MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Meningomyelocele

(UMLS:C0025312)

Definition:: Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)
UMLS ID:: C0025312
MeSH ID:: D008591

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.680.610

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.666.680.610

Synonym(s)

Meningomyelocele

MENINGOMYELOCELE

Myelocystocele

Myelomeningocele

Spina Bifida Cystica

Spina bifida cystica

meningomyelocele

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Paroxetine	FAERS: 25		US FAERS
2	Folic Acid	FAERS: 18	25885259	CTD US FAERS
3	Valproic Acid	FAERS: 15	View details 1377411 2499680 3080718 3919914 6401849 7687042 12237071	CTD US FAERS
4	Sertraline	FAERS: 8		US FAERS
5	Carbamazepine	FAERS: 7 Canada Vigilance: 1		Canada Vigilance US FAERS
6	Methotrexate	FAERS: 7		US FAERS
7	Isotretinoin	FAERS: 6		US FAERS
8	Zolpidem	FAERS: 6		US FAERS
9	Clozapine	FAERS: 5		US FAERS
10	Fluoxetine	FAERS: 5		US FAERS
11	Valproic Acid	FAERS: 5		US FAERS
12	Valproic Acid	FAERS: 5		US FAERS
13	Zolpidem	FAERS: 4		US FAERS
14	Topiramate	FAERS: 3		US FAERS
15	Venlafaxine Hydrochloride	FAERS: 3		US FAERS
16	Aripiprazole	FAERS: 2		US FAERS
17	Letrozole	FAERS: 2		US FAERS
18	Tacrolimus	FAERS: 2		US FAERS
19	Warfarin	FAERS: 2		US FAERS
20	Acetaminophen	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
21	Buprenorphine	FAERS: 1		US FAERS
22	Citalopram	FAERS: 1		US FAERS
23	Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	FAERS: 1		US FAERS
24	Glatiramer Acetate	FAERS: 1		US FAERS
25	Lopinavir	FAERS: 1		US FAERS
26	Lovastatin	FAERS: 1		US FAERS
27	Mesalamine	FAERS: 1		US FAERS
28	Metformin	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
29	Methotrexate	FAERS: 1		US FAERS
30	Misoprostol	FAERS: 1		US FAERS
31	NuvaRing	FAERS: 1		US FAERS
32	Pregabalin	FAERS: 1		US FAERS
33	Quetiapine Fumarate	FAERS: 1		US FAERS
34	Risperidone	FAERS: 1		US FAERS
35	Tolterodine Tartrate	FAERS: 1		US FAERS
36	dolutegravir	FAERS: 1		US FAERS
37	efavirenz	FAERS: 1		US FAERS
38	Clomiphene		650331	CTD SIDER
39	Homocysteine		16602021	CTD
40	Lithium Carbonate		5273542	CTD
41	Paroxetine	Canada Vigilance: 2		Canada Vigilance
42	Tretinoin		15893307 16940565	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Spina Bifida	47.5%
2	Anencephaly	44.1%
3	Meningocele	38.2%
4	Encephalocele	38.2%
5	Dermal Sinus	35.2%
6	Spina Bifida Cystica	35.2%
7	Spina Bifida Occulta	35.2%
8	Hydranencephaly	32.8%
9	Septo-Optic Dysplasia	32.8%
10	Cortical Dysplasia	32.8%
11	Malformations of Cortical Development	32.8%
12	Dural Arteriovenous Fistula	25%
13	Dandy-Walker Syndrome	24.9%
14	Central Nervous System Cysts	23.9%
15	Aicardi's syndrome	19.7%
16	Holoprosencephaly	19.4%
17	Classical Lissencephalies and Subcortical Band Heterotopias	17.3%
18	Abnormalities, Drug-Induced	16.9%
19	Situs Inversus	16.9%
20	Lissencephaly	15.8%
21	Polymicrogyria	15.8%
22	Pachygyria	15.8%
23	Schizencephaly	15.8%
24	Periventricular Nodular Heterotopia	15.8%
25	Charcot-Marie-Tooth Disease	15.5%
26	Smith-Magenis syndrome	15.1%
27	Beckwith-Wiedemann Syndrome	13.9%
28	Wolf-Hirschhorn Syndrome	13.9%
29	Microcephaly	13.8%
30	Macrocephaly	13.8%
31	Eye Abnormalities	13.3%
32	Cardiovascular Abnormalities	13.3%
33	Cri-du-Chat Syndrome	13.2%
34	Down Syndrome	13.2%
35	Trisomy 21	13.2%
36	Alstrom Syndrome	13.2%
37	Porencephaly	12.9%
38	Skin Abnormalities	12.8%
39	Lymphatic Abnormalities	12.8%
40	Congenital Microtia	12.8%
41	Congenital diaphragmatic hernia	12.5%
42	Cranial nerve diseases	11.8%
43	Demyelinating Diseases	11.8%
44	Demyelination	11.8%
45	Neuromuscular Diseases	11.8%
46	Chronobiology Disorders	11.8%
47	Prader-Willi Syndrome	11.3%
48	Rubinstein-Taybi Syndrome	10.9%
49	Tuberous Sclerosis	10.9%
50	Urogenital Abnormalities	10.6%
51	Genetic Diseases, Inborn	10.6%
52	Motor Neuron Disease	10.3%
53	Mobius Syndrome	10.1%
54	Ectodermal Dysplasia	10%
55	Aplasia Cutis Congenita	10%
56	Refsum Disease	10%
57	Prune Belly Syndrome	9.9%
58	Twins, Conjoined	9.9%
59	Waardenburg Syndrome	9.9%
60	Multiple System Atrophy	9.4%
61	CHARGE Syndrome	9.4%
62	Trauma, Nervous System	9.2%
63	Stiff-Person Syndrome	9%
64	Nervous System Neoplasms	8.8%
65	Neurologic Manifestations	8.8%
66	Neurotoxicity Syndromes	8.8%
67	Ocular Motility Disorders	8.5%
68	Cyclophoria	8.5%
69	Polyradiculoneuropathy	8.4%
70	Polyradiculoneuritis	8.4%
71	Encephalomyelitis	8.4%
72	Prion Diseases	8.4%
73	Autonomic Dysreflexia	8.4%
74	Complex Regional Pain Syndromes	8.4%
75	Maxillofacial Abnormalities	8.3%
76	Dextrocardia	8.2%
77	Restless Legs Syndrome	8.2%
78	Williams Syndrome	8.2%
79	Fetal Diseases	8%
80	Spinal Muscular Atrophy	7.9%
81	Progressive Muscular Atrophy	7.9%
82	Nail-Patella Syndrome	7.9%
83	Cockayne Syndrome	7.9%
84	Xeroderma	7.8%
85	Subacute Combined Degeneration	7.7%
86	Meningoencephalitis	7.7%
87	Parkinson Disease	7.6%
88	Anophthalmos	7.6%
89	Anus, Imperforate	7.6%
90	Microphthalmos	7.6%
91	Limb Deformities, Congenital	7.6%
92	Craniofacial Abnormalities	7.6%
93	Myasthenic Syndromes, Congenital	7.6%
94	Anorectal Malformations	7.6%
95	Amyotrophic Lateral Sclerosis	7.5%
96	Marchiafava-Bignami Disease	7.5%
97	Marfan Syndrome	7.5%
98	Bloom Syndrome	7.4%
99	Ophthalmoplegic Migraine	7.4%
100	Kartagener Syndrome	7.4%
101	Sleep Wake Disorders	7.2%
102	Dystonia Musculorum Deformans	7.1%
103	Abnormalities, Radiation-Induced	7.1%
104	Spinal Cord Injuries	7%
105	Lewy Body Disease	6.8%
106	Peripheral Nerve Injuries	6.8%
107	Guillain-Barre Syndrome	6.8%
108	Striatonigral Degeneration	6.8%
109	Brain Diseases	6.7%
110	Dysautonomia	6.7%
111	Meningitis	6.7%
112	Movement Disorders	6.7%
113	Pachymeningitis	6.7%
114	Spinal Cord Diseases	6.7%
115	Vagus Nerve Disorder	6.7%
116	Glossopharyngeal Neuralgia	6.7%
117	Abducens Nerve Diseases	6.7%
118	Heavy Metal Poisoning, Nervous System	6.7%
119	Neuromuscular Junction Diseases	6.7%
120	Tauopathies	6.7%
121	Trochlear Nerve Diseases	6.7%
122	Peripheral Nervous System Diseases	6.7%
123	Myasthenia Gravis	6.7%
124	Asterixis	6.7%
125	Ballismus	6.7%
126	Fragile X Syndrome	6.7%
127	Myelitis	6.6%
128	Progressive bulbar palsy	6.6%
129	Bulbar palsy	6.6%
130	Pneumocephalus	6.6%
131	Poliomyelitis	6.6%
132	POEMS Syndrome	6.6%
133	Polycystic Kidney Diseases	6.5%
134	Causalgia	6.5%
135	Scimitar Syndrome	6.4%
136	Progressive supranuclear palsy	6.2%
137	Blepharophimosis	6.1%
138	Laryngostenosis	6.1%
139	Mouth Abnormalities	6.1%
140	Lafora Disease	6.1%
141	Unverricht-Lundborg Syndrome	6.1%
142	Leukoencephalitis, Acute Hemorrhagic	6.1%
143	Esophageal Atresia	6%
144	Intestinal Atresia	6%
145	Horseshoe Kidney	6%
146	Pectus excavatum	6%
147	Epidural Abscess	6%
148	Olfactory Nerve Injuries	6%
149	Klippel-Feil Syndrome	6%
150	Neuroleptic Malignant Syndrome	6%
151	Myelinolysis, Central Pontine	6%
152	Gastroschisis	6%
153	Synostosis	6%
154	Acrodermatitis	6%
155	Lymphangiectasis, Intestinal	6%
156	Gianotti-Crosti Syndrome	6%
157	Miller Fisher Syndrome	6%
158	Myelitis, Transverse	5.9%
159	MPTP Poisoning	5.9%
160	Retinal Dysplasia	5.9%
161	Chronic Fatigue Syndrome	5.8%
162	Lambert-Eaton Myasthenic Syndrome	5.8%
163	Shy-Drager Syndrome	5.8%
164	Aniridia	5.8%
165	Cystic Fibrosis	5.8%
166	Sleep Disorders, Circadian Rhythm	5.8%
167	Ataxia Telangiectasia	5.8%
168	Reflex Sympathetic Dystrophy	5.7%
169	Subdural Effusion	5.7%
170	Parkinsonian Disorders	5.7%
171	Nocturnal Myoclonus Syndrome	5.7%
172	Encephalomyelitis, Acute Disseminated	5.7%
173	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.7%
174	Epidermolysis Bullosa	5.7%
175	Huntington Disease	5.6%
176	Myotonic Dystrophy	5.6%
177	Abdominal Cramps	5.6%
178	Amniotic Band Syndrome	5.6%
179	Asphyxia Neonatorum	5.6%
180	Infant, Premature, Diseases	5.6%
181	Infantile Colic	5.6%
182	Craniosynostosis	5.6%
183	Syndactyly	5.6%
184	Brachycephaly	5.6%
185	Canavan Disease	5.6%
186	Alexander Disease	5.6%
187	Botulism	5.6%
188	Neuromyelitis Optica	5.5%
189	Opsoclonus-Myoclonus Syndrome	5.5%
190	Myotonia Congenita	5.5%
191	Dyskinesia, Drug-Induced	5.4%
192	Muscular Dystrophy	5.3%
193	Congenital nystagmus	5.3%
194	Central Nervous System Infection	5.3%
195	Myopathy	5.3%
196	Optic Neuropathy	5.3%
197	Brain Injuries	5.3%
198	Primary Ciliary Dyskinesia	5.3%
199	Smith-Lemli-Opitz Syndrome	5.3%
200	Brain Neoplasms	5.3%
201	Multiple Sclerosis	5.3%
202	Spinal Cord Neoplasms	5.3%
203	Hepatolenticular Degeneration	5.2%
204	Facial Nerve Injuries	5.2%
205	Arthrogryposis	5.1%
206	Choanal Atresia	5.1%
207	Tracheobronchomegaly	5.1%
208	Laryngocele	5.1%
209	Facial Nerve Diseases	5.1%
210	Craniocerebral Trauma	5.1%
211	Parasomnia	5.1%
212	Dyssomnias	5.1%
213	Choledochal Cyst	5.1%
214	Hermaphroditism	5.1%
215	Disorders of Sex Development	5.1%
216	Ichthyosis, X-Linked	5.1%
217	Vestibulocochlear Nerve Diseases	5%
218	Decerebrate State	5%
219	Hemiparesis	5%
220	Meningism	5%
221	Paresis	5%
222	Seizures	5%
223	Sensation Disorders	5%
224	Central Nervous System Neoplasms	5%
225	Complex partial seizures	5%
226	Monoparesis	5%
227	Neurogenic Inflammation	5%
228	Gait Disorders, Neurologic	5%
229	Neuromuscular Manifestations	5%
230	Cryptorchidism	5%
231	Hypospadias	5%
232	Sweating, Gustatory	5%
233	Auriculotemporal Syndrome	5%
234	Noonan Syndrome	5%
235	Horner Syndrome	5%
236	Toxoplasmosis, Congenital	5%
237	Amelia	4.9%
238	Arachnodactyly	4.9%
239	Ectopia Cordis	4.9%
240	Ectromelia	4.9%
241	Hemimelia	4.9%
242	Leukomalacia, Periventricular	4.9%
243	Phocomelia	4.9%
244	Sirenomelia	4.9%
245	Polydactyly	4.9%
246	Brachydactyly	4.9%
247	Plagiocephaly	4.9%
248	Lower Extremity Deformities, Congenital	4.9%
249	Upper Extremity Deformities, Congenital	4.9%
250	Single umbilical artery	4.9%
251	Leukoencephalopathy, Progressive Multifocal	4.9%
252	Meconium Aspiration Syndrome	4.9%
253	Meige Syndrome	4.9%
254	Brachial Plexus Neuritis	4.9%
255	Neuralgic Amyotrophy	4.9%
256	Cerebral Ventriculitis	4.9%
257	Friedreich Ataxia	4.9%
258	Epilepsy, Post-Traumatic	4.9%
259	Acrocephalosyndactylia	4.8%
260	Akathisia, Drug-Induced	4.8%
261	Limbic Encephalitis	4.7%
262	Scrapie	4.7%
263	Central Cord Syndrome	4.7%
264	Muscular Dystrophy, Duchenne	4.6%
265	Presenile dementia	4.6%
266	Senile dementia	4.6%
267	Meningitis, Bacterial	4.6%
268	Meningitis, Fungal	4.6%
269	Chorea	4.6%
270	Acrodynia	4.6%
271	Turner Syndrome	4.5%
272	Myasthenia Gravis, Autoimmune, Experimental	4.5%
273	Tarsal Tunnel Syndrome	4.5%
274	Cauda Equina Syndrome	4.5%
275	Posterior Leukoencephalopathy Syndrome	4.5%
276	Posterior reversible encephalopathy syndrome	4.5%
277	Brain Abscess	4.4%
278	Ophthalmoplegia	4.4%
279	Pseudoxanthoma Elasticum	4.4%
280	External Ophthalmoplegia	4.4%
281	Neoplastic Syndromes, Hereditary	4.4%
282	Akinetic Mutism	4.4%
283	Anoxic Encephalopathy	4.4%
284	Arachnoiditis	4.4%
285	Basal Ganglia Diseases	4.4%
286	Brain Damage, Chronic	4.4%
287	Cerebellar Diseases	4.4%
288	Encephalitis	4.4%
289	Encephalomalacia	4.4%
290	Epilepsy	4.4%
291	Hydrocephalus	4.4%
292	Congenital Hydrocephalus	4.4%
293	Hypothalamic Diseases	4.4%
294	Aseptic Meningitis	4.4%
295	Neuritis	4.4%
296	Polyneuritis	4.4%
297	Radiculitis	4.4%
298	Syringomyelia	4.4%
299	Thalamic Diseases	4.4%
300	Intracranial Hypertension	4.4%
301	Polyneuropathy	4.4%
302	Mononeuritis	4.4%
303	Aura	4.4%
304	Leukoencephalopathy	4.4%
305	Essential Tremor	4.4%
306	Neuroaxonal Dystrophies	4.4%
307	Familial Tremor	4.4%
308	Headache Disorders	4.4%
309	Mononeuropathies	4.4%
310	Intracranial Hypotension	4.4%
311	Brachial Plexus Neuropathies	4.4%
312	Radiculopathy	4.4%
313	Mononeuropathy Multiplex	4.4%
314	Nerve Root Compression	4.4%
315	Brain Edema	4.4%
316	Brain Hypoxia	4.4%
317	Aqueductal Stenosis	4.4%
318	Pneumorrhachis	4.4%
319	Writer's Cramp	4.4%
320	Laryngomalacia	4.4%
321	Lupus Vasculitis, Central Nervous System	4.4%
322	Jaw Abnormalities	4.4%
323	Pectus carinatum	4.3%
324	Amyloid Neuropathies, Familial	4.3%
325	Polycystic Kidney, Autosomal Dominant	4.3%
326	Bladder Exstrophy	4.3%
327	Epispadias	4.3%
328	Vasculitis, Central Nervous System	4.3%
329	Cerebellar Neoplasms	4.3%
330	Jet Lag Syndrome	4.3%
331	Multicystic Dysplastic Kidney	4.3%
332	Zellweger Syndrome	4.2%
333	Cleft Palate	4.2%
334	Rett Syndrome	4.2%
335	Anemia, Neonatal	4.2%
336	Multiple Epiphyseal Dysplasia	4.2%
337	Osteochondrodysplasias	4.2%
338	Pelger-Huet Anomaly	4.2%
339	Persistent Fetal Circulation Syndrome	4.2%
340	Werner Syndrome	4.2%
341	Pupil Disorders	4.2%
342	Neurobehavioral Manifestations	4.2%
343	Adrenoleukodystrophy	4.2%
344	Umbilical hernia	4.1%
345	Poland Syndrome	4.1%
346	Brain Death	4.1%
347	Coma, Post-Head Injury	4.1%
348	Paraneoplastic Encephalomyelitis	4.1%
349	Dementia, Vascular	4%
350	Myoclonic Epilepsy	4%
351	Epilepsy, Temporal Lobe	4%
352	Epilepsy, Rolandic	4%
353	Benign Rolandic Epilepsy	4%
354	Brain Hemorrhage, Traumatic	4%
355	Uveomeningoencephalitic Syndrome	4%
356	Xeroderma Pigmentosum	4%
357	Sturge-Weber Syndrome	4%
358	Vertigo	4%
359	Alcohol-Induced Disorders, Nervous System	4%
360	Sjogren-Larsson Syndrome	4%
361	Duane Retraction Syndrome	4%
362	Neuronal Ceroid-Lipofuscinoses	4%
363	Aortic coarctation	3.9%
364	Cor Triatriatum	3.9%
365	Coronary Vessel Anomalies	3.9%
366	Dental Enamel Hypoplasia	3.9%
367	Patent ductus arteriosus	3.9%
368	Ebstein Anomaly	3.9%
369	Heart Septal Defects	3.9%
370	Hypodontia	3.9%
371	Macrostomia	3.9%
372	Microstomia	3.9%
373	Tetralogy of Fallot	3.9%
374	Transposition of Great Vessels	3.9%
375	Hypoplastic Left Heart Syndrome	3.9%
376	May-Thurner Syndrome	3.9%
377	Craniofacial Dysostosis	3.9%
378	Creutzfeldt-Jakob disease	3.9%
379	Basal Ganglia Cerebrovascular Disease	3.9%
380	Wolff-Parkinson-White Syndrome	3.9%
381	Brain Injuries, Diffuse	3.9%
382	Traumatic Brain Injury	3.9%
383	Kallmann Syndrome	3.9%
384	Cerebellar Ataxia	3.9%
385	Supratentorial Neoplasms	3.9%
386	Torticollis	3.9%
387	Multiple Sclerosis, Chronic Progressive	3.9%
388	Multiple Sclerosis, Relapsing-Remitting	3.9%
389	Amblyopia	3.9%
390	Vocal Cord Paralysis	3.8%
391	Paraneoplastic Cerebellar Degeneration	3.8%
392	Cerebrospinal Fluid Otorrhea	3.8%
393	Cerebrospinal Fluid Rhinorrhea	3.8%
394	Neuritis, Autoimmune, Experimental	3.8%
395	Gait Ataxia	3.8%
396	Klinefelter Syndrome	3.8%
397	Antley-Bixler Syndrome Phenotype	3.7%
398	Tuberculosis, Meningeal	3.7%
399	Carotid Artery Injuries	3.7%
400	Juvenile Myoclonic Epilepsy	3.6%
401	Myoclonic Epilepsies, Progressive	3.6%
402	Carpal Tunnel Syndrome	3.6%
403	Vascular Headaches	3.6%
404	Welander Distal Myopathy	3.6%
405	Basal Cell Nevus Syndrome	3.6%
406	neurofibroma	3.6%
407	Hypoxia-Ischemia, Brain	3.6%
408	Sciatica	3.5%
409	Tardive Dyskinesia	3.5%
410	Persistent Vegetative State	3.5%
411	Menkes Kinky Hair Syndrome	3.5%
412	Dwarfism	3.5%
413	Neonatal Abstinence Syndrome	3.4%
414	Optic Atrophy, Hereditary, Leber	3.4%
415	Voice Disorders	3.4%
416	Voice Disturbance	3.4%
417	Hyperkeratosis, Epidermolytic	3.4%
418	Brain Diseases, Metabolic	3.4%
419	Cerebrovascular Disorders	3.4%
420	Myositis	3.4%
421	Optic Atrophy	3.4%
422	Optic Neuritis	3.4%
423	Papilledema	3.4%
424	Strabismus	3.4%
425	Tolosa-Hunt Syndrome	3.4%
426	Cerebrovascular Insufficiency	3.4%
427	Isaacs syndrome	3.4%
428	Arsenic Poisoning	3.4%
429	Dementia	3.4%
430	Myotonic Disorders	3.4%
431	Central Nervous System Fungal Infections	3.4%
432	Conus Medullaris Syndrome	3.4%
433	Spinal Cord Vascular Diseases	3.4%
434	Fetal Growth Retardation	3.4%
435	Micrognathism	3.3%
436	Pierre Robin Syndrome	3.3%
437	Osteogenesis Imperfecta	3.3%
438	Fetal Hypoxia	3.3%
439	Fetal Alcohol Spectrum Disorders	3.3%
440	Alice in Wonderland Syndrome	3.3%
441	Familial Periodic Paralysis	3.3%
442	Diabetic Neuropathies	3.3%
443	Facial Injuries	3.3%
444	Facial Neuralgia	3.3%
445	Diabetic Amyotrophy	3.3%
446	Diabetic Autonomic Neuropathy	3.3%
447	Sleep Talking	3.3%
448	Manganese Poisoning	3.3%
449	Sleep Disorders, Intrinsic	3.3%
450	Orthostatic intolerance	3.3%
451	Long QT Syndrome	3.3%
452	Familial Mediterranean Fever	3.3%
453	Platybasia	3.3%
454	Tricuspid Atresia	3.3%
455	Arrhythmogenic Right Ventricular Dysplasia	3.3%
456	Brain Diseases, Metabolic, Inborn	3.3%
457	Syphilis, Congenital	3.3%
458	Anemia, Sickle Cell	3.3%
459	Thalassemia	3.3%
460	Anosmia	3.3%
461	Ataxia	3.3%
462	Athetosis	3.3%
463	Catalepsy	3.3%
464	Dystonia	3.3%
465	Gonadal Dysgenesis	3.3%
466	Hemiplegia	3.3%
467	Locked-In Syndrome	3.3%
468	Meningeal Neoplasms	3.3%
469	Muscle Hypertonia	3.3%
470	Muscle hypotonia	3.3%
471	Myoclonus	3.3%
472	Myotonia	3.3%
473	Neuralgia	3.3%
474	Paraplegia	3.3%
475	Pseudobulbar Palsy	3.3%
476	Quadriplegia	3.3%
477	Spasm	3.3%
478	Spastic Paraplegia	3.3%
479	Status Epilepticus	3.3%
480	Taste Disorders	3.3%
481	Tremor	3.3%
482	Monoplegia	3.3%
483	Hypokinesia	3.3%
484	Paraparesis	3.3%
485	Bradykinesia	3.3%
486	Waxy flexibility	3.3%
487	Action Tremor	3.3%
488	Resting Tremor	3.3%
489	Dysosmia	3.3%
490	Bronchomalacia	3.3%
491	Quadriparesis	3.3%
492	Adrenogenital Syndrome	3.3%
493	Mercury Poisoning, Nervous System	3.3%
494	Olfaction Disorders	3.3%
495	Myokymia	3.3%
496	Lead Poisoning, Nervous System	3.3%
497	Vestibular Neuronitis	3.3%
498	Somatosensory Disorders	3.3%
499	Tracheomalacia	3.3%
500	Ovotesticular Disorders of Sex Development	3.3%
501	Neuropathic pain	3.3%
502	Hyperkinesia	3.3%
503	Intention tremor	3.3%
504	Alcohol Withdrawal Seizures	3.3%
505	Akathisia	3.3%
506	Restlessness	3.3%
507	Psychomotor Agitation	3.3%
508	Cerebral Palsy	3.3%
509	Epilepsies, Partial	3.3%
510	Epilepsy, Generalized	3.3%
511	Pseudotumor Cerebri	3.3%
512	Sciatic Neuropathy	3.3%
513	Hypertensive Encephalopathy	3.3%
514	Ulnar Neuropathies	3.3%
515	Lesion of Sciatic Nerve	3.3%
516	Simple Partial Seizures	3.3%
517	Epilepsy, Reflex	3.3%
518	Ulnar Neuritis	3.3%
519	Radial nerve compression	3.3%
520	Radial Tunnel Syndrome	3.3%
521	Peroneal Neuropathies	3.3%
522	Radial Neuropathy	3.3%
523	Median Neuropathy	3.3%
524	Sciatic Nerve Palsy	3.3%
525	Femoral Neuropathy	3.3%
526	Tibial Neuropathy	3.3%
527	Ulnar Nerve Palsy	3.3%
528	Postural Orthostatic Tachycardia Syndrome	3.3%
529	Radial nerve palsy	3.3%
530	Headache Disorders, Primary	3.3%
531	Headache Disorders, Secondary	3.3%
532	Medication overuse headache	3.3%
533	Brain Concussion	3.2%
534	Cubital Tunnel Syndrome	3.2%
535	Diffuse Axonal Injury	3.2%
536	Brain Stem Neoplasms	3.2%
537	Pituitary Adenoma	3.1%
538	Pituitary Neoplasms	3.1%
539	Optic Nerve Glioma	3.1%
540	Toxoplasmosis, Cerebral	3.1%
541	Mucopolysaccharidosis II	3%
542	Vertebral Artery Dissection	3%
543	Amnesia, Transient Global	3%
544	Gait Apraxia	3%
545	Meningitis, Cryptococcal	3%
546	Retrognathia	3%
547	Meningitis, Listeria	3%
548	Meningitis, Haemophilus	3%
549	Meningitis, Pneumococcal	3%
550	Frontotemporal dementia	3%
551	Albinism	2.9%
552	Aortopulmonary Septal Defect	2.9%
553	Double Outlet Right Ventricle	2.9%
554	Endocardial Cushion Defects	2.9%
555	Myocardial bridging	2.9%
556	Aorticopulmonary Septal Defect	2.9%
557	Basal Ganglia Hemorrhage	2.9%
558	Hyperandrogenism	2.9%
559	Choroid Plexus Papilloma	2.9%
560	Reflex, Abnormal	2.8%
561	Hyporeflexia	2.8%
562	Hyperreflexia	2.8%
563	Autoimmune Lymphoproliferative Syndrome	2.8%
564	Mitochondrial Encephalomyopathies	2.8%
565	Hand-Arm Vibration Syndrome	2.8%
566	Congenital Hyperinsulinism	2.8%
567	Chorioamnionitis	2.8%
568	MELAS Syndrome	2.8%
569	Angioedemas, Hereditary	2.7%
570	Vision Disorders	2.7%
571	Metamorphopsia	2.7%
572	Visual Impairment	2.7%
573	Pituitary Apoplexy	2.7%
574	Fibromyalgia	2.7%
575	Optic Neuropathy, Ischemic	2.7%
576	Anterior Ischemic Optic Neuropathy	2.7%
577	Central Nervous System Bacterial Infections	2.7%
578	Medial Tibial Stress Syndrome	2.7%
579	Polyradiculopathy	2.7%
580	Post-Traumatic Headache	2.7%
581	Tension Headache	2.7%
582	Epilepsy, Complex Partial	2.7%
583	Migraine Disorders	2.7%
584	Abdominal Migraine	2.7%
585	Status Migrainosus	2.7%
586	Cervicogenic Headache	2.7%
587	Brain Contusion	2.7%
588	Prognathism	2.7%
589	Brain Infarction	2.7%
590	Facial Hemiatrophy	2.7%
591	Melkersson-Rosenthal Syndrome	2.7%
592	Mitochondrial Myopathies	2.7%
593	Subarachnoid Hemorrhage, Traumatic	2.7%
594	Carotid Artery, Internal, Dissection	2.7%
595	Anisocoria	2.7%
596	Confusion	2.7%
597	Facial paralysis	2.7%
598	Lethargy	2.7%
599	Memory Disorders	2.7%
600	Muscle Cramp	2.7%
601	Perceptual Disorders	2.7%
602	Psychomotor Disorders	2.7%
603	Tonic Pupil	2.7%
604	Eosinophilia-Myalgia Syndrome	2.7%
605	Anhedonia	2.7%
606	Disorientation	2.7%
607	Facial Paresis	2.7%
608	Memory Loss	2.7%
609	Hemisensory Neglect	2.7%
610	Dysacusis	2.7%
611	Subacute Sclerosing Panencephalitis	2.7%
612	Sleep Bruxism	2.6%
613	Putaminal Hemorrhage	2.6%
614	Muscular Atrophy	2.6%
615	Respiratory Paralysis	2.6%
616	Galactosemias	2.6%
617	Urea Cycle Disorders, Inborn	2.6%
618	Tyrosinemias	2.6%
619	Tetany	2.6%
620	Fabry Disease	2.6%
621	Pituitary Diseases	2.6%
622	Infarction, Middle Cerebral Artery	2.6%
623	Infarction, Anterior Cerebral Artery	2.6%
624	Infarction, Posterior Cerebral Artery	2.6%
625	Paralysis, Obstetric	2.5%
626	Retinopathy of Prematurity	2.5%
627	Kernicterus	2.5%
628	Thoracic Outlet Syndrome	2.5%
629	Amino Acid Metabolism, Inborn Errors	2.5%
630	Carbohydrate Metabolism, Inborn Errors	2.5%
631	Metal Metabolism, Inborn Errors	2.5%
632	Progeria	2.5%
633	Lysosomal Storage Diseases	2.5%
634	Cytochrome-c Oxidase Deficiency	2.5%
635	Peroxisomal Disorders	2.5%
636	Wiskott-Aldrich Syndrome	2.5%
637	Bronchopulmonary Dysplasia	2.5%
638	Carotid Artery Diseases	2.5%
639	Brain Ischemia	2.5%
640	Esotropia	2.5%
641	Exotropia	2.5%
642	Hypotension, Orthostatic	2.5%
643	Sleep Apnea Syndromes	2.5%
644	Cerebrovascular accident	2.5%
645	Polymyositis	2.5%
646	Kluver-Bucy Syndrome	2.5%
647	Vasospasm, Intracranial	2.5%
648	Spinal Cord Ischemia	2.5%
649	Intracranial Arterial Diseases	2.5%
650	Post-Exercise Hypotension	2.5%
651	Auditory Perceptual Disorders	2.4%
652	Disorders of Excessive Somnolence	2.4%
653	Sleep Initiation and Maintenance Disorders	2.4%
654	Night Terrors	2.4%
655	Somnambulism	2.4%
656	Trigeminal Nerve Disorder	2.4%
657	Transient Insomnia	2.4%
658	Sleep Paralysis	2.4%
659	Chronic Insomnia	2.4%
660	REM Sleep Behavior Disorder	2.4%
661	Hypersomnia	2.4%
662	Hypokalemic periodic paralysis	2.4%
663	Mandibulofacial Dysostosis	2.4%
664	Dysgeusia	2.4%
665	Formication	2.4%
666	Hyperalgesia	2.4%
667	Hyperesthesia	2.4%
668	Hypesthesia	2.4%
669	Language Disorders	2.4%
670	Numbness	2.4%
671	Paresthesia	2.4%
672	Paraparesis, Spastic	2.4%
673	Trismus	2.4%
674	Epilepsia Partialis Continua	2.4%
675	Hypogeusia	2.4%
676	Meningeal Carcinomatosis	2.4%
677	Brown-Sequard Syndrome	2.4%
678	Lockjaw	2.4%
679	Allodynia	2.4%
680	Lead Poisoning, Nervous System, Childhood	2.4%
681	Lead Poisoning, Nervous System, Adult	2.4%
682	Ageusia	2.4%
683	Cluster Headache	2.4%
684	Romano-Ward Syndrome	2.4%
685	Migraine with Aura	2.4%
686	Familial Hemiplegic Migraine	2.4%
687	Chronic Paroxysmal Hemicrania	2.4%
688	SUNCT Syndrome	2.4%
689	Paroxysmal Hemicrania	2.4%
690	Tuberculosis, Central Nervous System	2.4%
691	Truncus Arteriosus, Persistent	2.4%
692	Goldenhar Syndrome	2.4%
693	Cerebral Infarction	2.4%
694	Brain Stem Infarctions	2.4%
695	Acoustic Neuroma	2.4%
696	Giant Cell Arteritis	2.4%
697	Temporal Arteritis	2.4%
698	Alexia	2.3%
699	Dyslexia	2.3%
700	Lateral Medullary Syndrome	2.3%
701	Consciousness Disorders	2.2%
702	Mental Retardation	2.2%
703	Muscle Weakness	2.2%
704	Depressed Level of Consciousness	2.2%
705	Mental deficiency	2.2%
706	Intellectual Disability	2.2%
707	Bell Palsy	2.2%
708	Catatonia	2.2%
709	Herpes Zoster Oticus	2.2%
710	Aphonia	2.2%
711	Sleep Deprivation	2.2%
712	Dysphonia	2.2%
713	Moyamoya Disease	2.2%
714	Homocystinuria	2.2%
715	Neurofibrosarcoma	2.2%
716	Glycogen storage disease type II	2.2%
717	Leigh Disease	2.2%
718	Sickle Cell Trait	2.2%
719	West Nile Fever	2.1%
720	Hematoma, Subdural	2.1%
721	Hematoma, Epidural, Cranial	2.1%
722	Empty Sella Syndrome	2.1%
723	Hyperpituitarism	2.1%
724	Hypopituitarism	2.1%
725	Hypophysitis	2.1%
726	Eye Injuries	2%
727	Ophthalmia Neonatorum	2%
728	Respiratory Distress Syndrome, Newborn	2%
729	Talipes	2%
730	Cerebral Arterial Diseases	2%
731	Vertebrobasilar Insufficiency	2%
732	Anterior Spinal Artery Syndrome	2%
733	Basilar Artery Stenosis	2%
734	Vertebral Artery Stenosis	2%
735	Sleep Apnea, Obstructive	2%
736	Sleep Apnea, Central	2%
737	Intracranial Hemorrhage, Hypertensive	2%
738	Transient Cerebral Ischemia	2%
739	Narcolepsy	2%
740	Trigeminal Neuralgia	2%
741	Kleine-Levin Syndrome	2%
742	Kearns-Sayre syndrome	2%
743	Cutis Laxa	2%
744	Agraphia	2%
745	Anomia	2%
746	Cluttering	2%
747	Language Development Disorders	2%
748	Speech Disorders	2%
749	Syncope	2%
750	Stupor	2%
751	Dysgraphia	2%
752	Presyncope	2%
753	Dyslalia	2%
754	Retinitis Pigmentosa	2%
755	Orbital Myositis	2%
756	Pigmentary retinopathy	2%
757	Porokeratosis	2%
758	Keratoderma, Palmoplantar	2%
759	Diplopia	2%
760	Muscle Rigidity	2%
761	Muscle Spasticity	2%
762	Scotoma	2%
763	Photophobia	2%
764	Cogwheel Rigidity	2%
765	Hemifacial Spasm	2%
766	Amaurosis	2%
767	Blindness	2%
768	Nuchal Rigidity	2%
769	Chronic granulomatous disease	2%
770	Reye Syndrome	2%
771	Neuroaspergillosis	2%
772	Pyomyositis	2%
773	Intracranial Embolism and Thrombosis	2%
774	Hepatic Encephalopathy	2%
775	Agnosia	2%
776	Apraxias	2%
777	Hallucinations	2%
778	Hemianopsia	2%
779	Hyperacusis	2%
780	Tinnitus	2%
781	Visual Agnosia	2%
782	Anosognosia	2%
783	Wernicke-Korsakoff Syndrome	2%
784	Phonophobia	2%
785	Hearing Loss	2%
786	Sarcopenia	1.9%
787	Myalgia	1.9%
788	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.9%
789	Hematoma, Subdural, Intracranial	1.8%
790	Hematoma, Subdural, Chronic	1.8%
791	Hematoma, Subdural, Acute	1.8%
792	Arteriovenous fistula	1.8%
793	Hyperprolactinemia	1.8%
794	Subclavian Steal Syndrome	1.8%
795	Pick Disease of the Brain	1.8%
796	Congenital clubfoot	1.8%
797	Vertical Talus	1.8%
798	Cataplexy	1.8%
799	Aphasia	1.8%
800	Articulation Disorders	1.8%
801	Echolalia	1.8%
802	Stuttering	1.8%
803	Dysphasia	1.8%
804	Pseudorabies	1.7%
805	Dysarthria	1.7%
806	Gaucher Disease	1.7%
807	Porphyrias, Hepatic	1.7%
808	Hoarseness	1.7%
809	Acute Chest Syndrome	1.7%
810	Amnesia	1.7%
811	Delirium	1.7%
812	Dissociative Amnesia	1.7%
813	Color blindness	1.7%
814	Global Amnesia	1.7%
815	Peutz-Jeghers Syndrome	1.7%
816	Hydrops Fetalis	1.6%
817	Thrombasthenia	1.6%
818	Antithrombin III Deficiency	1.6%
819	Protein C Deficiency	1.6%
820	Eye Burns	1.6%
821	Alcohol Withdrawal Delirium	1.6%
822	Afibrinogenemia	1.6%
823	Factor VII Deficiency	1.6%
824	Factor X Deficiency	1.6%
825	Factor XII Deficiency	1.6%
826	Hemophilia A	1.6%
827	Malaria, Cerebral	1.6%
828	Activated Protein C Resistance	1.6%
829	Factor II deficiency	1.6%
830	Factor VIII Deficiency	1.6%
831	Factor V deficiency	1.6%
832	Factor XI Deficiency	1.6%
833	Hypoprothrombinemias	1.6%
834	Meningioma	1.6%
835	Fanconi Anemia	1.6%
836	Nesidioblastosis	1.6%
837	Carotid Stenosis	1.6%
838	Intracranial Aneurysm	1.6%
839	Alkaptonuria	1.6%
840	Glycogen Storage Disease	1.6%
841	Hypophosphatasia	1.6%
842	Propionic acidemia	1.6%
843	Dihydropyrimidine Dehydrogenase Deficiency	1.6%
844	Cystinosis	1.6%
845	Neurocysticercosis	1.6%
846	Neurosyphilis	1.6%
847	Anemia, Diamond-Blackfan	1.6%
848	Amaurosis Fugax	1.6%
849	Blindness, Cortical	1.6%
850	Dyscalculia	1.6%
851	Intracranial Arteriosclerosis	1.6%
852	Cerebral Atherosclerosis	1.6%
853	Subarachnoid Hemorrhage	1.6%
854	Cerebral Arteriosclerosis	1.6%
855	Cerebral Hemorrhage	1.6%
856	Cerebral Thrombosis	1.6%
857	Intracranial Embolism	1.6%
858	Intracranial Thrombosis	1.6%
859	Deafness	1.6%
860	Hearing Loss, Sudden	1.6%
861	Gerstmann Syndrome	1.6%
862	Hearing Loss, Bilateral	1.6%
863	Hearing Loss, High-Frequency	1.6%
864	Hearing Loss, Mixed Conductive-Sensorineural	1.6%
865	Prosopagnosia	1.6%
866	Apraxia, Ideomotor	1.6%
867	Charles Bonnet Syndrome	1.6%
868	Hearing Loss, Unilateral	1.6%
869	Complete Hearing Loss	1.6%
870	Alien Hand Syndrome	1.6%
871	Deaf Mutism	1.6%
872	Tay-Sachs Disease	1.5%
873	Denys-Drash Syndrome	1.5%
874	Mutism	1.5%
875	Selective Mutism	1.5%
876	Acromegaly	1.5%
877	Multiple Endocrine Neoplasia	1.5%
878	Cerebral Amyloid Angiopathy	1.4%
879	Sinus Thrombosis, Intracranial	1.4%
880	Hyperphosphaturia	1.4%
881	Niemann-Pick Disease, Type C	1.4%
882	Congenital Hypothyroidism	1.4%
883	Dermatitis, Atopic	1.4%
884	Wernicke Encephalopathy	1.4%
885	AIDS Dementia Complex	1.4%
886	Waterhouse-Friderichsen Syndrome	1.4%
887	Dermatomyositis	1.4%
888	Corneal Scar	1.4%
889	Phantom pain	1.4%
890	Phantom Limb Pain	1.4%
891	Lyme Neuroborreliosis	1.4%
892	Mucopolysaccharidosis III	1.4%
893	Alexia, Pure	1.4%
894	Cavernous Sinus Thrombosis	1.4%
895	Sagittal Sinus Thrombosis	1.4%
896	Retrograde amnesia	1.3%
897	Amnesia, Anterograde	1.3%
898	Carotid Artery Thrombosis	1.3%
899	Hyaline Membrane Disease	1.3%
900	Hypolipoproteinemias	1.3%
901	Papillon-Lefevre Disease	1.3%
902	Hyperlipidemia, Familial Combined	1.3%
903	Hyperlipoproteinemia Type III	1.3%
904	Behcet Syndrome	1.2%
905	Corneal Perforation	1.2%
906	Glycogen Storage Disease Type I	1.2%
907	Glycogen Storage Disease Type V	1.2%
908	Nelson Syndrome	1.1%
909	Lactose Intolerance	1.1%
910	Variegate Porphyria	1.1%
911	Acute intermittent porphyria	1.1%
912	Porphyria Cutanea Tarda	1.1%
913	Hyperhomocysteinemia	1.1%
914	Renal Aminoacidurias	1.1%
915	Fanconi Syndrome	1.1%
916	Pseudohypoaldosteronism	1.1%
917	Liddle Syndrome	1.1%
918	Hyperlipoproteinemia Type IV	1.1%
919	Hyperlipoproteinemia Type V	1.1%
920	Prolactinoma	1%
921	Growth Hormone-Secreting Pituitary Adenoma	1%
922	Nephroblastoma	1%
923	Hypoalphalipoproteinemias	1%
924	Gout	0.9%
925	Multiple Endocrine Neoplasia Type 1	0.9%
926	Pseudohypoparathyroidism	0.9%
927	Renal tubular acidosis	0.9%
928	Adenomatous Polyposis Coli	0.9%
929	Cystinuria	0.8%
930	Glycosuria, Renal	0.7%
931	Arthritis, Gouty	0.7%
932	Familial Hypophosphatemic Rickets	0.7%

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