MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Thoracic Outlet Syndrome

(UMLS:C0039984)

Definition:: A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the superior thoracic outlet. This may result from a variety of anomalies such as a CERVICAL RIB, anomalous fascial bands, and abnormalities of the origin or insertion of the anterior or medial scalene muscles. Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (Adams et al., Principles of Neurology, 6th ed, pp214-5).
UMLS ID:: C0039984
MeSH ID:: D013901

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.668.829.550.850

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.863

Synonym(s)

Thoracic Outlet Syndrome

CERVICOTHORACIC OUTLET SYNDROME

THORACIC OUTLET SYNDROME

TOS

TOS - Thoracic outlet syndrome

Thoracic outlet syndrome

cervicothoracic outlet; syndrome

outlet syndrome thoracic

outlet syndromes thoracic

10.

outlet; thoracic, syndrome

11.

syndrome; cervicothoracic outlet

12.

syndrome; thoracic outlet

13.

thoracic outlet syndrome

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 11	OFFSIDES US FAERS
2	Deferasirox	FAERS: 5	US FAERS
3	Desogestrel	FAERS: 5	US FAERS
4	4-hydroxybutyric acid	FAERS: 4	US FAERS
5	Norgestrel	FAERS: 4	US FAERS
6	Carbamazepine	FAERS: 3	US FAERS
7	Isotretinoin	FAERS: 3	US FAERS
8	NuvaRing	FAERS: 3	OFFSIDES US FAERS
9	Fingolimod Hydrochloride	FAERS: 2	US FAERS
10	Ondansetron	FAERS: 2	US FAERS
11	Duloxetine Hydrochloride	FAERS: 1	US FAERS
12	Hydroxyurea	FAERS: 1	US FAERS
13	Methylphenidate	FAERS: 1	US FAERS
14	Pregabalin	FAERS: 1	US FAERS
15	Sertraline	FAERS: 1	US FAERS
16	Teriparatide	FAERS: 1	US FAERS
17	Venlafaxine Hydrochloride	FAERS: 1	US FAERS
18	norgestimate, ethinyl estradiol drug combination	FAERS: 1	US FAERS
19	rofecoxib	FAERS: 1	OFFSIDES US FAERS
20	teriflunomide	FAERS: 1	US FAERS
21	trovafloxacin	FAERS: 1	US FAERS
22	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride		OFFSIDES
23	Amoxicillin		OFFSIDES
24	Benzoyl Peroxide		OFFSIDES
25	Bupropion		OFFSIDES
26	Cetirizine		OFFSIDES
27	Diane		OFFSIDES
28	Doxycycline		OFFSIDES
29	Fondaparinux		OFFSIDES
30	Methylprednisolone		OFFSIDES
31	Mycophenolic Acid		OFFSIDES
32	Nitrofurantoin		OFFSIDES
33	Phenazopyridine		OFFSIDES
34	Pramipexole		OFFSIDES
35	Raloxifene Hydrochloride		OFFSIDES
36	Spironolactone		OFFSIDES
37	Sulfamethoxazole		OFFSIDES
38	Tadalafil		OFFSIDES
39	Valacyclovir		OFFSIDES
40	fexofenadine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Tarsal Tunnel Syndrome	33.3%
2	Cauda Equina Syndrome	33.3%
3	Hand-Arm Vibration Syndrome	31.9%
4	Aortic Aneurysm	30.3%
5	Aortitis	30.3%
6	Leriche Syndrome	30.3%
7	Periphlebitis	30.3%
8	Phlebitis	30.3%
9	Thromboangiitis Obliterans	30.3%
10	Thrombophlebitis	28.5%
11	Myocardial Ischemia	27.8%
12	Aneurysm	27.6%
13	Angiomatosis	27.6%
14	Aortic Diseases	27.6%
15	Arterial Occlusive Diseases	27.6%
16	Hyperemia	27.6%
17	Hypotension	27.6%
18	Superior Vena Cava Syndrome	27.6%
19	Telangiectasis	27.6%
20	Vasculitis	27.6%
21	Venous Insufficiency	27.6%
22	Peripheral Vascular Diseases	27.6%
23	Embolism and Thrombosis	27.6%
24	Angiodysplasia	27.6%
25	Capillary Leak Syndrome	27.6%
26	Prehypertension	27.6%
27	Postphlebitic Syndrome	27.5%
28	Carpal Tunnel Syndrome	26.7%
29	Retinal Vein Occlusion	25.6%
30	Blue Toe Syndrome	25.5%
31	Coronary Aneurysm	25.2%
32	Aortic Rupture	25%
33	Aortic Aneurysm, Abdominal	24.8%
34	Aortic Aneurysm, Thoracic	24.8%
35	Carotid Artery Thrombosis	24.5%
36	Malignant Atrophic Papulosis	24.2%
37	Shwartzman Phenomenon	24%
38	Neuritis	23.6%
39	Polyneuritis	23.6%
40	Radiculitis	23.6%
41	Polyneuropathy	23.6%
42	Mononeuritis	23.6%
43	Mononeuropathies	23.6%
44	Brachial Plexus Neuropathies	23.6%
45	Radiculopathy	23.6%
46	Mononeuropathy Multiplex	23.6%
47	Nerve Root Compression	23.6%
48	Intracranial Embolism and Thrombosis	23.2%
49	Brachial Plexus Neuritis	23.1%
50	Neuralgic Amyotrophy	23.1%
51	Cerebrovascular Disorders	23.1%
52	Cerebrovascular Insufficiency	23.1%
53	Spinal Cord Vascular Diseases	23.1%
54	Coronary Thrombosis	23%
55	Coronary Artery Disease	23%
56	Moyamoya Disease	22.9%
57	Myocardial Reperfusion Injury	22.9%
58	Carotid Stenosis	22.8%
59	Intracranial Aneurysm	22.8%
60	Complex Regional Pain Syndromes	22.2%
61	Vascular System Injuries	21.6%
62	Cubital Tunnel Syndrome	21.6%
63	Compartment syndromes	20.9%
64	Hepatic Veno-Occlusive Disease	20.9%
65	Peliosis Hepatis	20.9%
66	Varicocele	20.9%
67	Vasculitis, Central Nervous System	20.7%
68	Intracranial Arteriosclerosis	20.7%
69	Cerebral Atherosclerosis	20.7%
70	Cerebral Arteriosclerosis	20.7%
71	Causalgia	20.5%
72	Diabetic Angiopathies	20.5%
73	Reperfusion Injury	20.5%
74	Splenic Infarction	20.5%
75	Vascular Neoplasms	20.5%
76	Vasoplegia	20.5%
77	Hemorrhoids	20.3%
78	Aneurysm, Dissecting	20.2%
79	Arteriosclerosis	20.2%
80	Arteritis	20.2%
81	Embolism	20.2%
82	Erythromelalgia	20.2%
83	Fibromuscular Dysplasia	20.2%
84	Malignant Hypertension	20.2%
85	Raynaud Disease	20.2%
86	Thromboembolism	20.2%
87	Thrombosis	20.2%
88	Essential Hypertension	20.2%
89	Aneurysm, Ruptured	20.2%
90	Iliac Aneurysm	20.2%
91	Pulmonary artery stenosis	20.2%
92	White Coat Hypertension	20.2%
93	Systemic Vasculitis	20.2%
94	Embolus	20.2%
95	Coronary heart disease	20.2%
96	Myocardial Infarction	20.2%
97	Acute Coronary Syndrome	20.2%
98	Polyarteritis Nodosa	19.9%
99	Takayasu Arteritis	19.9%
100	Cerebral Thrombosis	19.6%
101	Intracranial Embolism	19.6%
102	Intracranial Thrombosis	19.6%
103	Arteriovenous fistula	18.9%
104	Optic Neuropathy, Ischemic	18.6%
105	Anterior Ischemic Optic Neuropathy	18.6%
106	Giant Cell Arteritis	18%
107	Temporal Arteritis	18%
108	Isaacs syndrome	17.9%
109	Brain Infarction	17.9%
110	Peripheral Nerve Injuries	17.9%
111	Sinus Thrombosis, Intracranial	17.9%
112	Guillain-Barre Syndrome	17.7%
113	Diabetic Neuropathies	17.6%
114	Diabetic Amyotrophy	17.6%
115	Diabetic Autonomic Neuropathy	17.6%
116	Neuralgia	17.5%
117	Neuropathic pain	17.5%
118	Motor Neuron Disease	17.4%
119	Neuromuscular Junction Diseases	17.2%
120	Infarction, Middle Cerebral Artery	17%
121	Infarction, Anterior Cerebral Artery	17%
122	Infarction, Posterior Cerebral Artery	17%
123	Cavernous Sinus Thrombosis	17%
124	Sagittal Sinus Thrombosis	17%
125	Subarachnoid Hemorrhage, Traumatic	16.7%
126	Carotid Artery, Internal, Dissection	16.7%
127	Arteriosclerosis Obliterans	16.7%
128	Atherosclerosis	16.7%
129	Carotid Artery Diseases	16.7%
130	Brain Ischemia	16.7%
131	Air Embolism	16.7%
132	Endarteritis	16.7%
133	Hypotension, Orthostatic	16.7%
134	Cerebrovascular accident	16.7%
135	Venous Thrombosis	16.7%
136	Deep Vein Thrombosis	16.7%
137	Vasospasm, Intracranial	16.7%
138	Spinal Cord Ischemia	16.7%
139	Intracranial Arterial Diseases	16.7%
140	Venous Thromboembolism	16.7%
141	Post-Exercise Hypotension	16.7%
142	Mesenteric vascular insufficiency	16.6%
143	Coronary Occlusion	16.5%
144	Microvascular Angina	16.5%
145	Coronary Stenosis	16.5%
146	ST segment elevation myocardial infarction	16.5%
147	Lemierre Syndrome	16.5%
148	Kounis Syndrome	16.3%
149	Vertebral Artery Dissection	16.2%
150	Angioedema	16.1%
151	Colitis, Ischemic	16.1%
152	Sciatica	16%
153	May-Thurner Syndrome	16%
154	Angina Pectoris	15.9%
155	Cerebral Infarction	15.9%
156	Brain Stem Infarctions	15.9%
157	Sciatic Neuropathy	15.6%
158	Ulnar Neuropathies	15.6%
159	Lesion of Sciatic Nerve	15.6%
160	Ulnar Neuritis	15.6%
161	Radial nerve compression	15.6%
162	Radial Tunnel Syndrome	15.6%
163	Peroneal Neuropathies	15.6%
164	Radial Neuropathy	15.6%
165	Median Neuropathy	15.6%
166	Sciatic Nerve Palsy	15.6%
167	Femoral Neuropathy	15.6%
168	Tibial Neuropathy	15.6%
169	Ulnar Nerve Palsy	15.6%
170	Radial nerve palsy	15.6%
171	Embolism, Amniotic Fluid	15.5%
172	Sturge-Weber Syndrome	15.5%
173	Retinal Artery Occlusion	15.4%
174	Retinal Vasculitis	15.4%
175	Hypertensive Retinopathy	15.4%
176	Acrodynia	15.2%
177	Anterior Compartment Syndrome	15.1%
178	Vasculitis, Leukocytoclastic, Cutaneous	15.1%
179	Gastric Antral Vascular Ectasia	15.1%
180	Abdominal Compartment Syndrome	15.1%
181	Varicose Ulcer	15%
182	Primary Graft Dysfunction	15%
183	Lateral Medullary Syndrome	14.9%
184	Carotid Artery Injuries	14.8%
185	Coronary Restenosis	14.8%
186	Basal Ganglia Cerebrovascular Disease	14.6%
187	Heart Diseases	14.5%
188	Vascular Headaches	14.2%
189	Reflex Sympathetic Dystrophy	14.2%
190	Polyradiculoneuropathy	13.6%
191	Polyradiculoneuritis	13.6%
192	Cerebral Arterial Diseases	13.6%
193	Vertebrobasilar Insufficiency	13.6%
194	Anterior Spinal Artery Syndrome	13.6%
195	Basilar Artery Stenosis	13.6%
196	Vertebral Artery Stenosis	13.6%
197	Intracranial Hemorrhage, Hypertensive	13.6%
198	Transient Cerebral Ischemia	13.6%
199	Myopathy	13.5%
200	CREST Syndrome	13.5%
201	Shock, Cardiogenic	13.2%
202	Basal Ganglia Hemorrhage	13.2%
203	Stiff-Person Syndrome	13.1%
204	Angina, Unstable	13.1%
205	Scimitar Syndrome	12.8%
206	Intermittent Claudication	12.7%
207	Pulmonary Embolism	12.7%
208	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	12.7%
209	No-Reflow Phenomenon	12.5%
210	Shy-Drager Syndrome	12.5%
211	Dementia, Vascular	12.4%
212	Mesenteric Vascular Occlusion	12.2%
213	Mucocutaneous Lymph Node Syndrome	12.2%
214	Diabetic Retinopathy	12.2%
215	Leukomalacia, Periventricular	12.2%
216	Hypoxia-Ischemia, Brain	12.1%
217	Livedo Reticularis	12.1%
218	Subclavian Steal Syndrome	12.1%
219	Renal hypertension	12%
220	Renal Artery Obstruction	12%
221	Renal Artery Stenosis	12%
222	Putaminal Hemorrhage	12%
223	Hemangioma, Cavernous	11.9%
224	Scurvy	11.9%
225	Angina Pectoris, Variant	11.7%
226	Polyradiculopathy	11.6%
227	Hepatic Vein Thrombosis	11.4%
228	Budd-Chiari Syndrome	11.4%
229	Pulmonary Infarction	11.2%
230	Cranial nerve diseases	10.8%
231	Demyelinating Diseases	10.8%
232	Demyelination	10.8%
233	Chronobiology Disorders	10.8%
234	Subarachnoid Hemorrhage	10.8%
235	Cerebral Hemorrhage	10.8%
236	Pregnancy Complications, Cardiovascular	10.8%
237	Cardiovascular Abnormalities	10.8%
238	Chronic Fatigue Syndrome	10.7%
239	Poliomyelitis	10.6%
240	Miller Fisher Syndrome	10.4%
241	Lupus Vasculitis, Central Nervous System	10.4%
242	Aortic Valve Stenosis	10.1%
243	Cardiomyopathy, Dilated	10.1%
244	Progressive bulbar palsy	10.1%
245	Pulmonary Valve Stenosis	10.1%
246	Bulbar palsy	10.1%
247	Spinal Muscular Atrophy	10.1%
248	Progressive Muscular Atrophy	10.1%
249	Ischemic contracture	10.1%
250	Angioedemas, Hereditary	10%
251	Tricuspid Atresia	10%
252	Arrhythmogenic Right Ventricular Dysplasia	10%
253	Cryoglobulinemia	9.9%
254	Pituitary Apoplexy	9.9%
255	Diabetic Foot	9.9%
256	Hypertension, Renovascular	9.8%
257	Hereditary Angioedema Type III	9.8%
258	Hereditary Angioedema Types I and II	9.8%
259	Cerebral Amyloid Angiopathy	9.6%
260	Ataxia Telangiectasia	9.6%
261	Myasthenia Gravis	9.5%
262	Neuritis, Autoimmune, Experimental	9.3%
263	Cardiac Tamponade	9.2%
264	Endocarditis	9.2%
265	Cardiac Arrest	9.2%
266	Heart failure	9.2%
267	Pericardial effusion	9.2%
268	Pericarditis	9.2%
269	Pneumopericardium	9.2%
270	Cor pulmonale	9.2%
271	Ventricular Outflow Obstruction	9.2%
272	Ventricular Dysfunction	9.2%
273	Cardiomyopathies	9.2%
274	Pleuropericarditis	9.2%
275	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9.1%
276	Granulomatosis with polyangiitis	9%
277	Hypertrophic Cardiomyopathy	8.7%
278	Hypertrophic obstructive cardiomyopathy	8.7%
279	Amyotrophic Lateral Sclerosis	8.6%
280	Purpura, Hyperglobulinemic	8.5%
281	Trauma, Nervous System	8.4%
282	Supravalvular aortic stenosis	8.3%
283	Lown-Ganong-Levine Syndrome	8.3%
284	neurofibroma	8.2%
285	Nervous System Neoplasms	8.1%
286	Neurologic Manifestations	8.1%
287	Neurotoxicity Syndromes	8.1%
288	Heart Block	8.1%
289	Tachycardia	8.1%
290	Tachyarrhythmia	8.1%
291	Aortic coarctation	8%
292	Cor Triatriatum	8%
293	Coronary Vessel Anomalies	8%
294	Patent ductus arteriosus	8%
295	Ebstein Anomaly	8%
296	Bacterial Endocarditis	8%
297	Heart Septal Defects	8%
298	Tetralogy of Fallot	8%
299	Transposition of Great Vessels	8%
300	Hypoplastic Left Heart Syndrome	8%
301	Botulism	7.9%
302	POEMS Syndrome	7.7%
303	Myositis	7.7%
304	Myotonic Disorders	7.7%
305	Myasthenic Syndromes, Congenital	7.7%
306	Behcet Syndrome	7.5%
307	Brain Hemorrhage, Traumatic	7.5%
308	Waldenstrom Macroglobulinemia	7.5%
309	Multiple Myeloma	7.5%
310	Multiple System Atrophy	7.3%
311	Charcot-Marie-Tooth Disease	7.3%
312	Ocular Motility Disorders	7.2%
313	Cyclophoria	7.2%
314	Lambert-Eaton Myasthenic Syndrome	7.1%
315	Rheumatoid Vasculitis	7.1%
316	Sick Sinus Syndrome	7%
317	Cardiac Output, High	7%
318	Myocardial Stunning	7%
319	Low Cardiac Output Syndrome	7%
320	Encephalomyelitis	6.8%
321	Cardiomegaly	6.8%
322	Postpericardiotomy Syndrome	6.8%
323	Prion Diseases	6.8%
324	Autonomic Dysreflexia	6.8%
325	Cardiac Hypertrophy	6.8%
326	Restless Legs Syndrome	6.8%
327	Hematoma, Subdural	6.8%
328	Hematoma, Epidural, Cranial	6.8%
329	Rheumatic Heart Disease	6.8%
330	Aortic Valve Insufficiency	6.7%
331	Restrictive cardiomyopathy	6.7%
332	Endocardial Fibroelastosis	6.7%
333	Heart Rupture, Post-Infarction	6.7%
334	Mitral Valve Insufficiency	6.7%
335	Mitral Valve Stenosis	6.7%
336	Myocarditis	6.7%
337	Pericarditis, Constrictive	6.7%
338	Pulmonary Valve Insufficiency	6.7%
339	Tricuspid Valve Insufficiency	6.7%
340	Tricuspid Valve Stenosis	6.7%
341	Ventricular Dysfunction, Left	6.7%
342	Right Ventricular Dysfunction	6.7%
343	Endomyocardial Fibrosis	6.7%
344	Carditis	6.7%
345	Heart Failure, Systolic	6.7%
346	Heart Failure, Diastolic	6.7%
347	Pseudoxanthoma Elasticum	6.7%
348	Dextrocardia	6.7%
349	Long QT Syndrome	6.7%
350	MELAS Syndrome	6.6%
351	Adams-Stokes Syndrome	6.6%
352	Atrioventricular Block	6.6%
353	Bundle-Branch Block	6.6%
354	Atrial Premature Complexes	6.6%
355	Sinoatrial Block	6.6%
356	Tachycardia, Paroxysmal	6.6%
357	Supraventricular tachycardia	6.6%
358	Tachycardia, Ventricular	6.6%
359	Wolff-Parkinson-White Syndrome	6.6%
360	Tachycardia, Reciprocating	6.6%
361	Sleep Wake Disorders	6.6%
362	Aortopulmonary Septal Defect	6.6%
363	Double Outlet Right Ventricle	6.6%
364	Endocardial Cushion Defects	6.6%
365	Myocardial bridging	6.6%
366	Aorticopulmonary Septal Defect	6.6%
367	Subacute Combined Degeneration	6.3%
368	Fibromyalgia	6.2%
369	Medial Tibial Stress Syndrome	6.2%
370	Hematoma, Subdural, Intracranial	6.2%
371	Hematoma, Subdural, Chronic	6.2%
372	Hematoma, Subdural, Acute	6.2%
373	Amyloid Neuropathies, Familial	6.2%
374	Dural Arteriovenous Fistula	6.2%
375	Mitochondrial Myopathies	6.1%
376	Eosinophilia-Myalgia Syndrome	6.1%
377	Marchiafava-Bignami Disease	5.9%
378	Tachycardia, Atrioventricular Nodal Reentry	5.9%
379	Tachycardia, Ectopic Atrial	5.9%
380	Tachycardia, Ectopic Junctional	5.9%
381	Sinus Tachycardia	5.9%
382	Torsades de Pointes	5.9%
383	Accelerated Idioventricular Rhythm	5.9%
384	Truncus Arteriosus, Persistent	5.9%
385	Brain Diseases	5.7%
386	Dysautonomia	5.7%
387	Meningitis	5.7%
388	Movement Disorders	5.7%
389	Pachymeningitis	5.7%
390	Spinal Cord Diseases	5.7%
391	Vagus Nerve Disorder	5.7%
392	Glossopharyngeal Neuralgia	5.7%
393	Abducens Nerve Diseases	5.7%
394	Heavy Metal Poisoning, Nervous System	5.7%
395	Tauopathies	5.7%
396	Trochlear Nerve Diseases	5.7%
397	Parkinson Disease	5.7%
398	Spinal Cord Injuries	5.7%
399	Ophthalmoplegic Migraine	5.6%
400	Aortic Valve Prolapse	5.6%
401	Tricuspid Valve Prolapse	5.6%
402	Takotsubo Cardiomyopathy	5.6%
403	Meningoencephalitis	5.5%
404	Romano-Ward Syndrome	5.4%
405	Asterixis	5.4%
406	Ballismus	5.4%
407	Subacute Bacterial Endocarditis	5.2%
408	Sinus Arrhythmia	5%
409	Atrial Fibrillation	5%
410	Atrial Flutter	5%
411	Edema, Cardiac	5%
412	Myelitis	5%
413	Ventricular Fibrillation	5%
414	Ventricular Flutter	5%
415	Parasystole	5%
416	Paroxysmal atrial fibrillation	5%
417	Bradycardia	5%
418	Diabetic Cardiomyopathies	5%
419	Dandy-Walker Syndrome	5%
420	Familial Periodic Paralysis	5%
421	Noonan Syndrome	5%
422	Cardiomyopathy, Alcoholic	5%
423	Ectopia Cordis	5%
424	Myotonia Congenita	5%
425	Pneumocephalus	5%
426	Sudden Cardiac Death	5%
427	Polymyositis	5%
428	Left Ventricular Hypertrophy	5%
429	Right Ventricular Hypertrophy	5%
430	Single umbilical artery	5%
431	Lewy Body Disease	5%
432	Chagas Cardiomyopathy	5%
433	Myotonic Dystrophy	5%
434	Myasthenia Gravis, Autoimmune, Experimental	4.9%
435	Neuroleptic Malignant Syndrome	4.7%
436	Myelinolysis, Central Pontine	4.7%
437	Neurofibrosarcoma	4.7%
438	Sleep Disorders, Circadian Rhythm	4.7%
439	Striatonigral Degeneration	4.7%
440	Alstrom Syndrome	4.6%
441	Marfan Syndrome	4.5%
442	Central Nervous System Infection	4.5%
443	Optic Neuropathy	4.5%
444	Central Nervous System Cysts	4.5%
445	Epidural Abscess	4.4%
446	Olfactory Nerve Injuries	4.4%
447	Progressive supranuclear palsy	4.4%
448	Carcinoid Heart Disease	4.4%
449	Facial Nerve Diseases	4.3%
450	Craniocerebral Trauma	4.3%
451	Parasomnia	4.3%
452	Dyssomnias	4.3%
453	MPTP Poisoning	4.3%
454	Myelitis, Transverse	4.3%
455	Myalgia	4.3%
456	Vestibulocochlear Nerve Diseases	4.3%
457	Decerebrate State	4.3%
458	Hemiparesis	4.3%
459	Hydranencephaly	4.3%
460	Meningism	4.3%
461	Neural Tube Defects	4.3%
462	Paresis	4.3%
463	Seizures	4.3%
464	Sensation Disorders	4.3%
465	Tethered Cord Syndrome	4.3%
466	Central Nervous System Neoplasms	4.3%
467	Complex partial seizures	4.3%
468	Iniencephaly	4.3%
469	Craniorachischisis	4.3%
470	Exencephaly	4.3%
471	Monoparesis	4.3%
472	Septo-Optic Dysplasia	4.3%
473	Cortical Dysplasia	4.3%
474	Neurogenic Inflammation	4.3%
475	Gait Disorders, Neurologic	4.3%
476	Neuromuscular Manifestations	4.3%
477	Malformations of Cortical Development	4.3%
478	Refsum Disease	4.3%
479	Sweating, Gustatory	4.2%
480	Auriculotemporal Syndrome	4.2%
481	Dyskinesia, Drug-Induced	4.2%
482	Subdural Effusion	4.2%
483	Parkinsonian Disorders	4.2%
484	Nocturnal Myoclonus Syndrome	4.2%
485	Leukoencephalitis, Acute Hemorrhagic	4.2%
486	Encephalomyelitis, Acute Disseminated	4.1%
487	Sinus Arrest, Cardiac	4.1%
488	Opsoclonus-Myoclonus Syndrome	4.1%
489	Muscular Dystrophy	4.1%
490	Orbital Myositis	4.1%
491	Fabry Disease	4%
492	Brain Injuries	4%
493	Brain Neoplasms	4%
494	Dyspnea, Paroxysmal	4%
495	Multiple Sclerosis	4%
496	Spinal Cord Neoplasms	4%
497	Pyomyositis	4%
498	Neuromyelitis Optica	3.9%
499	Horner Syndrome	3.9%
500	Akathisia, Drug-Induced	3.9%
501	Dystonia Musculorum Deformans	3.9%
502	Facial Nerve Injuries	3.8%
503	Mitochondrial Encephalomyopathies	3.8%
504	Kearns-Sayre syndrome	3.6%
505	Williams Syndrome	3.6%
506	Pupil Disorders	3.5%
507	Neurobehavioral Manifestations	3.5%
508	Paraneoplastic Encephalomyelitis	3.4%
509	Leukoencephalopathy, Progressive Multifocal	3.4%
510	Uveomeningoencephalitic Syndrome	3.4%
511	Scrapie	3.4%
512	Vertigo	3.4%
513	Central Cord Syndrome	3.4%
514	Alcohol-Induced Disorders, Nervous System	3.4%
515	Akinetic Mutism	3.4%
516	Anoxic Encephalopathy	3.4%
517	Arachnoiditis	3.4%
518	Basal Ganglia Diseases	3.4%
519	Brain Abscess	3.4%
520	Brain Damage, Chronic	3.4%
521	Cerebellar Diseases	3.4%
522	Encephalitis	3.4%
523	Encephalomalacia	3.4%
524	Epilepsy	3.4%
525	Hydrocephalus	3.4%
526	Congenital Hydrocephalus	3.4%
527	Hypothalamic Diseases	3.4%
528	Aseptic Meningitis	3.4%
529	Ophthalmoplegia	3.4%
530	Syringomyelia	3.4%
531	Thalamic Diseases	3.4%
532	Intracranial Hypertension	3.4%
533	External Ophthalmoplegia	3.4%
534	Aura	3.4%
535	Leukoencephalopathy	3.4%
536	Essential Tremor	3.4%
537	Neuroaxonal Dystrophies	3.4%
538	Familial Tremor	3.4%
539	Headache Disorders	3.4%
540	Intracranial Hypotension	3.4%
541	Brain Edema	3.4%
542	Brain Hypoxia	3.4%
543	Aqueductal Stenosis	3.4%
544	Pneumorrhachis	3.4%
545	Writer's Cramp	3.4%
546	Jet Lag Syndrome	3.3%
547	Presenile dementia	3.3%
548	Senile dementia	3.3%
549	Meningitis, Bacterial	3.3%
550	Meningitis, Fungal	3.3%
551	Chorea	3.3%
552	Meige Syndrome	3.3%
553	Cerebral Ventriculitis	3.3%
554	Limbic Encephalitis	3.3%
555	Epilepsy, Post-Traumatic	3.3%
556	Hypokalemic periodic paralysis	3.3%
557	Huntington Disease	3.1%
558	Tuberous Sclerosis	3.1%
559	Welander Distal Myopathy	3%
560	Vocal Cord Paralysis	2.9%
561	Voice Disorders	2.9%
562	Voice Disturbance	2.9%
563	Posterior Leukoencephalopathy Syndrome	2.9%
564	Posterior reversible encephalopathy syndrome	2.9%
565	Lafora Disease	2.9%
566	Unverricht-Lundborg Syndrome	2.9%
567	Canavan Disease	2.9%
568	Alexander Disease	2.9%
569	Smith-Magenis syndrome	2.8%
570	Brain Death	2.8%
571	Coma, Post-Head Injury	2.8%
572	Amblyopia	2.8%
573	Paraneoplastic Cerebellar Degeneration	2.8%
574	Cerebrospinal Fluid Otorrhea	2.7%
575	Cerebrospinal Fluid Rhinorrhea	2.7%
576	Gait Ataxia	2.7%
577	Cerebellar Neoplasms	2.7%
578	Creutzfeldt-Jakob disease	2.6%
579	Brain Injuries, Diffuse	2.6%
580	Traumatic Brain Injury	2.6%
581	Cerebellar Ataxia	2.6%
582	Supratentorial Neoplasms	2.6%
583	Torticollis	2.6%
584	Multiple Sclerosis, Chronic Progressive	2.6%
585	Multiple Sclerosis, Relapsing-Remitting	2.6%
586	Turner Syndrome	2.6%
587	Friedreich Ataxia	2.6%
588	Brain Diseases, Metabolic	2.6%
589	Optic Atrophy	2.6%
590	Optic Neuritis	2.6%
591	Papilledema	2.6%
592	Strabismus	2.6%
593	Tolosa-Hunt Syndrome	2.6%
594	Arsenic Poisoning	2.6%
595	Dementia	2.6%
596	Central Nervous System Fungal Infections	2.6%
597	Conus Medullaris Syndrome	2.6%
598	Dermatomyositis	2.5%
599	Facial Injuries	2.5%
600	Facial Neuralgia	2.5%
601	Sleep Talking	2.5%
602	Manganese Poisoning	2.5%
603	Sleep Disorders, Intrinsic	2.5%
604	Orthostatic intolerance	2.5%
605	Anosmia	2.5%
606	Ataxia	2.5%
607	Athetosis	2.5%
608	Catalepsy	2.5%
609	Dystonia	2.5%
610	Hemiplegia	2.5%
611	Locked-In Syndrome	2.5%
612	Meningeal Neoplasms	2.5%
613	Meningomyelocele	2.5%
614	Muscle Hypertonia	2.5%
615	Muscle hypotonia	2.5%
616	Myoclonus	2.5%
617	Myotonia	2.5%
618	Paraplegia	2.5%
619	Pseudobulbar Palsy	2.5%
620	Quadriplegia	2.5%
621	Spasm	2.5%
622	Spastic Paraplegia	2.5%
623	Status Epilepticus	2.5%
624	Taste Disorders	2.5%
625	Tremor	2.5%
626	Spina Bifida	2.5%
627	Monoplegia	2.5%
628	Hypokinesia	2.5%
629	Paraparesis	2.5%
630	Bradykinesia	2.5%
631	Waxy flexibility	2.5%
632	Action Tremor	2.5%
633	Resting Tremor	2.5%
634	Dysosmia	2.5%
635	Quadriparesis	2.5%
636	Mercury Poisoning, Nervous System	2.5%
637	Olfaction Disorders	2.5%
638	Myokymia	2.5%
639	Lead Poisoning, Nervous System	2.5%
640	Vestibular Neuronitis	2.5%
641	Somatosensory Disorders	2.5%
642	Hyperkinesia	2.5%
643	Intention tremor	2.5%
644	Muscular Dystrophy, Duchenne	2.5%
645	Alcohol Withdrawal Seizures	2.5%
646	Myoclonic Epilepsy	2.5%
647	Epilepsy, Temporal Lobe	2.5%
648	Epilepsy, Rolandic	2.5%
649	Benign Rolandic Epilepsy	2.5%
650	Hepatolenticular Degeneration	2.4%
651	Kartagener Syndrome	2.4%
652	Reflex, Abnormal	2.4%
653	Hyporeflexia	2.4%
654	Hyperreflexia	2.4%
655	Akathisia	2.4%
656	Restlessness	2.4%
657	Psychomotor Agitation	2.4%
658	Tuberculosis, Meningeal	2.3%
659	Tardive Dyskinesia	2.3%
660	Persistent Vegetative State	2.3%
661	Cerebral Palsy	2.2%
662	Epilepsies, Partial	2.2%
663	Epilepsy, Generalized	2.2%
664	Pseudotumor Cerebri	2.2%
665	Hypertensive Encephalopathy	2.2%
666	Simple Partial Seizures	2.2%
667	Epilepsy, Reflex	2.2%
668	Postural Orthostatic Tachycardia Syndrome	2.2%
669	Headache Disorders, Primary	2.2%
670	Headache Disorders, Secondary	2.2%
671	Medication overuse headache	2.2%
672	Alice in Wonderland Syndrome	2.1%
673	Amnesia, Transient Global	2.1%
674	Gait Apraxia	2.1%
675	Vision Disorders	2.1%
676	Metamorphopsia	2.1%
677	Visual Impairment	2.1%
678	Central Nervous System Bacterial Infections	2.1%
679	Facial Hemiatrophy	2%
680	Melkersson-Rosenthal Syndrome	2%
681	Juvenile Myoclonic Epilepsy	2%
682	Myoclonic Epilepsies, Progressive	2%
683	Brain Concussion	2%
684	Anisocoria	2%
685	Confusion	2%
686	Facial paralysis	2%
687	Lethargy	2%
688	Memory Disorders	2%
689	Muscle Cramp	2%
690	Perceptual Disorders	2%
691	Psychomotor Disorders	2%
692	Tonic Pupil	2%
693	Anhedonia	2%
694	Disorientation	2%
695	Facial Paresis	2%
696	Memory Loss	2%
697	Hemisensory Neglect	2%
698	Dysacusis	2%
699	Optic Nerve Glioma	2%
700	Sleep Bruxism	2%
701	Anencephaly	2%
702	Meningocele	2%
703	Muscular Atrophy	2%
704	Respiratory Paralysis	2%
705	Toxoplasmosis, Cerebral	2%
706	Encephalocele	2%
707	Tetany	2%
708	Diffuse Axonal Injury	2%
709	Brain Stem Neoplasms	2%
710	Meningitis, Cryptococcal	1.9%
711	Meningitis, Listeria	1.9%
712	Meningitis, Haemophilus	1.9%
713	Meningitis, Pneumococcal	1.9%
714	Frontotemporal dementia	1.9%
715	Pituitary Adenoma	1.8%
716	Pituitary Neoplasms	1.8%
717	Acoustic Neuroma	1.8%
718	Pituitary Diseases	1.8%
719	Duane Retraction Syndrome	1.7%
720	Consciousness Disorders	1.7%
721	Mental Retardation	1.7%
722	Muscle Weakness	1.7%
723	Depressed Level of Consciousness	1.7%
724	Mental deficiency	1.7%
725	Intellectual Disability	1.7%
726	Mobius Syndrome	1.7%
727	Bell Palsy	1.7%
728	Catatonia	1.7%
729	Herpes Zoster Oticus	1.7%
730	Aphonia	1.7%
731	Esotropia	1.7%
732	Exotropia	1.7%
733	Sleep Apnea Syndromes	1.7%
734	Sleep Deprivation	1.7%
735	Kluver-Bucy Syndrome	1.7%
736	Dysphonia	1.7%
737	Post-Traumatic Headache	1.7%
738	Tension Headache	1.7%
739	Epilepsy, Complex Partial	1.7%
740	Migraine Disorders	1.7%
741	Abdominal Migraine	1.7%
742	Status Migrainosus	1.7%
743	Cervicogenic Headache	1.7%
744	Disorders of Excessive Somnolence	1.7%
745	Sleep Initiation and Maintenance Disorders	1.7%
746	Night Terrors	1.7%
747	Somnambulism	1.7%
748	Trigeminal Nerve Disorder	1.7%
749	Transient Insomnia	1.7%
750	Sleep Paralysis	1.7%
751	Chronic Insomnia	1.7%
752	REM Sleep Behavior Disorder	1.7%
753	Hypersomnia	1.7%
754	Dermal Sinus	1.6%
755	Dysgeusia	1.6%
756	Formication	1.6%
757	Hyperalgesia	1.6%
758	Hyperesthesia	1.6%
759	Hypesthesia	1.6%
760	Language Disorders	1.6%
761	Numbness	1.6%
762	Paresthesia	1.6%
763	Paraparesis, Spastic	1.6%
764	Spina Bifida Cystica	1.6%
765	Trismus	1.6%
766	Spina Bifida Occulta	1.6%
767	Epilepsia Partialis Continua	1.6%
768	Hypogeusia	1.6%
769	Meningeal Carcinomatosis	1.6%
770	Brown-Sequard Syndrome	1.6%
771	Lissencephaly	1.6%
772	Polymicrogyria	1.6%
773	Pachygyria	1.6%
774	Schizencephaly	1.6%
775	Lockjaw	1.6%
776	Allodynia	1.6%
777	Lead Poisoning, Nervous System, Childhood	1.6%
778	Lead Poisoning, Nervous System, Adult	1.6%
779	Periventricular Nodular Heterotopia	1.6%
780	Ageusia	1.6%
781	Auditory Perceptual Disorders	1.6%
782	Tuberculosis, Central Nervous System	1.6%
783	Brain Contusion	1.6%
784	Classical Lissencephalies and Subcortical Band Heterotopias	1.6%
785	Choroid Plexus Papilloma	1.6%
786	Adrenoleukodystrophy	1.6%
787	Subacute Sclerosing Panencephalitis	1.6%
788	Neuronal Ceroid-Lipofuscinoses	1.4%
789	Alexia	1.4%
790	Dyslexia	1.4%
791	Eye Injuries	1.4%
792	Cluster Headache	1.4%
793	Migraine with Aura	1.4%
794	Familial Hemiplegic Migraine	1.4%
795	Chronic Paroxysmal Hemicrania	1.4%
796	SUNCT Syndrome	1.4%
797	Paroxysmal Hemicrania	1.4%
798	Congenital nystagmus	1.4%
799	Diplopia	1.3%
800	Muscle Rigidity	1.3%
801	Muscle Spasticity	1.3%
802	Scotoma	1.3%
803	Photophobia	1.3%
804	Cogwheel Rigidity	1.3%
805	Hemifacial Spasm	1.3%
806	Amaurosis	1.3%
807	Blindness	1.3%
808	Nuchal Rigidity	1.3%
809	Reye Syndrome	1.3%
810	Neuroaspergillosis	1.3%
811	Hepatic Encephalopathy	1.3%
812	Agnosia	1.3%
813	Apraxias	1.3%
814	Hallucinations	1.3%
815	Hemianopsia	1.3%
816	Hyperacusis	1.3%
817	Tinnitus	1.3%
818	Visual Agnosia	1.3%
819	Anosognosia	1.3%
820	Wernicke-Korsakoff Syndrome	1.3%
821	Phonophobia	1.3%
822	Hearing Loss	1.3%
823	Sarcopenia	1.3%
824	Optic Atrophy, Hereditary, Leber	1.3%
825	Aicardi's syndrome	1.3%
826	Empty Sella Syndrome	1.3%
827	Hyperpituitarism	1.3%
828	Hypopituitarism	1.3%
829	Hypophysitis	1.3%
830	Hoarseness	1.3%
831	Cockayne Syndrome	1.3%
832	Alcohol Withdrawal Delirium	1.2%
833	Sleep Apnea, Obstructive	1.2%
834	Sleep Apnea, Central	1.2%
835	Narcolepsy	1.2%
836	Trigeminal Neuralgia	1.2%
837	Kleine-Levin Syndrome	1.2%
838	Agraphia	1.2%
839	Anomia	1.2%
840	Cluttering	1.2%
841	Language Development Disorders	1.2%
842	Speech Disorders	1.2%
843	Syncope	1.2%
844	Stupor	1.2%
845	Dysgraphia	1.2%
846	Presyncope	1.2%
847	Dyslalia	1.2%
848	West Nile Fever	1.2%
849	Pseudorabies	1.2%
850	Amnesia	1.1%
851	Delirium	1.1%
852	Dissociative Amnesia	1.1%
853	Color blindness	1.1%
854	Global Amnesia	1.1%
855	Cri-du-Chat Syndrome	1.1%
856	Down Syndrome	1.1%
857	Brain Diseases, Metabolic, Inborn	1.1%
858	Trisomy 21	1.1%
859	Holoprosencephaly	1.1%
860	Meningioma	1.1%
861	Microcephaly	1.1%
862	Macrocephaly	1.1%
863	Neurosyphilis	1.1%
864	Porencephaly	1.1%
865	Hyperprolactinemia	1%
866	Pick Disease of the Brain	1%
867	Cataplexy	1%
868	Aphasia	1%
869	Articulation Disorders	1%
870	Echolalia	1%
871	Stuttering	1%
872	Dysphasia	1%
873	Toxoplasmosis, Congenital	1%
874	Eye Burns	1%
875	Malaria, Cerebral	1%
876	Neurocysticercosis	1%
877	Amaurosis Fugax	1%
878	Blindness, Cortical	1%
879	Dyscalculia	1%
880	Rett Syndrome	1%
881	Deafness	1%
882	Hearing Loss, Sudden	1%
883	Gerstmann Syndrome	1%
884	Hearing Loss, Bilateral	1%
885	Hearing Loss, High-Frequency	1%
886	Hearing Loss, Mixed Conductive-Sensorineural	1%
887	Prosopagnosia	1%
888	Apraxia, Ideomotor	1%
889	Charles Bonnet Syndrome	1%
890	Hearing Loss, Unilateral	1%
891	Complete Hearing Loss	1%
892	Alien Hand Syndrome	1%
893	Deaf Mutism	1%
894	Prader-Willi Syndrome	0.9%
895	Wernicke Encephalopathy	0.9%
896	AIDS Dementia Complex	0.9%
897	Phantom pain	0.9%
898	Phantom Limb Pain	0.9%
899	Lyme Neuroborreliosis	0.9%
900	Dysarthria	0.9%
901	Corneal Scar	0.8%
902	Kernicterus	0.8%
903	Mutism	0.8%
904	Selective Mutism	0.8%
905	Acromegaly	0.8%
906	Retrograde amnesia	0.8%
907	Amnesia, Anterograde	0.8%
908	Menkes Kinky Hair Syndrome	0.8%
909	Waterhouse-Friderichsen Syndrome	0.8%
910	Alexia, Pure	0.7%
911	Rubinstein-Taybi Syndrome	0.7%
912	Fragile X Syndrome	0.7%
913	Corneal Perforation	0.7%
914	Galactosemias	0.6%
915	Urea Cycle Disorders, Inborn	0.6%
916	Tyrosinemias	0.6%
917	Nelson Syndrome	0.6%
918	Prolactinoma	0.6%
919	Growth Hormone-Secreting Pituitary Adenoma	0.6%
920	Homocystinuria	0.5%
921	Leigh Disease	0.5%
922	Mucopolysaccharidosis II	0.5%
923	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.4%
924	Zellweger Syndrome	0.4%
925	Glycogen storage disease type II	0.4%
926	Gaucher Disease	0.3%
927	Tay-Sachs Disease	0.3%
928	Niemann-Pick Disease, Type C	0.3%

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