MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Meningitis, Pneumococcal

(UMLS:C0025295)

Definition:: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
UMLS ID:: C0025295
MeSH ID:: D008586

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.200.500.600|C01.252.410.890.670.595

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.228.180.500.875|C10.228.614.280.560

Synonym(s)

Meningitis, Pneumococcal

MENINGITIS PNEUMOCOCCAL

Meningitis pneumococcal

PNEUMOCOCCAL MENINGITIS

Pneumococcal Meningitis

Pneumococcal meningitis

meningitis pneumococcal

meningitis; pneumococcal

pneumococcal meningitis

10.

pneumococcal; meningitis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Cefotaxime	1495831 1601755	CTD
2	Ceftriaxone	9157169 11305469	CTD
3	Chloramphenicol	1923686	CTD
4	Cilastatin, Imipenem Drug Combination	8515296	CTD
5	Clarithromycin	11305469	CTD
6	Dexamethasone	17267155	CTD
7	Fosfomycin	1495831 8309909	CTD
8	Rifampin	7870156 8309909 9157169	CTD
9	Vancomycin	7870156 8309909 9157169	CTD
10	cefpirome	1601755	CTD
11	telavancin	16436742	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Meningitis, Listeria	48.5%
2	Tuberculosis, Meningeal	46.7%
3	Meningitis, Haemophilus	44.8%
4	Meningoencephalitis	33.2%
5	Encephalomyelitis	30.1%
6	Neurosyphilis	28.9%
7	Lyme Neuroborreliosis	28.3%
8	Epidural Abscess	25.5%
9	Meningitis, Fungal	23.4%
10	Myelitis	23.2%
11	Brain Abscess	23%
12	Waterhouse-Friderichsen Syndrome	20.8%
13	Tuberculosis, Central Nervous System	20%
14	Prion Diseases	19.7%
15	Central Nervous System Fungal Infections	19.7%
16	Erysipelas	19.6%
17	Impetigo	18.8%
18	Brain Diseases	18.6%
19	Movement Disorders	18.6%
20	Spinal Cord Diseases	18.6%
21	Gram-Negative Bacterial Infections	18.6%
22	Ocular Motility Disorders	18.5%
23	Cyclophoria	18.5%
24	Arachnoiditis	18.4%
25	Aseptic Meningitis	18.4%
26	Central Nervous System Infection	18.4%
27	Scarlet Fever	18.3%
28	Borrelia Infections	17.8%
29	Leptospirosis	17.8%
30	Subdural Effusion	17.7%
31	Ecthyma	17.4%
32	Subacute Bacterial Endocarditis	17.4%
33	Pneumocephalus	17.3%
34	Multiple System Atrophy	17.2%
35	Actinomycetales Infections	17.1%
36	Clostridium Infections	17.1%
37	Listeriosis	17.1%
38	Staphylococcal Infections	17.1%
39	Bacillaceae Infections	17.1%
40	Clostridium difficile infection	17.1%
41	Skin Diseases, Bacterial	16%
42	Bacteremia	15.9%
43	Meningitis, Cryptococcal	15.7%
44	Bacterial Vaginosis	15.4%
45	Central Nervous System Bacterial Infections	15.2%
46	Poliomyelitis	14.8%
47	Erysipelothrix infection	14.8%
48	Stiff-Person Syndrome	14.7%
49	Staphylococcal Skin Infections	14.7%
50	Parkinsonian Disorders	14.5%
51	Lyme Disease	14.4%
52	Relapsing Fever	14.4%
53	Cerebral Ventriculitis	14.4%
54	Lupus Vasculitis, Central Nervous System	14.4%
55	Bacterial Endocarditis	14.1%
56	Lewy Body Disease	13.7%
57	Toxoplasmosis, Cerebral	13.6%
58	Pneumonia, Bacterial	13.4%
59	Rheumatic Fever	13.3%
60	Syphilis	13.2%
61	Subacute Combined Degeneration	13%
62	Botulism	12.9%
63	Spinal Muscular Atrophy	12.8%
64	Progressive Muscular Atrophy	12.8%
65	Parkinson Disease	12.8%
66	Neuroaspergillosis	12.7%
67	Erythrasma	12.7%
68	Spinal Cord Injuries	12.6%
69	Dandy-Walker Syndrome	12.4%
70	Erythema Chronicum Migrans	12.4%
71	Creutzfeldt-Jakob disease	12.4%
72	Leukoencephalopathy, Progressive Multifocal	12.4%
73	Asterixis	12.2%
74	Ballismus	12.2%
75	Amyotrophic Lateral Sclerosis	12%
76	Mycetoma	11.9%
77	Myelitis, Transverse	11.8%
78	Cranial nerve diseases	11.7%
79	Demyelinating Diseases	11.7%
80	Demyelination	11.7%
81	Mycoses	11.7%
82	Neuromuscular Diseases	11.7%
83	Chronobiology Disorders	11.7%
84	Infection	11.7%
85	Limbic Encephalitis	11.7%
86	Progressive supranuclear palsy	11.6%
87	Meige Syndrome	11.2%
88	Human Ehrlichiosis	11.2%
89	Chronic Fatigue Syndrome	11.1%
90	Dementia, Vascular	10.9%
91	Chlamydia Infections	10.9%
92	Gonorrhea	10.9%
93	Marchiafava-Bignami Disease	10.9%
94	Striatonigral Degeneration	10.9%
95	Dystonia Musculorum Deformans	10.7%
96	Akinetic Mutism	10.6%
97	Anoxic Encephalopathy	10.6%
98	Basal Ganglia Diseases	10.6%
99	Bordetella Infections	10.6%
100	Brain Damage, Chronic	10.6%
101	Brucellosis	10.6%
102	Campylobacter infection	10.6%
103	Cerebellar Diseases	10.6%
104	Encephalitis	10.6%
105	Encephalomalacia	10.6%
106	Enterobacteriaceae Infections	10.6%
107	Epilepsy	10.6%
108	Hydrocephalus	10.6%
109	Congenital Hydrocephalus	10.6%
110	Hypothalamic Diseases	10.6%
111	Pseudomonas Infections	10.6%
112	Q Fever	10.6%
113	Syringomyelia	10.6%
114	Thalamic Diseases	10.6%
115	Vibrio Infections	10.6%
116	Helicobacter Infections	10.6%
117	Neisseriaceae Infections	10.6%
118	Intracranial Hypertension	10.6%
119	Aura	10.6%
120	Leukoencephalopathy	10.6%
121	Essential Tremor	10.6%
122	Burkholderia Infections	10.6%
123	Neuroaxonal Dystrophies	10.6%
124	Familial Tremor	10.6%
125	Headache Disorders	10.6%
126	Intracranial Hypotension	10.6%
127	Flavobacteriaceae Infections	10.6%
128	Moraxellaceae Infections	10.6%
129	Brain Edema	10.6%
130	Brain Hypoxia	10.6%
131	Burkholderia cepacia Infection	10.6%
132	Aqueductal Stenosis	10.6%
133	Pneumorrhachis	10.6%
134	Writer's Cramp	10.6%
135	Actinomycosis	10.6%
136	Corynebacterium Infections	10.6%
137	Gas Gangrene	10.6%
138	Mycobacterium Infections	10.6%
139	Nocardia Infections	10.6%
140	Tetanus	10.6%
141	Pulmonary Nocardiosis	10.6%
142	Rheumatic Heart Disease	10.6%
143	Motor Neuron Disease	10.5%
144	Scrapie	10.3%
145	Brain Injuries	10.2%
146	Brain Neoplasms	10.2%
147	Spinal Cord Neoplasms	10.2%
148	Trauma, Nervous System	10.1%
149	Huntington Disease	10%
150	Human anaplasmosis	10%
151	Nervous System Neoplasms	9.9%
152	Neurologic Manifestations	9.9%
153	Neurotoxicity Syndromes	9.9%
154	Epilepsy, Post-Traumatic	9.8%
155	Gram-Positive Bacterial Infections	9.8%
156	Staphylococcal Scalded Skin Syndrome	9.8%
157	Restless Legs Syndrome	9.8%
158	Meningitis, Bacterial	9.7%
159	Shy-Drager Syndrome	9.7%
160	Basal Ganglia Cerebrovascular Disease	9.7%
161	Posterior Leukoencephalopathy Syndrome	9.6%
162	Japanese Spotted Fever	9.6%
163	Posterior reversible encephalopathy syndrome	9.6%
164	Akathisia, Drug-Induced	9.5%
165	Ophthalmoplegic Migraine	9.5%
166	Neuroleptic Malignant Syndrome	9.3%
167	Myelinolysis, Central Pontine	9.3%
168	MPTP Poisoning	9.3%
169	Polyradiculoneuropathy	9.3%
170	Polyradiculoneuritis	9.3%
171	Opsoclonus-Myoclonus Syndrome	9.3%
172	Hidradenitis Suppurativa	9.2%
173	Brain Diseases, Metabolic	9%
174	Cerebrovascular Disorders	9%
175	Cerebrovascular Insufficiency	9%
176	Dementia	9%
177	Conus Medullaris Syndrome	9%
178	Spinal Cord Vascular Diseases	9%
179	Meningitis	8.8%
180	Pachymeningitis	8.8%
181	Furunculosis	8.8%
182	furuncle	8.8%
183	Hepatolenticular Degeneration	8.7%
184	Sleep Wake Disorders	8.6%
185	Subacute Sclerosing Panencephalitis	8.6%
186	Brain Death	8.5%
187	Leukomalacia, Periventricular	8.5%
188	Leukoencephalitis, Acute Hemorrhagic	8.5%
189	Dyskinesia, Drug-Induced	8.4%
190	Vascular Headaches	8.3%
191	Rhinoscleroma	8.3%
192	Hypoxia-Ischemia, Brain	8.2%
193	Hordeolum	8.2%
194	Autonomic Dysreflexia	8.2%
195	Complex Regional Pain Syndromes	8.2%
196	Cerebellar Neoplasms	8.2%
197	Amblyopia	8.1%
198	Bacterial conjunctivitis	8.1%
199	Myoclonic Epilepsy	8%
200	Epilepsy, Temporal Lobe	8%
201	Epilepsy, Rolandic	8%
202	Benign Rolandic Epilepsy	8%
203	Ulcerative stomatitis	7.9%
204	Miller Fisher Syndrome	7.7%
205	Friedreich Ataxia	7.7%
206	Enterocolitis, Pseudomembranous	7.6%
207	pseudomembranous colitis	7.6%
208	Pertussis	7.5%
209	Central Cord Syndrome	7.5%
210	Encephalomyelitis, Acute Disseminated	7.5%
211	Presenile dementia	7.4%
212	Senile dementia	7.4%
213	Chorea	7.4%
214	carbuncle	7.3%
215	Diphtheria	7.3%
216	Leprosy	7.3%
217	Mycobacterium Infections, Nontuberculous	7.3%
218	Tuberculosis	7.3%
219	Mycobacterium abscessus Infection	7.3%
220	Vasculitis, Central Nervous System	7.3%
221	Lymphogranuloma Venereum	7.3%
222	Meningitis, Pneumococcal	7.2%
223	Rocky Mountain Spotted Fever	7.2%
224	Peripheral Nerve Injuries	7.1%
225	Dermatomycoses	7%
226	Myasthenia Gravis	7%
227	Syphilis, Congenital	6.9%
228	Pseudorabies	6.9%
229	Guillain-Barre Syndrome	6.8%
230	Brain Hemorrhage, Traumatic	6.8%
231	Amnesia, Transient Global	6.8%
232	Lambert-Eaton Myasthenic Syndrome	6.7%
233	Acinetobacter Infections	6.7%
234	Bacteroides Infections	6.7%
235	Cerebral Palsy	6.7%
236	Cholera	6.7%
237	Epilepsies, Partial	6.7%
238	Epilepsy, Generalized	6.7%
239	Escherichia coli Infections	6.7%
240	Haemophilus Infections	6.7%
241	Klebsiella Infections	6.7%
242	Meningococcal Infections	6.7%
243	Mycoplasma Infections	6.7%
244	Pasteurella Infections	6.7%
245	Proteus Infections	6.7%
246	Pseudotumor Cerebri	6.7%
247	Rickettsia Infections	6.7%
248	Salmonella infections	6.7%
249	Scrub Typhus	6.7%
250	Serratia Infections	6.7%
251	Ureaplasma Infections	6.7%
252	Hypertensive Encephalopathy	6.7%
253	Simple Partial Seizures	6.7%
254	Epilepsy, Reflex	6.7%
255	Headache Disorders, Primary	6.7%
256	Headache Disorders, Secondary	6.7%
257	Medication overuse headache	6.7%
258	Basal Ganglia Hemorrhage	6.7%
259	Joint Tuberculosis	6.7%
260	Tuberculosis, Osteoarticular	6.7%
261	Bone Tuberculosis	6.7%
262	Ophthalmia Neonatorum	6.6%
263	Trachoma	6.6%
264	Carotid Artery Injuries	6.6%
265	Canavan Disease	6.6%
266	Alexander Disease	6.6%
267	Paraneoplastic Cerebellar Degeneration	6.5%
268	Lafora Disease	6.4%
269	Unverricht-Lundborg Syndrome	6.4%
270	Brain Injuries, Diffuse	6.4%
271	Traumatic Brain Injury	6.4%
272	Cerebellar Ataxia	6.4%
273	Supratentorial Neoplasms	6.4%
274	Torticollis	6.4%
275	Juvenile Myoclonic Epilepsy	6.4%
276	Myoclonic Epilepsies, Progressive	6.4%
277	Sleep Disorders, Circadian Rhythm	6.3%
278	West Nile Fever	6.2%
279	Pituitary Adenoma	6.2%
280	Pituitary Neoplasms	6.2%
281	Aspergillosis	6.2%
282	Candidiasis	6.2%
283	Coccidioidomycosis	6.2%
284	Dysautonomia	6.2%
285	Histoplasmosis	6.2%
286	Paracoccidioidomycosis	6.2%
287	Pelvic Infection	6.2%
288	Wound Infection	6.2%
289	Zygomycosis	6.2%
290	Soft Tissue Infection	6.2%
291	Vagus Nerve Disorder	6.2%
292	Glossopharyngeal Neuralgia	6.2%
293	Community-Acquired Infections	6.2%
294	Abducens Nerve Diseases	6.2%
295	Phaeohyphomycosis	6.2%
296	Heavy Metal Poisoning, Nervous System	6.2%
297	Neuromuscular Junction Diseases	6.2%
298	Pneumocystis Infections	6.2%
299	Tauopathies	6.2%
300	Trochlear Nerve Diseases	6.2%
301	Peripheral Nervous System Diseases	6.2%
302	Central Nervous System Cysts	6.1%
303	Erythema Induratum	6.1%
304	Pituitary Apoplexy	6.1%
305	Brain Infarction	6%
306	Progressive bulbar palsy	5.9%
307	Bulbar palsy	5.9%
308	Persistent Vegetative State	5.9%
309	Candidiasis, Chronic Mucocutaneous	5.9%
310	Cutaneous Candidiasis	5.9%
311	Olfactory Nerve Injuries	5.9%
312	Pituitary Diseases	5.8%
313	Streptococcal Infections	5.8%
314	Neuromyelitis Optica	5.8%
315	Causalgia	5.8%
316	Mycobacterium avium-intracellulare Infection	5.7%
317	Lymph Node Tuberculosis	5.7%
318	Tuberculosis, Miliary	5.7%
319	Tuberculosis, Multidrug-Resistant	5.7%
320	Leprosy, Multibacillary	5.7%
321	Latent Tuberculosis	5.7%
322	Carotid Artery Diseases	5.6%
323	Brain Ischemia	5.6%
324	Cerebrovascular accident	5.6%
325	Kluver-Bucy Syndrome	5.6%
326	Vasospasm, Intracranial	5.6%
327	Spinal Cord Ischemia	5.6%
328	Intracranial Arterial Diseases	5.6%
329	Panophthalmitis	5.5%
330	Putaminal Hemorrhage	5.5%
331	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.5%
332	Eye Infection	5.4%
333	Myopathy	5.4%
334	Respiratory Tract Infections	5.4%
335	Optic Neuropathy	5.4%
336	Toxoplasmosis, Congenital	5.3%
337	Malaria, Cerebral	5.3%
338	Horner Syndrome	5.3%
339	Neurocysticercosis	5.3%
340	Ataxia Telangiectasia	5.3%
341	Bone Diseases, Infectious	5.2%
342	Facial Nerve Diseases	5.2%
343	Craniocerebral Trauma	5.2%
344	Otomycosis	5.2%
345	Parasomnia	5.2%
346	Pregnancy Complications, Infectious	5.2%
347	Skin Diseases, Infectious	5.2%
348	Dyssomnias	5.2%
349	Facial Nerve Injuries	5.2%
350	Infarction, Middle Cerebral Artery	5.2%
351	Infarction, Anterior Cerebral Artery	5.2%
352	Infarction, Posterior Cerebral Artery	5.2%
353	Vestibulocochlear Nerve Diseases	5.2%
354	Arthritis, Infectious	5.2%
355	Decerebrate State	5.2%
356	Hemiparesis	5.2%
357	Hydranencephaly	5.2%
358	Meningism	5.2%
359	Neural Tube Defects	5.2%
360	Paresis	5.2%
361	Piedra	5.2%
362	Seizures	5.2%
363	Sensation Disorders	5.2%
364	Tethered Cord Syndrome	5.2%
365	Central Nervous System Neoplasms	5.2%
366	Complex partial seizures	5.2%
367	Iniencephaly	5.2%
368	Craniorachischisis	5.2%
369	Exencephaly	5.2%
370	Monoparesis	5.2%
371	Septo-Optic Dysplasia	5.2%
372	Cortical Dysplasia	5.2%
373	Neurogenic Inflammation	5.2%
374	Gait Disorders, Neurologic	5.2%
375	Neuromuscular Manifestations	5.2%
376	Malformations of Cortical Development	5.2%
377	Suppuration	5.2%
378	Cross Infection	5.2%
379	Septicemia	5.2%
380	Sweating, Gustatory	5.2%
381	Auriculotemporal Syndrome	5.2%
382	Sepsis	5.2%
383	Multiple Sclerosis	5.1%
384	Fungemia	5.1%
385	Mitochondrial Encephalomyopathies	5%
386	Tardive Dyskinesia	5%
387	Candidemia	5%
388	Borderline leprosy	4.9%
389	Leprosy, Lepromatous	4.9%
390	Tuberculoid leprosy	4.9%
391	Extensively Drug-Resistant Tuberculosis	4.9%
392	Tuberculosis, Gastrointestinal	4.9%
393	Reye Syndrome	4.9%
394	Intracranial Embolism and Thrombosis	4.8%
395	Hepatic Encephalopathy	4.8%
396	Reflex Sympathetic Dystrophy	4.8%
397	Nocturnal Myoclonus Syndrome	4.8%
398	Dysentery, Bacillary	4.8%
399	Moyamoya Disease	4.8%
400	Psittacosis	4.8%
401	Paratyphoid Fever	4.8%
402	Plague	4.8%
403	Post-Traumatic Headache	4.8%
404	Tension Headache	4.8%
405	Typhoid Fever	4.8%
406	TYPHUS	4.8%
407	Yersinia pseudotuberculosis Infections	4.8%
408	Epilepsy, Complex Partial	4.8%
409	Migraine Disorders	4.8%
410	Abdominal Migraine	4.8%
411	Bubonic Plague	4.8%
412	Status Migrainosus	4.8%
413	Cervicogenic Headache	4.8%
414	Cerebral Infarction	4.8%
415	Brain Stem Infarctions	4.8%
416	Tuberous Sclerosis	4.7%
417	Jet Lag Syndrome	4.7%
418	Opportunistic Infections	4.7%
419	Blastomycosis	4.7%
420	Myasthenia Gravis, Autoimmune, Experimental	4.7%
421	Vertebral Artery Dissection	4.7%
422	Adrenoleukodystrophy	4.7%
423	Pupil Disorders	4.6%
424	Neurobehavioral Manifestations	4.6%
425	Diffuse Axonal Injury	4.6%
426	Brain Stem Neoplasms	4.6%
427	Lung Diseases, Fungal	4.5%
428	Auditory Perceptual Disorders	4.5%
429	Cellulitis	4.5%
430	Ophthalmoplegia	4.5%
431	External Ophthalmoplegia	4.5%
432	Urinary tract infection	4.5%
433	Paraneoplastic Encephalomyelitis	4.5%
434	Tuberculosis, Spinal	4.5%
435	Subarachnoid Hemorrhage, Traumatic	4.5%
436	Carotid Artery, Internal, Dissection	4.5%
437	Uveomeningoencephalitic Syndrome	4.5%
438	Sturge-Weber Syndrome	4.4%
439	Vertigo	4.4%
440	Alcohol-Induced Disorders, Nervous System	4.4%
441	Frontotemporal dementia	4.4%
442	Brain Concussion	4.3%
443	MELAS Syndrome	4.3%
444	Brain Diseases, Metabolic, Inborn	4.3%
445	Tuberculosis, Pulmonary	4.2%
446	Alice in Wonderland Syndrome	4.2%
447	Pyomyositis	4.2%
448	Lateral Medullary Syndrome	4.2%
449	Salmonella Infections, Animal	4.2%
450	Chromoblastomycosis	4.1%
451	Dermatophytosis	4.1%
452	Sporotrichosis	4.1%
453	Tinea	4.1%
454	Tinea Versicolor	4.1%
455	Trichophytosis	4.1%
456	Invasive Pulmonary Aspergillosis	4.1%
457	Hyalohyphomycosis	4.1%
458	Acrodynia	4.1%
459	Endotoxemia	4.1%
460	Charcot-Marie-Tooth Disease	4.1%
461	Refsum Disease	4.1%
462	Empty Sella Syndrome	4.1%
463	Hyperpituitarism	4.1%
464	Hypopituitarism	4.1%
465	Hypophysitis	4.1%
466	Vocal Cord Paralysis	4%
467	Sexually Transmitted Diseases	4%
468	Salmonella food poisoning	4%
469	Brain Contusion	4%
470	Cerebral Arterial Diseases	4%
471	Vertebrobasilar Insufficiency	4%
472	Anterior Spinal Artery Syndrome	4%
473	Basilar Artery Stenosis	4%
474	Vertebral Artery Stenosis	4%
475	Intracranial Hemorrhage, Hypertensive	4%
476	Transient Cerebral Ischemia	4%
477	Voice Disorders	4%
478	Voice Disturbance	4%
479	Smith-Magenis syndrome	3.9%
480	Dural Arteriovenous Fistula	3.9%
481	Pneumococcal Infections	3.8%
482	Cluster Headache	3.8%
483	Migraine with Aura	3.8%
484	Familial Hemiplegic Migraine	3.8%
485	Chronic Paroxysmal Hemicrania	3.8%
486	SUNCT Syndrome	3.8%
487	Paroxysmal Hemicrania	3.8%
488	Giant Cell Arteritis	3.8%
489	Temporal Arteritis	3.8%
490	Wernicke Encephalopathy	3.8%
491	AIDS Dementia Complex	3.8%
492	Brachial Plexus Neuritis	3.7%
493	Neuralgic Amyotrophy	3.7%
494	Myotonia Congenita	3.7%
495	Choroid Plexus Papilloma	3.6%
496	Cerebrospinal Fluid Otorrhea	3.6%
497	Cerebrospinal Fluid Rhinorrhea	3.6%
498	Neuritis, Autoimmune, Experimental	3.6%
499	Gait Ataxia	3.6%
500	Alcohol Withdrawal Seizures	3.6%
501	Mucormycosis	3.5%
502	Neuritis	3.5%
503	Polyneuritis	3.5%
504	Radiculitis	3.5%
505	Polyneuropathy	3.5%
506	Mononeuritis	3.5%
507	Mononeuropathies	3.5%
508	Brachial Plexus Neuropathies	3.5%
509	Radiculopathy	3.5%
510	Mononeuropathy Multiplex	3.5%
511	Nerve Root Compression	3.5%
512	Coma, Post-Head Injury	3.5%
513	Kernicterus	3.5%
514	Carotid Stenosis	3.4%
515	Intracranial Aneurysm	3.4%
516	Reflex, Abnormal	3.4%
517	Hyporeflexia	3.4%
518	Hyperreflexia	3.4%
519	Intracranial Arteriosclerosis	3.4%
520	Cerebral Atherosclerosis	3.4%
521	Subarachnoid Hemorrhage	3.4%
522	Cerebral Arteriosclerosis	3.4%
523	Cerebral Hemorrhage	3.4%
524	Cerebral Thrombosis	3.4%
525	Intracranial Embolism	3.4%
526	Intracranial Thrombosis	3.4%
527	Myotonic Dystrophy	3.4%
528	Akathisia	3.2%
529	Restlessness	3.2%
530	Psychomotor Agitation	3.2%
531	Hyperprolactinemia	3.2%
532	Multiple Sclerosis, Chronic Progressive	3.2%
533	Multiple Sclerosis, Relapsing-Remitting	3.2%
534	Tarsal Tunnel Syndrome	3.2%
535	Cauda Equina Syndrome	3.2%
536	Subclavian Steal Syndrome	3.2%
537	Pick Disease of the Brain	3.2%
538	Hematoma, Subdural	3%
539	Hematoma, Epidural, Cranial	3%
540	Oral candidiasis	3%
541	Endophthalmitis	3%
542	Myositis	3%
543	Optic Atrophy	3%
544	Optic Neuritis	3%
545	Papilledema	3%
546	Peritonitis	3%
547	Strabismus	3%
548	Tolosa-Hunt Syndrome	3%
549	Isaacs syndrome	3%
550	Arsenic Poisoning	3%
551	Myotonic Disorders	3%
552	Myasthenic Syndromes, Congenital	3%
553	Carotid Artery Thrombosis	3%
554	Diabetic Neuropathies	3%
555	Facial Injuries	3%
556	Facial Neuralgia	3%
557	Osteomyelitis	3%
558	Periostitis	3%
559	Surgical Wound Infection	3%
560	Diabetic Amyotrophy	3%
561	Diabetic Autonomic Neuropathy	3%
562	Sleep Talking	3%
563	Manganese Poisoning	3%
564	Sleep Disorders, Intrinsic	3%
565	Orthostatic intolerance	3%
566	Pulmonary Aspergillosis	3%
567	Bronchopulmonary Aspergillosis	3%
568	Optic Nerve Glioma	3%
569	Abscess	3%
570	Adnexitis	3%
571	Anosmia	3%
572	Ataxia	3%
573	Athetosis	3%
574	Catalepsy	3%
575	Dystonia	3%
576	Empyema	3%
577	Hemiplegia	3%
578	Locked-In Syndrome	3%
579	Meningeal Neoplasms	3%
580	Meningomyelocele	3%
581	Muscle Hypertonia	3%
582	Muscle hypotonia	3%
583	Myoclonus	3%
584	Myotonia	3%
585	Neuralgia	3%
586	Paraplegia	3%
587	Pseudobulbar Palsy	3%
588	Quadriplegia	3%
589	Spasm	3%
590	Spastic Paraplegia	3%
591	Status Epilepticus	3%
592	Taste Disorders	3%
593	Tremor	3%
594	Spina Bifida	3%
595	Monoplegia	3%
596	Hypokinesia	3%
597	Paraparesis	3%
598	Bradykinesia	3%
599	Waxy flexibility	3%
600	Action Tremor	3%
601	Resting Tremor	3%
602	Dysosmia	3%
603	Pelvic Inflammatory Disease	3%
604	Quadriparesis	3%
605	Mercury Poisoning, Nervous System	3%
606	Olfaction Disorders	3%
607	Myokymia	3%
608	Lead Poisoning, Nervous System	3%
609	Vestibular Neuronitis	3%
610	Somatosensory Disorders	3%
611	Neuropathic pain	3%
612	Hyperkinesia	3%
613	Intention tremor	3%
614	Alstrom Syndrome	2.9%
615	Gait Apraxia	2.9%
616	Tuberculosis, Renal	2.8%
617	Acromegaly	2.8%
618	Carpal Tunnel Syndrome	2.8%
619	neurofibroma	2.7%
620	Sciatica	2.7%
621	Fusariosis	2.7%
622	Acoustic Neuroma	2.7%
623	Cerebral Amyloid Angiopathy	2.7%
624	Sinus Thrombosis, Intracranial	2.7%
625	Hand-Arm Vibration Syndrome	2.7%
626	Amyloid Neuropathies, Familial	2.6%
627	Vision Disorders	2.6%
628	Metamorphopsia	2.6%
629	Visual Impairment	2.6%
630	Fibromyalgia	2.6%
631	Superinfection	2.6%
632	Optic Neuropathy, Ischemic	2.6%
633	Anterior Ischemic Optic Neuropathy	2.6%
634	Medial Tibial Stress Syndrome	2.6%
635	Corneal Ulcer	2.6%
636	Facial Hemiatrophy	2.6%
637	Melkersson-Rosenthal Syndrome	2.6%
638	Mitochondrial Myopathies	2.6%
639	Anisocoria	2.6%
640	Confusion	2.6%
641	Facial paralysis	2.6%
642	Lethargy	2.6%
643	Memory Disorders	2.6%
644	Muscle Cramp	2.6%
645	Perceptual Disorders	2.6%
646	Psychomotor Disorders	2.6%
647	Tonic Pupil	2.6%
648	Eosinophilia-Myalgia Syndrome	2.6%
649	Anhedonia	2.6%
650	Disorientation	2.6%
651	Facial Paresis	2.6%
652	Memory Loss	2.6%
653	Hemisensory Neglect	2.6%
654	Dysacusis	2.6%
655	Puerperal Infection	2.6%
656	Spondylitis	2.6%
657	Sleep Bruxism	2.6%
658	Anencephaly	2.5%
659	Appendicitis	2.5%
660	Bacteriuria	2.5%
661	Meningocele	2.5%
662	Muscular Atrophy	2.5%
663	Pyuria	2.5%
664	Respiratory Paralysis	2.5%
665	Encephalocele	2.5%
666	Tetany	2.5%
667	Fabry Disease	2.5%
668	Endotoxic shock	2.5%
669	Septic Shock	2.5%
670	Toxic Shock Syndrome	2.5%
671	Candidiasis, Vulvovaginal	2.5%
672	Hematoma, Subdural, Intracranial	2.5%
673	Hematoma, Subdural, Chronic	2.5%
674	Hematoma, Subdural, Acute	2.5%
675	Lemierre Syndrome	2.4%
676	Tinea Capitis	2.4%
677	Onychomycosis	2.4%
678	Galactosemias	2.4%
679	Urea Cycle Disorders, Inborn	2.4%
680	Tyrosinemias	2.4%
681	Cavernous Sinus Thrombosis	2.4%
682	Sagittal Sinus Thrombosis	2.4%
683	Menkes Kinky Hair Syndrome	2.3%
684	Cubital Tunnel Syndrome	2.3%
685	Duane Retraction Syndrome	2.3%
686	Consciousness Disorders	2.3%
687	Mental Retardation	2.3%
688	Muscle Weakness	2.3%
689	Depressed Level of Consciousness	2.3%
690	Mental deficiency	2.3%
691	Intellectual Disability	2.3%
692	Mobius Syndrome	2.3%
693	Bell Palsy	2.3%
694	Catatonia	2.3%
695	Herpes Zoster Oticus	2.2%
696	Familial Periodic Paralysis	2.2%
697	Psoas Abscess	2.2%
698	Sciatic Neuropathy	2.2%
699	Ulnar Neuropathies	2.2%
700	Lesion of Sciatic Nerve	2.2%
701	Abdominal Abscess	2.2%
702	Ulnar Neuritis	2.2%
703	Radial nerve compression	2.2%
704	Radial Tunnel Syndrome	2.2%
705	Peroneal Neuropathies	2.2%
706	Radial Neuropathy	2.2%
707	Median Neuropathy	2.2%
708	Sciatic Nerve Palsy	2.2%
709	Femoral Neuropathy	2.2%
710	Tibial Neuropathy	2.2%
711	Ulnar Nerve Palsy	2.2%
712	Postural Orthostatic Tachycardia Syndrome	2.2%
713	Radial nerve palsy	2.2%
714	Aphonia	2.2%
715	Sleep Deprivation	2.2%
716	Dysphonia	2.2%
717	Arthritis, Reactive	2.2%
718	Homocystinuria	2.2%
719	Leigh Disease	2.2%
720	Prolactinoma	2.2%
721	Growth Hormone-Secreting Pituitary Adenoma	2.2%
722	Tinea Pedis	2.1%
723	Classical Lissencephalies and Subcortical Band Heterotopias	2.1%
724	Nelson Syndrome	2.1%
725	AIDS-Related Opportunistic Infections	2%
726	Myalgia	2%
727	Neuronal Ceroid-Lipofuscinoses	2%
728	Thoracic Outlet Syndrome	1.9%
729	Esotropia	1.9%
730	Exotropia	1.9%
731	Hypotension, Orthostatic	1.9%
732	Sleep Apnea Syndromes	1.9%
733	Polymyositis	1.9%
734	Post-Exercise Hypotension	1.9%
735	Diverticulitis	1.9%
736	Disorders of Excessive Somnolence	1.9%
737	Sleep Initiation and Maintenance Disorders	1.9%
738	Night Terrors	1.9%
739	Somnambulism	1.9%
740	Trigeminal Nerve Disorder	1.9%
741	Transient Insomnia	1.9%
742	Sleep Paralysis	1.9%
743	Chronic Insomnia	1.9%
744	REM Sleep Behavior Disorder	1.9%
745	Hypersomnia	1.9%
746	Dermal Sinus	1.9%
747	Dysgeusia	1.9%
748	Formication	1.9%
749	Hyperalgesia	1.9%
750	Hyperesthesia	1.9%
751	Hypesthesia	1.9%
752	Language Disorders	1.9%
753	Numbness	1.9%
754	Paresthesia	1.9%
755	Paraparesis, Spastic	1.9%
756	Spina Bifida Cystica	1.9%
757	Trismus	1.9%
758	Spina Bifida Occulta	1.9%
759	Epilepsia Partialis Continua	1.9%
760	Hypogeusia	1.9%
761	Meningeal Carcinomatosis	1.9%
762	Brown-Sequard Syndrome	1.9%
763	Lissencephaly	1.9%
764	Polymicrogyria	1.9%
765	Pachygyria	1.9%
766	Schizencephaly	1.9%
767	Lockjaw	1.9%
768	Allodynia	1.9%
769	Lead Poisoning, Nervous System, Childhood	1.9%
770	Lead Poisoning, Nervous System, Adult	1.9%
771	Periventricular Nodular Heterotopia	1.9%
772	Ageusia	1.9%
773	Aicardi's syndrome	1.8%
774	Hoarseness	1.8%
775	Cockayne Syndrome	1.8%
776	Alcohol Withdrawal Delirium	1.8%
777	Alexia	1.8%
778	Dyslexia	1.8%
779	Optic Atrophy, Hereditary, Leber	1.8%
780	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.7%
781	Zellweger Syndrome	1.7%
782	Kearns-Sayre syndrome	1.7%
783	Eye Injuries	1.7%
784	Lung Abscess	1.7%
785	Muscular Dystrophy	1.6%
786	Congenital nystagmus	1.6%
787	Orbital Myositis	1.6%
788	Holoprosencephaly	1.6%
789	Diverticulum	1.6%
790	Diverticulosis	1.6%
791	Diplopia	1.6%
792	Muscle Rigidity	1.6%
793	Muscle Spasticity	1.6%
794	Scotoma	1.6%
795	Photophobia	1.6%
796	Cogwheel Rigidity	1.6%
797	Hemifacial Spasm	1.6%
798	Amaurosis	1.6%
799	Blindness	1.6%
800	Nuchal Rigidity	1.6%
801	Agnosia	1.6%
802	Apraxias	1.6%
803	Hallucinations	1.6%
804	Hemianopsia	1.6%
805	Hyperacusis	1.6%
806	Tinnitus	1.6%
807	Visual Agnosia	1.6%
808	Anosognosia	1.6%
809	Wernicke-Korsakoff Syndrome	1.6%
810	Phonophobia	1.6%
811	Hearing Loss	1.6%
812	Discitis	1.6%
813	Mastoiditis	1.6%
814	Petrositis	1.6%
815	Sarcopenia	1.6%
816	Polyradiculopathy	1.6%
817	Glycogen storage disease type II	1.6%
818	Neurofibrosarcoma	1.6%
819	Amnesia	1.4%
820	Delirium	1.4%
821	Dissociative Amnesia	1.4%
822	Color blindness	1.4%
823	Global Amnesia	1.4%
824	Cri-du-Chat Syndrome	1.4%
825	Down Syndrome	1.4%
826	Retropharyngeal Abscess	1.4%
827	Trisomy 21	1.4%
828	POEMS Syndrome	1.4%
829	Meningioma	1.4%
830	Williams Syndrome	1.4%
831	Microcephaly	1.4%
832	Macrocephaly	1.4%
833	Peritonsillar Abscess	1.4%
834	Hypokalemic periodic paralysis	1.4%
835	Porencephaly	1.4%
836	Liver Abscess	1.4%
837	Sleep Apnea, Obstructive	1.3%
838	Sleep Apnea, Central	1.3%
839	Narcolepsy	1.3%
840	Trigeminal Neuralgia	1.3%
841	Kleine-Levin Syndrome	1.3%
842	Agraphia	1.3%
843	Anomia	1.3%
844	Cluttering	1.3%
845	Language Development Disorders	1.3%
846	Speech Disorders	1.3%
847	Syncope	1.3%
848	Stupor	1.3%
849	Dysgraphia	1.3%
850	Presyncope	1.3%
851	Dyslalia	1.3%
852	Gaucher Disease	1.3%
853	Aspergillosis, Allergic Bronchopulmonary	1.3%
854	Prader-Willi Syndrome	1.3%
855	Phantom pain	1.3%
856	Phantom Limb Pain	1.3%
857	Eye Burns	1.2%
858	Welander Distal Myopathy	1.1%
859	Amaurosis Fugax	1.1%
860	Blindness, Cortical	1.1%
861	Dyscalculia	1.1%
862	Rett Syndrome	1.1%
863	Deafness	1.1%
864	Hearing Loss, Sudden	1.1%
865	Gerstmann Syndrome	1.1%
866	Hearing Loss, Bilateral	1.1%
867	Hearing Loss, High-Frequency	1.1%
868	Hearing Loss, Mixed Conductive-Sensorineural	1.1%
869	Prosopagnosia	1.1%
870	Apraxia, Ideomotor	1.1%
871	Charles Bonnet Syndrome	1.1%
872	Hearing Loss, Unilateral	1.1%
873	Complete Hearing Loss	1.1%
874	Alien Hand Syndrome	1.1%
875	Deaf Mutism	1.1%
876	Tay-Sachs Disease	1.1%
877	Niemann-Pick Disease, Type C	1.1%
878	Cataplexy	1.1%
879	Aphasia	1.1%
880	Articulation Disorders	1.1%
881	Echolalia	1.1%
882	Stuttering	1.1%
883	Dysphasia	1.1%
884	Rubinstein-Taybi Syndrome	1%
885	Dermatomyositis	1%
886	Corneal Scar	1%
887	Muscular Dystrophy, Duchenne	1%
888	Retrograde amnesia	1%
889	Amnesia, Anterograde	1%
890	Dysarthria	0.9%
891	Mutism	0.9%
892	Selective Mutism	0.9%
893	Fragile X Syndrome	0.9%
894	Corneal Perforation	0.8%
895	Alexia, Pure	0.8%
896	Liver Abscess, Amebic	0.7%
897	Mucopolysaccharidosis II	0.7%

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