MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Eosinophilia-Myalgia Syndrome

(UMLS:C0085179)

Definition:: A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
UMLS ID:: C0085179
MeSH ID:: D016603

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.290

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.668.491.050

Classification 3:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.553.231.335

Synonym(s)

Eosinophilia-Myalgia Syndrome

EMS - Eosinophilia myalgia syndrome

Eosinophilia myalgia syndrome

Eosinophilia-myalgia syndrome

eosinophilia myalgia syndrome

eosinophilia-myalgia syndrome

eosinophilia; myalgia syndrome

syndrome; eosinophilia-myalgia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Lansoprazole	9496405	CTD
2	Melatonin	9374988 10085477	CTD
3	Prednisone	12610828	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Myositis	35.4%
2	Myotonic Disorders	35.4%
3	Fibromyalgia	34.3%
4	Medial Tibial Stress Syndrome	29.7%
5	Mitochondrial Myopathies	29.4%
6	Polymyositis	26%
7	Hypereosinophilic syndrome	25%
8	Myotonic Dystrophy	25%
9	Familial Periodic Paralysis	24.9%
10	Isaacs syndrome	24.5%
11	Chronic Fatigue Syndrome	23.1%
12	Contracture	22.1%
13	Muscular Dystrophy	21.9%
14	Orbital Myositis	21.9%
15	Pyomyositis	21.7%
16	Myalgia	21.6%
17	Myofascial Pain Syndromes	20.5%
18	Rhabdomyolysis	20.5%
19	Myotonia Congenita	20.5%
20	Ischemic contracture	20.1%
21	Arthrogryposis	19.7%
22	Hypokalemic periodic paralysis	18.3%
23	Polymyalgia Rheumatica	18.3%
24	Welander Distal Myopathy	17.9%
25	Leukopenia	17.6%
26	Leukostasis	17.6%
27	Mitochondrial Encephalomyopathies	17.4%
28	Eosinophilic Granuloma	16.7%
29	Compartment syndromes	16.6%
30	Tendinitis	16.6%
31	Motor Neuron Disease	16.6%
32	Tendinopathy	16.6%
33	Hip Contracture	16.1%
34	Temporomandibular Joint Dysfunction Syndrome	16.1%
35	Muscle Cramp	15.7%
36	Dermatomyositis	15.7%
37	Neuromuscular Junction Diseases	15.4%
38	Peripheral Nervous System Diseases	15.4%
39	Muscular Dystrophy, Duchenne	15.4%
40	Pulmonary Eosinophilia	15.2%
41	Eosinophilic Pneumonia	15.2%
42	Fibrodysplasia Ossificans Progressiva	15.1%
43	Myoglobinuria	15.1%
44	Myositis Ossificans	15.1%
45	Tenosynovitis	15.1%
46	Disseminated Intravascular Coagulation	15.1%
47	Protein S Deficiency	15.1%
48	Muscle Rigidity	15%
49	Muscle Spasticity	15%
50	Cogwheel Rigidity	15%
51	Nuchal Rigidity	15%
52	Leukocytosis	14.3%
53	Pelger-Huet Anomaly	14.3%
54	Pleocytosis	14.3%
55	Stiff-Person Syndrome	13.7%
56	Muscle Weakness	13.6%
57	Thrombocythemia, Essential	13.5%
58	Temporomandibular Joint Disorders	13.3%
59	Leukemoid Reaction	13.2%
60	Anemia	12.8%
61	Blood Coagulation Disorders	12.8%
62	Blood Platelet Disorders	12.8%
63	Bone Marrow Diseases	12.8%
64	Hemorrhagic Disorders	12.8%
65	Methemoglobinemia	12.8%
66	Pancytopenia	12.8%
67	Polycythemia	12.8%
68	Sulfhemoglobinemia	12.8%
69	Thrombophilia	12.8%
70	Erythrocytosis	12.8%
71	Complex Regional Pain Syndromes	12.2%
72	Causalgia	12.2%
73	Anterior Compartment Syndrome	12.1%
74	Enthesopathy	12.1%
75	Abdominal Compartment Syndrome	12.1%
76	Brachial Plexus Neuritis	11.9%
77	Neuralgic Amyotrophy	11.9%
78	Agranulocytosis	11.7%
79	Lymphocytosis	11.7%
80	Musculoskeletal Pain	11.5%
81	Infectious Mononucleosis	11.4%
82	Poliomyelitis	11.4%
83	Thrombasthenia	11.4%
84	Antithrombin III Deficiency	11.4%
85	Protein C Deficiency	11.4%
86	Guillain-Barre Syndrome	11.4%
87	Spinal Muscular Atrophy	11.2%
88	Progressive Muscular Atrophy	11.2%
89	Osteoarthropathy, Secondary Hypertrophic	11%
90	Fasciitis, Plantar	11%
91	Tarsal Tunnel Syndrome	10.9%
92	Cauda Equina Syndrome	10.9%
93	Progressive bulbar palsy	10.7%
94	Bulbar palsy	10.7%
95	Transfusion Reaction	10.6%
96	Hypotensive Transfusion Reaction	10.6%
97	Bone Diseases	10.6%
98	Fasciitis	10.6%
99	Foot Deformities	10.6%
100	Arthropathy	10.6%
101	Pregnancy Complications, Hematologic	10.3%
102	Hematologic Neoplasms	10.3%
103	Peripheral Nerve Injuries	10.3%
104	Polyradiculoneuropathy	10.2%
105	Polyradiculoneuritis	10.2%
106	Myasthenia Gravis	10.2%
107	MELAS Syndrome	10.1%
108	Neuritis	10.1%
109	Polyneuritis	10.1%
110	Radiculitis	10.1%
111	Polyneuropathy	10.1%
112	Mononeuritis	10.1%
113	Mononeuropathies	10.1%
114	Brachial Plexus Neuropathies	10.1%
115	Radiculopathy	10.1%
116	Mononeuropathy Multiplex	10.1%
117	Nerve Root Compression	10.1%
118	Dupuytren Contracture	10.1%
119	Bone Marrow Neoplasms	10.1%
120	Amyotrophic Lateral Sclerosis	10%
121	Thrombocytosis	10%
122	Vitamin K Deficiency	10%
123	Afibrinogenemia	10%
124	Factor VII Deficiency	10%
125	Factor X Deficiency	10%
126	Factor XII Deficiency	10%
127	Hemophilia A	10%
128	Activated Protein C Resistance	10%
129	Factor II deficiency	10%
130	Factor VIII Deficiency	10%
131	Factor V deficiency	10%
132	Factor XI Deficiency	10%
133	Hypoprothrombinemias	10%
134	Osteoarthritis, Spine	9.6%
135	Lymphopenia	9.5%
136	Wiskott-Aldrich Syndrome	9.4%
137	Kearns-Sayre syndrome	9.4%
138	Pectus carinatum	9.4%
139	Job Syndrome	9.3%
140	Osteochondritis	9.1%
141	Carpal Tunnel Syndrome	9.1%
142	Metatarsalgia	9.1%
143	Sciatica	9%
144	Cranial nerve diseases	8.8%
145	Demyelinating Diseases	8.8%
146	Demyelination	8.8%
147	Chronobiology Disorders	8.8%
148	Jaw Diseases	8.8%
149	Neutropenia	8.7%
150	Reflex Sympathetic Dystrophy	8.7%
151	Botulism	8.7%
152	Miller Fisher Syndrome	8.6%
153	Platybasia	8.6%
154	Cartilage Diseases	8.5%
155	Foot Diseases	8.5%
156	Rheumatism	8.5%
157	Chondromalacia	8.5%
158	Polycythemia Vera	8.5%
159	Gout	8.4%
160	Acrodynia	8.3%
161	Lambert-Eaton Myasthenic Syndrome	8.2%
162	Cubital Tunnel Syndrome	8.2%
163	Multiple System Atrophy	8.2%
164	Myasthenic Syndromes, Congenital	8.2%
165	Ankylosing spondylitis	8.1%
166	Diabetic Neuropathies	8.1%
167	Periarthritis	8.1%
168	Diabetic Amyotrophy	8.1%
169	Diabetic Autonomic Neuropathy	8.1%
170	Neuralgia	8%
171	Neuropathic pain	8%
172	Lymphatic Diseases	8%
173	Hemoglobinuria, Paroxysmal	7.9%
174	Pectus excavatum	7.9%
175	Rheumatic Fever	7.9%
176	Chronic granulomatous disease	7.8%
177	Talipes	7.8%
178	Anemia, Hemolytic	7.6%
179	Anemia, Macrocytic	7.6%
180	Hypoproteinemia	7.6%
181	Thrombocytopenia	7.6%
182	MYELODYSPLASTIC SYNDROME	7.6%
183	Sciatic Neuropathy	7.5%
184	Ulnar Neuropathies	7.5%
185	Lesion of Sciatic Nerve	7.5%
186	Ulnar Neuritis	7.5%
187	Radial nerve compression	7.5%
188	Radial Tunnel Syndrome	7.5%
189	Peroneal Neuropathies	7.5%
190	Radial Neuropathy	7.5%
191	Median Neuropathy	7.5%
192	Sciatic Nerve Palsy	7.5%
193	Femoral Neuropathy	7.5%
194	Tibial Neuropathy	7.5%
195	Ulnar Nerve Palsy	7.5%
196	Radial nerve palsy	7.5%
197	Osteoarthritis, Knee	7.3%
198	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7.3%
199	Klippel-Feil Syndrome	7.3%
200	Synostosis	7.3%
201	Trauma, Nervous System	7.3%
202	Febrile Neutropenia	7.2%
203	Restless Legs Syndrome	7.2%
204	POEMS Syndrome	7.1%
205	Ocular Motility Disorders	7.1%
206	Cyclophoria	7.1%
207	Nervous System Neoplasms	7.1%
208	Neurologic Manifestations	7.1%
209	Neurotoxicity Syndromes	7.1%
210	Acrocephalosyndactylia	7.1%
211	Anemia, Diamond-Blackfan	7%
212	Purpura, Thrombotic Thrombocytopenic	7%
213	Hand-Arm Vibration Syndrome	7%
214	Arthritis, Psoriatic	6.9%
215	Arthritis	6.8%
216	Bone Diseases, Developmental	6.8%
217	Bursitis	6.8%
218	Hyperostosis	6.8%
219	Joint Instability	6.8%
220	Osteitis	6.8%
221	Osteitis Deformans	6.8%
222	Osteochondrosis	6.8%
223	Spinal Diseases	6.8%
224	Synovitis	6.8%
225	Joint laxity	6.8%
226	Polyarthritis	6.8%
227	Frozen shoulder	6.8%
228	Patellofemoral Pain Syndrome	6.8%
229	Rheumatoid Arthritis	6.8%
230	Juvenile arthritis	6.8%
231	Craniosynostosis	6.8%
232	Syndactyly	6.8%
233	Brachycephaly	6.8%
234	Encephalomyelitis	6.8%
235	Prion Diseases	6.8%
236	Autonomic Dysreflexia	6.8%
237	Agammaglobulinemia	6.8%
238	Subacute Combined Degeneration	6.8%
239	Ophthalmoplegic Migraine	6.7%
240	Gigantism	6.7%
241	Spinal Neoplasms	6.7%
242	Spondylitis	6.7%
243	Congenital clubfoot	6.6%
244	Vertical Talus	6.6%
245	Meningoencephalitis	6.6%
246	Arthritis, Gouty	6.6%
247	Arthritis, Reactive	6.4%
248	Anemia, Sickle Cell	6.4%
249	Thalassemia	6.4%
250	Parkinson Disease	6.4%
251	Spondylarthropathies	6.3%
252	Myasthenia Gravis, Autoimmune, Experimental	6.2%
253	Polyradiculopathy	6.2%
254	Neuritis, Autoimmune, Experimental	6.1%
255	Anemia, Neonatal	6.1%
256	Paraproteinemias	6.1%
257	Thoracic Outlet Syndrome	6.1%
258	Marchiafava-Bignami Disease	6.1%
259	Craniofacial Dysostosis	6.1%
260	Rheumatoid Nodule	6.1%
261	Lewy Body Disease	6%
262	Sleep Wake Disorders	6%
263	Charcot-Marie-Tooth Disease	6%
264	Striatonigral Degeneration	5.9%
265	Spinal Cord Injuries	5.8%
266	Poland Syndrome	5.8%
267	neurofibroma	5.8%
268	Dandy-Walker Syndrome	5.7%
269	Autoimmune thrombocytopenia	5.7%
270	Immune thrombocytopenic purpura	5.7%
271	Pneumocephalus	5.7%
272	Cryoglobulinemia	5.7%
273	Monoclonal Gammopathy of Undetermined Significance	5.7%
274	Bone Diseases, Endocrine	5.7%
275	Asterixis	5.6%
276	Ballismus	5.6%
277	Progressive supranuclear palsy	5.6%
278	Leukoencephalitis, Acute Hemorrhagic	5.6%
279	Waldenstrom Macroglobulinemia	5.5%
280	Bone Diseases, Infectious	5.5%
281	Bone neoplasms	5.5%
282	Maxillary Diseases	5.5%
283	Osteopenia	5.5%
284	Discitis	5.5%
285	Bone Resorption	5.4%
286	Hemarthrosis	5.4%
287	Tietze's Syndrome	5.4%
288	Limb Deformities, Congenital	5.4%
289	Craniofacial Abnormalities	5.4%
290	Aseptic Necrosis of Bone	5.4%
291	Myelitis, Transverse	5.4%
292	Myelitis	5.4%
293	Waterhouse-Friderichsen Syndrome	5.4%
294	Felty Syndrome	5.2%
295	Epidural Abscess	5.2%
296	Olfactory Nerve Injuries	5.2%
297	Shy-Drager Syndrome	5.2%
298	Hypergammaglobulinemia	5.1%
299	Brain Diseases	5.1%
300	Dysautonomia	5.1%
301	Meningitis	5.1%
302	Movement Disorders	5.1%
303	Pachymeningitis	5.1%
304	Spinal Cord Diseases	5.1%
305	Vagus Nerve Disorder	5.1%
306	Glossopharyngeal Neuralgia	5.1%
307	Abducens Nerve Diseases	5.1%
308	Heavy Metal Poisoning, Nervous System	5.1%
309	Tauopathies	5.1%
310	Trochlear Nerve Diseases	5.1%
311	MPTP Poisoning	5.1%
312	Neuromyelitis Optica	5.1%
313	Neuroleptic Malignant Syndrome	5.1%
314	Myelinolysis, Central Pontine	5.1%
315	Transfusion-Related Acute Lung Injury	5.1%
316	Ainhum	5%
317	Bunion	5%
318	Dysostoses	5%
319	Spinal Stenosis	5%
320	Spondylosis	5%
321	Intervertebral Disc Degeneration	5%
322	Sacroiliitis	5%
323	Ecchymosis	5%
324	Petechiae	5%
325	Purpura	5%
326	Opsoclonus-Myoclonus Syndrome	5%
327	Primary Myelofibrosis	5%
328	Anemia, Megaloblastic	5%
329	Heavy Chain Disease	5%
330	Myelofibrosis	5%
331	Myeloid Metaplasia	5%
332	Hypoalbuminemia	5%
333	bone marrow fibrosis	5%
334	Thrombotic Microangiopathies	5%
335	Sleep Disorders, Circadian Rhythm	5%
336	Encephalomyelitis, Acute Disseminated	5%
337	Purpura, Hyperglobulinemic	4.9%
338	Prognathism	4.9%
339	Hemolytic-Uremic Syndrome	4.9%
340	Dyskinesia, Drug-Induced	4.9%
341	Jaw Abnormalities	4.8%
342	Central Nervous System Cysts	4.8%
343	Goldenhar Syndrome	4.8%
344	Dystonia Musculorum Deformans	4.7%
345	Tuberculosis, Spinal	4.7%
346	Subdural Effusion	4.7%
347	Parkinsonian Disorders	4.7%
348	Nocturnal Myoclonus Syndrome	4.7%
349	Rubinstein-Taybi Syndrome	4.6%
350	Congenital Hypothyroidism	4.6%
351	Acromegaly	4.6%
352	Facial Nerve Injuries	4.6%
353	Sickle Cell Trait	4.6%
354	Rheumatoid Vasculitis	4.5%
355	Leukoencephalopathy, Progressive Multifocal	4.5%
356	Gastroschisis	4.5%
357	Hydrops Fetalis	4.5%
358	Kernicterus	4.5%
359	Brain Injuries	4.5%
360	Mandibulofacial Dysostosis	4.5%
361	Brain Neoplasms	4.4%
362	Multiple Sclerosis	4.4%
363	Spinal Cord Neoplasms	4.4%
364	Multiple Myeloma	4.4%
365	Thrombocytopenic purpura	4.4%
366	Antley-Bixler Syndrome Phenotype	4.3%
367	Horner Syndrome	4.3%
368	Adenitis	4.3%
369	Histiocytosis	4.3%
370	Lymphadenitis	4.3%
371	Lymphangitis	4.3%
372	Lymphedema	4.3%
373	Splenic Diseases	4.3%
374	Thymus Hyperplasia	4.3%
375	Pseudolymphoma	4.3%
376	Lymphadenopathy	4.3%
377	Amyloid Neuropathies, Familial	4.3%
378	Central Nervous System Infection	4.3%
379	Optic Neuropathy	4.3%
380	Fanconi Anemia	4.2%
381	Microcephaly	4.2%
382	Macrocephaly	4.2%
383	Akathisia, Drug-Induced	4.2%
384	Epilepsy, Post-Traumatic	4.2%
385	Chondrodysplasia Punctata	4.2%
386	Enchondromatosis	4.2%
387	Lordosis	4.2%
388	Osteosclerosis	4.2%
389	Spondylolysis	4.2%
390	kyphosis	4.2%
391	Kashin-Beck Disease	4.2%
392	Facial Nerve Diseases	4.1%
393	Craniocerebral Trauma	4.1%
394	Parasomnia	4.1%
395	Dyssomnias	4.1%
396	Huntington Disease	4.1%
397	Limbic Encephalitis	4.1%
398	Lupus Vasculitis, Central Nervous System	4.1%
399	Vestibulocochlear Nerve Diseases	4.1%
400	Arthritis, Infectious	4.1%
401	Decerebrate State	4.1%
402	Hemiparesis	4.1%
403	Hydranencephaly	4.1%
404	Meningism	4.1%
405	Multiple Epiphyseal Dysplasia	4.1%
406	Neural Tube Defects	4.1%
407	Osteochondrodysplasias	4.1%
408	Paresis	4.1%
409	Seizures	4.1%
410	Sensation Disorders	4.1%
411	Tethered Cord Syndrome	4.1%
412	Central Nervous System Neoplasms	4.1%
413	Complex partial seizures	4.1%
414	Iniencephaly	4.1%
415	Craniorachischisis	4.1%
416	Exencephaly	4.1%
417	Monoparesis	4.1%
418	Septo-Optic Dysplasia	4.1%
419	Cortical Dysplasia	4.1%
420	Neurogenic Inflammation	4.1%
421	Gait Disorders, Neurologic	4.1%
422	Neuromuscular Manifestations	4.1%
423	Malformations of Cortical Development	4.1%
424	Sweating, Gustatory	4.1%
425	Auriculotemporal Syndrome	4.1%
426	Sicca Syndrome	4%
427	Sjogren's Syndrome	4%
428	Osteomyelitis	4%
429	Osteoporosis	4%
430	Periostitis	4%
431	Bone Demineralization, Pathologic	4%
432	Post-Traumatic Osteoporosis	4%
433	Arthritis, Experimental	4%
434	Alveolar Bone Loss	4%
435	Amelia	4%
436	Arachnodactyly	4%
437	Ectromelia	4%
438	Femur Head Necrosis	4%
439	Hemimelia	4%
440	Phocomelia	4%
441	Sirenomelia	4%
442	Polydactyly	4%
443	Brachydactyly	4%
444	Plagiocephaly	4%
445	Lower Extremity Deformities, Congenital	4%
446	Upper Extremity Deformities, Congenital	4%
447	Osteolysis	4%
448	Leukemia, Myelomonocytic, Chronic	4%
449	Meige Syndrome	4%
450	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4%
451	Cerebral Ventriculitis	4%
452	Alstrom Syndrome	4%
453	Refsum Disease	4%
454	Scrapie	3.9%
455	Central Cord Syndrome	3.9%
456	Nail-Patella Syndrome	3.9%
457	Presenile dementia	3.9%
458	Senile dementia	3.9%
459	Meningitis, Bacterial	3.9%
460	Meningitis, Fungal	3.9%
461	Giant Cell Epulis	3.9%
462	Lafora Disease	3.9%
463	Unverricht-Lundborg Syndrome	3.9%
464	Chorea	3.9%
465	Brain Abscess	3.8%
466	Ophthalmoplegia	3.8%
467	Palatal Neoplasms	3.8%
468	External Ophthalmoplegia	3.8%
469	Atypical Hemolytic Uremic Syndrome	3.8%
470	Micrognathism	3.8%
471	Pierre Robin Syndrome	3.8%
472	Arthralgia	3.8%
473	Polyarthralgia	3.8%
474	Canavan Disease	3.8%
475	Alexander Disease	3.8%
476	Vasculitis, Central Nervous System	3.8%
477	Jet Lag Syndrome	3.8%
478	Neurofibrosarcoma	3.7%
479	Porencephaly	3.7%
480	Melorheostosis	3.7%
481	Osteopetrosis	3.7%
482	Spondylolisthesis	3.7%
483	Cerebellar Neoplasms	3.7%
484	Tuberous Sclerosis	3.7%
485	Dementia, Vascular	3.7%
486	Brain Hemorrhage, Traumatic	3.7%
487	Posterior Leukoencephalopathy Syndrome	3.6%
488	Posterior reversible encephalopathy syndrome	3.6%
489	Acute Chest Syndrome	3.6%
490	Ataxia Telangiectasia	3.5%
491	Dwarfism	3.5%
492	Pupil Disorders	3.5%
493	Neurobehavioral Manifestations	3.5%
494	Friedreich Ataxia	3.5%
495	Brain Death	3.5%
496	Coma, Post-Head Injury	3.5%
497	Lymphocele	3.4%
498	Lymphoproliferative Disorders	3.4%
499	Lymphatic Abnormalities	3.4%
500	Retrognathia	3.4%
501	Laryngomalacia	3.4%
502	Hip Dislocation	3.4%
503	Shoulder Dislocation	3.4%
504	Paraneoplastic Encephalomyelitis	3.4%
505	Hip Dysplasia	3.4%
506	Thymus Neoplasms	3.4%
507	Uveomeningoencephalitic Syndrome	3.4%
508	Vocal Cord Paralysis	3.4%
509	Sturge-Weber Syndrome	3.4%
510	Vertigo	3.4%
511	Alcohol-Induced Disorders, Nervous System	3.4%
512	Akinetic Mutism	3.4%
513	Anoxic Encephalopathy	3.4%
514	Arachnoiditis	3.4%
515	Basal Ganglia Diseases	3.4%
516	Brain Damage, Chronic	3.4%
517	Cerebellar Diseases	3.4%
518	Encephalitis	3.4%
519	Encephalomalacia	3.4%
520	Epilepsy	3.4%
521	Hydrocephalus	3.4%
522	Congenital Hydrocephalus	3.4%
523	Hypothalamic Diseases	3.4%
524	Aseptic Meningitis	3.4%
525	Syringomyelia	3.4%
526	Thalamic Diseases	3.4%
527	Intracranial Hypertension	3.4%
528	Aura	3.4%
529	Leukoencephalopathy	3.4%
530	Essential Tremor	3.4%
531	Neuroaxonal Dystrophies	3.4%
532	Familial Tremor	3.4%
533	Headache Disorders	3.4%
534	Intracranial Hypotension	3.4%
535	Brain Edema	3.4%
536	Brain Hypoxia	3.4%
537	Aqueductal Stenosis	3.4%
538	Pneumorrhachis	3.4%
539	Writer's Cramp	3.4%
540	Lymphangiectasis, Intestinal	3.4%
541	Amblyopia	3.3%
542	Cockayne Syndrome	3.3%
543	Shwartzman Phenomenon	3.3%
544	Holoprosencephaly	3.3%
545	Joint Tuberculosis	3.3%
546	Tuberculosis, Osteoarticular	3.3%
547	Bone Tuberculosis	3.3%
548	Paraneoplastic Cerebellar Degeneration	3.3%
549	Hemangioma, Cavernous	3.3%
550	Creutzfeldt-Jakob disease	3.3%
551	Basal Ganglia Cerebrovascular Disease	3.3%
552	Osteoporosis, Postmenopausal	3.3%
553	Cerebrospinal Fluid Otorrhea	3.3%
554	Cerebrospinal Fluid Rhinorrhea	3.3%
555	Scurvy	3.3%
556	Purpura Fulminans	3.3%
557	Brain Injuries, Diffuse	3.3%
558	Traumatic Brain Injury	3.3%
559	Gait Ataxia	3.3%
560	Myoclonic Epilepsy	3.3%
561	Epilepsy, Temporal Lobe	3.3%
562	Epilepsy, Rolandic	3.3%
563	Benign Rolandic Epilepsy	3.3%
564	Cerebellar Ataxia	3.3%
565	Supratentorial Neoplasms	3.3%
566	Torticollis	3.3%
567	Multiple Sclerosis, Chronic Progressive	3.3%
568	Multiple Sclerosis, Relapsing-Remitting	3.3%
569	Carotid Artery Injuries	3.3%
570	Tuberculosis, Meningeal	3.3%
571	Hepatolenticular Degeneration	3.2%
572	Vascular Headaches	3%
573	Basal Cell Nevus Syndrome	3%
574	Hypoxia-Ischemia, Brain	3%
575	Tardive Dyskinesia	3%
576	Persistent Vegetative State	3%
577	Alice in Wonderland Syndrome	3%
578	Leukemia, Myeloid, Chronic-Phase	3%
579	Voice Disorders	3%
580	Voice Disturbance	3%
581	Anemia, Pernicious	3%
582	Juvenile Myoclonic Epilepsy	3%
583	Myoclonic Epilepsies, Progressive	3%
584	Alcohol Withdrawal Seizures	2.9%
585	Brain Concussion	2.9%
586	Smith-Magenis syndrome	2.9%
587	Akathisia	2.9%
588	Restlessness	2.9%
589	Psychomotor Agitation	2.9%
590	Maxillofacial Abnormalities	2.9%
591	Dural Arteriovenous Fistula	2.9%
592	Cleft Palate	2.9%
593	Optic Nerve Glioma	2.9%
594	Pituitary Adenoma	2.8%
595	Pituitary Neoplasms	2.8%
596	Rickets	2.8%
597	Leukomalacia, Periventricular	2.8%
598	Bronchomalacia	2.8%
599	Tracheomalacia	2.8%
600	Mucocutaneous Lymph Node Syndrome	2.8%
601	Shoulder Pain	2.8%
602	Osteogenesis Imperfecta	2.8%
603	Toxoplasmosis, Cerebral	2.8%
604	Mastoiditis	2.7%
605	Petrositis	2.7%
606	Diffuse Axonal Injury	2.7%
607	Brain Diseases, Metabolic	2.7%
608	Cerebrovascular Disorders	2.7%
609	Optic Atrophy	2.7%
610	Optic Neuritis	2.7%
611	Papilledema	2.7%
612	Strabismus	2.7%
613	Tolosa-Hunt Syndrome	2.7%
614	Cerebrovascular Insufficiency	2.7%
615	Arsenic Poisoning	2.7%
616	Dementia	2.7%
617	Brain Stem Neoplasms	2.7%
618	Central Nervous System Fungal Infections	2.7%
619	Conus Medullaris Syndrome	2.7%
620	Spinal Cord Vascular Diseases	2.7%
621	Facial Injuries	2.7%
622	Facial Neuralgia	2.7%
623	Sleep Talking	2.7%
624	Manganese Poisoning	2.7%
625	Sleep Disorders, Intrinsic	2.7%
626	Orthostatic intolerance	2.7%
627	Vertebral Artery Dissection	2.7%
628	Amnesia, Transient Global	2.7%
629	Anosmia	2.7%
630	Ataxia	2.7%
631	Athetosis	2.7%
632	Catalepsy	2.7%
633	Dystonia	2.7%
634	Hemiplegia	2.7%
635	Locked-In Syndrome	2.7%
636	Meningeal Neoplasms	2.7%
637	Meningomyelocele	2.7%
638	Muscle Hypertonia	2.7%
639	Muscle hypotonia	2.7%
640	Myoclonus	2.7%
641	Myotonia	2.7%
642	Paraplegia	2.7%
643	Pseudobulbar Palsy	2.7%
644	Quadriplegia	2.7%
645	Spasm	2.7%
646	Spastic Paraplegia	2.7%
647	Status Epilepticus	2.7%
648	Taste Disorders	2.7%
649	Tremor	2.7%
650	Spina Bifida	2.7%
651	Monoplegia	2.7%
652	Hypokinesia	2.7%
653	Paraparesis	2.7%
654	Bradykinesia	2.7%
655	Waxy flexibility	2.7%
656	Action Tremor	2.7%
657	Resting Tremor	2.7%
658	Dysosmia	2.7%
659	Quadriparesis	2.7%
660	Mercury Poisoning, Nervous System	2.7%
661	Olfaction Disorders	2.7%
662	Myokymia	2.7%
663	Lead Poisoning, Nervous System	2.7%
664	Vestibular Neuronitis	2.7%
665	Somatosensory Disorders	2.7%
666	Hyperkinesia	2.7%
667	Intention tremor	2.7%
668	Gait Apraxia	2.7%
669	Basal Ganglia Hemorrhage	2.6%
670	Meningitis, Cryptococcal	2.6%
671	Meningitis, Listeria	2.6%
672	Meningitis, Haemophilus	2.6%
673	Meningitis, Pneumococcal	2.6%
674	Frontotemporal dementia	2.6%
675	Elephantiasis	2.5%
676	Hypersplenism	2.5%
677	Sarcoidosis	2.5%
678	Elephantiasis Nostras Verrucosa	2.5%
679	Cerebral Palsy	2.5%
680	Epilepsies, Partial	2.5%
681	Epilepsy, Generalized	2.5%
682	Pseudotumor Cerebri	2.5%
683	Reflex, Abnormal	2.5%
684	Hypertensive Encephalopathy	2.5%
685	Hyporeflexia	2.5%
686	Hyperreflexia	2.5%
687	Simple Partial Seizures	2.5%
688	Epilepsy, Reflex	2.5%
689	Postural Orthostatic Tachycardia Syndrome	2.5%
690	Headache Disorders, Primary	2.5%
691	Headache Disorders, Secondary	2.5%
692	Medication overuse headache	2.5%
693	Pseudohypoparathyroidism	2.5%
694	Choroid Plexus Papilloma	2.4%
695	Subarachnoid Hemorrhage, Traumatic	2.4%
696	Carotid Artery, Internal, Dissection	2.4%
697	Subacute Sclerosing Panencephalitis	2.4%
698	Putaminal Hemorrhage	2.4%
699	Pituitary Apoplexy	2.4%
700	Adrenoleukodystrophy	2.3%
701	Brain Contusion	2.3%
702	Osteomalacia	2.3%
703	Brain Infarction	2.3%
704	Infarction, Middle Cerebral Artery	2.3%
705	Infarction, Anterior Cerebral Artery	2.3%
706	Infarction, Posterior Cerebral Artery	2.3%
707	Vision Disorders	2.3%
708	Metamorphopsia	2.3%
709	Visual Impairment	2.3%
710	Optic Neuropathy, Ischemic	2.3%
711	Anterior Ischemic Optic Neuropathy	2.3%
712	Central Nervous System Bacterial Infections	2.3%
713	Facial Hemiatrophy	2.3%
714	Melkersson-Rosenthal Syndrome	2.3%
715	Anisocoria	2.2%
716	Confusion	2.2%
717	Facial paralysis	2.2%
718	Lethargy	2.2%
719	Memory Disorders	2.2%
720	Perceptual Disorders	2.2%
721	Psychomotor Disorders	2.2%
722	Tonic Pupil	2.2%
723	Anhedonia	2.2%
724	Disorientation	2.2%
725	Facial Paresis	2.2%
726	Memory Loss	2.2%
727	Hemisensory Neglect	2.2%
728	Dysacusis	2.2%
729	Classical Lissencephalies and Subcortical Band Heterotopias	2.2%
730	Sleep Bruxism	2.2%
731	Noonan Syndrome	2.2%
732	Anencephaly	2.2%
733	Meningocele	2.2%
734	Muscular Atrophy	2.2%
735	Respiratory Paralysis	2.2%
736	Encephalocele	2.2%
737	Tetany	2.2%
738	Auditory Perceptual Disorders	2.2%
739	Acoustic Neuroma	2.2%
740	Giant Cell Arteritis	2.1%
741	Temporal Arteritis	2.1%
742	Cerebral Infarction	2.1%
743	Brain Stem Infarctions	2.1%
744	Pituitary Diseases	2.1%
745	Post-Traumatic Headache	2.1%
746	Tension Headache	2.1%
747	Epilepsy, Complex Partial	2.1%
748	Migraine Disorders	2.1%
749	Abdominal Migraine	2.1%
750	Status Migrainosus	2.1%
751	Cervicogenic Headache	2.1%
752	Granuloma	2%
753	Histiocytic Disorders, Malignant	2%
754	Splenic Infarction	2%
755	Splenic Neoplasms	2%
756	Alexia	2%
757	Dyslexia	2%
758	Marfan Syndrome	2%
759	Histiocytosis, Langerhans-Cell	2%
760	Pseudoxanthoma Elasticum	2%
761	Tumor Lysis Syndrome	2%
762	Carotid Artery Diseases	2%
763	Brain Ischemia	2%
764	Esotropia	2%
765	Exotropia	2%
766	Hypotension, Orthostatic	2%
767	Sleep Apnea Syndromes	2%
768	Cerebrovascular accident	2%
769	Kluver-Bucy Syndrome	2%
770	Vasospasm, Intracranial	2%
771	Spinal Cord Ischemia	2%
772	Intracranial Arterial Diseases	2%
773	Post-Exercise Hypotension	2%
774	Disorders of Excessive Somnolence	2%
775	Sleep Initiation and Maintenance Disorders	2%
776	Night Terrors	2%
777	Somnambulism	2%
778	Trigeminal Nerve Disorder	2%
779	Transient Insomnia	2%
780	Sleep Paralysis	2%
781	Chronic Insomnia	2%
782	REM Sleep Behavior Disorder	2%
783	Hypersomnia	2%
784	Dermal Sinus	2%
785	Dysgeusia	2%
786	Formication	2%
787	Hyperalgesia	2%
788	Hyperesthesia	2%
789	Hypesthesia	2%
790	Language Disorders	2%
791	Numbness	2%
792	Paresthesia	2%
793	Paraparesis, Spastic	2%
794	Spina Bifida Cystica	2%
795	Trismus	2%
796	Spina Bifida Occulta	2%
797	Epilepsia Partialis Continua	2%
798	Hypogeusia	2%
799	Meningeal Carcinomatosis	2%
800	Brown-Sequard Syndrome	2%
801	Lissencephaly	2%
802	Polymicrogyria	2%
803	Pachygyria	2%
804	Schizencephaly	2%
805	Lockjaw	2%
806	Allodynia	2%
807	Lead Poisoning, Nervous System, Childhood	2%
808	Lead Poisoning, Nervous System, Adult	2%
809	Periventricular Nodular Heterotopia	2%
810	Ageusia	2%
811	Tuberculosis, Central Nervous System	2%
812	West Nile Fever	2%
813	Lateral Medullary Syndrome	2%
814	Duane Retraction Syndrome	2%
815	Consciousness Disorders	1.9%
816	Mental Retardation	1.9%
817	Depressed Level of Consciousness	1.9%
818	Mental deficiency	1.9%
819	Intellectual Disability	1.9%
820	Moyamoya Disease	1.9%
821	Mobius Syndrome	1.9%
822	Bell Palsy	1.9%
823	Catatonia	1.9%
824	Herpes Zoster Oticus	1.9%
825	Aphonia	1.9%
826	Sleep Deprivation	1.9%
827	Dysphonia	1.9%
828	Hematoma, Subdural	1.9%
829	Hematoma, Epidural, Cranial	1.9%
830	Cluster Headache	1.9%
831	Migraine with Aura	1.9%
832	Familial Hemiplegic Migraine	1.9%
833	Chronic Paroxysmal Hemicrania	1.9%
834	SUNCT Syndrome	1.9%
835	Paroxysmal Hemicrania	1.9%
836	Radicular Cyst	1.8%
837	Optic Atrophy, Hereditary, Leber	1.8%
838	Eye Injuries	1.7%
839	Splenic Rupture	1.7%
840	Nose Neoplasms	1.7%
841	Lymphoma	1.7%
842	Sezary Syndrome	1.7%
843	Congenital nystagmus	1.7%
844	Empty Sella Syndrome	1.7%
845	Hyperpituitarism	1.7%
846	Hypopituitarism	1.7%
847	Hypophysitis	1.7%
848	Diplopia	1.7%
849	Scotoma	1.7%
850	Photophobia	1.7%
851	Hemifacial Spasm	1.7%
852	Amaurosis	1.7%
853	Blindness	1.7%
854	Lymphohistiocytosis, Hemophagocytic	1.7%
855	Reye Syndrome	1.7%
856	Thymoma	1.7%
857	Neuroaspergillosis	1.7%
858	Erdheim-Chester Disease	1.7%
859	Hematoma, Subdural, Intracranial	1.7%
860	Hematoma, Subdural, Chronic	1.7%
861	Hematoma, Subdural, Acute	1.7%
862	Intracranial Embolism and Thrombosis	1.7%
863	Hepatic Encephalopathy	1.7%
864	Agnosia	1.7%
865	Apraxias	1.7%
866	Hallucinations	1.7%
867	Hemianopsia	1.7%
868	Hyperacusis	1.7%
869	Tinnitus	1.7%
870	Visual Agnosia	1.7%
871	Anosognosia	1.7%
872	Wernicke-Korsakoff Syndrome	1.7%
873	Phonophobia	1.7%
874	Hearing Loss	1.7%
875	Cerebral Arterial Diseases	1.7%
876	Vertebrobasilar Insufficiency	1.7%
877	Anterior Spinal Artery Syndrome	1.7%
878	Basilar Artery Stenosis	1.7%
879	Vertebral Artery Stenosis	1.7%
880	Sleep Apnea, Obstructive	1.7%
881	Sleep Apnea, Central	1.7%
882	Intracranial Hemorrhage, Hypertensive	1.7%
883	Transient Cerebral Ischemia	1.7%
884	Neuronal Ceroid-Lipofuscinoses	1.6%
885	Narcolepsy	1.6%
886	Trigeminal Neuralgia	1.6%
887	Kleine-Levin Syndrome	1.6%
888	Sarcopenia	1.6%
889	Agraphia	1.6%
890	Anomia	1.6%
891	Cluttering	1.6%
892	Language Development Disorders	1.6%
893	Speech Disorders	1.6%
894	Syncope	1.6%
895	Stupor	1.6%
896	Dysgraphia	1.6%
897	Presyncope	1.6%
898	Dyslalia	1.6%
899	Renal Osteodystrophy	1.6%
900	Renal rickets	1.6%
901	Aicardi's syndrome	1.5%
902	Hoarseness	1.5%
903	Hyperprolactinemia	1.5%
904	Pseudorabies	1.5%
905	Subclavian Steal Syndrome	1.5%
906	Pick Disease of the Brain	1.5%
907	Cataplexy	1.5%
908	Aphasia	1.5%
909	Articulation Disorders	1.5%
910	Echolalia	1.5%
911	Stuttering	1.5%
912	Dysphasia	1.5%
913	Alcohol Withdrawal Delirium	1.5%
914	Autoimmune Lymphoproliferative Syndrome	1.5%
915	Amnesia	1.4%
916	Delirium	1.4%
917	Dissociative Amnesia	1.4%
918	Color blindness	1.4%
919	Global Amnesia	1.4%
920	Cri-du-Chat Syndrome	1.4%
921	Down Syndrome	1.4%
922	Brain Diseases, Metabolic, Inborn	1.4%
923	Trisomy 21	1.4%
924	Meningioma	1.4%
925	Williams Syndrome	1.4%
926	Neurosyphilis	1.4%
927	Toxoplasmosis, Congenital	1.4%
928	Dysarthria	1.4%
929	Eye Burns	1.4%
930	Malaria, Cerebral	1.4%
931	Carotid Stenosis	1.4%
932	Intracranial Aneurysm	1.4%
933	Neurocysticercosis	1.4%
934	Amaurosis Fugax	1.4%
935	Blindness, Cortical	1.4%
936	Dyscalculia	1.4%
937	Intracranial Arteriosclerosis	1.4%
938	Cerebral Atherosclerosis	1.4%
939	Rett Syndrome	1.4%
940	Subarachnoid Hemorrhage	1.4%
941	Cerebral Arteriosclerosis	1.4%
942	Cerebral Hemorrhage	1.4%
943	Cerebral Thrombosis	1.4%
944	Intracranial Embolism	1.4%
945	Intracranial Thrombosis	1.4%
946	Deafness	1.4%
947	Hearing Loss, Sudden	1.4%
948	Gerstmann Syndrome	1.4%
949	Hearing Loss, Bilateral	1.4%
950	Hearing Loss, High-Frequency	1.4%
951	Hearing Loss, Mixed Conductive-Sensorineural	1.4%
952	Prosopagnosia	1.4%
953	Apraxia, Ideomotor	1.4%
954	Charles Bonnet Syndrome	1.4%
955	Hearing Loss, Unilateral	1.4%
956	Complete Hearing Loss	1.4%
957	Alien Hand Syndrome	1.4%
958	Deaf Mutism	1.4%
959	Malignant histiocytosis	1.3%
960	Sarcoidosis, Pulmonary	1.3%
961	Histiocytic sarcoma	1.3%
962	Menkes Kinky Hair Syndrome	1.3%
963	Mutism	1.2%
964	Selective Mutism	1.2%
965	Prader-Willi Syndrome	1.2%
966	Wernicke Encephalopathy	1.2%
967	AIDS Dementia Complex	1.2%
968	Phantom pain	1.2%
969	Phantom Limb Pain	1.2%
970	Cerebral Amyloid Angiopathy	1.2%
971	Lyme Neuroborreliosis	1.2%
972	Sinus Thrombosis, Intracranial	1.2%
973	Corneal Scar	1.2%
974	Retrograde amnesia	1.2%
975	Amnesia, Anterograde	1.2%
976	Carotid Artery Thrombosis	1.2%
977	Alexia, Pure	1.2%
978	Cavernous Sinus Thrombosis	1.2%
979	Sagittal Sinus Thrombosis	1.2%
980	Splenosis	1.1%
981	Hodgkin Disease	1.1%
982	Lymphoma, Non-Hodgkin	1.1%
983	Leukemia, T-Cell	1.1%
984	Leukemia, B-Cell	1.1%
985	Corneal Perforation	1.1%
986	Fragile X Syndrome	1%
987	Nelson Syndrome	1%
988	Fabry Disease	1%
989	Familial Hypophosphatemic Rickets	1%
990	Composite Lymphoma	0.9%
991	Lymphangioleiomyomatosis	0.9%
992	Prolactinoma	0.9%
993	Growth Hormone-Secreting Pituitary Adenoma	0.9%
994	Galactosemias	0.9%
995	Urea Cycle Disorders, Inborn	0.9%
996	Tyrosinemias	0.9%
997	Niemann-Pick Disease, Type C	0.9%
998	Homocystinuria	0.8%
999	Lymphoma, Follicular	0.8%
1000	T-Cell Lymphoma	0.8%
1001	Mantle cell lymphoma	0.8%
1002	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
1003	Leukemia, Large Granular Lymphocytic	0.8%
1004	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
1005	Leigh Disease	0.8%
1006	Mucopolysaccharidosis II	0.7%
1007	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.7%
1008	Lymphoma, T-Cell, Cutaneous	0.7%
1009	Lymphoma, AIDS-Related	0.7%
1010	Enteropathy-Associated T-Cell Lymphoma	0.7%
1011	Primary Effusion Lymphoma	0.7%
1012	Glycogen storage disease type II	0.7%
1013	Zellweger Syndrome	0.6%
1014	Mycosis Fungoides	0.6%
1015	Lymphomatoid Papulosis	0.6%
1016	Plasmablastic lymphoma	0.6%
1017	Lymphomatoid Granulomatosis	0.6%
1018	Gaucher Disease	0.6%
1019	Tay-Sachs Disease	0.5%
1020	Burkitt Lymphoma	0.5%

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