MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Aicardi's syndrome

(UMLS:C0175713)

Definition:: A rare genetic disorder characterized by partial or complete absence of the CORPUS CALLOSUM, resulting in infantile spasms, MENTAL RETARDATION, and lesions of the RETINA or OPTIC NERVE.
UMLS ID:: C0175713
MeSH ID:: D058540

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.034.687

Classification 2:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.270.019

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.162|C16.131.666.034.687|C16.320.290.019|C16.320.322.030

Synonym(s)

Aicardi's syndrome

AIC - Aicardi syndrome

AICARDI SYNDROME

Aicardi Syndrome

Aicardi syndrome

Microphthalmia, seizure, hypsarrhythmia syndrome

aicardi syndrome

aicardi's syndrome

chorioretinal anomalies-corpus callosum agenesis-infantile spasms syndrome

10.

corpus callosum agenesis-chorioretinal abnormality syndrome

11.

corpus callosum agenesis-chorioretinopathy-infantile spasms syndrome

12.

corpus callosum agenesis-ocular anomalies-salaam seizures syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fentanyl	FAERS: 1		US FAERS
2	Ruxolitinib phosphate	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Holoprosencephaly	53.7%
2	Alstrom Syndrome	42.4%
3	Retinal Dysplasia	38.6%
4	Beckwith-Wiedemann Syndrome	38.6%
5	Wolf-Hirschhorn Syndrome	38.6%
6	CHARGE Syndrome	38.5%
7	Aniridia	37.8%
8	Smith-Magenis syndrome	36.9%
9	Cri-du-Chat Syndrome	35.6%
10	Down Syndrome	35.6%
11	Trisomy 21	35.6%
12	Fragile X Syndrome	35%
13	Rubinstein-Taybi Syndrome	34.1%
14	Kartagener Syndrome	34%
15	Albinism	33.8%
16	Ichthyosis, X-Linked	33.4%
17	Classical Lissencephalies and Subcortical Band Heterotopias	32.5%
18	Prader-Willi Syndrome	32.2%
19	Ectodermal Dysplasia	31.5%
20	Aplasia Cutis Congenita	31.5%
21	Dural Arteriovenous Fistula	31.1%
22	Anencephaly	30.6%
23	Cockayne Syndrome	29.3%
24	Retinitis Pigmentosa	29.3%
25	Pigmentary retinopathy	29.3%
26	Duane Retraction Syndrome	29%
27	Marfan Syndrome	28.9%
28	Nail-Patella Syndrome	28.7%
29	Muscular Dystrophy, Duchenne	28.2%
30	Hydranencephaly	27.7%
31	Neural Tube Defects	27.7%
32	Tethered Cord Syndrome	27.7%
33	Iniencephaly	27.7%
34	Craniorachischisis	27.7%
35	Exencephaly	27.7%
36	Septo-Optic Dysplasia	27.7%
37	Cortical Dysplasia	27.7%
38	Malformations of Cortical Development	27.7%
39	Eye Abnormalities	27.5%
40	Tuberous Sclerosis	25.8%
41	Cystic Fibrosis	25.6%
42	Aicardi's syndrome	25.4%
43	Refsum Disease	25.1%
44	Mucopolysaccharidosis II	24.9%
45	Abnormalities, Drug-Induced	24.9%
46	Situs Inversus	24.9%
47	Menkes Kinky Hair Syndrome	24%
48	Dandy-Walker Syndrome	23.9%
49	Rett Syndrome	23.8%
50	Williams Syndrome	23.7%
51	Smith-Lemli-Opitz Syndrome	23.5%
52	Charcot-Marie-Tooth Disease	23.4%
53	Central Nervous System Cysts	23.3%
54	Optic Atrophy, Hereditary, Leber	23.1%
55	Wiskott-Aldrich Syndrome	22.8%
56	Polycystic Kidney Diseases	22.7%
57	Myasthenic Syndromes, Congenital	22.6%
58	Cardiovascular Abnormalities	22.3%
59	Anemia, Sickle Cell	22.1%
60	Thalassemia	22.1%
61	Skin Abnormalities	21.9%
62	Lymphatic Abnormalities	21.9%
63	Congenital Microtia	21.9%
64	Adrenoleukodystrophy	21.7%
65	Mobius Syndrome	21.7%
66	Microcephaly	21.6%
67	Macrocephaly	21.6%
68	Congenital diaphragmatic hernia	21.6%
69	Sjogren-Larsson Syndrome	21.6%
70	Neoplastic Syndromes, Hereditary	21.4%
71	Primary Ciliary Dyskinesia	21%
72	Maxillofacial Abnormalities	20.9%
73	Multiple Epiphyseal Dysplasia	20.9%
74	Osteochondrodysplasias	20.9%
75	Pelger-Huet Anomaly	20.9%
76	Werner Syndrome	20.9%
77	Dextrocardia	20.8%
78	Epidermolysis Bullosa	20.8%
79	Xeroderma	20.3%
80	Porencephaly	20.2%
81	Turner Syndrome	20.1%
82	Kallmann Syndrome	20%
83	Fabry Disease	19.9%
84	Urogenital Abnormalities	19.8%
85	Meningomyelocele	19.7%
86	Spina Bifida	19.7%
87	Muscular Dystrophy	19.5%
88	Blepharophimosis	19.4%
89	Myotonic Dystrophy	19.3%
90	Dwarfism	18.9%
91	Hepatolenticular Degeneration	18.8%
92	Acrocephalosyndactylia	18.8%
93	Osteogenesis Imperfecta	18.4%
94	Anophthalmos	18.3%
95	Microphthalmos	18.3%
96	Chronic granulomatous disease	18.3%
97	Zellweger Syndrome	18.1%
98	Fetal Diseases	17.9%
99	Pseudoxanthoma Elasticum	17.6%
100	Scimitar Syndrome	17.6%
101	Meningocele	17.5%
102	Encephalocele	17.5%
103	Neuronal Ceroid-Lipofuscinoses	17.5%
104	Polycystic Kidney, Autosomal Dominant	17.2%
105	Klinefelter Syndrome	17%
106	Prune Belly Syndrome	16.9%
107	Twins, Conjoined	16.9%
108	Waardenburg Syndrome	16.9%
109	Hyperkeratosis, Epidermolytic	16.7%
110	Autoimmune Lymphoproliferative Syndrome	16.7%
111	Sickle Cell Trait	16.6%
112	Amyloid Neuropathies, Familial	16.5%
113	Angioedemas, Hereditary	16.4%
114	Xeroderma Pigmentosum	16.4%
115	Craniosynostosis	16.3%
116	Syndactyly	16.3%
117	Brachycephaly	16.3%
118	Familial Mediterranean Fever	15.9%
119	Dermal Sinus	15.9%
120	Spina Bifida Cystica	15.9%
121	Spina Bifida Occulta	15.9%
122	Lissencephaly	15.9%
123	Polymicrogyria	15.9%
124	Pachygyria	15.9%
125	Schizencephaly	15.9%
126	Periventricular Nodular Heterotopia	15.9%
127	Canavan Disease	15.7%
128	Alexander Disease	15.7%
129	Antley-Bixler Syndrome Phenotype	15.7%
130	Cleft Palate	15.6%
131	Abnormalities, Radiation-Induced	15.6%
132	Meconium Aspiration Syndrome	15.6%
133	Ataxia Telangiectasia	15.5%
134	Glycogen storage disease type II	15.2%
135	Noonan Syndrome	15.1%
136	Basal Cell Nevus Syndrome	15.1%
137	Anus, Imperforate	14.9%
138	Limb Deformities, Congenital	14.9%
139	Craniofacial Abnormalities	14.9%
140	Anorectal Malformations	14.9%
141	Bloom Syndrome	14.8%
142	Galactosemias	14.4%
143	Urea Cycle Disorders, Inborn	14.4%
144	Tyrosinemias	14.4%
145	Dystonia Musculorum Deformans	14.4%
146	Jaw Abnormalities	14%
147	Acute Chest Syndrome	14%
148	Amino Acid Metabolism, Inborn Errors	13.9%
149	Carbohydrate Metabolism, Inborn Errors	13.9%
150	Metal Metabolism, Inborn Errors	13.9%
151	Progeria	13.9%
152	Lysosomal Storage Diseases	13.9%
153	Cytochrome-c Oxidase Deficiency	13.9%
154	Peroxisomal Disorders	13.9%
155	Poland Syndrome	13.8%
156	Retinal Degeneration	13.7%
157	Lafora Disease	13.7%
158	Unverricht-Lundborg Syndrome	13.7%
159	Mandibulofacial Dysostosis	13.6%
160	Myotonia Congenita	13.4%
161	Laryngostenosis	13.3%
162	Mouth Abnormalities	13.3%
163	Esophageal Atresia	13.2%
164	Intestinal Atresia	13.2%
165	Horseshoe Kidney	13.2%
166	Pectus excavatum	13.2%
167	Welander Distal Myopathy	13.2%
168	Klippel-Feil Syndrome	13.2%
169	Gastroschisis	13.2%
170	Synostosis	13.2%
171	Acrodermatitis	13.1%
172	Lymphangiectasis, Intestinal	13.1%
173	Gianotti-Crosti Syndrome	13.1%
174	Congenital nystagmus	12.8%
175	Gaucher Disease	12.8%
176	POEMS Syndrome	12.7%
177	Hyperphosphaturia	12.7%
178	Mucopolysaccharidosis III	12.6%
179	Cutis Laxa	12.5%
180	Porokeratosis	12.4%
181	Keratoderma, Palmoplantar	12.4%
182	Homocystinuria	12.4%
183	Leigh Disease	12.3%
184	Abdominal Cramps	12.2%
185	Amniotic Band Syndrome	12.2%
186	Asphyxia Neonatorum	12.2%
187	Infant, Premature, Diseases	12.2%
188	Infantile Colic	12.2%
189	Micrognathism	12.1%
190	Pierre Robin Syndrome	12.1%
191	Brain Diseases, Metabolic, Inborn	12.1%
192	Arthrogryposis	12%
193	Choanal Atresia	12%
194	Tracheobronchomegaly	12%
195	Laryngocele	12%
196	Choledochal Cyst	11.9%
197	Hermaphroditism	11.9%
198	Disorders of Sex Development	11.9%
199	Cryptorchidism	11.9%
200	Hypospadias	11.9%
201	Tay-Sachs Disease	11.7%
202	Huntington Disease	11.7%
203	Amelia	11.3%
204	Arachnodactyly	11.3%
205	Ectopia Cordis	11.3%
206	Ectromelia	11.3%
207	Hemimelia	11.3%
208	Phocomelia	11.3%
209	Sirenomelia	11.3%
210	Polydactyly	11.3%
211	Brachydactyly	11.3%
212	Plagiocephaly	11.3%
213	Lower Extremity Deformities, Congenital	11.3%
214	Upper Extremity Deformities, Congenital	11.3%
215	Single umbilical artery	11.3%
216	Niemann-Pick Disease, Type C	11.3%
217	Retrognathia	11.2%
218	Porphyrias, Hepatic	11.2%
219	Carbamoyl-Phosphate Synthase I Deficiency Disease	11.2%
220	Peutz-Jeghers Syndrome	11.1%
221	Thrombasthenia	11.1%
222	Antithrombin III Deficiency	11.1%
223	Protein C Deficiency	11.1%
224	Afibrinogenemia	11%
225	Factor VII Deficiency	11%
226	Factor X Deficiency	11%
227	Factor XII Deficiency	11%
228	Hemophilia A	11%
229	Activated Protein C Resistance	11%
230	Factor II deficiency	11%
231	Factor VIII Deficiency	11%
232	Factor V deficiency	11%
233	Factor XI Deficiency	11%
234	Hypoprothrombinemias	11%
235	Fanconi Anemia	11%
236	Anemia, Diamond-Blackfan	11%
237	Laryngomalacia	10.9%
238	Pectus carinatum	10.8%
239	Hyperandrogenism	10.8%
240	Bladder Exstrophy	10.7%
241	Epispadias	10.7%
242	Multicystic Dysplastic Kidney	10.7%
243	Anemia, Neonatal	10.6%
244	Persistent Fetal Circulation Syndrome	10.6%
245	Retinopathy of Prematurity	10.6%
246	Umbilical hernia	10.6%
247	Behcet Syndrome	10.5%
248	Alkaptonuria	10.5%
249	Glycogen Storage Disease	10.5%
250	Hypophosphatasia	10.5%
251	Propionic acidemia	10.5%
252	Dihydropyrimidine Dehydrogenase Deficiency	10.5%
253	Cystinosis	10.5%
254	Genetic Diseases, Inborn	10.4%
255	Prognathism	10.4%
256	Multiple Endocrine Neoplasia	10.3%
257	Toxoplasmosis, Congenital	10.3%
258	Congenital Hypothyroidism	10.1%
259	Friedreich Ataxia	10.1%
260	Dermatitis, Atopic	10.1%
261	Aortic coarctation	10.1%
262	Cor Triatriatum	10.1%
263	Coronary Vessel Anomalies	10.1%
264	Dental Enamel Hypoplasia	10.1%
265	Patent ductus arteriosus	10.1%
266	Ebstein Anomaly	10.1%
267	Heart Septal Defects	10.1%
268	Hypodontia	10.1%
269	Macrostomia	10.1%
270	Microstomia	10.1%
271	Tetralogy of Fallot	10.1%
272	Transposition of Great Vessels	10.1%
273	Hypoplastic Left Heart Syndrome	10.1%
274	May-Thurner Syndrome	10.1%
275	Craniofacial Dysostosis	10%
276	Wolff-Parkinson-White Syndrome	10%
277	Deformity	10%
278	Hydrops Fetalis	9.8%
279	Familial Periodic Paralysis	9.8%
280	Color blindness	9.7%
281	Ophthalmia Neonatorum	9.7%
282	Neonatal Abstinence Syndrome	9.6%
283	Fetal Growth Retardation	9.4%
284	Fetal Hypoxia	9.4%
285	Fetal Alcohol Spectrum Disorders	9.4%
286	Ocular Motility Disorders	9.3%
287	Cyclophoria	9.3%
288	Syphilis, Congenital	9.3%
289	Hypolipoproteinemias	9.3%
290	Papillon-Lefevre Disease	9.3%
291	Hyperlipidemia, Familial Combined	9.2%
292	Hyperlipoproteinemia Type III	9.2%
293	Retinoblastoma	9.2%
294	Long QT Syndrome	9.1%
295	Platybasia	9.1%
296	Tricuspid Atresia	9.1%
297	Arrhythmogenic Right Ventricular Dysplasia	9.1%
298	Gonadal Dysgenesis	9%
299	Bronchomalacia	9%
300	Adrenogenital Syndrome	9%
301	Tracheomalacia	9%
302	Ovotesticular Disorders of Sex Development	9%
303	Glycogen Storage Disease Type I	8.7%
304	Glycogen Storage Disease Type V	8.7%
305	Denys-Drash Syndrome	8.7%
306	Aortopulmonary Septal Defect	8.5%
307	Double Outlet Right Ventricle	8.5%
308	Endocardial Cushion Defects	8.5%
309	Myocardial bridging	8.5%
310	Aorticopulmonary Septal Defect	8.5%
311	Congenital Hyperinsulinism	8.5%
312	Chorioamnionitis	8.4%
313	Lactose Intolerance	8.3%
314	Variegate Porphyria	8.3%
315	Acute intermittent porphyria	8.3%
316	Porphyria Cutanea Tarda	8.3%
317	Hyperhomocysteinemia	8.3%
318	Renal Aminoacidurias	8.3%
319	Fanconi Syndrome	8.3%
320	Pseudohypoaldosteronism	8.3%
321	Liddle Syndrome	8.3%
322	Hyperlipoproteinemia Type IV	8.3%
323	Hyperlipoproteinemia Type V	8.3%
324	Hypokalemic periodic paralysis	8%
325	Optic Neuropathy	7.9%
326	Nephroblastoma	7.8%
327	Hypoalphalipoproteinemias	7.7%
328	Truncus Arteriosus, Persistent	7.7%
329	Goldenhar Syndrome	7.7%
330	Leukomalacia, Periventricular	7.7%
331	Gout	7.6%
332	Romano-Ward Syndrome	7.6%
333	Multiple Endocrine Neoplasia Type 1	7.6%
334	Pseudohypoparathyroidism	7.6%
335	Familial Hypophosphatemic Rickets	7.6%
336	Renal tubular acidosis	7.5%
337	Adenomatous Polyposis Coli	7.2%
338	Paralysis, Obstetric	7.2%
339	Bronchopulmonary Dysplasia	7.1%
340	MELAS Syndrome	7.1%
341	Talipes	7%
342	Pupil Disorders	6.9%
343	Cystinuria	6.9%
344	Ophthalmoplegic Migraine	6.8%
345	Congenital clubfoot	6.6%
346	Vertical Talus	6.6%
347	Respiratory Distress Syndrome, Newborn	6.5%
348	Arteriovenous fistula	6.4%
349	Glycosuria, Renal	6.3%
350	Arthritis, Gouty	6.3%
351	Corneal Scar	6.2%
352	Miller Fisher Syndrome	6.2%
353	Vision Disorders	6.1%
354	Metamorphopsia	6.1%
355	Visual Impairment	6.1%
356	Uveal Neoplasms	6.1%
357	Eyelid Neoplasms	6.1%
358	Retinal Hemorrhage	6.1%
359	Asthenopia	6%
360	Conjunctival Diseases	6%
361	Corneal Diseases	6%
362	Eyelid Diseases	6%
363	Lacrimal Apparatus Diseases	6%
364	Lens Diseases	6%
365	Ocular Hypertension	6%
366	Ocular Hypotension	6%
367	Retinal Diseases	6%
368	Scleral Diseases	6%
369	Vitreous Detachment	6%
370	Posterior Vitreous Detachment	6%
371	Xerophthalmia	6%
372	Low Tension Glaucoma	6%
373	Iridocorneal endothelial syndrome	6%
374	Keratoconjunctivitis Sicca	5.9%
375	Opsoclonus-Myoclonus Syndrome	5.9%
376	Progressive supranuclear palsy	5.9%
377	Multiple System Atrophy	5.7%
378	Eye Injuries	5.7%
379	Nesidioblastosis	5.7%
380	Chorioretinitis	5.7%
381	Kernicterus	5.6%
382	Stiff-Person Syndrome	5.5%
383	Neuromyelitis Optica	5.4%
384	Ophthalmoplegia	5.4%
385	External Ophthalmoplegia	5.4%
386	Corneal Ulcer	5.3%
387	Choroid Hemorrhage	5.3%
388	Pars Planitis	5.3%
389	Restless Legs Syndrome	5.3%
390	Eye Infection	5.2%
391	Eye Manifestations	5.2%
392	Eye Neoplasms	5.2%
393	Motor Neuron Disease	5.2%
394	Optic Atrophy	5.1%
395	Optic Neuritis	5.1%
396	Papilledema	5.1%
397	Strabismus	5.1%
398	Tolosa-Hunt Syndrome	5.1%
399	Polyradiculoneuropathy	5.1%
400	Polyradiculoneuritis	5.1%
401	Keratoconjunctivitis	5.1%
402	Amblyopia	5%
403	Horner Syndrome	5%
404	Trachoma	5%
405	Cranial nerve diseases	5%
406	Demyelinating Diseases	5%
407	Demyelination	5%
408	Neuromuscular Diseases	5%
409	Chronobiology Disorders	5%
410	Subacute Combined Degeneration	4.9%
411	Amyotrophic Lateral Sclerosis	4.9%
412	Hyaline Membrane Disease	4.9%
413	Corneal Perforation	4.7%
414	Hordeolum	4.7%
415	Meningoencephalitis	4.7%
416	Eye Hemorrhage	4.6%
417	Optic Neuropathy, Ischemic	4.6%
418	Anterior Ischemic Optic Neuropathy	4.6%
419	Uveomeningoencephalitic Syndrome	4.5%
420	Anisocoria	4.5%
421	Tonic Pupil	4.5%
422	Spinal Muscular Atrophy	4.5%
423	Progressive Muscular Atrophy	4.5%
424	Trauma, Nervous System	4.4%
425	Leukoencephalitis, Acute Hemorrhagic	4.4%
426	Lewy Body Disease	4.4%
427	Choroiditis	4.4%
428	Iridocyclitis	4.4%
429	Iritis	4.4%
430	Guillain-Barre Syndrome	4.4%
431	Nervous System Neoplasms	4.4%
432	Neurologic Manifestations	4.4%
433	Neurotoxicity Syndromes	4.4%
434	Parkinson Disease	4.3%
435	Myelitis, Transverse	4.3%
436	Encephalomyelitis	4.3%
437	Prion Diseases	4.3%
438	Autonomic Dysreflexia	4.3%
439	Complex Regional Pain Syndromes	4.3%
440	Striatonigral Degeneration	4.2%
441	Orbital Myositis	4.1%
442	Diplopia	4.1%
443	Scotoma	4.1%
444	Photophobia	4.1%
445	Amaurosis	4.1%
446	Blindness	4.1%
447	Acanthamoeba Keratitis	4.1%
448	Keratitis, Herpetic	4.1%
449	Cytomegalovirus Retinitis	4.1%
450	Bacterial conjunctivitis	4%
451	Pneumocephalus	4%
452	Poliomyelitis	4%
453	Lambert-Eaton Myasthenic Syndrome	3.9%
454	Sleep Wake Disorders	3.9%
455	Angioid Streaks	3.9%
456	Anisometropia	3.9%
457	Aphakia	3.9%
458	Astigmatism	3.9%
459	Blepharitis	3.9%
460	Blepharoptosis	3.9%
461	Blepharospasm	3.9%
462	Choroid Diseases	3.9%
463	Conjunctivitis	3.9%
464	Corneal edema	3.9%
465	Corneal Opacity	3.9%
466	Dacryocystitis	3.9%
467	Dry Eye Syndromes	3.9%
468	Ectropion	3.9%
469	Enophthalmos	3.9%
470	Entropion	3.9%
471	Episcleritis	3.9%
472	Exophthalmos	3.9%
473	Glaucoma	3.9%
474	Iris Diseases	3.9%
475	Keratitis	3.9%
476	Keratoconus	3.9%
477	Lacrimal Duct Obstruction	3.9%
478	Lens dislocation	3.9%
479	Lens Subluxation	3.9%
480	Mydriasis	3.9%
481	Myopia	3.9%
482	Presbyopia	3.9%
483	Pterygium	3.9%
484	Retinal Detachment	3.9%
485	Retinitis	3.9%
486	Scleritis	3.9%
487	Uveitis	3.9%
488	Corneal Neovascularization	3.9%
489	Orbital Pseudotumor	3.9%
490	Cataract	3.9%
491	Pinguecula	3.9%
492	Trichiasis	3.9%
493	Spinal Cord Injuries	3.9%
494	Marchiafava-Bignami Disease	3.8%
495	Peripheral Nerve Injuries	3.8%
496	Panophthalmitis	3.8%
497	Shy-Drager Syndrome	3.8%
498	Esotropia	3.8%
499	Exotropia	3.8%
500	Myasthenia Gravis	3.8%
501	Asterixis	3.8%
502	Ballismus	3.8%
503	Causalgia	3.7%
504	Epidural Abscess	3.7%
505	Olfactory Nerve Injuries	3.7%
506	Dyskinesia, Drug-Induced	3.7%
507	Leukoencephalopathy, Progressive Multifocal	3.6%
508	MPTP Poisoning	3.6%
509	Optic Nerve Glioma	3.6%
510	Encephalomyelitis, Acute Disseminated	3.5%
511	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.5%
512	Chronic Fatigue Syndrome	3.5%
513	Kearns-Sayre syndrome	3.5%
514	Sleep Disorders, Circadian Rhythm	3.5%
515	Endophthalmitis	3.4%
516	Pemphigoid, Benign Mucous Membrane	3.4%
517	Retinal Artery Occlusion	3.4%
518	Orbital Cellulitis	3.4%
519	Retinal Vasculitis	3.4%
520	Hypertensive Retinopathy	3.4%
521	Retrobulbar Hemorrhage	3.4%
522	Corneal Endothelial Cell Loss	3.4%
523	Hyphema	3.4%
524	Retinal Neovascularization	3.4%
525	Vitreous Hemorrhage	3.4%
526	Lupus Vasculitis, Central Nervous System	3.4%
527	Neuroleptic Malignant Syndrome	3.4%
528	Myelinolysis, Central Pontine	3.4%
529	Botulism	3.4%
530	Myelitis	3.4%
531	Progressive bulbar palsy	3.4%
532	Bulbar palsy	3.4%
533	Facial Nerve Injuries	3.3%
534	Hemianopsia	3.3%
535	Amaurosis Fugax	3.1%
536	Blindness, Cortical	3.1%
537	Akathisia, Drug-Induced	3.1%
538	Myasthenia Gravis, Autoimmune, Experimental	3%
539	Limbic Encephalitis	3%
540	Retinal Vein Occlusion	3%
541	Diabetic Retinopathy	3%
542	Eye pain	3%
543	Brain Injuries	3%
544	Epilepsy, Post-Traumatic	3%
545	Brain Neoplasms	3%
546	Multiple Sclerosis	3%
547	Spinal Cord Neoplasms	3%
548	Reflex Sympathetic Dystrophy	2.9%
549	Subdural Effusion	2.9%
550	Parkinsonian Disorders	2.9%
551	Nocturnal Myoclonus Syndrome	2.9%
552	Brain Diseases	2.9%
553	Dysautonomia	2.9%
554	Meningitis	2.9%
555	Movement Disorders	2.9%
556	Pachymeningitis	2.9%
557	Spinal Cord Diseases	2.9%
558	Vagus Nerve Disorder	2.9%
559	Glossopharyngeal Neuralgia	2.9%
560	Abducens Nerve Diseases	2.9%
561	Heavy Metal Poisoning, Nervous System	2.9%
562	Neuromuscular Junction Diseases	2.9%
563	Tauopathies	2.9%
564	Trochlear Nerve Diseases	2.9%
565	Peripheral Nervous System Diseases	2.9%
566	Angle Closure Glaucoma	2.9%
567	Glaucoma, Open-Angle	2.9%
568	Macular degeneration	2.9%
569	Panuveitis	2.9%
570	Retinal Drusen	2.9%
571	Retinal Necrosis Syndrome, Acute	2.9%
572	Retinoschisis	2.9%
573	Exfoliation Syndrome	2.9%
574	Dementia, Vascular	2.8%
575	Brain Hemorrhage, Traumatic	2.8%
576	Vasculitis, Central Nervous System	2.8%
577	Jet Lag Syndrome	2.8%
578	Brain Abscess	2.7%
579	Cerebellar Neoplasms	2.6%
580	Scrapie	2.6%
581	Central Cord Syndrome	2.6%
582	Central Nervous System Infection	2.6%
583	Myopathy	2.6%
584	Presenile dementia	2.6%
585	Senile dementia	2.6%
586	Meningitis, Bacterial	2.6%
587	Meningitis, Fungal	2.6%
588	Chorea	2.6%
589	Acrodynia	2.6%
590	Facial Nerve Diseases	2.6%
591	Craniocerebral Trauma	2.6%
592	Parasomnia	2.6%
593	Dyssomnias	2.6%
594	Vestibulocochlear Nerve Diseases	2.6%
595	Decerebrate State	2.6%
596	Hemiparesis	2.6%
597	Meningism	2.6%
598	Paresis	2.6%
599	Seizures	2.6%
600	Sensation Disorders	2.6%
601	Central Nervous System Neoplasms	2.6%
602	Complex partial seizures	2.6%
603	Monoparesis	2.6%
604	Neurogenic Inflammation	2.6%
605	Gait Disorders, Neurologic	2.6%
606	Neuromuscular Manifestations	2.6%
607	Sweating, Gustatory	2.5%
608	Auriculotemporal Syndrome	2.5%
609	Choroidal Neovascularization	2.5%
610	Meige Syndrome	2.5%
611	Brachial Plexus Neuritis	2.5%
612	Neuralgic Amyotrophy	2.5%
613	Cerebral Ventriculitis	2.5%
614	Carotid Artery Injuries	2.5%
615	Vocal Cord Paralysis	2.5%
616	Anterior uveitis	2.4%
617	Uveitis, Posterior	2.4%
618	Tuberculosis, Meningeal	2.4%
619	Paraneoplastic Cerebellar Degeneration	2.3%
620	Cerebrospinal Fluid Otorrhea	2.3%
621	Cerebrospinal Fluid Rhinorrhea	2.3%
622	Neuritis, Autoimmune, Experimental	2.3%
623	Gait Ataxia	2.3%
624	Brain Death	2.3%
625	Coma, Post-Head Injury	2.3%
626	Neurobehavioral Manifestations	2.3%
627	Tarsal Tunnel Syndrome	2.3%
628	Cauda Equina Syndrome	2.3%
629	Posterior Leukoencephalopathy Syndrome	2.3%
630	Posterior reversible encephalopathy syndrome	2.3%
631	Paraneoplastic Encephalomyelitis	2.3%
632	Alice in Wonderland Syndrome	2.3%
633	Sturge-Weber Syndrome	2.3%
634	Vertigo	2.3%
635	Alcohol-Induced Disorders, Nervous System	2.3%
636	Pituitary Adenoma	2.3%
637	Pituitary Neoplasms	2.3%
638	Herpes Zoster Ophthalmicus	2.3%
639	Creutzfeldt-Jakob disease	2.2%
640	Basal Ganglia Cerebrovascular Disease	2.2%
641	Brain Injuries, Diffuse	2.2%
642	Traumatic Brain Injury	2.2%
643	Alcohol Withdrawal Seizures	2.2%
644	Cerebellar Ataxia	2.2%
645	Supratentorial Neoplasms	2.2%
646	Torticollis	2.2%
647	Multiple Sclerosis, Chronic Progressive	2.2%
648	Multiple Sclerosis, Relapsing-Remitting	2.2%
649	Brain Concussion	2.2%
650	Toxoplasmosis, Cerebral	2.2%
651	Akathisia	2.1%
652	Restlessness	2.1%
653	Psychomotor Agitation	2.1%
654	Myoclonic Epilepsy	2.1%
655	Epilepsy, Temporal Lobe	2.1%
656	Epilepsy, Rolandic	2.1%
657	Benign Rolandic Epilepsy	2.1%
658	Voice Disorders	2.1%
659	Voice Disturbance	2.1%
660	Carpal Tunnel Syndrome	2%
661	Vascular Headaches	2%
662	Graves Disease	2%
663	neurofibroma	2%
664	Hypoxia-Ischemia, Brain	2%
665	Sciatica	2%
666	Tardive Dyskinesia	2%
667	Persistent Vegetative State	2%
668	Basal Ganglia Hemorrhage	2%
669	Vertebral Artery Dissection	2%
670	Amnesia, Transient Global	2%
671	Gait Apraxia	2%
672	Akinetic Mutism	1.9%
673	Anoxic Encephalopathy	1.9%
674	Arachnoiditis	1.9%
675	Basal Ganglia Diseases	1.9%
676	Brain Damage, Chronic	1.9%
677	Cerebellar Diseases	1.9%
678	Encephalitis	1.9%
679	Encephalomalacia	1.9%
680	Epilepsy	1.9%
681	Hydrocephalus	1.9%
682	Congenital Hydrocephalus	1.9%
683	Hypothalamic Diseases	1.9%
684	Aseptic Meningitis	1.9%
685	Neuritis	1.9%
686	Polyneuritis	1.9%
687	Radiculitis	1.9%
688	Syringomyelia	1.9%
689	Thalamic Diseases	1.9%
690	Intracranial Hypertension	1.9%
691	Polyneuropathy	1.9%
692	Mononeuritis	1.9%
693	Aura	1.9%
694	Leukoencephalopathy	1.9%
695	Essential Tremor	1.9%
696	Neuroaxonal Dystrophies	1.9%
697	Familial Tremor	1.9%
698	Headache Disorders	1.9%
699	Mononeuropathies	1.9%
700	Intracranial Hypotension	1.9%
701	Brachial Plexus Neuropathies	1.9%
702	Radiculopathy	1.9%
703	Mononeuropathy Multiplex	1.9%
704	Nerve Root Compression	1.9%
705	Brain Edema	1.9%
706	Brain Hypoxia	1.9%
707	Aqueductal Stenosis	1.9%
708	Pneumorrhachis	1.9%
709	Writer's Cramp	1.9%
710	Subarachnoid Hemorrhage, Traumatic	1.9%
711	Carotid Artery, Internal, Dissection	1.9%
712	Juvenile Myoclonic Epilepsy	1.9%
713	Myoclonic Epilepsies, Progressive	1.9%
714	Subacute Sclerosing Panencephalitis	1.9%
715	Cubital Tunnel Syndrome	1.8%
716	Diffuse Axonal Injury	1.8%
717	Brain Stem Neoplasms	1.8%
718	Meningitis, Cryptococcal	1.8%
719	Reflex, Abnormal	1.8%
720	Hyporeflexia	1.8%
721	Hyperreflexia	1.8%
722	Meningitis, Listeria	1.8%
723	Meningitis, Haemophilus	1.8%
724	Meningitis, Pneumococcal	1.8%
725	Frontotemporal dementia	1.8%
726	Mitochondrial Encephalomyopathies	1.8%
727	Putaminal Hemorrhage	1.8%
728	Infarction, Middle Cerebral Artery	1.8%
729	Infarction, Anterior Cerebral Artery	1.8%
730	Infarction, Posterior Cerebral Artery	1.8%
731	Acoustic Neuroma	1.8%
732	Brain Diseases, Metabolic	1.7%
733	Cerebrovascular Disorders	1.7%
734	Myositis	1.7%
735	Cerebrovascular Insufficiency	1.7%
736	Isaacs syndrome	1.7%
737	Arsenic Poisoning	1.7%
738	Dementia	1.7%
739	Myotonic Disorders	1.7%
740	Central Nervous System Fungal Infections	1.7%
741	Conus Medullaris Syndrome	1.7%
742	Spinal Cord Vascular Diseases	1.7%
743	Diabetic Neuropathies	1.7%
744	Facial Injuries	1.7%
745	Facial Neuralgia	1.7%
746	Diabetic Amyotrophy	1.7%
747	Diabetic Autonomic Neuropathy	1.7%
748	Sleep Talking	1.7%
749	Manganese Poisoning	1.7%
750	Sleep Disorders, Intrinsic	1.7%
751	Orthostatic intolerance	1.7%
752	Anosmia	1.7%
753	Ataxia	1.7%
754	Athetosis	1.7%
755	Catalepsy	1.7%
756	Dystonia	1.7%
757	Hemiplegia	1.7%
758	Locked-In Syndrome	1.7%
759	Meningeal Neoplasms	1.7%
760	Muscle Hypertonia	1.7%
761	Muscle hypotonia	1.7%
762	Myoclonus	1.7%
763	Myotonia	1.7%
764	Neuralgia	1.7%
765	Paraplegia	1.7%
766	Pseudobulbar Palsy	1.7%
767	Quadriplegia	1.7%
768	Spasm	1.7%
769	Spastic Paraplegia	1.7%
770	Status Epilepticus	1.7%
771	Taste Disorders	1.7%
772	Tremor	1.7%
773	Monoplegia	1.7%
774	Hypokinesia	1.7%
775	Paraparesis	1.7%
776	Bradykinesia	1.7%
777	Waxy flexibility	1.7%
778	Action Tremor	1.7%
779	Resting Tremor	1.7%
780	Dysosmia	1.7%
781	Quadriparesis	1.7%
782	Mercury Poisoning, Nervous System	1.7%
783	Olfaction Disorders	1.7%
784	Myokymia	1.7%
785	Lead Poisoning, Nervous System	1.7%
786	Vestibular Neuronitis	1.7%
787	Somatosensory Disorders	1.7%
788	Neuropathic pain	1.7%
789	Hyperkinesia	1.7%
790	Intention tremor	1.7%
791	Pituitary Apoplexy	1.7%
792	Sicca Syndrome	1.7%
793	Sjogren's Syndrome	1.7%
794	Auditory Perceptual Disorders	1.7%
795	Brain Contusion	1.7%
796	Giant Cell Arteritis	1.7%
797	Temporal Arteritis	1.7%
798	Brain Infarction	1.7%
799	Choroid Plexus Papilloma	1.7%
800	West Nile Fever	1.6%
801	Hand-Arm Vibration Syndrome	1.5%
802	Fibromyalgia	1.5%
803	Central Nervous System Bacterial Infections	1.5%
804	Medial Tibial Stress Syndrome	1.5%
805	Facial Hemiatrophy	1.5%
806	Melkersson-Rosenthal Syndrome	1.5%
807	Mitochondrial Myopathies	1.5%
808	Confusion	1.5%
809	Facial paralysis	1.5%
810	Lethargy	1.5%
811	Memory Disorders	1.5%
812	Muscle Cramp	1.5%
813	Perceptual Disorders	1.5%
814	Psychomotor Disorders	1.5%
815	Eosinophilia-Myalgia Syndrome	1.5%
816	Anhedonia	1.5%
817	Disorientation	1.5%
818	Facial Paresis	1.5%
819	Memory Loss	1.5%
820	Hemisensory Neglect	1.5%
821	Dysacusis	1.5%
822	Alexia	1.5%
823	Dyslexia	1.5%
824	Sleep Bruxism	1.5%
825	Muscular Atrophy	1.5%
826	Respiratory Paralysis	1.5%
827	Tetany	1.5%
828	Cerebral Infarction	1.5%
829	Brain Stem Infarctions	1.5%
830	Cerebral Palsy	1.4%
831	Epilepsies, Partial	1.4%
832	Epilepsy, Generalized	1.4%
833	Pseudotumor Cerebri	1.4%
834	Sciatic Neuropathy	1.4%
835	Hypertensive Encephalopathy	1.4%
836	Ulnar Neuropathies	1.4%
837	Lesion of Sciatic Nerve	1.4%
838	Simple Partial Seizures	1.4%
839	Epilepsy, Reflex	1.4%
840	Ulnar Neuritis	1.4%
841	Radial nerve compression	1.4%
842	Radial Tunnel Syndrome	1.4%
843	Peroneal Neuropathies	1.4%
844	Radial Neuropathy	1.4%
845	Median Neuropathy	1.4%
846	Sciatic Nerve Palsy	1.4%
847	Femoral Neuropathy	1.4%
848	Tibial Neuropathy	1.4%
849	Ulnar Nerve Palsy	1.4%
850	Postural Orthostatic Tachycardia Syndrome	1.4%
851	Radial nerve palsy	1.4%
852	Headache Disorders, Primary	1.4%
853	Headache Disorders, Secondary	1.4%
854	Medication overuse headache	1.4%
855	Hematoma, Subdural	1.4%
856	Hematoma, Epidural, Cranial	1.4%
857	Moyamoya Disease	1.4%
858	Neurofibrosarcoma	1.4%
859	Lateral Medullary Syndrome	1.4%
860	Consciousness Disorders	1.4%
861	Mental Retardation	1.4%
862	Muscle Weakness	1.4%
863	Depressed Level of Consciousness	1.4%
864	Mental deficiency	1.4%
865	Intellectual Disability	1.4%
866	Bell Palsy	1.4%
867	Catatonia	1.4%
868	Herpes Zoster Oticus	1.3%
869	Aphonia	1.3%
870	Sleep Deprivation	1.3%
871	Dysphonia	1.3%
872	Pituitary Diseases	1.3%
873	Thoracic Outlet Syndrome	1.3%
874	Hematoma, Subdural, Intracranial	1.3%
875	Hematoma, Subdural, Chronic	1.3%
876	Hematoma, Subdural, Acute	1.3%
877	Carotid Artery Diseases	1.3%
878	Brain Ischemia	1.3%
879	Hypotension, Orthostatic	1.3%
880	Sleep Apnea Syndromes	1.3%
881	Cerebrovascular accident	1.3%
882	Polymyositis	1.3%
883	Kluver-Bucy Syndrome	1.3%
884	Vasospasm, Intracranial	1.3%
885	Spinal Cord Ischemia	1.3%
886	Intracranial Arterial Diseases	1.3%
887	Post-Exercise Hypotension	1.3%
888	Disorders of Excessive Somnolence	1.3%
889	Sleep Initiation and Maintenance Disorders	1.3%
890	Night Terrors	1.3%
891	Somnambulism	1.3%
892	Trigeminal Nerve Disorder	1.3%
893	Transient Insomnia	1.3%
894	Sleep Paralysis	1.3%
895	Chronic Insomnia	1.3%
896	REM Sleep Behavior Disorder	1.3%
897	Hypersomnia	1.3%
898	Dysgeusia	1.3%
899	Formication	1.3%
900	Hyperalgesia	1.3%
901	Hyperesthesia	1.3%
902	Hypesthesia	1.3%
903	Language Disorders	1.3%
904	Numbness	1.3%
905	Paresthesia	1.3%
906	Paraparesis, Spastic	1.3%
907	Trismus	1.3%
908	Epilepsia Partialis Continua	1.3%
909	Hypogeusia	1.3%
910	Meningeal Carcinomatosis	1.3%
911	Brown-Sequard Syndrome	1.3%
912	Lockjaw	1.3%
913	Allodynia	1.3%
914	Lead Poisoning, Nervous System, Childhood	1.3%
915	Lead Poisoning, Nervous System, Adult	1.3%
916	Ageusia	1.3%
917	Tuberculosis, Central Nervous System	1.3%
918	Myalgia	1.2%
919	Polyradiculopathy	1.2%
920	Post-Traumatic Headache	1.2%
921	Tension Headache	1.2%
922	Epilepsy, Complex Partial	1.2%
923	Migraine Disorders	1.2%
924	Abdominal Migraine	1.2%
925	Status Migrainosus	1.2%
926	Cervicogenic Headache	1.2%
927	Hoarseness	1.1%
928	Muscle Rigidity	1.1%
929	Muscle Spasticity	1.1%
930	Cogwheel Rigidity	1.1%
931	Hemifacial Spasm	1.1%
932	Nuchal Rigidity	1.1%
933	Reye Syndrome	1.1%
934	Neuroaspergillosis	1.1%
935	Pyomyositis	1.1%
936	Intracranial Embolism and Thrombosis	1.1%
937	Hepatic Encephalopathy	1.1%
938	Agnosia	1.1%
939	Apraxias	1.1%
940	Hallucinations	1.1%
941	Hyperacusis	1.1%
942	Tinnitus	1.1%
943	Visual Agnosia	1.1%
944	Anosognosia	1.1%
945	Wernicke-Korsakoff Syndrome	1.1%
946	Phonophobia	1.1%
947	Hearing Loss	1.1%
948	Alcohol Withdrawal Delirium	1.1%
949	Sarcopenia	1.1%
950	Cluster Headache	1.1%
951	Migraine with Aura	1.1%
952	Familial Hemiplegic Migraine	1.1%
953	Chronic Paroxysmal Hemicrania	1.1%
954	SUNCT Syndrome	1.1%
955	Paroxysmal Hemicrania	1.1%
956	Empty Sella Syndrome	1.1%
957	Hyperpituitarism	1.1%
958	Hypopituitarism	1.1%
959	Hypophysitis	1.1%
960	Cerebral Arterial Diseases	1%
961	Vertebrobasilar Insufficiency	1%
962	Anterior Spinal Artery Syndrome	1%
963	Basilar Artery Stenosis	1%
964	Vertebral Artery Stenosis	1%
965	Sleep Apnea, Obstructive	1%
966	Sleep Apnea, Central	1%
967	Intracranial Hemorrhage, Hypertensive	1%
968	Transient Cerebral Ischemia	1%
969	Narcolepsy	1%
970	Trigeminal Neuralgia	1%
971	Kleine-Levin Syndrome	1%
972	Agraphia	1%
973	Anomia	1%
974	Cluttering	1%
975	Language Development Disorders	1%
976	Speech Disorders	1%
977	Syncope	1%
978	Stupor	1%
979	Dysgraphia	1%
980	Presyncope	1%
981	Dyslalia	1%
982	Waterhouse-Friderichsen Syndrome	1%
983	Pseudorabies	1%
984	Amnesia	1%
985	Delirium	1%
986	Dissociative Amnesia	1%
987	Global Amnesia	1%
988	Meningioma	1%
989	Neurosyphilis	1%
990	Hyperprolactinemia	0.9%
991	Subclavian Steal Syndrome	0.9%
992	Pick Disease of the Brain	0.9%
993	Cataplexy	0.9%
994	Aphasia	0.9%
995	Articulation Disorders	0.9%
996	Echolalia	0.9%
997	Stuttering	0.9%
998	Dysphasia	0.9%
999	Eye Burns	0.9%
1000	Malaria, Cerebral	0.9%
1001	Carotid Stenosis	0.9%
1002	Intracranial Aneurysm	0.9%
1003	Neurocysticercosis	0.9%
1004	Dyscalculia	0.9%
1005	Intracranial Arteriosclerosis	0.9%
1006	Cerebral Atherosclerosis	0.9%
1007	Subarachnoid Hemorrhage	0.9%
1008	Cerebral Arteriosclerosis	0.9%
1009	Cerebral Hemorrhage	0.9%
1010	Cerebral Thrombosis	0.9%
1011	Intracranial Embolism	0.9%
1012	Intracranial Thrombosis	0.9%
1013	Deafness	0.9%
1014	Hearing Loss, Sudden	0.9%
1015	Gerstmann Syndrome	0.9%
1016	Hearing Loss, Bilateral	0.9%
1017	Hearing Loss, High-Frequency	0.9%
1018	Hearing Loss, Mixed Conductive-Sensorineural	0.9%
1019	Prosopagnosia	0.9%
1020	Apraxia, Ideomotor	0.9%
1021	Charles Bonnet Syndrome	0.9%
1022	Hearing Loss, Unilateral	0.9%
1023	Complete Hearing Loss	0.9%
1024	Alien Hand Syndrome	0.9%
1025	Deaf Mutism	0.9%
1026	Wernicke Encephalopathy	0.9%
1027	AIDS Dementia Complex	0.9%
1028	Phantom pain	0.9%
1029	Phantom Limb Pain	0.9%
1030	Lyme Neuroborreliosis	0.9%
1031	Dysarthria	0.9%
1032	Dermatomyositis	0.8%
1033	Mutism	0.8%
1034	Selective Mutism	0.8%
1035	Acromegaly	0.8%
1036	Retrograde amnesia	0.8%
1037	Amnesia, Anterograde	0.8%
1038	Cerebral Amyloid Angiopathy	0.8%
1039	Carotid Artery Thrombosis	0.8%
1040	Sinus Thrombosis, Intracranial	0.8%
1041	Alexia, Pure	0.8%
1042	Cavernous Sinus Thrombosis	0.8%
1043	Sagittal Sinus Thrombosis	0.8%
1044	Nelson Syndrome	0.7%
1045	Prolactinoma	0.7%
1046	Growth Hormone-Secreting Pituitary Adenoma	0.7%

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