MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Central Cord Syndrome

(UMLS:C0560651)

Definition:: A syndrome associated with traumatic injury to the cervical or upper thoracic regions of the spinal cord characterized by weakness in the arms with relative sparing of the legs and variable sensory loss. This condition is associated with ischemia, hemorrhage, or necrosis involving the central portions of the spinal cord. Corticospinal fibers destined for the legs are spared due to their more external location in the spinal cord. This clinical pattern may emerge during recovery from spinal shock. Deficits may be transient or permanent.
UMLS ID:: C0560651
MeSH ID:: D020210

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.854.763.500|C10.900.850.625

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.819.339

Synonym(s)

Central Cord Syndrome

Central cord syndrome

SPINAL CORD SYNDROME CENTRAL

central cord syndrome

central spinal cord syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Sildenafil Citrate	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Conus Medullaris Syndrome	33.3%
2	Autonomic Dysreflexia	28.6%
3	Myelitis	25.5%
4	Encephalomyelitis	23.1%
5	Stiff-Person Syndrome	22.9%
6	Epidural Abscess	22.3%
7	Pneumocephalus	21.9%
8	Spinal Muscular Atrophy	21.8%
9	Progressive Muscular Atrophy	21.8%
10	Peripheral Nerve Injuries	21.7%
11	Craniocerebral Trauma	21.4%
12	Syringomyelia	21%
13	Pneumorrhachis	21%
14	Meningoencephalitis	20.9%
15	Subacute Combined Degeneration	19.8%
16	Multiple System Atrophy	19.2%
17	Amyotrophic Lateral Sclerosis	19.2%
18	Brain Injuries	19%
19	Ocular Motility Disorders	18.9%
20	Cyclophoria	18.9%
21	Brain Diseases	17.9%
22	Meningitis	17.9%
23	Movement Disorders	17.9%
24	Pachymeningitis	17.9%
25	Spinal Cord Neoplasms	17.8%
26	Poliomyelitis	17.6%
27	Spinal Cord Vascular Diseases	17%
28	Cranial nerve diseases	16.8%
29	Demyelinating Diseases	16.8%
30	Demyelination	16.8%
31	Neuromuscular Diseases	16.8%
32	Chronobiology Disorders	16.8%
33	Prion Diseases	16.3%
34	Epilepsy, Post-Traumatic	16%
35	Brain Concussion	15.4%
36	Trauma, Nervous System	15.3%
37	Brain Hemorrhage, Traumatic	15.3%
38	Motor Neuron Disease	15.2%
39	Parkinson Disease	15%
40	Lewy Body Disease	15%
41	Central Nervous System Infection	14.9%
42	Subdural Effusion	14.7%
43	Parkinsonian Disorders	14.7%
44	Olfactory Nerve Injuries	14.2%
45	Frostbite	14.2%
46	Myelitis, Transverse	14.1%
47	Facial Injuries	14.1%
48	Dandy-Walker Syndrome	13.9%
49	Brain Injuries, Diffuse	13.7%
50	Traumatic Brain Injury	13.7%
51	Asterixis	13.6%
52	Ballismus	13.6%
53	Coma, Post-Head Injury	13.6%
54	Marchiafava-Bignami Disease	13.5%
55	Nervous System Neoplasms	13.5%
56	Neurologic Manifestations	13.5%
57	Neurotoxicity Syndromes	13.5%
58	Restless Legs Syndrome	13.2%
59	Striatonigral Degeneration	13.2%
60	Polyradiculoneuropathy	13.1%
61	Polyradiculoneuritis	13.1%
62	Progressive supranuclear palsy	12.9%
63	Carotid Artery Injuries	12.8%
64	Ophthalmoplegic Migraine	12.7%
65	Brain Abscess	12.5%
66	Facial Nerve Injuries	12.4%
67	Brain Contusion	12.4%
68	Complex Regional Pain Syndromes	12.2%
69	Meningitis, Bacterial	12.2%
70	Meningitis, Fungal	12.2%
71	Chronic Fatigue Syndrome	12.1%
72	Eye Burns	11.9%
73	Meige Syndrome	11.9%
74	Cerebral Ventriculitis	11.9%
75	Friedreich Ataxia	11.9%
76	Dystonia Musculorum Deformans	11.8%
77	Shy-Drager Syndrome	11.5%
78	Vertebral Artery Dissection	11.5%
79	MPTP Poisoning	11.4%
80	Sleep Wake Disorders	11.4%
81	Spinal Cord Ischemia	11.3%
82	Hip Fractures	11.3%
83	Neuroleptic Malignant Syndrome	11.2%
84	Myelinolysis, Central Pontine	11.2%
85	Diffuse Axonal Injury	11.2%
86	Leukoencephalopathy, Progressive Multifocal	11.1%
87	Brain Neoplasms	11.1%
88	Crush syndrome	11%
89	Femoral Fractures	11%
90	Tibial Fractures	11%
91	Leukoencephalitis, Acute Hemorrhagic	11%
92	Akinetic Mutism	10.9%
93	Anoxic Encephalopathy	10.9%
94	Arachnoiditis	10.9%
95	Basal Ganglia Diseases	10.9%
96	Brain Damage, Chronic	10.9%
97	Cerebellar Diseases	10.9%
98	Encephalitis	10.9%
99	Encephalomalacia	10.9%
100	Epilepsy	10.9%
101	Hydrocephalus	10.9%
102	Congenital Hydrocephalus	10.9%
103	Hypothalamic Diseases	10.9%
104	Aseptic Meningitis	10.9%
105	Thalamic Diseases	10.9%
106	Intracranial Hypertension	10.9%
107	Aura	10.9%
108	Leukoencephalopathy	10.9%
109	Essential Tremor	10.9%
110	Neuroaxonal Dystrophies	10.9%
111	Familial Tremor	10.9%
112	Headache Disorders	10.9%
113	Intracranial Hypotension	10.9%
114	Brain Edema	10.9%
115	Brain Hypoxia	10.9%
116	Aqueductal Stenosis	10.9%
117	Writer's Cramp	10.9%
118	Cerebrospinal Fluid Otorrhea	10.8%
119	Cerebrospinal Fluid Rhinorrhea	10.8%
120	Dementia, Vascular	10.8%
121	Lupus Vasculitis, Central Nervous System	10.7%
122	Opsoclonus-Myoclonus Syndrome	10.7%
123	Athletic Injuries	10.6%
124	Hand Injuries	10.6%
125	Soft Tissue Injuries	10.6%
126	Sprain	10.6%
127	Sprains and Strains	10.6%
128	Tendon Injuries	10.6%
129	Laceration	10.6%
130	Wounds, Penetrating	10.6%
131	Heat Cramps	10.6%
132	Rupture	10.6%
133	Huntington Disease	10.6%
134	Posterior Leukoencephalopathy Syndrome	10.6%
135	Posterior reversible encephalopathy syndrome	10.6%
136	Guillain-Barre Syndrome	10.4%
137	Limbic Encephalitis	10.3%
138	Miller Fisher Syndrome	10.3%
139	Myasthenia Gravis	10.2%
140	Akathisia, Drug-Induced	10.1%
141	Dyskinesia, Drug-Induced	10.1%
142	Creutzfeldt-Jakob disease	9.9%
143	Basal Ganglia Cerebrovascular Disease	9.9%
144	Encephalomyelitis, Acute Disseminated	9.9%
145	Chilblains	9.5%
146	Spinal Fractures	9.5%
147	Dysautonomia	9.4%
148	Vagus Nerve Disorder	9.4%
149	Glossopharyngeal Neuralgia	9.4%
150	Abducens Nerve Diseases	9.4%
151	Heavy Metal Poisoning, Nervous System	9.4%
152	Neuromuscular Junction Diseases	9.4%
153	Tauopathies	9.4%
154	Trochlear Nerve Diseases	9.4%
155	Peripheral Nervous System Diseases	9.4%
156	Progressive bulbar palsy	9.4%
157	Bulbar palsy	9.4%
158	Causalgia	9.4%
159	Tuberculosis, Meningeal	9.4%
160	Lambert-Eaton Myasthenic Syndrome	9.3%
161	Cerebellar Neoplasms	9.3%
162	Myoclonic Epilepsy	9.2%
163	Epilepsy, Temporal Lobe	9.2%
164	Epilepsy, Rolandic	9.2%
165	Benign Rolandic Epilepsy	9.2%
166	Eye Injuries	9.1%
167	Hip Dislocation	9.1%
168	Shoulder Dislocation	9.1%
169	Splenic Rupture	9.1%
170	Hip Dysplasia	9.1%
171	Brain Death	9.1%
172	Subarachnoid Hemorrhage, Traumatic	9.1%
173	Carotid Artery, Internal, Dissection	9.1%
174	Scrapie	9%
175	Sleep Disorders, Circadian Rhythm	9%
176	Presenile dementia	8.9%
177	Senile dementia	8.9%
178	Brain Diseases, Metabolic	8.8%
179	Cerebrovascular Disorders	8.8%
180	Cerebrovascular Insufficiency	8.8%
181	Dementia	8.8%
182	Central Nervous System Fungal Infections	8.8%
183	Chorea	8.8%
184	Vascular Headaches	8.8%
185	Hypoxia-Ischemia, Brain	8.8%
186	Neuromyelitis Optica	8.7%
187	Botulism	8.7%
188	Central Nervous System Cysts	8.7%
189	Amblyopia	8.6%
190	Anterior Spinal Artery Syndrome	8.6%
191	Medial Tibial Stress Syndrome	8.6%
192	Leukomalacia, Periventricular	8.5%
193	Bites and Stings	8.5%
194	Extravasation of Diagnostic and Therapeutic Materials	8.5%
195	Vascular System Injuries	8.5%
196	Tympanic Membrane Perforation	8.5%
197	Tooth Injuries	8.5%
198	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	8.5%
199	Hepatolenticular Degeneration	8.5%
200	Lafora Disease	8.5%
201	Unverricht-Lundborg Syndrome	8.5%
202	Vasculitis, Central Nervous System	8.4%
203	Asphyxia	8.4%
204	Esophageal Perforation	8.4%
205	Shock, Traumatic	8.4%
206	Self Mutilation	8.3%
207	Carpal Tunnel Syndrome	8.3%
208	Toxoplasmosis, Cerebral	8.2%
209	Iliotibial Band Syndrome	8.1%
210	Canavan Disease	8%
211	Alexander Disease	8%
212	Reflex Sympathetic Dystrophy	8%
213	Nocturnal Myoclonus Syndrome	8%
214	Hematoma, Subdural	8%
215	Hematoma, Epidural, Cranial	8%
216	Juvenile Myoclonic Epilepsy	7.9%
217	Myoclonic Epilepsies, Progressive	7.9%
218	Myopathy	7.8%
219	Optic Neuropathy	7.8%
220	Multiple Sclerosis	7.8%
221	Cerebellar Ataxia	7.7%
222	Supratentorial Neoplasms	7.7%
223	Torticollis	7.7%
224	Horner Syndrome	7.6%
225	Facial Nerve Diseases	7.6%
226	Parasomnia	7.6%
227	Dyssomnias	7.6%
228	Paraneoplastic Cerebellar Degeneration	7.6%
229	Meningitis, Cryptococcal	7.5%
230	Cerebral Palsy	7.5%
231	Epilepsies, Partial	7.5%
232	Epilepsy, Generalized	7.5%
233	Pseudotumor Cerebri	7.5%
234	Hypertensive Encephalopathy	7.5%
235	Simple Partial Seizures	7.5%
236	Epilepsy, Reflex	7.5%
237	Headache Disorders, Primary	7.5%
238	Headache Disorders, Secondary	7.5%
239	Medication overuse headache	7.5%
240	Meningitis, Listeria	7.5%
241	Vestibulocochlear Nerve Diseases	7.5%
242	Decerebrate State	7.5%
243	Hemiparesis	7.5%
244	Hydranencephaly	7.5%
245	Meningism	7.5%
246	Neural Tube Defects	7.5%
247	Paresis	7.5%
248	Seizures	7.5%
249	Sensation Disorders	7.5%
250	Tethered Cord Syndrome	7.5%
251	Central Nervous System Neoplasms	7.5%
252	Complex partial seizures	7.5%
253	Iniencephaly	7.5%
254	Craniorachischisis	7.5%
255	Exencephaly	7.5%
256	Monoparesis	7.5%
257	Septo-Optic Dysplasia	7.5%
258	Cortical Dysplasia	7.5%
259	Neurogenic Inflammation	7.5%
260	Gait Disorders, Neurologic	7.5%
261	Neuromuscular Manifestations	7.5%
262	Malformations of Cortical Development	7.5%
263	Meningitis, Haemophilus	7.5%
264	Meningitis, Pneumococcal	7.5%
265	Sweating, Gustatory	7.4%
266	Auriculotemporal Syndrome	7.4%
267	Central Nervous System Bacterial Infections	7.4%
268	Basal Ganglia Hemorrhage	7.2%
269	Cubital Tunnel Syndrome	7.1%
270	Persistent Vegetative State	7.1%
271	Pituitary Adenoma	7%
272	Pituitary Neoplasms	7%
273	Amnesia, Transient Global	7%
274	Myasthenia Gravis, Autoimmune, Experimental	7%
275	Drowning	6.9%
276	Ataxia Telangiectasia	6.9%
277	Human Bite	6.8%
278	Contusions	6.8%
279	Decompression Sickness	6.8%
280	Finger Injuries	6.8%
281	Flail Chest	6.8%
282	Fractures, Closed	6.8%
283	Pathological fracture	6.8%
284	Heart Injuries	6.8%
285	Heat Exhaustion	6.8%
286	Heat Stroke	6.8%
287	Knee Injuries	6.8%
288	Foot Injuries	6.8%
289	Decapitation	6.8%
290	Ankle Fracture	6.8%
291	Avulsion fracture	6.8%
292	Compression fracture	6.8%
293	Osteoporotic Fractures	6.8%
294	Hematoma, Subdural, Intracranial	6.8%
295	Hematoma, Subdural, Chronic	6.8%
296	Hematoma, Subdural, Acute	6.8%
297	Ophthalmoplegia	6.7%
298	External Ophthalmoplegia	6.7%
299	Jet Lag Syndrome	6.7%
300	Splenosis	6.7%
301	Pituitary Apoplexy	6.6%
302	Subacute Sclerosing Panencephalitis	6.6%
303	Brachial Plexus Neuritis	6.6%
304	Neuralgic Amyotrophy	6.6%
305	Acrodynia	6.6%
306	Charcot-Marie-Tooth Disease	6.6%
307	Tardive Dyskinesia	6.6%
308	Brain Infarction	6.5%
309	Tuberous Sclerosis	6.5%
310	Corneal Scar	6.5%
311	Pupil Disorders	6.4%
312	Neurobehavioral Manifestations	6.4%
313	Paraneoplastic Encephalomyelitis	6.3%
314	Putaminal Hemorrhage	6.3%
315	Pituitary Diseases	6.2%
316	Uveomeningoencephalitic Syndrome	6.2%
317	Sturge-Weber Syndrome	6.2%
318	Vertigo	6.2%
319	Alcohol-Induced Disorders, Nervous System	6.2%
320	Infarction, Middle Cerebral Artery	6.1%
321	Infarction, Anterior Cerebral Artery	6.1%
322	Infarction, Posterior Cerebral Artery	6.1%
323	Carotid Artery Diseases	6%
324	Brain Ischemia	6%
325	Cerebrovascular accident	6%
326	Kluver-Bucy Syndrome	6%
327	Vasospasm, Intracranial	6%
328	Intracranial Arterial Diseases	6%
329	Brain Stem Neoplasms	6%
330	Tarsal Tunnel Syndrome	5.9%
331	Cauda Equina Syndrome	5.9%
332	Vocal Cord Paralysis	5.9%
333	Tuberculosis, Central Nervous System	5.9%
334	Neuritis	5.9%
335	Polyneuritis	5.9%
336	Radiculitis	5.9%
337	Polyneuropathy	5.9%
338	Mononeuritis	5.9%
339	Mononeuropathies	5.9%
340	Brachial Plexus Neuropathies	5.9%
341	Radiculopathy	5.9%
342	Mononeuropathy Multiplex	5.9%
343	Nerve Root Compression	5.9%
344	Radiation injury	5.8%
345	Post-Traumatic Headache	5.8%
346	Tension Headache	5.8%
347	Epilepsy, Complex Partial	5.8%
348	Migraine Disorders	5.8%
349	Abdominal Migraine	5.8%
350	Status Migrainosus	5.8%
351	Cervicogenic Headache	5.8%
352	Alice in Wonderland Syndrome	5.8%
353	Mitochondrial Encephalomyopathies	5.8%
354	Corneal Perforation	5.8%
355	Myotonia Congenita	5.7%
356	Neuritis, Autoimmune, Experimental	5.7%
357	Gait Ataxia	5.6%
358	Frontotemporal dementia	5.6%
359	Cerebral Infarction	5.6%
360	Brain Stem Infarctions	5.6%
361	Tendinitis	5.5%
362	Lung Injury	5.5%
363	Tendinopathy	5.5%
364	Multiple Sclerosis, Chronic Progressive	5.5%
365	Multiple Sclerosis, Relapsing-Remitting	5.5%
366	Foreign-Body Reaction	5.4%
367	Insect Bites and Stings	5.4%
368	Paralysis, Obstetric	5.4%
369	Sunburn	5.4%
370	Tooth Avulsion	5.4%
371	Voice Disorders	5.4%
372	Voice Disturbance	5.4%
373	Near Drowning	5.4%
374	Osteoradionecrosis	5.4%
375	Refsum Disease	5.3%
376	Smith-Magenis syndrome	5.3%
377	Moyamoya Disease	5.3%
378	Myotonic Dystrophy	5.3%
379	Dural Arteriovenous Fistula	5.3%
380	Adrenoleukodystrophy	5.3%
381	Spinal Cord Injuries	5.3%
382	West Nile Fever	5.2%
383	Choroid Plexus Papilloma	5.2%
384	Alcohol Withdrawal Seizures	5.1%
385	Spinal Cord Diseases	5.1%
386	Auditory Perceptual Disorders	5.1%
387	Lateral Medullary Syndrome	5.1%
388	Pseudarthrosis	5%
389	Smoke Inhalation Injury	5%
390	Reye Syndrome	5%
391	Neuroaspergillosis	5%
392	Intracranial Embolism and Thrombosis	5%
393	Hepatic Encephalopathy	5%
394	Cluster Headache	5%
395	Migraine with Aura	5%
396	Familial Hemiplegic Migraine	5%
397	Chronic Paroxysmal Hemicrania	5%
398	SUNCT Syndrome	5%
399	Paroxysmal Hemicrania	5%
400	Akathisia	4.9%
401	Restlessness	4.9%
402	Psychomotor Agitation	4.9%
403	neurofibroma	4.9%
404	Sciatica	4.9%
405	MELAS Syndrome	4.9%
406	Myositis	4.8%
407	Optic Atrophy	4.8%
408	Optic Neuritis	4.8%
409	Papilledema	4.8%
410	Strabismus	4.8%
411	Tolosa-Hunt Syndrome	4.8%
412	Isaacs syndrome	4.8%
413	Arsenic Poisoning	4.8%
414	Myotonic Disorders	4.8%
415	Myasthenic Syndromes, Congenital	4.8%
416	Optic Nerve Glioma	4.7%
417	Empty Sella Syndrome	4.7%
418	Hyperpituitarism	4.7%
419	Hypopituitarism	4.7%
420	Hypophysitis	4.7%
421	Diabetic Neuropathies	4.7%
422	Facial Neuralgia	4.7%
423	Diabetic Amyotrophy	4.7%
424	Diabetic Autonomic Neuropathy	4.7%
425	Sleep Talking	4.7%
426	Manganese Poisoning	4.7%
427	Sleep Disorders, Intrinsic	4.7%
428	Orthostatic intolerance	4.7%
429	Anosmia	4.7%
430	Ataxia	4.7%
431	Athetosis	4.7%
432	Catalepsy	4.7%
433	Dystonia	4.7%
434	Hemiplegia	4.7%
435	Locked-In Syndrome	4.7%
436	Meningeal Neoplasms	4.7%
437	Meningomyelocele	4.7%
438	Muscle Hypertonia	4.7%
439	Muscle hypotonia	4.7%
440	Myoclonus	4.7%
441	Myotonia	4.7%
442	Neuralgia	4.7%
443	Paraplegia	4.7%
444	Pseudobulbar Palsy	4.7%
445	Quadriplegia	4.7%
446	Spasm	4.7%
447	Spastic Paraplegia	4.7%
448	Status Epilepticus	4.7%
449	Taste Disorders	4.7%
450	Tremor	4.7%
451	Spina Bifida	4.7%
452	Monoplegia	4.7%
453	Hypokinesia	4.7%
454	Paraparesis	4.7%
455	Bradykinesia	4.7%
456	Waxy flexibility	4.7%
457	Action Tremor	4.7%
458	Resting Tremor	4.7%
459	Dysosmia	4.7%
460	Quadriparesis	4.7%
461	Mercury Poisoning, Nervous System	4.7%
462	Olfaction Disorders	4.7%
463	Myokymia	4.7%
464	Lead Poisoning, Nervous System	4.7%
465	Vestibular Neuronitis	4.7%
466	Somatosensory Disorders	4.7%
467	Neuropathic pain	4.7%
468	Hyperkinesia	4.7%
469	Intention tremor	4.7%
470	Neoplasms, Radiation-Induced	4.7%
471	Cerebral Arterial Diseases	4.6%
472	Vertebrobasilar Insufficiency	4.6%
473	Basilar Artery Stenosis	4.6%
474	Vertebral Artery Stenosis	4.6%
475	Intracranial Hemorrhage, Hypertensive	4.6%
476	Transient Cerebral Ischemia	4.6%
477	Giant Cell Arteritis	4.6%
478	Temporal Arteritis	4.6%
479	Reflex, Abnormal	4.6%
480	Hyporeflexia	4.6%
481	Hyperreflexia	4.6%
482	Gait Apraxia	4.5%
483	Uterine Rupture	4.5%
484	Pseudorabies	4.5%
485	Alstrom Syndrome	4.4%
486	Brain Diseases, Metabolic, Inborn	4.3%
487	Neurosyphilis	4.2%
488	Sciatic Neuropathy	4.2%
489	Ulnar Neuropathies	4.2%
490	Lesion of Sciatic Nerve	4.2%
491	Ulnar Neuritis	4.2%
492	Radial nerve compression	4.2%
493	Radial Tunnel Syndrome	4.2%
494	Peroneal Neuropathies	4.2%
495	Radial Neuropathy	4.2%
496	Median Neuropathy	4.2%
497	Sciatic Nerve Palsy	4.2%
498	Femoral Neuropathy	4.2%
499	Tibial Neuropathy	4.2%
500	Ulnar Nerve Palsy	4.2%
501	Postural Orthostatic Tachycardia Syndrome	4.2%
502	Radial nerve palsy	4.2%
503	Hand-Arm Vibration Syndrome	4.1%
504	Granuloma, Foreign-Body	4%
505	Enthesopathy	4%
506	Vision Disorders	4%
507	Metamorphopsia	4%
508	Visual Impairment	4%
509	Fibromyalgia	4%
510	Optic Neuropathy, Ischemic	4%
511	Anterior Ischemic Optic Neuropathy	4%
512	Uterine Perforation	4%
513	Hyperprolactinemia	4%
514	Facial Hemiatrophy	4%
515	Melkersson-Rosenthal Syndrome	4%
516	Mitochondrial Myopathies	4%
517	Subclavian Steal Syndrome	3.9%
518	Pick Disease of the Brain	3.9%
519	Amyloid Neuropathies, Familial	3.9%
520	Anisocoria	3.9%
521	Confusion	3.9%
522	Facial paralysis	3.9%
523	Lethargy	3.9%
524	Memory Disorders	3.9%
525	Muscle Cramp	3.9%
526	Perceptual Disorders	3.9%
527	Psychomotor Disorders	3.9%
528	Tonic Pupil	3.9%
529	Eosinophilia-Myalgia Syndrome	3.9%
530	Anhedonia	3.9%
531	Disorientation	3.9%
532	Facial Paresis	3.9%
533	Memory Loss	3.9%
534	Hemisensory Neglect	3.9%
535	Dysacusis	3.9%
536	Cardiotoxicity	3.9%
537	Sleep Bruxism	3.9%
538	Toxoplasmosis, Congenital	3.9%
539	Anencephaly	3.9%
540	Meningocele	3.9%
541	Muscular Atrophy	3.9%
542	Respiratory Paralysis	3.9%
543	Encephalocele	3.9%
544	Leukemia, Radiation-Induced	3.9%
545	Malaria, Cerebral	3.9%
546	Tetany	3.9%
547	Carotid Stenosis	3.9%
548	Intracranial Aneurysm	3.9%
549	Radiation Pneumonitis	3.8%
550	Neurocysticercosis	3.8%
551	Radiation Fibrosis	3.8%
552	Intracranial Arteriosclerosis	3.8%
553	Cerebral Atherosclerosis	3.8%
554	Subarachnoid Hemorrhage	3.8%
555	Cerebral Arteriosclerosis	3.8%
556	Cerebral Hemorrhage	3.8%
557	Acoustic Neuroma	3.8%
558	Cerebral Thrombosis	3.8%
559	Intracranial Embolism	3.8%
560	Intracranial Thrombosis	3.8%
561	Aortic Rupture	3.8%
562	Wernicke Encephalopathy	3.7%
563	AIDS Dementia Complex	3.7%
564	Lyme Neuroborreliosis	3.7%
565	Classical Lissencephalies and Subcortical Band Heterotopias	3.7%
566	Waterhouse-Friderichsen Syndrome	3.5%
567	Duane Retraction Syndrome	3.4%
568	Consciousness Disorders	3.4%
569	Mental Retardation	3.4%
570	Muscle Weakness	3.4%
571	Depressed Level of Consciousness	3.4%
572	Mental deficiency	3.4%
573	Intellectual Disability	3.4%
574	Mobius Syndrome	3.4%
575	Bell Palsy	3.4%
576	Thoracic Outlet Syndrome	3.4%
577	Central Cord Syndrome	3.4%
578	Catatonia	3.4%
579	Kernicterus	3.4%
580	Herpes Zoster Oticus	3.4%
581	Familial Periodic Paralysis	3.3%
582	Abnormalities, Radiation-Induced	3.3%
583	Aphonia	3.3%
584	Esotropia	3.3%
585	Exotropia	3.3%
586	Hypotension, Orthostatic	3.3%
587	Sleep Apnea Syndromes	3.3%
588	Sleep Deprivation	3.3%
589	Polymyositis	3.3%
590	Dysphonia	3.3%
591	Post-Exercise Hypotension	3.3%
592	Acromegaly	3.3%
593	Polyradiculopathy	3.3%
594	Radiation Injuries, Experimental	3.3%
595	Disorders of Excessive Somnolence	3.3%
596	Sleep Initiation and Maintenance Disorders	3.3%
597	Night Terrors	3.3%
598	Somnambulism	3.3%
599	Trigeminal Nerve Disorder	3.3%
600	Transient Insomnia	3.3%
601	Sleep Paralysis	3.3%
602	Chronic Insomnia	3.3%
603	REM Sleep Behavior Disorder	3.3%
604	Hypersomnia	3.3%
605	Dermal Sinus	3.3%
606	Dysgeusia	3.3%
607	Formication	3.3%
608	Hyperalgesia	3.3%
609	Hyperesthesia	3.3%
610	Hypesthesia	3.3%
611	Language Disorders	3.3%
612	Numbness	3.3%
613	Paresthesia	3.3%
614	Paraparesis, Spastic	3.3%
615	Spina Bifida Cystica	3.3%
616	Trismus	3.3%
617	Spina Bifida Occulta	3.3%
618	Epilepsia Partialis Continua	3.3%
619	Hypogeusia	3.3%
620	Meningeal Carcinomatosis	3.3%
621	Brown-Sequard Syndrome	3.3%
622	Lissencephaly	3.3%
623	Polymicrogyria	3.3%
624	Pachygyria	3.3%
625	Schizencephaly	3.3%
626	Lockjaw	3.3%
627	Allodynia	3.3%
628	Lead Poisoning, Nervous System, Childhood	3.3%
629	Lead Poisoning, Nervous System, Adult	3.3%
630	Periventricular Nodular Heterotopia	3.3%
631	Ageusia	3.3%
632	Cerebral Amyloid Angiopathy	3.3%
633	Carotid Artery Thrombosis	3.3%
634	Sinus Thrombosis, Intracranial	3.3%
635	Alexia	3.3%
636	Dyslexia	3.3%
637	Neurofibrosarcoma	3%
638	Kearns-Sayre syndrome	3%
639	Cavernous Sinus Thrombosis	3%
640	Sagittal Sinus Thrombosis	3%
641	Optic Atrophy, Hereditary, Leber	3%
642	Myalgia	2.9%
643	Neuronal Ceroid-Lipofuscinoses	2.9%
644	Muscular Dystrophy	2.8%
645	Congenital nystagmus	2.8%
646	Orbital Myositis	2.8%
647	Diplopia	2.8%
648	Muscle Rigidity	2.8%
649	Muscle Spasticity	2.8%
650	Scotoma	2.8%
651	Photophobia	2.8%
652	Cogwheel Rigidity	2.8%
653	Hemifacial Spasm	2.8%
654	Amaurosis	2.8%
655	Blindness	2.8%
656	Nuchal Rigidity	2.8%
657	Pyomyositis	2.8%
658	Menkes Kinky Hair Syndrome	2.8%
659	Agnosia	2.8%
660	Apraxias	2.8%
661	Hallucinations	2.8%
662	Hemianopsia	2.8%
663	Hyperacusis	2.8%
664	Tinnitus	2.8%
665	Visual Agnosia	2.8%
666	Anosognosia	2.8%
667	Wernicke-Korsakoff Syndrome	2.8%
668	Phonophobia	2.8%
669	Hearing Loss	2.8%
670	Sarcopenia	2.7%
671	Fabry Disease	2.7%
672	Sleep Apnea, Obstructive	2.6%
673	Sleep Apnea, Central	2.6%
674	Narcolepsy	2.6%
675	Trigeminal Neuralgia	2.6%
676	Aicardi's syndrome	2.6%
677	Kleine-Levin Syndrome	2.6%
678	Agraphia	2.6%
679	Anomia	2.6%
680	Cluttering	2.6%
681	Language Development Disorders	2.6%
682	Speech Disorders	2.6%
683	Syncope	2.6%
684	Stupor	2.6%
685	Dysgraphia	2.6%
686	Presyncope	2.6%
687	Dyslalia	2.6%
688	Hoarseness	2.6%
689	Cockayne Syndrome	2.6%
690	Alcohol Withdrawal Delirium	2.6%
691	Nelson Syndrome	2.6%
692	Galactosemias	2.5%
693	Urea Cycle Disorders, Inborn	2.5%
694	Tyrosinemias	2.5%
695	Prolactinoma	2.5%
696	Growth Hormone-Secreting Pituitary Adenoma	2.5%
697	Amnesia	2.4%
698	Delirium	2.4%
699	Dissociative Amnesia	2.4%
700	Color blindness	2.4%
701	Global Amnesia	2.4%
702	Cri-du-Chat Syndrome	2.4%
703	Down Syndrome	2.4%
704	Trisomy 21	2.4%
705	POEMS Syndrome	2.4%
706	Meningioma	2.4%
707	Williams Syndrome	2.4%
708	Microcephaly	2.4%
709	Macrocephaly	2.4%
710	Hypokalemic periodic paralysis	2.3%
711	Porencephaly	2.3%
712	Holoprosencephaly	2.3%
713	Homocystinuria	2.3%
714	Cataplexy	2.3%
715	Aphasia	2.3%
716	Articulation Disorders	2.3%
717	Echolalia	2.3%
718	Stuttering	2.3%
719	Dysphasia	2.3%
720	Leigh Disease	2.3%
721	Welander Distal Myopathy	2.2%
722	Amaurosis Fugax	2.2%
723	Blindness, Cortical	2.2%
724	Dyscalculia	2.2%
725	Rett Syndrome	2.2%
726	Deafness	2.2%
727	Hearing Loss, Sudden	2.2%
728	Gerstmann Syndrome	2.2%
729	Hearing Loss, Bilateral	2.2%
730	Hearing Loss, High-Frequency	2.2%
731	Hearing Loss, Mixed Conductive-Sensorineural	2.2%
732	Prosopagnosia	2.2%
733	Apraxia, Ideomotor	2.2%
734	Charles Bonnet Syndrome	2.2%
735	Hearing Loss, Unilateral	2.2%
736	Complete Hearing Loss	2.2%
737	Alien Hand Syndrome	2.2%
738	Deaf Mutism	2.2%
739	Dysarthria	2.1%
740	Prader-Willi Syndrome	2.1%
741	Phantom pain	2%
742	Phantom Limb Pain	2%
743	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.9%
744	Mutism	1.9%
745	Selective Mutism	1.9%
746	Dermatomyositis	1.9%
747	Muscular Dystrophy, Duchenne	1.9%
748	Retrograde amnesia	1.9%
749	Amnesia, Anterograde	1.9%
750	Alexia, Pure	1.8%
751	Zellweger Syndrome	1.8%
752	Glycogen storage disease type II	1.8%
753	Rubinstein-Taybi Syndrome	1.7%
754	Fragile X Syndrome	1.6%
755	Gaucher Disease	1.5%
756	Tay-Sachs Disease	1.4%
757	Niemann-Pick Disease, Type C	1.3%
758	Mucopolysaccharidosis II	1.2%

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