MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

neurofibroma

(UMLS:C0027830)

Definition:: A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)
UMLS ID:: C0027830
MeSH ID:: D009455

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.580.600.580

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.551.775.500.750|C10.668.829.725.500.600

Synonym(s)

neurofibroma

NEUROFIBROMA, BENIGN

Neurofibroma

Neurofibroma (WHO Grade I)

Neurofibroma NOS

Neurofibroma, NOS

Neurofibroma, no ICD-O subtype

Neurofibroma, no International Classification of Diseases for Oncology subtype

Neurofibromas

10.

[M]Neurofibromas

11.

neurofibromas

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 14	US FAERS
2	Imatinib Mesylate	FAERS: 4	US FAERS
3	Medroxyprogesterone Acetate	FAERS: 4	US FAERS
4	Imatinib Mesylate	FAERS: 2	US FAERS
5	NuvaRing	FAERS: 2	US FAERS
6	Ciprofloxacin	FAERS: 1	US FAERS
7	Dasatinib	FAERS: 1	US FAERS
8	Desogestrel	FAERS: 1	US FAERS
9	Fingolimod Hydrochloride	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
10	Phenytoin	FAERS: 1	US FAERS
11	Risedronic Acid	FAERS: 1	US FAERS
12	Sitagliptin Phosphate	FAERS: 1	US FAERS
13	Teriparatide	FAERS: 1	US FAERS
14	Thalidomide	FAERS: 1	US FAERS
15	apixaban	FAERS: 1	US FAERS
16	etonogestrel	FAERS: 1	US FAERS
17	Medroxyprogesterone		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Neuroma	24.1%
2	Neurilemmoma	19.9%
3	Complex Regional Pain Syndromes	19.8%
4	Neuroectodermal Tumors	19.5%
5	Motor Neuron Disease	18.7%
6	Meningioma	18.1%
7	Peripheral Nerve Injuries	16.7%
8	Neuritis	16.6%
9	Polyneuritis	16.6%
10	Radiculitis	16.6%
11	Polyneuropathy	16.6%
12	Mononeuritis	16.6%
13	Mononeuropathies	16.6%
14	Brachial Plexus Neuropathies	16.6%
15	Radiculopathy	16.6%
16	Mononeuropathy Multiplex	16.6%
17	Nerve Root Compression	16.6%
18	Causalgia	16.4%
19	Guillain-Barre Syndrome	16.3%
20	Brachial Plexus Neuritis	16.1%
21	Neuralgic Amyotrophy	16.1%
22	Stiff-Person Syndrome	16%
23	Neoplasms, Neuroepithelial	15.6%
24	Gliomatosis cerebri	15.6%
25	Neuromuscular Junction Diseases	15.2%
26	Polyradiculoneuropathy	15%
27	Polyradiculoneuritis	15%
28	Cranial nerve diseases	14.9%
29	Demyelinating Diseases	14.9%
30	Demyelination	14.9%
31	Chronobiology Disorders	14.9%
32	Central Nervous System Neoplasms	14.9%
33	Isaacs syndrome	13.5%
34	Tarsal Tunnel Syndrome	13.5%
35	Cauda Equina Syndrome	13.5%
36	Diabetic Neuropathies	13.4%
37	Diabetic Amyotrophy	13.4%
38	Diabetic Autonomic Neuropathy	13.4%
39	Neuralgia	13.3%
40	Neuropathic pain	13.3%
41	Acrodynia	12.9%
42	melanoma	12.9%
43	Craniopharyngioma	12.9%
44	Neuroectodermal Tumor, Melanotic	12.9%
45	Neuroendocrine Tumors	12.9%
46	Myopathy	12.7%
47	Trauma, Nervous System	12.4%
48	Acoustic Neuroma	12.4%
49	leukemia	12.3%
50	Neoplasms, Germ Cell and Embryonal	12.3%
51	Neoplasms, Glandular and Epithelial	12.3%
52	Germ Cell Cancer	12.3%
53	Neurologic Manifestations	12%
54	Neurotoxicity Syndromes	12%
55	Medulloblastoma	12%
56	Poliomyelitis	11.9%
57	Chronic Fatigue Syndrome	11.8%
58	Spinal Muscular Atrophy	11.7%
59	Progressive Muscular Atrophy	11.7%
60	Hand-Arm Vibration Syndrome	11.7%
61	Reflex Sympathetic Dystrophy	11.7%
62	Multiple System Atrophy	11.3%
63	Carpal Tunnel Syndrome	11.3%
64	Optic Nerve Glioma	11.3%
65	Adenoma, Acidophil	11.2%
66	Ganglioneuroma	11.2%
67	Glioma	11.2%
68	Sciatica	11.2%
69	Malignant Glioma	11.2%
70	Lambert-Eaton Myasthenic Syndrome	11.2%
71	Restless Legs Syndrome	11.1%
72	Amyotrophic Lateral Sclerosis	11%
73	Myasthenia Gravis	11%
74	Ocular Motility Disorders	11%
75	Cyclophoria	11%
76	Central Nervous System Cysts	10.8%
77	Progressive bulbar palsy	10.4%
78	Bulbar palsy	10.4%
79	Carcinoid Tumor	10.4%
80	Miller Fisher Syndrome	10.3%
81	Brain Neoplasms	10.3%
82	Spinal Cord Neoplasms	10.3%
83	Sleep Wake Disorders	10.2%
84	Subacute Combined Degeneration	10.2%
85	Sciatic Neuropathy	10%
86	Ulnar Neuropathies	10%
87	Lesion of Sciatic Nerve	10%
88	Ulnar Neuritis	10%
89	Radial nerve compression	10%
90	Radial Tunnel Syndrome	10%
91	Peroneal Neuropathies	10%
92	Radial Neuropathy	10%
93	Median Neuropathy	10%
94	Sciatic Nerve Palsy	10%
95	Femoral Neuropathy	10%
96	Tibial Neuropathy	10%
97	Ulnar Nerve Palsy	10%
98	Radial nerve palsy	10%
99	Encephalomyelitis	9.9%
100	Histiocytic Disorders, Malignant	9.9%
101	Prion Diseases	9.9%
102	Autonomic Dysreflexia	9.9%
103	Hutchinson's Melanotic Freckle	9.8%
104	Melanoma, Amelanotic	9.8%
105	Paraneoplastic Encephalomyelitis	9.7%
106	Carcinosarcoma	9.7%
107	Hemangiosarcoma	9.7%
108	lymphangiosarcoma	9.7%
109	Paraganglioma	9.6%
110	Melanoma, Experimental	9.5%
111	Botulism	9.4%
112	Tuberous Sclerosis	9.4%
113	Nervous System Neoplasms	9.3%
114	Ophthalmoplegic Migraine	9.2%
115	Cubital Tunnel Syndrome	9.1%
116	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9%
117	Astrocytoma	9%
118	Ependymoma	9%
119	oligodendroglioma	9%
120	Ganglioglioma	9%
121	gliosarcoma	9%
122	Anaplastic astrocytoma	9%
123	Anaplastic Oligodendroglioma	9%
124	Meningeal Neoplasms	8.7%
125	Malignant Carcinoid Syndrome	8.6%
126	Spinal Cord Injuries	8.5%
127	Marchiafava-Bignami Disease	8.5%
128	Sturge-Weber Syndrome	8.5%
129	Myelitis, Transverse	8.4%
130	Carcinoma 256, Walker	8.4%
131	Parkinson Disease	8.4%
132	Meningoencephalitis	8.4%
133	Composite Lymphoma	8.4%
134	Neuritis, Autoimmune, Experimental	8.3%
135	Lymphoma	8.3%
136	Asterixis	8.3%
137	Ballismus	8.3%
138	Opsoclonus-Myoclonus Syndrome	8.2%
139	Thoracic Outlet Syndrome	8.2%
140	Leukemia, Plasma Cell	8.1%
141	Pheochromocytoma	8%
142	Glioblastoma	7.9%
143	Neuroblastoma	7.9%
144	Glioblastoma Multiforme	7.9%
145	Brain Diseases	7.8%
146	Dysautonomia	7.8%
147	Meningitis	7.8%
148	Movement Disorders	7.8%
149	Pachymeningitis	7.8%
150	Spinal Cord Diseases	7.8%
151	Vagus Nerve Disorder	7.8%
152	Glossopharyngeal Neuralgia	7.8%
153	Abducens Nerve Diseases	7.8%
154	Heavy Metal Poisoning, Nervous System	7.8%
155	Tauopathies	7.8%
156	Trochlear Nerve Diseases	7.8%
157	Lewy Body Disease	7.8%
158	Dandy-Walker Syndrome	7.7%
159	Basal cell carcinoma	7.7%
160	Carcinoma, Papillary	7.7%
161	Squamous cell carcinoma	7.7%
162	Chondrosarcoma	7.7%
163	Cystadenoma	7.7%
164	leiomyosarcoma	7.7%
165	liposarcoma	7.7%
166	Mesothelioma	7.7%
167	synovial sarcoma	7.7%
168	Angiomyolipoma	7.7%
169	Clear Cell Sarcoma of Soft Tissue	7.7%
170	Alveolar Soft Part Sarcoma	7.7%
171	Sarcoma, Myeloid	7.7%
172	Carcinoma, Basal Cell	7.7%
173	Trophoblastic Neoplasms	7.7%
174	Pneumocephalus	7.7%
175	Leukemia, Experimental	7.7%
176	Hamartoma	7.7%
177	Neoplasms, Hormone-Dependent	7.7%
178	Neoplasms, Multiple Primary	7.7%
179	Neuromuscular Diseases	7.7%
180	Paraneoplastic Syndromes	7.7%
181	Precancerous Conditions	7.7%
182	Neoplasms, Second Primary	7.7%
183	Retinoblastoma	7.5%
184	Ganglioneuroblastoma	7.4%
185	Sleep Disorders, Circadian Rhythm	7.3%
186	Adenoma	7.3%
187	Ameloblastoma	7.3%
188	Angiokeratoma	7.3%
189	Carcinoma	7.3%
190	Chordoma	7.3%
191	Hemangioma	7.3%
192	hemangiopericytoma	7.3%
193	Lymphangioma	7.3%
194	Mesenchymoma	7.3%
195	Nevus	7.3%
196	Teratoma	7.3%
197	Hepatoblastoma	7.3%
198	Mixed Tumor, Mullerian	7.3%
199	Germinoma	7.3%
200	Teratocarcinoma	7.3%
201	Angiofibroma	7.3%
202	Sarcoma	7.3%
203	Epithelioma	7.3%
204	Carcinoma, Ehrlich Tumor	7.2%
205	Dermoid Cyst	7.2%
206	Carcinoma, Lewis Lung	7.2%
207	Myelitis	7.2%
208	Neuroleptic Malignant Syndrome	7.1%
209	Myelinolysis, Central Pontine	7.1%
210	Limbic Encephalitis	7.1%
211	Charcot-Marie-Tooth Disease	7.1%
212	Progressive supranuclear palsy	7%
213	Myositis	6.9%
214	Myotonic Disorders	6.9%
215	Myasthenic Syndromes, Congenital	6.9%
216	Striatonigral Degeneration	6.9%
217	Dyskinesia, Drug-Induced	6.8%
218	Polyradiculopathy	6.8%
219	Carcinoid Heart Disease	6.7%
220	Cystadenocarcinoma	6.7%
221	Fibrosarcoma	6.7%
222	Osteosarcoma	6.7%
223	Mucoepidermoid Carcinoma	6.7%
224	Epidural Abscess	6.7%
225	Olfactory Nerve Injuries	6.7%
226	Supratentorial Neoplasms	6.7%
227	Leukemia, Radiation-Induced	6.7%
228	Leukoencephalitis, Acute Hemorrhagic	6.6%
229	Central Nervous System Infection	6.5%
230	Optic Neuropathy	6.5%
231	MPTP Poisoning	6.5%
232	Paraneoplastic Cerebellar Degeneration	6.5%
233	Facial Nerve Diseases	6.4%
234	Craniocerebral Trauma	6.4%
235	Parasomnia	6.4%
236	Dyssomnias	6.4%
237	Neuromyelitis Optica	6.3%
238	Myasthenia Gravis, Autoimmune, Experimental	6.3%
239	Vestibulocochlear Nerve Diseases	6.3%
240	Decerebrate State	6.3%
241	Hemiparesis	6.3%
242	Hydranencephaly	6.3%
243	Meningism	6.3%
244	Neural Tube Defects	6.3%
245	Paresis	6.3%
246	Seizures	6.3%
247	Sensation Disorders	6.3%
248	Tethered Cord Syndrome	6.3%
249	Complex partial seizures	6.3%
250	Iniencephaly	6.3%
251	Craniorachischisis	6.3%
252	Exencephaly	6.3%
253	Monoparesis	6.3%
254	Septo-Optic Dysplasia	6.3%
255	Cortical Dysplasia	6.3%
256	Neurogenic Inflammation	6.3%
257	Gait Disorders, Neurologic	6.3%
258	Neuromuscular Manifestations	6.3%
259	Malformations of Cortical Development	6.3%
260	Encephalomyelitis, Acute Disseminated	6.2%
261	Adenofibroma	6.2%
262	Fibroadenoma	6.2%
263	Malignant Fibrous Histiocytoma	6.2%
264	Sweating, Gustatory	6.2%
265	Auriculotemporal Syndrome	6.2%
266	Akathisia, Drug-Induced	6.2%
267	Choriocarcinoma	6.2%
268	Carcinoma, Lobular	6.2%
269	Cyst	6.2%
270	Neoplastic Processes	6.2%
271	Neoplastic Syndromes, Hereditary	6.2%
272	Pregnancy Complications, Neoplastic	6.2%
273	Endometrial Stromal Sarcoma	6.2%
274	Neoplasms, Experimental	6.1%
275	Horner Syndrome	6.1%
276	Shy-Drager Syndrome	6.1%
277	Sarcoma, Experimental	6%
278	Brain Injuries	6%
279	Multiple Sclerosis	6%
280	Thymoma	6%
281	Facial Nerve Injuries	5.9%
282	Plasmacytoma	5.9%
283	Fibromyalgia	5.8%
284	Medial Tibial Stress Syndrome	5.8%
285	Malignant histiocytosis	5.8%
286	Leukemia L1210	5.8%
287	Leukemia P388	5.8%
288	Subdural Effusion	5.8%
289	Parkinsonian Disorders	5.8%
290	Histiocytic sarcoma	5.8%
291	Nocturnal Myoclonus Syndrome	5.8%
292	Acanthoma	5.8%
293	Amyloid Neuropathies, Familial	5.8%
294	Cerebellar Neoplasms	5.8%
295	Dystonia Musculorum Deformans	5.8%
296	POEMS Syndrome	5.8%
297	Mitochondrial Myopathies	5.8%
298	Meningeal Carcinomatosis	5.8%
299	Eosinophilia-Myalgia Syndrome	5.8%
300	Bowen's Disease	5.8%
301	Rhabdomyosarcoma	5.8%
302	Giant Cell Tumor of Bone	5.8%
303	Myotonia Congenita	5.6%
304	Lymphangioleiomyomatosis	5.5%
305	Leukoencephalopathy, Progressive Multifocal	5.5%
306	Multiple Endocrine Neoplasia	5.5%
307	Pupil Disorders	5.4%
308	Neurobehavioral Manifestations	5.4%
309	Myotonic Dystrophy	5.4%
310	Vasculitis, Central Nervous System	5.4%
311	Jet Lag Syndrome	5.3%
312	Dermatofibrosarcoma	5.3%
313	Dermatofibrosarcoma Protuberans	5.3%
314	Uveomeningoencephalitic Syndrome	5.2%
315	Vertigo	5.2%
316	Alcohol-Induced Disorders, Nervous System	5.2%
317	Brain Abscess	5.2%
318	Ophthalmoplegia	5.2%
319	External Ophthalmoplegia	5.2%
320	Neoplasms, Radiation-Induced	5.1%
321	Scrapie	4.9%
322	Central Cord Syndrome	4.9%
323	Familial Periodic Paralysis	4.9%
324	Brain Stem Neoplasms	4.9%
325	Huntington Disease	4.9%
326	Presenile dementia	4.9%
327	Senile dementia	4.9%
328	Meningitis, Bacterial	4.9%
329	Meningitis, Fungal	4.9%
330	Chorea	4.9%
331	Hodgkin Disease	4.9%
332	Lymphoma, Non-Hodgkin	4.9%
333	Sarcoma 180	4.8%
334	Epilepsy, Post-Traumatic	4.8%
335	Adenocarcinoma	4.8%
336	Carcinoma in Situ	4.8%
337	Carcinoma, Transitional Cell	4.8%
338	Phyllodes Tumor	4.8%
339	Dysgerminoma	4.8%
340	Hemangioendothelioma	4.8%
341	Lipoma	4.8%
342	Myoma	4.8%
343	Myxoma	4.8%
344	Papilloma	4.8%
345	Pseudomyxoma Peritonei	4.8%
346	Seminoma	4.8%
347	Papillomatosis	4.8%
348	Angiolipoma	4.8%
349	Myelolipoma	4.8%
350	Neoplasms, Bone Tissue	4.8%
351	Neoplasms, Fibrous Tissue	4.8%
352	Smooth Muscle Tumor	4.8%
353	Adenomatosis, Pulmonary	4.8%
354	Adenomatous Polyps	4.8%
355	Carcinoma, Large Cell	4.8%
356	Carcinoma, Small Cell	4.8%
357	Desmoplastic Small Round Cell Tumor	4.8%
358	Chondroma	4.8%
359	Enchondroma	4.8%
360	Alveolar rhabdomyosarcoma	4.8%
361	Alstrom Syndrome	4.7%
362	Pituitary Adenoma	4.6%
363	Pituitary Neoplasms	4.6%
364	Lupus Vasculitis, Central Nervous System	4.6%
365	Refsum Disease	4.6%
366	Nephroblastoma	4.6%
367	Voice Disorders	4.6%
368	Voice Disturbance	4.6%
369	Vocal Cord Paralysis	4.6%
370	Canavan Disease	4.5%
371	Alexander Disease	4.5%
372	Meige Syndrome	4.5%
373	Cerebral Ventriculitis	4.5%
374	Smith-Magenis syndrome	4.5%
375	Ataxia Telangiectasia	4.5%
376	Dural Arteriovenous Fistula	4.5%
377	Akinetic Mutism	4.5%
378	Anoxic Encephalopathy	4.5%
379	Arachnoiditis	4.5%
380	Basal Ganglia Diseases	4.5%
381	Brain Damage, Chronic	4.5%
382	Cerebellar Diseases	4.5%
383	Encephalitis	4.5%
384	Encephalomalacia	4.5%
385	Epilepsy	4.5%
386	Hydrocephalus	4.5%
387	Congenital Hydrocephalus	4.5%
388	Hypothalamic Diseases	4.5%
389	Aseptic Meningitis	4.5%
390	Syringomyelia	4.5%
391	Thalamic Diseases	4.5%
392	Intracranial Hypertension	4.5%
393	Aura	4.5%
394	Leukoencephalopathy	4.5%
395	Essential Tremor	4.5%
396	Neuroaxonal Dystrophies	4.5%
397	Familial Tremor	4.5%
398	Headache Disorders	4.5%
399	Intracranial Hypotension	4.5%
400	Brain Edema	4.5%
401	Brain Hypoxia	4.5%
402	Aqueductal Stenosis	4.5%
403	Pneumorrhachis	4.5%
404	Writer's Cramp	4.5%
405	Lymphomatoid Granulomatosis	4.4%
406	Mammary Neoplasms, Experimental	4.4%
407	Myalgia	4.3%
408	Basal Cell Nevus Syndrome	4.2%
409	Polymyositis	4.2%
410	Amblyopia	4.2%
411	Primary amyloidosis	4.2%
412	Neurofibrosarcoma	4.2%
413	Cerebrospinal Fluid Otorrhea	4.2%
414	Cerebrospinal Fluid Rhinorrhea	4.2%
415	Gait Ataxia	4.1%
416	Lafora Disease	4.1%
417	Unverricht-Lundborg Syndrome	4.1%
418	Abdominal Neoplasms	4.1%
419	Erythroplasia	4.1%
420	Follicular cyst	4.1%
421	Head and Neck Neoplasms	4.1%
422	Mucocele	4.1%
423	Pilonidal Cyst	4.1%
424	Soft Tissue Neoplasms	4.1%
425	Thoracic Neoplasms	4.1%
426	Thyroglossal Cyst	4.1%
427	Synovial Cyst	4.1%
428	Aberrant Crypt Foci	4.1%
429	Peripheral Nervous System Diseases	4.1%
430	Mitochondrial Encephalomyopathies	4.1%
431	Brain Death	4%
432	Coma, Post-Head Injury	4%
433	Prolactinoma	4%
434	Growth Hormone-Secreting Pituitary Adenoma	4%
435	Choroid Plexus Papilloma	4%
436	Dementia, Vascular	4%
437	Brain Hemorrhage, Traumatic	4%
438	Alcohol Withdrawal Seizures	4%
439	Carcinoma, Pancreatic Ductal	4%
440	Hepatolenticular Degeneration	4%
441	Reflex, Abnormal	3.9%
442	Hyporeflexia	3.9%
443	Hyperreflexia	3.9%
444	Leukemia, Myelomonocytic, Chronic	3.9%
445	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.9%
446	Posterior Leukoencephalopathy Syndrome	3.8%
447	Posterior reversible encephalopathy syndrome	3.8%
448	Friedreich Ataxia	3.8%
449	Creutzfeldt-Jakob disease	3.8%
450	Basal Ganglia Cerebrovascular Disease	3.8%
451	Carotid Artery Injuries	3.8%
452	Brain Injuries, Diffuse	3.8%
453	Traumatic Brain Injury	3.8%
454	Mesoblastic Nephroma	3.7%
455	Cerebellar Ataxia	3.7%
456	Torticollis	3.7%
457	Multiple Sclerosis, Chronic Progressive	3.7%
458	Multiple Sclerosis, Relapsing-Remitting	3.7%
459	Hepatocellular Adenoma	3.7%
460	Akathisia	3.6%
461	Restlessness	3.6%
462	Psychomotor Agitation	3.6%
463	Brain Diseases, Metabolic	3.6%
464	Cerebrovascular Disorders	3.6%
465	Optic Atrophy	3.6%
466	Optic Neuritis	3.6%
467	Papilledema	3.6%
468	Strabismus	3.6%
469	Tolosa-Hunt Syndrome	3.6%
470	Cerebrovascular Insufficiency	3.6%
471	Arsenic Poisoning	3.6%
472	Dementia	3.6%
473	Central Nervous System Fungal Infections	3.6%
474	Conus Medullaris Syndrome	3.6%
475	Spinal Cord Vascular Diseases	3.6%
476	Adenoid Cystic Carcinoma	3.6%
477	fibroma	3.6%
478	Fibromatosis	3.6%
479	Osteoblastoma	3.6%
480	Osteoma	3.6%
481	Rhabdomyoma	3.6%
482	Chondromatosis	3.6%
483	Adenocarcinoma, Clear Cell	3.6%
484	Cholangiocarcinoma	3.6%
485	Cervical Intraepithelial Neoplasia	3.6%
486	Hemangioblastoma	3.6%
487	Lymphoma, Extranodal NK-T-Cell	3.6%
488	Facial Injuries	3.6%
489	Facial Neuralgia	3.6%
490	Sleep Talking	3.6%
491	Manganese Poisoning	3.6%
492	Sleep Disorders, Intrinsic	3.6%
493	Orthostatic intolerance	3.6%
494	Muscular Dystrophy	3.6%
495	Orbital Myositis	3.6%
496	Anosmia	3.6%
497	Ataxia	3.6%
498	Athetosis	3.6%
499	Catalepsy	3.6%
500	Dystonia	3.6%
501	Hemiplegia	3.6%
502	Locked-In Syndrome	3.6%
503	Meningomyelocele	3.6%
504	Muscle Hypertonia	3.6%
505	Muscle hypotonia	3.6%
506	Myoclonus	3.6%
507	Myotonia	3.6%
508	Paraplegia	3.6%
509	Pseudobulbar Palsy	3.6%
510	Quadriplegia	3.6%
511	Spasm	3.6%
512	Spastic Paraplegia	3.6%
513	Status Epilepticus	3.6%
514	Taste Disorders	3.6%
515	Tremor	3.6%
516	Spina Bifida	3.6%
517	Monoplegia	3.6%
518	Hypokinesia	3.6%
519	Paraparesis	3.6%
520	Bradykinesia	3.6%
521	Waxy flexibility	3.6%
522	Action Tremor	3.6%
523	Resting Tremor	3.6%
524	Dysosmia	3.6%
525	Quadriparesis	3.6%
526	Mercury Poisoning, Nervous System	3.6%
527	Olfaction Disorders	3.6%
528	Myokymia	3.6%
529	Lead Poisoning, Nervous System	3.6%
530	Vestibular Neuronitis	3.6%
531	Somatosensory Disorders	3.6%
532	Hyperkinesia	3.6%
533	Intention tremor	3.6%
534	Pyomyositis	3.5%
535	Hydatidiform Mole	3.5%
536	Digestive System Neoplasms	3.4%
537	Endocrine Gland Neoplasms	3.4%
538	Eye Neoplasms	3.4%
539	Tuberculosis, Meningeal	3.4%
540	Vipoma	3.4%
541	Bone neoplasms	3.3%
542	Leukoplakia	3.3%
543	Lymphocele	3.3%
544	Pancreatic Cyst	3.3%
545	Skin Neoplasms	3.3%
546	Hematologic Neoplasms	3.3%
547	Barrett Esophagus	3.3%
548	Breast Cyst	3.3%
549	Actinic keratosis	3.3%
550	Mediastinal Cyst	3.3%
551	Neoplasm Invasiveness	3.3%
552	Neoplasm Metastasis	3.3%
553	Neoplasm Recurrence, Local	3.3%
554	Parovarian Cyst	3.3%
555	Pericardial Cyst	3.3%
556	Splenic Neoplasms	3.3%
557	Thymic Cyst	3.3%
558	Carcinogenesis	3.3%
559	Myxoid cyst	3.3%
560	Metastasis	3.3%
561	Mastocytosis	3.3%
562	Waldenstrom Macroglobulinemia	3.3%
563	Multiple Myeloma	3.3%
564	Multiple Endocrine Neoplasia Type 1	3.3%
565	Gastrointestinal Stromal Tumors	3.3%
566	Leukomalacia, Periventricular	3.2%
567	Vertebral Artery Dissection	3.2%
568	Hemangioma, Cavernous	3.2%
569	Amnesia, Transient Global	3.2%
570	Vascular Headaches	3.2%
571	Leukemia, T-Cell	3.2%
572	Leukemia, B-Cell	3.2%
573	Gait Apraxia	3.2%
574	Alice in Wonderland Syndrome	3.2%
575	Hypoxia-Ischemia, Brain	3.2%
576	Lymphoma, Follicular	3.2%
577	T-Cell Lymphoma	3.2%
578	Tardive Dyskinesia	3.2%
579	Mantle cell lymphoma	3.2%
580	Persistent Vegetative State	3.2%
581	Myoclonic Epilepsy	3.2%
582	Epilepsy, Temporal Lobe	3.2%
583	Epilepsy, Rolandic	3.2%
584	Benign Rolandic Epilepsy	3.2%
585	Vision Disorders	3.1%
586	Metamorphopsia	3.1%
587	Visual Impairment	3.1%
588	Toxoplasmosis, Cerebral	3.1%
589	Optic Neuropathy, Ischemic	3.1%
590	Anterior Ischemic Optic Neuropathy	3.1%
591	Central Nervous System Bacterial Infections	3.1%
592	Brain Concussion	3%
593	Facial Hemiatrophy	3%
594	Melkersson-Rosenthal Syndrome	3%
595	Anisocoria	3%
596	Confusion	3%
597	Facial paralysis	3%
598	Lethargy	3%
599	Memory Disorders	3%
600	Muscle Cramp	3%
601	Perceptual Disorders	3%
602	Psychomotor Disorders	3%
603	Tonic Pupil	3%
604	Anhedonia	3%
605	Disorientation	3%
606	Facial Paresis	3%
607	Memory Loss	3%
608	Hemisensory Neglect	3%
609	Dysacusis	3%
610	Sleep Bruxism	3%
611	Fibromatosis, Aggressive	3%
612	Fibromatosis, Abdominal	3%
613	Klatskin Tumor	3%
614	Hypokalemic periodic paralysis	3%
615	Anencephaly	3%
616	Meningocele	3%
617	Muscular Atrophy	3%
618	Respiratory Paralysis	3%
619	Encephalocele	3%
620	Tetany	3%
621	Mastocytoma	2.9%
622	Adenomatous Polyposis Coli	2.9%
623	Mastocytosis, Systemic	2.9%
624	Leukemia, Myeloid, Chronic-Phase	2.9%
625	Liver Neoplasms, Experimental	2.9%
626	Parathyroid Neoplasms	2.9%
627	Peritoneal Neoplasms	2.9%
628	Thyroid Neoplasm	2.9%
629	Thyroid carcinoma	2.9%
630	granulosa cell tumor	2.9%
631	Carcinoma, Ovarian Epithelial	2.9%
632	Cerebral Palsy	2.8%
633	Epilepsies, Partial	2.8%
634	Epilepsy, Generalized	2.8%
635	Pseudotumor Cerebri	2.8%
636	Hypertensive Encephalopathy	2.8%
637	Simple Partial Seizures	2.8%
638	Epilepsy, Reflex	2.8%
639	Postural Orthostatic Tachycardia Syndrome	2.8%
640	Headache Disorders, Primary	2.8%
641	Headache Disorders, Secondary	2.8%
642	Medication overuse headache	2.8%
643	Meningitis, Cryptococcal	2.8%
644	Meningitis, Listeria	2.8%
645	Meningitis, Haemophilus	2.7%
646	Meningitis, Pneumococcal	2.7%
647	Frontotemporal dementia	2.7%
648	Corpus Luteum Cyst	2.7%
649	Ovarian Cysts	2.7%
650	insulinoma	2.7%
651	Diffuse Axonal Injury	2.7%
652	Duane Retraction Syndrome	2.6%
653	Consciousness Disorders	2.6%
654	Mental Retardation	2.6%
655	Muscle Weakness	2.6%
656	Depressed Level of Consciousness	2.6%
657	Mental deficiency	2.6%
658	Intellectual Disability	2.6%
659	Mobius Syndrome	2.6%
660	Bell Palsy	2.6%
661	Giant Cell Arteritis	2.6%
662	Temporal Arteritis	2.6%
663	Catatonia	2.6%
664	Herpes Zoster Oticus	2.6%
665	Aphonia	2.6%
666	Sleep Deprivation	2.6%
667	Dysphonia	2.6%
668	Juvenile Myoclonic Epilepsy	2.5%
669	Myoclonic Epilepsies, Progressive	2.5%
670	Adrenoleukodystrophy	2.5%
671	MELAS Syndrome	2.5%
672	Pancreatic Neoplasm	2.5%
673	Auditory Perceptual Disorders	2.5%
674	Basal Ganglia Hemorrhage	2.5%
675	Retroperitoneal Neoplasms	2.4%
676	Welander Distal Myopathy	2.4%
677	Adrenocortical carcinoma	2.4%
678	Gastrinoma	2.4%
679	Glucagonoma	2.4%
680	Classical Lissencephalies and Subcortical Band Heterotopias	2.4%
681	Subarachnoid Hemorrhage, Traumatic	2.4%
682	Carotid Artery, Internal, Dissection	2.4%
683	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.4%
684	Leukemia, Large Granular Lymphocytic	2.4%
685	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.4%
686	Lymphoma, T-Cell, Cutaneous	2.4%
687	Lymphoma, AIDS-Related	2.4%
688	Enteropathy-Associated T-Cell Lymphoma	2.4%
689	Primary Effusion Lymphoma	2.4%
690	Choledochal Cyst	2.4%
691	Tracheal Neoplasms	2.4%
692	Pituitary Diseases	2.4%
693	Kearns-Sayre syndrome	2.3%
694	Peutz-Jeghers Syndrome	2.3%
695	Leukoplakia, Oral	2.3%
696	Nasopharyngeal carcinoma	2.3%
697	Pituitary Apoplexy	2.3%
698	Leydig Cell Tumor	2.3%
699	Brain Contusion	2.3%
700	Brain Infarction	2.3%
701	Subacute Sclerosing Panencephalitis	2.3%
702	Carotid Artery Diseases	2.3%
703	Brain Ischemia	2.3%
704	Esotropia	2.3%
705	Exotropia	2.3%
706	Hypotension, Orthostatic	2.3%
707	Sleep Apnea Syndromes	2.3%
708	Cerebrovascular accident	2.3%
709	Kluver-Bucy Syndrome	2.3%
710	Vasospasm, Intracranial	2.3%
711	Spinal Cord Ischemia	2.3%
712	Intracranial Arterial Diseases	2.3%
713	Post-Exercise Hypotension	2.3%
714	Disorders of Excessive Somnolence	2.3%
715	Sleep Initiation and Maintenance Disorders	2.3%
716	Night Terrors	2.3%
717	Somnambulism	2.3%
718	Trigeminal Nerve Disorder	2.3%
719	Transient Insomnia	2.3%
720	Sleep Paralysis	2.3%
721	Chronic Insomnia	2.3%
722	REM Sleep Behavior Disorder	2.3%
723	Hypersomnia	2.3%
724	Dermal Sinus	2.2%
725	Dysgeusia	2.2%
726	Formication	2.2%
727	Hyperalgesia	2.2%
728	Hyperesthesia	2.2%
729	Hypesthesia	2.2%
730	Language Disorders	2.2%
731	Numbness	2.2%
732	Paresthesia	2.2%
733	Paraparesis, Spastic	2.2%
734	Spina Bifida Cystica	2.2%
735	Trismus	2.2%
736	Spina Bifida Occulta	2.2%
737	Epilepsia Partialis Continua	2.2%
738	Hypogeusia	2.2%
739	Brown-Sequard Syndrome	2.2%
740	Lissencephaly	2.2%
741	Polymicrogyria	2.2%
742	Pachygyria	2.2%
743	Schizencephaly	2.2%
744	Lockjaw	2.2%
745	Allodynia	2.2%
746	Lead Poisoning, Nervous System, Childhood	2.2%
747	Lead Poisoning, Nervous System, Adult	2.2%
748	Periventricular Nodular Heterotopia	2.2%
749	Ageusia	2.2%
750	Tuberculosis, Central Nervous System	2.2%
751	Neuronal Ceroid-Lipofuscinoses	2.2%
752	Denys-Drash Syndrome	2.2%
753	Renal Cell Carcinoma	2.1%
754	Papillary Renal Cell Carcinoma	2.1%
755	Dermatomyositis	2.1%
756	Muscular Dystrophy, Duchenne	2.1%
757	Dupuytren Contracture	2%
758	Esophageal Neoplasms	2%
759	Carcinoma, Endometrioid	2%
760	Aicardi's syndrome	2%
761	Putaminal Hemorrhage	2%
762	Hoarseness	2%
763	Urticaria Pigmentosa	2%
764	Cockayne Syndrome	2%
765	Alexia	2%
766	Post-Traumatic Headache	2%
767	Tension Headache	2%
768	Epilepsy, Complex Partial	2%
769	Migraine Disorders	2%
770	Abdominal Migraine	2%
771	Status Migrainosus	2%
772	Cervicogenic Headache	2%
773	Dyslexia	2%
774	Alcohol Withdrawal Delirium	2%
775	Mycosis Fungoides	2%
776	Lymphomatoid Papulosis	2%
777	Plasmablastic lymphoma	2%
778	Mouth Neoplasms	2%
779	Vascular Neoplasms	2%
780	Thymus Neoplasms	2%
781	Hematoma, Subdural	2%
782	Hematoma, Epidural, Cranial	2%
783	Genital Neoplasms, Female	2%
784	Pancreatic Pseudocyst	2%
785	Eye Injuries	1.9%
786	Lymphatic Metastasis	1.9%
787	Neoplasms, Unknown Primary	1.9%
788	Leukemic Infiltration	1.9%
789	Breast Neoplasms, Male	1.9%
790	Optic Atrophy, Hereditary, Leber	1.9%
791	Neoplasm Micrometastasis	1.9%
792	Triple Negative Breast Neoplasms	1.9%
793	Infarction, Middle Cerebral Artery	1.9%
794	Infarction, Anterior Cerebral Artery	1.9%
795	Infarction, Posterior Cerebral Artery	1.9%
796	Congenital nystagmus	1.9%
797	Diplopia	1.9%
798	Muscle Rigidity	1.9%
799	Muscle Spasticity	1.9%
800	Scotoma	1.9%
801	Photophobia	1.9%
802	Cogwheel Rigidity	1.9%
803	Hemifacial Spasm	1.9%
804	Amaurosis	1.9%
805	Blindness	1.9%
806	Nuchal Rigidity	1.9%
807	Reye Syndrome	1.9%
808	Neuroaspergillosis	1.9%
809	Intracranial Embolism and Thrombosis	1.9%
810	Hepatic Encephalopathy	1.9%
811	Agnosia	1.9%
812	Apraxias	1.9%
813	Hallucinations	1.9%
814	Hemianopsia	1.9%
815	Hyperacusis	1.9%
816	Tinnitus	1.9%
817	Visual Agnosia	1.9%
818	Anosognosia	1.9%
819	Wernicke-Korsakoff Syndrome	1.9%
820	Phonophobia	1.9%
821	Hearing Loss	1.9%
822	Sarcopenia	1.9%
823	Thyroid Nodule	1.9%
824	Testicular Neoplasms	1.8%
825	Cerebral Infarction	1.8%
826	Brain Stem Infarctions	1.8%
827	Moyamoya Disease	1.8%
828	Burkitt Lymphoma	1.8%
829	Holoprosencephaly	1.8%
830	Pseudorabies	1.7%
831	West Nile Fever	1.7%
832	Adrenal Gland Neoplasms	1.7%
833	Gastrointestinal Neoplasms	1.7%
834	Genital Neoplasms, Male	1.7%
835	Liver neoplasms	1.7%
836	Uveal Neoplasms	1.7%
837	Urologic Neoplasms	1.7%
838	Amnesia	1.6%
839	Delirium	1.6%
840	Dissociative Amnesia	1.6%
841	Color blindness	1.6%
842	Global Amnesia	1.6%
843	Sebaceous Gland Neoplasms	1.6%
844	Spinal Neoplasms	1.6%
845	Bone Marrow Neoplasms	1.6%
846	Empty Sella Syndrome	1.6%
847	Hyperpituitarism	1.6%
848	Hypopituitarism	1.6%
849	Hypophysitis	1.6%
850	Cri-du-Chat Syndrome	1.6%
851	Down Syndrome	1.6%
852	Brain Diseases, Metabolic, Inborn	1.6%
853	Trisomy 21	1.6%
854	Williams Syndrome	1.6%
855	Microcephaly	1.6%
856	Macrocephaly	1.6%
857	Polycystic Ovary Syndrome	1.6%
858	Neurosyphilis	1.6%
859	neurofibroma	1.6%
860	Cerebral Arterial Diseases	1.6%
861	Vertebrobasilar Insufficiency	1.6%
862	Anterior Spinal Artery Syndrome	1.6%
863	Basilar Artery Stenosis	1.6%
864	Vertebral Artery Stenosis	1.6%
865	Sleep Apnea, Obstructive	1.6%
866	Sleep Apnea, Central	1.6%
867	Intracranial Hemorrhage, Hypertensive	1.6%
868	Transient Cerebral Ischemia	1.6%
869	Porencephaly	1.6%
870	Narcolepsy	1.6%
871	Trigeminal Neuralgia	1.6%
872	Kleine-Levin Syndrome	1.6%
873	Cluster Headache	1.6%
874	Migraine with Aura	1.6%
875	Familial Hemiplegic Migraine	1.6%
876	Chronic Paroxysmal Hemicrania	1.6%
877	SUNCT Syndrome	1.6%
878	Paroxysmal Hemicrania	1.6%
879	Agraphia	1.6%
880	Anomia	1.6%
881	Cluttering	1.6%
882	Language Development Disorders	1.6%
883	Speech Disorders	1.6%
884	Syncope	1.6%
885	Stupor	1.6%
886	Dysgraphia	1.6%
887	Presyncope	1.6%
888	Dyslalia	1.6%
889	Lateral Medullary Syndrome	1.6%
890	Xeroderma Pigmentosum	1.5%
891	Sezary Syndrome	1.5%
892	Hematoma, Subdural, Intracranial	1.5%
893	Hematoma, Subdural, Chronic	1.5%
894	Hematoma, Subdural, Acute	1.5%
895	Nelson Syndrome	1.5%
896	Prader-Willi Syndrome	1.4%
897	Wernicke Encephalopathy	1.4%
898	AIDS Dementia Complex	1.4%
899	Phantom pain	1.4%
900	Phantom Limb Pain	1.4%
901	Lyme Neuroborreliosis	1.4%
902	Toxoplasmosis, Congenital	1.4%
903	Eye Burns	1.4%
904	Malaria, Cerebral	1.4%
905	Carotid Stenosis	1.3%
906	Intracranial Aneurysm	1.3%
907	Neurocysticercosis	1.3%
908	Nose Neoplasms	1.3%
909	Amaurosis Fugax	1.3%
910	Blindness, Cortical	1.3%
911	Dyscalculia	1.3%
912	Intracranial Arteriosclerosis	1.3%
913	Cerebral Atherosclerosis	1.3%
914	Rett Syndrome	1.3%
915	Subarachnoid Hemorrhage	1.3%
916	Cerebral Arteriosclerosis	1.3%
917	Cerebral Hemorrhage	1.3%
918	Cerebral Thrombosis	1.3%
919	Intracranial Embolism	1.3%
920	Intracranial Thrombosis	1.3%
921	Deafness	1.3%
922	Hearing Loss, Sudden	1.3%
923	Gerstmann Syndrome	1.3%
924	Hearing Loss, Bilateral	1.3%
925	Hearing Loss, High-Frequency	1.3%
926	Hearing Loss, Mixed Conductive-Sensorineural	1.3%
927	Prosopagnosia	1.3%
928	Apraxia, Ideomotor	1.3%
929	Charles Bonnet Syndrome	1.3%
930	Hearing Loss, Unilateral	1.3%
931	Complete Hearing Loss	1.3%
932	Alien Hand Syndrome	1.3%
933	Deaf Mutism	1.3%
934	Hyperprolactinemia	1.3%
935	Kernicterus	1.3%
936	Subclavian Steal Syndrome	1.3%
937	Pick Disease of the Brain	1.3%
938	Cataplexy	1.3%
939	Aphasia	1.3%
940	Articulation Disorders	1.3%
941	Echolalia	1.3%
942	Stuttering	1.3%
943	Dysphasia	1.3%
944	Palatal Neoplasms	1.3%
945	Menkes Kinky Hair Syndrome	1.2%
946	ovarian neoplasm	1.2%
947	Waterhouse-Friderichsen Syndrome	1.2%
948	Corneal Scar	1.2%
949	Retrograde amnesia	1.1%
950	Amnesia, Anterograde	1.1%
951	Carotid Artery Thrombosis	1.1%
952	Rubinstein-Taybi Syndrome	1.1%
953	Dysarthria	1.1%
954	Ear Neoplasms	1.1%
955	Eyelid Neoplasms	1.1%
956	Lung Neoplasms	1.1%
957	Pleural Neoplasms	1.1%
958	Cell Transformation, Viral	1.1%
959	Salivary Gland Neoplasms	1.1%
960	Tongue Neoplasms	1.1%
961	Mutism	1.1%
962	Selective Mutism	1.1%
963	Acromegaly	1.1%
964	Uterine Neoplasms	1.1%
965	Vaginal Neoplasms	1.1%
966	Vulvar Neoplasms	1.1%
967	Uterine Cancer	1.1%
968	Fallopian Tube Neoplasms	1.1%
969	Cerebral Amyloid Angiopathy	1.1%
970	Sinus Thrombosis, Intracranial	1.1%
971	Fragile X Syndrome	1%
972	Zollinger-Ellison syndrome	1%
973	Pharyngeal Neoplasms	1%
974	Alexia, Pure	0.9%
975	Bile Duct Neoplasms	0.9%
976	gallbladder neoplasm	0.9%
977	Intestinal Neoplasms	0.9%
978	Penile Neoplasms	0.9%
979	Prostatic Neoplasms	0.9%
980	Stomach Neoplasms	0.9%
981	Cavernous Sinus Thrombosis	0.9%
982	Sagittal Sinus Thrombosis	0.9%
983	Corneal Perforation	0.9%
984	Polycythemia Vera	0.9%
985	Fabry Disease	0.9%
986	Galactosemias	0.9%
987	Urea Cycle Disorders, Inborn	0.9%
988	Tyrosinemias	0.9%
989	Laryngeal neoplasm	0.8%
990	Bronchial Neoplasms	0.8%
991	Bladder Neoplasm	0.8%
992	Kidney Neoplasm	0.8%
993	Ureteral Neoplasms	0.8%
994	Urethral Neoplasms	0.8%
995	Multiple Pulmonary Nodules	0.8%
996	Homocystinuria	0.8%
997	Leigh Disease	0.8%
998	Endometrial Neoplasms	0.8%
999	Mucopolysaccharidosis II	0.7%
1000	Hypopharyngeal Neoplasms	0.7%
1001	Pleural Effusion, Malignant	0.7%
1002	Hypopharyngeal Cancer	0.7%
1003	Parotid Neoplasms	0.7%
1004	Prostatic Neoplasms, Castration-Resistant	0.7%
1005	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.6%
1006	Zellweger Syndrome	0.6%
1007	Cecal Neoplasms	0.6%
1008	Duodenal Neoplasms	0.6%
1009	Glycogen storage disease type II	0.6%
1010	Tonsillar Neoplasms	0.6%
1011	Nasopharyngeal Neoplasms	0.5%
1012	Colorectal Neoplasms	0.5%
1013	Radicular Cyst	0.5%
1014	Appendiceal Neoplasms	0.5%
1015	Colonic Neoplasms	0.5%
1016	Rectal Neoplasms	0.5%
1017	Paranasal Sinus Neoplasms	0.5%
1018	Gaucher Disease	0.5%
1019	Tay-Sachs Disease	0.4%
1020	Maxillary Sinus Neoplasms	0.4%
1021	Anus Neoplasms	0.4%
1022	Sigmoid Neoplasms	0.4%
1023	Niemann-Pick Disease, Type C	0.4%

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