MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Tay-Sachs Disease

(UMLS:C0039373)

Definition:: An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased HEXOSAMINIDASE B but absence of hexosaminidase A) and is strongly associated with Ashkenazic Jewish ancestry.
UMLS ID:: C0039373
MeSH ID:: D013661

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.435.825.300.300.500

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.189.435.825.300.300.500|C16.320.565.398.641.803.350.300.850|C16.320.565.595.554.825.300.300.840

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.435.825.300.300.500|C18.452.584.687.803.350.300.850|C18.452.648.189.435.825.300.300.500|C18.452.648.398.641.803.350.300.850|C18.452.648.595.554.825.300.300.840

Synonym(s)

Tay-Sachs Disease

GANGLIOSIDOSIS GM2 TYPE 1

GM2 gangliosidosis

GM2 gangliosidosis, type 1

GM2 gangliosidosis, type I

GM>2< gangliosidosis, type 1

Hexosaminidase A deficiency

INFANTILE GANGLIOSIDE LIPIDOSIS

LIPIDOSIS, GANGLIOSIDE, INFANTILE

10.

Sachs

11.

Sachs-Tay

12.

Severe hexosaminidase A deficiency

13.

TAY SACH'S DISEASE

14.

TAY-SACHS DISEASE

15.

TSD

16.

Tay Sachs Disease

17.

Tay Sachs disease

18.

Tay-Sachs

19.

Tay-Sachs disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	miglustat	FAERS: 5		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Gaucher Disease	38.4%
2	Fabry Disease	36.4%
3	Galactosemias	34.8%
4	Urea Cycle Disorders, Inborn	34.8%
5	Tyrosinemias	34.8%
6	Leigh Disease	34%
7	Glycogen storage disease type II	32.9%
8	Adrenoleukodystrophy	31.9%
9	Hepatolenticular Degeneration	31.9%
10	Smith-Lemli-Opitz Syndrome	30.9%
11	Menkes Kinky Hair Syndrome	30.9%
12	Zellweger Syndrome	28.8%
13	Refsum Disease	28.8%
14	Amino Acid Metabolism, Inborn Errors	28.6%
15	Carbohydrate Metabolism, Inborn Errors	28.6%
16	Metal Metabolism, Inborn Errors	28.6%
17	Progeria	28.6%
18	Peroxisomal Disorders	28.6%
19	Homocystinuria	28%
20	Pseudohypoparathyroidism	25.8%
21	Wasting Syndrome	23.7%
22	Neuronal Ceroid-Lipofuscinoses	23.7%
23	Hyperphosphaturia	23.5%
24	Carbamoyl-Phosphate Synthase I Deficiency Disease	23.4%
25	Hypolipoproteinemias	23.3%
26	Brain Diseases, Metabolic, Inborn	23.3%
27	MELAS Syndrome	22.2%
28	Niemann-Pick Disease, Type C	21.8%
29	Cytochrome-c Oxidase Deficiency	21.4%
30	Hyperlipidemia, Familial Combined	20.8%
31	Hyperhomocysteinemia	20.4%
32	Lysosomal Storage Diseases	20.2%
33	Lactose Intolerance	20.1%
34	Sjogren-Larsson Syndrome	19.8%
35	Hyperlipoproteinemia Type IV	19.6%
36	Hyperlipoproteinemia Type V	19.6%
37	Werner Syndrome	19.6%
38	Hyperlipoproteinemia Type III	19.6%
39	Cystinosis	19.5%
40	Acid-Base Imbalance	19.4%
41	Calcium Metabolism Disorders	19.4%
42	Iron Metabolism Disorders	19.4%
43	Phosphorus Metabolism Disorders	19.4%
44	Water-Electrolyte Imbalance	19.4%
45	Mitochondrial Diseases	19.4%
46	Glucose Metabolism Disorders	19.4%
47	Lipodystrophy	18.7%
48	Hypercalcemia	17.9%
49	Hypocalcemia	17.9%
50	Milk-Alkali Syndrome	17.9%
51	Amyloid Neuropathies, Familial	17.9%
52	Osteopenia	17.8%
53	Albinism	17.7%
54	Ichthyosis, X-Linked	17.4%
55	Mitochondrial Encephalomyopathies	16.3%
56	Cockayne Syndrome	16.3%
57	Canavan Disease	16.2%
58	Alexander Disease	16.2%
59	Myelinolysis, Central Pontine	15.6%
60	Rickets	15.6%
61	Lipid Metabolism Disorders	15.5%
62	Mucopolysaccharidosis II	15.4%
63	Renal tubular acidosis	15.2%
64	Ataxia Telangiectasia	14.9%
65	Alkaptonuria	14.6%
66	Glycogen Storage Disease	14.6%
67	Hypophosphatasia	14.6%
68	Propionic acidemia	14.6%
69	Dihydropyrimidine Dehydrogenase Deficiency	14.6%
70	Reye Syndrome	14.5%
71	Hepatic Encephalopathy	14.5%
72	Mucopolysaccharidosis III	14.3%
73	Brain Diseases, Metabolic	14.2%
74	Familial Hypophosphatemic Rickets	13.4%
75	Glycosuria, Renal	13.3%
76	Kernicterus	13.1%
77	Familial Periodic Paralysis	13.1%
78	Nutrition Disorders	13%
79	Wernicke Encephalopathy	12.7%
80	Xanthomatosis	12.5%
81	Dyslipidemias	12.5%
82	Xanthoma	12.5%
83	Renal Aminoacidurias	12.4%
84	Fanconi Syndrome	12.4%
85	Pseudohypoaldosteronism	12.4%
86	Liddle Syndrome	12.4%
87	Hypoalphalipoproteinemias	12.4%
88	Antley-Bixler Syndrome Phenotype	12.3%
89	Porphyrias, Hepatic	12.3%
90	Cystic Fibrosis	12.2%
91	Fanconi Anemia	12.1%
92	Aicardi's syndrome	11.7%
93	Gout	11.7%
94	Lipomatosis	11.5%
95	CHARGE Syndrome	11.4%
96	Myasthenic Syndromes, Congenital	11.2%
97	Friedreich Ataxia	11%
98	Congenital Hyperinsulinism	11%
99	Neoplastic Syndromes, Hereditary	10.8%
100	Bloom Syndrome	10.7%
101	Xeroderma Pigmentosum	10.6%
102	Nail-Patella Syndrome	10.6%
103	Multiple Epiphyseal Dysplasia	10.6%
104	Osteochondrodysplasias	10.6%
105	Pelger-Huet Anomaly	10.6%
106	Optic Atrophy, Hereditary, Leber	10.3%
107	Muscular Dystrophy	10%
108	Dwarfism	9.9%
109	Acidosis	9.8%
110	Alkalosis	9.8%
111	Amyloidosis	9.8%
112	Calcinosis	9.8%
113	Hyperglycemia	9.8%
114	Hyperinsulinism	9.8%
115	Hyperkalemia	9.8%
116	Hypernatremia	9.8%
117	Hypoglycemia	9.8%
118	Hypokalemia	9.8%
119	Hyponatremia	9.8%
120	Hypophosphatemia	9.8%
121	Metabolic acidosis	9.8%
122	Iron Overload	9.8%
123	Osteogenesis Imperfecta	9.7%
124	HIV Wasting Syndrome	9.4%
125	Marfan Syndrome	9.3%
126	Muscular Dystrophy, Duchenne	9.2%
127	Diabetes Mellitus	9.1%
128	Kartagener Syndrome	9.1%
129	Anemia, Sickle Cell	9.1%
130	Thalassemia	9.1%
131	Autoimmune Lymphoproliferative Syndrome	9.1%
132	Dehydration	9%
133	Water Intoxication	9%
134	Achlorhydria	9%
135	Osteoporosis	9%
136	Bone Demineralization, Pathologic	9%
137	Post-Traumatic Osteoporosis	9%
138	Angioedemas, Hereditary	9%
139	Celiac Disease	8.9%
140	Sprue, Tropical	8.9%
141	Steatorrhea	8.9%
142	Sprue	8.9%
143	Mitochondrial Myopathies	8.8%
144	Smith-Magenis syndrome	8.6%
145	Prader-Willi Syndrome	8.5%
146	Alstrom Syndrome	8.5%
147	Tuberous Sclerosis	8.3%
148	Glycosuria	8.2%
149	Beckwith-Wiedemann Syndrome	8.2%
150	Wolf-Hirschhorn Syndrome	8.2%
151	Kallmann Syndrome	8.1%
152	Myotonic Dystrophy	8.1%
153	Osteomalacia	8.1%
154	Wiskott-Aldrich Syndrome	7.9%
155	Holoprosencephaly	7.9%
156	Cri-du-Chat Syndrome	7.8%
157	Down Syndrome	7.8%
158	Trisomy 21	7.8%
159	HIV-Associated Lipodystrophy Syndrome	7.8%
160	Deformity	7.8%
161	Glycogen Storage Disease Type I	7.8%
162	Glycogen Storage Disease Type V	7.8%
163	Necrobiosis Lipoidica Diabeticorum	7.6%
164	Dystonia Musculorum Deformans	7.5%
165	Fragile X Syndrome	7.3%
166	Huntington Disease	7.3%
167	Fetal Diseases	7.1%
168	Ectodermal Dysplasia	7.1%
169	Aplasia Cutis Congenita	7.1%
170	Rubinstein-Taybi Syndrome	7%
171	Kearns-Sayre syndrome	6.9%
172	Hypokalemic periodic paralysis	6.9%
173	Renal Osteodystrophy	6.6%
174	Renal rickets	6.6%
175	Cystinuria	6.6%
176	Diabetic Ketoacidosis	6.5%
177	Child Nutrition Disorders	6.5%
178	Hypervitaminosis A	6.5%
179	Infant Nutrition Disorders	6.5%
180	Malnutrition	6.5%
181	Amyotrophic Lateral Sclerosis	6.5%
182	Williams Syndrome	6.3%
183	Variegate Porphyria	6.3%
184	Acute intermittent porphyria	6.3%
185	Porphyria Cutanea Tarda	6.3%
186	Arthritis, Gouty	6.1%
187	Dandy-Walker Syndrome	6.1%
188	Polycystic Kidney Diseases	6%
189	Adiposis Dolorosa	5.9%
190	Familial Mediterranean Fever	5.8%
191	Retinal Dysplasia	5.7%
192	Nesidioblastosis	5.7%
193	Aniridia	5.7%
194	Epidermolysis Bullosa	5.7%
195	Meconium Aspiration Syndrome	5.7%
196	Marchiafava-Bignami Disease	5.6%
197	Lafora Disease	5.5%
198	Unverricht-Lundborg Syndrome	5.5%
199	Meningoencephalitis	5.5%
200	Primary Ciliary Dyskinesia	5.5%
201	Myotonia Congenita	5.3%
202	Encephalomyelitis	5.3%
203	Rett Syndrome	5.2%
204	Duane Retraction Syndrome	5.1%
205	Acidosis, Lactic	5.1%
206	Calciphylaxis	5.1%
207	Hemosiderosis	5.1%
208	Ketosis	5.1%
209	Ketonuria	5.1%
210	Ketoacidosis	5.1%
211	Ketonemia	5.1%
212	Vascular calcification	5.1%
213	Leukomalacia, Periventricular	5%
214	Mobius Syndrome	5%
215	Welander Distal Myopathy	5%
216	Brain Abscess	5%
217	Pseudoxanthoma Elasticum	5%
218	Pneumocephalus	5%
219	Subdural Effusion	5%
220	Cutis Laxa	4.9%
221	Retinitis Pigmentosa	4.9%
222	Pigmentary retinopathy	4.9%
223	Porokeratosis	4.9%
224	Keratoderma, Palmoplantar	4.9%
225	Chronic granulomatous disease	4.9%
226	Tetany	4.8%
227	Multiple System Atrophy	4.8%
228	Cerebral Amyloid Angiopathy	4.7%
229	Dementia, Vascular	4.7%
230	Sickle Cell Trait	4.6%
231	Acidosis, Respiratory	4.6%
232	Alkalosis, Respiratory	4.6%
233	Insulin Resistance	4.6%
234	Osteoporosis, Postmenopausal	4.6%
235	Peutz-Jeghers Syndrome	4.5%
236	Thrombasthenia	4.5%
237	Antithrombin III Deficiency	4.5%
238	Protein C Deficiency	4.5%
239	Afibrinogenemia	4.5%
240	Factor VII Deficiency	4.5%
241	Factor X Deficiency	4.5%
242	Factor XII Deficiency	4.5%
243	Hemophilia A	4.5%
244	Activated Protein C Resistance	4.5%
245	Factor II deficiency	4.5%
246	Factor VIII Deficiency	4.5%
247	Factor V deficiency	4.5%
248	Factor XI Deficiency	4.5%
249	Hypoprothrombinemias	4.5%
250	Xeroderma	4.5%
251	Anemia, Diamond-Blackfan	4.5%
252	Akinetic Mutism	4.5%
253	Anoxic Encephalopathy	4.5%
254	Basal Ganglia Diseases	4.5%
255	Brain Damage, Chronic	4.5%
256	Cerebellar Diseases	4.5%
257	Encephalitis	4.5%
258	Encephalomalacia	4.5%
259	Epilepsy	4.5%
260	Hydrocephalus	4.5%
261	Congenital Hydrocephalus	4.5%
262	Hypothalamic Diseases	4.5%
263	Thalamic Diseases	4.5%
264	Intracranial Hypertension	4.5%
265	Aura	4.5%
266	Leukoencephalopathy	4.5%
267	Neuroaxonal Dystrophies	4.5%
268	Headache Disorders	4.5%
269	Intracranial Hypotension	4.5%
270	Brain Edema	4.5%
271	Brain Hypoxia	4.5%
272	Aqueductal Stenosis	4.5%
273	Basal Cell Nevus Syndrome	4.4%
274	Ocular Motility Disorders	4.4%
275	Cyclophoria	4.4%
276	Gestational Diabetes	4.3%
277	Latent Autoimmune Diabetes in Adults	4.3%
278	Brain Injuries	4.3%
279	Multiple Endocrine Neoplasia	4.3%
280	Brain Neoplasms	4.3%
281	Diabetes Mellitus, Experimental	4.3%
282	Congenital Hypothyroidism	4.3%
283	Nephrocalcinosis	4.3%
284	Dermatitis, Atopic	4.2%
285	Cerebrovascular Disorders	4.1%
286	Cerebrovascular Insufficiency	4.1%
287	Dementia	4.1%
288	Lewy Body Disease	4.1%
289	Acute Chest Syndrome	4.1%
290	Behcet Syndrome	4%
291	Primary amyloidosis	3.9%
292	Abdominal Cramps	3.9%
293	Abnormalities, Drug-Induced	3.9%
294	Amniotic Band Syndrome	3.9%
295	Asphyxia Neonatorum	3.9%
296	Infant, Premature, Diseases	3.9%
297	Situs Inversus	3.9%
298	Infantile Colic	3.9%
299	Meningitis	3.8%
300	Movement Disorders	3.8%
301	Pachymeningitis	3.8%
302	Spinal Cord Diseases	3.8%
303	Brain Death	3.8%
304	Parkinsonian Disorders	3.8%
305	Basal Ganglia Cerebrovascular Disease	3.8%
306	Epilepsy, Post-Traumatic	3.8%
307	Amblyopia	3.7%
308	Epidural Abscess	3.7%
309	Charcot-Marie-Tooth Disease	3.7%
310	Toxoplasmosis, Congenital	3.6%
311	Eye Abnormalities	3.6%
312	Cardiovascular Abnormalities	3.6%
313	Central Nervous System Infection	3.6%
314	Skin Abnormalities	3.5%
315	Lymphatic Abnormalities	3.5%
316	Congenital Microtia	3.5%
317	Anemia, Neonatal	3.5%
318	Persistent Fetal Circulation Syndrome	3.5%
319	Congenital diaphragmatic hernia	3.5%
320	Umbilical hernia	3.5%
321	Congenital nystagmus	3.5%
322	Stiff-Person Syndrome	3.5%
323	Myelitis	3.5%
324	Nephroblastoma	3.5%
325	Hypercholesterolemia	3.5%
326	Hyperlipoproteinemias	3.5%
327	Hypertriglyceridemia	3.5%
328	Subacute Combined Degeneration	3.5%
329	Progressive supranuclear palsy	3.5%
330	CREST Syndrome	3.4%
331	Amnesia, Transient Global	3.3%
332	Urogenital Abnormalities	3.3%
333	Dural Arteriovenous Fistula	3.3%
334	Adenomatous Polyposis Coli	3.3%
335	Neonatal Abstinence Syndrome	3.3%
336	Deficiency Diseases	3.3%
337	Starvation	3.3%
338	Refeeding Syndrome	3.3%
339	Fetal Growth Retardation	3.2%
340	Frontotemporal dementia	3.2%
341	Fetal Hypoxia	3.2%
342	Fetal Alcohol Spectrum Disorders	3.2%
343	Syphilis, Congenital	3.2%
344	Posterior Leukoencephalopathy Syndrome	3.1%
345	Posterior reversible encephalopathy syndrome	3.1%
346	Classical Lissencephalies and Subcortical Band Heterotopias	3.1%
347	Polycystic Kidney, Autosomal Dominant	3.1%
348	Hyperkeratosis, Epidermolytic	3%
349	Anencephaly	3%
350	Central Nervous System Cysts	3%
351	Tay-Sachs Disease	3%
352	Chorioamnionitis	3%
353	Neuroleptic Malignant Syndrome	3%
354	Hydranencephaly	3%
355	Neural Tube Defects	3%
356	Tethered Cord Syndrome	3%
357	Iniencephaly	3%
358	Craniorachischisis	3%
359	Exencephaly	3%
360	Septo-Optic Dysplasia	3%
361	Cortical Dysplasia	3%
362	Malformations of Cortical Development	3%
363	Meige Syndrome	3%
364	Cerebral Ventriculitis	3%
365	Leukoencephalopathy, Progressive Multifocal	2.9%
366	Prion Diseases	2.9%
367	Vascular Headaches	2.9%
368	Hypoxia-Ischemia, Brain	2.9%
369	Parkinson Disease	2.9%
370	Limbic Encephalitis	2.8%
371	Abnormalities, Radiation-Induced	2.8%
372	Cerebellar Neoplasms	2.8%
373	Lupus Vasculitis, Central Nervous System	2.8%
374	Spinal Cord Injuries	2.7%
375	Creutzfeldt-Jakob disease	2.7%
376	Asterixis	2.7%
377	Ballismus	2.7%
378	Spinal Muscular Atrophy	2.7%
379	Progressive Muscular Atrophy	2.7%
380	Ophthalmia Neonatorum	2.6%
381	Cranial nerve diseases	2.6%
382	Demyelinating Diseases	2.6%
383	Demyelination	2.6%
384	Neuromuscular Diseases	2.6%
385	Chronobiology Disorders	2.6%
386	Vasculitis, Central Nervous System	2.6%
387	Restless Legs Syndrome	2.6%
388	Chronic Fatigue Syndrome	2.5%
389	Obesity	2.5%
390	Papillon-Lefevre Disease	2.5%
391	Poliomyelitis	2.5%
392	Presenile dementia	2.4%
393	Senile dementia	2.4%
394	Meningitis, Bacterial	2.4%
395	Meningitis, Fungal	2.4%
396	Ophthalmoplegic Migraine	2.4%
397	Striatonigral Degeneration	2.4%
398	Trauma, Nervous System	2.4%
399	Miller Fisher Syndrome	2.4%
400	Nervous System Neoplasms	2.4%
401	Neurologic Manifestations	2.4%
402	Neurotoxicity Syndromes	2.4%
403	Toxoplasmosis, Cerebral	2.4%
404	Motor Neuron Disease	2.3%
405	Akathisia, Drug-Induced	2.3%
406	Myelitis, Transverse	2.3%
407	Maxillofacial Abnormalities	2.3%
408	Dextrocardia	2.3%
409	Cerebral Palsy	2.3%
410	Epilepsies, Partial	2.3%
411	Epilepsy, Generalized	2.3%
412	Pseudotumor Cerebri	2.3%
413	Hypertensive Encephalopathy	2.3%
414	Simple Partial Seizures	2.3%
415	Epilepsy, Reflex	2.3%
416	Headache Disorders, Primary	2.3%
417	Headache Disorders, Secondary	2.3%
418	Medication overuse headache	2.3%
419	Paraneoplastic Cerebellar Degeneration	2.3%
420	Hydrops Fetalis	2.3%
421	Opsoclonus-Myoclonus Syndrome	2.2%
422	Polyradiculoneuropathy	2.2%
423	Polyradiculoneuritis	2.2%
424	Shy-Drager Syndrome	2.2%
425	Brain Hemorrhage, Traumatic	2.2%
426	Leukoencephalitis, Acute Hemorrhagic	2.2%
427	Sleep Wake Disorders	2.2%
428	Multiple Endocrine Neoplasia Type 1	2.2%
429	Brain Injuries, Diffuse	2.2%
430	Traumatic Brain Injury	2.2%
431	Cerebellar Ataxia	2.2%
432	Supratentorial Neoplasms	2.2%
433	Spinal Cord Neoplasms	2.1%
434	Myoclonic Epilepsy	2.1%
435	Epilepsy, Temporal Lobe	2.1%
436	Epilepsy, Rolandic	2.1%
437	Benign Rolandic Epilepsy	2.1%
438	Pituitary Diseases	2.1%
439	Carotid Artery Diseases	2.1%
440	Brain Ischemia	2.1%
441	Cerebrovascular accident	2.1%
442	Kluver-Bucy Syndrome	2.1%
443	Vasospasm, Intracranial	2.1%
444	Intracranial Arterial Diseases	2.1%
445	Persistent Vegetative State	2%
446	Scimitar Syndrome	2%
447	Carotid Artery Injuries	2%
448	Basal Ganglia Hemorrhage	2%
449	Dyskinesia, Drug-Induced	2%
450	Prune Belly Syndrome	1.9%
451	Twins, Conjoined	1.9%
452	Waardenburg Syndrome	1.9%
453	Turner Syndrome	1.9%
454	Arachnoiditis	1.9%
455	Aseptic Meningitis	1.9%
456	Syringomyelia	1.9%
457	Essential Tremor	1.9%
458	Familial Tremor	1.9%
459	Pneumorrhachis	1.9%
460	Writer's Cramp	1.9%
461	Intracranial Embolism and Thrombosis	1.9%
462	Encephalomyelitis, Acute Disseminated	1.9%
463	MPTP Poisoning	1.9%
464	Pituitary Adenoma	1.8%
465	Pituitary Neoplasms	1.8%
466	Pituitary Apoplexy	1.8%
467	Brain Infarction	1.8%
468	Anophthalmos	1.8%
469	Anus, Imperforate	1.8%
470	Microphthalmos	1.8%
471	Paralysis, Obstetric	1.8%
472	Retinopathy of Prematurity	1.8%
473	Limb Deformities, Congenital	1.8%
474	Craniofacial Abnormalities	1.8%
475	Anorectal Malformations	1.8%
476	Bronchopulmonary Dysplasia	1.8%
477	Central Nervous System Fungal Infections	1.8%
478	Conus Medullaris Syndrome	1.8%
479	Spinal Cord Vascular Diseases	1.8%
480	POEMS Syndrome	1.8%
481	Autonomic Dysreflexia	1.8%
482	Complex Regional Pain Syndromes	1.8%
483	Auditory Perceptual Disorders	1.7%
484	Lambert-Eaton Myasthenic Syndrome	1.7%
485	Denys-Drash Syndrome	1.7%
486	Kwashiorkor	1.7%
487	Magnesium Deficiency	1.7%
488	Potassium Deficiency	1.7%
489	Protein Deficiency	1.7%
490	Avitaminosis	1.7%
491	Klinefelter Syndrome	1.7%
492	Blepharophimosis	1.7%
493	Laryngostenosis	1.7%
494	Mouth Abnormalities	1.7%
495	Respiratory Distress Syndrome, Newborn	1.7%
496	Esophageal Atresia	1.6%
497	Intestinal Atresia	1.6%
498	Horseshoe Kidney	1.6%
499	Pectus excavatum	1.6%
500	Klippel-Feil Syndrome	1.6%
501	Gastroschisis	1.6%
502	Synostosis	1.6%
503	Acrodermatitis	1.6%
504	Lymphangiectasis, Intestinal	1.6%
505	Gianotti-Crosti Syndrome	1.6%
506	AIDS Dementia Complex	1.6%
507	Central Nervous System Bacterial Infections	1.6%
508	Peripheral Nerve Injuries	1.6%
509	Myasthenia Gravis	1.6%
510	Arthrogryposis	1.5%
511	Choanal Atresia	1.5%
512	Tracheobronchomegaly	1.5%
513	Laryngocele	1.5%
514	Choledochal Cyst	1.5%
515	Hermaphroditism	1.5%
516	Disorders of Sex Development	1.5%
517	Cryptorchidism	1.5%
518	Hypospadias	1.5%
519	Sleep Disorders, Circadian Rhythm	1.5%
520	Guillain-Barre Syndrome	1.5%
521	Meningomyelocele	1.5%
522	Spina Bifida	1.5%
523	Botulism	1.5%
524	Craniosynostosis	1.4%
525	Syndactyly	1.4%
526	Brachycephaly	1.4%
527	Microcephaly	1.4%
528	Macrocephaly	1.4%
529	Laryngomalacia	1.4%
530	Pectus carinatum	1.4%
531	Bladder Exstrophy	1.4%
532	Epispadias	1.4%
533	Tuberculosis, Meningeal	1.4%
534	Multicystic Dysplastic Kidney	1.4%
535	Obesity, Abdominal	1.4%
536	Meningocele	1.4%
537	Encephalocele	1.4%
538	Noonan Syndrome	1.4%
539	Scrapie	1.4%
540	Central Cord Syndrome	1.4%
541	Chorea	1.4%
542	Neuromyelitis Optica	1.3%
543	Vertebral Artery Dissection	1.3%
544	Pediatric Obesity	1.3%
545	Moyamoya Disease	1.3%
546	Dysautonomia	1.3%
547	Vagus Nerve Disorder	1.3%
548	Glossopharyngeal Neuralgia	1.3%
549	Abducens Nerve Diseases	1.3%
550	Heavy Metal Poisoning, Nervous System	1.3%
551	Neuromuscular Junction Diseases	1.3%
552	Tauopathies	1.3%
553	Trochlear Nerve Diseases	1.3%
554	Peripheral Nervous System Diseases	1.3%
555	Olfactory Nerve Injuries	1.2%
556	Horner Syndrome	1.2%
557	Myopathy	1.2%
558	Optic Neuropathy	1.2%
559	Facial Nerve Diseases	1.2%
560	Craniocerebral Trauma	1.2%
561	Parasomnia	1.2%
562	Dyssomnias	1.2%
563	Progressive bulbar palsy	1.2%
564	Bulbar palsy	1.2%
565	Vestibulocochlear Nerve Diseases	1.2%
566	Decerebrate State	1.2%
567	Hemiparesis	1.2%
568	Meningism	1.2%
569	Paresis	1.2%
570	Seizures	1.2%
571	Sensation Disorders	1.2%
572	Central Nervous System Neoplasms	1.2%
573	Complex partial seizures	1.2%
574	Monoparesis	1.2%
575	Neurogenic Inflammation	1.2%
576	Gait Disorders, Neurologic	1.2%
577	Neuromuscular Manifestations	1.2%
578	Post-Traumatic Headache	1.2%
579	Tension Headache	1.2%
580	Epilepsy, Complex Partial	1.2%
581	Migraine Disorders	1.2%
582	Abdominal Migraine	1.2%
583	Status Migrainosus	1.2%
584	Cervicogenic Headache	1.2%
585	Sweating, Gustatory	1.2%
586	Auriculotemporal Syndrome	1.2%
587	Facial Nerve Injuries	1.2%
588	Jet Lag Syndrome	1.2%
589	Giant Cell Arteritis	1.1%
590	Temporal Arteritis	1.1%
591	Meningitis, Cryptococcal	1.1%
592	Meningitis, Listeria	1.1%
593	Meningitis, Haemophilus	1.1%
594	Meningitis, Pneumococcal	1.1%
595	Acrocephalosyndactylia	1.1%
596	Juvenile Myoclonic Epilepsy	1.1%
597	Myoclonic Epilepsies, Progressive	1.1%
598	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.1%
599	Brain Concussion	1.1%
600	Diffuse Axonal Injury	1.1%
601	Brain Stem Neoplasms	1.1%
602	Pupil Disorders	1.1%
603	Neurobehavioral Manifestations	1.1%
604	Torticollis	1.1%
605	Myasthenia Gravis, Autoimmune, Experimental	1.1%
606	Paraneoplastic Encephalomyelitis	1.1%
607	Causalgia	1.1%
608	Uveomeningoencephalitic Syndrome	1.1%
609	Multiple Sclerosis	1.1%
610	Empty Sella Syndrome	1.1%
611	Hyperpituitarism	1.1%
612	Hypopituitarism	1.1%
613	Hypophysitis	1.1%
614	Sturge-Weber Syndrome	1.1%
615	Vertigo	1.1%
616	Alcohol-Induced Disorders, Nervous System	1.1%
617	Porencephaly	1.1%
618	Cerebral Arterial Diseases	1.1%
619	Vertebrobasilar Insufficiency	1.1%
620	Basilar Artery Stenosis	1.1%
621	Vertebral Artery Stenosis	1.1%
622	Intracranial Hemorrhage, Hypertensive	1.1%
623	Transient Cerebral Ischemia	1.1%
624	Putaminal Hemorrhage	1.1%
625	Jaw Abnormalities	1%
626	Brain Contusion	1%
627	Subacute Sclerosing Panencephalitis	1%
628	Cleft Palate	1%
629	Voice Disorders	1%
630	Voice Disturbance	1%
631	Ophthalmoplegia	1%
632	External Ophthalmoplegia	1%
633	Subarachnoid Hemorrhage, Traumatic	1%
634	Carotid Artery, Internal, Dissection	1%
635	Carotid Stenosis	1%
636	Intracranial Aneurysm	1%
637	Intracranial Arteriosclerosis	1%
638	Cerebral Atherosclerosis	1%
639	Subarachnoid Hemorrhage	1%
640	Cerebral Arteriosclerosis	1%
641	Cerebral Hemorrhage	1%
642	Cerebral Thrombosis	1%
643	Intracranial Embolism	1%
644	Intracranial Thrombosis	1%
645	Cerebral Infarction	1%
646	Brain Stem Infarctions	1%
647	Vocal Cord Paralysis	0.9%
648	Reflex, Abnormal	0.9%
649	Hyporeflexia	0.9%
650	Hyperreflexia	0.9%
651	Amelia	0.9%
652	Arachnodactyly	0.9%
653	Ectopia Cordis	0.9%
654	Ectromelia	0.9%
655	Hemimelia	0.9%
656	Phocomelia	0.9%
657	Sirenomelia	0.9%
658	Polydactyly	0.9%
659	Brachydactyly	0.9%
660	Plagiocephaly	0.9%
661	Lower Extremity Deformities, Congenital	0.9%
662	Upper Extremity Deformities, Congenital	0.9%
663	Single umbilical artery	0.9%
664	Carotid Artery Thrombosis	0.9%
665	Ascorbic Acid Deficiency	0.9%
666	Vitamin A Deficiency	0.9%
667	Vitamin D Deficiency	0.9%
668	Vitamin E Deficiency	0.9%
669	Marasmus	0.9%
670	Spinal Cord Ischemia	0.9%
671	Tuberculosis, Central Nervous System	0.9%
672	Reflex Sympathetic Dystrophy	0.9%
673	Nocturnal Myoclonus Syndrome	0.9%
674	Infarction, Middle Cerebral Artery	0.9%
675	Infarction, Anterior Cerebral Artery	0.9%
676	Infarction, Posterior Cerebral Artery	0.9%
677	Alcohol Withdrawal Seizures	0.9%
678	Alice in Wonderland Syndrome	0.9%
679	Aortic coarctation	0.8%
680	Cor Triatriatum	0.8%
681	Coronary Vessel Anomalies	0.8%
682	Dental Enamel Hypoplasia	0.8%
683	Patent ductus arteriosus	0.8%
684	Ebstein Anomaly	0.8%
685	Heart Septal Defects	0.8%
686	Hyaline Membrane Disease	0.8%
687	Hypodontia	0.8%
688	Macrostomia	0.8%
689	Microstomia	0.8%
690	Tetralogy of Fallot	0.8%
691	Transposition of Great Vessels	0.8%
692	Hypoplastic Left Heart Syndrome	0.8%
693	May-Thurner Syndrome	0.8%
694	Craniofacial Dysostosis	0.8%
695	Wolff-Parkinson-White Syndrome	0.8%
696	Neuroaspergillosis	0.8%
697	Acrodynia	0.8%
698	Long QT Syndrome	0.8%
699	Platybasia	0.8%
700	Tricuspid Atresia	0.8%
701	Arrhythmogenic Right Ventricular Dysplasia	0.8%
702	Gonadal Dysgenesis	0.8%
703	Bronchomalacia	0.8%
704	Adrenogenital Syndrome	0.8%
705	Tracheomalacia	0.8%
706	Ovotesticular Disorders of Sex Development	0.8%
707	Dermal Sinus	0.8%
708	Spina Bifida Cystica	0.8%
709	Spina Bifida Occulta	0.8%
710	Lissencephaly	0.8%
711	Polymicrogyria	0.8%
712	Pachygyria	0.8%
713	Schizencephaly	0.8%
714	Periventricular Nodular Heterotopia	0.8%
715	Pseudorabies	0.8%
716	Poland Syndrome	0.8%
717	Vitamin K Deficiency	0.8%
718	Neurosyphilis	0.8%
719	Cerebrospinal Fluid Otorrhea	0.7%
720	Cerebrospinal Fluid Rhinorrhea	0.7%
721	Neuritis, Autoimmune, Experimental	0.7%
722	Gait Ataxia	0.7%
723	Acoustic Neuroma	0.7%
724	Lyme Neuroborreliosis	0.7%
725	Akathisia	0.7%
726	Restlessness	0.7%
727	Psychomotor Agitation	0.7%
728	Tardive Dyskinesia	0.7%
729	Neuritis	0.6%
730	Polyneuritis	0.6%
731	Radiculitis	0.6%
732	Polyneuropathy	0.6%
733	Mononeuritis	0.6%
734	Mononeuropathies	0.6%
735	Brachial Plexus Neuropathies	0.6%
736	Radiculopathy	0.6%
737	Mononeuropathy Multiplex	0.6%
738	Nerve Root Compression	0.6%
739	Hematoma, Subdural	0.6%
740	Hematoma, Epidural, Cranial	0.6%
741	Hyperandrogenism	0.6%
742	Cluster Headache	0.6%
743	Migraine with Aura	0.6%
744	Familial Hemiplegic Migraine	0.6%
745	Chronic Paroxysmal Hemicrania	0.6%
746	SUNCT Syndrome	0.6%
747	Paroxysmal Hemicrania	0.6%
748	Coma, Post-Head Injury	0.6%
749	Optic Nerve Glioma	0.6%
750	Brachial Plexus Neuritis	0.6%
751	Neuralgic Amyotrophy	0.6%
752	Myositis	0.6%
753	Optic Atrophy	0.6%
754	Optic Neuritis	0.6%
755	Papilledema	0.6%
756	Strabismus	0.6%
757	Tolosa-Hunt Syndrome	0.6%
758	Isaacs syndrome	0.6%
759	Arsenic Poisoning	0.6%
760	Myotonic Disorders	0.6%
761	Choroid Plexus Papilloma	0.6%
762	Diabetic Neuropathies	0.6%
763	Facial Injuries	0.6%
764	Facial Neuralgia	0.6%
765	Diabetic Amyotrophy	0.6%
766	Diabetic Autonomic Neuropathy	0.6%
767	Sleep Talking	0.6%
768	Manganese Poisoning	0.6%
769	Sleep Disorders, Intrinsic	0.6%
770	Orthostatic intolerance	0.6%
771	Anosmia	0.6%
772	Ataxia	0.6%
773	Athetosis	0.6%
774	Catalepsy	0.6%
775	Dystonia	0.6%
776	Hemiplegia	0.6%
777	Locked-In Syndrome	0.6%
778	Meningeal Neoplasms	0.6%
779	Muscle Hypertonia	0.6%
780	Muscle hypotonia	0.6%
781	Myoclonus	0.6%
782	Myotonia	0.6%
783	Neuralgia	0.6%
784	Paraplegia	0.6%
785	Pseudobulbar Palsy	0.6%
786	Quadriplegia	0.6%
787	Spasm	0.6%
788	Spastic Paraplegia	0.6%
789	Status Epilepticus	0.6%
790	Taste Disorders	0.6%
791	Tremor	0.6%
792	Monoplegia	0.6%
793	Hypokinesia	0.6%
794	Paraparesis	0.6%
795	Bradykinesia	0.6%
796	Waxy flexibility	0.6%
797	Action Tremor	0.6%
798	Resting Tremor	0.6%
799	Dysosmia	0.6%
800	Quadriparesis	0.6%
801	Mercury Poisoning, Nervous System	0.6%
802	Olfaction Disorders	0.6%
803	Myokymia	0.6%
804	Lead Poisoning, Nervous System	0.6%
805	Vestibular Neuronitis	0.6%
806	Somatosensory Disorders	0.6%
807	Neuropathic pain	0.6%
808	Hyperkinesia	0.6%
809	Intention tremor	0.6%
810	Gait Apraxia	0.6%
811	Hyperprolactinemia	0.6%
812	Subclavian Steal Syndrome	0.6%
813	Pick Disease of the Brain	0.6%
814	Micrognathism	0.6%
815	Pierre Robin Syndrome	0.6%
816	Hand-Arm Vibration Syndrome	0.5%
817	Vision Disorders	0.5%
818	Metamorphopsia	0.5%
819	Visual Impairment	0.5%
820	Fibromyalgia	0.5%
821	Optic Neuropathy, Ischemic	0.5%
822	Anterior Ischemic Optic Neuropathy	0.5%
823	Medial Tibial Stress Syndrome	0.5%
824	Multiple Sclerosis, Chronic Progressive	0.5%
825	Multiple Sclerosis, Relapsing-Remitting	0.5%
826	Facial Hemiatrophy	0.5%
827	Melkersson-Rosenthal Syndrome	0.5%
828	Anisocoria	0.5%
829	Confusion	0.5%
830	Facial paralysis	0.5%
831	Lethargy	0.5%
832	Memory Disorders	0.5%
833	Muscle Cramp	0.5%
834	Perceptual Disorders	0.5%
835	Psychomotor Disorders	0.5%
836	Tonic Pupil	0.5%
837	Eosinophilia-Myalgia Syndrome	0.5%
838	Anhedonia	0.5%
839	Disorientation	0.5%
840	Facial Paresis	0.5%
841	Memory Loss	0.5%
842	Hemisensory Neglect	0.5%
843	Dysacusis	0.5%
844	Sleep Bruxism	0.5%
845	Muscular Atrophy	0.5%
846	Respiratory Paralysis	0.5%
847	Lateral Medullary Syndrome	0.5%
848	Retrognathia	0.5%
849	West Nile Fever	0.5%
850	Acromegaly	0.5%
851	Sinus Thrombosis, Intracranial	0.5%
852	Folic Acid Deficiency	0.5%
853	Pellagra	0.5%
854	Thiamine Deficiency	0.5%
855	Vitamin B 12 Deficiency	0.5%
856	Vitamin B 6 Deficiency	0.5%
857	Pyridoxine Deficiency	0.5%
858	Consciousness Disorders	0.5%
859	Mental Retardation	0.5%
860	Muscle Weakness	0.5%
861	Depressed Level of Consciousness	0.5%
862	Mental deficiency	0.5%
863	Intellectual Disability	0.5%
864	Bell Palsy	0.5%
865	Catatonia	0.5%
866	Herpes Zoster Oticus	0.5%
867	Aphonia	0.5%
868	Sleep Deprivation	0.5%
869	Dysphonia	0.5%
870	Prognathism	0.5%
871	Myalgia	0.5%
872	Anterior Spinal Artery Syndrome	0.5%
873	Tarsal Tunnel Syndrome	0.4%
874	Cauda Equina Syndrome	0.4%
875	Prolactinoma	0.4%
876	Growth Hormone-Secreting Pituitary Adenoma	0.4%
877	Aortopulmonary Septal Defect	0.4%
878	Double Outlet Right Ventricle	0.4%
879	Endocardial Cushion Defects	0.4%
880	Myocardial bridging	0.4%
881	Aorticopulmonary Septal Defect	0.4%
882	Hoarseness	0.4%
883	Alcohol Withdrawal Delirium	0.4%
884	Waterhouse-Friderichsen Syndrome	0.4%
885	Scurvy	0.4%
886	Malaria, Cerebral	0.4%
887	Neurocysticercosis	0.4%
888	Carpal Tunnel Syndrome	0.4%
889	neurofibroma	0.4%
890	Mandibulofacial Dysostosis	0.4%
891	Romano-Ward Syndrome	0.4%
892	Sciatica	0.4%
893	Arteriovenous fistula	0.4%
894	Hematoma, Subdural, Intracranial	0.3%
895	Hematoma, Subdural, Chronic	0.3%
896	Hematoma, Subdural, Acute	0.3%
897	Sciatic Neuropathy	0.3%
898	Ulnar Neuropathies	0.3%
899	Lesion of Sciatic Nerve	0.3%
900	Ulnar Neuritis	0.3%
901	Radial nerve compression	0.3%
902	Radial Tunnel Syndrome	0.3%
903	Peroneal Neuropathies	0.3%
904	Radial Neuropathy	0.3%
905	Median Neuropathy	0.3%
906	Sciatic Nerve Palsy	0.3%
907	Femoral Neuropathy	0.3%
908	Tibial Neuropathy	0.3%
909	Ulnar Nerve Palsy	0.3%
910	Postural Orthostatic Tachycardia Syndrome	0.3%
911	Radial nerve palsy	0.3%
912	Beriberi	0.3%
913	Thoracic Outlet Syndrome	0.3%
914	Esotropia	0.3%
915	Exotropia	0.3%
916	Hypotension, Orthostatic	0.3%
917	Sleep Apnea Syndromes	0.3%
918	Polymyositis	0.3%
919	Post-Exercise Hypotension	0.3%
920	Disorders of Excessive Somnolence	0.3%
921	Sleep Initiation and Maintenance Disorders	0.3%
922	Night Terrors	0.3%
923	Somnambulism	0.3%
924	Trigeminal Nerve Disorder	0.3%
925	Transient Insomnia	0.3%
926	Sleep Paralysis	0.3%
927	Chronic Insomnia	0.3%
928	REM Sleep Behavior Disorder	0.3%
929	Hypersomnia	0.3%
930	Dysgeusia	0.3%
931	Formication	0.3%
932	Hyperalgesia	0.3%
933	Hyperesthesia	0.3%
934	Hypesthesia	0.3%
935	Language Disorders	0.3%
936	Numbness	0.3%
937	Paresthesia	0.3%
938	Paraparesis, Spastic	0.3%
939	Trismus	0.3%
940	Epilepsia Partialis Continua	0.3%
941	Hypogeusia	0.3%
942	Meningeal Carcinomatosis	0.3%
943	Brown-Sequard Syndrome	0.3%
944	Lockjaw	0.3%
945	Allodynia	0.3%
946	Lead Poisoning, Nervous System, Childhood	0.3%
947	Lead Poisoning, Nervous System, Adult	0.3%
948	Ageusia	0.3%
949	Cavernous Sinus Thrombosis	0.3%
950	Sagittal Sinus Thrombosis	0.3%
951	Anemia, Pernicious	0.3%
952	Cubital Tunnel Syndrome	0.3%
953	Eye Injuries	0.3%
954	Orbital Myositis	0.3%
955	Diplopia	0.3%
956	Muscle Rigidity	0.3%
957	Muscle Spasticity	0.3%
958	Scotoma	0.3%
959	Photophobia	0.3%
960	Cogwheel Rigidity	0.3%
961	Hemifacial Spasm	0.3%
962	Amaurosis	0.3%
963	Blindness	0.3%
964	Nuchal Rigidity	0.3%
965	Pyomyositis	0.3%
966	Agnosia	0.3%
967	Apraxias	0.3%
968	Hallucinations	0.3%
969	Hemianopsia	0.3%
970	Hyperacusis	0.3%
971	Tinnitus	0.3%
972	Visual Agnosia	0.3%
973	Anosognosia	0.3%
974	Wernicke-Korsakoff Syndrome	0.3%
975	Phonophobia	0.3%
976	Hearing Loss	0.3%
977	Sarcopenia	0.3%
978	Nelson Syndrome	0.3%
979	Amnesia	0.3%
980	Delirium	0.3%
981	Dissociative Amnesia	0.3%
982	Color blindness	0.3%
983	Global Amnesia	0.3%
984	Meningioma	0.3%
985	Truncus Arteriosus, Persistent	0.2%
986	Goldenhar Syndrome	0.2%
987	Alexia	0.2%
988	Dyslexia	0.2%
989	Phantom pain	0.2%
990	Phantom Limb Pain	0.2%
991	Talipes	0.2%
992	Neurofibrosarcoma	0.2%
993	Polyradiculopathy	0.2%
994	Sleep Apnea, Obstructive	0.2%
995	Sleep Apnea, Central	0.2%
996	Narcolepsy	0.2%
997	Trigeminal Neuralgia	0.2%
998	Kleine-Levin Syndrome	0.2%
999	Agraphia	0.2%
1000	Anomia	0.2%
1001	Cluttering	0.2%
1002	Language Development Disorders	0.2%
1003	Speech Disorders	0.2%
1004	Syncope	0.2%
1005	Stupor	0.2%
1006	Dysgraphia	0.2%
1007	Presyncope	0.2%
1008	Dyslalia	0.2%
1009	Eye Burns	0.1%
1010	Amaurosis Fugax	0.1%
1011	Blindness, Cortical	0.1%
1012	Dyscalculia	0.1%
1013	Deafness	0.1%
1014	Hearing Loss, Sudden	0.1%
1015	Gerstmann Syndrome	0.1%
1016	Hearing Loss, Bilateral	0.1%
1017	Hearing Loss, High-Frequency	0.1%
1018	Hearing Loss, Mixed Conductive-Sensorineural	0.1%
1019	Prosopagnosia	0.1%
1020	Apraxia, Ideomotor	0.1%
1021	Charles Bonnet Syndrome	0.1%
1022	Hearing Loss, Unilateral	0.1%
1023	Complete Hearing Loss	0.1%
1024	Alien Hand Syndrome	0.1%
1025	Deaf Mutism	0.1%
1026	Congenital clubfoot	0.1%
1027	Vertical Talus	0.1%
1028	Dermatomyositis	0.1%
1029	Corneal Scar	0.1%
1030	Retrograde amnesia	0.1%
1031	Amnesia, Anterograde	0.1%
1032	Cataplexy	0.1%
1033	Aphasia	0.1%
1034	Articulation Disorders	0.1%
1035	Echolalia	0.1%
1036	Stuttering	0.1%
1037	Dysphasia	0.1%
1038	Mutism	0.1%
1039	Selective Mutism	0.1%
1040	Corneal Perforation	0.1%
1041	Dysarthria	0%
1042	Alexia, Pure	0%

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