MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Beckwith-Wiedemann Syndrome

(UMLS:C0004903)

Definition:: A syndrome of multiple defects characterized primarily by umbilical hernia (HERNIA, UMBILICAL); MACROGLOSSIA; and GIGANTISM; and secondarily by visceromegaly; HYPOGLYCEMIA; and ear abnormalities.
UMLS ID:: C0004903
MeSH ID:: D001506

Classification:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.133|C16.131.260.080|C16.320.180.080

Synonym(s)

Beckwith-Wiedemann Syndrome

BECKWITH-WIEDEMANN SYNDROME

Beckwith syndrome

Beckwith's syndrome

Beckwith-Wiedemann

Beckwith-Wiedemann syndrome

Beckwith-Wiedemann syndrome (BW, BWS)

Exomphalos-macroglossia-gigantism syndrome

Wiedemann syndrome

10.

Wiedemann-Beckwith syndrome

11.

Wiedemann-Beckwith syndrome (WBS)

12.

Wiedemann-Beckwith-Combs syndrome

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 2	US FAERS
2	Atomoxetine Hydrochloride		OFFSIDES
3	Nizatidine		OFFSIDES
4	fludrocortisone acetate		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Wolf-Hirschhorn Syndrome	68.9%
2	Smith-Magenis syndrome	59.6%
3	Cri-du-Chat Syndrome	58.8%
4	Down Syndrome	58.8%
5	Trisomy 21	58.8%
6	Holoprosencephaly	55%
7	Prader-Willi Syndrome	51.2%
8	Rubinstein-Taybi Syndrome	47.9%
9	CHARGE Syndrome	41.6%
10	Aicardi's syndrome	38.6%
11	Ectodermal Dysplasia	38.3%
12	Aplasia Cutis Congenita	38.3%
13	Williams Syndrome	37.6%
14	Prune Belly Syndrome	36.7%
15	Waardenburg Syndrome	36.7%
16	Fragile X Syndrome	36.7%
17	Nail-Patella Syndrome	35.9%
18	Abnormalities, Drug-Induced	35.6%
19	Situs Inversus	35.6%
20	Marfan Syndrome	32%
21	Cockayne Syndrome	31%
22	Kartagener Syndrome	31%
23	Polycystic Kidney Diseases	30.1%
24	Mobius Syndrome	29.8%
25	Eye Abnormalities	29.6%
26	Cardiovascular Abnormalities	29.6%
27	Bloom Syndrome	29.3%
28	Skin Abnormalities	28.8%
29	Lymphatic Abnormalities	28.8%
30	Congenital Microtia	28.8%
31	Alstrom Syndrome	28.4%
32	Congenital diaphragmatic hernia	28.2%
33	Anencephaly	27.1%
34	Smith-Lemli-Opitz Syndrome	26.9%
35	Primary Ciliary Dyskinesia	26.6%
36	Urogenital Abnormalities	24.7%
37	Ichthyosis, X-Linked	24.1%
38	Cystic Fibrosis	23.8%
39	Maxillofacial Abnormalities	23.4%
40	Dural Arteriovenous Fistula	23.4%
41	Twins, Conjoined	23.3%
42	Dextrocardia	23.2%
43	Polycystic Kidney, Autosomal Dominant	22.3%
44	Beckwith-Wiedemann Syndrome	22.2%
45	Xeroderma	22.1%
46	Klinefelter Syndrome	21.9%
47	Turner Syndrome	21.5%
48	Fetal Diseases	21.1%
49	Neoplastic Syndromes, Hereditary	21.1%
50	POEMS Syndrome	20.8%
51	Retinal Dysplasia	20.5%
52	Aniridia	20.3%
53	Multiple Epiphyseal Dysplasia	20.3%
54	Osteochondrodysplasias	20.3%
55	Pelger-Huet Anomaly	20.3%
56	Werner Syndrome	20.3%
57	Myasthenic Syndromes, Congenital	20.3%
58	Epidermolysis Bullosa	20%
59	Classical Lissencephalies and Subcortical Band Heterotopias	19.6%
60	Anophthalmos	18.9%
61	Anus, Imperforate	18.9%
62	Hydranencephaly	18.9%
63	Microphthalmos	18.9%
64	Neural Tube Defects	18.9%
65	Tethered Cord Syndrome	18.9%
66	Iniencephaly	18.9%
67	Craniorachischisis	18.9%
68	Limb Deformities, Congenital	18.9%
69	Exencephaly	18.9%
70	Septo-Optic Dysplasia	18.9%
71	Craniofacial Abnormalities	18.9%
72	Cortical Dysplasia	18.9%
73	Malformations of Cortical Development	18.9%
74	Anorectal Malformations	18.9%
75	Anemia, Sickle Cell	18.9%
76	Thalassemia	18.9%
77	Muscular Dystrophy, Duchenne	18.8%
78	Zellweger Syndrome	18.7%
79	Scimitar Syndrome	18.5%
80	Albinism	18.3%
81	Microcephaly	18%
82	Macrocephaly	18%
83	Sjogren-Larsson Syndrome	17.8%
84	Basal Cell Nevus Syndrome	17.6%
85	Genetic Diseases, Inborn	17.5%
86	Abnormalities, Radiation-Induced	17.5%
87	Dwarfism	17.4%
88	Kallmann Syndrome	17.4%
89	Acrocephalosyndactylia	17.3%
90	Craniosynostosis	17.2%
91	Syndactyly	17.2%
92	Brachycephaly	17.2%
93	Muscular Dystrophy	16.8%
94	Osteogenesis Imperfecta	16.8%
95	Familial Mediterranean Fever	16.7%
96	Rett Syndrome	16.3%
97	Porencephaly	16.3%
98	Tuberous Sclerosis	16.2%
99	Mucopolysaccharidosis II	16.2%
100	Pseudoxanthoma Elasticum	16.1%
101	Blepharophimosis	15.9%
102	Laryngostenosis	15.9%
103	Mouth Abnormalities	15.9%
104	Esophageal Atresia	15.7%
105	Intestinal Atresia	15.7%
106	Horseshoe Kidney	15.7%
107	Pectus excavatum	15.7%
108	Klippel-Feil Syndrome	15.6%
109	Gastroschisis	15.6%
110	Synostosis	15.6%
111	Acrodermatitis	15.6%
112	Lymphangiectasis, Intestinal	15.6%
113	Noonan Syndrome	15.6%
114	Gianotti-Crosti Syndrome	15.6%
115	Meconium Aspiration Syndrome	15.4%
116	Refsum Disease	15.3%
117	Abdominal Cramps	15.3%
118	Amniotic Band Syndrome	15.3%
119	Asphyxia Neonatorum	15.3%
120	Infant, Premature, Diseases	15.3%
121	Infantile Colic	15.3%
122	Menkes Kinky Hair Syndrome	15%
123	Hyperkeratosis, Epidermolytic	15%
124	Cleft Palate	14.8%
125	Charcot-Marie-Tooth Disease	14.7%
126	Antley-Bixler Syndrome Phenotype	14.7%
127	Wiskott-Aldrich Syndrome	14.7%
128	Xeroderma Pigmentosum	14.6%
129	Autoimmune Lymphoproliferative Syndrome	14.6%
130	Jaw Abnormalities	14.3%
131	Angioedemas, Hereditary	14.2%
132	Poland Syndrome	14.2%
133	Sickle Cell Trait	14%
134	Amelia	13.9%
135	Arachnodactyly	13.9%
136	Ectopia Cordis	13.9%
137	Ectromelia	13.9%
138	Hemimelia	13.9%
139	Meningomyelocele	13.9%
140	Phocomelia	13.9%
141	Sirenomelia	13.9%
142	Spina Bifida	13.9%
143	Polydactyly	13.9%
144	Brachydactyly	13.9%
145	Plagiocephaly	13.9%
146	Lower Extremity Deformities, Congenital	13.9%
147	Upper Extremity Deformities, Congenital	13.9%
148	Single umbilical artery	13.9%
149	Arthrogryposis	13.7%
150	Choanal Atresia	13.7%
151	Tracheobronchomegaly	13.7%
152	Laryngocele	13.7%
153	Choledochal Cyst	13.6%
154	Hermaphroditism	13.6%
155	Disorders of Sex Development	13.6%
156	Cryptorchidism	13.5%
157	Hypospadias	13.5%
158	Central Nervous System Cysts	13.4%
159	Amino Acid Metabolism, Inborn Errors	13.3%
160	Carbohydrate Metabolism, Inborn Errors	13.3%
161	Dandy-Walker Syndrome	13.3%
162	Metal Metabolism, Inborn Errors	13.3%
163	Progeria	13.3%
164	Lysosomal Storage Diseases	13.3%
165	Cytochrome-c Oxidase Deficiency	13.3%
166	Peroxisomal Disorders	13.3%
167	Neuronal Ceroid-Lipofuscinoses	13.3%
168	Myotonic Dystrophy	13.2%
169	Adrenoleukodystrophy	12.3%
170	Anemia, Neonatal	12.2%
171	Persistent Fetal Circulation Syndrome	12.2%
172	Micrognathism	12.1%
173	Pierre Robin Syndrome	12.1%
174	Umbilical hernia	12%
175	Laryngomalacia	12%
176	Pectus carinatum	11.9%
177	Hepatolenticular Degeneration	11.8%
178	Bladder Exstrophy	11.7%
179	Epispadias	11.7%
180	Multicystic Dysplastic Kidney	11.6%
181	Aortic coarctation	11.6%
182	Cor Triatriatum	11.6%
183	Coronary Vessel Anomalies	11.6%
184	Dental Enamel Hypoplasia	11.6%
185	Patent ductus arteriosus	11.6%
186	Ebstein Anomaly	11.6%
187	Heart Septal Defects	11.6%
188	Hypodontia	11.6%
189	Macrostomia	11.6%
190	Meningocele	11.6%
191	Microstomia	11.6%
192	Tetralogy of Fallot	11.6%
193	Transposition of Great Vessels	11.6%
194	Hypoplastic Left Heart Syndrome	11.6%
195	May-Thurner Syndrome	11.6%
196	Encephalocele	11.6%
197	Craniofacial Dysostosis	11.5%
198	Fabry Disease	11.5%
199	Dermal Sinus	11.5%
200	Spina Bifida Cystica	11.5%
201	Wolff-Parkinson-White Syndrome	11.5%
202	Spina Bifida Occulta	11.5%
203	Lissencephaly	11.5%
204	Polymicrogyria	11.5%
205	Pachygyria	11.5%
206	Schizencephaly	11.5%
207	Periventricular Nodular Heterotopia	11.5%
208	Amyloid Neuropathies, Familial	11.4%
209	Cutis Laxa	11.2%
210	Retinitis Pigmentosa	11.2%
211	Pigmentary retinopathy	11.2%
212	Porokeratosis	11.1%
213	Keratoderma, Palmoplantar	11.1%
214	Acute Chest Syndrome	11.1%
215	Chronic granulomatous disease	11%
216	Welander Distal Myopathy	11%
217	Glycogen storage disease type II	11%
218	Retrognathia	10.9%
219	Galactosemias	10.8%
220	Urea Cycle Disorders, Inborn	10.8%
221	Tyrosinemias	10.8%
222	Neonatal Abstinence Syndrome	10.3%
223	Hyperandrogenism	10.3%
224	Mucopolysaccharidosis III	10.1%
225	Fetal Growth Retardation	10.1%
226	Ataxia Telangiectasia	10.1%
227	Fetal Hypoxia	10.1%
228	Congenital nystagmus	10.1%
229	Fetal Alcohol Spectrum Disorders	10.1%
230	Toxoplasmosis, Congenital	10%
231	Long QT Syndrome	10%
232	Platybasia	10%
233	Tricuspid Atresia	10%
234	Arrhythmogenic Right Ventricular Dysplasia	10%
235	Syphilis, Congenital	9.9%
236	Gonadal Dysgenesis	9.9%
237	Bronchomalacia	9.9%
238	Adrenogenital Syndrome	9.9%
239	Tracheomalacia	9.9%
240	Ovotesticular Disorders of Sex Development	9.9%
241	Prognathism	9.9%
242	Alkaptonuria	9.9%
243	Glycogen Storage Disease	9.9%
244	Hypophosphatasia	9.9%
245	Propionic acidemia	9.9%
246	Dihydropyrimidine Dehydrogenase Deficiency	9.9%
247	Cystinosis	9.9%
248	Optic Atrophy, Hereditary, Leber	9.8%
249	Hyperphosphaturia	9.8%
250	Duane Retraction Syndrome	9.7%
251	Canavan Disease	9.6%
252	Alexander Disease	9.6%
253	Porphyrias, Hepatic	9.6%
254	Aortopulmonary Septal Defect	9.5%
255	Double Outlet Right Ventricle	9.5%
256	Endocardial Cushion Defects	9.5%
257	Myocardial bridging	9.5%
258	Aorticopulmonary Septal Defect	9.5%
259	Peutz-Jeghers Syndrome	9.5%
260	Myotonia Congenita	9.5%
261	Thrombasthenia	9.5%
262	Antithrombin III Deficiency	9.5%
263	Protein C Deficiency	9.5%
264	Brain Diseases, Metabolic, Inborn	9.5%
265	Afibrinogenemia	9.4%
266	Dystonia Musculorum Deformans	9.4%
267	Factor VII Deficiency	9.4%
268	Factor X Deficiency	9.4%
269	Factor XII Deficiency	9.4%
270	Hemophilia A	9.4%
271	Activated Protein C Resistance	9.4%
272	Factor II deficiency	9.4%
273	Factor VIII Deficiency	9.4%
274	Factor V deficiency	9.4%
275	Factor XI Deficiency	9.4%
276	Hypoprothrombinemias	9.4%
277	Fanconi Anemia	9.4%
278	Lafora Disease	9.4%
279	Unverricht-Lundborg Syndrome	9.4%
280	Anemia, Diamond-Blackfan	9.3%
281	Homocystinuria	9%
282	Gaucher Disease	9%
283	Leigh Disease	8.9%
284	Deformity	8.8%
285	Congenital Hyperinsulinism	8.7%
286	Chorioamnionitis	8.6%
287	Multiple Endocrine Neoplasia	8.5%
288	Truncus Arteriosus, Persistent	8.5%
289	Goldenhar Syndrome	8.5%
290	Congenital Hypothyroidism	8.4%
291	Dermatitis, Atopic	8.3%
292	Tay-Sachs Disease	8.2%
293	Hypolipoproteinemias	8.2%
294	Papillon-Lefevre Disease	8.2%
295	Mandibulofacial Dysostosis	8.2%
296	Hyperlipidemia, Familial Combined	8.2%
297	Glycogen Storage Disease Type I	8.2%
298	Glycogen Storage Disease Type V	8.2%
299	Hyperlipoproteinemia Type III	8.2%
300	Romano-Ward Syndrome	8.2%
301	Hydrops Fetalis	8.1%
302	Paralysis, Obstetric	8.1%
303	Retinopathy of Prematurity	8.1%
304	Carbamoyl-Phosphate Synthase I Deficiency Disease	8.1%
305	Bronchopulmonary Dysplasia	7.9%
306	Niemann-Pick Disease, Type C	7.8%
307	Behcet Syndrome	7.4%
308	Talipes	7.4%
309	Familial Periodic Paralysis	7.1%
310	Lactose Intolerance	7%
311	Variegate Porphyria	7%
312	Acute intermittent porphyria	7%
313	Porphyria Cutanea Tarda	7%
314	Hyperhomocysteinemia	7%
315	Renal Aminoacidurias	7%
316	Fanconi Syndrome	7%
317	Pseudohypoaldosteronism	7%
318	Liddle Syndrome	7%
319	Denys-Drash Syndrome	7%
320	Hyperlipoproteinemia Type IV	7%
321	Hyperlipoproteinemia Type V	7%
322	Congenital clubfoot	6.9%
323	Vertical Talus	6.9%
324	Respiratory Distress Syndrome, Newborn	6.8%
325	Hypoalphalipoproteinemias	6.8%
326	Huntington Disease	6.6%
327	Ophthalmia Neonatorum	6.6%
328	Arteriovenous fistula	6.4%
329	Gout	6.2%
330	Multiple Endocrine Neoplasia Type 1	6.2%
331	Pseudohypoparathyroidism	6.2%
332	Friedreich Ataxia	6.1%
333	Renal tubular acidosis	6.1%
334	Nephroblastoma	6%
335	Hypokalemic periodic paralysis	5.8%
336	Cystinuria	5.8%
337	Leukomalacia, Periventricular	5.7%
338	Nesidioblastosis	5.6%
339	Adenomatous Polyposis Coli	5.4%
340	Familial Hypophosphatemic Rickets	5.3%
341	Arthritis, Gouty	5.1%
342	Hyaline Membrane Disease	5%
343	Glycosuria, Renal	4.9%
344	Kernicterus	4.5%
345	MELAS Syndrome	4%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234