MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cleft Palate

(UMLS:C0008925)

Definition:: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
UMLS ID:: C0008925
MeSH ID:: D002972

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.500.460.185|C05.660.207.540.460.185

Classification 2:

Name:

Stomatognathic Diseases
MeSH Tree Number(s):: C07.320.440.185|C07.465.525.185|C07.650.500.460.185|C07.650.525.185

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.207.540.460.185|C16.131.850.500.460.185|C16.131.850.525.185

Synonym(s)

Cleft Palate

CLEFT PALATE

CP - Cleft palate

Cleft palate

Cleft palate, NOS

Cleft palate, unspecified

PALATE CLEFT

Palatoschisis

Uranoschisis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ondansetron	FAERS: 121		US FAERS
2	Paroxetine	FAERS: 118		US FAERS
3	Fluoxetine	FAERS: 85		US FAERS
4	Sertraline	FAERS: 75		US FAERS
5	Lamotrigine	FAERS: 45		OFFSIDES US FAERS
6	Topiramate	FAERS: 30		US FAERS
7	Valproic Acid	FAERS: 25		US FAERS
8	Isotretinoin	FAERS: 19	3162101	CTD US FAERS
9	Valproic Acid	FAERS: 17		US FAERS
10	Valproic Acid	FAERS: 14	View details 2284927 2492459 3142446 15794725	CTD US FAERS
11	Metformin	FAERS: 12		US FAERS
12	Venlafaxine Hydrochloride	FAERS: 11 Canada Vigilance: 2		Canada Vigilance US FAERS
13	Citalopram	FAERS: 10		US FAERS
14	Citalopram	FAERS: 10		OFFSIDES US FAERS
15	Citalopram	FAERS: 8		US FAERS
16	Levetiracetam	FAERS: 8		US FAERS
17	Dexamethasone	FAERS: 7		US FAERS
18	Methotrexate	FAERS: 7	16470853	CTD US FAERS
19	Mycophenolic Acid	FAERS: 5		US FAERS
20	Norgestrel	FAERS: 5		US FAERS
21	Quetiapine Fumarate	FAERS: 5		US FAERS
22	Buprenorphine	FAERS: 4		OFFSIDES US FAERS
23	Naproxen	FAERS: 4	11489592	CTD US FAERS
24	Paroxetine	FAERS: 4 Canada Vigilance: 6		Canada Vigilance US FAERS
25	17 alpha-Hydroxyprogesterone Caproate	FAERS: 3		US FAERS
26	Cabergoline	FAERS: 3		US FAERS
27	Carbamazepine	FAERS: 3 Canada Vigilance: 1	2492459	CTD Canada Vigilance US FAERS
28	Diazepam	FAERS: 3	3629520	CTD US FAERS
29	Fentanyl	FAERS: 3		US FAERS
30	Olanzapine	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
31	Phenytoin	FAERS: 3	View details 56626 940034 1687470 2227380 2492459 3877104 4441320 6856622 6862529 7946029 10789828 11283972	CTD US FAERS
32	Tramadol	FAERS: 3		US FAERS
33	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 2		US FAERS
34	Acetaminophen	FAERS: 2		US FAERS
35	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 2		US FAERS
36	Atorvastatin	FAERS: 2		US FAERS
37	Cetirizine	FAERS: 2		US FAERS
38	Dimethyl Fumarate	FAERS: 2		US FAERS
39	Duloxetine Hydrochloride	FAERS: 2		US FAERS
40	Fluconazole	FAERS: 2 Canada Vigilance: 2	16781842	CTD Canada Vigilance US FAERS
41	Fluoxetine	FAERS: 2		US FAERS
42	Insulin Glargine	FAERS: 2		US FAERS
43	Lamivudine	FAERS: 2		US FAERS
44	Nifedipine	FAERS: 2		US FAERS
45	Norfloxacin	FAERS: 2		OFFSIDES US FAERS
46	Omeprazole	FAERS: 2		US FAERS
47	Ranitidine	FAERS: 2		US FAERS
48	Sertraline	FAERS: 2		OFFSIDES US FAERS
49	Simvastatin	FAERS: 2		US FAERS
50	Thyroxine	FAERS: 2		US FAERS
51	Zidovudine	FAERS: 2		US FAERS
52	Albendazole	FAERS: 1		US FAERS
53	Albuterol	FAERS: 1		US FAERS
54	Alprazolam	FAERS: 1		US FAERS
55	Atorvastatin	FAERS: 1		US FAERS
56	Azathioprine	FAERS: 1		US FAERS
57	Budesonide	FAERS: 1		OFFSIDES US FAERS
58	Bupropion	FAERS: 1		US FAERS
59	Capecitabine	FAERS: 1		US FAERS
60	Cefuroxime	FAERS: 1		US FAERS
61	Cetirizine	FAERS: 1		US FAERS
62	Doxycycline hydrochloride	FAERS: 1		US FAERS
63	Furosemide	FAERS: 1		US FAERS
64	Glatiramer Acetate	FAERS: 1		US FAERS
65	Ibuprofen	FAERS: 1		US FAERS
66	Imipramine	FAERS: 1		US FAERS
67	Leflunomide	FAERS: 1	17604599	CTD US FAERS
68	Lisinopril	FAERS: 1		US FAERS
69	Lorazepam	FAERS: 1		US FAERS
70	Mebendazole	FAERS: 1		US FAERS
71	Medroxyprogesterone Acetate	FAERS: 1	6461082	CTD US FAERS
72	Mesalamine	FAERS: 1		US FAERS
73	Metformin	FAERS: 1		US FAERS
74	Methadone	FAERS: 1		US FAERS
75	Methadone	FAERS: 1		US FAERS
76	Methotrexate	FAERS: 1		US FAERS
77	Mirtazapine	FAERS: 1		US FAERS
78	Modafinil	FAERS: 1		US FAERS
79	Nafarelin	FAERS: 1		US FAERS
80	Naproxen	FAERS: 1		US FAERS
81	Nicotine	FAERS: 1		US FAERS
82	Nitrofurantoin	FAERS: 1	19884587	CTD OFFSIDES US FAERS
83	Ondansetron	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
84	Ortho Evra	FAERS: 1		US FAERS
85	Oxcarbazepine	FAERS: 1		US FAERS
86	Penicillamine	FAERS: 1		OFFSIDES US FAERS
87	Prednisolone	FAERS: 1		US FAERS
88	Prednisone	FAERS: 1	19479239	CTD US FAERS
89	Pregabalin	FAERS: 1		US FAERS
90	Progesterone	FAERS: 1		SIDER US FAERS
91	Promethazine	FAERS: 1		US FAERS
92	Risperidone	FAERS: 1		US FAERS
93	Sumatriptan	FAERS: 1		US FAERS
94	Tacrolimus	FAERS: 1		US FAERS
95	Tamoxifen	FAERS: 1		US FAERS
96	Tamoxifen	FAERS: 1		OFFSIDES US FAERS
97	Telbivudine	FAERS: 1		US FAERS
98	Tenofovir	FAERS: 1		US FAERS
99	Tramadol	FAERS: 1		US FAERS
100	Valacyclovir	FAERS: 1		US FAERS
101	brivaracetam	FAERS: 1		US FAERS
102	norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination	FAERS: 1		US FAERS
103	ropinirole	FAERS: 1		OFFSIDES US FAERS
104	sibutramine	FAERS: 1		US FAERS
105	2-amino-1,3,4-thiadiazole		4269736	CTD
106	6-Aminonicotinamide		2227380 15826874	CTD
107	Acamprosate			OFFSIDES
108	Acetazolamide			OFFSIDES
109	Alcohols		15513904	CTD
110	Aminopropionitrile		9200351	CTD
111	Atomoxetine Hydrochloride			OFFSIDES
112	Betamethasone Valerate			OFFSIDES
113	Brimonidine Tartrate			OFFSIDES
114	Caffeine			OFFSIDES
115	Captopril	Canada Vigilance: 1		Canada Vigilance
116	Clobazam			OFFSIDES
117	Clomiphene			SIDER
118	Clomiphene			OFFSIDES
119	Cocaine		12854855	CTD
120	Cyclamates	Canada Vigilance: 1		Canada Vigilance
121	Cyclophosphamide		19851987	CTD
122	Cyproterone Acetate		6461082	CTD
123	Decitabine		27915011 27923600	CTD
124	Dimethadione		12027905	CTD
125	Erythromycin			OFFSIDES
126	Esomeprazole	Canada Vigilance: 1		Canada Vigilance
127	Fluorouracil		9299594	CTD
128	Folic Acid		8946559 21254359	CTD OFFSIDES
129	Ganciclovir			OFFSIDES
130	Hydrocortisone		10048155 15826874	CTD
131	Ketamine			OFFSIDES
132	Ketoconazole		19479239 28263823	CTD
133	Medroxyprogesterone			SIDER
134	Methanol		8946559 23207165	CTD
135	Nelfinavir			OFFSIDES
136	Niacinamide		4269736	CTD
137	Niacin		14991264	CTD
138	Nystatin			OFFSIDES
139	Omeprazole	Canada Vigilance: 2		Canada Vigilance
140	Phenobarbital		2492459	CTD
141	Piperonyl Butoxide		19851987	CTD
142	Polychlorinated Dibenzodioxins		View details 2260090 2718176 2734791 2763295 2998748 7864861 8697196 10048155 10048156 11091363 11399798 12520078 12621046 15340226 15668235 16354765 16545771 21807577 27163630 27284320 29043426	CTD
143	Primidone		2492459	CTD OFFSIDES
144	Prochlorperazine	Canada Vigilance: 1		Canada Vigilance
145	Pyran Copolymer		11091363	CTD
146	Pyridoxine		14991264	CTD
147	Salicylate	Canada Vigilance: 1		Canada Vigilance
148	Salmeterol Xinafoate			OFFSIDES
149	Sirolimus			OFFSIDES
150	Sumatriptan			OFFSIDES
151	Tenofovir			OFFSIDES
152	Thiamine		14991264	CTD
153	Thiethylperazine		12742335	CTD
154	Tretinoin		View details 2260090 2718176 7864861 9407595 9535508 21807577	CTD OFFSIDES
155	Triamcinolone		2998748	CTD SIDER
156	Urethane		11091363 12810352	CTD
157	Vitamin A		16054864	CTD
158	Vitamin K 1			OFFSIDES
159	bis(tri-n-butyltin)oxide		3108662	CTD
160	bitertanol		16781842	CTD
161	chlorcyclizine		21058326	CTD
162	chloroquine diphosphate	Canada Vigilance: 1		Canada Vigilance
163	cyclopamine		18411234	CTD
164	cyproconazole		16781842	CTD
165	di-n-hexyl phthalate		19391110	CTD
166	difluprednate			SIDER
167	efavirenz			SIDER
168	ferrous fumarate			OFFSIDES
169	flusilazole		16781842 28263823	CTD
170	geranylgeranylacetone		15340226	CTD
171	mepronizine			OFFSIDES
172	perfluorooctane sulfonic acid		19041924	CTD
173	phenyl-N-tert-butylnitrone		12027905	CTD
174	telmisartan, hydrochlorothiazide drug combination			OFFSIDES
175	triadimefon		16781842 28263823	CTD
176	triphenyltin hydroxide		17619067	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Retrognathia	51.2%
2	Prognathism	51.1%
3	Micrognathism	49.6%
4	Pierre Robin Syndrome	49.6%
5	Macrostomia	34.9%
6	Microstomia	34.9%
7	Holoprosencephaly	24.4%
8	Rubinstein-Taybi Syndrome	22.4%
9	Temporomandibular Joint Disorders	19.8%
10	Craniosynostosis	19.8%
11	Brachycephaly	19.8%
12	Dental Enamel Hypoplasia	19.6%
13	Hypodontia	19.6%
14	Giant Cell Epulis	18.9%
15	Mouth Abnormalities	18.8%
16	Arthrogryposis	18.6%
17	Maxillofacial Abnormalities	18.3%
18	Maxillary Diseases	17.3%
19	Acrocephalosyndactylia	16.8%
20	Cleft Palate	16.6%
21	Pectus carinatum	16.3%
22	Platybasia	16%
23	Pectus excavatum	16%
24	Facial Hemiatrophy	15.9%
25	Melkersson-Rosenthal Syndrome	15.9%
26	Aicardi's syndrome	15.6%
27	Limb Deformities, Congenital	15.5%
28	Klippel-Feil Syndrome	15.4%
29	Synostosis	15.4%
30	Jaw Abnormalities	15.3%
31	Mobius Syndrome	15.2%
32	Microcephaly	15.1%
33	Macrocephaly	15.1%
34	Syndactyly	15.1%
35	Plagiocephaly	15%
36	Craniofacial Dysostosis	15%
37	Beckwith-Wiedemann Syndrome	14.8%
38	Wolf-Hirschhorn Syndrome	14.8%
39	Bell Palsy	14.7%
40	Radicular Cyst	14.5%
41	Noonan Syndrome	14.2%
42	Gastroschisis	14.1%
43	Palatal Neoplasms	13.9%
44	Smith-Magenis syndrome	13.7%
45	Tooth Loss	13.7%
46	Temporomandibular Joint Dysfunction Syndrome	13.7%
47	Cri-du-Chat Syndrome	13.6%
48	Down Syndrome	13.6%
49	Trisomy 21	13.6%
50	Abnormalities, Drug-Induced	13.5%
51	Situs Inversus	13.5%
52	Tooth Diseases	13%
53	Ectodermal Dysplasia	12.7%
54	Aplasia Cutis Congenita	12.7%
55	Parotid Neoplasms	12.7%
56	Prader-Willi Syndrome	12.7%
57	Eye Abnormalities	12.5%
58	Cardiovascular Abnormalities	12.5%
59	Salivary Gland Fistula	12.5%
60	Salivary Gland Neoplasms	12.5%
61	Tongue Neoplasms	12.5%
62	Skin Abnormalities	12.4%
63	Lymphatic Abnormalities	12.4%
64	Congenital Microtia	12.4%
65	Congenital diaphragmatic hernia	12.3%
66	Nail-Patella Syndrome	12.1%
67	Pharyngeal Diseases	12%
68	Marfan Syndrome	11.9%
69	Kartagener Syndrome	11.9%
70	Basal Cell Nevus Syndrome	11.8%
71	Urogenital Abnormalities	11.6%
72	Jaw Diseases	11.5%
73	Burning Mouth Syndrome	11.5%
74	Lip Diseases	11.5%
75	Microglossia	11.5%
76	Oral Submucous Fibrosis	11.5%
77	Periodontal Diseases	11.5%
78	Salivary Gland Diseases	11.5%
79	Stomatitis	11.5%
80	Tongue Diseases	11.5%
81	Oral Ulcer	11.5%
82	Gingival Hemorrhage	10.8%
83	Facial Nerve Diseases	10.5%
84	Granulomatosis, Orofacial	10.5%
85	Oral candidiasis	10.5%
86	Mouth Neoplasms	10.5%
87	Oral Fistula	10.5%
88	Porencephaly	10.5%
89	Lichen Planus, Oral	10.4%
90	Anencephaly	10.2%
91	Laryngomalacia	10.2%
92	CHARGE Syndrome	10.1%
93	Gingival Recession	10%
94	Parotitis	10%
95	Gingival Atrophy	10%
96	Poland Syndrome	10%
97	Abnormalities, Radiation-Induced	9.7%
98	Mouth Diseases	9.6%
99	Facial paralysis	9.6%
100	Facial Paresis	9.6%
101	Hemifacial Spasm	9.5%
102	Dural Arteriovenous Fistula	9.5%
103	Cockayne Syndrome	9.4%
104	Dextrocardia	9.4%
105	Xeroderma	9.4%
106	Behcet Syndrome	9.3%
107	Amelia	9.1%
108	Arachnodactyly	9.1%
109	Ectromelia	9.1%
110	Hemimelia	9.1%
111	Phocomelia	9.1%
112	Sirenomelia	9.1%
113	Polydactyly	9.1%
114	Brachydactyly	9.1%
115	Lower Extremity Deformities, Congenital	9.1%
116	Upper Extremity Deformities, Congenital	9.1%
117	Antley-Bixler Syndrome Phenotype	9%
118	Mandibulofacial Dysostosis	8.9%
119	Genetic Diseases, Inborn	8.6%
120	Scimitar Syndrome	8.3%
121	Alstrom Syndrome	8.3%
122	Fetal Diseases	7.8%
123	Polycystic Kidney Diseases	7.8%
124	Williams Syndrome	7.8%
125	Ichthyosis, X-Linked	7.7%
126	Prune Belly Syndrome	7.6%
127	Twins, Conjoined	7.6%
128	Waardenburg Syndrome	7.6%
129	Bruxism	7.5%
130	Dental Leakage	7.5%
131	Hypercementosis	7.5%
132	Malocclusion	7.5%
133	Tooth Crowding	7.5%
134	Tooth Discoloration	7.5%
135	Tooth Demineralization	7.5%
136	Tooth Ankylosis	7.5%
137	Cheilitis	7.5%
138	Drooling	7.5%
139	Gingival Diseases	7.5%
140	Glossitis	7.5%
141	Macroglossia	7.5%
142	Periodontitis	7.5%
143	Sialadenitis	7.5%
144	Sialometaplasia, Necrotizing	7.5%
145	Sialorrhea	7.5%
146	Aphthous Stomatitis	7.5%
147	Xerostomia	7.5%
148	Glossoptosis	7.5%
149	Peri-Implantitis	7.5%
150	Retinal Dysplasia	7.4%
151	Aniridia	7.3%
152	Epidermolysis Bullosa	7.3%
153	Smith-Lemli-Opitz Syndrome	7.1%
154	Cystic Fibrosis	7.1%
155	Nasopharyngitis	7%
156	Talipes	7%
157	Tooth Injuries	7%
158	Goldenhar Syndrome	7%
159	Alveolar Bone Loss	7%
160	Anophthalmos	6.9%
161	Anus, Imperforate	6.9%
162	Hydranencephaly	6.9%
163	Microphthalmos	6.9%
164	Neural Tube Defects	6.9%
165	Tethered Cord Syndrome	6.9%
166	Iniencephaly	6.9%
167	Craniorachischisis	6.9%
168	Exencephaly	6.9%
169	Septo-Optic Dysplasia	6.9%
170	Cortical Dysplasia	6.9%
171	Malformations of Cortical Development	6.9%
172	Anorectal Malformations	6.9%
173	Tooth Resorption	6.9%
174	Bloom Syndrome	6.9%
175	Turner Syndrome	6.9%
176	Toothache	6.8%
177	Facial Neuralgia	6.8%
178	Dental Fistula	6.8%
179	Oroantral Fistula	6.8%
180	Craniofacial Abnormalities	6.7%
181	Gout	6.6%
182	Fragile X Syndrome	6.6%
183	Nasopharyngeal Neoplasms	6.5%
184	Meconium Aspiration Syndrome	6.5%
185	Bronchomalacia	6.5%
186	Tracheomalacia	6.5%
187	Blepharophimosis	6.4%
188	Laryngostenosis	6.4%
189	Pseudoxanthoma Elasticum	6.4%
190	Pharyngitis	6.4%
191	Esophageal Atresia	6.4%
192	Intestinal Atresia	6.4%
193	Horseshoe Kidney	6.4%
194	Vesicular Stomatitis	6.4%
195	Acrodermatitis	6.3%
196	Lymphangiectasis, Intestinal	6.3%
197	Gianotti-Crosti Syndrome	6.3%
198	Contracture	6.3%
199	Osteoarthropathy, Secondary Hypertrophic	6.3%
200	Fasciitis, Plantar	6.3%
201	Bone Diseases	6.2%
202	Fasciitis	6.2%
203	Foot Deformities	6.2%
204	Arthropathy	6.2%
205	Sicca Syndrome	6.1%
206	Sjogren's Syndrome	6.1%
207	Multiple Epiphyseal Dysplasia	6%
208	Osteochondrodysplasias	6%
209	Xeroderma Pigmentosum	6%
210	Sjogren-Larsson Syndrome	6%
211	Choanal Atresia	6%
212	Tracheobronchomegaly	6%
213	Laryngocele	6%
214	Choledochal Cyst	5.9%
215	Hermaphroditism	5.9%
216	Disorders of Sex Development	5.9%
217	Cryptorchidism	5.9%
218	Hypospadias	5.9%
219	Central Nervous System Cysts	5.9%
220	Pharyngeal Neoplasms	5.9%
221	Dandy-Walker Syndrome	5.9%
222	POEMS Syndrome	5.8%
223	Herpes Zoster Oticus	5.8%
224	Fibromyalgia	5.8%
225	Osteochondritis	5.8%
226	Polymyalgia Rheumatica	5.8%
227	Leukoplakia, Oral	5.8%
228	Metatarsalgia	5.8%
229	Herpes Labialis	5.8%
230	Primary Ciliary Dyskinesia	5.7%
231	Dwarfism	5.6%
232	Cartilage Diseases	5.6%
233	Foot Diseases	5.6%
234	Myopathy	5.6%
235	Rheumatism	5.6%
236	Chondromalacia	5.6%
237	Zellweger Syndrome	5.6%
238	Muscular Dystrophy	5.5%
239	Gingivitis	5.5%
240	Glossitis, Benign Migratory	5.5%
241	Pericoronitis	5.5%
242	Aggressive Periodontitis	5.5%
243	Gingival Overgrowth	5.5%
244	Bladder Exstrophy	5.5%
245	Epispadias	5.5%
246	Multicystic Dysplastic Kidney	5.4%
247	Myotonic Dystrophy	5.4%
248	Facial Nerve Injuries	5.4%
249	Congenital clubfoot	5.3%
250	Vertical Talus	5.3%
251	Kallmann Syndrome	5.1%
252	Classical Lissencephalies and Subcortical Band Heterotopias	5.1%
253	Trigeminal Nerve Disorder	5%
254	Lemierre Syndrome	5%
255	Muscular Dystrophy, Duchenne	5%
256	Osteogenesis Imperfecta	5%
257	Toxic Epidermal Necrolysis	5%
258	Stevens-Johnson Syndrome	5%
259	Ischemic contracture	4.9%
260	Dental caries	4.9%
261	Dental Plaque	4.9%
262	Dental Pulp Calcification	4.9%
263	Pulpitis	4.9%
264	Tooth Erosion	4.9%
265	Osteoarthritis, Spine	4.7%
266	Polycystic Kidney, Autosomal Dominant	4.7%
267	Tuberous Sclerosis	4.7%
268	Rheumatic Fever	4.6%
269	Refsum Disease	4.6%
270	Klinefelter Syndrome	4.6%
271	Gingival Hyperplasia	4.5%
272	Gingival Hypertrophy	4.5%
273	Abdominal Cramps	4.5%
274	Amniotic Band Syndrome	4.5%
275	Asphyxia Neonatorum	4.5%
276	Infant, Premature, Diseases	4.5%
277	Infantile Colic	4.5%
278	Tooth Avulsion	4.5%
279	Dental Pulp Necrosis	4.5%
280	Nasopharyngeal carcinoma	4.4%
281	Charcot-Marie-Tooth Disease	4.4%
282	Congenital Hypothyroidism	4.4%
283	Arthritis, Gouty	4.3%
284	Rheumatoid Arthritis	4.3%
285	Juvenile arthritis	4.3%
286	Ectopia Cordis	4.2%
287	Meningomyelocele	4.2%
288	Spina Bifida	4.2%
289	Single umbilical artery	4.2%
290	Neoplastic Syndromes, Hereditary	4.2%
291	Albinism	4.2%
292	Hyperkeratosis, Epidermolytic	4.1%
293	Mumps	4.1%
294	Trigeminal Neuralgia	4.1%
295	Anemia, Neonatal	4.1%
296	Pelger-Huet Anomaly	4.1%
297	Persistent Fetal Circulation Syndrome	4.1%
298	Werner Syndrome	4.1%
299	Myasthenic Syndromes, Congenital	4.1%
300	Tonsillitis	4.1%
301	Sleep Bruxism	4.1%
302	Umbilical hernia	4.1%
303	Anemia, Sickle Cell	3.9%
304	Thalassemia	3.9%
305	Aortic coarctation	3.9%
306	Cor Triatriatum	3.9%
307	Coronary Vessel Anomalies	3.9%
308	Patent ductus arteriosus	3.9%
309	Ebstein Anomaly	3.9%
310	Heart Septal Defects	3.9%
311	Meningocele	3.9%
312	Tetralogy of Fallot	3.9%
313	Transposition of Great Vessels	3.9%
314	Hypoplastic Left Heart Syndrome	3.9%
315	May-Thurner Syndrome	3.9%
316	Encephalocele	3.9%
317	Hip Contracture	3.9%
318	Periarthritis	3.9%
319	Wolff-Parkinson-White Syndrome	3.9%
320	Familial Periodic Paralysis	3.8%
321	Neonatal Abstinence Syndrome	3.8%
322	Ulcerative stomatitis	3.8%
323	Retropharyngeal Abscess	3.8%
324	Fetal Growth Retardation	3.8%
325	Hypopharyngeal Neoplasms	3.8%
326	Hypopharyngeal Cancer	3.8%
327	Fetal Hypoxia	3.8%
328	Congenital nystagmus	3.8%
329	Fetal Alcohol Spectrum Disorders	3.8%
330	Toxoplasmosis, Congenital	3.7%
331	Syphilis, Congenital	3.7%
332	Hyperandrogenism	3.7%
333	Long QT Syndrome	3.6%
334	Myotonia Congenita	3.6%
335	Tricuspid Atresia	3.6%
336	Arrhythmogenic Right Ventricular Dysplasia	3.6%
337	Gonadal Dysgenesis	3.6%
338	Adrenogenital Syndrome	3.6%
339	Ovotesticular Disorders of Sex Development	3.6%
340	Gigantism	3.5%
341	Spinal Neoplasms	3.5%
342	Spondylitis	3.5%
343	Ankylosing spondylitis	3.5%
344	Autoimmune Lymphoproliferative Syndrome	3.5%
345	Congenital Hyperinsulinism	3.5%
346	Chorioamnionitis	3.5%
347	Angioedemas, Hereditary	3.5%
348	Arthritis	3.4%
349	Bone Diseases, Developmental	3.4%
350	Bursitis	3.4%
351	Hyperostosis	3.4%
352	Joint Instability	3.4%
353	Myofascial Pain Syndromes	3.4%
354	Osteitis	3.4%
355	Osteitis Deformans	3.4%
356	Osteochondrosis	3.4%
357	Rhabdomyolysis	3.4%
358	Spinal Diseases	3.4%
359	Synovitis	3.4%
360	Joint laxity	3.4%
361	Polyarthritis	3.4%
362	Frozen shoulder	3.4%
363	Patellofemoral Pain Syndrome	3.4%
364	Wiskott-Aldrich Syndrome	3.4%
365	Welander Distal Myopathy	3.3%
366	Osteoarthritis, Knee	3.3%
367	Arthritis, Psoriatic	3.2%
368	Menkes Kinky Hair Syndrome	3.2%
369	Bone Diseases, Endocrine	3.2%
370	Bone Diseases, Infectious	3.2%
371	Bone neoplasms	3.2%
372	Compartment syndromes	3.2%
373	Osteopenia	3.2%
374	Tendinitis	3.2%
375	Tendinopathy	3.2%
376	Bone Resorption	3.1%
377	Hemarthrosis	3.1%
378	Myositis	3.1%
379	Tietze's Syndrome	3.1%
380	Isaacs syndrome	3.1%
381	Aseptic Necrosis of Bone	3.1%
382	Myotonic Disorders	3.1%
383	Mucopolysaccharidosis II	3%
384	Ophthalmia Neonatorum	3%
385	Rheumatoid Nodule	3%
386	Medial Tibial Stress Syndrome	2.9%
387	Mitochondrial Myopathies	2.9%
388	Dermal Sinus	2.9%
389	Spina Bifida Cystica	2.9%
390	Spina Bifida Occulta	2.9%
391	Lissencephaly	2.9%
392	Polymicrogyria	2.9%
393	Pachygyria	2.9%
394	Schizencephaly	2.9%
395	Periventricular Nodular Heterotopia	2.9%
396	Adrenoleukodystrophy	2.9%
397	Muscle Cramp	2.9%
398	Eosinophilia-Myalgia Syndrome	2.9%
399	Muscle Rigidity	2.9%
400	Muscle Spasticity	2.9%
401	Cogwheel Rigidity	2.9%
402	Nuchal Rigidity	2.9%
403	Ataxia Telangiectasia	2.8%
404	Hepatolenticular Degeneration	2.8%
405	Felty Syndrome	2.8%
406	Peritonsillar Abscess	2.7%
407	Arthritis, Reactive	2.7%
408	Tonsillar Neoplasms	2.7%
409	Chronic Fatigue Syndrome	2.7%
410	Muscle Weakness	2.7%
411	Musculoskeletal Pain	2.7%
412	Arthralgia	2.6%
413	Polyarthralgia	2.6%
414	Aortopulmonary Septal Defect	2.6%
415	Double Outlet Right Ventricle	2.6%
416	Endocardial Cushion Defects	2.6%
417	Myocardial bridging	2.6%
418	Aorticopulmonary Septal Defect	2.6%
419	Pseudohypoparathyroidism	2.6%
420	Rett Syndrome	2.6%
421	Rheumatoid Vasculitis	2.6%
422	Neuronal Ceroid-Lipofuscinoses	2.6%
423	Amyloid Neuropathies, Familial	2.5%
424	Familial Mediterranean Fever	2.5%
425	Eosinophilic Granuloma	2.5%
426	Myalgia	2.5%
427	Discitis	2.4%
428	Hypokalemic periodic paralysis	2.4%
429	Romano-Ward Syndrome	2.4%
430	Sickle Cell Trait	2.4%
431	Spondylarthropathies	2.4%
432	Fabry Disease	2.3%
433	Paralysis, Obstetric	2.3%
434	Retinopathy of Prematurity	2.3%
435	Amino Acid Metabolism, Inborn Errors	2.3%
436	Carbohydrate Metabolism, Inborn Errors	2.3%
437	Metal Metabolism, Inborn Errors	2.3%
438	Progeria	2.3%
439	Lysosomal Storage Diseases	2.3%
440	Cytochrome-c Oxidase Deficiency	2.3%
441	Peroxisomal Disorders	2.3%
442	Bronchopulmonary Dysplasia	2.3%
443	Hydrops Fetalis	2.3%
444	Tuberculosis, Spinal	2.2%
445	Denys-Drash Syndrome	2.2%
446	Respiratory Distress Syndrome, Newborn	2.1%
447	Cutis Laxa	2.1%
448	Ainhum	2.1%
449	Bunion	2.1%
450	Dysostoses	2.1%
451	Fibrodysplasia Ossificans Progressiva	2.1%
452	Myoglobinuria	2.1%
453	Myositis Ossificans	2.1%
454	Spinal Stenosis	2.1%
455	Spondylosis	2.1%
456	Tenosynovitis	2.1%
457	Intervertebral Disc Degeneration	2.1%
458	Sacroiliitis	2.1%
459	Retinitis Pigmentosa	2.1%
460	Pigmentary retinopathy	2.1%
461	Arteriovenous fistula	2.1%
462	Porokeratosis	2.1%
463	Keratoderma, Palmoplantar	2.1%
464	Chronic granulomatous disease	2.1%
465	Canavan Disease	2.1%
466	Alexander Disease	2.1%
467	Acute Chest Syndrome	2.1%
468	Galactosemias	2.1%
469	Urea Cycle Disorders, Inborn	2.1%
470	Tyrosinemias	2.1%
471	Truncus Arteriosus, Persistent	2%
472	Duane Retraction Syndrome	2%
473	Porphyrias, Hepatic	2%
474	Peutz-Jeghers Syndrome	1.9%
475	Thrombasthenia	1.9%
476	Antithrombin III Deficiency	1.9%
477	Protein C Deficiency	1.9%
478	Brain Diseases, Metabolic, Inborn	1.9%
479	Afibrinogenemia	1.9%
480	Dystonia Musculorum Deformans	1.9%
481	Factor VII Deficiency	1.9%
482	Factor X Deficiency	1.9%
483	Factor XII Deficiency	1.9%
484	Hemophilia A	1.9%
485	Leukomalacia, Periventricular	1.9%
486	Activated Protein C Resistance	1.9%
487	Factor II deficiency	1.9%
488	Factor VIII Deficiency	1.9%
489	Factor V deficiency	1.9%
490	Factor XI Deficiency	1.9%
491	Hypoprothrombinemias	1.9%
492	Arthritis, Infectious	1.9%
493	Fanconi Anemia	1.9%
494	Nesidioblastosis	1.9%
495	Lafora Disease	1.9%
496	Unverricht-Lundborg Syndrome	1.9%
497	Anemia, Diamond-Blackfan	1.9%
498	Anterior Compartment Syndrome	1.9%
499	Osteomyelitis	1.9%
500	Osteoporosis	1.9%
501	Periostitis	1.9%
502	Enthesopathy	1.9%
503	Bone Demineralization, Pathologic	1.9%
504	Post-Traumatic Osteoporosis	1.9%
505	Arthritis, Experimental	1.9%
506	Abdominal Compartment Syndrome	1.9%
507	Optic Atrophy, Hereditary, Leber	1.9%
508	Femur Head Necrosis	1.9%
509	Polymyositis	1.9%
510	Osteolysis	1.9%
511	Hyperphosphaturia	1.9%
512	Glycogen storage disease type II	1.8%
513	Multiple Endocrine Neoplasia	1.8%
514	Dermatitis, Atopic	1.8%
515	Hip Dislocation	1.8%
516	Shoulder Dislocation	1.8%
517	Hip Dysplasia	1.8%
518	Orbital Myositis	1.8%
519	Dupuytren Contracture	1.8%
520	Pyomyositis	1.8%
521	Acromegaly	1.8%
522	Joint Tuberculosis	1.8%
523	Tuberculosis, Osteoarticular	1.8%
524	Bone Tuberculosis	1.8%
525	Kernicterus	1.7%
526	MELAS Syndrome	1.7%
527	Rickets	1.6%
528	Homocystinuria	1.6%
529	Shoulder Pain	1.6%
530	Leigh Disease	1.6%
531	Huntington Disease	1.6%
532	Familial Hypophosphatemic Rickets	1.5%
533	Mitochondrial Encephalomyopathies	1.5%
534	Mucopolysaccharidosis III	1.5%
535	Nephroblastoma	1.5%
536	Chondrodysplasia Punctata	1.5%
537	Enchondromatosis	1.5%
538	Lordosis	1.5%
539	Osteosclerosis	1.5%
540	Spondylolysis	1.5%
541	kyphosis	1.5%
542	Kashin-Beck Disease	1.5%
543	Alkaptonuria	1.4%
544	Glycogen Storage Disease	1.4%
545	Hypophosphatasia	1.4%
546	Propionic acidemia	1.4%
547	Dihydropyrimidine Dehydrogenase Deficiency	1.4%
548	Cystinosis	1.4%
549	Adenomatous Polyposis Coli	1.4%
550	Gaucher Disease	1.3%
551	Osteoporosis, Postmenopausal	1.3%
552	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.3%
553	Hyaline Membrane Disease	1.3%
554	Hypolipoproteinemias	1.3%
555	Papillon-Lefevre Disease	1.3%
556	Hyperlipidemia, Familial Combined	1.3%
557	Hyperlipoproteinemia Type III	1.3%
558	Mastoiditis	1.2%
559	Petrositis	1.2%
560	Lactose Intolerance	1.2%
561	Variegate Porphyria	1.2%
562	Acute intermittent porphyria	1.2%
563	Porphyria Cutanea Tarda	1.2%
564	Hyperhomocysteinemia	1.2%
565	Renal Aminoacidurias	1.2%
566	Fanconi Syndrome	1.2%
567	Pseudohypoaldosteronism	1.2%
568	Liddle Syndrome	1.2%
569	Hyperlipoproteinemia Type IV	1.2%
570	Hyperlipoproteinemia Type V	1.2%
571	Dermatomyositis	1.1%
572	Melorheostosis	1.1%
573	Osteopetrosis	1.1%
574	Spondylolisthesis	1.1%
575	Osteomalacia	1.1%
576	Multiple Endocrine Neoplasia Type 1	1.1%
577	Friedreich Ataxia	1.1%
578	Renal tubular acidosis	1.1%
579	Niemann-Pick Disease, Type C	1.1%
580	Tay-Sachs Disease	1%
581	Glycosuria, Renal	1%
582	Glycogen Storage Disease Type I	1%
583	Glycogen Storage Disease Type V	1%
584	Nose Neoplasms	0.9%
585	Renal Osteodystrophy	0.9%
586	Renal rickets	0.9%
587	Hypoalphalipoproteinemias	0.9%
588	Cystinuria	0.8%
589	Kearns-Sayre syndrome	0.8%

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