MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteosclerosis

(UMLS:C0029464)

Definition:: An abnormal hardening or increased density of bone tissue.
UMLS ID:: C0029464
MeSH ID:: D010026

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.708.702

Synonym(s)

Osteosclerosis

Bone density increased

Increased bone density

Increased bone mineral density

OSTEOSCLEROSIS

Osteosclerosis of bones

osteosclerosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Zoledronic Acid	FAERS: 68 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
2	Alendronate	FAERS: 50		US FAERS
3	Alendronate	FAERS: 7		US FAERS
4	Risedronic Acid	FAERS: 7		US FAERS
5	Pamidronate	FAERS: 6		US FAERS
6	Medroxyprogesterone Acetate	FAERS: 5		US FAERS
7	Sitagliptin Phosphate	FAERS: 4		US FAERS
8	Bortezomib	FAERS: 3		US FAERS
9	adefovir dipivoxil	FAERS: 3		US FAERS
10	Acitretin	FAERS: 2		US FAERS
11	HhAntag691	FAERS: 2		US FAERS
12	Octreotide	FAERS: 2		US FAERS
13	Ruxolitinib phosphate	FAERS: 2		US FAERS
14	Tenofovir	FAERS: 2		US FAERS
15	Vemurafenib	FAERS: 2		US FAERS
16	Voriconazole	FAERS: 2		US FAERS
17	Aspirin	FAERS: 1		US FAERS
18	Cinacalcet	FAERS: 1		US FAERS
19	Cysteamine	FAERS: 1		US FAERS
20	Dimethyl Fumarate	FAERS: 1		US FAERS
21	Erlotinib Hydrochloride	FAERS: 1		US FAERS
22	Fulvestrant	FAERS: 1		OFFSIDES US FAERS
23	Imatinib Mesylate	FAERS: 1		US FAERS
24	Imatinib Mesylate	FAERS: 1		US FAERS
25	Isotretinoin	FAERS: 1		US FAERS
26	LDE225	FAERS: 1		US FAERS
27	Letrozole	FAERS: 1		OFFSIDES US FAERS
28	Marcaine hydrochloride w/epinephrine	FAERS: 1		US FAERS
29	Methylprednisolone Acetate	FAERS: 1		US FAERS
30	NuvaRing	FAERS: 1		US FAERS
31	Raloxifene Hydrochloride	FAERS: 1		US FAERS
32	Sodium risedronate hydrate	FAERS: 1		US FAERS
33	carfilzomib	FAERS: 1		US FAERS
34	ceritinib	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
35	palbociclib	FAERS: 1		US FAERS
36	salmon calcitonin	FAERS: 1		US FAERS
37	Alprazolam			OFFSIDES
38	Amifostine			OFFSIDES
39	Amiloride			OFFSIDES
40	Amlodipine			OFFSIDES
41	Amoxicillin			OFFSIDES
42	Ampicillin			OFFSIDES
43	Anastrozole			OFFSIDES
44	Aprepitant			OFFSIDES
45	Azithromycin			OFFSIDES
46	Benztropine			OFFSIDES
47	Bisacodyl			OFFSIDES
48	Bumetanide			OFFSIDES
49	Bupropion			OFFSIDES
50	Busulfan			OFFSIDES
51	Cabergoline			OFFSIDES
52	Calcium Carbonate			OFFSIDES
53	Calcium Citrate			OFFSIDES
54	Capecitabine			OFFSIDES
55	Carboplatin			OFFSIDES
56	Cefadroxil			OFFSIDES
57	Cefepime			OFFSIDES
58	Celecoxib			OFFSIDES
59	Cephalexin			OFFSIDES
60	Chlorhexidine			OFFSIDES
61	Cisapride			OFFSIDES
62	Clindamycin			OFFSIDES
63	Clobetasol			OFFSIDES
64	Clobetasol			OFFSIDES
65	Clopidogrel			OFFSIDES
66	Clotrimazole			OFFSIDES
67	Cyclosporine			OFFSIDES
68	Dermazin			OFFSIDES
69	Dexamethasone			OFFSIDES
70	Diane			OFFSIDES
71	Dicloxacillin			OFFSIDES
72	Diltiazem			OFFSIDES
73	Dioctyl Sulfosuccinic Acid			OFFSIDES
74	Diphenoxylate			OFFSIDES
75	Docetaxel			OFFSIDES
76	Doxazosin			OFFSIDES
77	Doxorubicin			OFFSIDES
78	Doxycycline			OFFSIDES
79	Duloxetine Hydrochloride			OFFSIDES
80	Dutasteride			OFFSIDES
81	Ephedrine			OFFSIDES
82	Ertapenem			OFFSIDES
83	Erythromycin			OFFSIDES
84	Estrogens, Conjugated (USP)			OFFSIDES
85	Etodolac			OFFSIDES
86	Famotidine			OFFSIDES
87	Felbinac			OFFSIDES
88	Fentanyl			OFFSIDES
89	Fludrocortisone			OFFSIDES
90	Fluocinolone Acetonide			OFFSIDES
91	Fluorouracil			OFFSIDES
92	Flurazepam			OFFSIDES
93	Fosinopril			OFFSIDES
94	Gabapentin			OFFSIDES
95	Gatifloxacin			OFFSIDES
96	Glyburide			OFFSIDES
97	Goserelin			OFFSIDES
98	Hydrochlorothiazide			OFFSIDES
99	Hydrocortisone			OFFSIDES
100	Hydromorphone			OFFSIDES
101	Ibuprofen			OFFSIDES
102	Indapamide			OFFSIDES
103	Isradipine			OFFSIDES
104	Itraconazole			OFFSIDES
105	Ketoconazole			OFFSIDES
106	Ketorolac			OFFSIDES
107	Ketorolac Tromethamine			OFFSIDES
108	Linezolid			OFFSIDES
109	Lorazepam			OFFSIDES
110	Lubiprostone			OFFSIDES
111	Lycopene			OFFSIDES
112	Megestrol Acetate			OFFSIDES
113	Melphalan		3039073	CTD OFFSIDES
114	Memantine			OFFSIDES
115	Methocarbamol			OFFSIDES
116	Methotrexate			OFFSIDES
117	Methylphenidate			OFFSIDES
118	Methylprednisolone Hemisuccinate			OFFSIDES
119	Metolazone			OFFSIDES
120	Metronidazole			OFFSIDES
121	Midodrine			OFFSIDES
122	Mitoxantrone			OFFSIDES
123	Moxifloxacin			OFFSIDES
124	Nabumetone			OFFSIDES
125	Nalbuphine			OFFSIDES
126	Naloxone			OFFSIDES
127	Niacin			OFFSIDES
128	Nitrofurantoin			OFFSIDES
129	Nizatidine			OFFSIDES
130	Nortriptyline			OFFSIDES
131	Octreotide			OFFSIDES
132	Paclitaxel			OFFSIDES
133	Palonosetron			OFFSIDES
134	Pamidronate			OFFSIDES
135	Penicillin V			OFFSIDES
136	Pentoxifylline			OFFSIDES
137	Perphenazine			OFFSIDES
138	Phentermine			OFFSIDES
139	Phosphates			OFFSIDES
140	Piroxicam			OFFSIDES
141	Potassium			OFFSIDES
142	Prednisone		3039073	CTD
143	Primidone			OFFSIDES
144	Prochlorperazine			OFFSIDES
145	Promethazine			OFFSIDES
146	Propafenone			OFFSIDES
147	Pyridoxine			OFFSIDES
148	Rifaximin			OFFSIDES
149	Scopolamine			OFFSIDES
150	Selenium			OFFSIDES
151	Sertraline			OFFSIDES
152	Sevelamer			OFFSIDES
153	Sevelamer			OFFSIDES
154	Sulbactam			OFFSIDES
155	Sulindac			OFFSIDES
156	Sumatriptan			OFFSIDES
157	Tamoxifen			OFFSIDES
158	Tazobactam			OFFSIDES
159	Thalidomide			OFFSIDES
160	Thiamine			OFFSIDES
161	Thiethylperazine			OFFSIDES
162	Thiotepa			OFFSIDES
163	Tramadol			OFFSIDES
164	Tretinoin			OFFSIDES
165	Triamcinolone			OFFSIDES
166	Triamterene			OFFSIDES
167	Vancomycin			OFFSIDES
168	Varenicline			OFFSIDES
169	Venlafaxine Hydrochloride			SIDER
170	Vinorelbine			OFFSIDES
171	Vorinostat			OFFSIDES
172	Warfarin			OFFSIDES
173	alfuzosin			OFFSIDES
174	azelastine			OFFSIDES
175	benzonatate			OFFSIDES
176	betamethasone-17,21-dipropionate			OFFSIDES
177	bicalutamide			OFFSIDES
178	brinzolamide			OFFSIDES
179	carbidopa, levodopa drug combination			OFFSIDES
180	cevimeline			OFFSIDES
181	chlorhexidine gluconate			OFFSIDES
182	cyclobenzaprine			OFFSIDES
183	dolasetron			OFFSIDES
184	exemestane			OFFSIDES
185	fexofenadine			OFFSIDES
186	hydrocodone tartrate, ibuprofen drug combination			OFFSIDES
187	magnesium citrate			OFFSIDES
188	prednisolone acetate			OFFSIDES
189	ramelteon			OFFSIDES
190	reviparin			OFFSIDES
191	rizatriptan			OFFSIDES
192	rizatriptan			OFFSIDES
193	ropinirole			OFFSIDES
194	samarium Sm-153 lexidronam			OFFSIDES
195	selenium disulfide			OFFSIDES
196	sennoside A&B			OFFSIDES
197	terconazole			OFFSIDES
198	valdecoxib			OFFSIDES
199	voglibose			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Chondrodysplasia Punctata	48.4%
2	Enchondromatosis	48.4%
3	Kashin-Beck Disease	48.4%
4	Dysostoses	34.4%
5	Hyperostosis	25.4%
6	Osteitis	25.4%
7	Osteitis Deformans	25.4%
8	Osteochondrosis	25.4%
9	Spinal Diseases	25.4%
10	Osteogenesis Imperfecta	25%
11	Gigantism	24.8%
12	Osteoarthropathy, Secondary Hypertrophic	23%
13	Pectus excavatum	21.8%
14	Platybasia	21.7%
15	Dwarfism	18.6%
16	Bone Diseases, Endocrine	18.1%
17	Pectus carinatum	17.5%
18	Bone Diseases, Infectious	17.2%
19	Bone neoplasms	17.2%
20	Osteopenia	17.2%
21	Osteochondritis	17.1%
22	Bone Resorption	16.9%
23	Aseptic Necrosis of Bone	16.9%
24	Fasciitis	16.4%
25	Foot Deformities	16.4%
26	Arthropathy	16.4%
27	Klippel-Feil Syndrome	15.8%
28	Synostosis	15.8%
29	Spinal Neoplasms	14.9%
30	Spondylitis	14.9%
31	Ainhum	14.8%
32	Spinal Stenosis	14.8%
33	Spondylosis	14.8%
34	Intervertebral Disc Degeneration	14.8%
35	Craniofacial Dysostosis	13.8%
36	Congenital Hypothyroidism	12.8%
37	Contracture	11.5%
38	Fasciitis, Plantar	11.5%
39	Jaw Diseases	11.4%
40	Cartilage Diseases	10.8%
41	Foot Diseases	10.8%
42	Myopathy	10.8%
43	Rheumatism	10.8%
44	Chondromalacia	10.8%
45	Arthrogryposis	10.3%
46	Osteomyelitis	9.9%
47	Osteoporosis	9.9%
48	Periostitis	9.9%
49	Bone Demineralization, Pathologic	9.9%
50	Post-Traumatic Osteoporosis	9.9%
51	Alveolar Bone Loss	9.8%
52	Femur Head Necrosis	9.8%
53	Osteolysis	9.8%
54	Discitis	9.7%
55	Lordosis	9.7%
56	Spondylolysis	9.7%
57	kyphosis	9.7%
58	Craniosynostosis	8.9%
59	Syndactyly	8.9%
60	Brachycephaly	8.9%
61	Marfan Syndrome	8.8%
62	Fibromyalgia	8.5%
63	Polymyalgia Rheumatica	8.5%
64	Arthritis	8.5%
65	Bursitis	8.5%
66	Joint Instability	8.5%
67	Metatarsalgia	8.5%
68	Myofascial Pain Syndromes	8.5%
69	Rhabdomyolysis	8.5%
70	Synovitis	8.5%
71	Joint laxity	8.5%
72	Polyarthritis	8.5%
73	Frozen shoulder	8.5%
74	Patellofemoral Pain Syndrome	8.5%
75	Eosinophilic Granuloma	8.2%
76	Goldenhar Syndrome	8.1%
77	Mandibulofacial Dysostosis	8.1%
78	Tuberculosis, Spinal	7.7%
79	Basal Cell Nevus Syndrome	7.5%
80	Osteoarthritis, Spine	7.4%
81	Acrocephalosyndactylia	7.4%
82	Acromegaly	7.3%
83	Joint Tuberculosis	7.3%
84	Tuberculosis, Osteoarticular	7.3%
85	Bone Tuberculosis	7.3%
86	Antley-Bixler Syndrome Phenotype	7.3%
87	Spondylolisthesis	7.2%
88	Rubinstein-Taybi Syndrome	7%
89	Spondylarthropathies	7%
90	Poland Syndrome	6.8%
91	Rheumatic Fever	6.7%
92	Ankylosing spondylitis	6.6%
93	Cockayne Syndrome	6.6%
94	Hip Contracture	6.6%
95	Periarthritis	6.6%
96	Osteoporosis, Postmenopausal	6.5%
97	Gout	6.1%
98	Ischemic contracture	6%
99	Rickets	5.9%
100	Compartment syndromes	5.7%
101	Maxillary Diseases	5.7%
102	Tendinitis	5.7%
103	Tendinopathy	5.7%
104	Temporomandibular Joint Disorders	5.7%
105	Hemarthrosis	5.6%
106	Myositis	5.6%
107	Tietze's Syndrome	5.6%
108	Limb Deformities, Congenital	5.6%
109	Isaacs syndrome	5.6%
110	Craniofacial Abnormalities	5.6%
111	Myotonic Disorders	5.6%
112	Rheumatoid Arthritis	5.4%
113	Juvenile arthritis	5.4%
114	Osteoarthritis, Knee	5.4%
115	Arthritis, Psoriatic	5.3%
116	Bunion	4.9%
117	Fibrodysplasia Ossificans Progressiva	4.9%
118	Myoglobinuria	4.9%
119	Myositis Ossificans	4.9%
120	Pseudohypoparathyroidism	4.9%
121	Tenosynovitis	4.9%
122	Sacroiliitis	4.9%
123	Talipes	4.9%
124	Mastoiditis	4.8%
125	Petrositis	4.8%
126	Arthritis, Reactive	4.7%
127	Temporomandibular Joint Dysfunction Syndrome	4.5%
128	Medial Tibial Stress Syndrome	4.3%
129	Mitochondrial Myopathies	4.2%
130	Muscle Cramp	4.2%
131	Eosinophilia-Myalgia Syndrome	4.2%
132	Gastroschisis	4.2%
133	Muscle Rigidity	4.1%
134	Muscle Spasticity	4.1%
135	Cogwheel Rigidity	4.1%
136	Nuchal Rigidity	4.1%
137	Rheumatoid Nodule	4.1%
138	Osteomalacia	3.8%
139	Arthritis, Gouty	3.8%
140	Chronic Fatigue Syndrome	3.5%
141	Palatal Neoplasms	3.5%
142	Nail-Patella Syndrome	3.4%
143	Giant Cell Epulis	3.4%
144	Muscle Weakness	3.4%
145	Arthritis, Infectious	3.4%
146	Congenital clubfoot	3.4%
147	Vertical Talus	3.4%
148	Musculoskeletal Pain	3.3%
149	Jaw Abnormalities	3.3%
150	Familial Periodic Paralysis	3.3%
151	Anterior Compartment Syndrome	3.3%
152	Enthesopathy	3.3%
153	Arthritis, Experimental	3.3%
154	Abdominal Compartment Syndrome	3.3%
155	Arthralgia	3.3%
156	Polyarthralgia	3.3%
157	Felty Syndrome	3.3%
158	Amelia	3.3%
159	Arachnodactyly	3.3%
160	Ectromelia	3.3%
161	Hemimelia	3.3%
162	Phocomelia	3.3%
163	Sirenomelia	3.3%
164	Polymyositis	3.3%
165	Polydactyly	3.3%
166	Brachydactyly	3.3%
167	Plagiocephaly	3.3%
168	Lower Extremity Deformities, Congenital	3.3%
169	Upper Extremity Deformities, Congenital	3.3%
170	Laryngomalacia	2.9%
171	Myalgia	2.7%
172	Rheumatoid Vasculitis	2.7%
173	Prognathism	2.7%
174	Hip Dislocation	2.6%
175	Shoulder Dislocation	2.6%
176	Hip Dysplasia	2.6%
177	Nose Neoplasms	2.5%
178	Muscular Dystrophy	2.5%
179	Orbital Myositis	2.5%
180	Dupuytren Contracture	2.5%
181	Pyomyositis	2.5%
182	Renal Osteodystrophy	2.4%
183	Renal rickets	2.4%
184	Sicca Syndrome	2.3%
185	Sjogren's Syndrome	2.3%
186	Micrognathism	2.1%
187	Pierre Robin Syndrome	2.1%
188	Myotonic Dystrophy	2%
189	Maxillofacial Abnormalities	2%
190	Myotonia Congenita	2%
191	Bronchomalacia	2%
192	Tracheomalacia	2%
193	Microcephaly	1.9%
194	Macrocephaly	1.9%
195	Hypokalemic periodic paralysis	1.9%
196	Shoulder Pain	1.9%
197	Retrognathia	1.8%
198	Mitochondrial Encephalomyopathies	1.6%
199	Welander Distal Myopathy	1.6%
200	Cleft Palate	1.5%
201	Noonan Syndrome	1.4%
202	Dermatomyositis	1.3%
203	Muscular Dystrophy, Duchenne	1.3%
204	Porencephaly	1.3%
205	Holoprosencephaly	1.2%
206	Familial Hypophosphatemic Rickets	1.1%
207	Radicular Cyst	0.8%
208	MELAS Syndrome	0.6%
209	Kearns-Sayre syndrome	0.6%

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