MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Sleep Apnea, Central

(UMLS:C0520680)

Definition:: A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, OBSTRUCTIVE) by the complete cessation of efforts to breathe. This disorder is associated with dysfunction of central nervous system centers that regulate respiration.
UMLS ID:: C0520680
MeSH ID:: D020182

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.618.085.852.800

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.886.425.800.750.800

Synonym(s)

Sleep Apnea, Central

APNEA, CENTRAL SLEEP

CSA - Central sleep apnea

CSA - Central sleep apnoea

Central Sleep Apnea

Central sleep apnea

Central sleep apnoea

apnea central sleep

central alveolar hypoventilation

10.

central sleep apnea

11.

central sleep apnoea

12.

ondine syndrome

13.

sleep apnea central

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acetazolamide	9696283	CTD
2	Analgesics, Opioid	16243902	CTD
3	Dexmedetomidine	16243902	CTD
4	Methadone	11255580 16162728	CTD
5	Morphine	2334618	CTD
6	Ouabain	8458769	CTD
7	Promethazine	3991270	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Sleep Apnea, Obstructive	48.8%
2	Nocturnal Myoclonus Syndrome	24.3%
3	Restless Legs Syndrome	18.5%
4	Disorders of Excessive Somnolence	18.1%
5	Sleep Initiation and Maintenance Disorders	18.1%
6	Transient Insomnia	18.1%
7	Chronic Insomnia	18.1%
8	Hypersomnia	18.1%
9	Respiratory Distress Syndrome, Adult	16.9%
10	Altitude Sickness	16.6%
11	Respiratory Insufficiency	16.6%
12	Respiratory Depression	16.6%
13	Respiratory Failure	16.6%
14	Vocal Cord Dysfunction	13.7%
15	Respiratory Distress Syndrome, Newborn	13.5%
16	Respiratory Aspiration	12.7%
17	Sleep Disorders, Circadian Rhythm	12.6%
18	Cheyne-Stokes Respiration	12.4%
19	Dyspnea	12.4%
20	Hyperventilation	12.4%
21	Mouth Breathing	12.4%
22	Tachypnea	12.4%
23	Narcolepsy	12%
24	Kleine-Levin Syndrome	12%
25	Parasomnia	11.4%
26	Bronchial Diseases	10.4%
27	Lung diseases	10.4%
28	Pleural Diseases	10.4%
29	Thoracic Diseases	10.4%
30	Tracheal Diseases	10.4%
31	Cranial nerve diseases	9.8%
32	Demyelinating Diseases	9.8%
33	Demyelination	9.8%
34	Neuromuscular Diseases	9.8%
35	Chronobiology Disorders	9.8%
36	Airway Obstruction	9.7%
37	Choking	9.7%
38	Sleep Deprivation	9.5%
39	Granuloma, Laryngeal	9.2%
40	Cataplexy	8.9%
41	Bronchitis	8.8%
42	Meconium Aspiration Syndrome	8.7%
43	Tracheobronchomegaly	8.5%
44	Hoarseness	8.5%
45	Pleurisy	8.4%
46	Pneumonia	8.4%
47	Lobar Pneumonia	8.4%
48	Tracheitis	8.4%
49	Pneumonitis	8.4%
50	Acute Chest Syndrome	8.2%
51	Laryngeal Diseases	8.1%
52	Nose Diseases	8.1%
53	Laryngospasm	7.9%
54	Respiratory Tract Infections	7.9%
55	Hyaline Membrane Disease	7.8%
56	Granuloma, Respiratory Tract	7.7%
57	Respiratory Hypersensitivity	7.7%
58	Respiratory Tract Fistula	7.7%
59	Trauma, Nervous System	7.7%
60	Motor Neuron Disease	7.6%
61	Respiratory Paralysis	7.5%
62	Nervous System Neoplasms	7.4%
63	Neurologic Manifestations	7.4%
64	Neurotoxicity Syndromes	7.4%
65	Hypoventilation	7.3%
66	Bronchopneumonia	7.3%
67	Acidosis, Respiratory	7.3%
68	Alkalosis, Respiratory	7.3%
69	Asthma	7.2%
70	Jet Lag Syndrome	7.1%
71	Laryngitis	6.8%
72	Lung Diseases, Fungal	6.8%
73	Rhinitis	6.8%
74	Bronchial Fistula	6.7%
75	Lung Abscess	6.7%
76	Lung Neoplasms	6.7%
77	Pleural Neoplasms	6.7%
78	Tuberculosis, Pulmonary	6.7%
79	Pleuropneumonia	6.6%
80	Stiff-Person Syndrome	6.4%
81	Ocular Motility Disorders	6.3%
82	Cyclophoria	6.3%
83	Sleep Talking	6.1%
84	Multiple System Atrophy	6.1%
85	Dyspnea, Paroxysmal	5.9%
86	Polyradiculoneuropathy	5.8%
87	Polyradiculoneuritis	5.8%
88	Encephalomyelitis	5.8%
89	Prion Diseases	5.8%
90	Autonomic Dysreflexia	5.8%
91	Complex Regional Pain Syndromes	5.8%
92	Choanal Atresia	5.7%
93	Laryngocele	5.7%
94	Tracheal Neoplasms	5.6%
95	Atelectasis	5.5%
96	Bronchospasm	5.5%
97	Bronchiectasis	5.5%
98	Chylothorax	5.5%
99	Hydropneumothorax	5.5%
100	Hydrothorax	5.5%
101	Pulmonary Hypertension	5.5%
102	Pneumothorax	5.5%
103	Pulmonary Alveolar Proteinosis	5.5%
104	Pulmonary Edema	5.5%
105	Pulmonary Fibrosis	5.5%
106	Tracheal Stenosis	5.5%
107	Bronchial Hyperreactivity	5.5%
108	Hamman-Rich syndrome	5.5%
109	Lung Diseases, Interstitial	5.5%
110	Lung Diseases, Obstructive	5.5%
111	Subacute Combined Degeneration	5.5%
112	Bronchitis, Chronic	5.4%
113	Voice Disorders	5.4%
114	Voice Disturbance	5.4%
115	Sinusitis	5.3%
116	Bronchial Neoplasms	5.3%
117	Primary Ciliary Dyskinesia	5.2%
118	Bronchiolitis	5.2%
119	Brain Diseases	5%
120	Dysautonomia	5%
121	Meningitis	5%
122	Movement Disorders	5%
123	Pachymeningitis	5%
124	Spinal Cord Diseases	5%
125	Vagus Nerve Disorder	5%
126	Glossopharyngeal Neuralgia	5%
127	Abducens Nerve Diseases	5%
128	Heavy Metal Poisoning, Nervous System	5%
129	Neuromuscular Junction Diseases	5%
130	Tauopathies	5%
131	Trochlear Nerve Diseases	5%
132	Peripheral Nervous System Diseases	5%
133	Marchiafava-Bignami Disease	4.9%
134	Spinal Muscular Atrophy	4.9%
135	Sleep Bruxism	4.9%
136	Progressive Muscular Atrophy	4.9%
137	Aspiration Pneumonia	4.9%
138	Pleural Effusion, Malignant	4.9%
139	Laryngeal neoplasm	4.9%
140	Spinal Cord Injuries	4.8%
141	Vocal Cord Paralysis	4.8%
142	Peripheral Nerve Injuries	4.7%
143	Amyotrophic Lateral Sclerosis	4.7%
144	Aspergillosis, Allergic Bronchopulmonary	4.7%
145	Ophthalmoplegic Migraine	4.7%
146	Myasthenia Gravis	4.7%
147	Asterixis	4.7%
148	Ballismus	4.7%
149	Parkinson Disease	4.6%
150	Meningoencephalitis	4.3%
151	Granuloma, Lethal Midline	4.2%
152	Laryngeal Edema	4.2%
153	Nose Deformities, Acquired	4.2%
154	Lung Injury	4.2%
155	Hepatopulmonary Syndrome	4.2%
156	Scimitar Syndrome	4.2%
157	Common Cold	4.1%
158	Hemothorax	4.1%
159	Influenza	4.1%
160	Catarrh	4.1%
161	Pulmonary Embolism	4.1%
162	Dandy-Walker Syndrome	4.1%
163	Pulmonary Eosinophilia	4.1%
164	Severe Acute Respiratory Syndrome	4.1%
165	Eosinophilic Pneumonia	4.1%
166	Pneumoconiosis	4.1%
167	Pneumonia, Viral	4.1%
168	Laryngopharyngeal Reflux	4.1%
169	Pneumocephalus	4.1%
170	Poliomyelitis	4.1%
171	Myelitis	4.1%
172	Progressive bulbar palsy	4.1%
173	Bulbar palsy	4.1%
174	Chronic Fatigue Syndrome	4.1%
175	Idiopathic Pulmonary Fibrosis	4%
176	Pneumonia, Bacterial	4%
177	Lewy Body Disease	4%
178	Neuroleptic Malignant Syndrome	4%
179	Myelinolysis, Central Pontine	4%
180	Guillain-Barre Syndrome	4%
181	Lambert-Eaton Myasthenic Syndrome	3.9%
182	Central Nervous System Infection	3.9%
183	Myopathy	3.9%
184	Optic Neuropathy	3.9%
185	Asthma, Exercise-Induced	3.9%
186	Status Asthmaticus	3.9%
187	Multiple Pulmonary Nodules	3.9%
188	Botulism	3.9%
189	Central Nervous System Cysts	3.9%
190	Facial Nerve Diseases	3.8%
191	Craniocerebral Trauma	3.8%
192	Nose Neoplasms	3.7%
193	Vestibulocochlear Nerve Diseases	3.7%
194	Decerebrate State	3.7%
195	Hemiparesis	3.7%
196	Hydranencephaly	3.7%
197	Meningism	3.7%
198	Neural Tube Defects	3.7%
199	Paresis	3.7%
200	Seizures	3.7%
201	Sensation Disorders	3.7%
202	Tethered Cord Syndrome	3.7%
203	Central Nervous System Neoplasms	3.7%
204	Complex partial seizures	3.7%
205	Iniencephaly	3.7%
206	Craniorachischisis	3.7%
207	Exencephaly	3.7%
208	Monoparesis	3.7%
209	Septo-Optic Dysplasia	3.7%
210	Cortical Dysplasia	3.7%
211	Neurogenic Inflammation	3.7%
212	Gait Disorders, Neurologic	3.7%
213	Neuromuscular Manifestations	3.7%
214	Malformations of Cortical Development	3.7%
215	Rhinoscleroma	3.7%
216	Sweating, Gustatory	3.7%
217	Auriculotemporal Syndrome	3.7%
218	Night Terrors	3.6%
219	Somnambulism	3.6%
220	Sleep Paralysis	3.6%
221	REM Sleep Behavior Disorder	3.6%
222	Causalgia	3.6%
223	Dyskinesia, Drug-Induced	3.5%
224	Epidural Abscess	3.5%
225	Olfactory Nerve Injuries	3.5%
226	Striatonigral Degeneration	3.5%
227	Progressive supranuclear palsy	3.4%
228	Myelitis, Transverse	3.4%
229	Pharyngitis	3.4%
230	MPTP Poisoning	3.4%
231	Asthma, Occupational	3.4%
232	Laryngostenosis	3.4%
233	Nasal Polyps	3.4%
234	Akathisia, Drug-Induced	3.3%
235	Hemoptysis	3.3%
236	Radiation Pneumonitis	3.3%
237	Radiation Fibrosis	3.3%
238	Opsoclonus-Myoclonus Syndrome	3.3%
239	Pertussis	3.3%
240	Paranasal Sinus Neoplasms	3.3%
241	Horner Syndrome	3.3%
242	Brain Injuries	3.3%
243	Brain Neoplasms	3.3%
244	Multiple Sclerosis	3.3%
245	Spinal Cord Neoplasms	3.3%
246	Encephalomyelitis, Acute Disseminated	3.2%
247	Epiglottitis	3.2%
248	Chronic Obstructive Airway Disease	3.2%
249	Mediastinitis	3.2%
250	Middle Lobe Syndrome	3.2%
251	Acute Lung Injury	3.2%
252	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.2%
253	Reflex Sympathetic Dystrophy	3.2%
254	Subdural Effusion	3.2%
255	Parkinsonian Disorders	3.2%
256	Pneumonia, Lipid	3.2%
257	Leukoencephalitis, Acute Hemorrhagic	3.1%
258	Pupil Disorders	3.1%
259	Neurobehavioral Manifestations	3.1%
260	Neuromyelitis Optica	3.1%
261	Kartagener Syndrome	3.1%
262	Facial Nerve Injuries	3%
263	Paraneoplastic Encephalomyelitis	3%
264	Shy-Drager Syndrome	3%
265	Miller Fisher Syndrome	3%
266	Aphonia	3%
267	Dysphonia	3%
268	Uveomeningoencephalitic Syndrome	3%
269	Dystonia Musculorum Deformans	3%
270	Sturge-Weber Syndrome	3%
271	Vertigo	3%
272	Alcohol-Induced Disorders, Nervous System	3%
273	Cystic Fibrosis	2.9%
274	Vasculitis, Central Nervous System	2.8%
275	Asthma, Aspirin-Induced	2.8%
276	Epistaxis	2.8%
277	Bronchiolitis Obliterans	2.8%
278	Brain Abscess	2.8%
279	Ophthalmoplegia	2.8%
280	External Ophthalmoplegia	2.8%
281	Farmer's Lung	2.7%
282	Akinetic Mutism	2.7%
283	Anoxic Encephalopathy	2.7%
284	Arachnoiditis	2.7%
285	Basal Ganglia Diseases	2.7%
286	Brain Damage, Chronic	2.7%
287	Cerebellar Diseases	2.7%
288	Encephalitis	2.7%
289	Encephalomalacia	2.7%
290	Epilepsy	2.7%
291	Hydrocephalus	2.7%
292	Congenital Hydrocephalus	2.7%
293	Hypothalamic Diseases	2.7%
294	Aseptic Meningitis	2.7%
295	Neuritis	2.7%
296	Polyneuritis	2.7%
297	Radiculitis	2.7%
298	Syringomyelia	2.7%
299	Thalamic Diseases	2.7%
300	Intracranial Hypertension	2.7%
301	Polyneuropathy	2.7%
302	Mononeuritis	2.7%
303	Aura	2.7%
304	Leukoencephalopathy	2.7%
305	Essential Tremor	2.7%
306	Neuroaxonal Dystrophies	2.7%
307	Familial Tremor	2.7%
308	Headache Disorders	2.7%
309	Mononeuropathies	2.7%
310	Intracranial Hypotension	2.7%
311	Brachial Plexus Neuropathies	2.7%
312	Radiculopathy	2.7%
313	Mononeuropathy Multiplex	2.7%
314	Nerve Root Compression	2.7%
315	Brain Edema	2.7%
316	Brain Hypoxia	2.7%
317	Aqueductal Stenosis	2.7%
318	Pneumorrhachis	2.7%
319	Writer's Cramp	2.7%
320	Hay fever	2.7%
321	Rhinitis, Allergic, Perennial	2.7%
322	Scrapie	2.6%
323	Central Cord Syndrome	2.6%
324	Myasthenia Gravis, Autoimmune, Experimental	2.6%
325	Leukoencephalopathy, Progressive Multifocal	2.6%
326	Asbestosis	2.6%
327	Berylliosis	2.6%
328	Silicosis	2.6%
329	Presenile dementia	2.6%
330	Senile dementia	2.6%
331	Meningitis, Bacterial	2.6%
332	Meningitis, Fungal	2.6%
333	Tuberous Sclerosis	2.6%
334	Chorea	2.6%
335	Acrodynia	2.6%
336	Limbic Encephalitis	2.6%
337	Smith-Magenis syndrome	2.5%
338	Mediastinal Cyst	2.5%
339	Pericardial Cyst	2.5%
340	Persistent Fetal Circulation Syndrome	2.5%
341	Thymic Cyst	2.5%
342	Dural Arteriovenous Fistula	2.5%
343	Blastomycosis	2.5%
344	Croup	2.4%
345	Histiocytosis, Langerhans-Cell	2.4%
346	Mediastinal Emphysema	2.4%
347	Rhinitis, Vasomotor	2.4%
348	Pulmonary Aspergillosis	2.4%
349	Bronchopulmonary Aspergillosis	2.4%
350	Sarcoidosis, Pulmonary	2.4%
351	Laryngomalacia	2.4%
352	Pulmonary Infarction	2.4%
353	Epilepsy, Post-Traumatic	2.4%
354	Meige Syndrome	2.4%
355	Brachial Plexus Neuritis	2.4%
356	Neuralgic Amyotrophy	2.4%
357	Cerebral Ventriculitis	2.4%
358	Huntington Disease	2.4%
359	Charcot-Marie-Tooth Disease	2.3%
360	Ataxia Telangiectasia	2.2%
361	Amblyopia	2.2%
362	Myotonia Congenita	2.2%
363	Canavan Disease	2.2%
364	Alexander Disease	2.2%
365	Paraneoplastic Cerebellar Degeneration	2.2%
366	Cerebrospinal Fluid Otorrhea	2.2%
367	Cerebrospinal Fluid Rhinorrhea	2.2%
368	Neuritis, Autoimmune, Experimental	2.2%
369	Gait Ataxia	2.2%
370	Maxillary Sinus Neoplasms	2.1%
371	Pulmonary Emphysema	2.1%
372	Lupus Vasculitis, Central Nervous System	2.1%
373	Reflex, Abnormal	2.1%
374	Hyporeflexia	2.1%
375	Hyperreflexia	2.1%
376	Brain Death	2.1%
377	Coma, Post-Head Injury	2.1%
378	Brain Diseases, Metabolic	2.1%
379	Cerebrovascular Disorders	2.1%
380	Myositis	2.1%
381	Optic Atrophy	2.1%
382	Optic Neuritis	2.1%
383	Papilledema	2.1%
384	Strabismus	2.1%
385	Tolosa-Hunt Syndrome	2.1%
386	Cerebrovascular Insufficiency	2.1%
387	Isaacs syndrome	2.1%
388	Arsenic Poisoning	2.1%
389	Dementia	2.1%
390	Myotonic Disorders	2.1%
391	Central Nervous System Fungal Infections	2.1%
392	Conus Medullaris Syndrome	2.1%
393	Myasthenic Syndromes, Congenital	2.1%
394	Spinal Cord Vascular Diseases	2.1%
395	Diabetic Neuropathies	2%
396	Facial Injuries	2%
397	Facial Neuralgia	2%
398	Diabetic Amyotrophy	2%
399	Diabetic Autonomic Neuropathy	2%
400	Manganese Poisoning	2%
401	Orthostatic intolerance	2%
402	Alcohol Withdrawal Seizures	2%
403	Anosmia	2%
404	Ataxia	2%
405	Athetosis	2%
406	Catalepsy	2%
407	Dystonia	2%
408	Hemiplegia	2%
409	Locked-In Syndrome	2%
410	Meningeal Neoplasms	2%
411	Meningomyelocele	2%
412	Muscle Hypertonia	2%
413	Muscle hypotonia	2%
414	Myoclonus	2%
415	Myotonia	2%
416	Neuralgia	2%
417	Paraplegia	2%
418	Pseudobulbar Palsy	2%
419	Quadriplegia	2%
420	Spasm	2%
421	Spastic Paraplegia	2%
422	Status Epilepticus	2%
423	Taste Disorders	2%
424	Tremor	2%
425	Spina Bifida	2%
426	Monoplegia	2%
427	Hypokinesia	2%
428	Paraparesis	2%
429	Bradykinesia	2%
430	Waxy flexibility	2%
431	Action Tremor	2%
432	Resting Tremor	2%
433	Dysosmia	2%
434	Quadriparesis	2%
435	Mercury Poisoning, Nervous System	2%
436	Olfaction Disorders	2%
437	Myokymia	2%
438	Lead Poisoning, Nervous System	2%
439	Vestibular Neuronitis	2%
440	Somatosensory Disorders	2%
441	Neuropathic pain	2%
442	Hyperkinesia	2%
443	Intention tremor	2%
444	Lafora Disease	2%
445	Unverricht-Lundborg Syndrome	2%
446	Tarsal Tunnel Syndrome	2%
447	Cauda Equina Syndrome	2%
448	Posterior Leukoencephalopathy Syndrome	2%
449	Posterior reversible encephalopathy syndrome	2%
450	Tonsillitis	2%
451	Granulomatosis with polyangiitis	1.9%
452	Creutzfeldt-Jakob disease	1.9%
453	Basal Ganglia Cerebrovascular Disease	1.9%
454	Brain Injuries, Diffuse	1.9%
455	Traumatic Brain Injury	1.9%
456	Cerebellar Ataxia	1.9%
457	Supratentorial Neoplasms	1.9%
458	Torticollis	1.9%
459	Multiple Sclerosis, Chronic Progressive	1.9%
460	Multiple Sclerosis, Relapsing-Remitting	1.9%
461	Hepatolenticular Degeneration	1.9%
462	Dementia, Vascular	1.9%
463	Brain Hemorrhage, Traumatic	1.9%
464	Cerebellar Neoplasms	1.9%
465	Akathisia	1.9%
466	Restlessness	1.9%
467	Psychomotor Agitation	1.9%
468	Friedreich Ataxia	1.8%
469	Carotid Artery Injuries	1.8%
470	Myotonic Dystrophy	1.8%
471	Hand-Arm Vibration Syndrome	1.7%
472	Vision Disorders	1.7%
473	Metamorphopsia	1.7%
474	Visual Impairment	1.7%
475	Fibromyalgia	1.7%
476	Optic Neuropathy, Ischemic	1.7%
477	Anterior Ischemic Optic Neuropathy	1.7%
478	Central Nervous System Bacterial Infections	1.7%
479	Medial Tibial Stress Syndrome	1.7%
480	Facial Hemiatrophy	1.7%
481	Melkersson-Rosenthal Syndrome	1.7%
482	Mitochondrial Myopathies	1.7%
483	Anisocoria	1.7%
484	Confusion	1.7%
485	Facial paralysis	1.7%
486	Lethargy	1.7%
487	Memory Disorders	1.7%
488	Muscle Cramp	1.7%
489	Perceptual Disorders	1.7%
490	Psychomotor Disorders	1.7%
491	Tonic Pupil	1.7%
492	Eosinophilia-Myalgia Syndrome	1.7%
493	Anhedonia	1.7%
494	Disorientation	1.7%
495	Facial Paresis	1.7%
496	Memory Loss	1.7%
497	Hemisensory Neglect	1.7%
498	Dysacusis	1.7%
499	Retropharyngeal Abscess	1.6%
500	Anti-Glomerular Basement Membrane Disease	1.6%
501	Anencephaly	1.6%
502	Meningocele	1.6%
503	Muscular Atrophy	1.6%
504	Encephalocele	1.6%
505	Leukomalacia, Periventricular	1.6%
506	Bronchomalacia	1.6%
507	Tracheomalacia	1.6%
508	Vertebral Artery Dissection	1.6%
509	Bronchopulmonary Dysplasia	1.6%
510	Tetany	1.6%
511	Amnesia, Transient Global	1.6%
512	Carpal Tunnel Syndrome	1.6%
513	Vascular Headaches	1.6%
514	Gait Apraxia	1.6%
515	Cerebral Palsy	1.6%
516	Epilepsies, Partial	1.6%
517	Epilepsy, Generalized	1.6%
518	Pseudotumor Cerebri	1.6%
519	Sciatic Neuropathy	1.6%
520	Hypertensive Encephalopathy	1.6%
521	Ulnar Neuropathies	1.6%
522	Lesion of Sciatic Nerve	1.6%
523	Simple Partial Seizures	1.6%
524	Epilepsy, Reflex	1.6%
525	Ulnar Neuritis	1.6%
526	Radial nerve compression	1.6%
527	Radial Tunnel Syndrome	1.6%
528	Peroneal Neuropathies	1.6%
529	Radial Neuropathy	1.6%
530	Median Neuropathy	1.6%
531	Sciatic Nerve Palsy	1.6%
532	Femoral Neuropathy	1.6%
533	Tibial Neuropathy	1.6%
534	Ulnar Nerve Palsy	1.6%
535	Postural Orthostatic Tachycardia Syndrome	1.6%
536	Radial nerve palsy	1.6%
537	Headache Disorders, Primary	1.6%
538	Headache Disorders, Secondary	1.6%
539	Medication overuse headache	1.6%
540	neurofibroma	1.6%
541	Hypoxia-Ischemia, Brain	1.6%
542	Sciatica	1.6%
543	Tardive Dyskinesia	1.6%
544	Tuberculosis, Meningeal	1.6%
545	Persistent Vegetative State	1.6%
546	Myoclonic Epilepsy	1.6%
547	Epilepsy, Temporal Lobe	1.6%
548	Epilepsy, Rolandic	1.6%
549	Benign Rolandic Epilepsy	1.6%
550	Alice in Wonderland Syndrome	1.5%
551	Refsum Disease	1.5%
552	Alstrom Syndrome	1.5%
553	Acoustic Neuroma	1.5%
554	Optic Nerve Glioma	1.5%
555	Toxoplasmosis, Cerebral	1.4%
556	Amyloid Neuropathies, Familial	1.4%
557	Nasopharyngitis	1.4%
558	Brain Concussion	1.4%
559	Duane Retraction Syndrome	1.4%
560	Consciousness Disorders	1.4%
561	Mental Retardation	1.4%
562	Muscle Weakness	1.4%
563	Depressed Level of Consciousness	1.4%
564	Mental deficiency	1.4%
565	Intellectual Disability	1.4%
566	Mitochondrial Encephalomyopathies	1.4%
567	Mobius Syndrome	1.4%
568	Bell Palsy	1.4%
569	Catatonia	1.4%
570	Herpes Zoster Oticus	1.4%
571	Familial Periodic Paralysis	1.4%
572	Meningitis, Cryptococcal	1.3%
573	Meningitis, Listeria	1.3%
574	Meningitis, Haemophilus	1.3%
575	Meningitis, Pneumococcal	1.3%
576	Frontotemporal dementia	1.3%
577	Transfusion-Related Acute Lung Injury	1.3%
578	Invasive Pulmonary Aspergillosis	1.3%
579	Cubital Tunnel Syndrome	1.3%
580	Pituitary Diseases	1.3%
581	Diffuse Axonal Injury	1.3%
582	Brain Stem Neoplasms	1.3%
583	Giant Cell Arteritis	1.3%
584	Temporal Arteritis	1.3%
585	Thoracic Outlet Syndrome	1.2%
586	Auditory Perceptual Disorders	1.2%
587	Carotid Artery Diseases	1.2%
588	Brain Ischemia	1.2%
589	Esotropia	1.2%
590	Exotropia	1.2%
591	Hypotension, Orthostatic	1.2%
592	Cerebrovascular accident	1.2%
593	Polymyositis	1.2%
594	Kluver-Bucy Syndrome	1.2%
595	Vasospasm, Intracranial	1.2%
596	Spinal Cord Ischemia	1.2%
597	Intracranial Arterial Diseases	1.2%
598	Post-Exercise Hypotension	1.2%
599	Trigeminal Nerve Disorder	1.2%
600	Dermal Sinus	1.2%
601	Dysgeusia	1.2%
602	Formication	1.2%
603	Hyperalgesia	1.2%
604	Hyperesthesia	1.2%
605	Hypesthesia	1.2%
606	Language Disorders	1.2%
607	Numbness	1.2%
608	Paresthesia	1.2%
609	Paraparesis, Spastic	1.2%
610	Spina Bifida Cystica	1.2%
611	Trismus	1.2%
612	Spina Bifida Occulta	1.2%
613	Epilepsia Partialis Continua	1.2%
614	Hypogeusia	1.2%
615	Meningeal Carcinomatosis	1.2%
616	Brown-Sequard Syndrome	1.2%
617	Lissencephaly	1.2%
618	Polymicrogyria	1.2%
619	Pachygyria	1.2%
620	Schizencephaly	1.2%
621	Lockjaw	1.2%
622	Allodynia	1.2%
623	Lead Poisoning, Nervous System, Childhood	1.2%
624	Lead Poisoning, Nervous System, Adult	1.2%
625	Periventricular Nodular Heterotopia	1.2%
626	Ageusia	1.2%
627	Tuberculosis, Central Nervous System	1.2%
628	Juvenile Myoclonic Epilepsy	1.2%
629	Myoclonic Epilepsies, Progressive	1.2%
630	Myalgia	1.2%
631	Neuronal Ceroid-Lipofuscinoses	1.2%
632	Pituitary Adenoma	1.1%
633	Pituitary Neoplasms	1.1%
634	Classical Lissencephalies and Subcortical Band Heterotopias	1.1%
635	Adrenoleukodystrophy	1.1%
636	Basal Ganglia Hemorrhage	1.1%
637	Pituitary Apoplexy	1.1%
638	Peritonsillar Abscess	1.1%
639	Brain Contusion	1.1%
640	Brain Infarction	1.1%
641	Polyradiculopathy	1.1%
642	Post-Traumatic Headache	1.1%
643	Tension Headache	1.1%
644	Epilepsy, Complex Partial	1.1%
645	Migraine Disorders	1.1%
646	Abdominal Migraine	1.1%
647	Status Migrainosus	1.1%
648	Cervicogenic Headache	1.1%
649	Subarachnoid Hemorrhage, Traumatic	1.1%
650	Carotid Artery, Internal, Dissection	1.1%
651	Aicardi's syndrome	1%
652	Cockayne Syndrome	1%
653	Alcohol Withdrawal Delirium	1%
654	Eye Injuries	1%
655	Subacute Sclerosing Panencephalitis	1%
656	Muscular Dystrophy	1%
657	Congenital nystagmus	1%
658	Orbital Myositis	1%
659	Diplopia	1%
660	Muscle Rigidity	1%
661	Muscle Spasticity	1%
662	Scotoma	1%
663	Photophobia	1%
664	Cogwheel Rigidity	1%
665	Hemifacial Spasm	1%
666	Amaurosis	1%
667	Blindness	1%
668	Nuchal Rigidity	1%
669	Reye Syndrome	1%
670	Neuroaspergillosis	1%
671	Pyomyositis	1%
672	Intracranial Embolism and Thrombosis	1%
673	Hepatic Encephalopathy	1%
674	Agnosia	1%
675	Apraxias	1%
676	Hallucinations	1%
677	Hemianopsia	1%
678	Hyperacusis	1%
679	Tinnitus	1%
680	Visual Agnosia	1%
681	Anosognosia	1%
682	Wernicke-Korsakoff Syndrome	1%
683	Phonophobia	1%
684	Hearing Loss	1%
685	Sarcopenia	1%
686	Choroid Plexus Papilloma	1%
687	Eosinophilic Granuloma	0.9%
688	Alexia	0.9%
689	Dyslexia	0.9%
690	Holoprosencephaly	0.9%
691	Hematoma, Subdural	0.9%
692	Hematoma, Epidural, Cranial	0.9%
693	Optic Atrophy, Hereditary, Leber	0.9%
694	MELAS Syndrome	0.9%
695	Pseudorabies	0.9%
696	Putaminal Hemorrhage	0.8%
697	Amnesia	0.8%
698	Delirium	0.8%
699	Empty Sella Syndrome	0.8%
700	Hyperpituitarism	0.8%
701	Hypopituitarism	0.8%
702	Dissociative Amnesia	0.8%
703	Color blindness	0.8%
704	Global Amnesia	0.8%
705	Hypophysitis	0.8%
706	Cri-du-Chat Syndrome	0.8%
707	Down Syndrome	0.8%
708	Brain Diseases, Metabolic, Inborn	0.8%
709	Trisomy 21	0.8%
710	POEMS Syndrome	0.8%
711	Meningioma	0.8%
712	Williams Syndrome	0.8%
713	Microcephaly	0.8%
714	Macrocephaly	0.8%
715	Neurosyphilis	0.8%
716	Hypokalemic periodic paralysis	0.8%
717	Kearns-Sayre syndrome	0.8%
718	Moyamoya Disease	0.8%
719	Cerebral Arterial Diseases	0.8%
720	Vertebrobasilar Insufficiency	0.8%
721	Anterior Spinal Artery Syndrome	0.8%
722	Basilar Artery Stenosis	0.8%
723	Vertebral Artery Stenosis	0.8%
724	Intracranial Hemorrhage, Hypertensive	0.8%
725	Transient Cerebral Ischemia	0.8%
726	Porencephaly	0.8%
727	Trigeminal Neuralgia	0.8%
728	Cluster Headache	0.8%
729	Migraine with Aura	0.8%
730	Familial Hemiplegic Migraine	0.8%
731	Chronic Paroxysmal Hemicrania	0.8%
732	SUNCT Syndrome	0.8%
733	Paroxysmal Hemicrania	0.8%
734	Agraphia	0.8%
735	Anomia	0.8%
736	Cluttering	0.8%
737	Language Development Disorders	0.8%
738	Speech Disorders	0.8%
739	Syncope	0.8%
740	Stupor	0.8%
741	Dysgraphia	0.8%
742	Presyncope	0.8%
743	Dyslalia	0.8%
744	Cerebral Infarction	0.8%
745	Neurofibrosarcoma	0.8%
746	Brain Stem Infarctions	0.8%
747	Infarction, Middle Cerebral Artery	0.8%
748	Infarction, Anterior Cerebral Artery	0.8%
749	Infarction, Posterior Cerebral Artery	0.8%
750	Prader-Willi Syndrome	0.7%
751	Wernicke Encephalopathy	0.7%
752	AIDS Dementia Complex	0.7%
753	Phantom pain	0.7%
754	Phantom Limb Pain	0.7%
755	Lyme Neuroborreliosis	0.7%
756	West Nile Fever	0.7%
757	Lateral Medullary Syndrome	0.7%
758	Toxoplasmosis, Congenital	0.7%
759	Eye Burns	0.7%
760	Malaria, Cerebral	0.6%
761	Carotid Stenosis	0.6%
762	Intracranial Aneurysm	0.6%
763	Welander Distal Myopathy	0.6%
764	Hematoma, Subdural, Intracranial	0.6%
765	Hematoma, Subdural, Chronic	0.6%
766	Hematoma, Subdural, Acute	0.6%
767	Neurocysticercosis	0.6%
768	Amaurosis Fugax	0.6%
769	Blindness, Cortical	0.6%
770	Dyscalculia	0.6%
771	Intracranial Arteriosclerosis	0.6%
772	Cerebral Atherosclerosis	0.6%
773	Rett Syndrome	0.6%
774	Subarachnoid Hemorrhage	0.6%
775	Cerebral Arteriosclerosis	0.6%
776	Cerebral Hemorrhage	0.6%
777	Cerebral Thrombosis	0.6%
778	Intracranial Embolism	0.6%
779	Intracranial Thrombosis	0.6%
780	Deafness	0.6%
781	Hearing Loss, Sudden	0.6%
782	Gerstmann Syndrome	0.6%
783	Hearing Loss, Bilateral	0.6%
784	Hearing Loss, High-Frequency	0.6%
785	Hearing Loss, Mixed Conductive-Sensorineural	0.6%
786	Prosopagnosia	0.6%
787	Apraxia, Ideomotor	0.6%
788	Charles Bonnet Syndrome	0.6%
789	Hearing Loss, Unilateral	0.6%
790	Complete Hearing Loss	0.6%
791	Alien Hand Syndrome	0.6%
792	Deaf Mutism	0.6%
793	Kernicterus	0.6%
794	Hyperprolactinemia	0.6%
795	Subclavian Steal Syndrome	0.6%
796	Pick Disease of the Brain	0.6%
797	Aphasia	0.6%
798	Articulation Disorders	0.6%
799	Echolalia	0.6%
800	Stuttering	0.6%
801	Dysphasia	0.6%
802	Dermatomyositis	0.6%
803	Corneal Scar	0.6%
804	Rubinstein-Taybi Syndrome	0.5%
805	Muscular Dystrophy, Duchenne	0.5%
806	Menkes Kinky Hair Syndrome	0.5%
807	Retrograde amnesia	0.5%
808	Amnesia, Anterograde	0.5%
809	Carotid Artery Thrombosis	0.5%
810	Waterhouse-Friderichsen Syndrome	0.5%
811	Dysarthria	0.5%
812	Mutism	0.5%
813	Selective Mutism	0.5%
814	Acromegaly	0.5%
815	Cerebral Amyloid Angiopathy	0.5%
816	Sinus Thrombosis, Intracranial	0.5%
817	Fragile X Syndrome	0.5%
818	Corneal Perforation	0.4%
819	Galactosemias	0.4%
820	Urea Cycle Disorders, Inborn	0.4%
821	Tyrosinemias	0.4%
822	Alexia, Pure	0.4%
823	Cavernous Sinus Thrombosis	0.4%
824	Sagittal Sinus Thrombosis	0.4%
825	Fabry Disease	0.4%
826	Homocystinuria	0.4%
827	Leigh Disease	0.4%
828	Prolactinoma	0.3%
829	Growth Hormone-Secreting Pituitary Adenoma	0.3%
830	Nelson Syndrome	0.3%
831	Mucopolysaccharidosis II	0.3%
832	Zellweger Syndrome	0.3%
833	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.3%
834	Glycogen storage disease type II	0.2%
835	Gaucher Disease	0.2%
836	Tay-Sachs Disease	0.2%
837	Niemann-Pick Disease, Type C	0.1%

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