MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Primary amyloidosis

(UMLS:C0268381)

Definition:: A nonproliferative disorder of the PLASMA CELL characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.
UMLS ID:: C0268381
MeSH ID:: D000075363

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.595.250

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.845.500.550

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.683.515.507|C20.683.780.565

Synonym(s)

Primary amyloidosis

AL Amyloidosis

AL amyloidosis

AMYLOIDOSIS, IDIOPATHIC

Amyloid light-chain amyloidosis

Amyloidosis, primary

Idiopathic amyloidosis

Primary Amyloidosis

Primary amyloidosis of light chain type

10.

al amyloidosis

11.

amyloidosis primary

12.

idiopathic amyloidosis

13.

primary amyloidosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Thalidomide	FAERS: 2	US FAERS
2	Clopidogrel	FAERS: 1	US FAERS
3	Itraconazole	FAERS: 1 Canada Vigilance: 2	Canada Vigilance US FAERS
4	Vortioxetine hydrobromide	FAERS: 1	US FAERS
5	Zoledronic Acid	FAERS: 1	US FAERS
6	ambrisentan	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Plasmacytoma	37.6%
2	Multiple Myeloma	35.6%
3	Leukemia, Plasma Cell	29.6%
4	Lymphoma	27.8%
5	Monoclonal Gammopathy of Undetermined Significance	26.3%
6	Sezary Syndrome	24.6%
7	Waldenstrom Macroglobulinemia	22.4%
8	Composite Lymphoma	22.2%
9	Tumor Lysis Syndrome	22.1%
10	Autoimmune Lymphoproliferative Syndrome	21.9%
11	Schnitzler Syndrome	19.7%
12	Hodgkin Disease	19.7%
13	Lymphoma, Non-Hodgkin	19.7%
14	Lymphangioleiomyomatosis	19.6%
15	Heavy Chain Disease	18.9%
16	Leukemia, T-Cell	18.2%
17	Leukemia, B-Cell	18.2%
18	Hypergammaglobulinemia	17.4%
19	Infectious Mononucleosis	16.5%
20	Cryoglobulinemia	16.5%
21	POEMS Syndrome	16.5%
22	Lymphoma, Follicular	15.8%
23	T-Cell Lymphoma	15.8%
24	Mantle cell lymphoma	15.8%
25	Amyloid Neuropathies, Familial	15.1%
26	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	15.1%
27	Leukemia, Large Granular Lymphocytic	15.1%
28	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	15.1%
29	Lymphomatoid Granulomatosis	14.8%
30	Neoplasms, Neuroepithelial	14.1%
31	Gliomatosis cerebri	14.1%
32	Cerebral Amyloid Angiopathy	13.9%
33	Lymphoma, T-Cell, Cutaneous	13.9%
34	Lymphoma, AIDS-Related	13.9%
35	Enteropathy-Associated T-Cell Lymphoma	13.9%
36	Primary Effusion Lymphoma	13.9%
37	Autoimmune Diseases	13.8%
38	Hypersensitivity	13.8%
39	Immunologic Deficiency Syndromes	13.8%
40	Immune reconstitution syndrome	13.8%
41	Immune Reconstitution Inflammatory Syndrome	13.8%
42	Medulloblastoma	13.5%
43	Neuroectodermal Tumors	13.3%
44	Mycosis Fungoides	12.9%
45	Lymphomatoid Papulosis	12.9%
46	Plasmablastic lymphoma	12.9%
47	melanoma	12.6%
48	leukemia	12.1%
49	Neoplasms, Germ Cell and Embryonal	12.1%
50	Neoplasms, Glandular and Epithelial	12.1%
51	Germ Cell Cancer	12.1%
52	Transfusion Reaction	11.6%
53	Hypotensive Transfusion Reaction	11.6%
54	Carcinosarcoma	11.5%
55	Hemangiosarcoma	11.5%
56	lymphangiosarcoma	11.5%
57	Wasting Syndrome	11.3%
58	Adenoma, Acidophil	11.2%
59	Ganglioneuroma	11.2%
60	Glioma	11.2%
61	Malignant Glioma	11.2%
62	Meningioma	10.9%
63	Burkitt Lymphoma	10.8%
64	Carcinoma 256, Walker	10.6%
65	Carcinoid Tumor	10.4%
66	Neurilemmoma	10.4%
67	Hutchinson's Melanotic Freckle	10.4%
68	Melanoma, Amelanotic	10.4%
69	Melanoma, Experimental	10.4%
70	Lymphoproliferative Disorders	10.2%
71	Acid-Base Imbalance	10.1%
72	Calcium Metabolism Disorders	10.1%
73	Iron Metabolism Disorders	10.1%
74	Phosphorus Metabolism Disorders	10.1%
75	Water-Electrolyte Imbalance	10.1%
76	Lipid Metabolism Disorders	10.1%
77	Mitochondrial Diseases	10.1%
78	Glucose Metabolism Disorders	10.1%
79	Histiocytic Disorders, Malignant	10.1%
80	Paraproteinemias	10.1%
81	Hypercalcemia	9.9%
82	Hypocalcemia	9.9%
83	Milk-Alkali Syndrome	9.9%
84	Primary amyloidosis	9.9%
85	Basal cell carcinoma	9.8%
86	Carcinoma, Papillary	9.8%
87	Squamous cell carcinoma	9.8%
88	Chondrosarcoma	9.8%
89	Craniopharyngioma	9.8%
90	Cystadenoma	9.8%
91	leiomyosarcoma	9.8%
92	liposarcoma	9.8%
93	Mesothelioma	9.8%
94	synovial sarcoma	9.8%
95	Neuroectodermal Tumor, Melanotic	9.8%
96	Angiomyolipoma	9.8%
97	Clear Cell Sarcoma of Soft Tissue	9.8%
98	Alveolar Soft Part Sarcoma	9.8%
99	Neuroendocrine Tumors	9.8%
100	Sarcoma, Myeloid	9.8%
101	Carcinoma, Basal Cell	9.8%
102	Astrocytoma	9.7%
103	Ependymoma	9.7%
104	oligodendroglioma	9.7%
105	Ganglioglioma	9.7%
106	gliosarcoma	9.7%
107	Anaplastic astrocytoma	9.7%
108	Anaplastic Oligodendroglioma	9.7%
109	Glomerulonephritis, Membranoproliferative	9.6%
110	Malignant Carcinoid Syndrome	9.4%
111	Glioblastoma	9%
112	Neuroblastoma	9%
113	Glioblastoma Multiforme	9%
114	Cystadenocarcinoma	9%
115	Fibrosarcoma	9%
116	Osteosarcoma	9%
117	Mucoepidermoid Carcinoma	9%
118	Pseudohypoparathyroidism	8.8%
119	Latent Autoimmune Diabetes in Adults	8.7%
120	Ganglioneuroblastoma	8.7%
121	Trophoblastic Neoplasms	8.6%
122	Adenofibroma	8.6%
123	Leukemia, Experimental	8.6%
124	Fibroadenoma	8.6%
125	Malignant Fibrous Histiocytoma	8.6%
126	Lipodystrophy	8.5%
127	Osteopenia	8.5%
128	Choriocarcinoma	8.4%
129	Carcinoma, Lobular	8.4%
130	Brain Diseases, Metabolic	8.4%
131	Carcinoma, Ehrlich Tumor	8.3%
132	Dermoid Cyst	8.3%
133	Carcinoma, Lewis Lung	8.3%
134	Bowen's Disease	8.2%
135	Paraganglioma	8.2%
136	Rhabdomyosarcoma	8.2%
137	Giant Cell Tumor of Bone	8.2%
138	Mastocytosis	8.1%
139	Retinoblastoma	8.1%
140	Immune Complex Diseases	8.1%
141	Antiphospholipid Syndrome	8.1%
142	Latex allergy	8.1%
143	Adenoma	7.9%
144	Ameloblastoma	7.9%
145	Angiokeratoma	7.9%
146	Carcinoma	7.9%
147	Chordoma	7.9%
148	Hemangioma	7.9%
149	hemangiopericytoma	7.9%
150	Lymphangioma	7.9%
151	Mesenchymoma	7.9%
152	Nevus	7.9%
153	Teratoma	7.9%
154	Hepatoblastoma	7.9%
155	Mixed Tumor, Mullerian	7.9%
156	Germinoma	7.9%
157	Teratocarcinoma	7.9%
158	Angiofibroma	7.9%
159	Sarcoma	7.9%
160	Epithelioma	7.9%
161	Rickets	7.9%
162	Endometrial Stromal Sarcoma	7.9%
163	Carcinoid Heart Disease	7.8%
164	Neurofibrosarcoma	7.8%
165	Dermatofibrosarcoma	7.7%
166	Dermatofibrosarcoma Protuberans	7.7%
167	Leukemia, Radiation-Induced	7.6%
168	Leigh Disease	7.5%
169	Brain Diseases, Metabolic, Inborn	7.4%
170	Thrombocytopenic purpura	7.4%
171	Mastocytosis, Systemic	7.4%
172	Pheochromocytoma	7.3%
173	Alveolar rhabdomyosarcoma	7.3%
174	HIV Wasting Syndrome	7.3%
175	Autoimmune thrombocytopenia	7.2%
176	Immune thrombocytopenic purpura	7.2%
177	Leukemia L1210	7.1%
178	Leukemia P388	7.1%
179	Acanthoma	7.1%
180	Sarcoma, Experimental	7.1%
181	Thymoma	7.1%
182	Kernicterus	7%
183	Environmental Illness	6.9%
184	Hamartoma	6.9%
185	Neoplasms, Hormone-Dependent	6.9%
186	Neoplasms, Multiple Primary	6.9%
187	Paraneoplastic Syndromes	6.9%
188	Precancerous Conditions	6.9%
189	Neoplasms, Second Primary	6.9%
190	Lupus Erythematosus, Systemic	6.8%
191	Overlap syndrome	6.8%
192	Addison Disease	6.7%
193	Pemphigus	6.7%
194	Autoimmune thyroiditis	6.7%
195	Primary Adrenal Insufficiency	6.7%
196	Lymphopenia	6.7%
197	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	6.7%
198	Autoimmune hepatitis	6.7%
199	Hyperhomocysteinemia	6.6%
200	Carbamoyl-Phosphate Synthase I Deficiency Disease	6.6%
201	Malignant histiocytosis	6.6%
202	Histiocytic sarcoma	6.6%
203	HIV-Associated Lipodystrophy Syndrome	6.5%
204	Acoustic Neuroma	6.5%
205	Ataxia Telangiectasia	6.4%
206	Sarcoma 180	6.3%
207	Nutrition Disorders	6.2%
208	Lactose Intolerance	6.1%
209	Multiple Endocrine Neoplasia	6%
210	Carcinoma, Pancreatic Ductal	6%
211	Acidosis	6%
212	Alkalosis	6%
213	Calcinosis	6%
214	Hyperglycemia	6%
215	Hyperinsulinism	6%
216	Hyperkalemia	6%
217	Hypernatremia	6%
218	Hypoglycemia	6%
219	Hypokalemia	6%
220	Hyponatremia	6%
221	Xanthomatosis	6%
222	Hypophosphatemia	6%
223	Metabolic acidosis	6%
224	Dyslipidemias	6%
225	Iron Overload	6%
226	Xanthoma	6%
227	Basal Cell Nevus Syndrome	5.9%
228	Optic Nerve Glioma	5.9%
229	Adenocarcinoma	5.9%
230	Carcinoma in Situ	5.9%
231	Carcinoma, Transitional Cell	5.9%
232	Phyllodes Tumor	5.9%
233	Dysgerminoma	5.9%
234	Hemangioendothelioma	5.9%
235	Lipoma	5.9%
236	Myoma	5.9%
237	Myxoma	5.9%
238	Neuroma	5.9%
239	Papilloma	5.9%
240	Pseudomyxoma Peritonei	5.9%
241	Seminoma	5.9%
242	Papillomatosis	5.9%
243	Angiolipoma	5.9%
244	Myelolipoma	5.9%
245	Neoplasms, Bone Tissue	5.9%
246	Neoplasms, Fibrous Tissue	5.9%
247	Smooth Muscle Tumor	5.9%
248	Adenomatosis, Pulmonary	5.9%
249	Adenomatous Polyps	5.9%
250	Carcinoma, Large Cell	5.9%
251	Carcinoma, Small Cell	5.9%
252	Desmoplastic Small Round Cell Tumor	5.9%
253	Chondroma	5.9%
254	Enchondroma	5.9%
255	Asthma, Aspirin-Induced	5.9%
256	Smith-Lemli-Opitz Syndrome	5.9%
257	Galactosemias	5.9%
258	Urea Cycle Disorders, Inborn	5.9%
259	Tyrosinemias	5.9%
260	Cyst	5.8%
261	Neoplastic Processes	5.8%
262	Neoplastic Syndromes, Hereditary	5.8%
263	Pregnancy Complications, Neoplastic	5.8%
264	Agammaglobulinemia	5.7%
265	Dermatitis Herpetiformis	5.7%
266	Kounis Syndrome	5.7%
267	Serum Sickness	5.7%
268	HIV Infections	5.7%
269	Neoplasms, Experimental	5.7%
270	Transfusion-Related Acute Lung Injury	5.7%
271	Familial Hypophosphatemic Rickets	5.6%
272	Nephroblastoma	5.6%
273	Hypolipoproteinemias	5.6%
274	Hyperlipoproteinemia Type IV	5.5%
275	Hyperlipoproteinemia Type V	5.5%
276	Mitochondrial Encephalomyopathies	5.5%
277	Vipoma	5.4%
278	Osteomalacia	5.3%
279	Hyperphosphaturia	5.3%
280	anaphylaxis	5.3%
281	Food Allergy	5.3%
282	Anaphylactic shock	5.3%
283	Amyotrophic Lateral Sclerosis	5.1%
284	Diabetes Mellitus	5.1%
285	Rheumatoid Arthritis	5.1%
286	Juvenile arthritis	5.1%
287	Dehydration	5%
288	Lipomatosis	5%
289	Water Intoxication	5%
290	Werner Syndrome	5%
291	Graves Disease	5%
292	Congenital Hyperinsulinism	5%
293	Lambert-Eaton Myasthenic Syndrome	5%
294	Achlorhydria	5%
295	Amino Acid Metabolism, Inborn Errors	5%
296	Bloom Syndrome	5%
297	Carbohydrate Metabolism, Inborn Errors	5%
298	Metal Metabolism, Inborn Errors	5%
299	Osteoporosis	5%
300	Progeria	5%
301	Lysosomal Storage Diseases	5%
302	Bone Demineralization, Pathologic	5%
303	Cytochrome-c Oxidase Deficiency	5%
304	Peroxisomal Disorders	5%
305	Post-Traumatic Osteoporosis	5%
306	Anti-Glomerular Basement Membrane Disease	5%
307	Celiac Disease	4.9%
308	Sprue, Tropical	4.9%
309	Steatorrhea	4.9%
310	Sprue	4.9%
311	Hepatocellular Adenoma	4.9%
312	Adenoid Cystic Carcinoma	4.9%
313	Diabetic Ketoacidosis	4.9%
314	fibroma	4.9%
315	Fibromatosis	4.9%
316	Leukemia, Myelomonocytic, Chronic	4.9%
317	Osteoblastoma	4.9%
318	Osteoma	4.9%
319	Rhabdomyoma	4.9%
320	Chondromatosis	4.9%
321	Adenocarcinoma, Clear Cell	4.9%
322	Cholangiocarcinoma	4.9%
323	Cervical Intraepithelial Neoplasia	4.9%
324	Hemangioblastoma	4.9%
325	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4.9%
326	Lymphoma, Extranodal NK-T-Cell	4.9%
327	Homocystinuria	4.9%
328	Neoplasms, Radiation-Induced	4.9%
329	Hyperlipidemia, Familial Combined	4.9%
330	Hydatidiform Mole	4.9%
331	Paraneoplastic Encephalomyelitis	4.8%
332	Glycogen storage disease type II	4.8%
333	Gaucher Disease	4.8%
334	Mammary Neoplasms, Experimental	4.8%
335	Mesoblastic Nephroma	4.7%
336	Tuberous Sclerosis	4.7%
337	Respiratory Hypersensitivity	4.6%
338	Hyperlipoproteinemia Type III	4.5%
339	Sick Building Syndrome	4.5%
340	Multiple Chemical Sensitivity	4.5%
341	Urticaria	4.4%
342	Vasculitis, Leukocytoclastic, Cutaneous	4.4%
343	Fibromatosis, Aggressive	4.4%
344	Fibromatosis, Abdominal	4.4%
345	Klatskin Tumor	4.4%
346	HTLV-I Infections	4.4%
347	Job Syndrome	4.4%
348	Prolactinoma	4.4%
349	Growth Hormone-Secreting Pituitary Adenoma	4.4%
350	Adrenoleukodystrophy	4.4%
351	Renal tubular acidosis	4.3%
352	Mitochondrial Myopathies	4.3%
353	Sturge-Weber Syndrome	4.3%
354	Myelinolysis, Central Pontine	4.3%
355	Frontotemporal dementia	4.3%
356	Glycosuria	4.2%
357	Reye Syndrome	4.2%
358	Gastrointestinal Stromal Tumors	4.2%
359	Hemangioma, Cavernous	4.2%
360	Hepatic Encephalopathy	4.2%
361	Zellweger Syndrome	4.2%
362	neurofibroma	4.2%
363	Xeroderma Pigmentosum	4.2%
364	Menkes Kinky Hair Syndrome	4.2%
365	Hypoalphalipoproteinemias	4.2%
366	Mastocytoma	4.1%
367	MELAS Syndrome	4.1%
368	Leukemia, Myeloid, Chronic-Phase	4.1%
369	insulinoma	4.1%
370	Multiple Endocrine Neoplasia Type 1	4%
371	Abdominal Neoplasms	4%
372	Erythroplasia	4%
373	Follicular cyst	4%
374	Head and Neck Neoplasms	4%
375	Mucocele	4%
376	Pilonidal Cyst	4%
377	Soft Tissue Neoplasms	4%
378	Thoracic Neoplasms	4%
379	Thyroglossal Cyst	4%
380	Synovial Cyst	4%
381	Aberrant Crypt Foci	4%
382	Tay-Sachs Disease	3.9%
383	Acidosis, Lactic	3.9%
384	Calciphylaxis	3.9%
385	Hemosiderosis	3.9%
386	Ketosis	3.9%
387	Milk Allergy	3.9%
388	Ketonuria	3.9%
389	Ketoacidosis	3.9%
390	Ketonemia	3.9%
391	Vascular calcification	3.9%
392	Wheat Hypersensitivity	3.9%
393	Adenomatous Polyposis Coli	3.9%
394	Hepatolenticular Degeneration	3.9%
395	Myasthenia Gravis, Autoimmune, Experimental	3.9%
396	Niemann-Pick Disease, Type C	3.9%
397	Fabry Disease	3.9%
398	granulosa cell tumor	3.9%
399	Carcinoma, Ovarian Epithelial	3.9%
400	Refsum Disease	3.9%
401	Renal Osteodystrophy	3.9%
402	Renal rickets	3.9%
403	Myasthenia Gravis	3.8%
404	Uveomeningoencephalitic Syndrome	3.8%
405	Neuronal Ceroid-Lipofuscinoses	3.8%
406	Gastrinoma	3.8%
407	Glucagonoma	3.8%
408	Drug Eruptions	3.8%
409	Chronic granulomatous disease	3.8%
410	Porphyrias, Hepatic	3.8%
411	Granulomatosis with polyangiitis	3.8%
412	Dermatitis, Allergic Contact	3.8%
413	HIV Seropositivity	3.7%
414	Necrobiosis Lipoidica Diabeticorum	3.7%
415	Wernicke Encephalopathy	3.7%
416	Fanconi Anemia	3.7%
417	Nesidioblastosis	3.7%
418	Adrenocortical carcinoma	3.6%
419	Hydrops Fetalis	3.6%
420	Leydig Cell Tumor	3.6%
421	Myelitis, Transverse	3.6%
422	Glycosuria, Renal	3.5%
423	Digestive System Neoplasms	3.5%
424	Endocrine Gland Neoplasms	3.5%
425	Eye Neoplasms	3.5%
426	Nervous System Neoplasms	3.5%
427	Bone neoplasms	3.4%
428	Leukoplakia	3.4%
429	Lymphocele	3.4%
430	Pancreatic Cyst	3.4%
431	Skin Neoplasms	3.4%
432	Hematologic Neoplasms	3.4%
433	Parathyroid Neoplasms	3.4%
434	Peritoneal Neoplasms	3.4%
435	Thyroid Neoplasm	3.4%
436	Stiff-Person Syndrome	3.4%
437	Thyroid carcinoma	3.4%
438	Polyradiculoneuropathy	3.4%
439	Polyradiculoneuritis	3.4%
440	Child Nutrition Disorders	3.4%
441	Hypervitaminosis A	3.4%
442	Infant Nutrition Disorders	3.4%
443	Malnutrition	3.4%
444	Barrett Esophagus	3.4%
445	Breast Cyst	3.4%
446	Actinic keratosis	3.4%
447	Mediastinal Cyst	3.4%
448	Neoplasm Invasiveness	3.4%
449	Neoplasm Metastasis	3.4%
450	Neoplasm Recurrence, Local	3.4%
451	Parovarian Cyst	3.4%
452	Pericardial Cyst	3.4%
453	Splenic Neoplasms	3.4%
454	Thymic Cyst	3.4%
455	Carcinogenesis	3.4%
456	Myxoid cyst	3.4%
457	Metastasis	3.4%
458	Liver Neoplasms, Experimental	3.3%
459	Nasopharyngeal carcinoma	3.3%
460	Acquired Immunodeficiency Syndrome	3.3%
461	AIDS related complex	3.3%
462	Acidosis, Respiratory	3.3%
463	Adiposis Dolorosa	3.3%
464	Alkalosis, Respiratory	3.3%
465	Felty Syndrome	3.3%
466	Alkaptonuria	3.3%
467	Glycogen Storage Disease	3.3%
468	Hypophosphatasia	3.3%
469	Insulin Resistance	3.3%
470	Osteoporosis, Postmenopausal	3.3%
471	Propionic acidemia	3.3%
472	Dihydropyrimidine Dehydrogenase Deficiency	3.3%
473	Cystinosis	3.3%
474	Lupus Nephritis	3.3%
475	Friedreich Ataxia	3.3%
476	Mucopolysaccharidosis III	3.2%
477	Renal Cell Carcinoma	3.2%
478	Papillary Renal Cell Carcinoma	3.2%
479	Dupuytren Contracture	3.2%
480	Urticaria Pigmentosa	3.2%
481	Carcinoma, Endometrioid	3.1%
482	Kearns-Sayre syndrome	3.1%
483	Denys-Drash Syndrome	3.1%
484	Lupus Vasculitis, Central Nervous System	3%
485	Pancreatic Neoplasm	3%
486	Neuromyelitis Optica	3%
487	Leukoencephalitis, Acute Hemorrhagic	3%
488	Cockayne Syndrome	3%
489	AIDS-Related Opportunistic Infections	3%
490	Vasculitis, Central Nervous System	3%
491	Dermatitis, Atopic	3%
492	Hypercholesterolemia	3%
493	Hyperlipoproteinemias	3%
494	Hypertriglyceridemia	3%
495	Tracheal Neoplasms	2.9%
496	Rheumatoid Vasculitis	2.9%
497	AIDS Dementia Complex	2.9%
498	AIDS-Associated Nephropathy	2.9%
499	Leukoplakia, Oral	2.9%
500	Gestational Diabetes	2.9%
501	Paraneoplastic Cerebellar Degeneration	2.9%
502	Diabetes Mellitus, Experimental	2.9%
503	Corpus Luteum Cyst	2.9%
504	Ovarian Cysts	2.9%
505	Angioedema	2.8%
506	Multiple Sclerosis	2.8%
507	Nephrocalcinosis	2.8%
508	Tetany	2.8%
509	Acute Generalized Exanthematous Pustulosis	2.8%
510	Optic Atrophy, Hereditary, Leber	2.7%
511	Retroperitoneal Neoplasms	2.6%
512	Sjogren-Larsson Syndrome	2.6%
513	Wiskott-Aldrich Syndrome	2.6%
514	Sicca Syndrome	2.6%
515	Sjogren's Syndrome	2.6%
516	Esophageal Neoplasms	2.6%
517	Limbic Encephalitis	2.6%
518	Choledochal Cyst	2.5%
519	Asthma	2.5%
520	Familial Periodic Paralysis	2.5%
521	Peutz-Jeghers Syndrome	2.5%
522	Thyroid Nodule	2.5%
523	Encephalomyelitis, Acute Disseminated	2.5%
524	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.5%
525	Erythema Nodosum	2.5%
526	Neuritis, Autoimmune, Experimental	2.5%
527	Variegate Porphyria	2.5%
528	Acute intermittent porphyria	2.5%
529	Porphyria Cutanea Tarda	2.5%
530	Dermatitis, Photoallergic	2.4%
531	Glycogen Storage Disease Type I	2.4%
532	Glycogen Storage Disease Type V	2.4%
533	Renal Aminoacidurias	2.4%
534	Fanconi Syndrome	2.4%
535	Pseudohypoaldosteronism	2.4%
536	Liddle Syndrome	2.4%
537	Canavan Disease	2.4%
538	Alexander Disease	2.4%
539	Mucopolysaccharidosis II	2.4%
540	Asthma, Exercise-Induced	2.4%
541	Status Asthmaticus	2.4%
542	Testicular Neoplasms	2.3%
543	Multiple Sclerosis, Chronic Progressive	2.3%
544	Multiple Sclerosis, Relapsing-Remitting	2.3%
545	Mouth Neoplasms	2.2%
546	Central Nervous System Neoplasms	2.2%
547	Vascular Neoplasms	2.2%
548	Thymus Neoplasms	2.2%
549	Gout	2.2%
550	Genital Neoplasms, Female	2.2%
551	Pancreatic Pseudocyst	2.2%
552	Aspergillosis, Allergic Bronchopulmonary	2.2%
553	Lymphatic Metastasis	2.2%
554	Neoplasms, Unknown Primary	2.2%
555	Leukemic Infiltration	2.2%
556	Breast Neoplasms, Male	2.2%
557	Neoplasm Micrometastasis	2.2%
558	Triple Negative Breast Neoplasms	2.2%
559	Guillain-Barre Syndrome	2.2%
560	Antley-Bixler Syndrome Phenotype	2.2%
561	Opsoclonus-Myoclonus Syndrome	2.1%
562	Asthma, Occupational	2.1%
563	Hereditary Angioedema Type III	2.1%
564	Hereditary Angioedema Types I and II	2.1%
565	Farmer's Lung	2.1%
566	Angioedemas, Hereditary	2.1%
567	Hay fever	2%
568	Rhinitis, Allergic, Perennial	2%
569	Deficiency Diseases	2%
570	Starvation	2%
571	Refeeding Syndrome	2%
572	Toxic Epidermal Necrolysis	2%
573	Stevens-Johnson Syndrome	2%
574	CREST Syndrome	2%
575	Adrenal Gland Neoplasms	1.9%
576	Gastrointestinal Neoplasms	1.9%
577	Genital Neoplasms, Male	1.9%
578	Liver neoplasms	1.9%
579	Uveal Neoplasms	1.9%
580	Urologic Neoplasms	1.9%
581	Sebaceous Gland Neoplasms	1.9%
582	Spinal Neoplasms	1.9%
583	Bone Marrow Neoplasms	1.9%
584	Polycystic Ovary Syndrome	1.9%
585	Nose Neoplasms	1.8%
586	Hypokalemic periodic paralysis	1.8%
587	Cystinuria	1.8%
588	Albinism	1.8%
589	Palatal Neoplasms	1.8%
590	Giant Cell Arteritis	1.8%
591	Temporal Arteritis	1.8%
592	Pituitary Adenoma	1.7%
593	Pituitary Neoplasms	1.7%
594	Meningeal Neoplasms	1.6%
595	Arthritis, Gouty	1.6%
596	Ichthyosis, X-Linked	1.5%
597	ovarian neoplasm	1.5%
598	Ear Neoplasms	1.4%
599	Eyelid Neoplasms	1.4%
600	Lung Neoplasms	1.4%
601	Pleural Neoplasms	1.4%
602	Cell Transformation, Viral	1.4%
603	Brain Neoplasms	1.4%
604	Salivary Gland Neoplasms	1.4%
605	Spinal Cord Neoplasms	1.4%
606	Tongue Neoplasms	1.4%
607	Uterine Neoplasms	1.4%
608	Vaginal Neoplasms	1.4%
609	Vulvar Neoplasms	1.4%
610	Uterine Cancer	1.4%
611	Fallopian Tube Neoplasms	1.4%
612	Miller Fisher Syndrome	1.4%
613	Meningeal Carcinomatosis	1.4%
614	Kwashiorkor	1.3%
615	Magnesium Deficiency	1.3%
616	Potassium Deficiency	1.3%
617	Protein Deficiency	1.3%
618	Avitaminosis	1.3%
619	Pharyngeal Neoplasms	1.3%
620	Central Nervous System Cysts	1.3%
621	Bile Duct Neoplasms	1.2%
622	gallbladder neoplasm	1.2%
623	Intestinal Neoplasms	1.2%
624	Penile Neoplasms	1.2%
625	Prostatic Neoplasms	1.2%
626	Stomach Neoplasms	1.2%
627	Polycythemia Vera	1.2%
628	Obesity	1.2%
629	Zollinger-Ellison syndrome	1.2%
630	Bronchial Neoplasms	1.2%
631	Multiple Pulmonary Nodules	1.2%
632	Supratentorial Neoplasms	1.2%
633	Endometrial Neoplasms	1.2%
634	Laryngeal neoplasm	1.1%
635	Bladder Neoplasm	1.1%
636	Kidney Neoplasm	1.1%
637	Ureteral Neoplasms	1.1%
638	Urethral Neoplasms	1.1%
639	Brain Stem Neoplasms	1%
640	Hypopharyngeal Neoplasms	1%
641	Pleural Effusion, Malignant	1%
642	Hypopharyngeal Cancer	1%
643	Parotid Neoplasms	1%
644	Prostatic Neoplasms, Castration-Resistant	1%
645	Nelson Syndrome	1%
646	Ascorbic Acid Deficiency	1%
647	Vitamin A Deficiency	1%
648	Vitamin D Deficiency	1%
649	Vitamin E Deficiency	1%
650	Marasmus	1%
651	Choroid Plexus Papilloma	1%
652	Obesity, Abdominal	0.9%
653	Tonsillar Neoplasms	0.9%
654	Cerebellar Neoplasms	0.9%
655	Cecal Neoplasms	0.9%
656	Duodenal Neoplasms	0.9%
657	Nasopharyngeal Neoplasms	0.8%
658	Folic Acid Deficiency	0.8%
659	Pellagra	0.8%
660	Thiamine Deficiency	0.8%
661	Vitamin B 12 Deficiency	0.8%
662	Vitamin B 6 Deficiency	0.8%
663	Pyridoxine Deficiency	0.8%
664	Colorectal Neoplasms	0.8%
665	Radicular Cyst	0.8%
666	Pediatric Obesity	0.8%
667	Appendiceal Neoplasms	0.8%
668	Colonic Neoplasms	0.8%
669	Rectal Neoplasms	0.8%
670	Paranasal Sinus Neoplasms	0.8%
671	Beriberi	0.7%
672	Prader-Willi Syndrome	0.7%
673	Vitamin K Deficiency	0.7%
674	Anus Neoplasms	0.7%
675	Sigmoid Neoplasms	0.7%
676	Maxillary Sinus Neoplasms	0.7%
677	Anemia, Pernicious	0.6%
678	Scurvy	0.6%
679	Subacute Combined Degeneration	0.4%

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