MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Alstrom Syndrome

(UMLS:C0268425)

Definition:: Rare autosomal recessive disease characterized by multiple organ dysfunction. The key clinical features include retinal degeneration (NYSTAGMUS, PATHOLOGIC; RETINITIS PIGMENTOSA; and eventual blindness), childhood obesity, sensorineural hearing loss, and normal mental development. Endocrinologic complications include TYPE 2 DIABETES MELLITUS; HYPERINSULINEMIA; ACANTHOSIS NIGRICANS; HYPOTHYROIDISM; and progressive renal and hepatic failures. The disease is caused by mutations in the ALMS1 gene.
UMLS ID:: C0268425
MeSH ID:: D056769

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.300.099|C10.574.500.495.099|C10.668.829.800.300.099

Classification 2:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.270.684.249

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.245.063|C16.131.666.300.099|C16.320.184.063|C16.320.290.684.249|C16.320.400.375.099

Synonym(s)

Alstrom Syndrome

ALSTROM SYNDROME

Alstroem syndrome

Alstrom syndrome

Alstrom's syndrome

Alstr枚m Syndrome

alstrom syndrome

alstrom's syndrome

alstroms syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Metformin		18038714	CTD
2	Rosiglitazone		18038714	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Charcot-Marie-Tooth Disease	45.2%
2	Aicardi's syndrome	42.4%
3	Refsum Disease	40.5%
4	Holoprosencephaly	34.3%
5	Cockayne Syndrome	33.1%
6	Smith-Magenis syndrome	30.3%
7	CHARGE Syndrome	30.2%
8	Kartagener Syndrome	29.7%
9	Tuberous Sclerosis	29.6%
10	Beckwith-Wiedemann Syndrome	28.4%
11	Wolf-Hirschhorn Syndrome	28.4%
12	Cri-du-Chat Syndrome	27.8%
13	Down Syndrome	27.8%
14	Trisomy 21	27.8%
15	Rubinstein-Taybi Syndrome	26.5%
16	Myotonic Dystrophy	26.1%
17	Albinism	26.1%
18	Prader-Willi Syndrome	25.8%
19	Retinal Dysplasia	25.2%
20	Nail-Patella Syndrome	25%
21	Fragile X Syndrome	24.8%
22	Primary Ciliary Dyskinesia	24.6%
23	Aniridia	24.6%
24	Ectodermal Dysplasia	24.4%
25	Aplasia Cutis Congenita	24.4%
26	Marfan Syndrome	24.2%
27	Hepatolenticular Degeneration	23.9%
28	Ichthyosis, X-Linked	23.9%
29	Amyloid Neuropathies, Familial	23.6%
30	Polycystic Kidney Diseases	23.1%
31	Dystonia Musculorum Deformans	22.2%
32	Neuronal Ceroid-Lipofuscinoses	22.1%
33	Dural Arteriovenous Fistula	21.9%
34	Canavan Disease	21.7%
35	Alexander Disease	21.7%
36	Myasthenic Syndromes, Congenital	21.7%
37	Cystic Fibrosis	21.6%
38	Myotonia Congenita	21.4%
39	Optic Atrophy, Hereditary, Leber	21.2%
40	Lafora Disease	20.8%
41	Unverricht-Lundborg Syndrome	20.8%
42	Duane Retraction Syndrome	20.8%
43	Dandy-Walker Syndrome	20.3%
44	Adrenoleukodystrophy	20.2%
45	Hydranencephaly	20.2%
46	Neural Tube Defects	20.2%
47	Tethered Cord Syndrome	20.2%
48	Iniencephaly	20.2%
49	Craniorachischisis	20.2%
50	Exencephaly	20.2%
51	Septo-Optic Dysplasia	20.2%
52	Cortical Dysplasia	20.2%
53	Malformations of Cortical Development	20.2%
54	Menkes Kinky Hair Syndrome	20.1%
55	Muscular Dystrophy, Duchenne	19.8%
56	Anencephaly	19.7%
57	Classical Lissencephalies and Subcortical Band Heterotopias	19.7%
58	Smith-Lemli-Opitz Syndrome	19.5%
59	Central Nervous System Cysts	19.5%
60	Mucopolysaccharidosis II	19.4%
61	Mobius Syndrome	19.1%
62	Huntington Disease	19.1%
63	Muscular Dystrophy	18.5%
64	Alstrom Syndrome	18.4%
65	Anemia, Sickle Cell	18.1%
66	Thalassemia	18.1%
67	Williams Syndrome	17.7%
68	Neoplastic Syndromes, Hereditary	17.7%
69	Multiple Epiphyseal Dysplasia	17.3%
70	Osteochondrodysplasias	17.3%
71	Pelger-Huet Anomaly	17.3%
72	Werner Syndrome	17.3%
73	Eye Abnormalities	17%
74	Rett Syndrome	17%
75	Ataxia Telangiectasia	16.9%
76	POEMS Syndrome	16.9%
77	Sjogren-Larsson Syndrome	16.4%
78	Zellweger Syndrome	16.3%
79	Dwarfism	16.2%
80	Polycystic Kidney, Autosomal Dominant	15.9%
81	Osteogenesis Imperfecta	15.9%
82	Kallmann Syndrome	15.8%
83	Wiskott-Aldrich Syndrome	15.7%
84	Abnormalities, Drug-Induced	15.1%
85	Situs Inversus	15.1%
86	Motor Neuron Disease	15%
87	Epidermolysis Bullosa	15%
88	Polyradiculoneuropathy	14.9%
89	Polyradiculoneuritis	14.9%
90	Autoimmune Lymphoproliferative Syndrome	14.8%
91	Friedreich Ataxia	14.6%
92	Angioedemas, Hereditary	14.6%
93	Guillain-Barre Syndrome	14.6%
94	Fabry Disease	14.5%
95	Fetal Diseases	14%
96	Cardiovascular Abnormalities	14%
97	Skin Abnormalities	13.8%
98	Lymphatic Abnormalities	13.8%
99	Congenital Microtia	13.8%
100	Basal Cell Nevus Syndrome	13.8%
101	Congenital diaphragmatic hernia	13.7%
102	Xeroderma	13.7%
103	Meningomyelocele	13.2%
104	Spina Bifida	13.2%
105	Pseudoxanthoma Elasticum	13.2%
106	Prune Belly Syndrome	13.1%
107	Waardenburg Syndrome	13.1%
108	Microcephaly	13%
109	Macrocephaly	13%
110	Urogenital Abnormalities	12.9%
111	Multiple System Atrophy	12.9%
112	Amyotrophic Lateral Sclerosis	12.9%
113	Stiff-Person Syndrome	12.6%
114	Miller Fisher Syndrome	12.5%
115	Sickle Cell Trait	12.5%
116	Xeroderma Pigmentosum	12.4%
117	Meconium Aspiration Syndrome	12.4%
118	Meningocele	12.1%
119	Encephalocele	12.1%
120	Turner Syndrome	12%
121	Complex Regional Pain Syndromes	12%
122	Subacute Combined Degeneration	11.9%
123	Bloom Syndrome	11.9%
124	Maxillofacial Abnormalities	11.9%
125	Galactosemias	11.9%
126	Urea Cycle Disorders, Inborn	11.9%
127	Tyrosinemias	11.9%
128	Glycogen storage disease type II	11.9%
129	Porencephaly	11.8%
130	Dextrocardia	11.8%
131	Familial Mediterranean Fever	11.7%
132	Welander Distal Myopathy	11.7%
133	Ocular Motility Disorders	11.5%
134	Cyclophoria	11.5%
135	Blepharophimosis	11%
136	Peripheral Nerve Injuries	11%
137	Causalgia	11%
138	Acute Chest Syndrome	10.9%
139	Hyperkeratosis, Epidermolytic	10.9%
140	Abnormalities, Radiation-Induced	10.8%
141	Spinal Muscular Atrophy	10.8%
142	Progressive Muscular Atrophy	10.8%
143	Ophthalmoplegic Migraine	10.7%
144	Amino Acid Metabolism, Inborn Errors	10.7%
145	Carbohydrate Metabolism, Inborn Errors	10.7%
146	Metal Metabolism, Inborn Errors	10.7%
147	Progeria	10.7%
148	Lysosomal Storage Diseases	10.7%
149	Cytochrome-c Oxidase Deficiency	10.7%
150	Peroxisomal Disorders	10.7%
151	Brain Diseases, Metabolic, Inborn	10.7%
152	Prion Diseases	10.5%
153	Scimitar Syndrome	10.4%
154	Restless Legs Syndrome	10.3%
155	Antley-Bixler Syndrome Phenotype	10.2%
156	Cauda Equina Syndrome	10.2%
157	Anophthalmos	10.2%
158	Microphthalmos	10.2%
159	Lewy Body Disease	10.2%
160	Hyperphosphaturia	10.1%
161	Parkinson Disease	10.1%
162	Homocystinuria	10.1%
163	Leigh Disease	10%
164	Lambert-Eaton Myasthenic Syndrome	10%
165	Congenital nystagmus	10%
166	Familial Periodic Paralysis	10%
167	Progressive supranuclear palsy	9.9%
168	Cutis Laxa	9.9%
169	Acrocephalosyndactylia	9.8%
170	Porokeratosis	9.8%
171	Keratoderma, Palmoplantar	9.8%
172	Klinefelter Syndrome	9.8%
173	Chronic granulomatous disease	9.8%
174	Dermal Sinus	9.7%
175	Spina Bifida Cystica	9.7%
176	Spina Bifida Occulta	9.7%
177	Lissencephaly	9.7%
178	Polymicrogyria	9.7%
179	Pachygyria	9.7%
180	Schizencephaly	9.7%
181	Periventricular Nodular Heterotopia	9.7%
182	Opsoclonus-Myoclonus Syndrome	9.7%
183	Gaucher Disease	9.6%
184	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9.5%
185	Poliomyelitis	9.4%
186	Deformity	9.3%
187	Brachial Plexus Neuritis	9.2%
188	Neuralgic Amyotrophy	9.2%
189	Cranial nerve diseases	9.2%
190	Demyelinating Diseases	9.2%
191	Demyelination	9.2%
192	Chronobiology Disorders	9.2%
193	Twins, Conjoined	9.1%
194	Myelitis, Transverse	9.1%
195	Porphyrias, Hepatic	9.1%
196	Peutz-Jeghers Syndrome	9.1%
197	Thrombasthenia	9.1%
198	Antithrombin III Deficiency	9.1%
199	Protein C Deficiency	9.1%
200	Afibrinogenemia	9%
201	Factor VII Deficiency	9%
202	Factor X Deficiency	9%
203	Factor XII Deficiency	9%
204	Hemophilia A	9%
205	Activated Protein C Resistance	9%
206	Factor II deficiency	9%
207	Factor VIII Deficiency	9%
208	Factor V deficiency	9%
209	Factor XI Deficiency	9%
210	Hypoprothrombinemias	9%
211	Fanconi Anemia	9%
212	Mucopolysaccharidosis III	9%
213	Anemia, Diamond-Blackfan	9%
214	Progressive bulbar palsy	8.9%
215	Bulbar palsy	8.9%
216	Craniosynostosis	8.8%
217	Syndactyly	8.8%
218	Brachycephaly	8.8%
219	Chronic Fatigue Syndrome	8.8%
220	Carbamoyl-Phosphate Synthase I Deficiency Disease	8.7%
221	Multiple Endocrine Neoplasia	8.6%
222	Abdominal Cramps	8.5%
223	Amniotic Band Syndrome	8.5%
224	Asphyxia Neonatorum	8.5%
225	Infant, Premature, Diseases	8.5%
226	Infantile Colic	8.5%
227	Trauma, Nervous System	8.5%
228	Congenital Hypothyroidism	8.5%
229	Tay-Sachs Disease	8.5%
230	Toxoplasmosis, Congenital	8.4%
231	Dermatitis, Atopic	8.4%
232	Behcet Syndrome	8.4%
233	Acrodynia	8.4%
234	Striatonigral Degeneration	8.4%
235	Niemann-Pick Disease, Type C	8.4%
236	Tauopathies	8.4%
237	Nervous System Neoplasms	8.4%
238	Neurologic Manifestations	8.4%
239	Neurotoxicity Syndromes	8.4%
240	Anus, Imperforate	8.4%
241	Limb Deformities, Congenital	8.4%
242	Craniofacial Abnormalities	8.4%
243	Anorectal Malformations	8.4%
244	Noonan Syndrome	8.3%
245	Cleft Palate	8.3%
246	Myasthenia Gravis	8.2%
247	Retinitis Pigmentosa	8.2%
248	Pigmentary retinopathy	8.2%
249	Neuromyelitis Optica	8.1%
250	Neuromuscular Junction Diseases	8%
251	Meningoencephalitis	8%
252	Neuritis	8%
253	Polyneuritis	8%
254	Radiculitis	8%
255	Mononeuritis	8%
256	Mononeuropathies	8%
257	Brachial Plexus Neuropathies	8%
258	Radiculopathy	8%
259	Mononeuropathy Multiplex	8%
260	Nerve Root Compression	8%
261	Leukoencephalitis, Acute Hemorrhagic	7.9%
262	Tarsal Tunnel Syndrome	7.8%
263	Shy-Drager Syndrome	7.8%
264	Anemia, Neonatal	7.8%
265	Persistent Fetal Circulation Syndrome	7.8%
266	Optic Neuropathy	7.8%
267	Sleep Wake Disorders	7.8%
268	Umbilical hernia	7.7%
269	Laryngostenosis	7.7%
270	Mouth Abnormalities	7.7%
271	Esophageal Atresia	7.7%
272	Intestinal Atresia	7.7%
273	Horseshoe Kidney	7.7%
274	Pectus excavatum	7.7%
275	Klippel-Feil Syndrome	7.7%
276	Gastroschisis	7.7%
277	Synostosis	7.7%
278	Acrodermatitis	7.6%
279	Lymphangiectasis, Intestinal	7.6%
280	Gianotti-Crosti Syndrome	7.6%
281	Botulism	7.6%
282	MELAS Syndrome	7.5%
283	Encephalomyelitis	7.5%
284	Autonomic Dysreflexia	7.5%
285	Myopathy	7.5%
286	Reflex Sympathetic Dystrophy	7.4%
287	Alkaptonuria	7.4%
288	Glycogen Storage Disease	7.4%
289	Hypophosphatasia	7.4%
290	Propionic acidemia	7.4%
291	Dihydropyrimidine Dehydrogenase Deficiency	7.4%
292	Cystinosis	7.4%
293	Jaw Abnormalities	7.3%
294	Isaacs syndrome	7.3%
295	Diabetic Neuropathies	7.3%
296	Diabetic Amyotrophy	7.3%
297	Diabetic Autonomic Neuropathy	7.3%
298	Leukomalacia, Periventricular	7.3%
299	Hydrops Fetalis	7.3%
300	Neuralgia	7.3%
301	Neuropathic pain	7.3%
302	Hypokalemic periodic paralysis	7.2%
303	Retinal Degeneration	7.2%
304	Neonatal Abstinence Syndrome	7.2%
305	Carpal Tunnel Syndrome	7.2%
306	Arthrogryposis	7.2%
307	Choanal Atresia	7.2%
308	Tracheobronchomegaly	7.2%
309	Laryngocele	7.2%
310	Pneumocephalus	7.2%
311	Sciatica	7.2%
312	Choledochal Cyst	7.1%
313	Hermaphroditism	7.1%
314	Disorders of Sex Development	7.1%
315	Fetal Growth Retardation	7.1%
316	Fetal Hypoxia	7.1%
317	Fetal Alcohol Spectrum Disorders	7.1%
318	Pupil Disorders	7.1%
319	Cryptorchidism	7.1%
320	Hypospadias	7.1%
321	Syphilis, Congenital	7.1%
322	Paraneoplastic Encephalomyelitis	7%
323	Spinal Cord Injuries	7%
324	Ophthalmia Neonatorum	6.9%
325	Dyskinesia, Drug-Induced	6.9%
326	Nephroblastoma	6.9%
327	Asterixis	6.9%
328	Ballismus	6.9%
329	Hand-Arm Vibration Syndrome	6.8%
330	Hypolipoproteinemias	6.8%
331	Papillon-Lefevre Disease	6.8%
332	Hyperlipidemia, Familial Combined	6.8%
333	Hyperlipoproteinemia Type III	6.8%
334	Poland Syndrome	6.7%
335	Laryngomalacia	6.7%
336	Leukoencephalopathy, Progressive Multifocal	6.6%
337	Limbic Encephalitis	6.6%
338	Pectus carinatum	6.6%
339	Mandibulofacial Dysostosis	6.6%
340	Congenital Hyperinsulinism	6.6%
341	Bladder Exstrophy	6.6%
342	Epispadias	6.6%
343	Retinopathy of Prematurity	6.6%
344	Chorioamnionitis	6.6%
345	Marchiafava-Bignami Disease	6.6%
346	Multicystic Dysplastic Kidney	6.6%
347	Horner Syndrome	6.5%
348	Adenomatous Polyposis Coli	6.5%
349	Sleep Disorders, Circadian Rhythm	6.4%
350	Epidural Abscess	6.4%
351	Olfactory Nerve Injuries	6.4%
352	Neuromuscular Diseases	6.3%
353	Ophthalmoplegia	6.3%
354	External Ophthalmoplegia	6.3%
355	Lactose Intolerance	6.3%
356	Neuritis, Autoimmune, Experimental	6.3%
357	Variegate Porphyria	6.3%
358	Acute intermittent porphyria	6.3%
359	Porphyria Cutanea Tarda	6.3%
360	Hyperhomocysteinemia	6.2%
361	Renal Aminoacidurias	6.2%
362	Fanconi Syndrome	6.2%
363	Pseudohypoaldosteronism	6.2%
364	Liddle Syndrome	6.2%
365	MPTP Poisoning	6.2%
366	Hyperlipoproteinemia Type IV	6.2%
367	Hyperlipoproteinemia Type V	6.2%
368	Myasthenia Gravis, Autoimmune, Experimental	6.2%
369	Color blindness	6.2%
370	Polyradiculopathy	6.2%
371	Lupus Vasculitis, Central Nervous System	6.1%
372	Denys-Drash Syndrome	6.1%
373	Neuroleptic Malignant Syndrome	6%
374	Scrapie	6%
375	Myelinolysis, Central Pontine	6%
376	Encephalomyelitis, Acute Disseminated	6%
377	Genetic Diseases, Inborn	6%
378	Presenile dementia	6%
379	Senile dementia	6%
380	Familial Hypophosphatemic Rickets	6%
381	Facial Nerve Injuries	6%
382	Cubital Tunnel Syndrome	5.9%
383	Akathisia, Drug-Induced	5.9%
384	Gout	5.9%
385	Multiple Endocrine Neoplasia Type 1	5.8%
386	Pseudohypoparathyroidism	5.8%
387	Renal tubular acidosis	5.8%
388	Micrognathism	5.8%
389	Pierre Robin Syndrome	5.8%
390	Glycogen Storage Disease Type I	5.7%
391	Glycogen Storage Disease Type V	5.7%
392	Myelitis	5.6%
393	Amelia	5.6%
394	Arachnodactyly	5.6%
395	Ectopia Cordis	5.6%
396	Ectromelia	5.6%
397	Hemimelia	5.6%
398	Phocomelia	5.6%
399	Sirenomelia	5.6%
400	Polydactyly	5.6%
401	Brachydactyly	5.6%
402	Plagiocephaly	5.6%
403	Lower Extremity Deformities, Congenital	5.6%
404	Upper Extremity Deformities, Congenital	5.6%
405	Single umbilical artery	5.6%
406	Amblyopia	5.5%
407	Paraneoplastic Cerebellar Degeneration	5.5%
408	Hyperandrogenism	5.5%
409	Retrognathia	5.4%
410	Vision Disorders	5.4%
411	Metamorphopsia	5.4%
412	Visual Impairment	5.4%
413	Uveomeningoencephalitic Syndrome	5.3%
414	Retinoblastoma	5.3%
415	Hypoalphalipoproteinemias	5.3%
416	Brain Injuries	5.2%
417	Vasculitis, Central Nervous System	5.2%
418	Aortic coarctation	5.2%
419	Brain Neoplasms	5.2%
420	Cor Triatriatum	5.2%
421	Coronary Vessel Anomalies	5.2%
422	Dental Enamel Hypoplasia	5.2%
423	Patent ductus arteriosus	5.2%
424	Ebstein Anomaly	5.2%
425	Heart Septal Defects	5.2%
426	Hypodontia	5.2%
427	Macrostomia	5.2%
428	Microstomia	5.2%
429	Multiple Sclerosis	5.2%
430	Spinal Cord Neoplasms	5.2%
431	Tetralogy of Fallot	5.2%
432	Transposition of Great Vessels	5.2%
433	Hypoplastic Left Heart Syndrome	5.2%
434	May-Thurner Syndrome	5.2%
435	Jet Lag Syndrome	5.2%
436	Craniofacial Dysostosis	5.2%
437	Wolff-Parkinson-White Syndrome	5.1%
438	Prognathism	5.1%
439	Brain Diseases	5.1%
440	Dysautonomia	5.1%
441	Meningitis	5.1%
442	Movement Disorders	5.1%
443	Pachymeningitis	5.1%
444	Spinal Cord Diseases	5.1%
445	Vagus Nerve Disorder	5.1%
446	Glossopharyngeal Neuralgia	5.1%
447	Abducens Nerve Diseases	5.1%
448	Heavy Metal Poisoning, Nervous System	5.1%
449	Trochlear Nerve Diseases	5.1%
450	Glycosuria, Renal	5.1%
451	Sciatic Neuropathy	5%
452	Ulnar Neuropathies	5%
453	Lesion of Sciatic Nerve	5%
454	Ulnar Neuritis	5%
455	Radial nerve compression	5%
456	Radial Tunnel Syndrome	5%
457	Peroneal Neuropathies	5%
458	Radial Neuropathy	5%
459	Median Neuropathy	5%
460	Sciatic Nerve Palsy	5%
461	Femoral Neuropathy	5%
462	Tibial Neuropathy	5%
463	Ulnar Nerve Palsy	5%
464	Radial nerve palsy	5%
465	Kernicterus	4.9%
466	Epilepsy, Post-Traumatic	4.9%
467	Cystinuria	4.8%
468	Optic Nerve Glioma	4.8%
469	Dementia, Vascular	4.8%
470	Brain Abscess	4.8%
471	Brain Hemorrhage, Traumatic	4.8%
472	Paralysis, Obstetric	4.8%
473	Long QT Syndrome	4.8%
474	Platybasia	4.8%
475	Tricuspid Atresia	4.8%
476	Arrhythmogenic Right Ventricular Dysplasia	4.8%
477	Gonadal Dysgenesis	4.8%
478	Bronchomalacia	4.8%
479	Adrenogenital Syndrome	4.8%
480	Tracheomalacia	4.8%
481	Ovotesticular Disorders of Sex Development	4.8%
482	Bronchopulmonary Dysplasia	4.7%
483	Subdural Effusion	4.7%
484	Parkinsonian Disorders	4.7%
485	Nocturnal Myoclonus Syndrome	4.7%
486	neurofibroma	4.7%
487	Central Nervous System Infection	4.7%
488	Facial Nerve Diseases	4.7%
489	Craniocerebral Trauma	4.7%
490	Parasomnia	4.7%
491	Dyssomnias	4.7%
492	Vestibulocochlear Nerve Diseases	4.6%
493	Decerebrate State	4.6%
494	Hemiparesis	4.6%
495	Meningism	4.6%
496	Optic Atrophy	4.6%
497	Optic Neuritis	4.6%
498	Papilledema	4.6%
499	Paresis	4.6%
500	Seizures	4.6%
501	Sensation Disorders	4.6%
502	Strabismus	4.6%
503	Tolosa-Hunt Syndrome	4.6%
504	Central Nervous System Neoplasms	4.6%
505	Complex partial seizures	4.6%
506	Monoparesis	4.6%
507	Neurogenic Inflammation	4.6%
508	Gait Disorders, Neurologic	4.6%
509	Neuromuscular Manifestations	4.6%
510	Sweating, Gustatory	4.6%
511	Thoracic Outlet Syndrome	4.6%
512	Auriculotemporal Syndrome	4.6%
513	Eye Injuries	4.6%
514	Arthritis, Gouty	4.5%
515	Vocal Cord Paralysis	4.5%
516	Respiratory Distress Syndrome, Newborn	4.4%
517	Central Cord Syndrome	4.4%
518	Meningitis, Bacterial	4.4%
519	Meningitis, Fungal	4.4%
520	Chorea	4.3%
521	Myositis	4.3%
522	Myotonic Disorders	4.3%
523	Neurobehavioral Manifestations	4.3%
524	Corneal Scar	4.3%
525	Optic Neuropathy, Ischemic	4.3%
526	Anterior Ischemic Optic Neuropathy	4.3%
527	Anisocoria	4.2%
528	Sturge-Weber Syndrome	4.2%
529	Tonic Pupil	4.2%
530	Vertigo	4.2%
531	Alcohol-Induced Disorders, Nervous System	4.2%
532	Orbital Myositis	4.2%
533	Carotid Artery Injuries	4.2%
534	Alcohol Withdrawal Seizures	4.1%
535	Cerebellar Neoplasms	4.1%
536	Cerebrospinal Fluid Otorrhea	4%
537	Cerebrospinal Fluid Rhinorrhea	4%
538	Nesidioblastosis	4%
539	Fibromyalgia	4%
540	Gait Ataxia	4%
541	Medial Tibial Stress Syndrome	4%
542	Mitochondrial Myopathies	4%
543	Voice Disorders	4%
544	Voice Disturbance	4%
545	Eosinophilia-Myalgia Syndrome	4%
546	Aortopulmonary Septal Defect	3.9%
547	Double Outlet Right Ventricle	3.9%
548	Endocardial Cushion Defects	3.9%
549	Myocardial bridging	3.9%
550	Aorticopulmonary Septal Defect	3.9%
551	Frontotemporal dementia	3.9%
552	Meige Syndrome	3.8%
553	Cerebral Ventriculitis	3.8%
554	Kearns-Sayre syndrome	3.8%
555	Tuberculosis, Meningeal	3.8%
556	Brain Death	3.7%
557	Coma, Post-Head Injury	3.7%
558	Mitochondrial Encephalomyopathies	3.7%
559	Alice in Wonderland Syndrome	3.7%
560	Akathisia	3.7%
561	Restlessness	3.7%
562	Psychomotor Agitation	3.7%
563	Toxoplasmosis, Cerebral	3.7%
564	Reflex, Abnormal	3.6%
565	Hyporeflexia	3.6%
566	Hyperreflexia	3.6%
567	Romano-Ward Syndrome	3.6%
568	Peripheral Nervous System Diseases	3.6%
569	Brain Concussion	3.6%
570	Pituitary Adenoma	3.6%
571	Pituitary Neoplasms	3.6%
572	Creutzfeldt-Jakob disease	3.5%
573	Basal Ganglia Cerebrovascular Disease	3.5%
574	Brain Injuries, Diffuse	3.5%
575	Traumatic Brain Injury	3.5%
576	Cerebellar Ataxia	3.5%
577	Supratentorial Neoplasms	3.5%
578	Torticollis	3.5%
579	Multiple Sclerosis, Chronic Progressive	3.5%
580	Multiple Sclerosis, Relapsing-Remitting	3.5%
581	Acoustic Neuroma	3.4%
582	Diplopia	3.4%
583	Scotoma	3.4%
584	Photophobia	3.4%
585	Amaurosis	3.4%
586	Blindness	3.4%
587	Posterior Leukoencephalopathy Syndrome	3.4%
588	Posterior reversible encephalopathy syndrome	3.4%
589	Myalgia	3.4%
590	Vertebral Artery Dissection	3.4%
591	Amnesia, Transient Global	3.4%
592	Gait Apraxia	3.4%
593	Asthenopia	3.3%
594	Conjunctival Diseases	3.3%
595	Corneal Diseases	3.3%
596	Eyelid Diseases	3.3%
597	Lacrimal Apparatus Diseases	3.3%
598	Lens Diseases	3.3%
599	Ocular Hypertension	3.3%
600	Ocular Hypotension	3.3%
601	Retinal Diseases	3.3%
602	Scleral Diseases	3.3%
603	Vitreous Detachment	3.3%
604	Posterior Vitreous Detachment	3.3%
605	Uveal Neoplasms	3.3%
606	Eyelid Neoplasms	3.3%
607	Retinal Hemorrhage	3.3%
608	Truncus Arteriosus, Persistent	3.3%
609	Goldenhar Syndrome	3.3%
610	Neurofibrosarcoma	3.2%
611	Arteriovenous fistula	3.1%
612	Vascular Headaches	3.1%
613	Esotropia	3.1%
614	Exotropia	3.1%
615	Hypoxia-Ischemia, Brain	3.1%
616	Tardive Dyskinesia	3.1%
617	Persistent Vegetative State	3.1%
618	Akinetic Mutism	3.1%
619	Anoxic Encephalopathy	3.1%
620	Arachnoiditis	3.1%
621	Basal Ganglia Diseases	3.1%
622	Brain Damage, Chronic	3.1%
623	Cerebellar Diseases	3.1%
624	Encephalitis	3.1%
625	Encephalomalacia	3.1%
626	Epilepsy	3.1%
627	Hydrocephalus	3.1%
628	Congenital Hydrocephalus	3.1%
629	Hypothalamic Diseases	3.1%
630	Aseptic Meningitis	3.1%
631	Syringomyelia	3.1%
632	Thalamic Diseases	3.1%
633	Intracranial Hypertension	3.1%
634	Aura	3.1%
635	Leukoencephalopathy	3.1%
636	Essential Tremor	3.1%
637	Neuroaxonal Dystrophies	3.1%
638	Familial Tremor	3.1%
639	Headache Disorders	3.1%
640	Intracranial Hypotension	3.1%
641	Brain Edema	3.1%
642	Brain Hypoxia	3.1%
643	Aqueductal Stenosis	3.1%
644	Pneumorrhachis	3.1%
645	Writer's Cramp	3.1%
646	Talipes	3.1%
647	Basal Ganglia Hemorrhage	3.1%
648	Corneal Perforation	3.1%
649	Eye Infection	3%
650	Eye Manifestations	3%
651	Eye Neoplasms	3%
652	Subarachnoid Hemorrhage, Traumatic	3%
653	Carotid Artery, Internal, Dissection	3%
654	Hyaline Membrane Disease	3%
655	Xerophthalmia	3%
656	Low Tension Glaucoma	3%
657	Iridocorneal endothelial syndrome	3%
658	Giant Cell Arteritis	2.9%
659	Temporal Arteritis	2.9%
660	Myoclonic Epilepsy	2.9%
661	Epilepsy, Temporal Lobe	2.9%
662	Epilepsy, Rolandic	2.9%
663	Benign Rolandic Epilepsy	2.9%
664	Subacute Sclerosing Panencephalitis	2.9%
665	Meningitis, Cryptococcal	2.9%
666	Meningitis, Listeria	2.9%
667	Meningitis, Haemophilus	2.9%
668	Meningitis, Pneumococcal	2.9%
669	Hemianopsia	2.8%
670	Brain Diseases, Metabolic	2.8%
671	Cerebrovascular Disorders	2.8%
672	Cerebrovascular Insufficiency	2.8%
673	Arsenic Poisoning	2.8%
674	Dementia	2.8%
675	Central Nervous System Fungal Infections	2.8%
676	Conus Medullaris Syndrome	2.8%
677	Spinal Cord Vascular Diseases	2.8%
678	Facial Injuries	2.8%
679	Facial Neuralgia	2.8%
680	Sleep Talking	2.8%
681	Manganese Poisoning	2.8%
682	Sleep Disorders, Intrinsic	2.8%
683	Orthostatic intolerance	2.8%
684	Auditory Perceptual Disorders	2.8%
685	Anosmia	2.8%
686	Ataxia	2.8%
687	Athetosis	2.8%
688	Catalepsy	2.8%
689	Dystonia	2.8%
690	Hemiplegia	2.8%
691	Locked-In Syndrome	2.8%
692	Meningeal Neoplasms	2.8%
693	Muscle Hypertonia	2.8%
694	Muscle hypotonia	2.8%
695	Myoclonus	2.8%
696	Myotonia	2.8%
697	Paraplegia	2.8%
698	Pseudobulbar Palsy	2.8%
699	Quadriplegia	2.8%
700	Spasm	2.8%
701	Spastic Paraplegia	2.8%
702	Status Epilepticus	2.8%
703	Taste Disorders	2.8%
704	Tremor	2.8%
705	Monoplegia	2.8%
706	Polymyositis	2.8%
707	Hypokinesia	2.8%
708	Paraparesis	2.8%
709	Bradykinesia	2.8%
710	Waxy flexibility	2.8%
711	Action Tremor	2.8%
712	Resting Tremor	2.8%
713	Dysosmia	2.8%
714	Quadriparesis	2.8%
715	Mercury Poisoning, Nervous System	2.8%
716	Olfaction Disorders	2.8%
717	Myokymia	2.8%
718	Lead Poisoning, Nervous System	2.8%
719	Vestibular Neuronitis	2.8%
720	Somatosensory Disorders	2.8%
721	Hyperkinesia	2.8%
722	Intention tremor	2.8%
723	Eye Hemorrhage	2.8%
724	Congenital clubfoot	2.8%
725	Vertical Talus	2.8%
726	Corneal Ulcer	2.7%
727	Choroid Hemorrhage	2.7%
728	Keratoconjunctivitis Sicca	2.7%
729	Diffuse Axonal Injury	2.7%
730	Brain Stem Neoplasms	2.7%
731	Putaminal Hemorrhage	2.7%
732	Central Nervous System Bacterial Infections	2.6%
733	Facial Hemiatrophy	2.6%
734	Melkersson-Rosenthal Syndrome	2.6%
735	Trachoma	2.6%
736	Confusion	2.6%
737	Facial paralysis	2.6%
738	Lethargy	2.6%
739	Memory Disorders	2.6%
740	Muscle Cramp	2.6%
741	Perceptual Disorders	2.6%
742	Psychomotor Disorders	2.6%
743	Anhedonia	2.6%
744	Disorientation	2.6%
745	Facial Paresis	2.6%
746	Memory Loss	2.6%
747	Hemisensory Neglect	2.6%
748	Dysacusis	2.6%
749	Sleep Bruxism	2.6%
750	Muscular Atrophy	2.6%
751	Respiratory Paralysis	2.6%
752	Pyomyositis	2.6%
753	Tetany	2.6%
754	Infarction, Middle Cerebral Artery	2.6%
755	Infarction, Anterior Cerebral Artery	2.6%
756	Infarction, Posterior Cerebral Artery	2.6%
757	Hordeolum	2.5%
758	Pituitary Apoplexy	2.5%
759	Chorioretinitis	2.5%
760	Juvenile Myoclonic Epilepsy	2.5%
761	Myoclonic Epilepsies, Progressive	2.5%
762	Brain Contusion	2.5%
763	Brain Infarction	2.5%
764	Amaurosis Fugax	2.4%
765	Blindness, Cortical	2.4%
766	Consciousness Disorders	2.4%
767	Mental Retardation	2.4%
768	Muscle Weakness	2.4%
769	Depressed Level of Consciousness	2.4%
770	Mental deficiency	2.4%
771	Intellectual Disability	2.4%
772	Bell Palsy	2.4%
773	Catatonia	2.4%
774	Herpes Zoster Oticus	2.4%
775	Aphonia	2.4%
776	Sleep Deprivation	2.4%
777	Dysphonia	2.4%
778	Keratoconjunctivitis	2.4%
779	West Nile Fever	2.4%
780	Hematoma, Subdural	2.3%
781	Hematoma, Epidural, Cranial	2.3%
782	Alexia	2.3%
783	Dyslexia	2.3%
784	Choroid Plexus Papilloma	2.3%
785	Polyneuropathy	2.3%
786	Pars Planitis	2.2%
787	Moyamoya Disease	2.1%
788	Cerebral Palsy	2.1%
789	Epilepsies, Partial	2.1%
790	Epilepsy, Generalized	2.1%
791	Pseudotumor Cerebri	2.1%
792	Hypertensive Encephalopathy	2.1%
793	Simple Partial Seizures	2.1%
794	Epilepsy, Reflex	2.1%
795	Postural Orthostatic Tachycardia Syndrome	2.1%
796	Headache Disorders, Primary	2.1%
797	Headache Disorders, Secondary	2.1%
798	Medication overuse headache	2.1%
799	Cerebral Infarction	2.1%
800	Brain Stem Infarctions	2.1%
801	Hoarseness	2.1%
802	Alcohol Withdrawal Delirium	2.1%
803	Acanthamoeba Keratitis	2%
804	Keratitis, Herpetic	2%
805	Cytomegalovirus Retinitis	2%
806	Bacterial conjunctivitis	2%
807	Angioid Streaks	2%
808	Anisometropia	2%
809	Aphakia	2%
810	Astigmatism	2%
811	Blepharitis	2%
812	Blepharoptosis	2%
813	Blepharospasm	2%
814	Choroid Diseases	2%
815	Conjunctivitis	2%
816	Corneal edema	2%
817	Corneal Opacity	2%
818	Dacryocystitis	2%
819	Dry Eye Syndromes	2%
820	Ectropion	2%
821	Enophthalmos	2%
822	Entropion	2%
823	Episcleritis	2%
824	Exophthalmos	2%
825	Glaucoma	2%
826	Iris Diseases	2%
827	Keratitis	2%
828	Keratoconus	2%
829	Lacrimal Duct Obstruction	2%
830	Lens dislocation	2%
831	Lens Subluxation	2%
832	Mydriasis	2%
833	Myopia	2%
834	Presbyopia	2%
835	Pterygium	2%
836	Retinal Detachment	2%
837	Retinitis	2%
838	Scleritis	2%
839	Uveitis	2%
840	Corneal Neovascularization	2%
841	Orbital Pseudotumor	2%
842	Cataract	2%
843	Pinguecula	2%
844	Trichiasis	2%
845	Pituitary Diseases	2%
846	Carotid Artery Diseases	1.9%
847	Brain Ischemia	1.9%
848	Hypotension, Orthostatic	1.9%
849	Sleep Apnea Syndromes	1.9%
850	Cerebrovascular accident	1.9%
851	Kluver-Bucy Syndrome	1.9%
852	Vasospasm, Intracranial	1.9%
853	Spinal Cord Ischemia	1.9%
854	Intracranial Arterial Diseases	1.9%
855	Post-Exercise Hypotension	1.9%
856	Choroiditis	1.9%
857	Iridocyclitis	1.9%
858	Iritis	1.9%
859	Disorders of Excessive Somnolence	1.9%
860	Sleep Initiation and Maintenance Disorders	1.9%
861	Night Terrors	1.9%
862	Somnambulism	1.9%
863	Trigeminal Nerve Disorder	1.9%
864	Transient Insomnia	1.9%
865	Sleep Paralysis	1.9%
866	Chronic Insomnia	1.9%
867	REM Sleep Behavior Disorder	1.9%
868	Hypersomnia	1.9%
869	Lateral Medullary Syndrome	1.9%
870	Dysgeusia	1.9%
871	Formication	1.9%
872	Hyperalgesia	1.9%
873	Hyperesthesia	1.9%
874	Hypesthesia	1.9%
875	Language Disorders	1.9%
876	Numbness	1.9%
877	Paresthesia	1.9%
878	Paraparesis, Spastic	1.9%
879	Trismus	1.9%
880	Epilepsia Partialis Continua	1.9%
881	Hypogeusia	1.9%
882	Meningeal Carcinomatosis	1.9%
883	Brown-Sequard Syndrome	1.9%
884	Lockjaw	1.9%
885	Allodynia	1.9%
886	Lead Poisoning, Nervous System, Childhood	1.9%
887	Lead Poisoning, Nervous System, Adult	1.9%
888	Ageusia	1.9%
889	Tuberculosis, Central Nervous System	1.9%
890	Hematoma, Subdural, Intracranial	1.9%
891	Hematoma, Subdural, Chronic	1.9%
892	Hematoma, Subdural, Acute	1.9%
893	Panophthalmitis	1.8%
894	Endophthalmitis	1.8%
895	Pemphigoid, Benign Mucous Membrane	1.8%
896	Retinal Artery Occlusion	1.8%
897	Orbital Cellulitis	1.8%
898	Retinal Vasculitis	1.8%
899	Hypertensive Retinopathy	1.8%
900	Retrobulbar Hemorrhage	1.8%
901	Corneal Endothelial Cell Loss	1.8%
902	Hyphema	1.8%
903	Retinal Neovascularization	1.8%
904	Vitreous Hemorrhage	1.8%
905	Dermatomyositis	1.8%
906	Muscle Rigidity	1.8%
907	Muscle Spasticity	1.8%
908	Cogwheel Rigidity	1.8%
909	Hemifacial Spasm	1.8%
910	Nuchal Rigidity	1.8%
911	Reye Syndrome	1.8%
912	Neuroaspergillosis	1.8%
913	Intracranial Embolism and Thrombosis	1.8%
914	Hepatic Encephalopathy	1.8%
915	Agnosia	1.8%
916	Apraxias	1.8%
917	Hallucinations	1.8%
918	Hyperacusis	1.8%
919	Tinnitus	1.8%
920	Visual Agnosia	1.8%
921	Anosognosia	1.8%
922	Wernicke-Korsakoff Syndrome	1.8%
923	Phonophobia	1.8%
924	Hearing Loss	1.8%
925	Sarcopenia	1.8%
926	Pseudorabies	1.7%
927	Waterhouse-Friderichsen Syndrome	1.7%
928	Retinal Vein Occlusion	1.6%
929	Diabetic Retinopathy	1.6%
930	Eye pain	1.6%
931	Amnesia	1.6%
932	Delirium	1.6%
933	Dissociative Amnesia	1.6%
934	Global Amnesia	1.6%
935	Meningioma	1.6%
936	Post-Traumatic Headache	1.6%
937	Tension Headache	1.6%
938	Epilepsy, Complex Partial	1.6%
939	Migraine Disorders	1.6%
940	Abdominal Migraine	1.6%
941	Status Migrainosus	1.6%
942	Cervicogenic Headache	1.6%
943	Neurosyphilis	1.6%
944	Wernicke Encephalopathy	1.5%
945	AIDS Dementia Complex	1.5%
946	Phantom pain	1.5%
947	Phantom Limb Pain	1.5%
948	Lyme Neuroborreliosis	1.5%
949	Empty Sella Syndrome	1.5%
950	Hyperpituitarism	1.5%
951	Hypopituitarism	1.5%
952	Hypophysitis	1.5%
953	Cerebral Arterial Diseases	1.5%
954	Vertebrobasilar Insufficiency	1.5%
955	Anterior Spinal Artery Syndrome	1.5%
956	Basilar Artery Stenosis	1.5%
957	Vertebral Artery Stenosis	1.5%
958	Sleep Apnea, Obstructive	1.5%
959	Sleep Apnea, Central	1.5%
960	Intracranial Hemorrhage, Hypertensive	1.5%
961	Transient Cerebral Ischemia	1.5%
962	Narcolepsy	1.5%
963	Trigeminal Neuralgia	1.5%
964	Kleine-Levin Syndrome	1.5%
965	Agraphia	1.5%
966	Anomia	1.5%
967	Cluttering	1.5%
968	Language Development Disorders	1.5%
969	Speech Disorders	1.5%
970	Syncope	1.5%
971	Stupor	1.5%
972	Dysgraphia	1.5%
973	Presyncope	1.5%
974	Dyslalia	1.5%
975	Cluster Headache	1.4%
976	Migraine with Aura	1.4%
977	Familial Hemiplegic Migraine	1.4%
978	Chronic Paroxysmal Hemicrania	1.4%
979	SUNCT Syndrome	1.4%
980	Paroxysmal Hemicrania	1.4%
981	Eye Burns	1.4%
982	Malaria, Cerebral	1.4%
983	Carotid Stenosis	1.4%
984	Intracranial Aneurysm	1.4%
985	Neurocysticercosis	1.4%
986	Dyscalculia	1.4%
987	Intracranial Arteriosclerosis	1.4%
988	Cerebral Atherosclerosis	1.4%
989	Subarachnoid Hemorrhage	1.4%
990	Cerebral Arteriosclerosis	1.4%
991	Cerebral Hemorrhage	1.4%
992	Cerebral Thrombosis	1.3%
993	Intracranial Embolism	1.3%
994	Intracranial Thrombosis	1.3%
995	Deafness	1.3%
996	Hearing Loss, Sudden	1.3%
997	Gerstmann Syndrome	1.3%
998	Hearing Loss, Bilateral	1.3%
999	Hearing Loss, High-Frequency	1.3%
1000	Hearing Loss, Mixed Conductive-Sensorineural	1.3%
1001	Prosopagnosia	1.3%
1002	Apraxia, Ideomotor	1.3%
1003	Charles Bonnet Syndrome	1.3%
1004	Hearing Loss, Unilateral	1.3%
1005	Complete Hearing Loss	1.3%
1006	Alien Hand Syndrome	1.3%
1007	Deaf Mutism	1.3%
1008	Angle Closure Glaucoma	1.3%
1009	Glaucoma, Open-Angle	1.3%
1010	Macular degeneration	1.3%
1011	Panuveitis	1.3%
1012	Retinal Drusen	1.3%
1013	Retinal Necrosis Syndrome, Acute	1.3%
1014	Retinoschisis	1.3%
1015	Exfoliation Syndrome	1.3%
1016	Hyperprolactinemia	1.3%
1017	Subclavian Steal Syndrome	1.3%
1018	Pick Disease of the Brain	1.3%
1019	Cataplexy	1.3%
1020	Aphasia	1.2%
1021	Articulation Disorders	1.2%
1022	Echolalia	1.2%
1023	Stuttering	1.2%
1024	Dysphasia	1.2%
1025	Retrograde amnesia	1.2%
1026	Amnesia, Anterograde	1.2%
1027	Carotid Artery Thrombosis	1.2%
1028	Choroidal Neovascularization	1.2%
1029	Mutism	1.2%
1030	Selective Mutism	1.2%
1031	Acromegaly	1.2%
1032	Cerebral Amyloid Angiopathy	1.1%
1033	Sinus Thrombosis, Intracranial	1.1%
1034	Dysarthria	1.1%
1035	Herpes Zoster Ophthalmicus	1.1%
1036	Alexia, Pure	1%
1037	Cavernous Sinus Thrombosis	1%
1038	Sagittal Sinus Thrombosis	1%
1039	Graves Disease	1%
1040	Prolactinoma	1%
1041	Growth Hormone-Secreting Pituitary Adenoma	1%
1042	Anterior uveitis	1%
1043	Uveitis, Posterior	1%
1044	Nelson Syndrome	1%
1045	Sicca Syndrome	0.9%
1046	Sjogren's Syndrome	0.9%

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