MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Myotonia Congenita

(UMLS:C0027127)

Definition:: Inherited myotonic disorders with early childhood onset MYOTONIA. Muscular hypertrophy is common and myotonia may impair ambulation and other movements. It is classified as Thomsen (autosomal dominant) or Becker (autosomal recessive) generalized myotonia mainly based on the inheritance pattern. Becker type is also clinically more severe. An autosomal dominant variant with milder symptoms and later onset is known as myotonia levior. Mutations in the voltage-dependent skeletal muscle chloride channel are associated with the disorders.
UMLS ID:: C0027127
MeSH ID:: D009224

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.662.500

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.574.500.545|C10.668.491.606.500

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.400.540

Synonym(s)

Myotonia Congenita

MYOPATHY, CONGENITAL

MYOTONIA CONGENITA

Myotonia congenita

congenita; myotonia

congenital myotonia

myotonia; congenita

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acetazolamide	11985388	CTD
2	Carbamazepine	20399394	CTD
3	Nizatidine		OFFSIDES
4	Phenytoin	1896199	CTD
5	Quinine	1896199	CTD
6	Succinylcholine		OFFSIDES
7	Tocainide	3087270	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Myotonic Dystrophy	46%
2	Dystonia Musculorum Deformans	28.4%
3	Lafora Disease	26.8%
4	Unverricht-Lundborg Syndrome	26.8%
5	Cockayne Syndrome	25.8%
6	Motor Neuron Disease	24.9%
7	Neuronal Ceroid-Lipofuscinoses	24.2%
8	Myositis	24%
9	Fibromyalgia	23.7%
10	Tuberous Sclerosis	23.2%
11	Amyloid Neuropathies, Familial	22.8%
12	Muscular Dystrophy	22.4%
13	Charcot-Marie-Tooth Disease	22.1%
14	Canavan Disease	22%
15	Alexander Disease	22%
16	Huntington Disease	21.8%
17	Familial Periodic Paralysis	21.6%
18	Alstrom Syndrome	21.4%
19	Medial Tibial Stress Syndrome	20.8%
20	Mitochondrial Myopathies	20.6%
21	Eosinophilia-Myalgia Syndrome	20.5%
22	Hepatolenticular Degeneration	20.4%
23	Chronic Fatigue Syndrome	19.9%
24	Friedreich Ataxia	19.2%
25	Muscular Dystrophy, Duchenne	18.9%
26	Amyotrophic Lateral Sclerosis	18.4%
27	Refsum Disease	18%
28	Multiple System Atrophy	17.5%
29	Isaacs syndrome	17.3%
30	Myasthenic Syndromes, Congenital	17.3%
31	Optic Atrophy, Hereditary, Leber	16.9%
32	Prion Diseases	16.8%
33	Fragile X Syndrome	16.6%
34	Spinal Muscular Atrophy	16.6%
35	Progressive Muscular Atrophy	16.6%
36	Stiff-Person Syndrome	16.5%
37	Polymyositis	15.9%
38	Welander Distal Myopathy	15.9%
39	Rett Syndrome	15.9%
40	Myalgia	15.8%
41	Progressive bulbar palsy	15.5%
42	Bulbar palsy	15.5%
43	Tauopathies	15.4%
44	Subacute Combined Degeneration	15.2%
45	Parkinson Disease	15.1%
46	Hypokalemic periodic paralysis	14.9%
47	Arthrogryposis	14.5%
48	Neuromuscular Junction Diseases	14.1%
49	Peripheral Nervous System Diseases	14.1%
50	Orbital Myositis	13.8%
51	Pyomyositis	13.7%
52	Lewy Body Disease	13.6%
53	Contracture	13.6%
54	Aicardi's syndrome	13.4%
55	Complex Regional Pain Syndromes	13.4%
56	Mucopolysaccharidosis II	13.2%
57	Cranial nerve diseases	13.1%
58	Demyelinating Diseases	13.1%
59	Demyelination	13.1%
60	Chronobiology Disorders	13.1%
61	Polyradiculoneuropathy	13%
62	Polyradiculoneuritis	13%
63	Lambert-Eaton Myasthenic Syndrome	13%
64	Menkes Kinky Hair Syndrome	13%
65	Smith-Magenis syndrome	13%
66	Poliomyelitis	12.8%
67	Adrenoleukodystrophy	12.6%
68	Guillain-Barre Syndrome	12.4%
69	Mitochondrial Encephalomyopathies	12.4%
70	Multiple Epiphyseal Dysplasia	12.3%
71	Osteochondrodysplasias	12.3%
72	Myofascial Pain Syndromes	12.1%
73	Rhabdomyolysis	12.1%
74	Muscle Cramp	11.9%
75	Striatonigral Degeneration	11.9%
76	Nail-Patella Syndrome	11.8%
77	Causalgia	11.7%
78	Ischemic contracture	11.6%
79	Restless Legs Syndrome	11.6%
80	Polymyalgia Rheumatica	11.6%
81	Peripheral Nerve Injuries	11.6%
82	Myasthenia Gravis	11.5%
83	Trauma, Nervous System	11.2%
84	Holoprosencephaly	11.1%
85	Paraneoplastic Encephalomyelitis	11.1%
86	Progressive supranuclear palsy	11%
87	Nervous System Neoplasms	11%
88	Neurologic Manifestations	11%
89	Neurotoxicity Syndromes	11%
90	Ataxia Telangiectasia	11%
91	Ocular Motility Disorders	10.9%
92	Cyclophoria	10.9%
93	Muscle Rigidity	10.9%
94	Muscle Spasticity	10.9%
95	Cogwheel Rigidity	10.9%
96	Nuchal Rigidity	10.9%
97	Dwarfism	10.8%
98	Myelitis, Transverse	10.7%
99	Ophthalmoplegic Migraine	10.7%
100	Shy-Drager Syndrome	10.6%
101	CHARGE Syndrome	10.5%
102	Muscle Weakness	10.5%
103	Rubinstein-Taybi Syndrome	10.5%
104	Neoplastic Syndromes, Hereditary	10.4%
105	Dandy-Walker Syndrome	10.4%
106	Cri-du-Chat Syndrome	10.3%
107	Down Syndrome	10.3%
108	Trisomy 21	10.3%
109	Cystic Fibrosis	10.3%
110	Opsoclonus-Myoclonus Syndrome	10.3%
111	Compartment syndromes	10.2%
112	Tendinitis	10.2%
113	Tendinopathy	10.2%
114	Miller Fisher Syndrome	10.1%
115	Ichthyosis, X-Linked	10.1%
116	Encephalomyelitis	10.1%
117	Pelger-Huet Anomaly	10.1%
118	Werner Syndrome	10.1%
119	Autonomic Dysreflexia	10.1%
120	Botulism	10%
121	Osteogenesis Imperfecta	10%
122	Albinism	9.9%
123	Anemia, Sickle Cell	9.9%
124	Thalassemia	9.9%
125	Meningoencephalitis	9.9%
126	Brachial Plexus Neuritis	9.8%
127	Neuralgic Amyotrophy	9.8%
128	MELAS Syndrome	9.7%
129	Sleep Wake Disorders	9.5%
130	Scrapie	9.5%
131	Beckwith-Wiedemann Syndrome	9.5%
132	Wolf-Hirschhorn Syndrome	9.5%
133	Presenile dementia	9.4%
134	Senile dementia	9.4%
135	Dermatomyositis	9.2%
136	Central Nervous System Cysts	9.2%
137	Prader-Willi Syndrome	9.2%
138	Limbic Encephalitis	9.1%
139	Temporomandibular Joint Dysfunction Syndrome	9.1%
140	Marchiafava-Bignami Disease	8.9%
141	Spinal Cord Injuries	8.9%
142	Marfan Syndrome	8.8%
143	Hip Contracture	8.8%
144	Reflex Sympathetic Dystrophy	8.8%
145	Tarsal Tunnel Syndrome	8.7%
146	Cauda Equina Syndrome	8.7%
147	Pneumocephalus	8.7%
148	Williams Syndrome	8.6%
149	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	8.6%
150	Asterixis	8.6%
151	Ballismus	8.6%
152	Neuritis	8.6%
153	Polyneuritis	8.6%
154	Radiculitis	8.6%
155	Polyneuropathy	8.6%
156	Mononeuritis	8.6%
157	Mononeuropathies	8.6%
158	Brachial Plexus Neuropathies	8.6%
159	Radiculopathy	8.6%
160	Mononeuropathy Multiplex	8.6%
161	Nerve Root Compression	8.6%
162	Leukoencephalitis, Acute Hemorrhagic	8.5%
163	Gout	8.5%
164	Acrodynia	8.4%
165	Hydranencephaly	8.4%
166	Neural Tube Defects	8.4%
167	Tethered Cord Syndrome	8.4%
168	Iniencephaly	8.4%
169	Craniorachischisis	8.4%
170	Exencephaly	8.4%
171	Septo-Optic Dysplasia	8.4%
172	Cortical Dysplasia	8.4%
173	Malformations of Cortical Development	8.4%
174	Paraneoplastic Cerebellar Degeneration	8.2%
175	Classical Lissencephalies and Subcortical Band Heterotopias	8.2%
176	Kartagener Syndrome	8.1%
177	Duane Retraction Syndrome	8%
178	Fibrodysplasia Ossificans Progressiva	7.9%
179	Myoglobinuria	7.9%
180	Myositis Ossificans	7.9%
181	Familial Mediterranean Fever	7.9%
182	Tenosynovitis	7.9%
183	Temporomandibular Joint Disorders	7.9%
184	Fabry Disease	7.9%
185	Neuromyelitis Optica	7.9%
186	Wiskott-Aldrich Syndrome	7.9%
187	Epidural Abscess	7.8%
188	Olfactory Nerve Injuries	7.8%
189	Myelitis	7.7%
190	Sleep Disorders, Circadian Rhythm	7.7%
191	Dyskinesia, Drug-Induced	7.7%
192	MPTP Poisoning	7.6%
193	Neuroleptic Malignant Syndrome	7.6%
194	Myelinolysis, Central Pontine	7.6%
195	Autoimmune Lymphoproliferative Syndrome	7.6%
196	Myasthenia Gravis, Autoimmune, Experimental	7.5%
197	Musculoskeletal Pain	7.5%
198	Dural Arteriovenous Fistula	7.5%
199	Carpal Tunnel Syndrome	7.5%
200	Pectus carinatum	7.5%
201	Sciatica	7.4%
202	Angioedemas, Hereditary	7.4%
203	Encephalomyelitis, Acute Disseminated	7.4%
204	Brain Diseases	7.4%
205	Dysautonomia	7.4%
206	Meningitis	7.4%
207	Movement Disorders	7.4%
208	Pachymeningitis	7.4%
209	Spinal Cord Diseases	7.4%
210	Vagus Nerve Disorder	7.4%
211	Glossopharyngeal Neuralgia	7.4%
212	Abducens Nerve Diseases	7.4%
213	Heavy Metal Poisoning, Nervous System	7.4%
214	Trochlear Nerve Diseases	7.4%
215	Ectodermal Dysplasia	7.4%
216	Aplasia Cutis Congenita	7.4%
217	Sickle Cell Trait	7.3%
218	Smith-Lemli-Opitz Syndrome	7.2%
219	Diabetic Neuropathies	7.2%
220	Diabetic Amyotrophy	7.2%
221	Diabetic Autonomic Neuropathy	7.2%
222	Galactosemias	7.2%
223	Urea Cycle Disorders, Inborn	7.2%
224	Tyrosinemias	7.2%
225	Neuralgia	7.1%
226	Neuropathic pain	7.1%
227	Mobius Syndrome	7.1%
228	Leukoencephalopathy, Progressive Multifocal	7%
229	Congenital Hypothyroidism	7%
230	Brain Diseases, Metabolic, Inborn	7%
231	Glycogen storage disease type II	7%
232	Facial Nerve Injuries	7%
233	Kearns-Sayre syndrome	6.9%
234	Bone Diseases	6.9%
235	Fasciitis	6.9%
236	Foot Deformities	6.9%
237	Arthropathy	6.9%
238	Neuromuscular Diseases	6.9%
239	Deformity	6.9%
240	Osteoarthropathy, Secondary Hypertrophic	6.8%
241	Fasciitis, Plantar	6.8%
242	Kallmann Syndrome	6.7%
243	Antley-Bixler Syndrome Phenotype	6.7%
244	Akathisia, Drug-Induced	6.7%
245	Pectus excavatum	6.7%
246	Sjogren-Larsson Syndrome	6.7%
247	Brain Injuries	6.6%
248	Amino Acid Metabolism, Inborn Errors	6.6%
249	Anterior Compartment Syndrome	6.6%
250	Carbohydrate Metabolism, Inborn Errors	6.6%
251	Metal Metabolism, Inborn Errors	6.6%
252	Progeria	6.6%
253	Lysosomal Storage Diseases	6.6%
254	Enthesopathy	6.6%
255	Cytochrome-c Oxidase Deficiency	6.6%
256	Peroxisomal Disorders	6.6%
257	Abdominal Compartment Syndrome	6.6%
258	Horner Syndrome	6.6%
259	Anencephaly	6.6%
260	Brain Neoplasms	6.6%
261	Multiple Sclerosis	6.6%
262	Spinal Cord Neoplasms	6.6%
263	Subdural Effusion	6.6%
264	Parkinsonian Disorders	6.6%
265	Nocturnal Myoclonus Syndrome	6.6%
266	Polycystic Kidney Diseases	6.6%
267	Neuritis, Autoimmune, Experimental	6.6%
268	Primary Ciliary Dyskinesia	6.5%
269	Cubital Tunnel Syndrome	6.5%
270	Hand-Arm Vibration Syndrome	6.4%
271	Central Nervous System Infection	6.4%
272	Optic Neuropathy	6.4%
273	Arthritis, Gouty	6.3%
274	Lupus Vasculitis, Central Nervous System	6.3%
275	Facial Nerve Diseases	6.2%
276	Craniocerebral Trauma	6.2%
277	Parasomnia	6.2%
278	Dyssomnias	6.2%
279	Platybasia	6.2%
280	Klippel-Feil Syndrome	6.2%
281	Synostosis	6.2%
282	Vestibulocochlear Nerve Diseases	6.1%
283	Decerebrate State	6.1%
284	Hemiparesis	6.1%
285	Meningism	6.1%
286	Paresis	6.1%
287	Seizures	6.1%
288	Sensation Disorders	6.1%
289	Central Nervous System Neoplasms	6.1%
290	Complex partial seizures	6.1%
291	Monoparesis	6.1%
292	Neurogenic Inflammation	6.1%
293	Gait Disorders, Neurologic	6.1%
294	Neuromuscular Manifestations	6.1%
295	Epilepsy, Post-Traumatic	6.1%
296	Sweating, Gustatory	6.1%
297	Auriculotemporal Syndrome	6.1%
298	Acrocephalosyndactylia	6.1%
299	Frontotemporal dementia	6.1%
300	Zellweger Syndrome	6.1%
301	Homocystinuria	6.1%
302	Leigh Disease	6.1%
303	Retinal Dysplasia	6%
304	Craniosynostosis	6%
305	Syndactyly	6%
306	Brachycephaly	6%
307	Aniridia	6%
308	Acute Chest Syndrome	6%
309	Microcephaly	5.9%
310	Macrocephaly	5.9%
311	Vasculitis, Central Nervous System	5.9%
312	Sciatic Neuropathy	5.9%
313	Ulnar Neuropathies	5.9%
314	Lesion of Sciatic Nerve	5.9%
315	Ulnar Neuritis	5.9%
316	Radial nerve compression	5.9%
317	Radial Tunnel Syndrome	5.9%
318	Peroneal Neuropathies	5.9%
319	Radial Neuropathy	5.9%
320	Median Neuropathy	5.9%
321	Sciatic Nerve Palsy	5.9%
322	Femoral Neuropathy	5.9%
323	Tibial Neuropathy	5.9%
324	Ulnar Nerve Palsy	5.9%
325	Radial nerve palsy	5.9%
326	Jaw Diseases	5.9%
327	Epidermolysis Bullosa	5.9%
328	Jet Lag Syndrome	5.9%
329	Brain Abscess	5.8%
330	Ophthalmoplegia	5.8%
331	External Ophthalmoplegia	5.8%
332	Basal Cell Nevus Syndrome	5.8%
333	Osteochondritis	5.8%
334	Cartilage Diseases	5.8%
335	Fetal Diseases	5.8%
336	Foot Diseases	5.8%
337	Rheumatism	5.8%
338	Chondromalacia	5.8%
339	Gaucher Disease	5.8%
340	Metatarsalgia	5.8%
341	Leukomalacia, Periventricular	5.8%
342	Cutis Laxa	5.7%
343	Retinitis Pigmentosa	5.7%
344	Central Cord Syndrome	5.7%
345	Pigmentary retinopathy	5.7%
346	Dupuytren Contracture	5.7%
347	Porokeratosis	5.7%
348	Keratoderma, Palmoplantar	5.7%
349	Chronic granulomatous disease	5.7%
350	Meningitis, Bacterial	5.7%
351	Meningitis, Fungal	5.7%
352	Chorea	5.6%
353	neurofibroma	5.6%
354	Limb Deformities, Congenital	5.6%
355	Craniofacial Abnormalities	5.6%
356	Meningomyelocele	5.5%
357	Spina Bifida	5.5%
358	Meige Syndrome	5.5%
359	Cerebral Ventriculitis	5.5%
360	Dementia, Vascular	5.5%
361	Brain Hemorrhage, Traumatic	5.5%
362	Carbamoyl-Phosphate Synthase I Deficiency Disease	5.4%
363	Pupil Disorders	5.4%
364	Neurobehavioral Manifestations	5.4%
365	Mucopolysaccharidosis III	5.4%
366	POEMS Syndrome	5.3%
367	Hyperphosphaturia	5.3%
368	Tay-Sachs Disease	5.3%
369	Porencephaly	5.3%
370	Cerebellar Neoplasms	5.3%
371	Uveomeningoencephalitic Syndrome	5.3%
372	Sturge-Weber Syndrome	5.2%
373	Vertigo	5.2%
374	Congenital nystagmus	5.2%
375	Alcohol-Induced Disorders, Nervous System	5.2%
376	Vocal Cord Paralysis	5.2%
377	Talipes	5.2%
378	Osteoarthritis, Spine	5.1%
379	Niemann-Pick Disease, Type C	5.1%
380	Porphyrias, Hepatic	5%
381	Thoracic Outlet Syndrome	5%
382	Amblyopia	5%
383	Peutz-Jeghers Syndrome	5%
384	Thrombasthenia	5%
385	Antithrombin III Deficiency	5%
386	Protein C Deficiency	5%
387	Afibrinogenemia	4.9%
388	Factor VII Deficiency	4.9%
389	Factor X Deficiency	4.9%
390	Factor XII Deficiency	4.9%
391	Hemophilia A	4.9%
392	Activated Protein C Resistance	4.9%
393	Factor II deficiency	4.9%
394	Factor VIII Deficiency	4.9%
395	Factor V deficiency	4.9%
396	Factor XI Deficiency	4.9%
397	Hypoprothrombinemias	4.9%
398	Brain Death	4.9%
399	Coma, Post-Head Injury	4.9%
400	Alkaptonuria	4.9%
401	Cerebrospinal Fluid Otorrhea	4.9%
402	Cerebrospinal Fluid Rhinorrhea	4.9%
403	Fanconi Anemia	4.9%
404	Glycogen Storage Disease	4.9%
405	Hypophosphatasia	4.9%
406	Propionic acidemia	4.9%
407	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
408	Cystinosis	4.9%
409	Gait Ataxia	4.9%
410	Posterior Leukoencephalopathy Syndrome	4.9%
411	Posterior reversible encephalopathy syndrome	4.9%
412	Carotid Artery Injuries	4.9%
413	Anemia, Diamond-Blackfan	4.9%
414	Polycystic Kidney, Autosomal Dominant	4.9%
415	Pseudoxanthoma Elasticum	4.8%
416	Jaw Abnormalities	4.8%
417	Poland Syndrome	4.8%
418	Pseudohypoparathyroidism	4.8%
419	Rheumatic Fever	4.8%
420	Gastroschisis	4.8%
421	Toxoplasmosis, Congenital	4.7%
422	Meningocele	4.7%
423	Encephalocele	4.7%
424	Hyperkeratosis, Epidermolytic	4.7%
425	Craniofacial Dysostosis	4.7%
426	Creutzfeldt-Jakob disease	4.7%
427	Basal Ganglia Cerebrovascular Disease	4.7%
428	Voice Disorders	4.7%
429	Voice Disturbance	4.7%
430	Tuberculosis, Meningeal	4.7%
431	Brain Injuries, Diffuse	4.7%
432	Traumatic Brain Injury	4.7%
433	Cerebellar Ataxia	4.7%
434	Supratentorial Neoplasms	4.7%
435	Torticollis	4.7%
436	Multiple Sclerosis, Chronic Progressive	4.7%
437	Multiple Sclerosis, Relapsing-Remitting	4.7%
438	Akinetic Mutism	4.6%
439	Anoxic Encephalopathy	4.6%
440	Arachnoiditis	4.6%
441	Basal Ganglia Diseases	4.6%
442	Brain Damage, Chronic	4.6%
443	Cerebellar Diseases	4.6%
444	Encephalitis	4.6%
445	Encephalomalacia	4.6%
446	Epilepsy	4.6%
447	Hydrocephalus	4.6%
448	Congenital Hydrocephalus	4.6%
449	Hypothalamic Diseases	4.6%
450	Aseptic Meningitis	4.6%
451	Syringomyelia	4.6%
452	Thalamic Diseases	4.6%
453	Intracranial Hypertension	4.6%
454	Aura	4.6%
455	Leukoencephalopathy	4.6%
456	Essential Tremor	4.6%
457	Neuroaxonal Dystrophies	4.6%
458	Familial Tremor	4.6%
459	Headache Disorders	4.6%
460	Intracranial Hypotension	4.6%
461	Brain Edema	4.6%
462	Brain Hypoxia	4.6%
463	Aqueductal Stenosis	4.6%
464	Pneumorrhachis	4.6%
465	Writer's Cramp	4.6%
466	Alcohol Withdrawal Seizures	4.6%
467	Polyradiculopathy	4.6%
468	Maxillofacial Abnormalities	4.6%
469	Meconium Aspiration Syndrome	4.5%
470	Multiple Endocrine Neoplasia	4.5%
471	Xeroderma Pigmentosum	4.5%
472	Dermatitis, Atopic	4.4%
473	Periarthritis	4.4%
474	Alice in Wonderland Syndrome	4.4%
475	Optic Nerve Glioma	4.4%
476	Akathisia	4.4%
477	Restlessness	4.4%
478	Psychomotor Agitation	4.4%
479	Myoclonic Epilepsy	4.3%
480	Epilepsy, Temporal Lobe	4.3%
481	Epilepsy, Rolandic	4.3%
482	Benign Rolandic Epilepsy	4.3%
483	Brain Concussion	4.2%
484	Rheumatoid Arthritis	4.2%
485	Juvenile arthritis	4.2%
486	Vascular Headaches	4.2%
487	Congenital clubfoot	4.2%
488	Vertical Talus	4.2%
489	Hypolipoproteinemias	4.2%
490	Papillon-Lefevre Disease	4.2%
491	Hyperlipidemia, Familial Combined	4.2%
492	Hypoxia-Ischemia, Brain	4.2%
493	Hyperlipoproteinemia Type III	4.2%
494	Tardive Dyskinesia	4.2%
495	Xeroderma	4.2%
496	Persistent Vegetative State	4.2%
497	Prognathism	4.2%
498	Toxoplasmosis, Cerebral	4.2%
499	Pituitary Adenoma	4.1%
500	Pituitary Neoplasms	4.1%
501	Dermal Sinus	4.1%
502	Spina Bifida Cystica	4.1%
503	Spina Bifida Occulta	4.1%
504	Lissencephaly	4.1%
505	Polymicrogyria	4.1%
506	Pachygyria	4.1%
507	Schizencephaly	4.1%
508	Periventricular Nodular Heterotopia	4.1%
509	Ankylosing spondylitis	4.1%
510	Glycogen Storage Disease Type I	4.1%
511	Glycogen Storage Disease Type V	4.1%
512	Reflex, Abnormal	4%
513	Hyporeflexia	4%
514	Hyperreflexia	4%
515	Abdominal Cramps	4%
516	Abnormalities, Drug-Induced	4%
517	Amniotic Band Syndrome	4%
518	Arthritis	4%
519	Asphyxia Neonatorum	4%
520	Bone Diseases, Developmental	4%
521	Bursitis	4%
522	Hyperostosis	4%
523	Infant, Premature, Diseases	4%
524	Joint Instability	4%
525	Osteitis	4%
526	Osteitis Deformans	4%
527	Osteochondrosis	4%
528	Situs Inversus	4%
529	Spinal Diseases	4%
530	Synovitis	4%
531	Joint laxity	4%
532	Polyarthritis	4%
533	Infantile Colic	4%
534	Frozen shoulder	4%
535	Patellofemoral Pain Syndrome	4%
536	Vertebral Artery Dissection	4%
537	Amnesia, Transient Global	4%
538	Gait Apraxia	4%
539	Behcet Syndrome	4%
540	Brain Diseases, Metabolic	3.9%
541	Cerebrovascular Disorders	3.9%
542	Optic Atrophy	3.9%
543	Optic Neuritis	3.9%
544	Papilledema	3.9%
545	Strabismus	3.9%
546	Tolosa-Hunt Syndrome	3.9%
547	Cerebrovascular Insufficiency	3.9%
548	Arsenic Poisoning	3.9%
549	Dementia	3.9%
550	Central Nervous System Fungal Infections	3.9%
551	Conus Medullaris Syndrome	3.9%
552	Spinal Cord Vascular Diseases	3.9%
553	Facial Injuries	3.9%
554	Facial Neuralgia	3.9%
555	Sleep Talking	3.9%
556	Manganese Poisoning	3.9%
557	Sleep Disorders, Intrinsic	3.9%
558	Orthostatic intolerance	3.9%
559	Amelia	3.8%
560	Anosmia	3.8%
561	Arachnodactyly	3.8%
562	Ataxia	3.8%
563	Athetosis	3.8%
564	Catalepsy	3.8%
565	Dystonia	3.8%
566	Ectromelia	3.8%
567	Hemimelia	3.8%
568	Hemiplegia	3.8%
569	Locked-In Syndrome	3.8%
570	Meningeal Neoplasms	3.8%
571	Muscle Hypertonia	3.8%
572	Muscle hypotonia	3.8%
573	Myoclonus	3.8%
574	Myotonia	3.8%
575	Paraplegia	3.8%
576	Phocomelia	3.8%
577	Pseudobulbar Palsy	3.8%
578	Quadriplegia	3.8%
579	Sirenomelia	3.8%
580	Spasm	3.8%
581	Spastic Paraplegia	3.8%
582	Status Epilepticus	3.8%
583	Taste Disorders	3.8%
584	Tremor	3.8%
585	Monoplegia	3.8%
586	Hypokinesia	3.8%
587	Polydactyly	3.8%
588	Paraparesis	3.8%
589	Brachydactyly	3.8%
590	Bradykinesia	3.8%
591	Waxy flexibility	3.8%
592	Action Tremor	3.8%
593	Resting Tremor	3.8%
594	Dysosmia	3.8%
595	Plagiocephaly	3.8%
596	Quadriparesis	3.8%
597	Osteoarthritis, Knee	3.8%
598	Lower Extremity Deformities, Congenital	3.8%
599	Mercury Poisoning, Nervous System	3.8%
600	Olfaction Disorders	3.8%
601	Myokymia	3.8%
602	Upper Extremity Deformities, Congenital	3.8%
603	Lead Poisoning, Nervous System	3.8%
604	Vestibular Neuronitis	3.8%
605	Somatosensory Disorders	3.8%
606	Hyperkinesia	3.8%
607	Intention tremor	3.8%
608	Juvenile Myoclonic Epilepsy	3.8%
609	Myoclonic Epilepsies, Progressive	3.8%
610	Gigantism	3.8%
611	Spinal Neoplasms	3.8%
612	Spondylitis	3.8%
613	Laryngomalacia	3.8%
614	Basal Ganglia Hemorrhage	3.7%
615	Diffuse Axonal Injury	3.7%
616	Brain Stem Neoplasms	3.7%
617	Lactose Intolerance	3.7%
618	Variegate Porphyria	3.7%
619	Acute intermittent porphyria	3.7%
620	Porphyria Cutanea Tarda	3.7%
621	Klinefelter Syndrome	3.7%
622	Meningitis, Cryptococcal	3.7%
623	Hyperhomocysteinemia	3.7%
624	Micrognathism	3.7%
625	Pierre Robin Syndrome	3.7%
626	Renal Aminoacidurias	3.7%
627	Fanconi Syndrome	3.7%
628	Meningitis, Listeria	3.7%
629	Pseudohypoaldosteronism	3.7%
630	Liddle Syndrome	3.7%
631	Meningitis, Haemophilus	3.7%
632	Meningitis, Pneumococcal	3.7%
633	Hyperlipoproteinemia Type IV	3.7%
634	Hyperlipoproteinemia Type V	3.7%
635	Neurofibrosarcoma	3.6%
636	Cleft Palate	3.6%
637	Arthritis, Psoriatic	3.6%
638	Acromegaly	3.5%
639	Subarachnoid Hemorrhage, Traumatic	3.5%
640	Carotid Artery, Internal, Dissection	3.5%
641	Acoustic Neuroma	3.5%
642	Familial Hypophosphatemic Rickets	3.5%
643	Hypoalphalipoproteinemias	3.5%
644	Bone Diseases, Endocrine	3.5%
645	Eye Abnormalities	3.5%
646	Myopathy	3.5%
647	Cardiovascular Abnormalities	3.5%
648	Hydrops Fetalis	3.5%
649	Subacute Sclerosing Panencephalitis	3.4%
650	Turner Syndrome	3.4%
651	Vision Disorders	3.4%
652	Metamorphopsia	3.4%
653	Visual Impairment	3.4%
654	Bone Diseases, Infectious	3.4%
655	Bone neoplasms	3.4%
656	Maxillary Diseases	3.4%
657	Osteopenia	3.4%
658	Skin Abnormalities	3.4%
659	Lymphatic Abnormalities	3.4%
660	Congenital Microtia	3.4%
661	Optic Neuropathy, Ischemic	3.4%
662	Anterior Ischemic Optic Neuropathy	3.4%
663	Central Nervous System Bacterial Infections	3.4%
664	Anemia, Neonatal	3.4%
665	Bone Resorption	3.4%
666	Hemarthrosis	3.4%
667	Persistent Fetal Circulation Syndrome	3.4%
668	Tietze's Syndrome	3.4%
669	Aseptic Necrosis of Bone	3.4%
670	Facial Hemiatrophy	3.3%
671	Melkersson-Rosenthal Syndrome	3.3%
672	Retrognathia	3.3%
673	Anisocoria	3.3%
674	Confusion	3.3%
675	Facial paralysis	3.3%
676	Lethargy	3.3%
677	Memory Disorders	3.3%
678	Perceptual Disorders	3.3%
679	Psychomotor Disorders	3.3%
680	Tonic Pupil	3.3%
681	Anhedonia	3.3%
682	Disorientation	3.3%
683	Congenital diaphragmatic hernia	3.3%
684	Facial Paresis	3.3%
685	Memory Loss	3.3%
686	Hemisensory Neglect	3.3%
687	Dysacusis	3.3%
688	Umbilical hernia	3.3%
689	Noonan Syndrome	3.3%
690	Sleep Bruxism	3.3%
691	Muscular Atrophy	3.3%
692	Respiratory Paralysis	3.3%
693	Multiple Endocrine Neoplasia Type 1	3.3%
694	Pituitary Apoplexy	3.3%
695	Putaminal Hemorrhage	3.3%
696	Cerebral Palsy	3.3%
697	Epilepsies, Partial	3.3%
698	Epilepsy, Generalized	3.3%
699	Pseudotumor Cerebri	3.3%
700	Hypertensive Encephalopathy	3.3%
701	Simple Partial Seizures	3.3%
702	Epilepsy, Reflex	3.3%
703	Postural Orthostatic Tachycardia Syndrome	3.3%
704	Headache Disorders, Primary	3.3%
705	Headache Disorders, Secondary	3.3%
706	Medication overuse headache	3.3%
707	Rheumatoid Nodule	3.3%
708	Tetany	3.3%
709	Nephroblastoma	3.3%
710	Auditory Perceptual Disorders	3.3%
711	Giant Cell Arteritis	3.3%
712	Temporal Arteritis	3.3%
713	Mandibulofacial Dysostosis	3.3%
714	Brain Contusion	3.3%
715	Renal tubular acidosis	3.3%
716	Brain Infarction	3.3%
717	Goldenhar Syndrome	3.2%
718	Choroid Plexus Papilloma	3.2%
719	Infarction, Middle Cerebral Artery	3.2%
720	Infarction, Anterior Cerebral Artery	3.2%
721	Infarction, Posterior Cerebral Artery	3.2%
722	Arthritis, Reactive	3.2%
723	Cystinuria	3%
724	Adenomatous Polyposis Coli	3%
725	Kernicterus	3%
726	Spondylarthropathies	3%
727	Urogenital Abnormalities	3%
728	Consciousness Disorders	2.9%
729	Mental Retardation	2.9%
730	Depressed Level of Consciousness	2.9%
731	Mental deficiency	2.9%
732	Intellectual Disability	2.9%
733	Bell Palsy	2.9%
734	Neonatal Abstinence Syndrome	2.9%
735	Catatonia	2.9%
736	Herpes Zoster Oticus	2.9%
737	Aphonia	2.9%
738	Dextrocardia	2.9%
739	Sleep Deprivation	2.9%
740	Dysphonia	2.9%
741	Alexia	2.9%
742	Dyslexia	2.9%
743	Felty Syndrome	2.9%
744	Bronchomalacia	2.9%
745	Tracheomalacia	2.9%
746	Fetal Growth Retardation	2.9%
747	Fetal Hypoxia	2.9%
748	Fetal Alcohol Spectrum Disorders	2.9%
749	Pituitary Diseases	2.8%
750	Syphilis, Congenital	2.8%
751	Cerebral Infarction	2.8%
752	Brain Stem Infarctions	2.8%
753	Discitis	2.8%
754	West Nile Fever	2.8%
755	Hematoma, Subdural	2.8%
756	Hematoma, Epidural, Cranial	2.8%
757	Carotid Artery Diseases	2.7%
758	Brain Ischemia	2.7%
759	Esotropia	2.7%
760	Exotropia	2.7%
761	Hypotension, Orthostatic	2.7%
762	Sleep Apnea Syndromes	2.7%
763	Cerebrovascular accident	2.7%
764	Kluver-Bucy Syndrome	2.7%
765	Vasospasm, Intracranial	2.7%
766	Spinal Cord Ischemia	2.7%
767	Intracranial Arterial Diseases	2.7%
768	Post-Exercise Hypotension	2.7%
769	Disorders of Excessive Somnolence	2.7%
770	Sleep Initiation and Maintenance Disorders	2.7%
771	Night Terrors	2.7%
772	Somnambulism	2.7%
773	Trigeminal Nerve Disorder	2.7%
774	Transient Insomnia	2.7%
775	Sleep Paralysis	2.7%
776	Chronic Insomnia	2.7%
777	REM Sleep Behavior Disorder	2.7%
778	Hypersomnia	2.7%
779	Dysgeusia	2.7%
780	Formication	2.7%
781	Hyperalgesia	2.7%
782	Hyperesthesia	2.7%
783	Hypesthesia	2.7%
784	Language Disorders	2.7%
785	Numbness	2.7%
786	Paresthesia	2.7%
787	Paraparesis, Spastic	2.7%
788	Trismus	2.7%
789	Epilepsia Partialis Continua	2.7%
790	Hypogeusia	2.7%
791	Meningeal Carcinomatosis	2.7%
792	Brown-Sequard Syndrome	2.7%
793	Lockjaw	2.7%
794	Allodynia	2.7%
795	Lead Poisoning, Nervous System, Childhood	2.7%
796	Lead Poisoning, Nervous System, Adult	2.7%
797	Ageusia	2.7%
798	Tuberculosis, Central Nervous System	2.7%
799	Moyamoya Disease	2.7%
800	Glycosuria, Renal	2.7%
801	Ainhum	2.6%
802	Bunion	2.6%
803	Dysostoses	2.6%
804	Prune Belly Syndrome	2.6%
805	Spinal Stenosis	2.6%
806	Spondylosis	2.6%
807	Twins, Conjoined	2.6%
808	Intervertebral Disc Degeneration	2.6%
809	Sacroiliitis	2.6%
810	Waardenburg Syndrome	2.6%
811	Post-Traumatic Headache	2.6%
812	Tension Headache	2.6%
813	Epilepsy, Complex Partial	2.6%
814	Migraine Disorders	2.6%
815	Abdominal Migraine	2.6%
816	Status Migrainosus	2.6%
817	Cervicogenic Headache	2.6%
818	Lateral Medullary Syndrome	2.6%
819	Rheumatoid Vasculitis	2.6%
820	Giant Cell Epulis	2.5%
821	Congenital Hyperinsulinism	2.5%
822	Chorioamnionitis	2.5%
823	Arthralgia	2.5%
824	Myotonia Congenita	2.5%
825	Polyarthralgia	2.5%
826	Tuberculosis, Spinal	2.4%
827	Eye Injuries	2.4%
828	Scimitar Syndrome	2.4%
829	Diplopia	2.4%
830	Scotoma	2.4%
831	Photophobia	2.4%
832	Hemifacial Spasm	2.4%
833	Amaurosis	2.4%
834	Blindness	2.4%
835	Reye Syndrome	2.4%
836	Neuroaspergillosis	2.4%
837	Intracranial Embolism and Thrombosis	2.3%
838	Hepatic Encephalopathy	2.3%
839	Agnosia	2.3%
840	Apraxias	2.3%
841	Hallucinations	2.3%
842	Hemianopsia	2.3%
843	Hyperacusis	2.3%
844	Tinnitus	2.3%
845	Visual Agnosia	2.3%
846	Anosognosia	2.3%
847	Wernicke-Korsakoff Syndrome	2.3%
848	Phonophobia	2.3%
849	Hearing Loss	2.3%
850	Hematoma, Subdural, Intracranial	2.3%
851	Hematoma, Subdural, Chronic	2.3%
852	Hematoma, Subdural, Acute	2.3%
853	Hoarseness	2.3%
854	Sarcopenia	2.3%
855	Denys-Drash Syndrome	2.3%
856	Alcohol Withdrawal Delirium	2.3%
857	Sicca Syndrome	2.3%
858	Sjogren's Syndrome	2.3%
859	Cluster Headache	2.3%
860	Migraine with Aura	2.3%
861	Familial Hemiplegic Migraine	2.3%
862	Chronic Paroxysmal Hemicrania	2.3%
863	SUNCT Syndrome	2.3%
864	Paroxysmal Hemicrania	2.3%
865	Anophthalmos	2.2%
866	Anus, Imperforate	2.2%
867	Arthritis, Infectious	2.2%
868	Microphthalmos	2.2%
869	Paralysis, Obstetric	2.2%
870	Retinopathy of Prematurity	2.2%
871	Myotonic Disorders	2.2%
872	Anorectal Malformations	2.2%
873	Empty Sella Syndrome	2.2%
874	Hyperpituitarism	2.2%
875	Hypopituitarism	2.2%
876	Hypophysitis	2.2%
877	Abnormalities, Radiation-Induced	2.2%
878	Bloom Syndrome	2.2%
879	Osteomyelitis	2.2%
880	Osteoporosis	2.2%
881	Periostitis	2.2%
882	Bone Demineralization, Pathologic	2.2%
883	Post-Traumatic Osteoporosis	2.2%
884	Arthritis, Experimental	2.2%
885	Eosinophilic Granuloma	2.2%
886	Alveolar Bone Loss	2.2%
887	Bronchopulmonary Dysplasia	2.2%
888	Femur Head Necrosis	2.2%
889	Osteolysis	2.2%
890	Cerebral Arterial Diseases	2.2%
891	Vertebrobasilar Insufficiency	2.2%
892	Anterior Spinal Artery Syndrome	2.2%
893	Basilar Artery Stenosis	2.2%
894	Vertebral Artery Stenosis	2.2%
895	Sleep Apnea, Obstructive	2.2%
896	Sleep Apnea, Central	2.2%
897	Intracranial Hemorrhage, Hypertensive	2.2%
898	Transient Cerebral Ischemia	2.2%
899	Narcolepsy	2.2%
900	Trigeminal Neuralgia	2.2%
901	Kleine-Levin Syndrome	2.2%
902	Agraphia	2.2%
903	Anomia	2.2%
904	Cluttering	2.2%
905	Language Development Disorders	2.2%
906	Speech Disorders	2.2%
907	Syncope	2.2%
908	Stupor	2.2%
909	Dysgraphia	2.2%
910	Presyncope	2.2%
911	Dyslalia	2.2%
912	Pseudorabies	2.1%
913	Palatal Neoplasms	2.1%
914	Amnesia	2.1%
915	Delirium	2.1%
916	Dissociative Amnesia	2.1%
917	Color blindness	2.1%
918	Global Amnesia	2.1%
919	Meningioma	2.1%
920	Neurosyphilis	2%
921	Chondrodysplasia Punctata	2%
922	Enchondromatosis	2%
923	Lordosis	2%
924	Osteosclerosis	2%
925	Spondylolysis	2%
926	kyphosis	2%
927	Kashin-Beck Disease	2%
928	Ophthalmia Neonatorum	2%
929	Blepharophimosis	1.9%
930	Hip Dislocation	1.9%
931	Laryngostenosis	1.9%
932	Mouth Abnormalities	1.9%
933	Respiratory Distress Syndrome, Newborn	1.9%
934	Shoulder Dislocation	1.9%
935	Hip Dysplasia	1.9%
936	Hyperprolactinemia	1.9%
937	Esophageal Atresia	1.9%
938	Intestinal Atresia	1.9%
939	Horseshoe Kidney	1.9%
940	Subclavian Steal Syndrome	1.9%
941	Pick Disease of the Brain	1.9%
942	Cataplexy	1.9%
943	Acrodermatitis	1.9%
944	Aphasia	1.9%
945	Articulation Disorders	1.9%
946	Echolalia	1.9%
947	Lymphangiectasis, Intestinal	1.9%
948	Stuttering	1.9%
949	Gianotti-Crosti Syndrome	1.9%
950	Dysphasia	1.9%
951	Eye Burns	1.9%
952	Malaria, Cerebral	1.9%
953	Joint Tuberculosis	1.9%
954	Tuberculosis, Osteoarticular	1.9%
955	Bone Tuberculosis	1.9%
956	Carotid Stenosis	1.9%
957	Intracranial Aneurysm	1.9%
958	Waterhouse-Friderichsen Syndrome	1.9%
959	Neurocysticercosis	1.9%
960	Amaurosis Fugax	1.9%
961	Blindness, Cortical	1.9%
962	Dyscalculia	1.9%
963	Intracranial Arteriosclerosis	1.9%
964	Cerebral Atherosclerosis	1.9%
965	Subarachnoid Hemorrhage	1.9%
966	Cerebral Arteriosclerosis	1.9%
967	Cerebral Hemorrhage	1.9%
968	Cerebral Thrombosis	1.9%
969	Intracranial Embolism	1.9%
970	Intracranial Thrombosis	1.9%
971	Deafness	1.9%
972	Hearing Loss, Sudden	1.9%
973	Gerstmann Syndrome	1.9%
974	Hearing Loss, Bilateral	1.9%
975	Hearing Loss, High-Frequency	1.9%
976	Hearing Loss, Mixed Conductive-Sensorineural	1.9%
977	Prosopagnosia	1.9%
978	Apraxia, Ideomotor	1.9%
979	Charles Bonnet Syndrome	1.9%
980	Hearing Loss, Unilateral	1.9%
981	Complete Hearing Loss	1.9%
982	Alien Hand Syndrome	1.9%
983	Deaf Mutism	1.9%
984	Wernicke Encephalopathy	1.8%
985	AIDS Dementia Complex	1.8%
986	Phantom pain	1.8%
987	Phantom Limb Pain	1.8%
988	Lyme Neuroborreliosis	1.8%
989	Dysarthria	1.8%
990	Choanal Atresia	1.7%
991	Tracheobronchomegaly	1.7%
992	Laryngocele	1.7%
993	Choledochal Cyst	1.7%
994	Hermaphroditism	1.7%
995	Disorders of Sex Development	1.7%
996	Cryptorchidism	1.7%
997	Hypospadias	1.7%
998	Corneal Scar	1.7%
999	Ectopia Cordis	1.6%
1000	Single umbilical artery	1.6%
1001	Rickets	1.6%
1002	Mutism	1.6%
1003	Selective Mutism	1.6%
1004	Melorheostosis	1.6%
1005	Nesidioblastosis	1.6%
1006	Osteopetrosis	1.6%
1007	Osteoporosis, Postmenopausal	1.6%
1008	Spondylolisthesis	1.6%
1009	Retrograde amnesia	1.6%
1010	Amnesia, Anterograde	1.6%
1011	Shoulder Pain	1.6%
1012	Carotid Artery Thrombosis	1.6%
1013	Cerebral Amyloid Angiopathy	1.6%
1014	Sinus Thrombosis, Intracranial	1.6%
1015	Alexia, Pure	1.5%
1016	Cavernous Sinus Thrombosis	1.5%
1017	Sagittal Sinus Thrombosis	1.5%
1018	Bladder Exstrophy	1.5%
1019	Epispadias	1.5%
1020	Multicystic Dysplastic Kidney	1.5%
1021	Corneal Perforation	1.4%
1022	Aortic coarctation	1.4%
1023	Cor Triatriatum	1.4%
1024	Coronary Vessel Anomalies	1.4%
1025	Dental Enamel Hypoplasia	1.4%
1026	Patent ductus arteriosus	1.4%
1027	Ebstein Anomaly	1.4%
1028	Heart Septal Defects	1.4%
1029	Hyaline Membrane Disease	1.4%
1030	Hypodontia	1.4%
1031	Macrostomia	1.4%
1032	Microstomia	1.4%
1033	Tetralogy of Fallot	1.4%
1034	Transposition of Great Vessels	1.4%
1035	Hypoplastic Left Heart Syndrome	1.4%
1036	May-Thurner Syndrome	1.4%
1037	Mastoiditis	1.4%
1038	Wolff-Parkinson-White Syndrome	1.4%
1039	Petrositis	1.4%
1040	Hyperandrogenism	1.3%
1041	Nelson Syndrome	1.3%
1042	Prolactinoma	1.3%
1043	Growth Hormone-Secreting Pituitary Adenoma	1.3%
1044	Long QT Syndrome	1.2%
1045	Tricuspid Atresia	1.2%
1046	Arrhythmogenic Right Ventricular Dysplasia	1.2%
1047	Gonadal Dysgenesis	1.2%
1048	Adrenogenital Syndrome	1.2%
1049	Ovotesticular Disorders of Sex Development	1.2%
1050	Osteomalacia	1.2%
1051	Aortopulmonary Septal Defect	1.2%
1052	Double Outlet Right Ventricle	1.2%
1053	Endocardial Cushion Defects	1.2%
1054	Myocardial bridging	1.2%
1055	Aorticopulmonary Septal Defect	1.2%
1056	Truncus Arteriosus, Persistent	1%
1057	Romano-Ward Syndrome	1%
1058	Nose Neoplasms	0.9%
1059	Radicular Cyst	0.9%
1060	Renal Osteodystrophy	0.9%
1061	Renal rickets	0.9%
1062	Arteriovenous fistula	0.8%

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