MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lysosomal Storage Diseases

(UMLS:C0085078)

Definition:: Inborn errors of metabolism characterized by defects in specific lysosomal hydrolases and resulting in intracellular accumulation of unmetabolized substrates.
UMLS ID:: C0085078
MeSH ID:: D016464

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.595

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.648.595

Synonym(s)

Lysosomal Storage Diseases

Disorder of Lysosomal Enzymes

Disorder of lysosomal enzyme

Disorder of lysosomal enzyme, NOS

Lysosomal Storage Disease

Lysosomal Storage Disorder

Lysosomal enzyme defect

Lysosomal enzyme disorder

Lysosomal storage disease

10.

Lysosomal storage diseases

11.

PHOSPHOLIPIDOSIS

12.

defect; lysosomal enzyme

13.

inborn lysosomal enzyme disorder

14.

lysosomal enzyme; defect

15.

lysosomal storage disease

16.

lysosomal storage diseases

17.

lysosomal storage disorder

18.

lysosomal storage disorders

Associated Drug(s)

	Name	Reference(s)	Data Source
1	3,3'-diethylthiacarbocyanine iodide	28551711	CTD
2	Amlodipine	28551711	CTD
3	Aprindine	28551711	CTD
4	Azithromycin	28551711	CTD
5	Benztropine	28551711	CTD
6	Butaclamol	28551711	CTD
7	Cabergoline	28551711	CTD
8	Chlorprothixene	28551711	CTD
9	Clemastine	28551711	CTD
10	Clopenthixol	28551711	CTD
11	Clotrimazole	28551711	CTD
12	Colchicine	28551711	CTD
13	Dibucaine	28551711	CTD
14	Domperidone	28551711	CTD
15	Doxorubicin	28551711	CTD
16	Duloxetine Hydrochloride	28551711	CTD
17	Dutasteride	28551711	CTD
18	Erlotinib Hydrochloride	28551711	CTD
19	Fendiline	28551711	CTD
20	Flupenthixol	28551711	CTD
21	Flurazepam	28551711	CTD
22	GR 103691	28551711	CTD
23	Hymecromone	24295952	CTD
24	Imatinib Mesylate	28551711	CTD
25	Lidoflazine	28551711	CTD
26	Lofepramine	28551711	CTD
27	Mebendazole	28551711	CTD
28	Mercaptopurine	28551711	CTD
29	Methiothepin	28551711	CTD
30	Mibefradil	28551711	CTD
31	Nonachlazine	28551711	CTD
32	Orlistat	28551711	CTD
33	Perphenazine	28551711	CTD
34	Pizotyline	28551711	CTD
35	Proadifen	28551711	CTD
36	Probucol	28551711	CTD
37	Promazine	28551711	CTD
38	Quinacrine	28551711	CTD
39	Reserpine	28551711	CTD
40	Salmeterol Xinafoate	28551711	CTD
41	Sertraline	28551711	CTD
42	Tamoxifen	28551711	CTD
43	Thioguanine	28551711	CTD
44	Tilorone	28551711	CTD
45	Toremifene	28551711	CTD
46	Triflupromazine	28551711	CTD
47	Vincristine	28551711	CTD
48	aprofen	28551711	CTD
49	azelastine	28551711	CTD
50	bifemelane	28551711	CTD
51	bromperidol	28551711	CTD
52	bucindolol	28551711	CTD
53	cepharanthine	28551711	CTD
54	clothiapine	28551711	CTD
55	darifenacin	28551711	CTD
56	decominol	28551711	CTD
57	desloratadine	28551711	CTD
58	dibenzheptropine	28551711	CTD
59	dimethisoquin	28551711	CTD
60	ebastine	28551711	CTD
61	eletriptan	28551711	CTD
62	fenoverine	28551711	CTD
63	halofantrine	28551711	CTD
64	ifenprodil	28551711	CTD
65	lenperone	28551711	CTD
66	levomepromazine maleate	28551711	CTD
67	lomerizine	28551711	CTD
68	mepazine	28551711	CTD
69	methdilazine	28551711	CTD
70	methixene	28551711	CTD
71	nefazodone	28551711	CTD
72	niguldipine	28551711	CTD
73	octoclothepine	28551711	CTD
74	oxeladin	28551711	CTD
75	oxyphencyclimine	28551711	CTD
76	perhexiline maleate	28551711	CTD
77	periciazine	28551711	CTD
78	perospirone	28551711	CTD
79	pyrathiazine	28551711	CTD
80	pyrvinium	28551711	CTD
81	rescinnamine	28551711	CTD
82	rimcazole	28551711	CTD
83	terconazole	28551711	CTD
84	tiamulin	28551711	CTD
85	triciribine	28551711	CTD
86	trimeprazine tartrate	28551711	CTD
87	valnemulin	28551711	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Amino Acid Metabolism, Inborn Errors	46.7%
2	Carbohydrate Metabolism, Inborn Errors	46.7%
3	Metal Metabolism, Inborn Errors	46.7%
4	Progeria	46.7%
5	Peroxisomal Disorders	46.7%
6	Smith-Lemli-Opitz Syndrome	39.6%
7	Galactosemias	37.7%
8	Urea Cycle Disorders, Inborn	37.7%
9	Tyrosinemias	37.7%
10	Brain Diseases, Metabolic, Inborn	37.6%
11	Leigh Disease	35.3%
12	Alkaptonuria	34.4%
13	Glycogen Storage Disease	34.4%
14	Hypophosphatasia	34.4%
15	Propionic acidemia	34.4%
16	Dihydropyrimidine Dehydrogenase Deficiency	34.4%
17	Hyperphosphaturia	33.5%
18	Hypolipoproteinemias	33.3%
19	Cytochrome-c Oxidase Deficiency	33.3%
20	Hyperlipidemia, Familial Combined	32.2%
21	Carbamoyl-Phosphate Synthase I Deficiency Disease	32.1%
22	Hyperlipoproteinemia Type III	31.7%
23	Homocystinuria	31.2%
24	Pseudohypoparathyroidism	31.1%
25	Hyperhomocysteinemia	30.6%
26	Menkes Kinky Hair Syndrome	30%
27	Hyperlipoproteinemia Type IV	29.9%
28	Hyperlipoproteinemia Type V	29.9%
29	Lactose Intolerance	29.5%
30	Glycogen Storage Disease Type I	28.5%
31	Glycogen Storage Disease Type V	28.5%
32	Adrenoleukodystrophy	27.5%
33	Hypoalphalipoproteinemias	27.5%
34	Hepatolenticular Degeneration	26.5%
35	Zellweger Syndrome	26.5%
36	Refsum Disease	26.2%
37	Neuronal Ceroid-Lipofuscinoses	26.2%
38	Werner Syndrome	25.4%
39	Amyloid Neuropathies, Familial	25%
40	Glycogen storage disease type II	24.8%
41	Albinism	24.4%
42	Renal tubular acidosis	23.7%
43	Familial Periodic Paralysis	23.3%
44	Familial Hypophosphatemic Rickets	23.3%
45	Renal Aminoacidurias	22.8%
46	Fanconi Syndrome	22.8%
47	Pseudohypoaldosteronism	22.8%
48	Liddle Syndrome	22.8%
49	Gaucher Disease	22.4%
50	Ichthyosis, X-Linked	21.8%
51	Antley-Bixler Syndrome Phenotype	21%
52	Wasting Syndrome	20.7%
53	Acid-Base Imbalance	20.5%
54	Calcium Metabolism Disorders	20.5%
55	Iron Metabolism Disorders	20.5%
56	Phosphorus Metabolism Disorders	20.5%
57	Water-Electrolyte Imbalance	20.5%
58	Lipid Metabolism Disorders	20.5%
59	Mitochondrial Diseases	20.5%
60	Glucose Metabolism Disorders	20.5%
61	Fabry Disease	20.4%
62	Tay-Sachs Disease	20.2%
63	Gout	20%
64	Hypercalcemia	20%
65	Hypocalcemia	20%
66	Milk-Alkali Syndrome	20%
67	Niemann-Pick Disease, Type C	19.2%
68	Hypokalemic periodic paralysis	19%
69	Cystinuria	18.8%
70	Sjogren-Larsson Syndrome	18.7%
71	Glycosuria, Renal	18.3%
72	Canavan Disease	17.7%
73	Alexander Disease	17.7%
74	MELAS Syndrome	17.2%
75	Mucopolysaccharidosis II	17.1%
76	Cockayne Syndrome	16.6%
77	Arthritis, Gouty	16.3%
78	Mucopolysaccharidosis III	16.1%
79	Neoplastic Syndromes, Hereditary	16.1%
80	Lipodystrophy	16%
81	Osteopenia	15.5%
82	Brain Diseases, Metabolic	15.3%
83	Multiple Epiphyseal Dysplasia	15.3%
84	Osteochondrodysplasias	15.3%
85	Pelger-Huet Anomaly	15.3%
86	Myasthenic Syndromes, Congenital	15.3%
87	CHARGE Syndrome	14.9%
88	Rickets	14.4%
89	Cystic Fibrosis	14%
90	Aicardi's syndrome	13.9%
91	Fragile X Syndrome	13.9%
92	Porphyrias, Hepatic	13.5%
93	Congenital Hyperinsulinism	13.5%
94	Acidosis	13.3%
95	Alkalosis	13.3%
96	Amyloidosis	13.3%
97	Beckwith-Wiedemann Syndrome	13.3%
98	Bloom Syndrome	13.3%
99	Calcinosis	13.3%
100	Hyperglycemia	13.3%
101	Hyperinsulinism	13.3%
102	Hyperkalemia	13.3%
103	Hypernatremia	13.3%
104	Hypoglycemia	13.3%
105	Hypokalemia	13.3%
106	Hyponatremia	13.3%
107	Familial Mediterranean Fever	13.3%
108	Xanthomatosis	13.3%
109	Hypophosphatemia	13.3%
110	Metabolic acidosis	13.3%
111	Dyslipidemias	13.3%
112	Iron Overload	13.3%
113	Xanthoma	13.3%
114	Wolf-Hirschhorn Syndrome	13.3%
115	Anemia, Sickle Cell	13.2%
116	Thalassemia	13.2%
117	Muscular Dystrophy, Duchenne	13.2%
118	Fanconi Anemia	13.1%
119	Dwarfism	12.7%
120	Nail-Patella Syndrome	12.5%
121	Muscular Dystrophy	12.1%
122	Osteogenesis Imperfecta	12.1%
123	Deformity	11.9%
124	Nutrition Disorders	11.9%
125	Rett Syndrome	11.7%
126	Smith-Magenis syndrome	11.2%
127	Ataxia Telangiectasia	11.2%
128	Cri-du-Chat Syndrome	11%
129	Down Syndrome	11%
130	Trisomy 21	11%
131	Optic Atrophy, Hereditary, Leber	10.9%
132	Osteomalacia	10.9%
133	Prader-Willi Syndrome	10.8%
134	Diabetic Ketoacidosis	10.8%
135	Alstrom Syndrome	10.7%
136	Diabetes Mellitus	10.5%
137	Nesidioblastosis	10.4%
138	Autoimmune Lymphoproliferative Syndrome	10.2%
139	Dehydration	10.2%
140	Lipomatosis	10.2%
141	Water Intoxication	10.2%
142	Achlorhydria	10%
143	Osteoporosis	10%
144	Bone Demineralization, Pathologic	10%
145	Post-Traumatic Osteoporosis	10%
146	Angioedemas, Hereditary	9.9%
147	Celiac Disease	9.9%
148	Sprue, Tropical	9.9%
149	Steatorrhea	9.9%
150	Sprue	9.9%
151	Wiskott-Aldrich Syndrome	9.9%
152	Acidosis, Lactic	9.9%
153	Calciphylaxis	9.9%
154	Hemosiderosis	9.9%
155	Ketosis	9.9%
156	Ketonuria	9.9%
157	Ketoacidosis	9.9%
158	Ketonemia	9.9%
159	Vascular calcification	9.9%
160	Mitochondrial Encephalomyopathies	9.9%
161	Variegate Porphyria	9.8%
162	Acute intermittent porphyria	9.8%
163	Porphyria Cutanea Tarda	9.8%
164	Friedreich Ataxia	9.8%
165	Sickle Cell Trait	9.7%
166	Holoprosencephaly	9.6%
167	Ectodermal Dysplasia	9.5%
168	Aplasia Cutis Congenita	9.5%
169	Xeroderma Pigmentosum	9.4%
170	Marfan Syndrome	9.4%
171	Kartagener Syndrome	9.3%
172	Fetal Diseases	8.9%
173	Primary Ciliary Dyskinesia	8.9%
174	Myotonic Dystrophy	8.8%
175	Polycystic Kidney Diseases	8.8%
176	Williams Syndrome	8.8%
177	Kallmann Syndrome	8.4%
178	Rubinstein-Taybi Syndrome	8.4%
179	Hypercholesterolemia	8.2%
180	Hyperlipoproteinemias	8.2%
181	Hypertriglyceridemia	8.2%
182	Tuberous Sclerosis	8.2%
183	Cutis Laxa	8.1%
184	Mitochondrial Myopathies	8.1%
185	Retinitis Pigmentosa	8.1%
186	Myelinolysis, Central Pontine	8.1%
187	Pigmentary retinopathy	8.1%
188	Porokeratosis	8%
189	Keratoderma, Palmoplantar	8%
190	Glycosuria	7.9%
191	Chronic granulomatous disease	7.9%
192	Reye Syndrome	7.9%
193	Hepatic Encephalopathy	7.9%
194	Welander Distal Myopathy	7.9%
195	Retinal Dysplasia	7.8%
196	Aniridia	7.8%
197	Epidermolysis Bullosa	7.6%
198	HIV Wasting Syndrome	7.5%
199	Acute Chest Syndrome	7.5%
200	Acidosis, Respiratory	7.4%
201	Adiposis Dolorosa	7.4%
202	Alkalosis, Respiratory	7.4%
203	Insulin Resistance	7.4%
204	Osteoporosis, Postmenopausal	7.4%
205	HIV-Associated Lipodystrophy Syndrome	7.3%
206	Renal Osteodystrophy	7.3%
207	Renal rickets	7.3%
208	Abdominal Cramps	6.8%
209	Abnormalities, Drug-Induced	6.8%
210	Amniotic Band Syndrome	6.8%
211	Asphyxia Neonatorum	6.8%
212	Child Nutrition Disorders	6.8%
213	Duane Retraction Syndrome	6.8%
214	Hypervitaminosis A	6.8%
215	Infant Nutrition Disorders	6.8%
216	Infant, Premature, Diseases	6.8%
217	Situs Inversus	6.8%
218	Malnutrition	6.8%
219	Infantile Colic	6.8%
220	Kernicterus	6.7%
221	Peutz-Jeghers Syndrome	6.6%
222	Wernicke Encephalopathy	6.6%
223	Myotonia Congenita	6.6%
224	Thrombasthenia	6.6%
225	Antithrombin III Deficiency	6.6%
226	Necrobiosis Lipoidica Diabeticorum	6.6%
227	Protein C Deficiency	6.6%
228	Afibrinogenemia	6.6%
229	Dystonia Musculorum Deformans	6.6%
230	Factor VII Deficiency	6.6%
231	Factor X Deficiency	6.6%
232	Factor XII Deficiency	6.6%
233	Hemophilia A	6.6%
234	Activated Protein C Resistance	6.6%
235	Factor II deficiency	6.6%
236	Factor VIII Deficiency	6.6%
237	Factor V deficiency	6.6%
238	Factor XI Deficiency	6.6%
239	Hypoprothrombinemias	6.6%
240	Lafora Disease	6.5%
241	Unverricht-Lundborg Syndrome	6.5%
242	Anemia, Diamond-Blackfan	6.5%
243	Polycystic Kidney, Autosomal Dominant	6.5%
244	Classical Lissencephalies and Subcortical Band Heterotopias	6.3%
245	Gestational Diabetes	6.1%
246	Latent Autoimmune Diabetes in Adults	6.1%
247	Diabetes Mellitus, Experimental	6%
248	Pseudoxanthoma Elasticum	5.9%
249	Nephrocalcinosis	5.9%
250	Tetany	5.9%
251	Meconium Aspiration Syndrome	5.9%
252	Multiple Endocrine Neoplasia	5.9%
253	Papillon-Lefevre Disease	5.9%
254	Hyperkeratosis, Epidermolytic	5.9%
255	Cerebral Amyloid Angiopathy	5.8%
256	Congenital Hypothyroidism	5.7%
257	Dermatitis, Atopic	5.7%
258	Xeroderma	5.6%
259	Mobius Syndrome	5.6%
260	Charcot-Marie-Tooth Disease	5.6%
261	Eye Abnormalities	5.4%
262	Cardiovascular Abnormalities	5.4%
263	Kearns-Sayre syndrome	5.3%
264	Skin Abnormalities	5.2%
265	Lymphatic Abnormalities	5.2%
266	Congenital Microtia	5.2%
267	Anemia, Neonatal	5.1%
268	Persistent Fetal Circulation Syndrome	5.1%
269	Congenital diaphragmatic hernia	5%
270	Umbilical hernia	5%
271	Behcet Syndrome	5%
272	Primary amyloidosis	5%
273	Basal Cell Nevus Syndrome	4.8%
274	Anencephaly	4.6%
275	Klinefelter Syndrome	4.5%
276	Deficiency Diseases	4.4%
277	Prune Belly Syndrome	4.4%
278	Starvation	4.4%
279	Twins, Conjoined	4.4%
280	Refeeding Syndrome	4.4%
281	Waardenburg Syndrome	4.4%
282	Huntington Disease	4.4%
283	Urogenital Abnormalities	4.3%
284	Amyotrophic Lateral Sclerosis	4.3%
285	Multiple Endocrine Neoplasia Type 1	4.2%
286	Hydrops Fetalis	4.2%
287	Neonatal Abstinence Syndrome	4.2%
288	Fetal Growth Retardation	4.1%
289	Frontotemporal dementia	4.1%
290	Fetal Hypoxia	4%
291	Congenital nystagmus	4%
292	Fetal Alcohol Spectrum Disorders	4%
293	Toxoplasmosis, Congenital	4%
294	Syphilis, Congenital	4%
295	Nephroblastoma	3.9%
296	Maxillofacial Abnormalities	3.9%
297	Dural Arteriovenous Fistula	3.9%
298	Turner Syndrome	3.9%
299	Dextrocardia	3.9%
300	CREST Syndrome	3.7%
301	Adenomatous Polyposis Coli	3.5%
302	Anophthalmos	3.4%
303	Anus, Imperforate	3.4%
304	Hydranencephaly	3.4%
305	Microphthalmos	3.4%
306	Neural Tube Defects	3.4%
307	Paralysis, Obstetric	3.4%
308	Retinopathy of Prematurity	3.4%
309	Tethered Cord Syndrome	3.4%
310	Iniencephaly	3.4%
311	Craniorachischisis	3.4%
312	Limb Deformities, Congenital	3.4%
313	Exencephaly	3.4%
314	Septo-Optic Dysplasia	3.4%
315	Craniofacial Abnormalities	3.4%
316	Cortical Dysplasia	3.4%
317	Malformations of Cortical Development	3.4%
318	Anorectal Malformations	3.4%
319	Chorioamnionitis	3.4%
320	Bronchopulmonary Dysplasia	3.3%
321	Kwashiorkor	3.3%
322	Magnesium Deficiency	3.3%
323	Potassium Deficiency	3.3%
324	Protein Deficiency	3.3%
325	Avitaminosis	3.3%
326	Microcephaly	3%
327	Macrocephaly	3%
328	Scimitar Syndrome	3%
329	Abnormalities, Radiation-Induced	2.9%
330	Craniosynostosis	2.8%
331	Syndactyly	2.8%
332	Brachycephaly	2.8%
333	Blepharophimosis	2.7%
334	Laryngostenosis	2.7%
335	Mouth Abnormalities	2.7%
336	Respiratory Distress Syndrome, Newborn	2.7%
337	Ascorbic Acid Deficiency	2.7%
338	Vitamin A Deficiency	2.7%
339	Vitamin D Deficiency	2.7%
340	Vitamin E Deficiency	2.7%
341	Marasmus	2.7%
342	Esophageal Atresia	2.7%
343	Intestinal Atresia	2.7%
344	Horseshoe Kidney	2.7%
345	Pectus excavatum	2.7%
346	Porencephaly	2.7%
347	Klippel-Feil Syndrome	2.7%
348	Gastroschisis	2.7%
349	Synostosis	2.7%
350	Acrocephalosyndactylia	2.7%
351	Acrodermatitis	2.7%
352	Lymphangiectasis, Intestinal	2.7%
353	Gianotti-Crosti Syndrome	2.7%
354	Denys-Drash Syndrome	2.6%
355	Noonan Syndrome	2.5%
356	Amelia	2.5%
357	Arachnodactyly	2.5%
358	Ectopia Cordis	2.5%
359	Ectromelia	2.5%
360	Hemimelia	2.5%
361	Meningomyelocele	2.5%
362	Phocomelia	2.5%
363	Sirenomelia	2.5%
364	Spina Bifida	2.5%
365	Polydactyly	2.5%
366	Brachydactyly	2.5%
367	Plagiocephaly	2.5%
368	Lower Extremity Deformities, Congenital	2.5%
369	Upper Extremity Deformities, Congenital	2.5%
370	Single umbilical artery	2.5%
371	Ophthalmia Neonatorum	2.5%
372	Folic Acid Deficiency	2.5%
373	Pellagra	2.5%
374	Thiamine Deficiency	2.5%
375	Vitamin B 12 Deficiency	2.5%
376	Vitamin B 6 Deficiency	2.5%
377	Pyridoxine Deficiency	2.5%
378	Beriberi	2.3%
379	Poland Syndrome	2.3%
380	Cleft Palate	2.3%
381	Arthrogryposis	2.3%
382	Choanal Atresia	2.3%
383	Tracheobronchomegaly	2.3%
384	Laryngocele	2.3%
385	Jaw Abnormalities	2.3%
386	Choledochal Cyst	2.3%
387	Hermaphroditism	2.3%
388	Disorders of Sex Development	2.3%
389	Cryptorchidism	2.2%
390	Hypospadias	2.2%
391	Central Nervous System Cysts	2.2%
392	Dandy-Walker Syndrome	2.2%
393	Leukomalacia, Periventricular	2.2%
394	POEMS Syndrome	2.2%
395	Obesity	2.2%
396	Dermal Sinus	2%
397	Spina Bifida Cystica	2%
398	Spina Bifida Occulta	2%
399	Lissencephaly	2%
400	Polymicrogyria	2%
401	Pachygyria	2%
402	Schizencephaly	2%
403	Periventricular Nodular Heterotopia	2%
404	Aortic coarctation	2%
405	Cor Triatriatum	2%
406	Coronary Vessel Anomalies	2%
407	Dental Enamel Hypoplasia	2%
408	Patent ductus arteriosus	2%
409	Ebstein Anomaly	2%
410	Heart Septal Defects	2%
411	Hyaline Membrane Disease	2%
412	Hypodontia	2%
413	Macrostomia	2%
414	Meningocele	2%
415	Microstomia	2%
416	Tetralogy of Fallot	2%
417	Transposition of Great Vessels	2%
418	Hypoplastic Left Heart Syndrome	2%
419	May-Thurner Syndrome	2%
420	Encephalocele	2%
421	Craniofacial Dysostosis	2%
422	Wolff-Parkinson-White Syndrome	2%
423	Laryngomalacia	2%
424	Pectus carinatum	1.9%
425	Obesity, Abdominal	1.9%
426	Micrognathism	1.9%
427	Pierre Robin Syndrome	1.9%
428	Bladder Exstrophy	1.9%
429	Epispadias	1.9%
430	Multicystic Dysplastic Kidney	1.9%
431	Retrognathia	1.7%
432	Anemia, Pernicious	1.7%
433	Long QT Syndrome	1.7%
434	Platybasia	1.7%
435	Tricuspid Atresia	1.7%
436	Arrhythmogenic Right Ventricular Dysplasia	1.7%
437	Vitamin K Deficiency	1.7%
438	Gonadal Dysgenesis	1.6%
439	Bronchomalacia	1.6%
440	Adrenogenital Syndrome	1.6%
441	Tracheomalacia	1.6%
442	Ovotesticular Disorders of Sex Development	1.6%
443	Aortopulmonary Septal Defect	1.6%
444	Double Outlet Right Ventricle	1.6%
445	Endocardial Cushion Defects	1.6%
446	Myocardial bridging	1.6%
447	Aorticopulmonary Septal Defect	1.6%
448	Hyperandrogenism	1.6%
449	Pediatric Obesity	1.6%
450	Prognathism	1.6%
451	Scurvy	1.5%
452	Truncus Arteriosus, Persistent	1.5%
453	Goldenhar Syndrome	1.5%
454	Mandibulofacial Dysostosis	1.4%
455	Romano-Ward Syndrome	1.4%
456	Talipes	1.2%
457	Congenital clubfoot	1.1%
458	Vertical Talus	1.1%
459	Arteriovenous fistula	1%
460	Subacute Combined Degeneration	1%

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