MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteogenesis Imperfecta

(UMLS:C0029434)

Definition:: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
UMLS ID:: C0029434
MeSH ID:: D010013

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.708.685

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.737

Classification 3:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.200.540

Synonym(s)

Osteogenesis Imperfecta

Brittle bone disease

Brittle bone syndrome

Fragilitas ossium

OI - Osteogenesis imperfecta

OSTEOGENESIS IMPERFECTA

OSTEOPSATHYROSIS

Osteogenesis imperfecta

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 61	US FAERS
2	Alendronate	FAERS: 14	SIDER US FAERS
3	Rosiglitazone	FAERS: 11	OFFSIDES US FAERS
4	Zoledronic Acid	FAERS: 7	OFFSIDES US FAERS
5	Esomeprazole	FAERS: 6	US FAERS
6	Teriparatide	FAERS: 6	US FAERS
7	Medroxyprogesterone Acetate	FAERS: 4	US FAERS
8	Venlafaxine Hydrochloride	FAERS: 4 Canada Vigilance: 1	Canada Vigilance US FAERS
9	Lenalidomide	FAERS: 3	US FAERS
10	Prednisolone	FAERS: 3	US FAERS
11	Thalidomide	FAERS: 3	US FAERS
12	Varenicline	FAERS: 3	US FAERS
13	palbociclib	FAERS: 3	US FAERS
14	Fluticasone-Salmeterol Drug Combination	FAERS: 2	US FAERS
15	Omeprazole	FAERS: 2	US FAERS
16	Pamidronate	FAERS: 2	US FAERS
17	exemestane	FAERS: 2	US FAERS
18	lenvatinib	FAERS: 2	US FAERS
19	Celecoxib	FAERS: 1	US FAERS
20	Dronabinol	FAERS: 1	US FAERS
21	Erlotinib Hydrochloride	FAERS: 1	US FAERS
22	Fosamax plus D	FAERS: 1	US FAERS
23	Gabapentin	FAERS: 1	US FAERS
24	Glatiramer Acetate	FAERS: 1	US FAERS
25	Goserelin	FAERS: 1	US FAERS
26	Ibandronic Acid	FAERS: 1	US FAERS
27	Ibandronic Acid	FAERS: 1	OFFSIDES US FAERS
28	Lacosamide	FAERS: 1	US FAERS
29	Nexium 24hr	FAERS: 1	US FAERS
30	Paroxetine	FAERS: 1	US FAERS
31	Risedronic Acid	FAERS: 1	US FAERS
32	Rosiglitazone	FAERS: 1	US FAERS
33	Rosuvastatin Calcium	FAERS: 1	US FAERS
34	Sildenafil Citrate	FAERS: 1	OFFSIDES US FAERS
35	Sunitinib	FAERS: 1	US FAERS
36	Tacrolimus	FAERS: 1	US FAERS
37	Tenofovir	FAERS: 1	US FAERS
38	Triumeq	FAERS: 1	US FAERS
39	Valproic Acid	FAERS: 1	US FAERS
40	candesartan cilexetil	FAERS: 1	US FAERS
41	histrelin	FAERS: 1	US FAERS
42	sofosbuvir-velpatasvir drug combination	FAERS: 1	US FAERS
43	tofacitinib	FAERS: 1	US FAERS
44	Azathioprine		OFFSIDES
45	Bupropion		OFFSIDES
46	Loratadine		OFFSIDES
47	Lovastatin		OFFSIDES
48	Melatonin		OFFSIDES
49	Meperidine		OFFSIDES
50	Pamidronate		OFFSIDES
51	Pramipexole		OFFSIDES
52	Vitamin E		OFFSIDES
53	carbidopa, levodopa drug combination		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Dwarfism	26.3%
2	Chondrodysplasia Punctata	25%
3	Enchondromatosis	25%
4	Marfan Syndrome	25%
5	Osteosclerosis	25%
6	Kashin-Beck Disease	25%
7	Cutis Laxa	22.6%
8	Pectus carinatum	20.9%
9	Cockayne Syndrome	20.7%
10	Fragile X Syndrome	20.4%
11	Ichthyosis, X-Linked	19.8%
12	Mucopolysaccharidosis II	19.4%
13	Albinism	19.3%
14	Cartilage Diseases	19.1%
15	Rheumatism	19.1%
16	Chondromalacia	19.1%
17	Nail-Patella Syndrome	19%
18	Melorheostosis	18.7%
19	Osteopetrosis	18.7%
20	Aicardi's syndrome	18.4%
21	Osteochondritis	18.3%
22	Platybasia	18.1%
23	Pectus excavatum	18.1%
24	Muscular Dystrophy, Duchenne	18%
25	Dysostoses	17.6%
26	Congenital Hypothyroidism	17.2%
27	Rubinstein-Taybi Syndrome	17.2%
28	Anemia, Sickle Cell	17.1%
29	Thalassemia	17.1%
30	Neoplastic Syndromes, Hereditary	17%
31	CHARGE Syndrome	16.9%
32	Pseudoxanthoma Elasticum	16.8%
33	Beckwith-Wiedemann Syndrome	16.8%
34	Gigantism	16.8%
35	Wolf-Hirschhorn Syndrome	16.8%
36	Lupus Erythematosus, Cutaneous	16.6%
37	Panniculitis	16.6%
38	Systemic Scleroderma	16.6%
39	Morphea	16.6%
40	Rett Syndrome	16.4%
41	Multiple Epiphyseal Dysplasia	16.3%
42	Osteochondrodysplasias	16.3%
43	Pelger-Huet Anomaly	16.3%
44	Werner Syndrome	16.3%
45	Myasthenic Syndromes, Congenital	16.3%
46	Menkes Kinky Hair Syndrome	16%
47	Cystic Fibrosis	15.9%
48	Ectodermal Dysplasia	15.9%
49	Aplasia Cutis Congenita	15.9%
50	Alstrom Syndrome	15.9%
51	Keloid	15.5%
52	Mixed Connective Tissue Disease	15.4%
53	Mucinoses	15.4%
54	Homocystinuria	15.3%
55	Muscular Dystrophy	15.2%
56	Familial Mediterranean Fever	15.1%
57	Epidermolysis Bullosa	15.1%
58	Mucopolysaccharidosis III	14.6%
59	Porokeratosis	14.5%
60	Keratoderma, Palmoplantar	14.5%
61	Smith-Magenis syndrome	14.5%
62	Sjogren-Larsson Syndrome	14.3%
63	Cri-du-Chat Syndrome	14.3%
64	Down Syndrome	14.3%
65	Holoprosencephaly	14.3%
66	Trisomy 21	14.3%
67	Klippel-Feil Syndrome	14%
68	Synostosis	14%
69	Sickle Cell Trait	14%
70	Granuloma Annulare	13.9%
71	Necrobiosis Lipoidica Diabeticorum	13.8%
72	Osteoarthropathy, Secondary Hypertrophic	13.8%
73	Antley-Bixler Syndrome Phenotype	13.8%
74	Myotonic Dystrophy	13.6%
75	Panniculitis, Lupus Erythematosus	13.3%
76	Wiskott-Aldrich Syndrome	13.3%
77	Kartagener Syndrome	13.2%
78	Smith-Lemli-Opitz Syndrome	13.1%
79	Neuronal Ceroid-Lipofuscinoses	13%
80	Basal Cell Nevus Syndrome	12.9%
81	Hyperostosis	12.8%
82	Osteitis	12.8%
83	Osteitis Deformans	12.8%
84	Osteochondrosis	12.8%
85	Spinal Diseases	12.8%
86	Angioedemas, Hereditary	12.6%
87	Polymyalgia Rheumatica	12.6%
88	Dermatitis, Atopic	12.6%
89	Dermatomyositis	12.5%
90	Adrenoleukodystrophy	12.5%
91	Prader-Willi Syndrome	12.4%
92	Lupus Erythematosus, Systemic	12.4%
93	Overlap syndrome	12.4%
94	Xeroderma Pigmentosum	12.2%
95	Craniofacial Dysostosis	12.2%
96	Amino Acid Metabolism, Inborn Errors	12.1%
97	Carbohydrate Metabolism, Inborn Errors	12.1%
98	Metal Metabolism, Inborn Errors	12.1%
99	Progeria	12.1%
100	Lysosomal Storage Diseases	12.1%
101	Cytochrome-c Oxidase Deficiency	12.1%
102	Peroxisomal Disorders	12.1%
103	Fabry Disease	12%
104	Glycogen storage disease type II	11.9%
105	Hyperkeratosis, Epidermolytic	11.8%
106	Dupuytren Contracture	11.7%
107	Autoimmune Lymphoproliferative Syndrome	11.7%
108	Refsum Disease	11.6%
109	Primary Ciliary Dyskinesia	11.6%
110	Tietze's Syndrome	11.6%
111	Papillon-Lefevre Disease	11.5%
112	Noonan Syndrome	11.5%
113	Tuberous Sclerosis	11.5%
114	Polycystic Kidney Diseases	11.3%
115	Williams Syndrome	11.3%
116	Hepatolenticular Degeneration	11.3%
117	Acute Chest Syndrome	11.1%
118	Welander Distal Myopathy	11%
119	Craniosynostosis	10.9%
120	Syndactyly	10.9%
121	Brachycephaly	10.9%
122	Galactosemias	10.9%
123	Urea Cycle Disorders, Inborn	10.9%
124	Tyrosinemias	10.9%
125	Gout	10.9%
126	Amyloid Neuropathies, Familial	10.8%
127	Acrocephalosyndactylia	10.8%
128	Lupus Erythematosus, Discoid	10.7%
129	Scleroderma, Limited	10.7%
130	Bone Diseases, Endocrine	10.6%
131	Foot Diseases	10.6%
132	Xeroderma	10.6%
133	Porphyrias, Hepatic	10.6%
134	Deformity	10.6%
135	Kallmann Syndrome	10.5%
136	Arthrogryposis	10.3%
137	Bone Diseases, Infectious	10.3%
138	Bone neoplasms	10.3%
139	Osteopenia	10.3%
140	Retinal Dysplasia	10.3%
141	Aniridia	10.2%
142	Gaucher Disease	10.2%
143	Bone Resorption	10.2%
144	Aseptic Necrosis of Bone	10.2%
145	Retinitis Pigmentosa	10.1%
146	Pigmentary retinopathy	10.1%
147	Scleromyxedema	10.1%
148	Spinal Neoplasms	10.1%
149	Spondylitis	10.1%
150	Chronic granulomatous disease	10%
151	Myotonia Congenita	10%
152	Pseudohypoparathyroidism	10%
153	Alkaptonuria	9.9%
154	Glycogen Storage Disease	9.9%
155	Hypophosphatasia	9.9%
156	Propionic acidemia	9.9%
157	Dihydropyrimidine Dehydrogenase Deficiency	9.9%
158	Cystinosis	9.9%
159	Laryngomalacia	9.9%
160	Optic Atrophy, Hereditary, Leber	9.9%
161	Hyperphosphaturia	9.8%
162	Rheumatoid Arthritis	9.8%
163	Juvenile arthritis	9.8%
164	Tay-Sachs Disease	9.7%
165	Classical Lissencephalies and Subcortical Band Heterotopias	9.7%
166	Skin Abnormalities	9.7%
167	Peutz-Jeghers Syndrome	9.7%
168	Familial Periodic Paralysis	9.6%
169	Canavan Disease	9.4%
170	Alexander Disease	9.4%
171	Polycystic Kidney, Autosomal Dominant	9.3%
172	Leigh Disease	9.3%
173	Behcet Syndrome	9.3%
174	Zellweger Syndrome	9.1%
175	Niemann-Pick Disease, Type C	9.1%
176	Glycogen Storage Disease Type I	8.9%
177	Glycogen Storage Disease Type V	8.9%
178	Poland Syndrome	8.9%
179	Duane Retraction Syndrome	8.8%
180	Carbamoyl-Phosphate Synthase I Deficiency Disease	8.8%
181	Cellulitis	8.7%
182	Thrombasthenia	8.6%
183	Antithrombin III Deficiency	8.6%
184	Protein C Deficiency	8.6%
185	Brain Diseases, Metabolic, Inborn	8.6%
186	Afibrinogenemia	8.5%
187	Dystonia Musculorum Deformans	8.5%
188	Factor VII Deficiency	8.5%
189	Factor X Deficiency	8.5%
190	Factor XII Deficiency	8.5%
191	Hemophilia A	8.5%
192	Activated Protein C Resistance	8.5%
193	Factor II deficiency	8.5%
194	Factor VIII Deficiency	8.5%
195	Factor V deficiency	8.5%
196	Factor XI Deficiency	8.5%
197	Hypoprothrombinemias	8.5%
198	Fetal Diseases	8.5%
199	Fanconi Anemia	8.5%
200	Variegate Porphyria	8.5%
201	Acute intermittent porphyria	8.5%
202	Porphyria Cutanea Tarda	8.5%
203	Lafora Disease	8.5%
204	Unverricht-Lundborg Syndrome	8.5%
205	Anemia, Diamond-Blackfan	8.5%
206	Arthritis, Gouty	8.4%
207	Hypolipoproteinemias	8.2%
208	Hyperlipidemia, Familial Combined	8.2%
209	Charcot-Marie-Tooth Disease	8.2%
210	Hyperlipoproteinemia Type III	8.2%
211	Mesenteric Panniculitis	8.2%
212	Panniculitis, Peritoneal	8.2%
213	Orbital Cellulitis	8.2%
214	Myxoid cyst	8.2%
215	Ataxia Telangiectasia	8.1%
216	Bronchomalacia	8.1%
217	Tracheomalacia	8.1%
218	Myxedema	8.1%
219	Mandibulofacial Dysostosis	8%
220	Fasciitis	8%
221	Foot Deformities	8%
222	Arthropathy	8%
223	Goldenhar Syndrome	7.9%
224	Acrodermatitis	7.8%
225	Gianotti-Crosti Syndrome	7.8%
226	Hypokalemic periodic paralysis	7.7%
227	Rheumatoid Nodule	7.7%
228	Multiple Endocrine Neoplasia	7.7%
229	Ainhum	7.6%
230	Spinal Stenosis	7.6%
231	Spondylosis	7.6%
232	Intervertebral Disc Degeneration	7.6%
233	Limb Deformities, Congenital	7.5%
234	Craniofacial Abnormalities	7.5%
235	Erythema Induratum	7.4%
236	Hypoalphalipoproteinemias	7.4%
237	Klinefelter Syndrome	7.3%
238	Lactose Intolerance	7.1%
239	Hyperhomocysteinemia	7.1%
240	Renal Aminoacidurias	7%
241	Fanconi Syndrome	7%
242	Pseudohypoaldosteronism	7%
243	Liddle Syndrome	7%
244	Hyperlipoproteinemia Type IV	7%
245	Hyperlipoproteinemia Type V	7%
246	Contracture	6.9%
247	Fasciitis, Plantar	6.9%
248	Meconium Aspiration Syndrome	6.9%
249	Abdominal Cramps	6.8%
250	Abnormalities, Drug-Induced	6.8%
251	Amniotic Band Syndrome	6.8%
252	Asphyxia Neonatorum	6.8%
253	Infant, Premature, Diseases	6.8%
254	Situs Inversus	6.8%
255	Infantile Colic	6.8%
256	Mobius Syndrome	6.8%
257	Familial Hypophosphatemic Rickets	6.7%
258	Maxillofacial Abnormalities	6.7%
259	Pyoderma Gangrenosum	6.7%
260	Felty Syndrome	6.6%
261	Discitis	6.6%
262	Jaw Diseases	6.6%
263	Turner Syndrome	6.5%
264	Hydrops Fetalis	6.5%
265	Myopathy	6.4%
266	Cystinuria	6.3%
267	Eosinophilic Granuloma	6.2%
268	Multiple Endocrine Neoplasia Type 1	6.2%
269	Gastroschisis	6.2%
270	Friedreich Ataxia	6.2%
271	Jaw Abnormalities	6.1%
272	Renal tubular acidosis	6.1%
273	Anencephaly	6.1%
274	Osteomyelitis	6%
275	Osteoporosis	6%
276	Periostitis	6%
277	Bone Demineralization, Pathologic	6%
278	Post-Traumatic Osteoporosis	6%
279	Alveolar Bone Loss	6%
280	Femur Head Necrosis	6%
281	Osteolysis	6%
282	Huntington Disease	6%
283	Microcephaly	5.9%
284	Macrocephaly	5.9%
285	Rheumatoid Vasculitis	5.8%
286	Fibromyalgia	5.7%
287	Metatarsalgia	5.7%
288	Eye Abnormalities	5.7%
289	Cardiovascular Abnormalities	5.7%
290	Lupus Nephritis	5.7%
291	Tuberculosis, Spinal	5.6%
292	Talipes	5.5%
293	Lymphatic Abnormalities	5.5%
294	Congenital Microtia	5.5%
295	Anemia, Neonatal	5.4%
296	Persistent Fetal Circulation Syndrome	5.4%
297	Osteoarthritis, Spine	5.4%
298	Congenital diaphragmatic hernia	5.4%
299	Nephroblastoma	5.4%
300	Umbilical hernia	5.4%
301	Acne Vulgaris	5.4%
302	Contact Dermatitis	5.4%
303	Eczema	5.4%
304	Erythema Multiforme	5.4%
305	Intertrigo	5.4%
306	Neurodermatitis	5.4%
307	Rhinophyma	5.4%
308	Perioral Dermatitis	5.4%
309	Acne	5.4%
310	Amelia	5.3%
311	Arachnodactyly	5.3%
312	Ectromelia	5.3%
313	Hemimelia	5.3%
314	Phocomelia	5.3%
315	Sirenomelia	5.3%
316	Polydactyly	5.3%
317	Brachydactyly	5.3%
318	Plagiocephaly	5.3%
319	Lower Extremity Deformities, Congenital	5.3%
320	Upper Extremity Deformities, Congenital	5.3%
321	Dural Arteriovenous Fistula	5.3%
322	Arthritis, Psoriatic	5.3%
323	Dextrocardia	5.2%
324	Sicca Syndrome	5.1%
325	Sjogren's Syndrome	5.1%
326	Porencephaly	5.1%
327	Breast Diseases	5.1%
328	Dermatitis	5.1%
329	Exanthema	5.1%
330	Facial Dermatoses	5.1%
331	Hair Diseases	5.1%
332	Hand Dermatoses	5.1%
333	keratoacanthoma	5.1%
334	Keratosis	5.1%
335	Nail Diseases	5.1%
336	Photosensitivity Disorders	5.1%
337	Prurigo	5.1%
338	Pyoderma	5.1%
339	Rosacea	5.1%
340	Sebaceous Gland Diseases	5.1%
341	Skin Diseases, Vesiculobullous	5.1%
342	Skin Ulcer	5.1%
343	Sweat Gland Diseases	5.1%
344	Skin Diseases, Papulosquamous	5.1%
345	Skin Diseases, Vascular	5.1%
346	Acneiform Eruptions	5.1%
347	Ocular Rosacea	5.1%
348	Subcorneal pustular dermatosis	5.1%
349	Erythematotelangiectatic Rosacea	5.1%
350	Papulopustular Rosacea	5.1%
351	Chronic Actinic Dermatitis	5.1%
352	Prune Belly Syndrome	5%
353	Twins, Conjoined	5%
354	Waardenburg Syndrome	5%
355	Lordosis	5%
356	Spondylolysis	5%
357	kyphosis	5%
358	Cleft Palate	5%
359	Acromegaly	5%
360	Joint Tuberculosis	5%
361	Tuberculosis, Osteoarticular	5%
362	Bone Tuberculosis	5%
363	Dermatitis, Phototoxic	4.9%
364	Pityriasis Lichenoides et Varioliformis Acuta	4.9%
365	Pityriasis Lichenoides	4.9%
366	Phototoxicity	4.9%
367	Adenomatous Polyposis Coli	4.9%
368	Glycosuria, Renal	4.9%
369	Prognathism	4.9%
370	Micrognathism	4.8%
371	Pierre Robin Syndrome	4.8%
372	Urogenital Abnormalities	4.7%
373	Foot Ulcer	4.7%
374	Neonatal Abstinence Syndrome	4.6%
375	MELAS Syndrome	4.6%
376	Ankylosing spondylitis	4.5%
377	Dermatitis Herpetiformis	4.5%
378	Fetal Growth Retardation	4.5%
379	Rheumatic Fever	4.5%
380	Fetal Hypoxia	4.5%
381	Congenital nystagmus	4.5%
382	Fetal Alcohol Spectrum Disorders	4.5%
383	Sebaceous Gland Neoplasms	4.5%
384	Toxoplasmosis, Congenital	4.5%
385	Syphilis, Congenital	4.4%
386	CREST Syndrome	4.4%
387	Congenital clubfoot	4.4%
388	Vertical Talus	4.4%
389	Retrognathia	4.3%
390	Ischemic contracture	4.3%
391	Temporomandibular Joint Disorders	4.3%
392	Spondylarthropathies	4.3%
393	Arthritis	4.3%
394	Bursitis	4.3%
395	Joint Instability	4.3%
396	Myofascial Pain Syndromes	4.3%
397	Rhabdomyolysis	4.3%
398	Synovitis	4.3%
399	Joint laxity	4.3%
400	Polyarthritis	4.3%
401	Frozen shoulder	4.3%
402	Patellofemoral Pain Syndrome	4.3%
403	Rickets	4.3%
404	Dermatitis, Photoallergic	4.2%
405	Denys-Drash Syndrome	4.2%
406	Scimitar Syndrome	4.2%
407	Skin Diseases, Infectious	4.1%
408	Skin Neoplasms	4.1%
409	Pigmentation Disorders	4.1%
410	Anophthalmos	4.1%
411	Anus, Imperforate	4.1%
412	Hydranencephaly	4.1%
413	Lipomatosis	4.1%
414	Microphthalmos	4.1%
415	Neural Tube Defects	4.1%
416	Paralysis, Obstetric	4.1%
417	Pruritus	4.1%
418	Retinopathy of Prematurity	4.1%
419	Erythema	4.1%
420	Tethered Cord Syndrome	4.1%
421	Iniencephaly	4.1%
422	Craniorachischisis	4.1%
423	Necrolytic Migratory Erythema	4.1%
424	Exencephaly	4.1%
425	Septo-Optic Dysplasia	4.1%
426	Cutaneous Fistula	4.1%
427	Cortical Dysplasia	4.1%
428	Nephrogenic Fibrosing Dermopathy	4.1%
429	Malformations of Cortical Development	4.1%
430	Anorectal Malformations	4.1%
431	Nephrogenic Systemic Fibrosis	4.1%
432	Bloom Syndrome	4%
433	Hip Contracture	4%
434	Periarthritis	4%
435	Bronchopulmonary Dysplasia	4%
436	Osteoporosis, Postmenopausal	4%
437	Dermatitis, Irritant	4%
438	Acne Conglobata	4%
439	Congenital Hyperinsulinism	3.9%
440	Urticaria Pigmentosa	3.9%
441	Chorioamnionitis	3.8%
442	Spondylolisthesis	3.7%
443	Temporomandibular Joint Dysfunction Syndrome	3.5%
444	Compartment syndromes	3.4%
445	Maxillary Diseases	3.4%
446	Tendinitis	3.4%
447	Tendinopathy	3.4%
448	Blepharophimosis	3.4%
449	Laryngostenosis	3.4%
450	Mouth Abnormalities	3.4%
451	Dermatitis, Occupational	3.4%
452	Respiratory Distress Syndrome, Newborn	3.4%
453	Hemarthrosis	3.4%
454	Myositis	3.4%
455	Isaacs syndrome	3.4%
456	Myotonic Disorders	3.4%
457	Arthritis, Reactive	3.4%
458	Esophageal Atresia	3.4%
459	Intestinal Atresia	3.4%
460	Horseshoe Kidney	3.4%
461	Mastocytosis	3.4%
462	Erythema Infectiosum	3.4%
463	Anhidrosis	3.4%
464	Cholesteatoma	3.4%
465	Pressure Ulcer	3.4%
466	Folliculitis	3.4%
467	Foot Dermatoses	3.4%
468	Gynecomastia	3.4%
469	Hypertrichosis	3.4%
470	Hypohidrosis	3.4%
471	Hypotrichosis	3.4%
472	Leg Ulcer	3.4%
473	Miliaria	3.4%
474	Parakeratosis	3.4%
475	Parapsoriasis	3.4%
476	Pityriasis	3.4%
477	Psoriasis	3.4%
478	Sweet Syndrome	3.4%
479	Hidradenitis	3.4%
480	Onycholysis	3.4%
481	Miliaria Rubra	3.4%
482	Hyperpigmentation	3.4%
483	Lichenoid Eruptions	3.4%
484	Chloracne	3.4%
485	Lymphangiectasis, Intestinal	3.4%
486	Exanthema Subitum	3.3%
487	Abnormalities, Radiation-Induced	3.3%
488	Ectopia Cordis	3.3%
489	Meningomyelocele	3.3%
490	Spina Bifida	3.3%
491	Osteoarthritis, Knee	3.3%
492	Single umbilical artery	3.3%
493	Dermatitis, Allergic Contact	3.3%
494	Erythema Nodosum	3.3%
495	Mastoiditis	3.3%
496	Petrositis	3.3%
497	Diaper Rash	3.3%
498	Toxic Epidermal Necrolysis	3.3%
499	Stevens-Johnson Syndrome	3.3%
500	Tinea Capitis	3.1%
501	Onychomycosis	3.1%
502	Dermal Sinus	3%
503	Spina Bifida Cystica	3%
504	Spina Bifida Occulta	3%
505	Lissencephaly	3%
506	Polymicrogyria	3%
507	Pachygyria	3%
508	Schizencephaly	3%
509	Periventricular Nodular Heterotopia	3%
510	Choanal Atresia	3%
511	Tracheobronchomegaly	3%
512	Laryngocele	3%
513	Ophthalmia Neonatorum	2.9%
514	Choledochal Cyst	2.9%
515	Hermaphroditism	2.9%
516	Disorders of Sex Development	2.9%
517	Cryptorchidism	2.9%
518	Hypospadias	2.9%
519	Ecthyma	2.9%
520	Central Nervous System Cysts	2.9%
521	Dandy-Walker Syndrome	2.9%
522	Medial Tibial Stress Syndrome	2.9%
523	Leukomalacia, Periventricular	2.8%
524	POEMS Syndrome	2.8%
525	Nesidioblastosis	2.8%
526	Mitochondrial Myopathies	2.8%
527	Muscle Cramp	2.8%
528	Eosinophilia-Myalgia Syndrome	2.8%
529	Osteomalacia	2.8%
530	Lupus Vasculitis, Central Nervous System	2.8%
531	Muscle Rigidity	2.8%
532	Muscle Spasticity	2.8%
533	Cogwheel Rigidity	2.8%
534	Nuchal Rigidity	2.8%
535	Aortic coarctation	2.8%
536	Cor Triatriatum	2.8%
537	Coronary Vessel Anomalies	2.8%
538	Dental Enamel Hypoplasia	2.8%
539	Patent ductus arteriosus	2.8%
540	Ebstein Anomaly	2.8%
541	Heart Septal Defects	2.8%
542	Hyaline Membrane Disease	2.8%
543	Hypodontia	2.8%
544	Macrostomia	2.8%
545	Meningocele	2.8%
546	Microstomia	2.8%
547	Tetralogy of Fallot	2.8%
548	Transposition of Great Vessels	2.8%
549	Hypoplastic Left Heart Syndrome	2.8%
550	May-Thurner Syndrome	2.8%
551	Encephalocele	2.8%
552	Palatal Neoplasms	2.7%
553	Wolff-Parkinson-White Syndrome	2.7%
554	Acantholysis	2.7%
555	Breast Cyst	2.7%
556	Actinic keratosis	2.7%
557	Pemphigoid, Benign Mucous Membrane	2.7%
558	Pemphigus	2.7%
559	Piedra	2.7%
560	Sunburn	2.7%
561	Argyria	2.7%
562	Hirsutism	2.7%
563	Lactation Disorder	2.7%
564	Mastitis	2.7%
565	Urticaria	2.7%
566	Adiposis Dolorosa	2.7%
567	Pruritus Vulvae	2.7%
568	Mastocytoma	2.7%
569	Pruritus Ani	2.7%
570	Hyperandrogenism	2.7%
571	Bladder Exstrophy	2.5%
572	Bunion	2.5%
573	Epispadias	2.5%
574	Fibrodysplasia Ossificans Progressiva	2.5%
575	Myoglobinuria	2.5%
576	Myositis Ossificans	2.5%
577	Tenosynovitis	2.5%
578	Sacroiliitis	2.5%
579	Chronic Fatigue Syndrome	2.5%
580	Multicystic Dysplastic Kidney	2.5%
581	Lichen Planus	2.5%
582	Melanosis	2.5%
583	Chloasma	2.5%
584	Pityriasis Rosea	2.5%
585	Pityriasis Rubra Pilaris	2.5%
586	Vitiligo	2.5%
587	Lichen Nitidus	2.5%
588	Hidradenitis Suppurativa	2.5%
589	Aortopulmonary Septal Defect	2.5%
590	Double Outlet Right Ventricle	2.5%
591	Endocardial Cushion Defects	2.5%
592	Myocardial bridging	2.5%
593	Aorticopulmonary Septal Defect	2.5%
594	Giant Cell Epulis	2.4%
595	Muscle Weakness	2.4%
596	Musculoskeletal Pain	2.4%
597	Arthralgia	2.4%
598	Long QT Syndrome	2.4%
599	Polyarthralgia	2.4%
600	Tricuspid Atresia	2.4%
601	Arrhythmogenic Right Ventricular Dysplasia	2.4%
602	Gonadal Dysgenesis	2.4%
603	Adrenogenital Syndrome	2.4%
604	Ovotesticular Disorders of Sex Development	2.4%
605	Truncus Arteriosus, Persistent	2.3%
606	Erythema Chronicum Migrans	2.3%
607	Dermatomycoses	2.3%
608	Mucocutaneous Lymph Node Syndrome	2.3%
609	Skin Diseases, Bacterial	2.3%
610	Tinea Pedis	2.2%
611	Kernicterus	2.2%
612	Drug Eruptions	2.2%
613	Lipodystrophy	2.2%
614	Livedo Reticularis	2.2%
615	Malignant Atrophic Papulosis	2.2%
616	Polyarteritis Nodosa	2.2%
617	Takayasu Arteritis	2.2%
618	Romano-Ward Syndrome	2.1%
619	Myalgia	2.1%
620	Acanthosis Nigricans	2.1%
621	Alopecia Areata	2.1%
622	Lentigo	2.1%
623	Arthritis, Infectious	2%
624	Nose Neoplasms	2%
625	Alopecia	2%
626	Sweating, Gustatory	2%
627	Androgenetic Alopecia	2%
628	Auriculotemporal Syndrome	2%
629	Anterior Compartment Syndrome	2%
630	Enthesopathy	2%
631	Arthritis, Experimental	2%
632	Abdominal Compartment Syndrome	2%
633	Lice Infestations	2%
634	Varicose Ulcer	2%
635	Polymyositis	2%
636	Breast Neoplasms, Male	2%
637	Triple Negative Breast Neoplasms	2%
638	Galactorrhea	2%
639	Mycetoma	2%
640	Renal Osteodystrophy	2%
641	Renal rickets	2%
642	Hip Dislocation	1.7%
643	Shoulder Dislocation	1.7%
644	Hip Dysplasia	1.7%
645	Larva Migrans	1.7%
646	Leishmaniasis	1.7%
647	Molluscum Contagiosum	1.7%
648	Orbital Myositis	1.7%
649	Lichen Planus, Oral	1.7%
650	Angioedema	1.7%
651	Onchocerciasis	1.7%
652	Pyomyositis	1.7%
653	Chromoblastomycosis	1.7%
654	Dermatophytosis	1.7%
655	Sporotrichosis	1.7%
656	Tinea	1.7%
657	Tinea Versicolor	1.7%
658	Trichophytosis	1.7%
659	Hyalohyphomycosis	1.7%
660	Acute Generalized Exanthematous Pustulosis	1.6%
661	Arteriovenous fistula	1.6%
662	Warts	1.5%
663	Candidiasis, Chronic Mucocutaneous	1.4%
664	Cutaneous Candidiasis	1.4%
665	Erysipelas	1.4%
666	Serum Sickness	1.4%
667	Staphylococcal Skin Infections	1.4%
668	Erythrasma	1.4%
669	Carcinoma, Lobular	1.4%
670	Shoulder Pain	1.4%
671	Leishmaniasis, Cutaneous	1.4%
672	Eczema Herpeticum	1.4%
673	Fusariosis	1.4%
674	Giant Cell Arteritis	1.3%
675	Temporal Arteritis	1.3%
676	Mitochondrial Encephalomyopathies	1.2%
677	Hereditary Angioedema Type III	1.2%
678	Hereditary Angioedema Types I and II	1.2%
679	Epidermodysplasia Verruciformis	1.2%
680	Herpes Labialis	1.2%
681	Diabetic Foot	1.2%
682	Staphylococcal Scalded Skin Syndrome	1.2%
683	Blastomycosis	1.1%
684	HIV-Associated Lipodystrophy Syndrome	1.1%
685	carbuncle	1%
686	Condylomata Acuminata	1%
687	Furunculosis	1%
688	furuncle	1%
689	Impetigo	1%
690	Rhinoscleroma	1%
691	Radicular Cyst	0.6%
692	Kearns-Sayre syndrome	0.5%

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