MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Vertical Talus

(UMLS:C0240912)

Definition:: Congenital severe form of flatfoot involving dislocation of the NAVICULAR BONE OF FOOT on the TALUS.
UMLS ID:: C0240912
MeSH ID:: D005413

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.330.488.655.250|C05.330.495.681.250|C05.660.585.512.380.813.250

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.585.512.500.681.250

Synonym(s)

Vertical Talus

CCPV - Congenital convex pes valgus

CVT - Congenital vertical talus

Congenital convex pes valgus

Congenital vertical talus

Convex pes valgus

Rocker bottom feet

Rocker bottom foot

Rocker-bottom feet

10.

Rockerbottom feet

11.

VERTICAL TALUS, CONGENITAL

12.

Vertical talus

13.

congenital convex pes valgus

14.

congenital vertical talus

15.

feet pes rockerbottom foot

16.

rocker bottom feet

17.

rocker bottom foot

18.

rockerbottom foot

19.

vertical talus

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Ritonavir	FAERS: 4	US FAERS
2	Fluoxetine	FAERS: 2	US FAERS
3	Citalopram	FAERS: 1	US FAERS
4	Paroxetine	FAERS: 1	US FAERS
5	Valproic Acid	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Congenital clubfoot	55.8%
2	Arthrogryposis	27.6%
3	Syndactyly	22.6%
4	Pectus carinatum	22.1%
5	Pectus excavatum	21.5%
6	Bunion	20.7%
7	Amelia	20.7%
8	Arachnodactyly	20.7%
9	Ectromelia	20.7%
10	Hemimelia	20.7%
11	Phocomelia	20.7%
12	Sirenomelia	20.7%
13	Polydactyly	20.7%
14	Brachydactyly	20.7%
15	Upper Extremity Deformities, Congenital	20.7%
16	Craniofacial Abnormalities	20.5%
17	Klippel-Feil Syndrome	20%
18	Synostosis	20%
19	Bone Diseases	17.5%
20	Fasciitis	17.5%
21	Arthropathy	17.5%
22	Gastroschisis	17.5%
23	Craniosynostosis	16.1%
24	Brachycephaly	16.1%
25	Contracture	15.7%
26	Osteoarthropathy, Secondary Hypertrophic	15.7%
27	Fasciitis, Plantar	15.7%
28	Jaw Diseases	15.1%
29	Platybasia	15.1%
30	Cartilage Diseases	14.8%
31	Foot Diseases	14.8%
32	Myopathy	14.8%
33	Rheumatism	14.8%
34	Chondromalacia	14.8%
35	Acrocephalosyndactylia	14.7%
36	Fibromyalgia	13.5%
37	Osteochondritis	13.5%
38	Polymyalgia Rheumatica	13.5%
39	Metatarsalgia	13.4%
40	Poland Syndrome	13.2%
41	Rubinstein-Taybi Syndrome	12%
42	Craniofacial Dysostosis	11.9%
43	Gout	11.6%
44	Holoprosencephaly	11.5%
45	Plagiocephaly	11.1%
46	Maxillofacial Abnormalities	11%
47	Laryngomalacia	10.8%
48	Rheumatic Fever	10.5%
49	Temporomandibular Joint Disorders	10.3%
50	Talipes	10.2%
51	Nail-Patella Syndrome	10.2%
52	Ischemic contracture	10.1%
53	Jaw Abnormalities	9.8%
54	Rheumatoid Arthritis	9.3%
55	Juvenile arthritis	9.3%
56	Arthritis	9.3%
57	Bone Diseases, Developmental	9.3%
58	Bursitis	9.3%
59	Hyperostosis	9.3%
60	Joint Instability	9.3%
61	Myofascial Pain Syndromes	9.3%
62	Osteitis	9.3%
63	Osteitis Deformans	9.3%
64	Osteochondrosis	9.3%
65	Rhabdomyolysis	9.3%
66	Spinal Diseases	9.3%
67	Synovitis	9.3%
68	Joint laxity	9.3%
69	Polyarthritis	9.3%
70	Frozen shoulder	9.3%
71	Patellofemoral Pain Syndrome	9.3%
72	Antley-Bixler Syndrome Phenotype	9.1%
73	Microcephaly	9%
74	Macrocephaly	9%
75	Osteoarthritis, Spine	9%
76	Hip Contracture	8.9%
77	Periarthritis	8.9%
78	Temporomandibular Joint Dysfunction Syndrome	8.3%
79	Abnormalities, Drug-Induced	8.1%
80	Situs Inversus	8.1%
81	Bone Diseases, Endocrine	8%
82	Noonan Syndrome	7.9%
83	Bone Diseases, Infectious	7.8%
84	Bone neoplasms	7.8%
85	Compartment syndromes	7.8%
86	Maxillary Diseases	7.8%
87	Osteopenia	7.8%
88	Tendinitis	7.8%
89	Tendinopathy	7.8%
90	Bone Resorption	7.8%
91	Hemarthrosis	7.8%
92	Myositis	7.8%
93	Tietze's Syndrome	7.8%
94	Isaacs syndrome	7.8%
95	Aseptic Necrosis of Bone	7.8%
96	Myotonic Disorders	7.8%
97	Gigantism	7.7%
98	Spinal Neoplasms	7.7%
99	Spondylitis	7.7%
100	Osteoarthritis, Knee	7.2%
101	Prognathism	7.1%
102	Eye Abnormalities	7%
103	Cardiovascular Abnormalities	7%
104	Arthritis, Gouty	6.9%
105	Beckwith-Wiedemann Syndrome	6.9%
106	Wolf-Hirschhorn Syndrome	6.9%
107	Ankylosing spondylitis	6.9%
108	Skin Abnormalities	6.8%
109	Lymphatic Abnormalities	6.8%
110	Congenital Microtia	6.8%
111	Vertical Talus	6.8%
112	Multiple Epiphyseal Dysplasia	6.7%
113	Osteochondrodysplasias	6.7%
114	Medial Tibial Stress Syndrome	6.7%
115	Congenital diaphragmatic hernia	6.7%
116	Mitochondrial Myopathies	6.7%
117	Marfan Syndrome	6.7%
118	Muscle Cramp	6.6%
119	Eosinophilia-Myalgia Syndrome	6.6%
120	Aicardi's syndrome	6.6%
121	Muscle Rigidity	6.6%
122	Muscle Spasticity	6.6%
123	Cogwheel Rigidity	6.6%
124	Nuchal Rigidity	6.6%
125	Bronchomalacia	6.5%
126	Tracheomalacia	6.5%
127	Mandibulofacial Dysostosis	6.4%
128	Familial Periodic Paralysis	6.3%
129	Rheumatoid Nodule	6.2%
130	Smith-Magenis syndrome	6.1%
131	Chronic Fatigue Syndrome	6%
132	Cri-du-Chat Syndrome	6%
133	Down Syndrome	6%
134	Trisomy 21	6%
135	Urogenital Abnormalities	6%
136	Arthritis, Psoriatic	6%
137	Dwarfism	6%
138	Giant Cell Epulis	5.9%
139	Muscle Weakness	5.9%
140	Musculoskeletal Pain	5.8%
141	Micrognathism	5.8%
142	Pierre Robin Syndrome	5.8%
143	Arthralgia	5.8%
144	Polyarthralgia	5.8%
145	Muscular Dystrophy	5.8%
146	Congenital Hypothyroidism	5.7%
147	Porencephaly	5.6%
148	Foot Deformities	5.5%
149	Basal Cell Nevus Syndrome	5.5%
150	Felty Syndrome	5.5%
151	Limb Deformities, Congenital	5.4%
152	Genetic Diseases, Inborn	5.4%
153	Ectodermal Dysplasia	5.4%
154	Aplasia Cutis Congenita	5.4%
155	Prader-Willi Syndrome	5.4%
156	Cleft Palate	5.3%
157	Ainhum	5.3%
158	Dysostoses	5.3%
159	Fibrodysplasia Ossificans Progressiva	5.3%
160	Myoglobinuria	5.3%
161	Myositis Ossificans	5.3%
162	Spinal Stenosis	5.3%
163	Spondylosis	5.3%
164	Tenosynovitis	5.3%
165	Intervertebral Disc Degeneration	5.3%
166	Sacroiliitis	5.3%
167	Retrognathia	5.3%
168	Myotonic Dystrophy	5.2%
169	Cockayne Syndrome	5.2%
170	Eosinophilic Granuloma	5.2%
171	Myalgia	5.1%
172	Goldenhar Syndrome	4.9%
173	CHARGE Syndrome	4.9%
174	Rheumatoid Vasculitis	4.8%
175	Discitis	4.8%
176	Arthritis, Reactive	4.8%
177	Spondylarthropathies	4.8%
178	Fetal Diseases	4.6%
179	Anencephaly	4.5%
180	Arthritis, Infectious	4.5%
181	Abnormalities, Radiation-Induced	4.5%
182	Anterior Compartment Syndrome	4.4%
183	Osteomyelitis	4.4%
184	Osteoporosis	4.4%
185	Periostitis	4.4%
186	Enthesopathy	4.4%
187	Bone Demineralization, Pathologic	4.4%
188	Post-Traumatic Osteoporosis	4.4%
189	Arthritis, Experimental	4.4%
190	Abdominal Compartment Syndrome	4.4%
191	Alveolar Bone Loss	4.4%
192	Femur Head Necrosis	4.4%
193	Polymyositis	4.4%
194	Osteolysis	4.4%
195	Sicca Syndrome	4.4%
196	Sjogren's Syndrome	4.4%
197	Osteogenesis Imperfecta	4.4%
198	Xeroderma	4.3%
199	Mobius Syndrome	4.3%
200	Myotonia Congenita	4.2%
201	Tuberculosis, Spinal	4.2%
202	Prune Belly Syndrome	4.1%
203	Twins, Conjoined	4.1%
204	Waardenburg Syndrome	4.1%
205	Dural Arteriovenous Fistula	4%
206	Dextrocardia	4%
207	Hip Dislocation	3.9%
208	Shoulder Dislocation	3.9%
209	Hip Dysplasia	3.9%
210	Palatal Neoplasms	3.9%
211	Kartagener Syndrome	3.9%
212	Orbital Myositis	3.8%
213	Dupuytren Contracture	3.8%
214	Muscular Dystrophy, Duchenne	3.8%
215	Pyomyositis	3.8%
216	Acromegaly	3.8%
217	Joint Tuberculosis	3.8%
218	Tuberculosis, Osteoarticular	3.8%
219	Bone Tuberculosis	3.8%
220	Hypokalemic periodic paralysis	3.6%
221	Cystic Fibrosis	3.5%
222	Anophthalmos	3.5%
223	Anus, Imperforate	3.5%
224	Hydranencephaly	3.5%
225	Microphthalmos	3.5%
226	Neural Tube Defects	3.5%
227	Tethered Cord Syndrome	3.5%
228	Iniencephaly	3.5%
229	Craniorachischisis	3.5%
230	Exencephaly	3.5%
231	Septo-Optic Dysplasia	3.5%
232	Cortical Dysplasia	3.5%
233	Malformations of Cortical Development	3.5%
234	Anorectal Malformations	3.5%
235	Bloom Syndrome	3.4%
236	Polycystic Kidney Diseases	3.4%
237	Williams Syndrome	3.4%
238	Welander Distal Myopathy	3.4%
239	Pseudohypoparathyroidism	3.4%
240	Chondrodysplasia Punctata	3.4%
241	Enchondromatosis	3.4%
242	Lordosis	3.4%
243	Osteosclerosis	3.4%
244	Spondylolysis	3.4%
245	kyphosis	3.4%
246	Kashin-Beck Disease	3.4%
247	Rickets	3.3%
248	Shoulder Pain	3.3%
249	Scimitar Syndrome	3.2%
250	Lower Extremity Deformities, Congenital	3.2%
251	Retinal Dysplasia	3.2%
252	Aniridia	3.1%
253	Epidermolysis Bullosa	3.1%
254	Meconium Aspiration Syndrome	3.1%
255	Blepharophimosis	3%
256	Laryngostenosis	3%
257	Mouth Abnormalities	3%
258	Esophageal Atresia	3%
259	Intestinal Atresia	3%
260	Horseshoe Kidney	3%
261	Mitochondrial Encephalomyopathies	3%
262	Acrodermatitis	3%
263	Lymphangiectasis, Intestinal	3%
264	Gianotti-Crosti Syndrome	3%
265	Osteoporosis, Postmenopausal	2.8%
266	Smith-Lemli-Opitz Syndrome	2.8%
267	Alstrom Syndrome	2.8%
268	Ichthyosis, X-Linked	2.7%
269	Abdominal Cramps	2.7%
270	Amniotic Band Syndrome	2.7%
271	Asphyxia Neonatorum	2.7%
272	Infant, Premature, Diseases	2.7%
273	Infantile Colic	2.7%
274	Choanal Atresia	2.7%
275	Tracheobronchomegaly	2.7%
276	Laryngocele	2.7%
277	Choledochal Cyst	2.6%
278	Hermaphroditism	2.6%
279	Disorders of Sex Development	2.6%
280	Cryptorchidism	2.6%
281	Hypospadias	2.6%
282	Central Nervous System Cysts	2.6%
283	Dandy-Walker Syndrome	2.6%
284	POEMS Syndrome	2.6%
285	Pseudoxanthoma Elasticum	2.5%
286	Mastoiditis	2.4%
287	Petrositis	2.4%
288	Fragile X Syndrome	2.4%
289	Melorheostosis	2.4%
290	Osteopetrosis	2.4%
291	Spondylolisthesis	2.4%
292	Primary Ciliary Dyskinesia	2.3%
293	Xeroderma Pigmentosum	2.3%
294	Neoplastic Syndromes, Hereditary	2.3%
295	Bladder Exstrophy	2.3%
296	Epispadias	2.3%
297	Multicystic Dysplastic Kidney	2.3%
298	Anemia, Neonatal	2.2%
299	Pelger-Huet Anomaly	2.2%
300	Persistent Fetal Circulation Syndrome	2.2%
301	Werner Syndrome	2.2%
302	Myasthenic Syndromes, Congenital	2.2%
303	Umbilical hernia	2.2%
304	Dermatomyositis	2.2%
305	Osteomalacia	2.1%
306	Sjogren-Larsson Syndrome	2%
307	Zellweger Syndrome	2%
308	Neonatal Abstinence Syndrome	2%
309	Kallmann Syndrome	1.9%
310	Fetal Growth Retardation	1.9%
311	Fetal Hypoxia	1.9%
312	Congenital nystagmus	1.9%
313	Fetal Alcohol Spectrum Disorders	1.9%
314	Toxoplasmosis, Congenital	1.9%
315	Syphilis, Congenital	1.9%
316	Turner Syndrome	1.8%
317	Ectopia Cordis	1.8%
318	Meningomyelocele	1.8%
319	Spina Bifida	1.8%
320	Single umbilical artery	1.8%
321	Polycystic Kidney, Autosomal Dominant	1.8%
322	Anemia, Sickle Cell	1.7%
323	Thalassemia	1.7%
324	Autoimmune Lymphoproliferative Syndrome	1.7%
325	Congenital Hyperinsulinism	1.7%
326	Chorioamnionitis	1.7%
327	Angioedemas, Hereditary	1.7%
328	Charcot-Marie-Tooth Disease	1.6%
329	Albinism	1.6%
330	Nose Neoplasms	1.6%
331	Tuberous Sclerosis	1.6%
332	MELAS Syndrome	1.6%
333	Aortic coarctation	1.6%
334	Cor Triatriatum	1.6%
335	Coronary Vessel Anomalies	1.6%
336	Dental Enamel Hypoplasia	1.6%
337	Patent ductus arteriosus	1.6%
338	Ebstein Anomaly	1.6%
339	Heart Septal Defects	1.6%
340	Hypodontia	1.6%
341	Macrostomia	1.6%
342	Meningocele	1.6%
343	Microstomia	1.6%
344	Tetralogy of Fallot	1.6%
345	Transposition of Great Vessels	1.6%
346	Hypoplastic Left Heart Syndrome	1.6%
347	May-Thurner Syndrome	1.6%
348	Encephalocele	1.6%
349	Wolff-Parkinson-White Syndrome	1.5%
350	Renal Osteodystrophy	1.5%
351	Renal rickets	1.5%
352	Classical Lissencephalies and Subcortical Band Heterotopias	1.5%
353	Refsum Disease	1.4%
354	Wiskott-Aldrich Syndrome	1.4%
355	Long QT Syndrome	1.4%
356	Tricuspid Atresia	1.4%
357	Arrhythmogenic Right Ventricular Dysplasia	1.4%
358	Familial Mediterranean Fever	1.4%
359	Gonadal Dysgenesis	1.4%
360	Adrenogenital Syndrome	1.4%
361	Ovotesticular Disorders of Sex Development	1.4%
362	Radicular Cyst	1.3%
363	Ophthalmia Neonatorum	1.3%
364	Hyperkeratosis, Epidermolytic	1.3%
365	Klinefelter Syndrome	1.3%
366	Ataxia Telangiectasia	1.2%
367	Kearns-Sayre syndrome	1.2%
368	Paralysis, Obstetric	1.2%
369	Retinopathy of Prematurity	1.2%
370	Amino Acid Metabolism, Inborn Errors	1.1%
371	Carbohydrate Metabolism, Inborn Errors	1.1%
372	Metal Metabolism, Inborn Errors	1.1%
373	Progeria	1.1%
374	Lysosomal Storage Diseases	1.1%
375	Cytochrome-c Oxidase Deficiency	1.1%
376	Peroxisomal Disorders	1.1%
377	Bronchopulmonary Dysplasia	1.1%
378	Menkes Kinky Hair Syndrome	1%
379	Rett Syndrome	1%
380	Respiratory Distress Syndrome, Newborn	1%
381	Hyperandrogenism	1%
382	Dermal Sinus	1%
383	Spina Bifida Cystica	1%
384	Spina Bifida Occulta	1%
385	Lissencephaly	1%
386	Polymicrogyria	1%
387	Pachygyria	1%
388	Schizencephaly	1%
389	Periventricular Nodular Heterotopia	1%
390	Cutis Laxa	1%
391	Familial Hypophosphatemic Rickets	1%
392	Retinitis Pigmentosa	1%
393	Pigmentary retinopathy	1%
394	Porokeratosis	1%
395	Keratoderma, Palmoplantar	1%
396	Neuronal Ceroid-Lipofuscinoses	1%
397	Chronic granulomatous disease	1%
398	Amyloid Neuropathies, Familial	1%
399	Hepatolenticular Degeneration	0.9%
400	Mucopolysaccharidosis II	0.9%
401	Sickle Cell Trait	0.9%
402	Duane Retraction Syndrome	0.9%
403	Porphyrias, Hepatic	0.9%
404	Peutz-Jeghers Syndrome	0.9%
405	Thrombasthenia	0.9%
406	Antithrombin III Deficiency	0.9%
407	Protein C Deficiency	0.9%
408	Brain Diseases, Metabolic, Inborn	0.9%
409	Afibrinogenemia	0.9%
410	Dystonia Musculorum Deformans	0.9%
411	Factor VII Deficiency	0.9%
412	Factor X Deficiency	0.9%
413	Factor XII Deficiency	0.9%
414	Hemophilia A	0.9%
415	Leukomalacia, Periventricular	0.9%
416	Activated Protein C Resistance	0.9%
417	Factor II deficiency	0.9%
418	Factor VIII Deficiency	0.9%
419	Factor V deficiency	0.9%
420	Factor XI Deficiency	0.9%
421	Hypoprothrombinemias	0.9%
422	Aortopulmonary Septal Defect	0.9%
423	Double Outlet Right Ventricle	0.9%
424	Endocardial Cushion Defects	0.9%
425	Myocardial bridging	0.9%
426	Aorticopulmonary Septal Defect	0.9%
427	Fanconi Anemia	0.9%
428	Nesidioblastosis	0.9%
429	Lafora Disease	0.9%
430	Unverricht-Lundborg Syndrome	0.9%
431	Anemia, Diamond-Blackfan	0.9%
432	Adrenoleukodystrophy	0.8%
433	Hydrops Fetalis	0.8%
434	Multiple Endocrine Neoplasia	0.8%
435	Dermatitis, Atopic	0.8%
436	Romano-Ward Syndrome	0.7%
437	Canavan Disease	0.7%
438	Alexander Disease	0.7%
439	Acute Chest Syndrome	0.7%
440	Galactosemias	0.7%
441	Urea Cycle Disorders, Inborn	0.7%
442	Tyrosinemias	0.7%
443	Kernicterus	0.7%
444	Behcet Syndrome	0.7%
445	Optic Atrophy, Hereditary, Leber	0.7%
446	Hyperphosphaturia	0.7%
447	Fabry Disease	0.6%
448	Huntington Disease	0.6%
449	Arteriovenous fistula	0.6%
450	Alkaptonuria	0.6%
451	Glycogen Storage Disease	0.6%
452	Hypophosphatasia	0.6%
453	Propionic acidemia	0.6%
454	Dihydropyrimidine Dehydrogenase Deficiency	0.6%
455	Cystinosis	0.6%
456	Denys-Drash Syndrome	0.6%
457	Nephroblastoma	0.6%
458	Adenomatous Polyposis Coli	0.5%
459	Hyaline Membrane Disease	0.5%
460	Hypolipoproteinemias	0.5%
461	Papillon-Lefevre Disease	0.5%
462	Hyperlipidemia, Familial Combined	0.5%
463	Homocystinuria	0.5%
464	Hyperlipoproteinemia Type III	0.5%
465	Truncus Arteriosus, Persistent	0.5%
466	Leigh Disease	0.5%
467	Glycogen storage disease type II	0.5%
468	Lactose Intolerance	0.5%
469	Variegate Porphyria	0.5%
470	Acute intermittent porphyria	0.5%
471	Porphyria Cutanea Tarda	0.5%
472	Hyperhomocysteinemia	0.5%
473	Renal Aminoacidurias	0.4%
474	Fanconi Syndrome	0.4%
475	Pseudohypoaldosteronism	0.4%
476	Liddle Syndrome	0.4%
477	Hyperlipoproteinemia Type IV	0.4%
478	Hyperlipoproteinemia Type V	0.4%
479	Mucopolysaccharidosis III	0.4%
480	Multiple Endocrine Neoplasia Type 1	0.4%
481	Friedreich Ataxia	0.4%
482	Renal tubular acidosis	0.4%
483	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.4%
484	Glycogen Storage Disease Type I	0.3%
485	Glycogen Storage Disease Type V	0.3%
486	Glycosuria, Renal	0.3%
487	Hypoalphalipoproteinemias	0.3%
488	Gaucher Disease	0.3%
489	Cystinuria	0.2%
490	Niemann-Pick Disease, Type C	0.2%
491	Tay-Sachs Disease	0.1%

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