MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Discitis

(UMLS:C0012624)

Definition:: Inflammation of an INTERVERTEBRAL DISC or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.
UMLS ID:: C0012624
MeSH ID:: D015299

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.539.160.762.301

Classification 2:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.165.762.301|C05.116.900.853.500

Synonym(s)

Discitis

Discitis, NOS

Discitis, unspecified

Intervertebral discitis

discitis

discitis, diskitis

diskitis

spondylodiscitis

spondylodiskitis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Diclofenac	9654706	CTD
2	Fosfomycin	8786835	CTD
3	Minocycline	8786835	CTD
4	Ofloxacin	19718264	CTD
5	Rifampin	19718264	CTD
6	Trimethoprim, Sulfamethoxazole Drug Combination	19718264	CTD
7	Vancomycin	8786835 19718264	CTD
8	arbekacin	8786835	CTD
9	flomoxef	8786835	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Osteomyelitis	33.3%
2	Periostitis	33.3%
3	Tuberculosis, Spinal	32.6%
4	Joint Tuberculosis	28.3%
5	Tuberculosis, Osteoarticular	28.3%
6	Bone Tuberculosis	28.3%
7	Osteoarthropathy, Secondary Hypertrophic	26.8%
8	Spinal Neoplasms	26.2%
9	Platybasia	25.2%
10	Bone Diseases, Developmental	24.8%
11	Hyperostosis	24.8%
12	Osteitis	24.8%
13	Osteitis Deformans	24.8%
14	Osteochondrosis	24.8%
15	Spinal Stenosis	24.4%
16	Spondylosis	24.4%
17	Intervertebral Disc Degeneration	24.4%
18	Osteochondritis	22.3%
19	Bone Diseases, Endocrine	20.7%
20	Bone neoplasms	20.1%
21	Osteopenia	20.1%
22	Spondylarthropathies	19.9%
23	Bone Resorption	19.9%
24	Aseptic Necrosis of Bone	19.9%
25	Gigantism	19.7%
26	Osteoarthritis, Spine	18.9%
27	Mastoiditis	18.3%
28	Petrositis	18.3%
29	Arthritis, Reactive	17.7%
30	Ankylosing spondylitis	16.9%
31	Lordosis	16.1%
32	Spondylolysis	16.1%
33	kyphosis	16.1%
34	Pectus carinatum	15.9%
35	Pectus excavatum	15.5%
36	Fasciitis	15.4%
37	Foot Deformities	15.4%
38	Arthropathy	15.4%
39	Ainhum	14.6%
40	Dysostoses	14.6%
41	Arthritis, Psoriatic	14.5%
42	Arthrogryposis	14.5%
43	Arthritis, Infectious	13.9%
44	Contracture	13.4%
45	Fasciitis, Plantar	13.4%
46	Jaw Diseases	12.8%
47	Cartilage Diseases	12.4%
48	Foot Diseases	12.4%
49	Myopathy	12.4%
50	Rheumatism	12.4%
51	Chondromalacia	12.4%
52	Congenital Hypothyroidism	12.4%
53	Pelvic Infection	12.4%
54	Spinal Diseases	12.4%
55	Wound Infection	12.4%
56	Soft Tissue Infection	12.4%
57	Community-Acquired Infections	12.4%
58	Eosinophilic Granuloma	12.3%
59	Klippel-Feil Syndrome	12.1%
60	Synostosis	12.1%
61	Spondylolisthesis	12%
62	Multiple Epiphyseal Dysplasia	11.9%
63	Osteochondrodysplasias	11.9%
64	Osteoporosis	11.8%
65	Bone Demineralization, Pathologic	11.8%
66	Post-Traumatic Osteoporosis	11.8%
67	Alveolar Bone Loss	11.7%
68	Femur Head Necrosis	11.7%
69	Osteolysis	11.7%
70	Fibromyalgia	11.2%
71	Polymyalgia Rheumatica	11.2%
72	Metatarsalgia	11.1%
73	Eye Infection	10.3%
74	Respiratory Tract Infections	10.3%
75	Dwarfism	10.3%
76	Bone Diseases, Infectious	10.1%
77	Pregnancy Complications, Infectious	10.1%
78	Skin Diseases, Infectious	10.1%
79	Suppuration	9.9%
80	Rheumatic Fever	9.9%
81	Cross Infection	9.9%
82	Septicemia	9.9%
83	Sepsis	9.9%
84	Spondylitis	9.8%
85	Acromegaly	9.7%
86	Craniofacial Dysostosis	9.7%
87	Chondrodysplasia Punctata	9.7%
88	Enchondromatosis	9.7%
89	Osteosclerosis	9.7%
90	Kashin-Beck Disease	9.7%
91	Gout	9.1%
92	Ulcerative stomatitis	9%
93	Opportunistic Infections	8.9%
94	Craniosynostosis	8.5%
95	Syndactyly	8.5%
96	Brachycephaly	8.5%
97	Cellulitis	8.5%
98	Ischemic contracture	8.5%
99	Temporomandibular Joint Disorders	8.4%
100	Rickets	8.4%
101	Urinary tract infection	8.4%
102	Arthritis	8.3%
103	Bursitis	8.3%
104	Joint Instability	8.3%
105	Myofascial Pain Syndromes	8.3%
106	Rhabdomyolysis	8.3%
107	Synovitis	8.3%
108	Joint laxity	8.3%
109	Polyarthritis	8.3%
110	Frozen shoulder	8.3%
111	Patellofemoral Pain Syndrome	8.3%
112	Pyomyositis	8.2%
113	Endotoxemia	8.1%
114	Hip Contracture	7.8%
115	Periarthritis	7.8%
116	Osteoporosis, Postmenopausal	7.7%
117	Dermatomycoses	7.7%
118	Skin Diseases, Bacterial	7.7%
119	Bacterial Infections	7.7%
120	Mycoses	7.7%
121	Bacteremia	7.7%
122	Rheumatoid Arthritis	7.7%
123	Juvenile arthritis	7.7%
124	Acrocephalosyndactylia	7.6%
125	Sexually Transmitted Diseases	7.4%
126	Pseudohypoparathyroidism	7.3%
127	Hidradenitis Suppurativa	7.3%
128	Melorheostosis	7.2%
129	Osteopetrosis	7.2%
130	Talipes	6.9%
131	Temporomandibular Joint Dysfunction Syndrome	6.9%
132	Compartment syndromes	6.7%
133	Maxillary Diseases	6.7%
134	Tendinitis	6.7%
135	Tendinopathy	6.7%
136	Bacterial Endocarditis	6.7%
137	Hemarthrosis	6.6%
138	Myositis	6.6%
139	Tietze's Syndrome	6.6%
140	Limb Deformities, Congenital	6.6%
141	Isaacs syndrome	6.6%
142	Craniofacial Abnormalities	6.6%
143	Myotonic Disorders	6.6%
144	Osteogenesis Imperfecta	6.6%
145	Fungemia	6.5%
146	Osteoarthritis, Knee	6.5%
147	Discitis	6.5%
148	Mycetoma	6.3%
149	Central Nervous System Infection	6.2%
150	Poland Syndrome	6.2%
151	Antley-Bixler Syndrome Phenotype	6.1%
152	Pertussis	6%
153	Marfan Syndrome	6%
154	Mandibulofacial Dysostosis	6%
155	Basal Cell Nevus Syndrome	6%
156	Endophthalmitis	6%
157	Peritonitis	6%
158	Rubinstein-Taybi Syndrome	5.9%
159	Surgical Wound Infection	5.9%
160	Abscess	5.8%
161	Adnexitis	5.8%
162	Empyema	5.8%
163	Pelvic Inflammatory Disease	5.8%
164	Arthritis, Gouty	5.6%
165	Central Nervous System Bacterial Infections	5.6%
166	Medial Tibial Stress Syndrome	5.6%
167	Goldenhar Syndrome	5.6%
168	Candidiasis, Chronic Mucocutaneous	5.6%
169	Cutaneous Candidiasis	5.6%
170	Mitochondrial Myopathies	5.5%
171	Osteomalacia	5.5%
172	Muscle Cramp	5.5%
173	Eosinophilia-Myalgia Syndrome	5.5%
174	Gastroschisis	5.5%
175	Muscle Rigidity	5.4%
176	Muscle Spasticity	5.4%
177	Cogwheel Rigidity	5.4%
178	Nuchal Rigidity	5.4%
179	Palatal Neoplasms	5.4%
180	Rheumatoid Nodule	5.4%
181	Brain Abscess	5.2%
182	Jaw Abnormalities	5.1%
183	Erysipelas	5.1%
184	Staphylococcal Skin Infections	5.1%
185	Superinfection	5%
186	Corneal Ulcer	5%
187	Chronic Fatigue Syndrome	4.9%
188	Puerperal Infection	4.9%
189	Appendicitis	4.9%
190	Bacteriuria	4.9%
191	Pyuria	4.9%
192	Bunion	4.9%
193	Fibrodysplasia Ossificans Progressiva	4.9%
194	Myoglobinuria	4.9%
195	Myositis Ossificans	4.9%
196	Tenosynovitis	4.9%
197	Sacroiliitis	4.9%
198	Chromoblastomycosis	4.9%
199	Dermatophytosis	4.9%
200	Sporotrichosis	4.9%
201	Tinea	4.9%
202	Tinea Versicolor	4.9%
203	Trichophytosis	4.9%
204	Hyalohyphomycosis	4.9%
205	Endotoxic shock	4.9%
206	Septic Shock	4.9%
207	Toxic Shock Syndrome	4.9%
208	Erythrasma	4.8%
209	Psoas Abscess	4.8%
210	Abdominal Abscess	4.8%
211	Candidemia	4.8%
212	Congenital clubfoot	4.8%
213	Vertical Talus	4.8%
214	Nail-Patella Syndrome	4.8%
215	Giant Cell Epulis	4.8%
216	Muscle Weakness	4.8%
217	Musculoskeletal Pain	4.7%
218	Familial Periodic Paralysis	4.7%
219	Arthralgia	4.7%
220	Polyarthralgia	4.7%
221	Syphilis	4.7%
222	Felty Syndrome	4.7%
223	Ecthyma	4.5%
224	Subacute Bacterial Endocarditis	4.5%
225	Chlamydia Infections	4.4%
226	Gonorrhea	4.4%
227	Prognathism	4.4%
228	Cockayne Syndrome	4.4%
229	Blastomycosis	4.4%
230	Erythema Chronicum Migrans	4.4%
231	Hordeolum	4.2%
232	Laryngomalacia	4.2%
233	Bacterial conjunctivitis	4.2%
234	Panophthalmitis	4.2%
235	Aspergillosis	4.1%
236	Candidiasis	4.1%
237	Coccidioidomycosis	4.1%
238	Histoplasmosis	4.1%
239	Paracoccidioidomycosis	4.1%
240	Zygomycosis	4.1%
241	Gram-Negative Bacterial Infections	4.1%
242	Gram-Positive Bacterial Infections	4.1%
243	Phaeohyphomycosis	4.1%
244	Pneumocystis Infections	4.1%
245	Myalgia	4.1%
246	Rheumatoid Vasculitis	4.1%
247	Nose Neoplasms	4%
248	Impetigo	4%
249	Anterior Compartment Syndrome	3.9%
250	Borrelia Infections	3.9%
251	Leptospirosis	3.9%
252	Enthesopathy	3.9%
253	Arthritis, Experimental	3.9%
254	Abdominal Compartment Syndrome	3.9%
255	Amelia	3.9%
256	Arachnodactyly	3.9%
257	Ectromelia	3.9%
258	Hemimelia	3.9%
259	Phocomelia	3.9%
260	Sirenomelia	3.9%
261	Polymyositis	3.9%
262	Polydactyly	3.9%
263	Brachydactyly	3.9%
264	Plagiocephaly	3.9%
265	Lower Extremity Deformities, Congenital	3.9%
266	Upper Extremity Deformities, Congenital	3.9%
267	Renal Osteodystrophy	3.9%
268	Renal rickets	3.9%
269	Diverticulitis	3.9%
270	AIDS-Related Opportunistic Infections	3.7%
271	Staphylococcal Scalded Skin Syndrome	3.7%
272	Sicca Syndrome	3.6%
273	Sjogren's Syndrome	3.6%
274	Rhinoscleroma	3.5%
275	Fusariosis	3.5%
276	Otomycosis	3.4%
277	Hip Dislocation	3.4%
278	Shoulder Dislocation	3.4%
279	Hip Dysplasia	3.4%
280	Lung Abscess	3.3%
281	Piedra	3.3%
282	Central Nervous System Fungal Infections	3.3%
283	Muscular Dystrophy	3.3%
284	Orbital Myositis	3.3%
285	Dupuytren Contracture	3.3%
286	Diverticulum	3.3%
287	Bacterial Vaginosis	3.3%
288	Diverticulosis	3.3%
289	Myotonic Dystrophy	3.3%
290	Neuroaspergillosis	3.3%
291	Furunculosis	3.2%
292	furuncle	3.2%
293	Micrognathism	3.2%
294	Pierre Robin Syndrome	3.2%
295	Lyme Disease	3.2%
296	Relapsing Fever	3.2%
297	Lymphogranuloma Venereum	3.2%
298	Lyme Neuroborreliosis	3%
299	Tinea Capitis	3%
300	Onychomycosis	3%
301	carbuncle	3%
302	Liver Abscess	3%
303	Retrognathia	2.9%
304	Ophthalmia Neonatorum	2.9%
305	Trachoma	2.9%
306	Maxillofacial Abnormalities	2.8%
307	Lung Diseases, Fungal	2.8%
308	Myotonia Congenita	2.8%
309	Retropharyngeal Abscess	2.8%
310	Bronchomalacia	2.8%
311	Epidural Abscess	2.8%
312	Tracheomalacia	2.8%
313	Microcephaly	2.8%
314	Macrocephaly	2.8%
315	Neurosyphilis	2.8%
316	Peritonsillar Abscess	2.8%
317	Hypokalemic periodic paralysis	2.8%
318	Pneumonia, Bacterial	2.8%
319	Shoulder Pain	2.8%
320	Invasive Pulmonary Aspergillosis	2.7%
321	Tinea Pedis	2.6%
322	Human Ehrlichiosis	2.6%
323	Erythema Induratum	2.5%
324	Actinomycetales Infections	2.4%
325	Bordetella Infections	2.4%
326	Brucellosis	2.4%
327	Campylobacter infection	2.4%
328	Clostridium Infections	2.4%
329	Enterobacteriaceae Infections	2.4%
330	Listeriosis	2.4%
331	Mucormycosis	2.4%
332	Pseudomonas Infections	2.4%
333	Q Fever	2.4%
334	Staphylococcal Infections	2.4%
335	Streptococcal Infections	2.4%
336	Vibrio Infections	2.4%
337	Helicobacter Infections	2.4%
338	Bacillaceae Infections	2.4%
339	Neisseriaceae Infections	2.4%
340	Mitochondrial Encephalomyopathies	2.4%
341	Burkholderia Infections	2.4%
342	Clostridium difficile infection	2.4%
343	Flavobacteriaceae Infections	2.4%
344	Moraxellaceae Infections	2.4%
345	Burkholderia cepacia Infection	2.4%
346	Cleft Palate	2.4%
347	Toxoplasmosis, Cerebral	2.4%
348	Meningitis, Cryptococcal	2.3%
349	Japanese Spotted Fever	2.3%
350	Human anaplasmosis	2.2%
351	Noonan Syndrome	2.2%
352	Welander Distal Myopathy	2.2%
353	Erysipelothrix infection	2%
354	Oral candidiasis	2%
355	Holoprosencephaly	2%
356	Pulmonary Aspergillosis	2%
357	Bronchopulmonary Aspergillosis	2%
358	Familial Hypophosphatemic Rickets	1.9%
359	Dermatomyositis	1.9%
360	Muscular Dystrophy, Duchenne	1.9%
361	Meningitis, Listeria	1.8%
362	Porencephaly	1.8%
363	Rocky Mountain Spotted Fever	1.8%
364	Syphilis, Congenital	1.6%
365	Meningitis, Bacterial	1.6%
366	Meningitis, Fungal	1.6%
367	Acinetobacter Infections	1.6%
368	Actinomycosis	1.6%
369	Bacteroides Infections	1.6%
370	Cholera	1.6%
371	Corynebacterium Infections	1.6%
372	Escherichia coli Infections	1.6%
373	Gas Gangrene	1.6%
374	Haemophilus Infections	1.6%
375	Klebsiella Infections	1.6%
376	Meningococcal Infections	1.6%
377	Mycobacterium Infections	1.6%
378	Mycoplasma Infections	1.6%
379	Nocardia Infections	1.6%
380	Pasteurella Infections	1.6%
381	Pneumococcal Infections	1.6%
382	Proteus Infections	1.6%
383	Rickettsia Infections	1.6%
384	Salmonella infections	1.6%
385	Scarlet Fever	1.6%
386	Scrub Typhus	1.6%
387	Tetanus	1.6%
388	Serratia Infections	1.6%
389	Ureaplasma Infections	1.6%
390	Pulmonary Nocardiosis	1.6%
391	Candidiasis, Vulvovaginal	1.6%
392	Meningitis, Haemophilus	1.6%
393	Meningitis, Pneumococcal	1.6%
394	Liver Abscess, Amebic	1.5%
395	Tuberculosis, Meningeal	1.3%
396	Radicular Cyst	1.2%
397	Diphtheria	1.2%
398	Leprosy	1.2%
399	Mycobacterium Infections, Nontuberculous	1.2%
400	Psittacosis	1.2%
401	Paratyphoid Fever	1.2%
402	Plague	1.2%
403	Tuberculosis	1.2%
404	Typhoid Fever	1.2%
405	TYPHUS	1.2%
406	Yersinia pseudotuberculosis Infections	1.2%
407	Bubonic Plague	1.2%
408	Mycobacterium abscessus Infection	1.2%
409	Enterocolitis, Pseudomembranous	1.1%
410	pseudomembranous colitis	1.1%
411	Dysentery, Bacillary	1.1%
412	MELAS Syndrome	1.1%
413	Salmonella Infections, Animal	1%
414	Mycobacterium avium-intracellulare Infection	1%
415	Lymph Node Tuberculosis	1%
416	Tuberculosis, Miliary	1%
417	Tuberculosis, Multidrug-Resistant	1%
418	Leprosy, Multibacillary	1%
419	Latent Tuberculosis	1%
420	Kearns-Sayre syndrome	1%
421	Rheumatic Heart Disease	1%
422	Salmonella food poisoning	1%
423	Botulism	0.9%
424	Borderline leprosy	0.9%
425	Leprosy, Lepromatous	0.9%
426	Tuberculoid leprosy	0.9%
427	Extensively Drug-Resistant Tuberculosis	0.9%
428	Aspergillosis, Allergic Bronchopulmonary	0.8%
429	Tuberculosis, Gastrointestinal	0.8%
430	Tuberculosis, Central Nervous System	0.8%
431	Waterhouse-Friderichsen Syndrome	0.7%
432	Tuberculosis, Pulmonary	0.7%
433	Lemierre Syndrome	0.5%
434	Tuberculosis, Renal	0.5%

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