MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteoarthritis, Knee

(UMLS:C0409959)

Definition:: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
UMLS ID:: C0409959
MeSH ID:: D020370

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.550.114.606.500|C05.799.613.500

Synonym(s)

Osteoarthritis, Knee

Degenerative joint disease of knee

Gonarthrosis

Knee DJD (degenerative joint disease)

Knee osteoarthritis

OA - Osteoarthritis of knee

OSTEOARTHRITIS SUSCEPTIBILITY 6

Osteoarthritis of knee

Osteoarthritis of knee, unspecified

10.

Osteoarthritis;knee

11.

Osteoarthrosis of knee

12.

knee osteoarthritis

13.

knee osteoarthrosis

14.

osteoarthritis of knee

15.

osteoarthrosis of knee

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Pregabalin	19664204	CTD
2	Resveratrol	15883738	CTD
3	Tramadol	12355682	CTD
4	nimesulide	12166616	CTD
5	rofecoxib	14633764	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Osteoarthritis, Spine	46.1%
2	Rheumatic Fever	32%
3	Periarthritis	31.4%
4	Gout	28.9%
5	Sacroiliitis	27.5%
6	Contracture	27.4%
7	Osteoarthropathy, Secondary Hypertrophic	27.4%
8	Rheumatoid Arthritis	27.1%
9	Juvenile arthritis	27.1%
10	Arthrogryposis	24.6%
11	Bursitis	23.6%
12	Joint Instability	23.6%
13	Synovitis	23.6%
14	Joint laxity	23.6%
15	Frozen shoulder	23.6%
16	Patellofemoral Pain Syndrome	23.6%
17	Fibromyalgia	23.1%
18	Polymyalgia Rheumatica	23.1%
19	Arthritis, Psoriatic	22.4%
20	Bone Diseases	22.4%
21	Fasciitis	22.4%
22	Foot Deformities	22.4%
23	Metatarsalgia	21.6%
24	Arthritis, Infectious	21%
25	Rheumatoid Nodule	20.9%
26	Arthritis, Experimental	20.7%
27	Ankylosing spondylitis	19.1%
28	Arthritis, Gouty	19%
29	Fasciitis, Plantar	18.8%
30	Arthritis, Reactive	18.1%
31	Hemarthrosis	17.6%
32	Felty Syndrome	17.5%
33	Jaw Diseases	17.4%
34	Spondylarthropathies	17%
35	Cartilage Diseases	16.8%
36	Foot Diseases	16.8%
37	Myopathy	16.8%
38	Chondromalacia	16.8%
39	Hip Contracture	16.5%
40	Temporomandibular Joint Disorders	16.1%
41	Osteochondritis	15%
42	Rheumatoid Vasculitis	15%
43	Ischemic contracture	14.9%
44	Pectus carinatum	14%
45	Sicca Syndrome	13.1%
46	Sjogren's Syndrome	13.1%
47	Bone Diseases, Developmental	12.4%
48	Hyperostosis	12.4%
49	Myofascial Pain Syndromes	12.4%
50	Osteitis	12.4%
51	Osteitis Deformans	12.4%
52	Osteochondrosis	12.4%
53	Rhabdomyolysis	12.4%
54	Spinal Diseases	12.4%
55	Pectus excavatum	12.1%
56	Temporomandibular Joint Dysfunction Syndrome	11.9%
57	Nail-Patella Syndrome	11.9%
58	Arthropathy	11.8%
59	Arthralgia	11.5%
60	Platybasia	11.5%
61	Polyarthralgia	11.5%
62	Klippel-Feil Syndrome	10.7%
63	Synostosis	10.7%
64	Talipes	9.8%
65	Bone Diseases, Endocrine	9.7%
66	Bone Diseases, Infectious	9.4%
67	Bone neoplasms	9.4%
68	Compartment syndromes	9.4%
69	Maxillary Diseases	9.4%
70	Osteopenia	9.4%
71	Tendinitis	9.4%
72	Tendinopathy	9.4%
73	Gigantism	9.3%
74	Spinal Neoplasms	9.3%
75	Spondylitis	9.3%
76	Bone Resorption	9.2%
77	Myositis	9.2%
78	Tietze's Syndrome	9.2%
79	Limb Deformities, Congenital	9.2%
80	Isaacs syndrome	9.2%
81	Craniofacial Abnormalities	9.2%
82	Aseptic Necrosis of Bone	9.2%
83	Myotonic Disorders	9.2%
84	Hip Dislocation	8.8%
85	Shoulder Dislocation	8.8%
86	Hip Dysplasia	8.8%
87	Craniosynostosis	8.4%
88	Syndactyly	8.4%
89	Brachycephaly	8.4%
90	Rheumatism	8%
91	Craniofacial Dysostosis	7.8%
92	Ainhum	7.7%
93	Bunion	7.7%
94	Dysostoses	7.7%
95	Fibrodysplasia Ossificans Progressiva	7.7%
96	Myoglobinuria	7.7%
97	Myositis Ossificans	7.7%
98	Spinal Stenosis	7.7%
99	Spondylosis	7.7%
100	Tenosynovitis	7.7%
101	Intervertebral Disc Degeneration	7.7%
102	Medial Tibial Stress Syndrome	7.5%
103	Mitochondrial Myopathies	7.4%
104	Muscle Cramp	7.3%
105	Eosinophilia-Myalgia Syndrome	7.3%
106	Gastroschisis	7.3%
107	Muscle Rigidity	7.3%
108	Muscle Spasticity	7.3%
109	Cogwheel Rigidity	7.3%
110	Nuchal Rigidity	7.3%
111	Congenital clubfoot	7.2%
112	Vertical Talus	7.2%
113	Acrocephalosyndactylia	7.2%
114	Shoulder Pain	7%
115	Arthritis	6.7%
116	Polyarthritis	6.7%
117	Jaw Abnormalities	6.7%
118	Discitis	6.5%
119	Chronic Fatigue Syndrome	6.4%
120	Poland Syndrome	6.2%
121	Giant Cell Epulis	6.2%
122	Muscle Weakness	6.2%
123	Musculoskeletal Pain	6.1%
124	Familial Periodic Paralysis	6.1%
125	Multiple Epiphyseal Dysplasia	5.9%
126	Osteochondrodysplasias	5.9%
127	Prognathism	5.9%
128	Anterior Compartment Syndrome	5.8%
129	Osteomyelitis	5.8%
130	Osteoporosis	5.8%
131	Periostitis	5.8%
132	Enthesopathy	5.8%
133	Bone Demineralization, Pathologic	5.8%
134	Post-Traumatic Osteoporosis	5.8%
135	Abdominal Compartment Syndrome	5.8%
136	Alveolar Bone Loss	5.7%
137	Amelia	5.7%
138	Arachnodactyly	5.7%
139	Ectromelia	5.7%
140	Femur Head Necrosis	5.7%
141	Hemimelia	5.7%
142	Phocomelia	5.7%
143	Sirenomelia	5.7%
144	Polymyositis	5.7%
145	Polydactyly	5.7%
146	Brachydactyly	5.7%
147	Plagiocephaly	5.7%
148	Lower Extremity Deformities, Congenital	5.7%
149	Upper Extremity Deformities, Congenital	5.7%
150	Osteolysis	5.7%
151	Congenital Hypothyroidism	5.7%
152	Chondrodysplasia Punctata	5.4%
153	Enchondromatosis	5.4%
154	Lordosis	5.4%
155	Osteosclerosis	5.4%
156	Spondylolysis	5.4%
157	kyphosis	5.4%
158	Kashin-Beck Disease	5.4%
159	Tuberculosis, Spinal	5.4%
160	Laryngomalacia	5.4%
161	Eosinophilic Granuloma	5.2%
162	Myalgia	5.2%
163	Antley-Bixler Syndrome Phenotype	5.1%
164	Osteoarthritis, Knee	4.9%
165	Dwarfism	4.9%
166	Mandibulofacial Dysostosis	4.9%
167	Goldenhar Syndrome	4.8%
168	Muscular Dystrophy	4.7%
169	Orbital Myositis	4.7%
170	Dupuytren Contracture	4.6%
171	Pyomyositis	4.6%
172	Acromegaly	4.6%
173	Joint Tuberculosis	4.6%
174	Tuberculosis, Osteoarticular	4.6%
175	Bone Tuberculosis	4.6%
176	Palatal Neoplasms	4.5%
177	Micrognathism	4.5%
178	Pierre Robin Syndrome	4.5%
179	Rubinstein-Taybi Syndrome	4.4%
180	Myotonic Dystrophy	4.4%
181	Melorheostosis	4.3%
182	Osteopetrosis	4.3%
183	Spondylolisthesis	4.3%
184	Osteoporosis, Postmenopausal	4.1%
185	Retrognathia	4%
186	Maxillofacial Abnormalities	3.9%
187	Myotonia Congenita	3.8%
188	Rickets	3.8%
189	Bronchomalacia	3.8%
190	Tracheomalacia	3.8%
191	Microcephaly	3.8%
192	Macrocephaly	3.8%
193	Hypokalemic periodic paralysis	3.8%
194	Basal Cell Nevus Syndrome	3.6%
195	Osteogenesis Imperfecta	3.3%
196	Pseudohypoparathyroidism	3.3%
197	Mitochondrial Encephalomyopathies	3.3%
198	Welander Distal Myopathy	3.3%
199	Cleft Palate	3.3%
200	Mastoiditis	3.2%
201	Petrositis	3.2%
202	Noonan Syndrome	2.9%
203	Dermatomyositis	2.8%
204	Muscular Dystrophy, Duchenne	2.7%
205	Osteomalacia	2.7%
206	Porencephaly	2.7%
207	Marfan Syndrome	2.6%
208	Holoprosencephaly	2.6%
209	Cockayne Syndrome	2.1%
210	Nose Neoplasms	1.9%
211	Radicular Cyst	1.8%
212	Renal Osteodystrophy	1.8%
213	Renal rickets	1.8%
214	MELAS Syndrome	1.5%
215	Kearns-Sayre syndrome	1.3%
216	Familial Hypophosphatemic Rickets	0.9%

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