MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Gigantism

(UMLS:C0017547)

Definition:: The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
UMLS ID:: C0017547
MeSH ID:: D005877

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.492|C05.116.132.479

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.700.355.528

Synonym(s)

Gigantism

GIGANTISM

Genetic giant

Giant

Giant, NOS

Giant, genetic

Giantism

Giantism, NOS

Gigantism, NOS

10.

Gigantosoma

11.

Normal giant

12.

Pituitary Gigantism

13.

Pituitary gigantism

14.

Primordial giant

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Octreotide	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Acromegaly	37.4%
2	Platybasia	34.1%
3	Congenital Hypothyroidism	33.5%
4	Dysostoses	33.3%
5	Osteoarthropathy, Secondary Hypertrophic	32.9%
6	Hyperostosis	30.5%
7	Osteitis	30.5%
8	Osteitis Deformans	30.5%
9	Osteochondrosis	30.5%
10	Spinal Diseases	30.5%
11	Pectus excavatum	29.2%
12	Dwarfism	29.1%
13	Osteochondritis	27.3%
14	Pectus carinatum	27.1%
15	Multiple Epiphyseal Dysplasia	27%
16	Osteochondrodysplasias	27%
17	Spinal Neoplasms	26.7%
18	Spondylitis	26.7%
19	Chondrodysplasia Punctata	24.8%
20	Enchondromatosis	24.8%
21	Osteosclerosis	24.8%
22	Kashin-Beck Disease	24.8%
23	Bone Diseases, Infectious	24.7%
24	Bone neoplasms	24.7%
25	Osteopenia	24.7%
26	Bone Resorption	24.3%
27	Aseptic Necrosis of Bone	24.3%
28	Klippel-Feil Syndrome	23.5%
29	Synostosis	23.5%
30	Craniofacial Dysostosis	20.9%
31	Melorheostosis	20.6%
32	Osteopetrosis	20.6%
33	Ainhum	20%
34	Spinal Stenosis	20%
35	Spondylosis	20%
36	Intervertebral Disc Degeneration	20%
37	Bone Diseases, Endocrine	19.7%
38	Discitis	19.7%
39	Hyperprolactinemia	18.5%
40	Arthrogryposis	17.6%
41	Fasciitis	17.5%
42	Foot Deformities	17.5%
43	Arthropathy	17.5%
44	Acrocephalosyndactylia	17.1%
45	Craniosynostosis	16.8%
46	Syndactyly	16.8%
47	Brachycephaly	16.8%
48	Osteogenesis Imperfecta	16.8%
49	Tuberculosis, Spinal	16.8%
50	Contracture	16.4%
51	Fasciitis, Plantar	16.4%
52	Osteoarthritis, Spine	16.4%
53	Osteomyelitis	16%
54	Osteoporosis	16%
55	Periostitis	16%
56	Bone Demineralization, Pathologic	16%
57	Post-Traumatic Osteoporosis	16%
58	Alveolar Bone Loss	15.9%
59	Femur Head Necrosis	15.9%
60	Osteolysis	15.9%
61	Bone Diseases, Developmental	15.3%
62	Eosinophilic Granuloma	14.9%
63	Lordosis	14.9%
64	Spondylolysis	14.9%
65	kyphosis	14.9%
66	Goldenhar Syndrome	14.9%
67	Jaw Diseases	14.5%
68	Mandibulofacial Dysostosis	14.5%
69	Ankylosing spondylitis	14.5%
70	Cartilage Diseases	14.1%
71	Foot Diseases	14.1%
72	Myopathy	14.1%
73	Rheumatism	14.1%
74	Chondromalacia	14.1%
75	Poland Syndrome	14%
76	Spondylarthropathies	13.8%
77	Fibromyalgia	13.6%
78	Polymyalgia Rheumatica	13.6%
79	Metatarsalgia	13.6%
80	Antley-Bixler Syndrome Phenotype	13.5%
81	Marfan Syndrome	13.5%
82	Gigantism	13.3%
83	Joint Tuberculosis	13.2%
84	Tuberculosis, Osteoarticular	13.2%
85	Bone Tuberculosis	13.2%
86	Basal Cell Nevus Syndrome	12.6%
87	Rubinstein-Taybi Syndrome	12.5%
88	Arthritis, Psoriatic	12.4%
89	Spondylolisthesis	12.3%
90	Empty Sella Syndrome	12%
91	Hypopituitarism	12%
92	Hypophysitis	12%
93	Osteoporosis, Postmenopausal	11.8%
94	Gout	11.7%
95	Arthritis, Reactive	11.4%
96	Ischemic contracture	11.4%
97	Rickets	11.3%
98	Rheumatic Fever	11.2%
99	Temporomandibular Joint Disorders	11.1%
100	Cockayne Syndrome	11.1%
101	Hip Contracture	10.7%
102	Periarthritis	10.7%
103	Arthritis	10.2%
104	Bursitis	10.2%
105	Joint Instability	10.2%
106	Myofascial Pain Syndromes	10.2%
107	Rhabdomyolysis	10.2%
108	Synovitis	10.2%
109	Joint laxity	10.2%
110	Polyarthritis	10.2%
111	Frozen shoulder	10.2%
112	Patellofemoral Pain Syndrome	10.2%
113	Diabetes Insipidus	10.1%
114	Temporomandibular Joint Dysfunction Syndrome	9.9%
115	Pseudohypoparathyroidism	9.9%
116	Talipes	9.8%
117	Mastoiditis	9.8%
118	Petrositis	9.8%
119	Rheumatoid Arthritis	9.7%
120	Juvenile arthritis	9.7%
121	Osteoarthritis, Knee	9.3%
122	Adrenal Gland Diseases	8.8%
123	Gonadal Disorders	8.8%
124	Parathyroid Diseases	8.8%
125	Thyroid Diseases	8.8%
126	Pituitary Apoplexy	8.5%
127	Palatal Neoplasms	8.4%
128	Osteomalacia	8.4%
129	Compartment syndromes	8.2%
130	Maxillary Diseases	8.2%
131	Tendinitis	8.2%
132	Tendinopathy	8.2%
133	Arthritis, Gouty	8.2%
134	Hemarthrosis	8.1%
135	Myositis	8.1%
136	Tietze's Syndrome	8.1%
137	Limb Deformities, Congenital	8.1%
138	Isaacs syndrome	8.1%
139	Craniofacial Abnormalities	8.1%
140	Myotonic Disorders	8.1%
141	Rheumatoid Nodule	7.7%
142	Congenital clubfoot	7.7%
143	Vertical Talus	7.7%
144	Pituitary Adenoma	7.2%
145	Pituitary Neoplasms	7.2%
146	Endocrine Gland Neoplasms	7%
147	Diabetes Mellitus	6.9%
148	Renal Osteodystrophy	6.8%
149	Renal rickets	6.8%
150	Adrenal Gland Neoplasms	6.8%
151	Medial Tibial Stress Syndrome	6.8%
152	Mitochondrial Myopathies	6.7%
153	Muscle Cramp	6.7%
154	Eosinophilia-Myalgia Syndrome	6.7%
155	Gastroschisis	6.7%
156	Jaw Abnormalities	6.7%
157	Bunion	6.7%
158	Fibrodysplasia Ossificans Progressiva	6.7%
159	Myoglobinuria	6.7%
160	Myositis Ossificans	6.7%
161	Tenosynovitis	6.7%
162	Sacroiliitis	6.7%
163	Muscle Rigidity	6.6%
164	Muscle Spasticity	6.6%
165	Cogwheel Rigidity	6.6%
166	Nuchal Rigidity	6.6%
167	Felty Syndrome	6.6%
168	Prolactinoma	6.6%
169	Growth Hormone-Secreting Pituitary Adenoma	6.6%
170	Prognathism	6.3%
171	Nose Neoplasms	6.1%
172	Chronic Fatigue Syndrome	6%
173	Nail-Patella Syndrome	5.8%
174	Parathyroid Neoplasms	5.8%
175	Thyroid Neoplasm	5.8%
176	Thyroid carcinoma	5.8%
177	Giant Cell Epulis	5.8%
178	Muscle Weakness	5.8%
179	Rheumatoid Vasculitis	5.8%
180	Musculoskeletal Pain	5.7%
181	Familial Periodic Paralysis	5.7%
182	Arthralgia	5.7%
183	Polyarthralgia	5.7%
184	Nelson Syndrome	5.6%
185	Arthritis, Infectious	5.4%
186	Anterior Compartment Syndrome	5.3%
187	Enthesopathy	5.3%
188	Arthritis, Experimental	5.3%
189	Abdominal Compartment Syndrome	5.3%
190	Amelia	5.3%
191	Arachnodactyly	5.3%
192	Ectromelia	5.3%
193	Hemimelia	5.3%
194	Phocomelia	5.3%
195	Sirenomelia	5.3%
196	Polymyositis	5.3%
197	Polydactyly	5.3%
198	Brachydactyly	5.3%
199	Plagiocephaly	5.3%
200	Lower Extremity Deformities, Congenital	5.3%
201	Upper Extremity Deformities, Congenital	5.3%
202	Sicca Syndrome	5.1%
203	Laryngomalacia	5.1%
204	Sjogren's Syndrome	5.1%
205	Adrenal Cortex Diseases	5.1%
206	Euthyroid Sick Syndromes	5.1%
207	Goiter	5.1%
208	Hyperparathyroidism	5.1%
209	Hyperthyroidism	5.1%
210	Hyperthyroxinemia	5.1%
211	Hypogonadism	5.1%
212	Hypoparathyroidism	5.1%
213	Hypothyroidism	5.1%
214	Delayed Puberty	5.1%
215	Precocious Puberty	5.1%
216	Thyroiditis	5.1%
217	Hypogonadotropic hypogonadism	5.1%
218	Testotoxicosis	5.1%
219	Secondary hypothyroidism	5.1%
220	Primary Hyperthyroidism	5.1%
221	Primary Hypothyroidism	5.1%
222	Myalgia	5%
223	Micrognathism	4.7%
224	Pierre Robin Syndrome	4.7%
225	Myotonic Dystrophy	4.6%
226	Hip Dislocation	4.5%
227	Shoulder Dislocation	4.5%
228	Hip Dysplasia	4.5%
229	Muscular Dystrophy	4.5%
230	Orbital Myositis	4.5%
231	Dupuytren Contracture	4.5%
232	Pyomyositis	4.4%
233	Retrognathia	4.3%
234	ovarian neoplasm	4.2%
235	Testicular Diseases	4.1%
236	Ovarian Diseases	4%
237	Graves Disease	3.8%
238	Maxillofacial Abnormalities	3.8%
239	Myotonia Congenita	3.8%
240	Thyroid Nodule	3.8%
241	Bronchomalacia	3.8%
242	Tracheomalacia	3.8%
243	Microcephaly	3.7%
244	Macrocephaly	3.7%
245	Hypokalemic periodic paralysis	3.7%
246	Shoulder Pain	3.7%
247	Testicular Neoplasms	3.7%
248	Adrenocortical carcinoma	3.7%
249	Cleft Palate	3.5%
250	Gestational Diabetes	3.4%
251	Latent Autoimmune Diabetes in Adults	3.4%
252	Diabetes Mellitus, Experimental	3.4%
253	Cushing Syndrome	3.3%
254	Hyperaldosteronism	3.3%
255	Hyperparathyroidism, Secondary	3.3%
256	Hypoaldosteronism	3.3%
257	Thyrotoxicosis	3.3%
258	Hyperparathyroidism, Primary	3.3%
259	Thyroid Hormone Resistance Syndrome	3.3%
260	Mitochondrial Encephalomyopathies	3.3%
261	Welander Distal Myopathy	3.3%
262	Familial Hypophosphatemic Rickets	3.2%
263	Noonan Syndrome	3%
264	Hermaphroditism	2.9%
265	Disorders of Sex Development	2.9%
266	Dermatomyositis	2.9%
267	Muscular Dystrophy, Duchenne	2.8%
268	Diabetic Foot	2.8%
269	Porencephaly	2.8%
270	Addison Disease	2.7%
271	Diabetic Angiopathies	2.7%
272	Autoimmune thyroiditis	2.7%
273	Primary Adrenal Insufficiency	2.7%
274	Diabetic Neuropathies	2.7%
275	Myxedema	2.7%
276	Orchitis	2.7%
277	Diabetic Amyotrophy	2.7%
278	Diabetic Autonomic Neuropathy	2.7%
279	Diabetic Cardiomyopathies	2.7%
280	Holoprosencephaly	2.6%
281	Ovarian Hyperstimulation Syndrome	2.6%
282	Multiple Endocrine Neoplasia	2.6%
283	Pancreatic Neoplasm	2.6%
284	Kallmann Syndrome	2.6%
285	granulosa cell tumor	2.5%
286	Carcinoma, Ovarian Epithelial	2.5%
287	Hyperglycemic Hyperosmolar Nonketotic Coma	2.5%
288	Hashimoto Disease	2.5%
289	Klinefelter Syndrome	2.3%
290	Corpus Luteum Cyst	2.2%
291	Ovarian Cysts	2.2%
292	Diabetic Nephropathy	2.2%
293	Anovulation	2.2%
294	Diabetic Ketoacidosis	2.2%
295	Oophoritis	2.2%
296	Radicular Cyst	2%
297	Cryptorchidism	1.9%
298	Gonadal Dysgenesis	1.9%
299	Adrenogenital Syndrome	1.9%
300	Ovotesticular Disorders of Sex Development	1.9%
301	Leydig Cell Tumor	1.8%
302	Hyperandrogenism	1.8%
303	Diabetic Retinopathy	1.7%
304	Multiple Endocrine Neoplasia Type 1	1.7%
305	Polycystic Ovary Syndrome	1.6%
306	MELAS Syndrome	1.6%
307	Kearns-Sayre syndrome	1.5%
308	Carcinoma, Pancreatic Ductal	1.3%
309	Turner Syndrome	1.2%
310	Waterhouse-Friderichsen Syndrome	1.1%
311	insulinoma	1.1%
312	Gastrinoma	1.1%
313	Glucagonoma	1.1%
314	Carcinoma, Endometrioid	1.1%
315	Vipoma	1%
316	Adrenoleukodystrophy	0.7%
317	Denys-Drash Syndrome	0.6%

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