MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Toxoplasmosis, Congenital

(UMLS:C0040560)

Definition:: Prenatal protozoal infection with TOXOPLASMA gondii which is associated with injury to the developing fetal nervous system. The severity of this condition is related to the stage of pregnancy during which the infection occurs; first trimester infections are associated with a greater degree of neurologic dysfunction. Clinical features include HYDROCEPHALUS; MICROCEPHALY; deafness; cerebral calcifications; SEIZURES; and psychomotor retardation. Signs of a systemic infection may also be present at birth, including fever, rash, and hepatosplenomegaly. (From Adams et al., Principles of Neurology, 6th ed, p735)
UMLS ID:: C0040560
MeSH ID:: D014125

Classification 1:

Name:

Parasitic Diseases
MeSH Tree Number(s):: C03.752.250.800.445

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.228.205.300.900

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.614.909

Synonym(s)

Toxoplasmosis, Congenital

Congenital Toxoplasmosis

Congenital toxoplasmosis

Toxoplasmosis;congenital

congenital toxoplasmosis

congenital; toxoplasmosis

toxoplasmosis congenital

toxoplasmosis; congenital

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Prednisolone		21319040	CTD
2	acetylspiramycin		21319040	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Toxoplasmosis, Cerebral	25.8%
2	Malaria, Cerebral	23.6%
3	Encephalomyelitis	20.9%
4	Abdominal Cramps	20.3%
5	Amniotic Band Syndrome	20.3%
6	Asphyxia Neonatorum	20.3%
7	Infant, Premature, Diseases	20.3%
8	Infantile Colic	20.3%
9	Meningoencephalitis	18.8%
10	Isosporiasis	17.4%
11	Epidural Abscess	16.7%
12	Myelitis	16.6%
13	Anemia, Neonatal	16.2%
14	Persistent Fetal Circulation Syndrome	16.2%
15	Umbilical hernia	16%
16	Cystic Fibrosis	15.8%
17	Mobius Syndrome	15.6%
18	Prion Diseases	14.8%
19	Xeroderma	14.4%
20	Congenital nystagmus	14.2%
21	Cryptosporidiosis	14.1%
22	Neonatal Abstinence Syndrome	13.8%
23	Meconium Aspiration Syndrome	13.6%
24	Syphilis, Congenital	13.2%
25	Leukomalacia, Periventricular	12.7%
26	Amebiasis	12.7%
27	Malaria	12.7%
28	Acanthamoeba Infection	12.7%
29	Trichomonas Infections	12.7%
30	Ciliophora Infections	12.7%
31	Balamuthia Infection	12.7%
32	Paralysis, Obstetric	12.1%
33	Retinopathy of Prematurity	12.1%
34	Brain Abscess	11.9%
35	Bronchopulmonary Dysplasia	11.9%
36	Subdural Effusion	11.9%
37	Central Nervous System Fungal Infections	11.8%
38	Congenital Hyperinsulinism	11.5%
39	Protozoan Infections, Animal	11.5%
40	Brain Diseases	11.4%
41	Meningitis	11.4%
42	Movement Disorders	11.4%
43	Pachymeningitis	11.4%
44	Spinal Cord Diseases	11.4%
45	Giardiasis	11.3%
46	Ichthyosis, X-Linked	10.9%
47	Smith-Magenis syndrome	10.8%
48	Neurocysticercosis	10.6%
49	Ocular Motility Disorders	10.6%
50	Cyclophoria	10.6%
51	Deformity	10.5%
52	Genetic Diseases, Inborn	10.5%
53	Aicardi's syndrome	10.3%
54	Respiratory Distress Syndrome, Newborn	10.2%
55	Holoprosencephaly	10.1%
56	Babesiosis	10%
57	Beckwith-Wiedemann Syndrome	10%
58	Wolf-Hirschhorn Syndrome	10%
59	Meningitis, Bacterial	9.9%
60	Meningitis, Fungal	9.9%
61	Central Nervous System Bacterial Infections	9.9%
62	Cerebral Ventriculitis	9.8%
63	Dandy-Walker Syndrome	9.3%
64	Cri-du-Chat Syndrome	9.2%
65	Down Syndrome	9.2%
66	Pneumocephalus	9.2%
67	Poliomyelitis	9.2%
68	Trisomy 21	9.2%
69	Sjogren-Larsson Syndrome	9.1%
70	Multiple System Atrophy	9.1%
71	Hyperkeratosis, Epidermolytic	8.8%
72	Ophthalmia Neonatorum	8.7%
73	Fragile X Syndrome	8.5%
74	Alstrom Syndrome	8.4%
75	Nesidioblastosis	8.4%
76	Fetal Diseases	8.4%
77	Kernicterus	8.3%
78	Hyaline Membrane Disease	8.3%
79	Dystonia Musculorum Deformans	8.2%
80	Creutzfeldt-Jakob disease	8.2%
81	Rubinstein-Taybi Syndrome	8.1%
82	Prader-Willi Syndrome	8%
83	Stiff-Person Syndrome	8%
84	Parkinsonian Disorders	7.9%
85	Hepatolenticular Degeneration	7.9%
86	Helminthiasis	7.9%
87	CHARGE Syndrome	7.8%
88	Leishmaniasis	7.8%
89	Cockayne Syndrome	7.6%
90	Ectodermal Dysplasia	7.5%
91	Aplasia Cutis Congenita	7.5%
92	Tuberculosis, Meningeal	7.5%
93	Entamoebiasis	7.5%
94	Malaria, Falciparum	7.5%
95	Malaria, Vivax	7.5%
96	Trypanosomiasis	7.5%
97	Anencephaly	7.4%
98	Cranial nerve diseases	7.4%
99	Demyelinating Diseases	7.4%
100	Demyelination	7.4%
101	Neuromuscular Diseases	7.4%
102	Chronobiology Disorders	7.4%
103	Dural Arteriovenous Fistula	7.4%
104	Kartagener Syndrome	7.3%
105	Scrapie	7.2%
106	Limbic Encephalitis	7.2%
107	Lupus Vasculitis, Central Nervous System	7.1%
108	Hydranencephaly	7.1%
109	Neural Tube Defects	7.1%
110	Tethered Cord Syndrome	7.1%
111	Iniencephaly	7.1%
112	Craniorachischisis	7.1%
113	Exencephaly	7.1%
114	Septo-Optic Dysplasia	7.1%
115	Cortical Dysplasia	7.1%
116	Myasthenic Syndromes, Congenital	7.1%
117	Malformations of Cortical Development	7.1%
118	Tuberous Sclerosis	7%
119	Leukoencephalopathy, Progressive Multifocal	7%
120	Spinal Cord Injuries	7%
121	Spinal Muscular Atrophy	6.9%
122	Progressive Muscular Atrophy	6.9%
123	Subacute Combined Degeneration	6.9%
124	Tuberculosis, Central Nervous System	6.9%
125	Lewy Body Disease	6.8%
126	Nail-Patella Syndrome	6.8%
127	Abnormalities, Drug-Induced	6.8%
128	Situs Inversus	6.8%
129	Huntington Disease	6.7%
130	Myelitis, Transverse	6.7%
131	Asterixis	6.7%
132	Ballismus	6.7%
133	Acanthamoeba Keratitis	6.7%
134	Parkinson Disease	6.6%
135	Classical Lissencephalies and Subcortical Band Heterotopias	6.6%
136	Parasitic Diseases, Animal	6.5%
137	Refsum Disease	6.5%
138	Marfan Syndrome	6.4%
139	Williams Syndrome	6.3%
140	Liver Diseases, Parasitic	6.3%
141	Intestinal Diseases, Parasitic	6.2%
142	Pregnancy Complications, Parasitic	6.2%
143	Akinetic Mutism	6.2%
144	Anoxic Encephalopathy	6.2%
145	Arachnoiditis	6.2%
146	Basal Ganglia Diseases	6.2%
147	Brain Damage, Chronic	6.2%
148	Cerebellar Diseases	6.2%
149	Encephalitis	6.2%
150	Encephalomalacia	6.2%
151	Epilepsy	6.2%
152	Hydrocephalus	6.2%
153	Congenital Hydrocephalus	6.2%
154	Hypothalamic Diseases	6.2%
155	Aseptic Meningitis	6.2%
156	Syringomyelia	6.2%
157	Thalamic Diseases	6.2%
158	Intracranial Hypertension	6.2%
159	Aura	6.2%
160	Leukoencephalopathy	6.2%
161	Essential Tremor	6.2%
162	Neuroaxonal Dystrophies	6.2%
163	Familial Tremor	6.2%
164	Headache Disorders	6.2%
165	Intracranial Hypotension	6.2%
166	Brain Edema	6.2%
167	Brain Hypoxia	6.2%
168	Aqueductal Stenosis	6.2%
169	Pneumorrhachis	6.2%
170	Writer's Cramp	6.2%
171	Amyotrophic Lateral Sclerosis	6.2%
172	Central Nervous System Cysts	6.2%
173	Parasitemia	6.2%
174	Adrenoleukodystrophy	6.2%
175	Motor Neuron Disease	6.1%
176	Trauma, Nervous System	6.1%
177	Canavan Disease	6.1%
178	Alexander Disease	6.1%
179	Charcot-Marie-Tooth Disease	6.1%
180	Muscular Dystrophy, Duchenne	6.1%
181	Marchiafava-Bignami Disease	6%
182	Menkes Kinky Hair Syndrome	6%
183	Chronic Fatigue Syndrome	6%
184	Rett Syndrome	6%
185	Nervous System Neoplasms	6%
186	Neurologic Manifestations	6%
187	Neurotoxicity Syndromes	6%
188	Trichomonas Vaginitis	5.9%
189	Meige Syndrome	5.9%
190	Mucopolysaccharidosis II	5.9%
191	Liver Abscess, Amebic	5.8%
192	Smith-Lemli-Opitz Syndrome	5.8%
193	Neuroaspergillosis	5.8%
194	Progressive supranuclear palsy	5.7%
195	Helminthiasis, Animal	5.7%
196	Lafora Disease	5.7%
197	Unverricht-Lundborg Syndrome	5.7%
198	Friedreich Ataxia	5.7%
199	Anemia, Sickle Cell	5.7%
200	Thalassemia	5.7%
201	Albinism	5.6%
202	Polycystic Kidney Diseases	5.6%
203	Eye Abnormalities	5.6%
204	Neoplastic Syndromes, Hereditary	5.6%
205	Cardiovascular Abnormalities	5.6%
206	Myotonic Dystrophy	5.6%
207	Brain Injuries	5.5%
208	Primary Ciliary Dyskinesia	5.5%
209	Brain Neoplasms	5.5%
210	Spinal Cord Neoplasms	5.5%
211	Skin Abnormalities	5.5%
212	Lymphatic Abnormalities	5.5%
213	Congenital Microtia	5.5%
214	Opportunistic Infections	5.4%
215	Multiple Epiphyseal Dysplasia	5.4%
216	Osteochondrodysplasias	5.4%
217	Pelger-Huet Anomaly	5.4%
218	Werner Syndrome	5.4%
219	Meningitis, Cryptococcal	5.4%
220	Striatonigral Degeneration	5.4%
221	Subacute Sclerosing Panencephalitis	5.4%
222	Congenital diaphragmatic hernia	5.4%
223	Meningitis, Listeria	5.3%
224	Meningitis, Haemophilus	5.3%
225	Meningitis, Pneumococcal	5.3%
226	Neuronal Ceroid-Lipofuscinoses	5.3%
227	Muscular Dystrophy	5.3%
228	Restless Legs Syndrome	5.3%
229	Maxillofacial Abnormalities	5.3%
230	Ataxia Telangiectasia	5.2%
231	Dextrocardia	5.2%
232	Pseudorabies	5.2%
233	Microcephaly	5.1%
234	Macrocephaly	5.1%
235	Retinal Dysplasia	5.1%
236	Dementia, Vascular	5.1%
237	Aniridia	5.1%
238	Polyradiculoneuropathy	5.1%
239	Polyradiculoneuritis	5.1%
240	Brain Diseases, Metabolic	5.1%
241	Cerebrovascular Disorders	5.1%
242	Cerebrovascular Insufficiency	5.1%
243	Dementia	5.1%
244	Conus Medullaris Syndrome	5.1%
245	Spinal Cord Vascular Diseases	5.1%
246	Sleep Wake Disorders	5%
247	Akathisia, Drug-Induced	5%
248	Fabry Disease	5%
249	Neuroleptic Malignant Syndrome	5%
250	Myelinolysis, Central Pontine	5%
251	Epidermolysis Bullosa	5%
252	Familial Mediterranean Fever	5%
253	Prune Belly Syndrome	5%
254	Twins, Conjoined	5%
255	Waardenburg Syndrome	5%
256	Brain Diseases, Metabolic, Inborn	5%
257	Meningomyelocele	5%
258	Spina Bifida	5%
259	Blackwater Fever	4.9%
260	Leishmaniasis, Visceral	4.9%
261	African Trypanosomiasis	4.9%
262	Chagas Disease	4.9%
263	Basal Ganglia Cerebrovascular Disease	4.9%
264	Leishmaniasis, Cutaneous	4.9%
265	Posterior Leukoencephalopathy Syndrome	4.9%
266	Posterior reversible encephalopathy syndrome	4.9%
267	Epilepsy, Post-Traumatic	4.9%
268	Neurosyphilis	4.9%
269	Amyloid Neuropathies, Familial	4.9%
270	Porencephaly	4.9%
271	Zellweger Syndrome	4.8%
272	Myotonia Congenita	4.7%
273	Ophthalmoplegic Migraine	4.7%
274	Autonomic Dysreflexia	4.7%
275	Complex Regional Pain Syndromes	4.7%
276	Shy-Drager Syndrome	4.7%
277	Galactosemias	4.7%
278	Urea Cycle Disorders, Inborn	4.7%
279	Tyrosinemias	4.7%
280	Urogenital Abnormalities	4.7%
281	Opsoclonus-Myoclonus Syndrome	4.7%
282	Turner Syndrome	4.7%
283	Sickle Cell Trait	4.6%
284	Dwarfism	4.6%
285	Polycystic Kidney, Autosomal Dominant	4.6%
286	MPTP Poisoning	4.6%
287	Glycogen storage disease type II	4.6%
288	Kallmann Syndrome	4.6%
289	Brain Death	4.5%
290	Fascioliasis	4.5%
291	Fetal Growth Retardation	4.5%
292	Larva Migrans	4.5%
293	Osteogenesis Imperfecta	4.5%
294	Fetal Hypoxia	4.5%
295	Fetal Alcohol Spectrum Disorders	4.5%
296	Acrocephalosyndactylia	4.5%
297	Wiskott-Aldrich Syndrome	4.4%
298	Klinefelter Syndrome	4.4%
299	Dyskinesia, Drug-Induced	4.3%
300	Lyme Neuroborreliosis	4.3%
301	Amblyopia	4.3%
302	Cestode Infections	4.2%
303	Nematode infections	4.2%
304	Trematode Infections	4.2%
305	Scimitar Syndrome	4.1%
306	Meningocele	4.1%
307	Encephalocele	4.1%
308	Duane Retraction Syndrome	4.1%
309	Craniosynostosis	4.1%
310	Syndactyly	4.1%
311	Vascular Headaches	4.1%
312	Brachycephaly	4.1%
313	Homocystinuria	4.1%
314	Optic Atrophy, Hereditary, Leber	4.1%
315	Antley-Bixler Syndrome Phenotype	4.1%
316	Hypoxia-Ischemia, Brain	4.1%
317	Leigh Disease	4.1%
318	Anophthalmos	4%
319	Anus, Imperforate	4%
320	Microphthalmos	4%
321	Limb Deformities, Congenital	4%
322	Craniofacial Abnormalities	4%
323	Anorectal Malformations	4%
324	Pseudoxanthoma Elasticum	4%
325	Amino Acid Metabolism, Inborn Errors	4%
326	Bloom Syndrome	4%
327	Carbohydrate Metabolism, Inborn Errors	4%
328	Metal Metabolism, Inborn Errors	4%
329	Progeria	4%
330	Lysosomal Storage Diseases	4%
331	Cytochrome-c Oxidase Deficiency	4%
332	Peroxisomal Disorders	4%
333	Peripheral Nerve Injuries	4%
334	Cerebellar Neoplasms	3.9%
335	Dermal Sinus	3.9%
336	Myasthenia Gravis	3.9%
337	Spina Bifida Cystica	3.9%
338	Spina Bifida Occulta	3.9%
339	Lissencephaly	3.9%
340	Polymicrogyria	3.9%
341	Pachygyria	3.9%
342	Schizencephaly	3.9%
343	Periventricular Nodular Heterotopia	3.9%
344	Leukoencephalitis, Acute Hemorrhagic	3.9%
345	Myoclonic Epilepsy	3.9%
346	Epilepsy, Temporal Lobe	3.9%
347	Epilepsy, Rolandic	3.9%
348	Benign Rolandic Epilepsy	3.9%
349	Echinococcosis, Hepatic	3.9%
350	Central Cord Syndrome	3.9%
351	Gaucher Disease	3.9%
352	Autoimmune Lymphoproliferative Syndrome	3.9%
353	Presenile dementia	3.9%
354	Senile dementia	3.9%
355	Chorea	3.8%
356	Welander Distal Myopathy	3.8%
357	Chorioamnionitis	3.8%
358	Dysautonomia	3.8%
359	Vagus Nerve Disorder	3.8%
360	Glossopharyngeal Neuralgia	3.8%
361	Abducens Nerve Diseases	3.8%
362	Heavy Metal Poisoning, Nervous System	3.8%
363	Neuromuscular Junction Diseases	3.8%
364	Tauopathies	3.8%
365	Trochlear Nerve Diseases	3.8%
366	Peripheral Nervous System Diseases	3.8%
367	Angioedemas, Hereditary	3.8%
368	Vasculitis, Central Nervous System	3.8%
369	Encephalomyelitis, Acute Disseminated	3.8%
370	Cleft Palate	3.7%
371	Cerebral Palsy	3.7%
372	Epilepsies, Partial	3.7%
373	Epilepsy, Generalized	3.7%
374	Pseudotumor Cerebri	3.7%
375	Hypertensive Encephalopathy	3.7%
376	Simple Partial Seizures	3.7%
377	Epilepsy, Reflex	3.7%
378	Headache Disorders, Primary	3.7%
379	Headache Disorders, Secondary	3.7%
380	Medication overuse headache	3.7%
381	Noonan Syndrome	3.7%
382	Acute Chest Syndrome	3.7%
383	West Nile Fever	3.7%
384	Xeroderma Pigmentosum	3.7%
385	Miller Fisher Syndrome	3.6%
386	Tay-Sachs Disease	3.6%
387	Poland Syndrome	3.6%
388	Mucopolysaccharidosis III	3.6%
389	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.6%
390	Familial Periodic Paralysis	3.6%
391	Toxocariasis	3.5%
392	POEMS Syndrome	3.5%
393	Lambert-Eaton Myasthenic Syndrome	3.5%
394	Jaw Abnormalities	3.5%
395	Guillain-Barre Syndrome	3.5%
396	Amnesia, Transient Global	3.5%
397	Hydrops Fetalis	3.5%
398	Sleep Disorders, Circadian Rhythm	3.5%
399	Onchocerciasis	3.4%
400	Niemann-Pick Disease, Type C	3.4%
401	Dirofilariasis	3.4%
402	Blepharophimosis	3.4%
403	Laryngostenosis	3.4%
404	Mouth Abnormalities	3.4%
405	Cutis Laxa	3.4%
406	Esophageal Atresia	3.4%
407	Intestinal Atresia	3.4%
408	Horseshoe Kidney	3.4%
409	Pectus excavatum	3.4%
410	Klippel-Feil Syndrome	3.3%
411	Retinitis Pigmentosa	3.3%
412	Gastroschisis	3.3%
413	Synostosis	3.3%
414	Pigmentary retinopathy	3.3%
415	Botulism	3.3%
416	Acrodermatitis	3.3%
417	Lymphangiectasis, Intestinal	3.3%
418	Porokeratosis	3.3%
419	Gianotti-Crosti Syndrome	3.3%
420	Keratoderma, Palmoplantar	3.3%
421	Abnormalities, Radiation-Induced	3.3%
422	Progressive bulbar palsy	3.3%
423	Bulbar palsy	3.3%
424	Chronic granulomatous disease	3.3%
425	Amelia	3.3%
426	Arachnodactyly	3.3%
427	Ectopia Cordis	3.3%
428	Ectromelia	3.3%
429	Hemimelia	3.3%
430	Phocomelia	3.3%
431	Sirenomelia	3.3%
432	Polydactyly	3.3%
433	Brachydactyly	3.3%
434	Plagiocephaly	3.3%
435	Lower Extremity Deformities, Congenital	3.3%
436	Upper Extremity Deformities, Congenital	3.3%
437	Single umbilical artery	3.3%
438	Paraneoplastic Cerebellar Degeneration	3.3%
439	Basal Cell Nevus Syndrome	3.3%
440	Alkaptonuria	3.3%
441	Glycogen Storage Disease	3.3%
442	Hypophosphatasia	3.3%
443	Propionic acidemia	3.3%
444	Dihydropyrimidine Dehydrogenase Deficiency	3.3%
445	Cystinosis	3.3%
446	Brain Injuries, Diffuse	3.3%
447	Traumatic Brain Injury	3.3%
448	Cerebellar Ataxia	3.3%
449	Supratentorial Neoplasms	3.3%
450	Torticollis	3.3%
451	Hyperphosphaturia	3.2%
452	MELAS Syndrome	3.2%
453	Micrognathism	3.2%
454	Pierre Robin Syndrome	3.2%
455	Myopathy	3.2%
456	Brain Hemorrhage, Traumatic	3.2%
457	Optic Neuropathy	3.2%
458	Strongyle Infections, Equine	3.1%
459	Pituitary Diseases	3.1%
460	Carotid Artery Injuries	3.1%
461	Facial Nerve Diseases	3.1%
462	Craniocerebral Trauma	3.1%
463	Parasomnia	3.1%
464	Dyssomnias	3.1%
465	Olfactory Nerve Injuries	3.1%
466	Vestibulocochlear Nerve Diseases	3%
467	Decerebrate State	3%
468	Hemiparesis	3%
469	Meningism	3%
470	Paresis	3%
471	Seizures	3%
472	Sensation Disorders	3%
473	Central Nervous System Neoplasms	3%
474	Complex partial seizures	3%
475	Monoparesis	3%
476	Neurogenic Inflammation	3%
477	Gait Disorders, Neurologic	3%
478	Neuromuscular Manifestations	3%
479	Causalgia	3%
480	Sweating, Gustatory	3%
481	Auriculotemporal Syndrome	3%
482	Persistent Vegetative State	3%
483	Carotid Artery Diseases	3%
484	Brain Ischemia	3%
485	Cerebrovascular accident	3%
486	Kluver-Bucy Syndrome	3%
487	Vasospasm, Intracranial	3%
488	Spinal Cord Ischemia	3%
489	Intracranial Arterial Diseases	3%
490	Chagas Cardiomyopathy	3%
491	Basal Ganglia Hemorrhage	3%
492	Arthrogryposis	2.9%
493	Choanal Atresia	2.9%
494	Tracheobronchomegaly	2.9%
495	Laryngocele	2.9%
496	Glycogen Storage Disease Type I	2.9%
497	Glycogen Storage Disease Type V	2.9%
498	Juvenile Myoclonic Epilepsy	2.9%
499	Myoclonic Epilepsies, Progressive	2.9%
500	Choledochal Cyst	2.9%
501	Hermaphroditism	2.9%
502	Disorders of Sex Development	2.9%
503	Cryptorchidism	2.9%
504	Porphyrias, Hepatic	2.9%
505	Hypospadias	2.9%
506	Retrognathia	2.9%
507	Horner Syndrome	2.8%
508	Peutz-Jeghers Syndrome	2.8%
509	Thrombasthenia	2.8%
510	Antithrombin III Deficiency	2.8%
511	Protein C Deficiency	2.8%
512	Superinfection	2.8%
513	Neuromyelitis Optica	2.8%
514	Afibrinogenemia	2.8%
515	Factor VII Deficiency	2.8%
516	Factor X Deficiency	2.8%
517	Factor XII Deficiency	2.8%
518	Hemophilia A	2.8%
519	Pituitary Apoplexy	2.8%
520	Activated Protein C Resistance	2.8%
521	Factor II deficiency	2.8%
522	Factor VIII Deficiency	2.8%
523	Factor V deficiency	2.8%
524	Factor XI Deficiency	2.8%
525	Hypoprothrombinemias	2.8%
526	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.8%
527	Fanconi Anemia	2.8%
528	Hypokalemic periodic paralysis	2.8%
529	Anemia, Diamond-Blackfan	2.8%
530	Brain Infarction	2.8%
531	Aortic coarctation	2.8%
532	Cor Triatriatum	2.8%
533	Coronary Vessel Anomalies	2.8%
534	Dental Enamel Hypoplasia	2.8%
535	Patent ductus arteriosus	2.8%
536	Ebstein Anomaly	2.8%
537	Heart Septal Defects	2.8%
538	Hypodontia	2.8%
539	Macrostomia	2.8%
540	Microstomia	2.8%
541	Multiple Sclerosis	2.8%
542	Tetralogy of Fallot	2.8%
543	Transposition of Great Vessels	2.8%
544	Hypoplastic Left Heart Syndrome	2.8%
545	May-Thurner Syndrome	2.8%
546	Craniofacial Dysostosis	2.7%
547	Hypolipoproteinemias	2.7%
548	Papillon-Lefevre Disease	2.7%
549	Wolff-Parkinson-White Syndrome	2.7%
550	Hyperlipidemia, Familial Combined	2.7%
551	Hyperlipoproteinemia Type III	2.7%
552	Pituitary Adenoma	2.7%
553	Pituitary Neoplasms	2.7%
554	Facial Nerve Injuries	2.7%
555	Hyperandrogenism	2.6%
556	Reflex Sympathetic Dystrophy	2.6%
557	Nocturnal Myoclonus Syndrome	2.6%
558	Pupil Disorders	2.6%
559	Neurobehavioral Manifestations	2.6%
560	Prognathism	2.6%
561	Multiple Endocrine Neoplasia	2.6%
562	Laryngomalacia	2.6%
563	Paraneoplastic Encephalomyelitis	2.5%
564	Pectus carinatum	2.5%
565	Uveomeningoencephalitic Syndrome	2.5%
566	Sturge-Weber Syndrome	2.5%
567	Vertigo	2.5%
568	Alcohol-Induced Disorders, Nervous System	2.5%
569	Bladder Exstrophy	2.5%
570	Congenital Hypothyroidism	2.5%
571	Epispadias	2.5%
572	Dermatitis, Atopic	2.5%
573	Jet Lag Syndrome	2.5%
574	Diphyllobothriasis	2.5%
575	Echinococcosis	2.5%
576	Hymenolepiasis	2.5%
577	Mite Infestations	2.5%
578	Myiasis	2.5%
579	Opisthorchiasis	2.5%
580	Schistosomiasis	2.5%
581	Tick Infestations	2.5%
582	Secernentea Infections	2.5%
583	Multicystic Dysplastic Kidney	2.5%
584	Reye Syndrome	2.5%
585	Intracranial Embolism and Thrombosis	2.5%
586	Hepatic Encephalopathy	2.5%
587	Mitochondrial Encephalomyopathies	2.5%
588	Post-Traumatic Headache	2.5%
589	Tension Headache	2.5%
590	Epilepsy, Complex Partial	2.5%
591	Migraine Disorders	2.5%
592	Abdominal Migraine	2.5%
593	Status Migrainosus	2.5%
594	Cervicogenic Headache	2.5%
595	Aortopulmonary Septal Defect	2.4%
596	Double Outlet Right Ventricle	2.4%
597	Endocardial Cushion Defects	2.4%
598	Myocardial bridging	2.4%
599	Aorticopulmonary Septal Defect	2.4%
600	Tardive Dyskinesia	2.4%
601	Hypoalphalipoproteinemias	2.4%
602	Ophthalmoplegia	2.4%
603	External Ophthalmoplegia	2.4%
604	Myasthenia Gravis, Autoimmune, Experimental	2.4%
605	Long QT Syndrome	2.4%
606	Platybasia	2.4%
607	Tricuspid Atresia	2.4%
608	Arrhythmogenic Right Ventricular Dysplasia	2.4%
609	Gonadal Dysgenesis	2.4%
610	Bronchomalacia	2.4%
611	Adrenogenital Syndrome	2.4%
612	Tracheomalacia	2.4%
613	Ovotesticular Disorders of Sex Development	2.4%
614	Lactose Intolerance	2.3%
615	Variegate Porphyria	2.3%
616	Acute intermittent porphyria	2.3%
617	Porphyria Cutanea Tarda	2.3%
618	Hyperhomocysteinemia	2.3%
619	Renal Aminoacidurias	2.3%
620	Fanconi Syndrome	2.3%
621	Pseudohypoaldosteronism	2.3%
622	Liddle Syndrome	2.3%
623	Hyperlipoproteinemia Type IV	2.3%
624	Hyperlipoproteinemia Type V	2.3%
625	Truncus Arteriosus, Persistent	2.3%
626	Goldenhar Syndrome	2.3%
627	Putaminal Hemorrhage	2.3%
628	Vertebral Artery Dissection	2.3%
629	Waterhouse-Friderichsen Syndrome	2.2%
630	Behcet Syndrome	2.2%
631	Voice Disorders	2.2%
632	Voice Disturbance	2.2%
633	Acrodynia	2.2%
634	Auditory Perceptual Disorders	2.2%
635	Diffuse Axonal Injury	2.2%
636	Brain Stem Neoplasms	2.2%
637	Infarction, Middle Cerebral Artery	2.1%
638	Infarction, Anterior Cerebral Artery	2.1%
639	Infarction, Posterior Cerebral Artery	2.1%
640	Moyamoya Disease	2.1%
641	Vocal Cord Paralysis	2.1%
642	AIDS-Related Opportunistic Infections	2.1%
643	Mandibulofacial Dysostosis	2.1%
644	Romano-Ward Syndrome	2.1%
645	Frontotemporal dementia	2.1%
646	Gout	2.1%
647	Cystinuria	2.1%
648	Neuritis	2.1%
649	Polyneuritis	2.1%
650	Radiculitis	2.1%
651	Polyneuropathy	2.1%
652	Mononeuritis	2.1%
653	Mononeuropathies	2.1%
654	Brachial Plexus Neuropathies	2.1%
655	Radiculopathy	2.1%
656	Mononeuropathy Multiplex	2.1%
657	Nerve Root Compression	2.1%
658	Cerebral Infarction	2.1%
659	Brain Stem Infarctions	2.1%
660	Multiple Endocrine Neoplasia Type 1	2.1%
661	Pseudohypoparathyroidism	2.1%
662	Denys-Drash Syndrome	2%
663	Renal tubular acidosis	2%
664	Empty Sella Syndrome	2%
665	Hyperpituitarism	2%
666	Hypopituitarism	2%
667	Hypophysitis	2%
668	Talipes	2%
669	Brain Concussion	2%
670	Lice Infestations	2%
671	Brachial Plexus Neuritis	2%
672	Neuralgic Amyotrophy	2%
673	Cerebral Arterial Diseases	2%
674	Vertebrobasilar Insufficiency	2%
675	Anterior Spinal Artery Syndrome	2%
676	Basilar Artery Stenosis	2%
677	Vertebral Artery Stenosis	2%
678	Intracranial Hemorrhage, Hypertensive	2%
679	Transient Cerebral Ischemia	2%
680	Subarachnoid Hemorrhage, Traumatic	1.9%
681	Carotid Artery, Internal, Dissection	1.9%
682	Familial Hypophosphatemic Rickets	1.9%
683	Congenital clubfoot	1.9%
684	Vertical Talus	1.9%
685	Alice in Wonderland Syndrome	1.9%
686	Cerebrospinal Fluid Otorrhea	1.9%
687	Cerebrospinal Fluid Rhinorrhea	1.9%
688	Neuritis, Autoimmune, Experimental	1.9%
689	Gait Ataxia	1.9%
690	Reflex, Abnormal	1.9%
691	Hyporeflexia	1.9%
692	Hyperreflexia	1.9%
693	Brain Contusion	1.9%
694	Wernicke Encephalopathy	1.8%
695	AIDS Dementia Complex	1.8%
696	Cluster Headache	1.8%
697	Migraine with Aura	1.8%
698	Familial Hemiplegic Migraine	1.8%
699	Chronic Paroxysmal Hemicrania	1.8%
700	SUNCT Syndrome	1.8%
701	Paroxysmal Hemicrania	1.8%
702	Arthritis, Gouty	1.8%
703	Alcohol Withdrawal Seizures	1.8%
704	Giant Cell Arteritis	1.8%
705	Temporal Arteritis	1.8%
706	Nephroblastoma	1.8%
707	Coma, Post-Head Injury	1.8%
708	Lateral Medullary Syndrome	1.7%
709	Myositis	1.7%
710	Optic Atrophy	1.7%
711	Optic Neuritis	1.7%
712	Papilledema	1.7%
713	Strabismus	1.7%
714	Tolosa-Hunt Syndrome	1.7%
715	Isaacs syndrome	1.7%
716	Arsenic Poisoning	1.7%
717	Myotonic Disorders	1.7%
718	Diabetic Neuropathies	1.7%
719	Facial Injuries	1.7%
720	Facial Neuralgia	1.7%
721	Diabetic Amyotrophy	1.7%
722	Diabetic Autonomic Neuropathy	1.7%
723	Sleep Talking	1.7%
724	Manganese Poisoning	1.7%
725	Sleep Disorders, Intrinsic	1.7%
726	Orthostatic intolerance	1.7%
727	Anosmia	1.7%
728	Ataxia	1.7%
729	Athetosis	1.7%
730	Catalepsy	1.7%
731	Dystonia	1.7%
732	Hemiplegia	1.7%
733	Locked-In Syndrome	1.7%
734	Meningeal Neoplasms	1.7%
735	Muscle Hypertonia	1.7%
736	Muscle hypotonia	1.7%
737	Myoclonus	1.7%
738	Myotonia	1.7%
739	Neuralgia	1.7%
740	Paraplegia	1.7%
741	Pseudobulbar Palsy	1.7%
742	Quadriplegia	1.7%
743	Spasm	1.7%
744	Spastic Paraplegia	1.7%
745	Status Epilepticus	1.7%
746	Taste Disorders	1.7%
747	Tremor	1.7%
748	Monoplegia	1.7%
749	Hypokinesia	1.7%
750	Paraparesis	1.7%
751	Bradykinesia	1.7%
752	Waxy flexibility	1.7%
753	Action Tremor	1.7%
754	Resting Tremor	1.7%
755	Dysosmia	1.7%
756	Quadriparesis	1.7%
757	Mercury Poisoning, Nervous System	1.7%
758	Olfaction Disorders	1.7%
759	Myokymia	1.7%
760	Lead Poisoning, Nervous System	1.7%
761	Vestibular Neuronitis	1.7%
762	Somatosensory Disorders	1.7%
763	Neuropathic pain	1.7%
764	Hyperkinesia	1.7%
765	Intention tremor	1.7%
766	Cysticercosis	1.6%
767	Hypodermyiasis	1.6%
768	Schistosomiasis japonica	1.6%
769	Schistosomiasis mansoni	1.6%
770	Sparganosis	1.6%
771	Ascaridida Infections	1.6%
772	Oxyurida Infections	1.6%
773	Carotid Stenosis	1.6%
774	Intracranial Aneurysm	1.6%
775	Akathisia	1.6%
776	Restlessness	1.6%
777	Psychomotor Agitation	1.6%
778	Arteriovenous fistula	1.6%
779	Tarsal Tunnel Syndrome	1.6%
780	Cauda Equina Syndrome	1.6%
781	Intracranial Arteriosclerosis	1.6%
782	Cerebral Atherosclerosis	1.6%
783	Subarachnoid Hemorrhage	1.6%
784	Multiple Sclerosis, Chronic Progressive	1.6%
785	Multiple Sclerosis, Relapsing-Remitting	1.6%
786	Cerebral Arteriosclerosis	1.6%
787	Cerebral Hemorrhage	1.6%
788	Adenomatous Polyposis Coli	1.6%
789	Cerebral Thrombosis	1.6%
790	Intracranial Embolism	1.6%
791	Intracranial Thrombosis	1.6%
792	Glycosuria, Renal	1.6%
793	Choroid Plexus Papilloma	1.6%
794	Hyperprolactinemia	1.5%
795	Subclavian Steal Syndrome	1.5%
796	Pick Disease of the Brain	1.5%
797	Hand-Arm Vibration Syndrome	1.4%
798	Vision Disorders	1.4%
799	Metamorphopsia	1.4%
800	Visual Impairment	1.4%
801	Gait Apraxia	1.4%
802	Fibromyalgia	1.4%
803	Optic Neuropathy, Ischemic	1.4%
804	Anterior Ischemic Optic Neuropathy	1.4%
805	Medial Tibial Stress Syndrome	1.4%
806	Facial Hemiatrophy	1.4%
807	Melkersson-Rosenthal Syndrome	1.4%
808	Mitochondrial Myopathies	1.4%
809	Anisocoria	1.4%
810	Confusion	1.4%
811	Facial paralysis	1.4%
812	Lethargy	1.4%
813	Memory Disorders	1.4%
814	Muscle Cramp	1.4%
815	Perceptual Disorders	1.4%
816	Psychomotor Disorders	1.4%
817	Tonic Pupil	1.4%
818	Eosinophilia-Myalgia Syndrome	1.4%
819	Anhedonia	1.4%
820	Disorientation	1.4%
821	Facial Paresis	1.4%
822	Memory Loss	1.4%
823	Hemisensory Neglect	1.4%
824	Dysacusis	1.4%
825	Carotid Artery Thrombosis	1.4%
826	Sleep Bruxism	1.4%
827	Muscular Atrophy	1.4%
828	Respiratory Paralysis	1.4%
829	Tetany	1.4%
830	Carpal Tunnel Syndrome	1.4%
831	Optic Nerve Glioma	1.4%
832	Acoustic Neuroma	1.4%
833	neurofibroma	1.4%
834	Sciatica	1.4%
835	Hematoma, Subdural	1.4%
836	Hematoma, Epidural, Cranial	1.4%
837	Acromegaly	1.2%
838	Sciatic Neuropathy	1.2%
839	Ulnar Neuropathies	1.2%
840	Lesion of Sciatic Nerve	1.2%
841	Ulnar Neuritis	1.2%
842	Radial nerve compression	1.2%
843	Radial Tunnel Syndrome	1.2%
844	Peroneal Neuropathies	1.2%
845	Radial Neuropathy	1.2%
846	Median Neuropathy	1.2%
847	Sciatic Nerve Palsy	1.2%
848	Femoral Neuropathy	1.2%
849	Tibial Neuropathy	1.2%
850	Ulnar Nerve Palsy	1.2%
851	Postural Orthostatic Tachycardia Syndrome	1.2%
852	Radial nerve palsy	1.2%
853	Ascariasis	1.2%
854	Filariasis	1.2%
855	Gnathostomiasis	1.2%
856	Hookworm Infections	1.2%
857	Oxyuriasis	1.2%
858	Strongyloidiasis	1.2%
859	Trichinellosis	1.2%
860	Trichostrongyloidiasis	1.2%
861	Cerebral Amyloid Angiopathy	1.2%
862	Sinus Thrombosis, Intracranial	1.2%
863	Consciousness Disorders	1.2%
864	Mental Retardation	1.2%
865	Muscle Weakness	1.2%
866	Depressed Level of Consciousness	1.2%
867	Mental deficiency	1.2%
868	Intellectual Disability	1.2%
869	Bell Palsy	1.2%
870	Catatonia	1.2%
871	Herpes Zoster Oticus	1.2%
872	Aphonia	1.2%
873	Sleep Deprivation	1.2%
874	Dysphonia	1.2%
875	Cubital Tunnel Syndrome	1.1%
876	Myalgia	1%
877	Hematoma, Subdural, Intracranial	1%
878	Hematoma, Subdural, Chronic	1%
879	Hematoma, Subdural, Acute	1%
880	Loiasis	1%
881	Enterobiasis	1%
882	Cavernous Sinus Thrombosis	1%
883	Sagittal Sinus Thrombosis	1%
884	Thoracic Outlet Syndrome	1%
885	Esotropia	1%
886	Exotropia	1%
887	Hypotension, Orthostatic	1%
888	Sleep Apnea Syndromes	1%
889	Polymyositis	1%
890	Post-Exercise Hypotension	1%
891	Disorders of Excessive Somnolence	1%
892	Sleep Initiation and Maintenance Disorders	1%
893	Night Terrors	1%
894	Somnambulism	1%
895	Trigeminal Nerve Disorder	1%
896	Transient Insomnia	1%
897	Sleep Paralysis	1%
898	Chronic Insomnia	1%
899	REM Sleep Behavior Disorder	1%
900	Hypersomnia	1%
901	Dysgeusia	1%
902	Formication	1%
903	Hyperalgesia	1%
904	Hyperesthesia	1%
905	Hypesthesia	1%
906	Language Disorders	1%
907	Numbness	1%
908	Paresthesia	1%
909	Paraparesis, Spastic	1%
910	Trismus	1%
911	Epilepsia Partialis Continua	1%
912	Hypogeusia	1%
913	Meningeal Carcinomatosis	1%
914	Brown-Sequard Syndrome	1%
915	Lockjaw	1%
916	Allodynia	1%
917	Lead Poisoning, Nervous System, Childhood	1%
918	Lead Poisoning, Nervous System, Adult	1%
919	Ageusia	1%
920	Hoarseness	0.9%
921	Prolactinoma	0.9%
922	Growth Hormone-Secreting Pituitary Adenoma	0.9%
923	Alcohol Withdrawal Delirium	0.9%
924	Nelson Syndrome	0.9%
925	Eye Injuries	0.8%
926	Orbital Myositis	0.8%
927	Diplopia	0.8%
928	Muscle Rigidity	0.8%
929	Muscle Spasticity	0.8%
930	Scotoma	0.8%
931	Photophobia	0.8%
932	Cogwheel Rigidity	0.8%
933	Hemifacial Spasm	0.8%
934	Amaurosis	0.8%
935	Blindness	0.8%
936	Nuchal Rigidity	0.8%
937	Pyomyositis	0.8%
938	Agnosia	0.8%
939	Apraxias	0.8%
940	Hallucinations	0.8%
941	Hemianopsia	0.8%
942	Polyradiculopathy	0.8%
943	Hyperacusis	0.8%
944	Tinnitus	0.8%
945	Visual Agnosia	0.8%
946	Anosognosia	0.8%
947	Wernicke-Korsakoff Syndrome	0.8%
948	Phonophobia	0.8%
949	Hearing Loss	0.8%
950	Sarcopenia	0.8%
951	Alexia	0.8%
952	Dyslexia	0.8%
953	Kearns-Sayre syndrome	0.7%
954	Amnesia	0.7%
955	Delirium	0.7%
956	Dissociative Amnesia	0.7%
957	Color blindness	0.7%
958	Global Amnesia	0.7%
959	Meningioma	0.7%
960	Neurofibrosarcoma	0.7%
961	Sleep Apnea, Obstructive	0.7%
962	Sleep Apnea, Central	0.7%
963	Narcolepsy	0.7%
964	Trigeminal Neuralgia	0.7%
965	Kleine-Levin Syndrome	0.7%
966	Agraphia	0.7%
967	Anomia	0.7%
968	Cluttering	0.7%
969	Language Development Disorders	0.7%
970	Speech Disorders	0.7%
971	Syncope	0.7%
972	Stupor	0.7%
973	Dysgraphia	0.7%
974	Presyncope	0.7%
975	Dyslalia	0.7%
976	Phantom pain	0.6%
977	Phantom Limb Pain	0.6%
978	Eye Burns	0.6%
979	Amaurosis Fugax	0.5%
980	Blindness, Cortical	0.5%
981	Dyscalculia	0.5%
982	Deafness	0.5%
983	Hearing Loss, Sudden	0.5%
984	Gerstmann Syndrome	0.5%
985	Hearing Loss, Bilateral	0.5%
986	Hearing Loss, High-Frequency	0.5%
987	Hearing Loss, Mixed Conductive-Sensorineural	0.5%
988	Prosopagnosia	0.5%
989	Apraxia, Ideomotor	0.5%
990	Charles Bonnet Syndrome	0.5%
991	Hearing Loss, Unilateral	0.5%
992	Complete Hearing Loss	0.5%
993	Alien Hand Syndrome	0.5%
994	Deaf Mutism	0.5%
995	Cataplexy	0.5%
996	Aphasia	0.5%
997	Articulation Disorders	0.5%
998	Echolalia	0.5%
999	Stuttering	0.5%
1000	Dysphasia	0.5%
1001	Dermatomyositis	0.5%
1002	Corneal Scar	0.5%
1003	Retrograde amnesia	0.5%
1004	Amnesia, Anterograde	0.5%
1005	Mutism	0.4%
1006	Selective Mutism	0.4%
1007	Dysarthria	0.4%
1008	Corneal Perforation	0.4%
1009	Alexia, Pure	0.3%

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