MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Anemia, Diamond-Blackfan

(UMLS:C1260899)

Definition:: A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)
UMLS ID:: C1260899
MeSH ID:: D029503

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.085.080.090|C15.378.071.750.500|C15.378.190.196.080.090

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.077.090

Synonym(s)

Anemia, Diamond-Blackfan

BLACKFAN-DIAMOND SYNDROME

Blackfan-Diamond

Blackfan-Diamond anemia

Chronic constitutional pure red cell anaemia

Chronic constitutional pure red cell anemia

Chronic constitutional pure red cell aplasia

Congenital Pure Red Cell Aplasia

Congenital hypoplastic anemia

10.

Congenital pure red cell anemia

11.

Congenital red cell aplasia

12.

DBA

13.

Diamond Blackfan anaemia

14.

Diamond Blackfan anemia

15.

Diamond-Blackfan Anemia

16.

Diamond-Blackfan anaemia

17.

Diamond-Blackfan anemia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Deferoxamine		3485251 9106087	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Fanconi Anemia	44.9%
2	Disseminated Intravascular Coagulation	33.6%
3	Protein S Deficiency	33.6%
4	Thrombocythemia, Essential	31.4%
5	Thrombasthenia	30.6%
6	Antithrombin III Deficiency	30.6%
7	Protein C Deficiency	30.6%
8	Anemia, Hemolytic	29.9%
9	Anemia, Macrocytic	29.9%
10	Anemia, Neonatal	28.6%
11	Anemia, Sickle Cell	27.9%
12	Thalassemia	27.9%
13	Blood Coagulation Disorders	27.6%
14	Blood Platelet Disorders	27.6%
15	Hemorrhagic Disorders	27.6%
16	Leukocyte Disorders	27.6%
17	Methemoglobinemia	27.6%
18	Pancytopenia	27.6%
19	Polycythemia	27.6%
20	Sulfhemoglobinemia	27.6%
21	Thrombophilia	27.6%
22	Erythrocytosis	27.6%
23	Bone Marrow Neoplasms	27.1%
24	Hemoglobinuria, Paroxysmal	26.9%
25	Afibrinogenemia	26.8%
26	Factor VII Deficiency	26.8%
27	Factor X Deficiency	26.8%
28	Factor XII Deficiency	26.8%
29	Hemophilia A	26.8%
30	Activated Protein C Resistance	26.8%
31	Factor II deficiency	26.8%
32	Factor VIII Deficiency	26.8%
33	Factor V deficiency	26.8%
34	Factor XI Deficiency	26.8%
35	Hypoprothrombinemias	26.8%
36	Thrombocytosis	24.3%
37	Wiskott-Aldrich Syndrome	24%
38	Transfusion Reaction	23.9%
39	Hypotensive Transfusion Reaction	23.9%
40	Pregnancy Complications, Hematologic	23.3%
41	Hematologic Neoplasms	23.3%
42	Pelger-Huet Anomaly	23.1%
43	Polycythemia Vera	23%
44	Vitamin K Deficiency	22.3%
45	MYELODYSPLASTIC SYNDROME	22.1%
46	Sickle Cell Trait	19.8%
47	Leukemoid Reaction	19.4%
48	Bone Marrow Diseases	18.8%
49	Anemia, Megaloblastic	18.7%
50	Lymphatic Diseases	17.6%
51	Acute Chest Syndrome	16.2%
52	Hemolytic-Uremic Syndrome	15.9%
53	Eosinophilia	15.6%
54	Hypoproteinemia	15.6%
55	Leukopenia	15.6%
56	Thrombocytopenia	15.6%
57	Leukostasis	15.6%
58	Purpura, Thrombotic Thrombocytopenic	15.3%
59	Agammaglobulinemia	15.1%
60	Anemia, Diamond-Blackfan	14.5%
61	Hydrops Fetalis	13.7%
62	Primary Myelofibrosis	13.5%
63	Myelofibrosis	13.5%
64	Myeloid Metaplasia	13.5%
65	bone marrow fibrosis	13.5%
66	Leukocytosis	13.2%
67	Paraproteinemias	13.2%
68	Pleocytosis	13.2%
69	Infectious Mononucleosis	13.1%
70	Autoimmune thrombocytopenia	12.7%
71	Immune thrombocytopenic purpura	12.7%
72	Chronic granulomatous disease	12.6%
73	Waldenstrom Macroglobulinemia	12.4%
74	Cryoglobulinemia	12.2%
75	Monoclonal Gammopathy of Undetermined Significance	12.2%
76	Atypical Hemolytic Uremic Syndrome	11.5%
77	Hypergammaglobulinemia	11.4%
78	Leukemia, Myelomonocytic, Chronic	11.3%
79	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	11.3%
80	Transfusion-Related Acute Lung Injury	11.3%
81	Ecchymosis	11.2%
82	Petechiae	11.2%
83	Purpura	11.2%
84	Lymphatic Abnormalities	11.1%
85	Aicardi's syndrome	11%
86	Anemia, Pernicious	10.9%
87	Autoimmune Lymphoproliferative Syndrome	10.8%
88	Purpura, Hyperglobulinemic	10.8%
89	Fragile X Syndrome	10.7%
90	Heavy Chain Disease	10.7%
91	CHARGE Syndrome	10.4%
92	Neoplastic Syndromes, Hereditary	10.2%
93	Cystic Fibrosis	10.2%
94	Ichthyosis, X-Linked	10%
95	Multiple Epiphyseal Dysplasia	9.9%
96	Osteochondrodysplasias	9.9%
97	Werner Syndrome	9.9%
98	Myasthenic Syndromes, Congenital	9.9%
99	Albinism	9.9%
100	Multiple Myeloma	9.8%
101	Muscular Dystrophy, Duchenne	9.7%
102	Agranulocytosis	9.7%
103	Lymphocytosis	9.7%
104	Hypoalbuminemia	9.7%
105	Hypereosinophilic syndrome	9.7%
106	Thrombotic Microangiopathies	9.7%
107	Waterhouse-Friderichsen Syndrome	9.7%
108	Thrombocytopenic purpura	9.4%
109	Beckwith-Wiedemann Syndrome	9.3%
110	Lymphangiectasis, Intestinal	9.3%
111	Wolf-Hirschhorn Syndrome	9.3%
112	Pseudoxanthoma Elasticum	9.3%
113	Kernicterus	9.2%
114	Adenitis	9.2%
115	Histiocytosis	9.2%
116	Lymphadenitis	9.2%
117	Lymphangitis	9.2%
118	Lymphedema	9.2%
119	Splenic Diseases	9.2%
120	Thymus Hyperplasia	9.2%
121	Pseudolymphoma	9.2%
122	Lymphadenopathy	9.2%
123	Cockayne Syndrome	9.2%
124	Nail-Patella Syndrome	9.2%
125	Alstrom Syndrome	9%
126	Anemia	8.9%
127	Mucopolysaccharidosis II	8.8%
128	Dwarfism	8.7%
129	Muscular Dystrophy	8.5%
130	Osteogenesis Imperfecta	8.5%
131	Menkes Kinky Hair Syndrome	8.3%
132	Rett Syndrome	8.3%
133	Smith-Magenis syndrome	8.3%
134	Lymphopenia	8.2%
135	Cri-du-Chat Syndrome	8.2%
136	Down Syndrome	8.2%
137	Trisomy 21	8.2%
138	Job Syndrome	8.1%
139	Kartagener Syndrome	8.1%
140	Familial Mediterranean Fever	7.8%
141	Lymphocele	7.8%
142	Lymphoproliferative Disorders	7.8%
143	Leukemia, Myeloid, Chronic-Phase	7.8%
144	Holoprosencephaly	7.7%
145	POEMS Syndrome	7.7%
146	Thymus Neoplasms	7.7%
147	Marfan Syndrome	7.6%
148	Angioedemas, Hereditary	7.3%
149	Ectodermal Dysplasia	7.3%
150	Aplasia Cutis Congenita	7.3%
151	Eosinophilic Granuloma	7.3%
152	Prader-Willi Syndrome	7.2%
153	Smith-Lemli-Opitz Syndrome	7.1%
154	Myotonic Dystrophy	7.1%
155	Eosinophilia-Myalgia Syndrome	7%
156	Neuronal Ceroid-Lipofuscinoses	7%
157	Adrenoleukodystrophy	7%
158	Shwartzman Phenomenon	7%
159	Hemangioma, Cavernous	6.9%
160	Scurvy	6.9%
161	Purpura Fulminans	6.9%
162	Rubinstein-Taybi Syndrome	6.8%
163	Tuberous Sclerosis	6.8%
164	Deformity	6.8%
165	Neutropenia	6.8%
166	Kallmann Syndrome	6.7%
167	Sjogren-Larsson Syndrome	6.6%
168	Mucocutaneous Lymph Node Syndrome	6.6%
169	Hepatolenticular Degeneration	6.5%
170	Amino Acid Metabolism, Inborn Errors	6.5%
171	Carbohydrate Metabolism, Inborn Errors	6.5%
172	Metal Metabolism, Inborn Errors	6.5%
173	Progeria	6.5%
174	Lysosomal Storage Diseases	6.5%
175	Cytochrome-c Oxidase Deficiency	6.5%
176	Peroxisomal Disorders	6.5%
177	Polycystic Kidney Diseases	6.5%
178	Williams Syndrome	6.5%
179	Refsum Disease	6.5%
180	Primary Ciliary Dyskinesia	6.4%
181	Fabry Disease	6.4%
182	Amyloid Neuropathies, Familial	6.2%
183	Glycogen storage disease type II	6%
184	Retinal Dysplasia	6%
185	Aniridia	5.9%
186	Epidermolysis Bullosa	5.8%
187	Galactosemias	5.8%
188	Urea Cycle Disorders, Inborn	5.8%
189	Tyrosinemias	5.8%
190	Pulmonary Eosinophilia	5.7%
191	Eosinophilic Pneumonia	5.7%
192	Fetal Diseases	5.7%
193	Cutis Laxa	5.7%
194	Retinitis Pigmentosa	5.6%
195	Pigmentary retinopathy	5.6%
196	Porokeratosis	5.6%
197	Keratoderma, Palmoplantar	5.6%
198	Welander Distal Myopathy	5.5%
199	Ataxia Telangiectasia	5.4%
200	Mucopolysaccharidosis III	5.3%
201	Optic Atrophy, Hereditary, Leber	5.3%
202	Febrile Neutropenia	5.3%
203	Hyperphosphaturia	5.3%
204	Canavan Disease	5.2%
205	Alexander Disease	5.2%
206	Elephantiasis	5.2%
207	Hypersplenism	5.2%
208	Sarcoidosis	5.2%
209	Elephantiasis Nostras Verrucosa	5.2%
210	Zellweger Syndrome	5.1%
211	Niemann-Pick Disease, Type C	5.1%
212	Duane Retraction Syndrome	5%
213	Porphyrias, Hepatic	5%
214	Gaucher Disease	4.9%
215	Peutz-Jeghers Syndrome	4.9%
216	Myotonia Congenita	4.9%
217	Brain Diseases, Metabolic, Inborn	4.9%
218	Classical Lissencephalies and Subcortical Band Heterotopias	4.9%
219	Dystonia Musculorum Deformans	4.9%
220	Homocystinuria	4.9%
221	Lafora Disease	4.8%
222	Unverricht-Lundborg Syndrome	4.8%
223	Alkaptonuria	4.8%
224	Glycogen Storage Disease	4.8%
225	Hypophosphatasia	4.8%
226	Propionic acidemia	4.8%
227	Dihydropyrimidine Dehydrogenase Deficiency	4.8%
228	Cystinosis	4.8%
229	Leigh Disease	4.8%
230	Polycystic Kidney, Autosomal Dominant	4.8%
231	Hyperkeratosis, Epidermolytic	4.7%
232	Tay-Sachs Disease	4.5%
233	Meconium Aspiration Syndrome	4.5%
234	Multiple Endocrine Neoplasia	4.5%
235	Xeroderma Pigmentosum	4.4%
236	Congenital Hypothyroidism	4.4%
237	Granuloma	4.4%
238	Histiocytic Disorders, Malignant	4.4%
239	Splenic Infarction	4.4%
240	Splenic Neoplasms	4.4%
241	Dermatitis, Atopic	4.4%
242	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.4%
243	Histiocytosis, Langerhans-Cell	4.3%
244	Tumor Lysis Syndrome	4.3%
245	Charcot-Marie-Tooth Disease	4.3%
246	Antley-Bixler Syndrome Phenotype	4.3%
247	Hypolipoproteinemias	4.1%
248	Papillon-Lefevre Disease	4.1%
249	Hyperlipidemia, Familial Combined	4.1%
250	Hyperlipoproteinemia Type III	4.1%
251	Xeroderma	4.1%
252	Mobius Syndrome	4.1%
253	Basal Cell Nevus Syndrome	4%
254	Glycogen Storage Disease Type I	4%
255	Glycogen Storage Disease Type V	4%
256	Abdominal Cramps	3.9%
257	Abnormalities, Drug-Induced	3.9%
258	Amniotic Band Syndrome	3.9%
259	Asphyxia Neonatorum	3.9%
260	Infant, Premature, Diseases	3.9%
261	Situs Inversus	3.9%
262	Infantile Colic	3.9%
263	Behcet Syndrome	3.9%
264	Splenic Rupture	3.8%
265	Lymphoma	3.8%
266	Thymoma	3.7%
267	Sezary Syndrome	3.7%
268	Familial Periodic Paralysis	3.7%
269	Klinefelter Syndrome	3.7%
270	Lactose Intolerance	3.6%
271	Variegate Porphyria	3.6%
272	Acute intermittent porphyria	3.6%
273	Porphyria Cutanea Tarda	3.6%
274	Hyperhomocysteinemia	3.6%
275	Renal Aminoacidurias	3.6%
276	Fanconi Syndrome	3.6%
277	Pseudohypoaldosteronism	3.6%
278	Liddle Syndrome	3.6%
279	Hyperlipoproteinemia Type IV	3.6%
280	Hyperlipoproteinemia Type V	3.6%
281	Huntington Disease	3.6%
282	Hypoalphalipoproteinemias	3.4%
283	Eye Abnormalities	3.4%
284	Turner Syndrome	3.4%
285	Cardiovascular Abnormalities	3.4%
286	Skin Abnormalities	3.3%
287	Congenital Microtia	3.3%
288	Persistent Fetal Circulation Syndrome	3.3%
289	Gout	3.3%
290	Congenital diaphragmatic hernia	3.3%
291	Umbilical hernia	3.3%
292	Multiple Endocrine Neoplasia Type 1	3.3%
293	Pseudohypoparathyroidism	3.3%
294	Nephroblastoma	3.3%
295	Anencephaly	3.3%
296	Friedreich Ataxia	3.2%
297	Lymphohistiocytosis, Hemophagocytic	3.2%
298	Erdheim-Chester Disease	3.2%
299	Renal tubular acidosis	3.2%
300	Hypokalemic periodic paralysis	3%
301	Cystinuria	3%
302	Familial Hypophosphatemic Rickets	3%
303	Adenomatous Polyposis Coli	3%
304	Urogenital Abnormalities	2.9%
305	Neonatal Abstinence Syndrome	2.9%
306	Maxillofacial Abnormalities	2.9%
307	Dural Arteriovenous Fistula	2.9%
308	Dextrocardia	2.9%
309	Fetal Growth Retardation	2.8%
310	Fetal Hypoxia	2.8%
311	Congenital nystagmus	2.8%
312	Fetal Alcohol Spectrum Disorders	2.8%
313	Toxoplasmosis, Congenital	2.8%
314	Syphilis, Congenital	2.8%
315	Malignant histiocytosis	2.7%
316	Sarcoidosis, Pulmonary	2.7%
317	Histiocytic sarcoma	2.7%
318	Arthritis, Gouty	2.7%
319	Glycosuria, Renal	2.6%
320	Prune Belly Syndrome	2.6%
321	Twins, Conjoined	2.6%
322	Waardenburg Syndrome	2.6%
323	Congenital Hyperinsulinism	2.5%
324	Chorioamnionitis	2.5%
325	Scimitar Syndrome	2.3%
326	Splenosis	2.3%
327	Hodgkin Disease	2.3%
328	Lymphoma, Non-Hodgkin	2.3%
329	Leukemia, T-Cell	2.3%
330	Leukemia, B-Cell	2.3%
331	Denys-Drash Syndrome	2.3%
332	Acrocephalosyndactylia	2.3%
333	Microcephaly	2.2%
334	MELAS Syndrome	2.2%
335	Macrocephaly	2.2%
336	Anophthalmos	2.2%
337	Anus, Imperforate	2.2%
338	Hydranencephaly	2.2%
339	Microphthalmos	2.2%
340	Neural Tube Defects	2.2%
341	Paralysis, Obstetric	2.2%
342	Retinopathy of Prematurity	2.2%
343	Tethered Cord Syndrome	2.2%
344	Iniencephaly	2.2%
345	Craniorachischisis	2.2%
346	Limb Deformities, Congenital	2.2%
347	Exencephaly	2.2%
348	Septo-Optic Dysplasia	2.2%
349	Craniofacial Abnormalities	2.2%
350	Cortical Dysplasia	2.2%
351	Malformations of Cortical Development	2.2%
352	Anorectal Malformations	2.2%
353	Abnormalities, Radiation-Induced	2.2%
354	Bloom Syndrome	2.2%
355	Bronchopulmonary Dysplasia	2.2%
356	Craniosynostosis	2.2%
357	Syndactyly	2.2%
358	Brachycephaly	2.2%
359	Composite Lymphoma	2%
360	Lymphangioleiomyomatosis	2%
361	Porencephaly	2%
362	Noonan Syndrome	2%
363	Ophthalmia Neonatorum	1.9%
364	Cleft Palate	1.9%
365	Blepharophimosis	1.9%
366	Laryngostenosis	1.9%
367	Mouth Abnormalities	1.9%
368	Respiratory Distress Syndrome, Newborn	1.9%
369	Esophageal Atresia	1.9%
370	Intestinal Atresia	1.9%
371	Horseshoe Kidney	1.9%
372	Pectus excavatum	1.9%
373	Klippel-Feil Syndrome	1.9%
374	Gastroschisis	1.9%
375	Synostosis	1.9%
376	Acrodermatitis	1.9%
377	Gianotti-Crosti Syndrome	1.9%
378	Jaw Abnormalities	1.8%
379	Poland Syndrome	1.8%
380	Arthrogryposis	1.7%
381	Choanal Atresia	1.7%
382	Tracheobronchomegaly	1.7%
383	Laryngocele	1.7%
384	Choledochal Cyst	1.7%
385	Hermaphroditism	1.7%
386	Disorders of Sex Development	1.7%
387	Cryptorchidism	1.7%
388	Hypospadias	1.7%
389	Central Nervous System Cysts	1.6%
390	Dandy-Walker Syndrome	1.6%
391	Leukomalacia, Periventricular	1.6%
392	Amelia	1.6%
393	Arachnodactyly	1.6%
394	Ectopia Cordis	1.6%
395	Ectromelia	1.6%
396	Hemimelia	1.6%
397	Meningomyelocele	1.6%
398	Phocomelia	1.6%
399	Sirenomelia	1.6%
400	Spina Bifida	1.6%
401	Polydactyly	1.6%
402	Brachydactyly	1.6%
403	Plagiocephaly	1.6%
404	Lower Extremity Deformities, Congenital	1.6%
405	Upper Extremity Deformities, Congenital	1.6%
406	Single umbilical artery	1.6%
407	Nesidioblastosis	1.6%
408	Lymphoma, Follicular	1.6%
409	T-Cell Lymphoma	1.6%
410	Mantle cell lymphoma	1.6%
411	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
412	Leukemia, Large Granular Lymphocytic	1.6%
413	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
414	Micrognathism	1.5%
415	Pierre Robin Syndrome	1.5%
416	Laryngomalacia	1.5%
417	Pectus carinatum	1.5%
418	Bladder Exstrophy	1.5%
419	Epispadias	1.5%
420	Multicystic Dysplastic Kidney	1.5%
421	Retrognathia	1.4%
422	Aortic coarctation	1.4%
423	Cor Triatriatum	1.4%
424	Coronary Vessel Anomalies	1.4%
425	Dental Enamel Hypoplasia	1.4%
426	Patent ductus arteriosus	1.4%
427	Ebstein Anomaly	1.4%
428	Heart Septal Defects	1.4%
429	Hyaline Membrane Disease	1.4%
430	Hypodontia	1.4%
431	Macrostomia	1.4%
432	Meningocele	1.4%
433	Microstomia	1.4%
434	Tetralogy of Fallot	1.4%
435	Transposition of Great Vessels	1.4%
436	Hypoplastic Left Heart Syndrome	1.4%
437	May-Thurner Syndrome	1.4%
438	Encephalocele	1.4%
439	Craniofacial Dysostosis	1.4%
440	Wolff-Parkinson-White Syndrome	1.4%
441	Dermal Sinus	1.3%
442	Spina Bifida Cystica	1.3%
443	Spina Bifida Occulta	1.3%
444	Lissencephaly	1.3%
445	Polymicrogyria	1.3%
446	Pachygyria	1.3%
447	Schizencephaly	1.3%
448	Periventricular Nodular Heterotopia	1.3%
449	Hyperandrogenism	1.3%
450	Prognathism	1.3%
451	Lymphoma, T-Cell, Cutaneous	1.3%
452	Lymphoma, AIDS-Related	1.3%
453	Enteropathy-Associated T-Cell Lymphoma	1.3%
454	Primary Effusion Lymphoma	1.3%
455	Long QT Syndrome	1.2%
456	Platybasia	1.2%
457	Tricuspid Atresia	1.2%
458	Arrhythmogenic Right Ventricular Dysplasia	1.2%
459	Gonadal Dysgenesis	1.2%
460	Bronchomalacia	1.2%
461	Adrenogenital Syndrome	1.2%
462	Tracheomalacia	1.2%
463	Ovotesticular Disorders of Sex Development	1.2%
464	Aortopulmonary Septal Defect	1.1%
465	Double Outlet Right Ventricle	1.1%
466	Endocardial Cushion Defects	1.1%
467	Myocardial bridging	1.1%
468	Aorticopulmonary Septal Defect	1.1%
469	Lymphomatoid Granulomatosis	1.1%
470	Mycosis Fungoides	1.1%
471	Lymphomatoid Papulosis	1.1%
472	Plasmablastic lymphoma	1.1%
473	Truncus Arteriosus, Persistent	1%
474	Goldenhar Syndrome	1%
475	Mandibulofacial Dysostosis	1%
476	Romano-Ward Syndrome	1%
477	Burkitt Lymphoma	1%
478	Talipes	0.9%
479	Congenital clubfoot	0.9%
480	Vertical Talus	0.9%
481	Arteriovenous fistula	0.8%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234