessel Anomalies	4.4%
335	Patent ductus arteriosus	4.4%
336	Ebstein Anomaly	4.4%
337	Heart Septal Defects	4.4%
338	Tetralogy of Fallot	4.4%
339	Transposition of Great Vessels	4.4%
340	Hypoplastic Left Heart Syndrome	4.4%
341	Thrombocytopenic purpura	4.4%
342	Hypertrophic Cardiomyopathy	4.2%
343	Hypertrophic obstructive cardiomyopathy	4.2%
344	Pituitary Apoplexy	4.2%
345	Lupus Vasculitis, Central Nervous System	4.2%
346	Adenitis	4.1%
347	Histiocytosis	4.1%
348	Lymphadenitis	4.1%
349	Lymphangitis	4.1%
350	Lymphedema	4.1%
351	Splenic Diseases	4.1%
352	Thymus Hyperplasia	4.1%
353	Pseudolymphoma	4.1%
354	Lymphadenopathy	4.1%
355	Kernicterus	4.1%
356	Granulomatosis with polyangiitis	4.1%
357	Cardiac Output, High	4%
358	Myocardial Stunning	4%
359	Low Cardiac Output Syndrome	4%
360	Cardiomegaly	4%
361	Postpericardiotomy Syndrome	4%
362	Cardiac Hypertrophy	4%
363	Lymphopenia	4%
364	Rheumatic Heart Disease	3.9%
365	Job Syndrome	3.9%
366	Supravalvular aortic stenosis	3.9%
367	Leukemia, Myelomonocytic, Chronic	3.9%
368	Lown-Ganong-Levine Syndrome	3.9%
369	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.9%
370	Atypical Hemolytic Uremic Syndrome	3.8%
371	Dextrocardia	3.7%
372	Long QT Syndrome	3.7%
373	HIV Wasting Syndrome	3.7%
374	Rheumatoid Vasculitis	3.7%
375	Sick Sinus Syndrome	3.6%
376	Neutropenia	3.6%
377	Acute Chest Syndrome	3.6%
378	Acid-Base Imbalance	3.5%
379	Calcium Metabolism Disorders	3.5%
380	Iron Metabolism Disorders	3.5%
381	Phosphorus Metabolism Disorders	3.5%
382	Water-Electrolyte Imbalance	3.5%
383	Lipid Metabolism Disorders	3.5%
384	Mitochondrial Diseases	3.5%
385	Glucose Metabolism Disorders	3.5%
386	Lymphocele	3.4%
387	Lymphoproliferative Disorders	3.4%
388	Lymphatic Abnormalities	3.4%
389	Thymus Neoplasms	3.3%
390	Eosinophilia-Myalgia Syndrome	3.3%
391	Lymphangiectasis, Intestinal	3.3%
392	Eosinophilic Granuloma	3.3%
393	MELAS Syndrome	3.3%
394	Chronic granulomatous disease	3.3%
395	Aortic Valve Insufficiency	3.3%
396	Restrictive cardiomyopathy	3.3%
397	Endocardial Fibroelastosis	3.3%
398	Heart Rupture, Post-Infarction	3.3%
399	Mitral Valve Insufficiency	3.3%
400	Mitral Valve Stenosis	3.3%
401	Myocarditis	3.3%
402	Pericarditis, Constrictive	3.3%
403	Pulmonary Valve Insufficiency	3.3%
404	Tricuspid Valve Insufficiency	3.3%
405	Tricuspid Valve Stenosis	3.3%
406	Ventricular Dysfunction, Left	3.3%
407	Right Ventricular Dysfunction	3.3%
408	Endomyocardial Fibrosis	3.3%
409	Carditis	3.3%
410	Heart Failure, Systolic	3.3%
411	Heart Failure, Diastolic	3.3%
412	Adams-Stokes Syndrome	3.2%
413	Atrioventricular Block	3.2%
414	Bundle-Branch Block	3.2%
415	Atrial Premature Complexes	3.2%
416	Sinoatrial Block	3.2%
417	Tachycardia, Paroxysmal	3.2%
418	Supraventricular tachycardia	3.2%
419	Tachycardia, Ventricular	3.2%
420	Wolff-Parkinson-White Syndrome	3.2%
421	Purpura Fulminans	3.2%
422	Tachycardia, Reciprocating	3.2%
423	Aortopulmonary Septal Defect	3.2%
424	Double Outlet Right Ventricle	3.2%
425	Endocardial Cushion Defects	3.2%
426	Myocardial bridging	3.2%
427	Aorticopulmonary Septal Defect	3.2%
428	Obesity	3.1%
429	Febrile Neutropenia	3%
430	Familial Hypophosphatemic Rickets	3%
431	Pulmonary Eosinophilia	3%
432	Eosinophilic Pneumonia	3%
433	Hypercalcemia	2.9%
434	Hypocalcemia	2.9%
435	Milk-Alkali Syndrome	2.9%
436	Noonan Syndrome	2.9%
437	Leukemia, Myeloid, Chronic-Phase	2.9%
438	Osteopenia	2.9%
439	Subacute Bacterial Endocarditis	2.8%
440	Brain Diseases, Metabolic	2.8%
441	POEMS Syndrome	2.8%
442	Carcinoid Heart Disease	2.8%
443	Romano-Ward Syndrome	2.8%
444	Hematoma, Subdural	2.7%
445	Hematoma, Epidural, Cranial	2.7%
446	Tachycardia, Atrioventricular Nodal Reentry	2.7%
447	Tachycardia, Ectopic Atrial	2.7%
448	Tachycardia, Ectopic Junctional	2.7%
449	Sinus Tachycardia	2.7%
450	Torsades de Pointes	2.7%
451	Accelerated Idioventricular Rhythm	2.7%
452	Marfan Syndrome	2.7%
453	Truncus Arteriosus, Persistent	2.7%
454	Sinus Arrhythmia	2.6%
455	Atrial Fibrillation	2.6%
456	Atrial Flutter	2.6%
457	Edema, Cardiac	2.6%
458	Ventricular Fibrillation	2.6%
459	Ventricular Flutter	2.6%
460	Parasystole	2.6%
461	Paroxysmal atrial fibrillation	2.6%
462	Bradycardia	2.6%
463	Diabetic Cardiomyopathies	2.6%
464	Cardiomyopathy, Alcoholic	2.6%
465	Ectopia Cordis	2.6%
466	Sudden Cardiac Death	2.6%
467	Left Ventricular Hypertrophy	2.6%
468	Right Ventricular Hypertrophy	2.6%
469	Single umbilical artery	2.6%
470	Chagas Cardiomyopathy	2.6%
471	Fabry Disease	2.5%
472	Lipodystrophy	2.5%
473	Elephantiasis	2.4%
474	Hypersplenism	2.4%
475	Sarcoidosis	2.4%
476	Elephantiasis Nostras Verrucosa	2.4%
477	Aortic Valve Prolapse	2.4%
478	Tricuspid Valve Prolapse	2.4%
479	Takotsubo Cardiomyopathy	2.4%
480	Brain Hemorrhage, Traumatic	2.4%
481	Hematoma, Subdural, Intracranial	2.4%
482	Hematoma, Subdural, Chronic	2.4%
483	Hematoma, Subdural, Acute	2.4%
484	Pseudohypoparathyroidism	2.3%
485	Dyspnea, Paroxysmal	2.2%
486	Brain Diseases, Metabolic, Inborn	2.1%
487	Obesity, Abdominal	2%
488	Granuloma	2%
489	Histiocytic Disorders, Malignant	2%
490	Splenic Neoplasms	2%
491	Histiocytosis, Langerhans-Cell	2%
492	Tumor Lysis Syndrome	2%
493	Sinus Arrest, Cardiac	1.9%
494	Dural Arteriovenous Fistula	1.9%
495	Acidosis	1.8%
496	Alkalosis	1.8%
497	Amyloidosis	1.8%
498	Calcinosis	1.8%
499	Hyperglycemia	1.8%
500	Hyperinsulinism	1.8%
501	Hyperkalemia	1.8%
502	Hypernatremia	1.8%
503	Hypoglycemia	1.8%
504	Hypokalemia	1.8%
505	Hyponatremia	1.8%
506	Xanthomatosis	1.8%
507	Hypophosphatemia	1.8%
508	Metabolic acidosis	1.8%
509	Dyslipidemias	1.8%
510	Iron Overload	1.8%
511	Xanthoma	1.8%
512	Leigh Disease	1.8%
513	Kearns-Sayre syndrome	1.7%
514	Pediatric Obesity	1.7%
515	Splenic Rupture	1.7%
516	Sezary Syndrome	1.7%
517	Lymphoma	1.7%
518	Thymoma	1.6%
519	Lactose Intolerance	1.6%
520	Lymphohistiocytosis, Hemophagocytic	1.6%
521	Erdheim-Chester Disease	1.6%
522	Turner Syndrome	1.6%
523	Diabetes Mellitus	1.5%
524	Prader-Willi Syndrome	1.5%
525	Dehydration	1.5%
526	Lipomatosis	1.5%
527	Water Intoxication	1.5%
528	Werner Syndrome	1.5%
529	Achlorhydria	1.5%
530	Amino Acid Metabolism, Inborn Errors	1.5%
531	Bloom Syndrome	1.5%
532	Carbohydrate Metabolism, Inborn Errors	1.5%
533	Metal Metabolism, Inborn Errors	1.5%
534	Osteoporosis	1.5%
535	Progeria	1.5%
536	Lysosomal Storage Diseases	1.5%
537	Bone Demineralization, Pathologic	1.5%
538	Cytochrome-c Oxidase Deficiency	1.5%
539	Peroxisomal Disorders	1.5%
540	Post-Traumatic Osteoporosis	1.5%
541	Celiac Disease	1.5%
542	Sprue, Tropical	1.5%
543	Steatorrhea	1.5%
544	Sprue	1.5%
545	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.4%
546	Autoimmune Lymphoproliferative Syndrome	1.4%
547	Mitochondrial Encephalomyopathies	1.4%
548	Smith-Lemli-Opitz Syndrome	1.4%
549	Hypolipoproteinemias	1.3%
550	Galactosemias	1.3%
551	Urea Cycle Disorders, Inborn	1.3%
552	Tyrosinemias	1.3%
553	Kartagener Syndrome	1.3%
554	Malignant histiocytosis	1.3%
555	Sarcoidosis, Pulmonary	1.3%
556	Histiocytic sarcoma	1.3%
557	Mitochondrial Myopathies	1.2%
558	Myelinolysis, Central Pontine	1.2%
559	Glycosuria	1.2%
560	Reye Syndrome	1.2%
561	Hepatic Encephalopathy	1.2%
562	Hyperphosphaturia	1.2%
563	Congenital Hyperinsulinism	1.2%
564	Williams Syndrome	1.2%
565	Splenosis	1.1%
566	Hodgkin Disease	1.1%
567	Lymphoma, Non-Hodgkin	1.1%
568	Diabetic Ketoacidosis	1.1%
569	Leukemia, T-Cell	1.1%
570	Leukemia, B-Cell	1.1%
571	Hyperlipidemia, Familial Combined	1.1%
572	Porphyrias, Hepatic	1.1%
573	Homocystinuria	1.1%
574	Necrobiosis Lipoidica Diabeticorum	1.1%
575	Hyperlipoproteinemia Type IV	1%
576	Hyperlipoproteinemia Type V	1%
577	Acidosis, Lactic	1%
578	Calciphylaxis	1%
579	Hemosiderosis	1%
580	Ketosis	1%
581	Ketonuria	1%
582	Ketoacidosis	1%
583	Ketonemia	1%
584	Vascular calcification	1%
585	Renal tubular acidosis	1%
586	Zellweger Syndrome	0.9%
587	Hyperlipoproteinemia Type III	0.9%
588	Composite Lymphoma	0.9%
589	Menkes Kinky Hair Syndrome	0.9%
590	Lymphangioleiomyomatosis	0.9%
591	Friedreich Ataxia	0.9%
592	HIV-Associated Lipodystrophy Syndrome	0.9%
593	Amyloid Neuropathies, Familial	0.9%
594	Adrenoleukodystrophy	0.9%
595	Hepatolenticular Degeneration	0.9%
596	Glycogen storage disease type II	0.9%
597	Refsum Disease	0.9%
598	Niemann-Pick Disease, Type C	0.9%
599	Cockayne Syndrome	0.8%
600	Acidosis, Respiratory	0.8%
601	Adiposis Dolorosa	0.8%
602	Alkalosis, Respiratory	0.8%
603	Neuronal Ceroid-Lipofuscinoses	0.8%
604	Alkaptonuria	0.8%
605	Glycogen Storage Disease	0.8%
606	Hypophosphatasia	0.8%
607	Insulin Resistance	0.8%
608	Osteoporosis, Postmenopausal	0.8%
609	Propionic acidemia	0.8%
610	Dihydropyrimidine Dehydrogenase Deficiency	0.8%
611	Cystinosis	0.8%
612	Glycosuria, Renal	0.8%
613	Lymphoma, Follicular	0.8%
614	T-Cell Lymphoma	0.8%
615	Mantle cell lymphoma	0.8%
616	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
617	Hypoalphalipoproteinemias	0.8%
618	Leukemia, Large Granular Lymphocytic	0.8%
619	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
620	Optic Atrophy, Hereditary, Leber	0.7%
621	Gaucher Disease	0.7%
622	Gestational Diabetes	0.7%
623	Latent Autoimmune Diabetes in Adults	0.7%
624	Nesidioblastosis	0.7%
625	Diabetes Mellitus, Experimental	0.7%
626	Xeroderma Pigmentosum	0.7%
627	Nephrocalcinosis	0.7%
628	Tetany	0.7%
629	Lymphoma, T-Cell, Cutaneous	0.7%
630	Lymphoma, AIDS-Related	0.7%
631	Enteropathy-Associated T-Cell Lymphoma	0.7%
632	Primary Effusion Lymphoma	0.7%
633	Hypercholesterolemia	0.6%
634	Hyperlipoproteinemias	0.6%
635	Hypertriglyceridemia	0.6%
636	Mucopolysaccharidosis III	0.6%
637	Mycosis Fungoides	0.6%
638	Lymphomatoid Papulosis	0.6%
639	Plasmablastic lymphoma	0.6%
640	Familial Periodic Paralysis	0.6%
641	Primary amyloidosis	0.6%
642	Lymphomatoid Granulomatosis	0.6%
643	Variegate Porphyria	0.6%
644	Acute intermittent porphyria	0.6%
645	Porphyria Cutanea Tarda	0.6%
646	Renal Aminoacidurias	0.6%
647	Fanconi Syndrome	0.6%
648	Pseudohypoaldosteronism	0.6%
649	Liddle Syndrome	0.6%
650	Sjogren-Larsson Syndrome	0.5%
651	Gout	0.5%
652	Amyotrophic Lateral Sclerosis	0.5%
653	Antley-Bixler Syndrome Phenotype	0.5%
654	Burkitt Lymphoma	0.5%
655	Glycogen Storage Disease Type I	0.5%
656	Glycogen Storage Disease Type V	0.5%
657	Canavan Disease	0.4%
658	Alexander Disease	0.4%
659	Mucopolysaccharidosis II	0.4%
660	Tay-Sachs Disease	0.4%
661	Albinism	0.4%
662	Hypokalemic periodic paralysis	0.3%
663	Frontotemporal dementia	0.3%
664	Cystinuria	0.3%
665	Ichthyosis, X-Linked	0.3%
666	Arthritis, Gouty	0.3%

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