MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Respiratory Distress Syndrome, Newborn

(UMLS:C0035220)

Definition:: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
UMLS ID:: C0035220
MeSH ID:: D012127

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.842|C08.618.842

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.614.521.563

Synonym(s)

Respiratory Distress Syndrome, Newborn

Cardiorespiratory distress syndrome of newborn

Congenital alveolar dysplasia

IRDS - Idiopathic respiratory distress syndrome

IRDS of newborn

Idiopathic respiratory distress syndrome

Idiopathic respiratory distress syndrome of newborn

Idiopathic respiratory distress syndrome, NOS

Neonatal Respiratory Distress

10.

Neonatal Respiratory Distress Syndrome

11.

Neonatal respiratory distress syndrome

12.

Newborn Respiratory Distress Syndrome

13.

Newborns (RDS), Respiratory Distress Syndrome Of

14.

Pulmonary hypoperfusion syndrome of newborn

15.

RDS

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Betamethasone	15924982	CTD
2	Cocaine	15280134	CTD
3	Creatinine	19078973	CTD
4	Dexamethasone	View details 9565440 10516395 15044641 15215491	CTD
5	Dobutamine	9175527	CTD
6	Midazolam	8033934	CTD
7	Phenoxybenzamine	15166586	CTD
8	Vitamin A	16877224	CTD
9	carbidopa, levodopa drug combination	9175527	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Respiratory Distress Syndrome, Adult	45.1%
2	Meconium Aspiration Syndrome	34.8%
3	Pneumonia	33.8%
4	Lobar Pneumonia	33.8%
5	Pneumonitis	33.8%
6	Bronchopulmonary Dysplasia	32.7%
7	Bronchitis	32.6%
8	Bronchitis, Chronic	30.8%
9	Idiopathic Pulmonary Fibrosis	29.9%
10	Bronchopneumonia	29.9%
11	Persistent Fetal Circulation Syndrome	29.2%
12	Pleuropneumonia	29.1%
13	Cystic Fibrosis	28.3%
14	Lung Diseases, Fungal	28.2%
15	Pneumoconiosis	28.2%
16	Vocal Cord Dysfunction	28.2%
17	Altitude Sickness	28.1%
18	Atelectasis	28.1%
19	Pulmonary Hypertension	28.1%
20	Pulmonary Alveolar Proteinosis	28.1%
21	Pulmonary Edema	28.1%
22	Pulmonary Fibrosis	28.1%
23	Respiratory Insufficiency	28.1%
24	Hamman-Rich syndrome	28.1%
25	Lung Diseases, Interstitial	28.1%
26	Respiratory Depression	28.1%
27	Lung Diseases, Obstructive	28.1%
28	Respiratory Failure	28.1%
29	Lung Abscess	27.7%
30	Lung Neoplasms	27.7%
31	Tuberculosis, Pulmonary	27.6%
32	Asthma	27.6%
33	Acute Chest Syndrome	26.2%
34	Tracheobronchomegaly	26%
35	Bronchiolitis	24.9%
36	Aspiration Pneumonia	24.7%
37	Granuloma, Laryngeal	24.2%
38	Radiation Pneumonitis	23.4%
39	Radiation Fibrosis	23.4%
40	Asbestosis	22.7%
41	Berylliosis	22.7%
42	Silicosis	22.7%
43	Pleurisy	22.5%
44	Tracheitis	22.5%
45	Lung Injury	22.5%
46	Hepatopulmonary Syndrome	22.5%
47	Respiratory Aspiration	22.5%
48	Apnea	22.2%
49	Cheyne-Stokes Respiration	22.2%
50	Dyspnea	22.2%
51	Hyperventilation	22.2%
52	Mouth Breathing	22.2%
53	Tachypnea	22.2%
54	Pulmonary Embolism	22.1%
55	Pulmonary Eosinophilia	22%
56	Eosinophilic Pneumonia	22%
57	Bronchial Diseases	21.8%
58	Pleural Diseases	21.8%
59	Thoracic Diseases	21.8%
60	Tracheal Diseases	21.8%
61	Pneumonia, Viral	21.2%
62	Scimitar Syndrome	21.1%
63	Airway Obstruction	20.7%
64	Pneumonia, Bacterial	20.7%
65	Choking	20.7%
66	Chronic Obstructive Airway Disease	20.7%
67	Middle Lobe Syndrome	20.7%
68	Acute Lung Injury	20.7%
69	Laryngospasm	20.5%
70	Multiple Pulmonary Nodules	20.3%
71	Pneumonia, Lipid	20.3%
72	Aspergillosis, Allergic Bronchopulmonary	20.3%
73	Retinopathy of Prematurity	19.4%
74	Bronchiolitis Obliterans	18.9%
75	Laryngitis	18.8%
76	Rhinitis	18.8%
77	Bronchial Fistula	18.5%
78	Pleural Neoplasms	18.5%
79	Hemoptysis	18.4%
80	Choanal Atresia	18%
81	Laryngocele	18%
82	Laryngeal Diseases	17.9%
83	Nose Diseases	17.9%
84	Respiratory Tract Infections	17.4%
85	Pleural Effusion, Malignant	17.3%
86	Granuloma, Respiratory Tract	17.1%
87	Respiratory Hypersensitivity	17.1%
88	Respiratory Tract Fistula	17.1%
89	Pulmonary Emphysema	17.1%
90	Hoarseness	16.6%
91	Histiocytosis, Langerhans-Cell	16.4%
92	Pulmonary Aspergillosis	16.4%
93	Bronchopulmonary Aspergillosis	16.4%
94	Hypoventilation	16.4%
95	Acidosis, Respiratory	16.3%
96	Alkalosis, Respiratory	16.3%
97	Sarcoidosis, Pulmonary	16.3%
98	Sleep Apnea Syndromes	16.3%
99	Pulmonary Infarction	16.3%
100	Sinusitis	16.1%
101	Bronchial Neoplasms	16%
102	Primary Ciliary Dyskinesia	15.9%
103	Abdominal Cramps	15.8%
104	Amniotic Band Syndrome	15.8%
105	Asphyxia Neonatorum	15.8%
106	Infantile Colic	15.8%
107	Tracheal Neoplasms	15.8%
108	Farmer's Lung	15.5%
109	Kartagener Syndrome	14.6%
110	Bronchospasm	14%
111	Bronchiectasis	14%
112	Chylothorax	14%
113	Hydropneumothorax	14%
114	Hydrothorax	14%
115	Pneumothorax	14%
116	Tracheal Stenosis	14%
117	Bronchial Hyperreactivity	14%
118	Laryngeal neoplasm	14%
119	Dyspnea, Paroxysmal	13.6%
120	Respiratory Paralysis	13.6%
121	Asthma, Exercise-Induced	13.5%
122	Status Asthmaticus	13.5%
123	Granulomatosis with polyangiitis	13.5%
124	Sleep Apnea, Obstructive	13.5%
125	Sleep Apnea, Central	13.5%
126	Leukomalacia, Periventricular	13.5%
127	Blastomycosis	13.4%
128	Anemia, Neonatal	12.5%
129	Umbilical hernia	12.4%
130	Paranasal Sinus Neoplasms	12.1%
131	Asthma, Occupational	11.9%
132	Laryngostenosis	11.6%
133	Anti-Glomerular Basement Membrane Disease	11.6%
134	Transfusion-Related Acute Lung Injury	11.4%
135	Granuloma, Lethal Midline	11.3%
136	Laryngeal Edema	11.3%
137	Nose Deformities, Acquired	11.3%
138	Invasive Pulmonary Aspergillosis	11.2%
139	Common Cold	11.1%
140	Hemothorax	11.1%
141	Influenza	11.1%
142	Catarrh	11.1%
143	Nose Neoplasms	11%
144	Severe Acute Respiratory Syndrome	11%
145	Laryngopharyngeal Reflux	11%
146	Lung diseases	10.9%
147	Respiration Disorders	10.9%
148	Rhinoscleroma	10.9%
149	Xeroderma	10.8%
150	Mobius Syndrome	10.8%
151	Neonatal Abstinence Syndrome	10.6%
152	Hay fever	10.5%
153	Rhinitis, Allergic, Perennial	10.5%
154	Epiglottitis	10.3%
155	Mediastinitis	10.3%
156	Congenital nystagmus	10.3%
157	Toxoplasmosis, Congenital	10.2%
158	Syphilis, Congenital	10.2%
159	Asthma, Aspirin-Induced	10.2%
160	Maxillary Sinus Neoplasms	9.9%
161	Pharyngitis	9.4%
162	Nasal Polyps	9.3%
163	Respiratory Distress Syndrome, Newborn	9.3%
164	Pertussis	9.1%
165	Deformity	9.1%
166	Genetic Diseases, Inborn	9.1%
167	Congenital Hyperinsulinism	8.8%
168	Laryngomalacia	8.7%
169	Eosinophilic Granuloma	8.4%
170	Mediastinal Cyst	8.3%
171	Paralysis, Obstetric	8.3%
172	Pericardial Cyst	8.3%
173	Thymic Cyst	8.3%
174	Croup	8.2%
175	Mediastinal Emphysema	8.2%
176	Rhinitis, Vasomotor	8.2%
177	Voice Disorders	8%
178	Voice Disturbance	8%
179	Epistaxis	7.9%
180	Fetal Diseases	7.2%
181	Bronchomalacia	7.2%
182	Tracheomalacia	7.2%
183	Ichthyosis, X-Linked	7.2%
184	Vocal Cord Paralysis	6.9%
185	Beckwith-Wiedemann Syndrome	6.8%
186	Tonsillitis	6.8%
187	Wolf-Hirschhorn Syndrome	6.8%
188	Hyaline Membrane Disease	6.8%
189	Ophthalmia Neonatorum	6.7%
190	Aicardi's syndrome	6.5%
191	Holoprosencephaly	6%
192	Sjogren-Larsson Syndrome	5.9%
193	Smith-Magenis syndrome	5.9%
194	Aphonia	5.8%
195	Cri-du-Chat Syndrome	5.8%
196	Down Syndrome	5.8%
197	Retropharyngeal Abscess	5.8%
198	Dysphonia	5.8%
199	Trisomy 21	5.8%
200	CHARGE Syndrome	5.7%
201	Nesidioblastosis	5.7%
202	Hyperkeratosis, Epidermolytic	5.3%
203	Abnormalities, Drug-Induced	5.3%
204	Situs Inversus	5.3%
205	Ectodermal Dysplasia	5.1%
206	Nasopharyngitis	5.1%
207	Aplasia Cutis Congenita	5.1%
208	Prader-Willi Syndrome	5%
209	Rubinstein-Taybi Syndrome	5%
210	Fragile X Syndrome	5%
211	Nail-Patella Syndrome	5%
212	Peritonsillar Abscess	4.8%
213	Kernicterus	4.5%
214	Cockayne Syndrome	4.5%
215	Marfan Syndrome	4.4%
216	Alstrom Syndrome	4.4%
217	Eye Abnormalities	4.3%
218	Neoplastic Syndromes, Hereditary	4.3%
219	Cardiovascular Abnormalities	4.3%
220	Skin Abnormalities	4.2%
221	Lymphatic Abnormalities	4.2%
222	Congenital Microtia	4.2%
223	Multiple Epiphyseal Dysplasia	4.2%
224	Osteochondrodysplasias	4.2%
225	Pelger-Huet Anomaly	4.2%
226	Werner Syndrome	4.2%
227	Myasthenic Syndromes, Congenital	4.2%
228	Congenital diaphragmatic hernia	4.1%
229	Anencephaly	4%
230	Anemia, Sickle Cell	3.9%
231	Thalassemia	3.9%
232	Muscular Dystrophy, Duchenne	3.8%
233	Polycystic Kidney Diseases	3.8%
234	Williams Syndrome	3.8%
235	Albinism	3.7%
236	Smith-Lemli-Opitz Syndrome	3.7%
237	Urogenital Abnormalities	3.6%
238	Dwarfism	3.6%
239	Retinal Dysplasia	3.5%
240	Aniridia	3.4%
241	Fetal Growth Retardation	3.4%
242	Familial Mediterranean Fever	3.4%
243	Prune Belly Syndrome	3.4%
244	Twins, Conjoined	3.4%
245	Waardenburg Syndrome	3.4%
246	Muscular Dystrophy	3.4%
247	Osteogenesis Imperfecta	3.4%
248	Fetal Hypoxia	3.4%
249	Fetal Alcohol Spectrum Disorders	3.4%
250	Maxillofacial Abnormalities	3.4%
251	Dural Arteriovenous Fistula	3.4%
252	Epidermolysis Bullosa	3.4%
253	Dextrocardia	3.4%
254	Rett Syndrome	3.3%
255	Mucopolysaccharidosis II	3.3%
256	Classical Lissencephalies and Subcortical Band Heterotopias	3.2%
257	Kallmann Syndrome	3.2%
258	Menkes Kinky Hair Syndrome	3%
259	Tuberous Sclerosis	3%
260	Wiskott-Aldrich Syndrome	3%
261	Autoimmune Lymphoproliferative Syndrome	3%
262	Chorioamnionitis	2.9%
263	Angioedemas, Hereditary	2.9%
264	Sickle Cell Trait	2.8%
265	Polycystic Kidney, Autosomal Dominant	2.8%
266	Refsum Disease	2.8%
267	Anophthalmos	2.8%
268	Anus, Imperforate	2.8%
269	Hydranencephaly	2.8%
270	Microphthalmos	2.8%
271	Neural Tube Defects	2.8%
272	Tethered Cord Syndrome	2.8%
273	Iniencephaly	2.8%
274	Craniorachischisis	2.8%
275	Limb Deformities, Congenital	2.8%
276	Exencephaly	2.8%
277	Septo-Optic Dysplasia	2.8%
278	Craniofacial Abnormalities	2.8%
279	Cortical Dysplasia	2.8%
280	Malformations of Cortical Development	2.8%
281	Anorectal Malformations	2.8%
282	Amino Acid Metabolism, Inborn Errors	2.7%
283	Bloom Syndrome	2.7%
284	Carbohydrate Metabolism, Inborn Errors	2.7%
285	Metal Metabolism, Inborn Errors	2.7%
286	Progeria	2.7%
287	Lysosomal Storage Diseases	2.7%
288	Cytochrome-c Oxidase Deficiency	2.7%
289	Peroxisomal Disorders	2.7%
290	Pseudoxanthoma Elasticum	2.7%
291	Neuronal Ceroid-Lipofuscinoses	2.7%
292	Myotonic Dystrophy	2.7%
293	Turner Syndrome	2.7%
294	Microcephaly	2.6%
295	Macrocephaly	2.6%
296	Zellweger Syndrome	2.6%
297	Abnormalities, Radiation-Induced	2.5%
298	Craniosynostosis	2.5%
299	Syndactyly	2.5%
300	Brachycephaly	2.5%
301	Acrocephalosyndactylia	2.5%
302	Charcot-Marie-Tooth Disease	2.5%
303	Antley-Bixler Syndrome Phenotype	2.5%
304	Adrenoleukodystrophy	2.5%
305	Xeroderma Pigmentosum	2.5%
306	Klinefelter Syndrome	2.5%
307	Hepatolenticular Degeneration	2.4%
308	Porencephaly	2.4%
309	Blepharophimosis	2.3%
310	Mouth Abnormalities	2.3%
311	Amyloid Neuropathies, Familial	2.3%
312	Fabry Disease	2.3%
313	Cutis Laxa	2.3%
314	Esophageal Atresia	2.3%
315	Intestinal Atresia	2.3%
316	Horseshoe Kidney	2.3%
317	Pectus excavatum	2.3%
318	Klippel-Feil Syndrome	2.3%
319	Retinitis Pigmentosa	2.3%
320	Gastroschisis	2.3%
321	Synostosis	2.3%
322	Pigmentary retinopathy	2.3%
323	Acrodermatitis	2.3%
324	Lymphangiectasis, Intestinal	2.3%
325	Porokeratosis	2.3%
326	Gianotti-Crosti Syndrome	2.3%
327	Keratoderma, Palmoplantar	2.3%
328	Chronic granulomatous disease	2.3%
329	Noonan Syndrome	2.3%
330	Welander Distal Myopathy	2.2%
331	Basal Cell Nevus Syndrome	2.2%
332	Glycogen storage disease type II	2.2%
333	Galactosemias	2.2%
334	Urea Cycle Disorders, Inborn	2.2%
335	Tyrosinemias	2.2%
336	Hydrops Fetalis	2.2%
337	Cleft Palate	2.1%
338	Jaw Abnormalities	2.1%
339	Poland Syndrome	2.1%
340	Mucopolysaccharidosis III	2.1%
341	Ataxia Telangiectasia	2%
342	Amelia	2%
343	Arachnodactyly	2%
344	Ectopia Cordis	2%
345	Ectromelia	2%
346	Hemimelia	2%
347	Meningomyelocele	2%
348	Phocomelia	2%
349	Sirenomelia	2%
350	Spina Bifida	2%
351	Polydactyly	2%
352	Brachydactyly	2%
353	Plagiocephaly	2%
354	Lower Extremity Deformities, Congenital	2%
355	Upper Extremity Deformities, Congenital	2%
356	Single umbilical artery	2%
357	Alkaptonuria	2%
358	Glycogen Storage Disease	2%
359	Hypophosphatasia	2%
360	Propionic acidemia	2%
361	Dihydropyrimidine Dehydrogenase Deficiency	2%
362	Cystinosis	2%
363	Arthrogryposis	2%
364	Optic Atrophy, Hereditary, Leber	2%
365	Choledochal Cyst	2%
366	Duane Retraction Syndrome	2%
367	Hermaphroditism	2%
368	Disorders of Sex Development	2%
369	Hyperphosphaturia	2%
370	Cryptorchidism	2%
371	Porphyrias, Hepatic	2%
372	Hypospadias	2%
373	Central Nervous System Cysts	2%
374	Canavan Disease	1.9%
375	Alexander Disease	1.9%
376	Dandy-Walker Syndrome	1.9%
377	Peutz-Jeghers Syndrome	1.9%
378	Myotonia Congenita	1.9%
379	Thrombasthenia	1.9%
380	Antithrombin III Deficiency	1.9%
381	Protein C Deficiency	1.9%
382	Brain Diseases, Metabolic, Inborn	1.9%
383	Afibrinogenemia	1.9%
384	Dystonia Musculorum Deformans	1.9%
385	Factor VII Deficiency	1.9%
386	Factor X Deficiency	1.9%
387	Factor XII Deficiency	1.9%
388	Hemophilia A	1.9%
389	POEMS Syndrome	1.9%
390	Activated Protein C Resistance	1.9%
391	Factor II deficiency	1.9%
392	Factor VIII Deficiency	1.9%
393	Factor V deficiency	1.9%
394	Factor XI Deficiency	1.9%
395	Hypoprothrombinemias	1.9%
396	Fanconi Anemia	1.9%
397	Lafora Disease	1.9%
398	Unverricht-Lundborg Syndrome	1.9%
399	Anemia, Diamond-Blackfan	1.9%
400	Homocystinuria	1.8%
401	Gaucher Disease	1.8%
402	Leigh Disease	1.8%
403	Micrognathism	1.7%
404	Pierre Robin Syndrome	1.7%
405	Multiple Endocrine Neoplasia	1.7%
406	Pectus carinatum	1.7%
407	Bladder Exstrophy	1.7%
408	Congenital Hypothyroidism	1.7%
409	Epispadias	1.7%
410	Aortic coarctation	1.7%
411	Cor Triatriatum	1.7%
412	Coronary Vessel Anomalies	1.7%
413	Dental Enamel Hypoplasia	1.7%
414	Dermatitis, Atopic	1.7%
415	Patent ductus arteriosus	1.7%
416	Ebstein Anomaly	1.7%
417	Heart Septal Defects	1.7%
418	Hypodontia	1.7%
419	Macrostomia	1.7%
420	Meningocele	1.7%
421	Microstomia	1.7%
422	Tetralogy of Fallot	1.7%
423	Transposition of Great Vessels	1.7%
424	Hypoplastic Left Heart Syndrome	1.7%
425	May-Thurner Syndrome	1.7%
426	Encephalocele	1.7%
427	Multicystic Dysplastic Kidney	1.7%
428	Craniofacial Dysostosis	1.7%
429	Dermal Sinus	1.7%
430	Spina Bifida Cystica	1.7%
431	Spina Bifida Occulta	1.7%
432	Lissencephaly	1.7%
433	Polymicrogyria	1.7%
434	Pachygyria	1.7%
435	Schizencephaly	1.7%
436	Periventricular Nodular Heterotopia	1.7%
437	Glycogen Storage Disease Type I	1.7%
438	Glycogen Storage Disease Type V	1.7%
439	Hypolipoproteinemias	1.7%
440	Papillon-Lefevre Disease	1.7%
441	Wolff-Parkinson-White Syndrome	1.7%
442	Hyperlipidemia, Familial Combined	1.7%
443	Hyperlipoproteinemia Type III	1.7%
444	Tay-Sachs Disease	1.7%
445	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.6%
446	Niemann-Pick Disease, Type C	1.6%
447	Retrognathia	1.6%
448	Behcet Syndrome	1.5%
449	Hyperandrogenism	1.5%
450	Familial Periodic Paralysis	1.5%
451	Long QT Syndrome	1.4%
452	Platybasia	1.4%
453	Tricuspid Atresia	1.4%
454	Arrhythmogenic Right Ventricular Dysplasia	1.4%
455	Gonadal Dysgenesis	1.4%
456	Adrenogenital Syndrome	1.4%
457	Ovotesticular Disorders of Sex Development	1.4%
458	Lactose Intolerance	1.4%
459	Variegate Porphyria	1.4%
460	Acute intermittent porphyria	1.4%
461	Porphyria Cutanea Tarda	1.4%
462	Prognathism	1.4%
463	Hyperhomocysteinemia	1.4%
464	Renal Aminoacidurias	1.4%
465	Fanconi Syndrome	1.4%
466	Pseudohypoaldosteronism	1.4%
467	Liddle Syndrome	1.4%
468	Hyperlipoproteinemia Type IV	1.4%
469	Hyperlipoproteinemia Type V	1.4%
470	Aortopulmonary Septal Defect	1.4%
471	Double Outlet Right Ventricle	1.4%
472	Endocardial Cushion Defects	1.4%
473	Myocardial bridging	1.4%
474	Aorticopulmonary Septal Defect	1.4%
475	Hypoalphalipoproteinemias	1.4%
476	Huntington Disease	1.3%
477	Gout	1.3%
478	Multiple Endocrine Neoplasia Type 1	1.3%
479	Pseudohypoparathyroidism	1.3%
480	Friedreich Ataxia	1.2%
481	Truncus Arteriosus, Persistent	1.2%
482	Goldenhar Syndrome	1.2%
483	Renal tubular acidosis	1.2%
484	Nephroblastoma	1.2%
485	Denys-Drash Syndrome	1.2%
486	Hypokalemic periodic paralysis	1.2%
487	Mandibulofacial Dysostosis	1.2%
488	Romano-Ward Syndrome	1.2%
489	Cystinuria	1.2%
490	Adenomatous Polyposis Coli	1.1%
491	Familial Hypophosphatemic Rickets	1.1%
492	Talipes	1.1%
493	Arthritis, Gouty	1%
494	Congenital clubfoot	1%
495	Vertical Talus	1%
496	Glycosuria, Renal	1%
497	Arteriovenous fistula	0.9%
498	MELAS Syndrome	0.8%

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