MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Bronchopulmonary Dysplasia

(UMLS:C0006287)

Definition:: A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
UMLS ID:: C0006287
MeSH ID:: D001997

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.520.750.500

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.614.521.125

Synonym(s)

Bronchopulmonary Dysplasia

BPD

BPD - Bronchopulmonary dysplasia

BRONCHOPULMONARY DYSPLASIA

Bronchopulmonary dysplasia

Bronchopulmonary dysplasia of newborn

Chronic lung disease of prematurity

Perinatal bronchopulmonary dysplasia

Ventilator lung in newborn

10.

bronchopulmonary dysplasia

11.

bronchopulmonary dysplasia (BPD)

12.

bronchopulmonary dysplasia of fetus or newborn

13.

bronchopulmonary; dysplasia

14.

chronic lung disease of babies

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	solufenum	FAERS: 95		US FAERS
2	Indomethacin	FAERS: 41	12241754	CTD OFFSIDES US FAERS
3	Sertraline	FAERS: 14		US FAERS
4	Ibuprofen	FAERS: 13		SIDER US FAERS
5	Paroxetine	FAERS: 10		US FAERS
6	Bosentan	FAERS: 8		US FAERS
7	Ondansetron	FAERS: 8		US FAERS
8	Dexamethasone	FAERS: 7	View details 1735831 2235226 2358896 2651132 2903296 7575834 8339005 8417533 9084709 9097827 9253312 9303216 9527943 11158452 11455412 11745009 15044641 16651362	CTD US FAERS
9	Fluoxetine	FAERS: 6		US FAERS
10	Acetaminophen	FAERS: 5		US FAERS
11	Methotrexate	FAERS: 4		US FAERS
12	Valproic Acid	FAERS: 3		US FAERS
13	Fenofibrate	FAERS: 2		US FAERS
14	Lorazepam	FAERS: 2		US FAERS
15	Norgestrel	FAERS: 2		US FAERS
16	NuvaRing	FAERS: 2		US FAERS
17	Paroxetine	FAERS: 2		US FAERS
18	treprostinil	FAERS: 2		US FAERS
19	Betamethasone	FAERS: 1	9097827 11745009	CTD US FAERS
20	Cisapride	FAERS: 1		OFFSIDES US FAERS
21	Citalopram	FAERS: 1		US FAERS
22	Desflurane	FAERS: 1		US FAERS
23	Duloxetine Hydrochloride	FAERS: 1		US FAERS
24	Fingolimod Hydrochloride	FAERS: 1		US FAERS
25	Hydrocortisone	FAERS: 1		US FAERS
26	Iloprost	FAERS: 1		US FAERS
27	Ipratropium	FAERS: 1		US FAERS
28	Levetiracetam	FAERS: 1		US FAERS
29	Methamphetamine	FAERS: 1		US FAERS
30	Micafungin	FAERS: 1		US FAERS
31	Nitroxyl	FAERS: 1		US FAERS
32	Penicillamine	FAERS: 1		US FAERS
33	Telmisartan	FAERS: 1		US FAERS
34	Topiramate	FAERS: 1		US FAERS
35	Valproic Acid	FAERS: 1		US FAERS
36	Zidovudine	FAERS: 1		OFFSIDES US FAERS
37	lepirudin	FAERS: 1		US FAERS
38	nitisinone	FAERS: 1		US FAERS
39	5-O-[1-[3,3-Diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydron;chloride			OFFSIDES
40	Alcohols			OFFSIDES
41	Ampicillin			OFFSIDES
42	Aripiprazole			OFFSIDES
43	Atazanavir Sulfate			OFFSIDES
44	Budesonide		11158452	CTD
45	Caffeine			OFFSIDES
46	Calcium Gluconate		6786090	CTD
47	Carteolol			OFFSIDES
48	Clindamycin			OFFSIDES
49	Clobetasol			OFFSIDES
50	Clobetasol			OFFSIDES
51	Cocaine			OFFSIDES
52	Fluconazole	Canada Vigilance: 1		Canada Vigilance
53	Furosemide		View details 2809941 3279919 3290820 6600297 6786090	CTD
54	Heroin			OFFSIDES
55	Lansoprazole			OFFSIDES
56	Mecamylamine		23757602	CTD
57	Methyldopa			OFFSIDES
58	Methylprednisolone		16651362	CTD
59	Miconazole			OFFSIDES
60	Nicardipine			OFFSIDES
61	Nicotine			OFFSIDES
62	Nitrofurantoin			OFFSIDES
63	Oxygen		View details 20812253 25831079 26272953 29180065	CTD
64	Phenobarbital			OFFSIDES
65	Sildenafil Citrate			OFFSIDES
66	Tenofovir			OFFSIDES
67	Tretinoin		16813970	CTD
68	Vitamin A		15713907 17377406 17426644	CTD
69	carbidopa, levodopa drug combination			OFFSIDES
70	mepronizine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Respiratory Distress Syndrome, Newborn	32.7%
2	Meconium Aspiration Syndrome	24.4%
3	Retinopathy of Prematurity	23.5%
4	Acute Lung Injury	23.1%
5	Persistent Fetal Circulation Syndrome	22.7%
6	Cystic Fibrosis	22.5%
7	Hyaline Membrane Disease	21.7%
8	Pneumoconiosis	20.7%
9	Abdominal Cramps	20.2%
10	Amniotic Band Syndrome	20.2%
11	Asphyxia Neonatorum	20.2%
12	Infantile Colic	20.2%
13	Pneumonia	17.1%
14	Lobar Pneumonia	17.1%
15	Respiratory Distress Syndrome, Adult	17.1%
16	Pneumonitis	17.1%
17	Atelectasis	16.9%
18	Pulmonary Hypertension	16.9%
19	Pulmonary Alveolar Proteinosis	16.9%
20	Pulmonary Edema	16.9%
21	Pulmonary Fibrosis	16.9%
22	Hamman-Rich syndrome	16.9%
23	Lung Diseases, Interstitial	16.9%
24	Lung Diseases, Obstructive	16.9%
25	Radiation Pneumonitis	16.7%
26	Radiation Fibrosis	16.7%
27	Leukomalacia, Periventricular	15.3%
28	Anemia, Neonatal	15.1%
29	Umbilical hernia	14.9%
30	Lung Diseases, Fungal	13.8%
31	Lung Abscess	13.5%
32	Lung Neoplasms	13.5%
33	Tuberculosis, Pulmonary	13.4%
34	Asbestosis	13.2%
35	Berylliosis	13.2%
36	Silicosis	13.2%
37	Bronchitis	12.9%
38	Hepatopulmonary Syndrome	12.8%
39	Pulmonary Embolism	12.5%
40	Pulmonary Eosinophilia	12.4%
41	Eosinophilic Pneumonia	12.4%
42	Neonatal Abstinence Syndrome	12.4%
43	Idiopathic Pulmonary Fibrosis	12.3%
44	Xeroderma	12.3%
45	Mobius Syndrome	12.3%
46	Congenital nystagmus	12%
47	Toxoplasmosis, Congenital	11.9%
48	Syphilis, Congenital	11.8%
49	Deformity	11.8%
50	Genetic Diseases, Inborn	11.8%
51	Scimitar Syndrome	11.4%
52	Bronchopneumonia	11.4%
53	Tracheobronchomegaly	10.9%
54	Acute Chest Syndrome	10.8%
55	Asthma	10.7%
56	Bronchial Diseases	10.6%
57	Pleural Diseases	10.6%
58	Respiration Disorders	10.6%
59	Thoracic Diseases	10.6%
60	Tracheal Diseases	10.6%
61	Paralysis, Obstetric	10.1%
62	Hemoptysis	10.1%
63	Congenital Hyperinsulinism	10.1%
64	Pleuropneumonia	9.9%
65	Aspiration Pneumonia	9.9%
66	Chronic Obstructive Airway Disease	9.9%
67	Middle Lobe Syndrome	9.9%
68	Bronchitis, Chronic	9.8%
69	Primary Ciliary Dyskinesia	9.4%
70	Transfusion-Related Acute Lung Injury	9.3%
71	Fetal Diseases	8.8%
72	Pleurisy	8.5%
73	Tracheitis	8.5%
74	Pneumonia, Viral	8.3%
75	Laryngeal Diseases	8.3%
76	Nose Diseases	8.3%
77	Kartagener Syndrome	8.1%
78	Pneumonia, Bacterial	8.1%
79	Choanal Atresia	8%
80	Laryngocele	8%
81	Respiratory Tract Infections	8%
82	Beckwith-Wiedemann Syndrome	7.9%
83	Wolf-Hirschhorn Syndrome	7.9%
84	Bronchiolitis	7.9%
85	Multiple Pulmonary Nodules	7.9%
86	Granuloma, Respiratory Tract	7.8%
87	Respiratory Hypersensitivity	7.8%
88	Respiratory Tract Fistula	7.8%
89	Ichthyosis, X-Linked	7.7%
90	Histiocytosis, Langerhans-Cell	7.4%
91	Pulmonary Aspergillosis	7.4%
92	Bronchopulmonary Aspergillosis	7.4%
93	Sarcoidosis, Pulmonary	7.4%
94	Ophthalmia Neonatorum	7.3%
95	Pulmonary Infarction	7.3%
96	Aicardi's syndrome	7.1%
97	Laryngitis	6.9%
98	Rhinitis	6.9%
99	Vocal Cord Dysfunction	6.9%
100	Bronchial Fistula	6.8%
101	Pleural Neoplasms	6.8%
102	Abnormalities, Drug-Induced	6.7%
103	Situs Inversus	6.7%
104	CHARGE Syndrome	6.7%
105	Smith-Magenis syndrome	6.7%
106	Aspergillosis, Allergic Bronchopulmonary	6.6%
107	Cri-du-Chat Syndrome	6.6%
108	Down Syndrome	6.6%
109	Holoprosencephaly	6.6%
110	Trisomy 21	6.6%
111	Nesidioblastosis	6.5%
112	Pulmonary Emphysema	6.5%
113	Pneumonia, Lipid	6.5%
114	Sjogren-Larsson Syndrome	6.4%
115	Granuloma, Laryngeal	6.3%
116	Laryngostenosis	6.1%
117	Granulomatosis with polyangiitis	5.9%
118	Hyperkeratosis, Epidermolytic	5.8%
119	Ectodermal Dysplasia	5.7%
120	Aplasia Cutis Congenita	5.7%
121	Nail-Patella Syndrome	5.6%
122	Prader-Willi Syndrome	5.6%
123	Altitude Sickness	5.6%
124	Bronchospasm	5.6%
125	Bronchiectasis	5.6%
126	Chylothorax	5.6%
127	Hydropneumothorax	5.6%
128	Hydrothorax	5.6%
129	Pneumothorax	5.6%
130	Respiratory Insufficiency	5.6%
131	Tracheal Neoplasms	5.6%
132	Tracheal Stenosis	5.6%
133	Bronchial Hyperreactivity	5.6%
134	Respiratory Depression	5.6%
135	Respiratory Failure	5.6%
136	Fragile X Syndrome	5.5%
137	Rubinstein-Taybi Syndrome	5.5%
138	Sinusitis	5.4%
139	Bronchial Neoplasms	5.3%
140	Eye Abnormalities	5.3%
141	Neoplastic Syndromes, Hereditary	5.3%
142	Cardiovascular Abnormalities	5.3%
143	Bronchiolitis Obliterans	5.3%
144	Skin Abnormalities	5.1%
145	Lymphatic Abnormalities	5.1%
146	Congenital Microtia	5.1%
147	Multiple Epiphyseal Dysplasia	5%
148	Osteochondrodysplasias	5%
149	Pelger-Huet Anomaly	5%
150	Werner Syndrome	5%
151	Myasthenic Syndromes, Congenital	5%
152	Kernicterus	5%
153	Congenital diaphragmatic hernia	5%
154	Cockayne Syndrome	5%
155	Farmer's Lung	5%
156	Blastomycosis	4.9%
157	Anti-Glomerular Basement Membrane Disease	4.9%
158	Pleural Effusion, Malignant	4.9%
159	Laryngeal neoplasm	4.9%
160	Marfan Syndrome	4.9%
161	Alstrom Syndrome	4.7%
162	Anencephaly	4.6%
163	Familial Mediterranean Fever	4.4%
164	Prune Belly Syndrome	4.4%
165	Twins, Conjoined	4.4%
166	Waardenburg Syndrome	4.4%
167	Laryngomalacia	4.4%
168	Anemia, Sickle Cell	4.4%
169	Thalassemia	4.4%
170	Muscular Dystrophy, Duchenne	4.4%
171	Polycystic Kidney Diseases	4.4%
172	Williams Syndrome	4.4%
173	Granuloma, Lethal Midline	4.3%
174	Laryngeal Edema	4.3%
175	Nose Deformities, Acquired	4.3%
176	Respiratory Aspiration	4.3%
177	Urogenital Abnormalities	4.3%
178	Apnea	4.2%
179	Cheyne-Stokes Respiration	4.2%
180	Common Cold	4.2%
181	Dyspnea	4.2%
182	Hemothorax	4.2%
183	Hyperventilation	4.2%
184	Influenza	4.2%
185	Mouth Breathing	4.2%
186	Tachypnea	4.2%
187	Catarrh	4.2%
188	Dwarfism	4.2%
189	Severe Acute Respiratory Syndrome	4.1%
190	Laryngopharyngeal Reflux	4.1%
191	Smith-Lemli-Opitz Syndrome	4.1%
192	Albinism	4%
193	Fetal Growth Retardation	4%
194	Muscular Dystrophy	4%
195	Osteogenesis Imperfecta	4%
196	Fetal Hypoxia	4%
197	Fetal Alcohol Spectrum Disorders	4%
198	Laryngospasm	4%
199	Asthma, Exercise-Induced	3.9%
200	Status Asthmaticus	3.9%
201	Invasive Pulmonary Aspergillosis	3.9%
202	Retinal Dysplasia	3.9%
203	Maxillofacial Abnormalities	3.9%
204	Dural Arteriovenous Fistula	3.9%
205	Rett Syndrome	3.9%
206	Aniridia	3.9%
207	Dextrocardia	3.8%
208	Epidermolysis Bullosa	3.8%
209	Nose Neoplasms	3.8%
210	Rhinoscleroma	3.7%
211	Classical Lissencephalies and Subcortical Band Heterotopias	3.6%
212	Mucopolysaccharidosis II	3.5%
213	Kallmann Syndrome	3.5%
214	Pharyngitis	3.4%
215	Nasal Polyps	3.4%
216	Asthma, Occupational	3.4%
217	Autoimmune Lymphoproliferative Syndrome	3.4%
218	Anophthalmos	3.4%
219	Anus, Imperforate	3.4%
220	Hydranencephaly	3.4%
221	Microphthalmos	3.4%
222	Neural Tube Defects	3.4%
223	Tethered Cord Syndrome	3.4%
224	Iniencephaly	3.4%
225	Craniorachischisis	3.4%
226	Limb Deformities, Congenital	3.4%
227	Exencephaly	3.4%
228	Septo-Optic Dysplasia	3.4%
229	Craniofacial Abnormalities	3.4%
230	Cortical Dysplasia	3.4%
231	Malformations of Cortical Development	3.4%
232	Anorectal Malformations	3.4%
233	Chorioamnionitis	3.3%
234	Hoarseness	3.3%
235	Pertussis	3.3%
236	Amino Acid Metabolism, Inborn Errors	3.3%
237	Bloom Syndrome	3.3%
238	Carbohydrate Metabolism, Inborn Errors	3.3%
239	Metal Metabolism, Inborn Errors	3.3%
240	Progeria	3.3%
241	Lysosomal Storage Diseases	3.3%
242	Cytochrome-c Oxidase Deficiency	3.3%
243	Peroxisomal Disorders	3.3%
244	Paranasal Sinus Neoplasms	3.3%
245	Airway Obstruction	3.3%
246	Choking	3.3%
247	Epiglottitis	3.3%
248	Angioedemas, Hereditary	3.3%
249	Mediastinitis	3.3%
250	Wiskott-Aldrich Syndrome	3.3%
251	Bronchomalacia	3.3%
252	Tracheomalacia	3.3%
253	Menkes Kinky Hair Syndrome	3.2%
254	Sickle Cell Trait	3.2%
255	Tuberous Sclerosis	3.2%
256	Polycystic Kidney, Autosomal Dominant	3.2%
257	Neuronal Ceroid-Lipofuscinoses	3%
258	Refsum Disease	3%
259	Microcephaly	3%
260	Macrocephaly	3%
261	Pseudoxanthoma Elasticum	3%
262	Myotonic Dystrophy	2.9%
263	Voice Disorders	2.9%
264	Voice Disturbance	2.9%
265	Asthma, Aspirin-Induced	2.8%
266	Abnormalities, Radiation-Induced	2.8%
267	Eosinophilic Granuloma	2.8%
268	Epistaxis	2.8%
269	Craniosynostosis	2.8%
270	Syndactyly	2.8%
271	Brachycephaly	2.8%
272	Turner Syndrome	2.8%
273	Charcot-Marie-Tooth Disease	2.8%
274	Antley-Bixler Syndrome Phenotype	2.8%
275	Zellweger Syndrome	2.7%
276	Blepharophimosis	2.7%
277	Mouth Abnormalities	2.7%
278	Hay fever	2.7%
279	Rhinitis, Allergic, Perennial	2.7%
280	Klinefelter Syndrome	2.7%
281	Porencephaly	2.7%
282	Cutis Laxa	2.7%
283	Esophageal Atresia	2.7%
284	Intestinal Atresia	2.7%
285	Horseshoe Kidney	2.7%
286	Pectus excavatum	2.7%
287	Xeroderma Pigmentosum	2.7%
288	Acrocephalosyndactylia	2.7%
289	Klippel-Feil Syndrome	2.7%
290	Retinitis Pigmentosa	2.7%
291	Gastroschisis	2.7%
292	Synostosis	2.7%
293	Pigmentary retinopathy	2.7%
294	Acrodermatitis	2.6%
295	Lymphangiectasis, Intestinal	2.6%
296	Porokeratosis	2.6%
297	Gianotti-Crosti Syndrome	2.6%
298	Keratoderma, Palmoplantar	2.6%
299	Chronic granulomatous disease	2.6%
300	Welander Distal Myopathy	2.6%
301	Adrenoleukodystrophy	2.6%
302	Amyloid Neuropathies, Familial	2.5%
303	Hepatolenticular Degeneration	2.5%
304	Mediastinal Cyst	2.5%
305	Pericardial Cyst	2.5%
306	Thymic Cyst	2.5%
307	Noonan Syndrome	2.5%
308	Croup	2.5%
309	Mediastinal Emphysema	2.5%
310	Rhinitis, Vasomotor	2.5%
311	Hypoventilation	2.5%
312	Acidosis, Respiratory	2.5%
313	Alkalosis, Respiratory	2.5%
314	Amelia	2.5%
315	Arachnodactyly	2.5%
316	Ectopia Cordis	2.5%
317	Ectromelia	2.5%
318	Hemimelia	2.5%
319	Meningomyelocele	2.5%
320	Phocomelia	2.5%
321	Sirenomelia	2.5%
322	Sleep Apnea Syndromes	2.5%
323	Spina Bifida	2.5%
324	Polydactyly	2.5%
325	Brachydactyly	2.5%
326	Plagiocephaly	2.5%
327	Lower Extremity Deformities, Congenital	2.5%
328	Upper Extremity Deformities, Congenital	2.5%
329	Single umbilical artery	2.5%
330	Fabry Disease	2.4%
331	Alkaptonuria	2.4%
332	Glycogen Storage Disease	2.4%
333	Hypophosphatasia	2.4%
334	Propionic acidemia	2.4%
335	Dihydropyrimidine Dehydrogenase Deficiency	2.4%
336	Cystinosis	2.4%
337	Galactosemias	2.4%
338	Urea Cycle Disorders, Inborn	2.4%
339	Tyrosinemias	2.4%
340	Vocal Cord Paralysis	2.4%
341	Glycogen storage disease type II	2.4%
342	Basal Cell Nevus Syndrome	2.4%
343	Hydrops Fetalis	2.4%
344	Poland Syndrome	2.3%
345	Cleft Palate	2.3%
346	Mucopolysaccharidosis III	2.3%
347	Jaw Abnormalities	2.3%
348	Arthrogryposis	2.3%
349	Choledochal Cyst	2.3%
350	Duane Retraction Syndrome	2.3%
351	Hermaphroditism	2.3%
352	Disorders of Sex Development	2.3%
353	Ataxia Telangiectasia	2.2%
354	Cryptorchidism	2.2%
355	Porphyrias, Hepatic	2.2%
356	Hypospadias	2.2%
357	Central Nervous System Cysts	2.2%
358	Dandy-Walker Syndrome	2.2%
359	Peutz-Jeghers Syndrome	2.2%
360	Myotonia Congenita	2.2%
361	Thrombasthenia	2.2%
362	Antithrombin III Deficiency	2.2%
363	Protein C Deficiency	2.2%
364	Brain Diseases, Metabolic, Inborn	2.2%
365	Afibrinogenemia	2.2%
366	Dystonia Musculorum Deformans	2.2%
367	Factor VII Deficiency	2.2%
368	Factor X Deficiency	2.2%
369	Factor XII Deficiency	2.2%
370	Hemophilia A	2.2%
371	POEMS Syndrome	2.2%
372	Activated Protein C Resistance	2.2%
373	Factor II deficiency	2.2%
374	Factor VIII Deficiency	2.2%
375	Factor V deficiency	2.2%
376	Factor XI Deficiency	2.2%
377	Hypoprothrombinemias	2.2%
378	Fanconi Anemia	2.2%
379	Optic Atrophy, Hereditary, Leber	2.2%
380	Lafora Disease	2.2%
381	Unverricht-Lundborg Syndrome	2.2%
382	Anemia, Diamond-Blackfan	2.2%
383	Hyperphosphaturia	2.2%
384	Maxillary Sinus Neoplasms	2.2%
385	Canavan Disease	2.1%
386	Alexander Disease	2.1%
387	Dermal Sinus	2%
388	Spina Bifida Cystica	2%
389	Spina Bifida Occulta	2%
390	Lissencephaly	2%
391	Polymicrogyria	2%
392	Pachygyria	2%
393	Schizencephaly	2%
394	Periventricular Nodular Heterotopia	2%
395	Glycogen Storage Disease Type I	2%
396	Glycogen Storage Disease Type V	2%
397	Homocystinuria	2%
398	Tonsillitis	2%
399	Leigh Disease	2%
400	Aortic coarctation	2%
401	Cor Triatriatum	2%
402	Coronary Vessel Anomalies	2%
403	Dental Enamel Hypoplasia	2%
404	Patent ductus arteriosus	2%
405	Dyspnea, Paroxysmal	2%
406	Ebstein Anomaly	2%
407	Heart Septal Defects	2%
408	Hypodontia	2%
409	Macrostomia	2%
410	Meningocele	2%
411	Microstomia	2%
412	Respiratory Paralysis	2%
413	Tetralogy of Fallot	2%
414	Transposition of Great Vessels	2%
415	Hypoplastic Left Heart Syndrome	2%
416	May-Thurner Syndrome	2%
417	Encephalocele	2%
418	Craniofacial Dysostosis	2%
419	Multiple Endocrine Neoplasia	2%
420	Hypolipoproteinemias	1.9%
421	Papillon-Lefevre Disease	1.9%
422	Wolff-Parkinson-White Syndrome	1.9%
423	Gaucher Disease	1.9%
424	Hyperlipidemia, Familial Combined	1.9%
425	Hyperlipoproteinemia Type III	1.9%
426	Pectus carinatum	1.9%
427	Micrognathism	1.9%
428	Pierre Robin Syndrome	1.9%
429	Bladder Exstrophy	1.9%
430	Congenital Hypothyroidism	1.9%
431	Epispadias	1.9%
432	Dermatitis, Atopic	1.9%
433	Multicystic Dysplastic Kidney	1.9%
434	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
435	Tay-Sachs Disease	1.8%
436	Retrognathia	1.7%
437	Niemann-Pick Disease, Type C	1.7%
438	Familial Periodic Paralysis	1.7%
439	Behcet Syndrome	1.7%
440	Aphonia	1.6%
441	Long QT Syndrome	1.6%
442	Platybasia	1.6%
443	Retropharyngeal Abscess	1.6%
444	Tricuspid Atresia	1.6%
445	Arrhythmogenic Right Ventricular Dysplasia	1.6%
446	Dysphonia	1.6%
447	Gonadal Dysgenesis	1.6%
448	Adrenogenital Syndrome	1.6%
449	Ovotesticular Disorders of Sex Development	1.6%
450	Lactose Intolerance	1.6%
451	Variegate Porphyria	1.6%
452	Acute intermittent porphyria	1.6%
453	Porphyria Cutanea Tarda	1.6%
454	Hyperhomocysteinemia	1.6%
455	Sleep Apnea, Obstructive	1.6%
456	Sleep Apnea, Central	1.6%
457	Aortopulmonary Septal Defect	1.6%
458	Double Outlet Right Ventricle	1.6%
459	Endocardial Cushion Defects	1.6%
460	Myocardial bridging	1.6%
461	Aorticopulmonary Septal Defect	1.6%
462	Renal Aminoacidurias	1.6%
463	Fanconi Syndrome	1.6%
464	Pseudohypoaldosteronism	1.6%
465	Liddle Syndrome	1.6%
466	Hyperlipoproteinemia Type IV	1.6%
467	Hyperlipoproteinemia Type V	1.6%
468	Hyperandrogenism	1.6%
469	Hypoalphalipoproteinemias	1.6%
470	Prognathism	1.5%
471	Huntington Disease	1.5%
472	Truncus Arteriosus, Persistent	1.4%
473	Goldenhar Syndrome	1.4%
474	Gout	1.4%
475	Nasopharyngitis	1.4%
476	Multiple Endocrine Neoplasia Type 1	1.4%
477	Pseudohypoparathyroidism	1.4%
478	Friedreich Ataxia	1.4%
479	Renal tubular acidosis	1.4%
480	Hypokalemic periodic paralysis	1.4%
481	Mandibulofacial Dysostosis	1.4%
482	Romano-Ward Syndrome	1.3%
483	Cystinuria	1.3%
484	Nephroblastoma	1.3%
485	Denys-Drash Syndrome	1.3%
486	Talipes	1.2%
487	Adenomatous Polyposis Coli	1.2%
488	Arthritis, Gouty	1.2%
489	Congenital clubfoot	1.1%
490	Vertical Talus	1.1%
491	Familial Hypophosphatemic Rickets	1.1%
492	Peritonsillar Abscess	1.1%
493	Glycosuria, Renal	1.1%
494	Arteriovenous fistula	1%
495	MELAS Syndrome	0.9%

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