MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Vitamin E Deficiency

(UMLS:C0042875)

Definition:: A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)
UMLS ID:: C0042875
MeSH ID:: D014811

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.841

Synonym(s)

Vitamin E Deficiency

Alpha-tocopherol deficiency

Deficiency of vitamin E

Hypovitaminosis E

Low levels of vitamin E

Vitamin E deficiency

Vitamin E deficiency disease

deficiency e vitamin

deficiency of vitamin e

10.

deficiency vitamin e

11.

deficiency; vitamin, E

12.

of vitamin e deficiency

13.

vitamin E deficiency

14.

vitamin e deficiency

15.

vitamin; deficiency, E

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Octreotide	FAERS: 1		US FAERS
2	Quetiapine Fumarate	FAERS: 1		US FAERS
3	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
4	niraparib	FAERS: 1		US FAERS
5	Alcohols		4735055	CTD
6	Anastrozole			OFFSIDES
7	Tocopherols		7946427	CTD
8	Vitamin E		572510	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Ascorbic Acid Deficiency	49.2%
2	Vitamin A Deficiency	49.2%
3	Vitamin D Deficiency	49.2%
4	Folic Acid Deficiency	36.8%
5	Pellagra	36.8%
6	Thiamine Deficiency	36.8%
7	Vitamin B 12 Deficiency	36.8%
8	Vitamin B 6 Deficiency	36.8%
9	Pyridoxine Deficiency	36.8%
10	Magnesium Deficiency	36%
11	Potassium Deficiency	36%
12	Protein Deficiency	36%
13	Beriberi	30.6%
14	Starvation	28.5%
15	Refeeding Syndrome	28.5%
16	Vitamin K Deficiency	25.2%
17	Marasmus	23.8%
18	Child Nutrition Disorders	22.7%
19	Hypervitaminosis A	22.7%
20	Infant Nutrition Disorders	22.7%
21	Wasting Syndrome	20.6%
22	Anemia, Pernicious	20.4%
23	Scurvy	18.7%
24	Rickets	18.4%
25	Hyperhomocysteinemia	17.6%
26	Kwashiorkor	16.8%
27	Metabolic Diseases	15.3%
28	Osteomalacia	14.3%
29	Wernicke Encephalopathy	11.9%
30	Subacute Combined Degeneration	10.8%
31	Renal Osteodystrophy	9%
32	Renal rickets	9%
33	Acid-Base Imbalance	7.6%
34	Calcium Metabolism Disorders	7.6%
35	Iron Metabolism Disorders	7.6%
36	Phosphorus Metabolism Disorders	7.6%
37	Water-Electrolyte Imbalance	7.6%
38	Lipid Metabolism Disorders	7.6%
39	Mitochondrial Diseases	7.6%
40	Glucose Metabolism Disorders	7.6%
41	Familial Hypophosphatemic Rickets	5.7%
42	Hypercalcemia	5.5%
43	Hypocalcemia	5.5%
44	Milk-Alkali Syndrome	5.5%
45	HIV Wasting Syndrome	5.4%
46	Osteopenia	5.1%
47	Brain Diseases, Metabolic	5%
48	Obesity	4.8%
49	Lipodystrophy	4.1%
50	Acidosis	4.1%
51	Alkalosis	4.1%
52	Amyloidosis	4.1%
53	Calcinosis	4.1%
54	Hyperglycemia	4.1%
55	Hyperinsulinism	4.1%
56	Hyperkalemia	4.1%
57	Hypernatremia	4.1%
58	Hypoglycemia	4.1%
59	Hypokalemia	4.1%
60	Hyponatremia	4.1%
61	Xanthomatosis	4.1%
62	Hypophosphatemia	4.1%
63	Metabolic acidosis	4.1%
64	Dyslipidemias	4.1%
65	Iron Overload	4.1%
66	Xanthoma	4.1%
67	Obesity, Abdominal	3.6%
68	Pseudohypoparathyroidism	3.5%
69	Brain Diseases, Metabolic, Inborn	3.3%
70	Diabetes Mellitus	2.9%
71	Pediatric Obesity	2.9%
72	Dehydration	2.8%
73	Lipomatosis	2.8%
74	Water Intoxication	2.8%
75	Werner Syndrome	2.8%
76	Achlorhydria	2.7%
77	Amino Acid Metabolism, Inborn Errors	2.7%
78	Bloom Syndrome	2.7%
79	Carbohydrate Metabolism, Inborn Errors	2.7%
80	Metal Metabolism, Inborn Errors	2.7%
81	Osteoporosis	2.7%
82	Progeria	2.7%
83	Lysosomal Storage Diseases	2.7%
84	Bone Demineralization, Pathologic	2.7%
85	Cytochrome-c Oxidase Deficiency	2.7%
86	Peroxisomal Disorders	2.7%
87	Post-Traumatic Osteoporosis	2.7%
88	Celiac Disease	2.7%
89	Sprue, Tropical	2.7%
90	Steatorrhea	2.7%
91	Sprue	2.7%
92	Leigh Disease	2.6%
93	Lactose Intolerance	2.6%
94	Prader-Willi Syndrome	2.5%
95	Hypolipoproteinemias	2.4%
96	Acidosis, Lactic	2.4%
97	Calciphylaxis	2.4%
98	Hemosiderosis	2.4%
99	Ketosis	2.4%
100	Ketonuria	2.4%
101	Ketoacidosis	2.4%
102	Ketonemia	2.4%
103	Vascular calcification	2.4%
104	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.2%
105	Mitochondrial Encephalomyopathies	2.2%
106	Mitochondrial Myopathies	2.1%
107	Smith-Lemli-Opitz Syndrome	2.1%
108	Myelinolysis, Central Pontine	2.1%
109	Galactosemias	2.1%
110	Urea Cycle Disorders, Inborn	2.1%
111	Tyrosinemias	2.1%
112	Glycosuria	2%
113	Reye Syndrome	2%
114	Hepatic Encephalopathy	2%
115	Diabetic Ketoacidosis	2%
116	Congenital Hyperinsulinism	2%
117	Hyperlipidemia, Familial Combined	2%
118	Hyperlipoproteinemia Type IV	1.9%
119	Hyperlipoproteinemia Type V	1.9%
120	Hyperphosphaturia	1.8%
121	Hyperlipoproteinemia Type III	1.8%
122	Porphyrias, Hepatic	1.7%
123	Necrobiosis Lipoidica Diabeticorum	1.6%
124	Acidosis, Respiratory	1.6%
125	Adiposis Dolorosa	1.6%
126	Alkalosis, Respiratory	1.6%
127	Homocystinuria	1.6%
128	Fanconi Anemia	1.6%
129	Renal tubular acidosis	1.6%
130	Alkaptonuria	1.6%
131	Glycogen Storage Disease	1.6%
132	Hypophosphatasia	1.6%
133	Insulin Resistance	1.6%
134	Osteoporosis, Postmenopausal	1.6%
135	Propionic acidemia	1.6%
136	Dihydropyrimidine Dehydrogenase Deficiency	1.6%
137	Cystinosis	1.6%
138	Hypercholesterolemia	1.6%
139	Hyperlipoproteinemias	1.6%
140	Hypertriglyceridemia	1.6%
141	Hypoalphalipoproteinemias	1.6%
142	Amyloid Neuropathies, Familial	1.4%
143	Glycogen storage disease type II	1.4%
144	HIV-Associated Lipodystrophy Syndrome	1.4%
145	Neuronal Ceroid-Lipofuscinoses	1.3%
146	Friedreich Ataxia	1.3%
147	Zellweger Syndrome	1.3%
148	Menkes Kinky Hair Syndrome	1.3%
149	Nesidioblastosis	1.3%
150	MELAS Syndrome	1.3%
151	Gestational Diabetes	1.3%
152	Latent Autoimmune Diabetes in Adults	1.3%
153	Gaucher Disease	1.3%
154	Diabetes Mellitus, Experimental	1.2%
155	Adrenoleukodystrophy	1.2%
156	Hepatolenticular Degeneration	1.2%
157	Nephrocalcinosis	1.2%
158	Tetany	1.2%
159	Refsum Disease	1.2%
160	Glycosuria, Renal	1.2%
161	Cerebral Amyloid Angiopathy	1.2%
162	Kernicterus	1.2%
163	Cockayne Syndrome	1.2%
164	Mucopolysaccharidosis III	1.1%
165	Glycogen Storage Disease Type I	1.1%
166	Glycogen Storage Disease Type V	1.1%
167	Ataxia Telangiectasia	1%
168	Kearns-Sayre syndrome	1%
169	Optic Atrophy, Hereditary, Leber	1%
170	Familial Periodic Paralysis	1%
171	Primary amyloidosis	1%
172	Fabry Disease	1%
173	Variegate Porphyria	1%
174	Acute intermittent porphyria	1%
175	Porphyria Cutanea Tarda	1%
176	Renal Aminoacidurias	1%
177	Fanconi Syndrome	1%
178	Pseudohypoaldosteronism	1%
179	Liddle Syndrome	1%
180	Niemann-Pick Disease, Type C	0.9%
181	Xeroderma Pigmentosum	0.9%
182	Tay-Sachs Disease	0.9%
183	Gout	0.8%
184	Amyotrophic Lateral Sclerosis	0.8%
185	Sjogren-Larsson Syndrome	0.8%
186	Antley-Bixler Syndrome Phenotype	0.8%
187	Canavan Disease	0.7%
188	Alexander Disease	0.7%
189	Mucopolysaccharidosis II	0.7%
190	CREST Syndrome	0.7%
191	Hypokalemic periodic paralysis	0.6%
192	Frontotemporal dementia	0.6%
193	Cystinuria	0.6%
194	Albinism	0.6%
195	Arthritis, Gouty	0.5%
196	Ichthyosis, X-Linked	0.5%

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