MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Alexander Disease

(UMLS:C0270726)

Definition:: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
UMLS ID:: C0270726
MeSH ID:: D038261

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.362.312|C10.228.140.695.625.312|C10.314.400.312|C10.574.500.024

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.400.024|C16.320.565.189.362.312

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.362.312|C18.452.648.189.362.312

Synonym(s)

Alexander Disease

ALEXANDER DISEASE

Alexander disease

Alexander syndrome

Alexander's disease

Fibrinoid leukodystrophy

Progressive astrocyte degeneration syndrome

alexander disease

alexander's disease

10.

alexanders disease

11.

demyelinogenic leukodystrophy

12.

dysmyelinogenic leukodystrophy

13.

fibrinoid degeneration of astrocytes

14.

fibrinoid leukodystrophy

15.

macrocephaly with feeblemindedness and encephalopathy with peculiar deposits

16.

megalencephaly with hyaline panneuropathy

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Vigabatrin		10802771	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Canavan Disease	60.1%
2	Adrenoleukodystrophy	57.2%
3	Hepatolenticular Degeneration	47.1%
4	Refsum Disease	39.3%
5	Menkes Kinky Hair Syndrome	36%
6	Galactosemias	35.8%
7	Urea Cycle Disorders, Inborn	35.8%
8	Tyrosinemias	35.8%
9	Leigh Disease	34.4%
10	Homocystinuria	31.4%
11	Dystonia Musculorum Deformans	30.2%
12	Zellweger Syndrome	29.2%
13	Huntington Disease	28.8%
14	MELAS Syndrome	28.5%
15	Myelinolysis, Central Pontine	27.6%
16	Amyloid Neuropathies, Familial	27.5%
17	Glycogen storage disease type II	26.6%
18	Cockayne Syndrome	26.4%
19	Carbamoyl-Phosphate Synthase I Deficiency Disease	26.4%
20	Neuronal Ceroid-Lipofuscinoses	26.3%
21	Lafora Disease	25.5%
22	Unverricht-Lundborg Syndrome	25.5%
23	Multiple System Atrophy	25.4%
24	Friedreich Ataxia	24.5%
25	Tuberous Sclerosis	24.4%
26	Fabry Disease	23.5%
27	Myotonic Dystrophy	23.3%
28	Meningoencephalitis	22.7%
29	Subacute Combined Degeneration	22.5%
30	Lewy Body Disease	22.4%
31	Marchiafava-Bignami Disease	22.2%
32	Myotonia Congenita	22%
33	Alstrom Syndrome	21.7%
34	Dementia, Vascular	21.7%
35	Amyotrophic Lateral Sclerosis	21.4%
36	Dandy-Walker Syndrome	21.1%
37	Gaucher Disease	20.7%
38	Leukoencephalitis, Acute Hemorrhagic	20.5%
39	Leukoencephalopathy, Progressive Multifocal	20%
40	Encephalomyelitis	19.8%
41	Pneumocephalus	19.6%
42	Smith-Lemli-Opitz Syndrome	19.5%
43	Mitochondrial Encephalomyopathies	19.5%
44	Mucopolysaccharidosis II	19%
45	Parkinson Disease	19%
46	Charcot-Marie-Tooth Disease	19%
47	Ataxia Telangiectasia	18.9%
48	Optic Atrophy, Hereditary, Leber	18.9%
49	Progressive supranuclear palsy	18.6%
50	Ophthalmoplegic Migraine	18.4%
51	Ocular Motility Disorders	18%
52	Cyclophoria	18%
53	Prion Diseases	18%
54	Subdural Effusion	18%
55	Reye Syndrome	17.8%
56	Hepatic Encephalopathy	17.7%
57	Amino Acid Metabolism, Inborn Errors	17.7%
58	Carbohydrate Metabolism, Inborn Errors	17.7%
59	Metal Metabolism, Inborn Errors	17.7%
60	Progeria	17.7%
61	Lysosomal Storage Diseases	17.7%
62	Peroxisomal Disorders	17.7%
63	Motor Neuron Disease	17.6%
64	Posterior Leukoencephalopathy Syndrome	17.6%
65	Posterior reversible encephalopathy syndrome	17.6%
66	Stiff-Person Syndrome	17.5%
67	Brain Abscess	17.3%
68	Polyradiculoneuropathy	17.1%
69	Polyradiculoneuritis	17.1%
70	Myelitis, Transverse	16.8%
71	Hyperphosphaturia	16.8%
72	Niemann-Pick Disease, Type C	16.7%
73	Spinal Muscular Atrophy	16.5%
74	Progressive Muscular Atrophy	16.5%
75	Striatonigral Degeneration	16.4%
76	Tay-Sachs Disease	16.2%
77	Ichthyosis, X-Linked	16.2%
78	Pseudohypoparathyroidism	16.1%
79	Albinism	16%
80	Brain Injuries	16%
81	Brain Neoplasms	15.9%
82	Epilepsy, Post-Traumatic	15.9%
83	Epidural Abscess	15.9%
84	Encephalomyelitis, Acute Disseminated	15.9%
85	Fragile X Syndrome	15.8%
86	Aicardi's syndrome	15.7%
87	Kernicterus	15.6%
88	Leukomalacia, Periventricular	15.4%
89	Miller Fisher Syndrome	15.4%
90	Parkinsonian Disorders	15.4%
91	Wernicke Encephalopathy	15.4%
92	Werner Syndrome	15.2%
93	Shy-Drager Syndrome	15.2%
94	Limbic Encephalitis	15%
95	Basal Ganglia Cerebrovascular Disease	14.9%
96	Akinetic Mutism	14.9%
97	Anoxic Encephalopathy	14.9%
98	Basal Ganglia Diseases	14.9%
99	Brain Damage, Chronic	14.9%
100	Cerebellar Diseases	14.9%
101	Encephalitis	14.9%
102	Encephalomalacia	14.9%
103	Epilepsy	14.9%
104	Hydrocephalus	14.9%
105	Congenital Hydrocephalus	14.9%
106	Hypothalamic Diseases	14.9%
107	Thalamic Diseases	14.9%
108	Intracranial Hypertension	14.9%
109	Aura	14.9%
110	Neuroaxonal Dystrophies	14.9%
111	Headache Disorders	14.9%
112	Intracranial Hypotension	14.9%
113	Brain Edema	14.9%
114	Brain Hypoxia	14.9%
115	Aqueductal Stenosis	14.9%
116	Restless Legs Syndrome	14.8%
117	Lupus Vasculitis, Central Nervous System	14.6%
118	Smith-Magenis syndrome	14.6%
119	Myasthenic Syndromes, Congenital	14.5%
120	Myelitis	14.5%
121	Cytochrome-c Oxidase Deficiency	14.5%
122	Opsoclonus-Myoclonus Syndrome	14.1%
123	Meningitis	13.9%
124	Movement Disorders	13.9%
125	Pachymeningitis	13.9%
126	Spinal Cord Diseases	13.9%
127	Brain Death	13.8%
128	Hyperhomocysteinemia	13.7%
129	Neuroleptic Malignant Syndrome	13.7%
130	Presenile dementia	13.6%
131	Senile dementia	13.6%
132	Amblyopia	13.6%
133	Cranial nerve diseases	13.5%
134	Neuromuscular Diseases	13.5%
135	Chronobiology Disorders	13.5%
136	Cerebrovascular Disorders	13.5%
137	Cerebrovascular Insufficiency	13.5%
138	Dementia	13.5%
139	Rett Syndrome	13.4%
140	Poliomyelitis	13.4%
141	Lactose Intolerance	13.4%
142	Neuromyelitis Optica	13.3%
143	Guillain-Barre Syndrome	13.2%
144	Cerebellar Neoplasms	13.2%
145	Spinal Cord Injuries	13%
146	Familial Periodic Paralysis	12.8%
147	Asterixis	12.8%
148	Ballismus	12.8%
149	Hypolipoproteinemias	12.8%
150	Central Nervous System Infection	12.8%
151	Brain Diseases, Metabolic	12.8%
152	Meige Syndrome	12.8%
153	Cerebral Ventriculitis	12.8%
154	Lambert-Eaton Myasthenic Syndrome	12.7%
155	Vascular Headaches	12.5%
156	Hypoxia-Ischemia, Brain	12.5%
157	Paraneoplastic Cerebellar Degeneration	12.4%
158	Trauma, Nervous System	12.4%
159	Muscular Dystrophy, Duchenne	12.4%
160	Nervous System Neoplasms	12.3%
161	Neurologic Manifestations	12.3%
162	Neurotoxicity Syndromes	12.3%
163	Sjogren-Larsson Syndrome	12.2%
164	Mucopolysaccharidosis III	12.1%
165	Chronic Fatigue Syndrome	12%
166	Brain Hemorrhage, Traumatic	12%
167	MPTP Poisoning	12%
168	Muscular Dystrophy	12%
169	Amnesia, Transient Global	11.9%
170	Tauopathies	11.9%
171	Hyperlipidemia, Familial Combined	11.9%
172	Wasting Syndrome	11.9%
173	Familial Hypophosphatemic Rickets	11.8%
174	Alexander Disease	11.8%
175	Holoprosencephaly	11.8%
176	Brain Diseases, Metabolic, Inborn	11.8%
177	Cystic Fibrosis	11.7%
178	Hyperlipoproteinemia Type IV	11.7%
179	Hyperlipoproteinemia Type V	11.7%
180	Creutzfeldt-Jakob disease	11.6%
181	Vasculitis, Central Nervous System	11.6%
182	Hyperlipoproteinemia Type III	11.4%
183	CHARGE Syndrome	11.3%
184	Sleep Wake Disorders	11.3%
185	Dyskinesia, Drug-Induced	11.2%
186	Cri-du-Chat Syndrome	11.2%
187	Down Syndrome	11.2%
188	Trisomy 21	11.2%
189	Alkaptonuria	11.1%
190	Glycogen Storage Disease	11.1%
191	Hypophosphatasia	11.1%
192	Propionic acidemia	11.1%
193	Dihydropyrimidine Dehydrogenase Deficiency	11.1%
194	Cystinosis	11.1%
195	Myoclonic Epilepsy	11.1%
196	Epilepsy, Temporal Lobe	11.1%
197	Epilepsy, Rolandic	11.1%
198	Benign Rolandic Epilepsy	11.1%
199	Prader-Willi Syndrome	11.1%
200	Autonomic Dysreflexia	11%
201	Complex Regional Pain Syndromes	11%
202	Basal Ganglia Hemorrhage	10.9%
203	Carotid Artery Injuries	10.9%
204	Central Nervous System Cysts	10.9%
205	Progressive bulbar palsy	10.9%
206	Bulbar palsy	10.9%
207	Akathisia, Drug-Induced	10.9%
208	Pituitary Adenoma	10.9%
209	Pituitary Neoplasms	10.9%
210	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	10.9%
211	Renal tubular acidosis	10.8%
212	Meningitis, Bacterial	10.8%
213	Meningitis, Fungal	10.8%
214	Toxoplasmosis, Cerebral	10.7%
215	Anemia, Sickle Cell	10.6%
216	Thalassemia	10.6%
217	Neoplastic Syndromes, Hereditary	10.5%
218	Nail-Patella Syndrome	10.4%
219	Scrapie	10.4%
220	Kartagener Syndrome	10.4%
221	Spinal Cord Neoplasms	10.3%
222	Multiple Epiphyseal Dysplasia	10.3%
223	Osteochondrodysplasias	10.3%
224	Pelger-Huet Anomaly	10.3%
225	Frontotemporal dementia	10.2%
226	Peripheral Nerve Injuries	10%
227	Brain Injuries, Diffuse	10%
228	Traumatic Brain Injury	10%
229	Myasthenia Gravis	10%
230	Cerebellar Ataxia	10%
231	Supratentorial Neoplasms	10%
232	Rubinstein-Taybi Syndrome	9.9%
233	Multiple Sclerosis	9.9%
234	Demyelinating Diseases	9.8%
235	Demyelination	9.8%
236	Paraneoplastic Encephalomyelitis	9.8%
237	Acid-Base Imbalance	9.8%
238	Calcium Metabolism Disorders	9.8%
239	Iron Metabolism Disorders	9.8%
240	Phosphorus Metabolism Disorders	9.8%
241	Water-Electrolyte Imbalance	9.8%
242	Lipid Metabolism Disorders	9.8%
243	Mitochondrial Diseases	9.8%
244	Glucose Metabolism Disorders	9.8%
245	Hypercalcemia	9.7%
246	Hypocalcemia	9.7%
247	Milk-Alkali Syndrome	9.7%
248	Antley-Bixler Syndrome Phenotype	9.7%
249	Beckwith-Wiedemann Syndrome	9.6%
250	Wolf-Hirschhorn Syndrome	9.6%
251	Dwarfism	9.6%
252	Porphyrias, Hepatic	9.4%
253	Williams Syndrome	9.4%
254	Persistent Vegetative State	9.4%
255	Osteogenesis Imperfecta	9.4%
256	Marfan Syndrome	9.3%
257	Glycosuria, Renal	9.3%
258	Pituitary Apoplexy	9.3%
259	Sleep Disorders, Circadian Rhythm	9.3%
260	Fanconi Anemia	9.3%
261	Renal Aminoacidurias	9.3%
262	Fanconi Syndrome	9.3%
263	Pseudohypoaldosteronism	9.3%
264	Liddle Syndrome	9.3%
265	Olfactory Nerve Injuries	9.3%
266	Brain Infarction	9.3%
267	Botulism	9.1%
268	Wiskott-Aldrich Syndrome	9.1%
269	Cerebral Palsy	9.1%
270	Epilepsies, Partial	9.1%
271	Epilepsy, Generalized	9.1%
272	Pseudotumor Cerebri	9.1%
273	Hypertensive Encephalopathy	9.1%
274	Simple Partial Seizures	9.1%
275	Epilepsy, Reflex	9.1%
276	Headache Disorders, Primary	9.1%
277	Headache Disorders, Secondary	9.1%
278	Medication overuse headache	9.1%
279	Hypokalemic periodic paralysis	8.9%
280	Hydranencephaly	8.9%
281	Neural Tube Defects	8.9%
282	Tethered Cord Syndrome	8.9%
283	Iniencephaly	8.9%
284	Craniorachischisis	8.9%
285	Exencephaly	8.9%
286	Septo-Optic Dysplasia	8.9%
287	Cortical Dysplasia	8.9%
288	Malformations of Cortical Development	8.9%
289	Hypoalphalipoproteinemias	8.9%
290	Causalgia	8.9%
291	Osteopenia	8.9%
292	Lipodystrophy	8.9%
293	Duane Retraction Syndrome	8.9%
294	Classical Lissencephalies and Subcortical Band Heterotopias	8.8%
295	Gout	8.7%
296	Autoimmune Lymphoproliferative Syndrome	8.7%
297	Dural Arteriovenous Fistula	8.7%
298	Putaminal Hemorrhage	8.6%
299	Tuberculosis, Meningeal	8.6%
300	Facial Nerve Injuries	8.6%
301	Leukoencephalopathy	8.6%
302	Angioedemas, Hereditary	8.5%
303	Rickets	8.5%
304	Juvenile Myoclonic Epilepsy	8.5%
305	Myoclonic Epilepsies, Progressive	8.5%
306	Xeroderma Pigmentosum	8.4%
307	Pituitary Diseases	8.3%
308	Mitochondrial Myopathies	8.3%
309	Carotid Artery Diseases	8.2%
310	Brain Ischemia	8.2%
311	Cerebrovascular accident	8.2%
312	Kluver-Bucy Syndrome	8.2%
313	Vasospasm, Intracranial	8.2%
314	Intracranial Arterial Diseases	8.2%
315	Ectodermal Dysplasia	8.2%
316	Aplasia Cutis Congenita	8.2%
317	Infarction, Middle Cerebral Artery	8.2%
318	Infarction, Anterior Cerebral Artery	8.2%
319	Infarction, Posterior Cerebral Artery	8.2%
320	Mobius Syndrome	8.1%
321	Kallmann Syndrome	8.1%
322	Central Cord Syndrome	8%
323	Horner Syndrome	8%
324	Arachnoiditis	8%
325	Aseptic Meningitis	8%
326	Syringomyelia	8%
327	Essential Tremor	8%
328	Familial Tremor	8%
329	Pneumorrhachis	8%
330	Writer's Cramp	8%
331	Chorea	7.9%
332	Myasthenia Gravis, Autoimmune, Experimental	7.9%
333	Glycogen Storage Disease Type I	7.9%
334	Glycogen Storage Disease Type V	7.9%
335	Auditory Perceptual Disorders	7.9%
336	Congenital Hyperinsulinism	7.8%
337	Welander Distal Myopathy	7.7%
338	Moyamoya Disease	7.6%
339	Subarachnoid Hemorrhage, Traumatic	7.5%
340	Carotid Artery, Internal, Dissection	7.5%
341	Brain Concussion	7.5%
342	Dysautonomia	7.5%
343	Vagus Nerve Disorder	7.5%
344	Glossopharyngeal Neuralgia	7.5%
345	Abducens Nerve Diseases	7.5%
346	Heavy Metal Poisoning, Nervous System	7.5%
347	Neuromuscular Junction Diseases	7.5%
348	Trochlear Nerve Diseases	7.5%
349	Peripheral Nervous System Diseases	7.5%
350	Vertebral Artery Dissection	7.5%
351	Intracranial Embolism and Thrombosis	7.4%
352	Jet Lag Syndrome	7.4%
353	Kearns-Sayre syndrome	7.4%
354	Subacute Sclerosing Panencephalitis	7.3%
355	Central Nervous System Fungal Infections	7.3%
356	Conus Medullaris Syndrome	7.3%
357	Spinal Cord Vascular Diseases	7.3%
358	Sickle Cell Trait	7.2%
359	Cerebral Infarction	7.1%
360	Brain Stem Infarctions	7.1%
361	Alice in Wonderland Syndrome	7.1%
362	Polycystic Kidney Diseases	7%
363	Familial Mediterranean Fever	7%
364	Diffuse Axonal Injury	7%
365	Anencephaly	7%
366	Brain Stem Neoplasms	7%
367	Bloom Syndrome	7%
368	Reflex Sympathetic Dystrophy	7%
369	Nocturnal Myoclonus Syndrome	7%
370	Ophthalmoplegia	7%
371	External Ophthalmoplegia	7%
372	Myopathy	6.9%
373	Optic Neuropathy	6.9%
374	Multiple Sclerosis, Chronic Progressive	6.9%
375	Multiple Sclerosis, Relapsing-Remitting	6.9%
376	Facial Nerve Diseases	6.8%
377	Craniocerebral Trauma	6.8%
378	Parasomnia	6.8%
379	Dyssomnias	6.8%
380	Deformity	6.8%
381	Vestibulocochlear Nerve Diseases	6.8%
382	Decerebrate State	6.8%
383	Hemiparesis	6.8%
384	Meningism	6.8%
385	Paresis	6.8%
386	Seizures	6.8%
387	Sensation Disorders	6.8%
388	Central Nervous System Neoplasms	6.8%
389	Complex partial seizures	6.8%
390	Monoparesis	6.8%
391	Neurogenic Inflammation	6.8%
392	Gait Disorders, Neurologic	6.8%
393	Neuromuscular Manifestations	6.8%
394	Sweating, Gustatory	6.8%
395	Auriculotemporal Syndrome	6.8%
396	Torticollis	6.7%
397	Primary Ciliary Dyskinesia	6.7%
398	Central Nervous System Bacterial Infections	6.7%
399	Retinal Dysplasia	6.6%
400	Aniridia	6.6%
401	Meningitis, Cryptococcal	6.6%
402	Meningitis, Listeria	6.6%
403	Meningitis, Haemophilus	6.6%
404	Meningitis, Pneumococcal	6.6%
405	Cystinuria	6.6%
406	Epidermolysis Bullosa	6.5%
407	Cerebral Amyloid Angiopathy	6.5%
408	Giant Cell Arteritis	6.5%
409	Temporal Arteritis	6.5%
410	Vocal Cord Paralysis	6.5%
411	Brain Contusion	6.4%
412	Tetany	6.4%
413	Acrodynia	6.3%
414	Acute Chest Syndrome	6.3%
415	AIDS Dementia Complex	6.3%
416	Pupil Disorders	6.3%
417	Neurobehavioral Manifestations	6.3%
418	Nutrition Disorders	6.3%
419	Uveomeningoencephalitic Syndrome	6.2%
420	Post-Traumatic Headache	6.2%
421	Tension Headache	6.2%
422	Epilepsy, Complex Partial	6.2%
423	Migraine Disorders	6.2%
424	Abdominal Migraine	6.2%
425	Status Migrainosus	6.2%
426	Cervicogenic Headache	6.2%
427	Fetal Diseases	6.2%
428	Sturge-Weber Syndrome	6.2%
429	Vertigo	6.2%
430	Alcohol-Induced Disorders, Nervous System	6.2%
431	Toxoplasmosis, Congenital	6.1%
432	Arthritis, Gouty	6.1%
433	Variegate Porphyria	6.1%
434	Acute intermittent porphyria	6.1%
435	Porphyria Cutanea Tarda	6.1%
436	Lateral Medullary Syndrome	6%
437	Alcohol Withdrawal Seizures	5.9%
438	Optic Nerve Glioma	5.9%
439	Cutis Laxa	5.8%
440	Cerebrospinal Fluid Otorrhea	5.8%
441	Cerebrospinal Fluid Rhinorrhea	5.8%
442	Neuritis, Autoimmune, Experimental	5.8%
443	Gait Ataxia	5.8%
444	Retinitis Pigmentosa	5.8%
445	Pigmentary retinopathy	5.8%
446	Porokeratosis	5.8%
447	Keratoderma, Palmoplantar	5.8%
448	Chronic granulomatous disease	5.8%
449	Voice Disorders	5.7%
450	Voice Disturbance	5.7%
451	Congenital nystagmus	5.7%
452	Pseudoxanthoma Elasticum	5.7%
453	Brachial Plexus Neuritis	5.6%
454	Neuralgic Amyotrophy	5.6%
455	Empty Sella Syndrome	5.6%
456	Hyperpituitarism	5.6%
457	Hypopituitarism	5.6%
458	Hypophysitis	5.6%
459	West Nile Fever	5.6%
460	Meningomyelocele	5.6%
461	Spina Bifida	5.6%
462	Cerebral Arterial Diseases	5.6%
463	Vertebrobasilar Insufficiency	5.6%
464	Basilar Artery Stenosis	5.6%
465	Vertebral Artery Stenosis	5.6%
466	Intracranial Hemorrhage, Hypertensive	5.6%
467	Transient Cerebral Ischemia	5.6%
468	Tardive Dyskinesia	5.6%
469	Choroid Plexus Papilloma	5.5%
470	Coma, Post-Head Injury	5.4%
471	Acidosis	5.4%
472	Alkalosis	5.4%
473	Amyloidosis	5.4%
474	Calcinosis	5.4%
475	Hyperglycemia	5.4%
476	Hyperinsulinism	5.4%
477	Hyperkalemia	5.4%
478	Hypernatremia	5.4%
479	Hypoglycemia	5.4%
480	Hypokalemia	5.4%
481	Hyponatremia	5.4%
482	Xanthomatosis	5.4%
483	Hypophosphatemia	5.4%
484	Metabolic acidosis	5.4%
485	Dyslipidemias	5.4%
486	Iron Overload	5.4%
487	Xanthoma	5.4%
488	Meconium Aspiration Syndrome	5.4%
489	Akathisia	5.4%
490	Restlessness	5.4%
491	Psychomotor Agitation	5.4%
492	Peutz-Jeghers Syndrome	5.3%
493	Thrombasthenia	5.3%
494	Antithrombin III Deficiency	5.3%
495	Protein C Deficiency	5.3%
496	Afibrinogenemia	5.3%
497	Factor VII Deficiency	5.3%
498	Factor X Deficiency	5.3%
499	Factor XII Deficiency	5.3%
500	Hemophilia A	5.3%
501	Activated Protein C Resistance	5.3%
502	Factor II deficiency	5.3%
503	Factor VIII Deficiency	5.3%
504	Factor V deficiency	5.3%
505	Factor XI Deficiency	5.3%
506	Hypoprothrombinemias	5.3%
507	Anemia, Diamond-Blackfan	5.2%
508	Reflex, Abnormal	5.2%
509	Hyporeflexia	5.2%
510	Hyperreflexia	5.2%
511	Osteomalacia	5.2%
512	Meningocele	5.1%
513	Encephalocele	5.1%
514	Carotid Stenosis	5.1%
515	Intracranial Aneurysm	5.1%
516	Hematoma, Subdural	5.1%
517	Hematoma, Epidural, Cranial	5.1%
518	Intracranial Arteriosclerosis	5.1%
519	Cerebral Atherosclerosis	5.1%
520	Subarachnoid Hemorrhage	5.1%
521	Cerebral Arteriosclerosis	5.1%
522	Cerebral Hemorrhage	5.1%
523	Cerebral Thrombosis	5%
524	Intracranial Embolism	5%
525	Intracranial Thrombosis	5%
526	HIV Wasting Syndrome	5%
527	Tarsal Tunnel Syndrome	5%
528	Cauda Equina Syndrome	5%
529	Nesidioblastosis	5%
530	Basal Cell Nevus Syndrome	5%
531	Multiple Endocrine Neoplasia	5%
532	Diabetes Mellitus	5%
533	Hyperkeratosis, Epidermolytic	4.9%
534	Congenital Hypothyroidism	4.9%
535	Dehydration	4.9%
536	Lipomatosis	4.9%
537	Water Intoxication	4.9%
538	Dermatitis, Atopic	4.9%
539	Achlorhydria	4.9%
540	Osteoporosis	4.9%
541	Bone Demineralization, Pathologic	4.9%
542	Post-Traumatic Osteoporosis	4.9%
543	Acoustic Neuroma	4.9%
544	Celiac Disease	4.9%
545	Sprue, Tropical	4.9%
546	Steatorrhea	4.9%
547	Sprue	4.9%
548	Gait Apraxia	4.8%
549	Polycystic Kidney, Autosomal Dominant	4.8%
550	Cluster Headache	4.7%
551	Migraine with Aura	4.7%
552	Familial Hemiplegic Migraine	4.7%
553	Chronic Paroxysmal Hemicrania	4.7%
554	SUNCT Syndrome	4.7%
555	Paroxysmal Hemicrania	4.7%
556	Xeroderma	4.6%
557	Carotid Artery Thrombosis	4.6%
558	Spinal Cord Ischemia	4.6%
559	Neuritis	4.6%
560	Polyneuritis	4.6%
561	Radiculitis	4.6%
562	Polyneuropathy	4.6%
563	Mononeuritis	4.6%
564	Mononeuropathies	4.6%
565	Brachial Plexus Neuropathies	4.6%
566	Radiculopathy	4.6%
567	Mononeuropathy Multiplex	4.6%
568	Nerve Root Compression	4.6%
569	Tuberculosis, Central Nervous System	4.6%
570	Carpal Tunnel Syndrome	4.6%
571	Behcet Syndrome	4.6%
572	neurofibroma	4.5%
573	Sciatica	4.5%
574	Microcephaly	4.5%
575	Macrocephaly	4.5%
576	Glycosuria	4.4%
577	Diabetic Ketoacidosis	4.4%
578	Brain Diseases	4.4%
579	Hyperprolactinemia	4.3%
580	Subclavian Steal Syndrome	4.3%
581	Pick Disease of the Brain	4.3%
582	Porencephaly	4.2%
583	Neuroaspergillosis	4.2%
584	Myositis	4.2%
585	Optic Atrophy	4.2%
586	Optic Neuritis	4.2%
587	Papilledema	4.2%
588	Strabismus	4.2%
589	Tolosa-Hunt Syndrome	4.2%
590	Isaacs syndrome	4.2%
591	Arsenic Poisoning	4.2%
592	Myotonic Disorders	4.2%
593	HIV-Associated Lipodystrophy Syndrome	4.2%
594	Renal Osteodystrophy	4.1%
595	Renal rickets	4.1%
596	Diabetic Neuropathies	4.1%
597	Facial Injuries	4.1%
598	Facial Neuralgia	4.1%
599	Diabetic Amyotrophy	4.1%
600	Diabetic Autonomic Neuropathy	4.1%
601	Sleep Talking	4.1%
602	Manganese Poisoning	4.1%
603	Sleep Disorders, Intrinsic	4.1%
604	Orthostatic intolerance	4.1%
605	Anosmia	4.1%
606	Ataxia	4.1%
607	Athetosis	4.1%
608	Catalepsy	4.1%
609	Dystonia	4.1%
610	Hemiplegia	4.1%
611	Locked-In Syndrome	4.1%
612	Meningeal Neoplasms	4.1%
613	Muscle Hypertonia	4.1%
614	Muscle hypotonia	4.1%
615	Myoclonus	4.1%
616	Myotonia	4.1%
617	Neuralgia	4.1%
618	Paraplegia	4.1%
619	Pseudobulbar Palsy	4.1%
620	Quadriplegia	4.1%
621	Spasm	4.1%
622	Spastic Paraplegia	4.1%
623	Status Epilepticus	4.1%
624	Taste Disorders	4.1%
625	Tremor	4.1%
626	Monoplegia	4.1%
627	Hypokinesia	4.1%
628	Paraparesis	4.1%
629	Bradykinesia	4.1%
630	Waxy flexibility	4.1%
631	Action Tremor	4.1%
632	Resting Tremor	4.1%
633	Dysosmia	4.1%
634	Quadriparesis	4.1%
635	Mercury Poisoning, Nervous System	4.1%
636	Olfaction Disorders	4.1%
637	Myokymia	4.1%
638	Lead Poisoning, Nervous System	4.1%
639	Vestibular Neuronitis	4.1%
640	Somatosensory Disorders	4.1%
641	Neuropathic pain	4.1%
642	Hyperkinesia	4.1%
643	Intention tremor	4.1%
644	POEMS Syndrome	4.1%
645	Hematoma, Subdural, Intracranial	4.1%
646	Hematoma, Subdural, Chronic	4.1%
647	Hematoma, Subdural, Acute	4.1%
648	Necrobiosis Lipoidica Diabeticorum	4.1%
649	Papillon-Lefevre Disease	4%
650	Nephroblastoma	4%
651	Cubital Tunnel Syndrome	4%
652	Pseudorabies	4%
653	Dermal Sinus	3.9%
654	Spina Bifida Cystica	3.9%
655	Spina Bifida Occulta	3.9%
656	Lissencephaly	3.9%
657	Polymicrogyria	3.9%
658	Pachygyria	3.9%
659	Schizencephaly	3.9%
660	Periventricular Nodular Heterotopia	3.9%
661	Turner Syndrome	3.9%
662	Acromegaly	3.9%
663	Hand-Arm Vibration Syndrome	3.9%
664	Sinus Thrombosis, Intracranial	3.9%
665	Neurosyphilis	3.8%
666	Vision Disorders	3.8%
667	Metamorphopsia	3.8%
668	Visual Impairment	3.8%
669	Fibromyalgia	3.8%
670	Optic Neuropathy, Ischemic	3.8%
671	Anterior Ischemic Optic Neuropathy	3.8%
672	Medial Tibial Stress Syndrome	3.8%
673	Abdominal Cramps	3.8%
674	Abnormalities, Drug-Induced	3.8%
675	Amniotic Band Syndrome	3.8%
676	Asphyxia Neonatorum	3.8%
677	Infant, Premature, Diseases	3.8%
678	Situs Inversus	3.8%
679	Infantile Colic	3.8%
680	Facial Hemiatrophy	3.8%
681	Melkersson-Rosenthal Syndrome	3.8%
682	Anisocoria	3.8%
683	Confusion	3.8%
684	Facial paralysis	3.8%
685	Lethargy	3.8%
686	Memory Disorders	3.8%
687	Muscle Cramp	3.8%
688	Perceptual Disorders	3.8%
689	Psychomotor Disorders	3.8%
690	Tonic Pupil	3.8%
691	Eosinophilia-Myalgia Syndrome	3.8%
692	Anhedonia	3.8%
693	Disorientation	3.8%
694	Facial Paresis	3.8%
695	Memory Loss	3.8%
696	Hemisensory Neglect	3.8%
697	Dysacusis	3.8%
698	Sleep Bruxism	3.8%
699	Muscular Atrophy	3.8%
700	Respiratory Paralysis	3.8%
701	Klinefelter Syndrome	3.8%
702	Adenomatous Polyposis Coli	3.7%
703	Hydrops Fetalis	3.7%
704	Lyme Neuroborreliosis	3.5%
705	Waterhouse-Friderichsen Syndrome	3.5%
706	Eye Abnormalities	3.5%
707	Cardiovascular Abnormalities	3.5%
708	Consciousness Disorders	3.5%
709	Mental Retardation	3.5%
710	Muscle Weakness	3.5%
711	Depressed Level of Consciousness	3.5%
712	Mental deficiency	3.5%
713	Intellectual Disability	3.5%
714	Bell Palsy	3.5%
715	Catatonia	3.5%
716	Herpes Zoster Oticus	3.5%
717	Aphonia	3.5%
718	Sleep Deprivation	3.5%
719	Dysphonia	3.5%
720	Skin Abnormalities	3.5%
721	Lymphatic Abnormalities	3.5%
722	Congenital Microtia	3.5%
723	Anemia, Neonatal	3.4%
724	Persistent Fetal Circulation Syndrome	3.4%
725	Congenital diaphragmatic hernia	3.4%
726	Umbilical hernia	3.4%
727	Multiple Endocrine Neoplasia Type 1	3.4%
728	Alexia	3.3%
729	Dyslexia	3.3%
730	Anterior Spinal Artery Syndrome	3.3%
731	Prolactinoma	3.3%
732	Growth Hormone-Secreting Pituitary Adenoma	3.3%
733	Cavernous Sinus Thrombosis	3.3%
734	Sagittal Sinus Thrombosis	3.3%
735	Child Nutrition Disorders	3.3%
736	Hypervitaminosis A	3.3%
737	Infant Nutrition Disorders	3.3%
738	Malnutrition	3.3%
739	Acidosis, Lactic	3.2%
740	Calciphylaxis	3.2%
741	Hemosiderosis	3.2%
742	Ketosis	3.2%
743	Ketonuria	3.2%
744	Ketoacidosis	3.2%
745	Ketonemia	3.2%
746	Vascular calcification	3.2%
747	Urogenital Abnormalities	3.2%
748	Myalgia	3.2%
749	Neonatal Abstinence Syndrome	3.2%
750	Sciatic Neuropathy	3.1%
751	Ulnar Neuropathies	3.1%
752	Lesion of Sciatic Nerve	3.1%
753	Ulnar Neuritis	3.1%
754	Radial nerve compression	3.1%
755	Radial Tunnel Syndrome	3.1%
756	Peroneal Neuropathies	3.1%
757	Radial Neuropathy	3.1%
758	Median Neuropathy	3.1%
759	Sciatic Nerve Palsy	3.1%
760	Femoral Neuropathy	3.1%
761	Tibial Neuropathy	3.1%
762	Ulnar Nerve Palsy	3.1%
763	Postural Orthostatic Tachycardia Syndrome	3.1%
764	Radial nerve palsy	3.1%
765	Fetal Growth Retardation	3.1%
766	Fetal Hypoxia	3.1%
767	Fetal Alcohol Spectrum Disorders	3.1%
768	Syphilis, Congenital	3.1%
769	Neurofibrosarcoma	3.1%
770	Malaria, Cerebral	3%
771	Nelson Syndrome	3%
772	Neurocysticercosis	3%
773	Maxillofacial Abnormalities	3%
774	Hoarseness	3%
775	Dextrocardia	3%
776	Alcohol Withdrawal Delirium	3%
777	Acidosis, Respiratory	2.9%
778	Adiposis Dolorosa	2.9%
779	Alkalosis, Respiratory	2.9%
780	Insulin Resistance	2.9%
781	Osteoporosis, Postmenopausal	2.9%
782	Chorioamnionitis	2.9%
783	Thoracic Outlet Syndrome	2.9%
784	Esotropia	2.8%
785	Exotropia	2.8%
786	Hypotension, Orthostatic	2.8%
787	Sleep Apnea Syndromes	2.8%
788	Polymyositis	2.8%
789	Post-Exercise Hypotension	2.8%
790	Disorders of Excessive Somnolence	2.8%
791	Sleep Initiation and Maintenance Disorders	2.8%
792	Night Terrors	2.8%
793	Somnambulism	2.8%
794	Trigeminal Nerve Disorder	2.8%
795	Transient Insomnia	2.8%
796	Sleep Paralysis	2.8%
797	Chronic Insomnia	2.8%
798	REM Sleep Behavior Disorder	2.8%
799	Hypersomnia	2.8%
800	Dysgeusia	2.8%
801	Formication	2.8%
802	Hyperalgesia	2.8%
803	Hyperesthesia	2.8%
804	Hypesthesia	2.8%
805	Language Disorders	2.8%
806	Numbness	2.8%
807	Paresthesia	2.8%
808	Paraparesis, Spastic	2.8%
809	Trismus	2.8%
810	Epilepsia Partialis Continua	2.8%
811	Hypogeusia	2.8%
812	Meningeal Carcinomatosis	2.8%
813	Brown-Sequard Syndrome	2.8%
814	Lockjaw	2.8%
815	Allodynia	2.8%
816	Lead Poisoning, Nervous System, Childhood	2.8%
817	Lead Poisoning, Nervous System, Adult	2.8%
818	Ageusia	2.8%
819	Denys-Drash Syndrome	2.7%
820	Gestational Diabetes	2.7%
821	Latent Autoimmune Diabetes in Adults	2.7%
822	Diabetes Mellitus, Experimental	2.7%
823	Nephrocalcinosis	2.6%
824	Abnormalities, Radiation-Induced	2.6%
825	Eye Injuries	2.6%
826	Scimitar Syndrome	2.6%
827	Orbital Myositis	2.6%
828	Diplopia	2.6%
829	Muscle Rigidity	2.6%
830	Muscle Spasticity	2.6%
831	Scotoma	2.6%
832	Photophobia	2.6%
833	Cogwheel Rigidity	2.6%
834	Hemifacial Spasm	2.6%
835	Amaurosis	2.6%
836	Blindness	2.6%
837	Nuchal Rigidity	2.6%
838	Pyomyositis	2.6%
839	Agnosia	2.6%
840	Apraxias	2.6%
841	Hallucinations	2.6%
842	Hemianopsia	2.6%
843	Hyperacusis	2.6%
844	Tinnitus	2.6%
845	Visual Agnosia	2.6%
846	Anosognosia	2.6%
847	Wernicke-Korsakoff Syndrome	2.6%
848	Phonophobia	2.6%
849	Hearing Loss	2.6%
850	Sarcopenia	2.6%
851	Acrocephalosyndactylia	2.5%
852	Primary amyloidosis	2.4%
853	Ophthalmia Neonatorum	2.4%
854	Polyradiculopathy	2.4%
855	Amnesia	2.4%
856	Delirium	2.4%
857	Dissociative Amnesia	2.4%
858	Color blindness	2.4%
859	Global Amnesia	2.4%
860	Meningioma	2.4%
861	Prune Belly Syndrome	2.3%
862	Twins, Conjoined	2.3%
863	Waardenburg Syndrome	2.3%
864	Craniosynostosis	2.2%
865	Syndactyly	2.2%
866	Brachycephaly	2.2%
867	Sleep Apnea, Obstructive	2.2%
868	Sleep Apnea, Central	2.2%
869	Phantom pain	2.2%
870	Phantom Limb Pain	2.2%
871	Narcolepsy	2.2%
872	Trigeminal Neuralgia	2.2%
873	Kleine-Levin Syndrome	2.2%
874	Agraphia	2.2%
875	Anomia	2.2%
876	Cluttering	2.2%
877	Language Development Disorders	2.2%
878	Speech Disorders	2.2%
879	Syncope	2.2%
880	Stupor	2.2%
881	Dysgraphia	2.2%
882	Presyncope	2.2%
883	Dyslalia	2.2%
884	Hypercholesterolemia	2.1%
885	Hyperlipoproteinemias	2.1%
886	Hypertriglyceridemia	2.1%
887	Anophthalmos	2.1%
888	Anus, Imperforate	2.1%
889	Microphthalmos	2.1%
890	Paralysis, Obstetric	2.1%
891	Retinopathy of Prematurity	2.1%
892	Limb Deformities, Congenital	2.1%
893	Craniofacial Abnormalities	2.1%
894	Anorectal Malformations	2.1%
895	Bronchopulmonary Dysplasia	2.1%
896	Noonan Syndrome	2.1%
897	Cleft Palate	2.1%
898	CREST Syndrome	2.1%
899	Eye Burns	2%
900	Amaurosis Fugax	2%
901	Blindness, Cortical	2%
902	Dyscalculia	2%
903	Deafness	2%
904	Hearing Loss, Sudden	2%
905	Gerstmann Syndrome	2%
906	Hearing Loss, Bilateral	2%
907	Hearing Loss, High-Frequency	2%
908	Hearing Loss, Mixed Conductive-Sensorineural	2%
909	Prosopagnosia	2%
910	Apraxia, Ideomotor	2%
911	Charles Bonnet Syndrome	2%
912	Hearing Loss, Unilateral	2%
913	Complete Hearing Loss	2%
914	Alien Hand Syndrome	2%
915	Deaf Mutism	2%
916	Blepharophimosis	1.9%
917	Laryngostenosis	1.9%
918	Mouth Abnormalities	1.9%
919	Respiratory Distress Syndrome, Newborn	1.9%
920	Esophageal Atresia	1.9%
921	Intestinal Atresia	1.9%
922	Horseshoe Kidney	1.9%
923	Pectus excavatum	1.9%
924	Klippel-Feil Syndrome	1.9%
925	Gastroschisis	1.9%
926	Synostosis	1.9%
927	Acrodermatitis	1.9%
928	Lymphangiectasis, Intestinal	1.9%
929	Gianotti-Crosti Syndrome	1.9%
930	Jaw Abnormalities	1.9%
931	Cataplexy	1.8%
932	Aphasia	1.8%
933	Articulation Disorders	1.8%
934	Echolalia	1.8%
935	Stuttering	1.8%
936	Dysphasia	1.8%
937	Dermatomyositis	1.8%
938	Corneal Scar	1.8%
939	Retrograde amnesia	1.8%
940	Amnesia, Anterograde	1.8%
941	Deficiency Diseases	1.8%
942	Starvation	1.8%
943	Refeeding Syndrome	1.8%
944	Arthrogryposis	1.8%
945	Choanal Atresia	1.8%
946	Tracheobronchomegaly	1.8%
947	Laryngocele	1.8%
948	Choledochal Cyst	1.8%
949	Hermaphroditism	1.8%
950	Disorders of Sex Development	1.8%
951	Cryptorchidism	1.8%
952	Hypospadias	1.8%
953	Poland Syndrome	1.7%
954	Mutism	1.7%
955	Selective Mutism	1.7%
956	Dysarthria	1.7%
957	Laryngomalacia	1.7%
958	Pectus carinatum	1.7%
959	Bladder Exstrophy	1.6%
960	Epispadias	1.6%
961	Multicystic Dysplastic Kidney	1.6%
962	Corneal Perforation	1.5%
963	Alexia, Pure	1.5%
964	Micrognathism	1.5%
965	Pierre Robin Syndrome	1.5%
966	Amelia	1.5%
967	Arachnodactyly	1.5%
968	Ectopia Cordis	1.5%
969	Ectromelia	1.5%
970	Hemimelia	1.5%
971	Phocomelia	1.5%
972	Sirenomelia	1.5%
973	Polydactyly	1.5%
974	Brachydactyly	1.5%
975	Plagiocephaly	1.5%
976	Lower Extremity Deformities, Congenital	1.5%
977	Upper Extremity Deformities, Congenital	1.5%
978	Single umbilical artery	1.5%
979	Hyperandrogenism	1.4%
980	Retrognathia	1.4%
981	Obesity	1.3%
982	Aortic coarctation	1.3%
983	Cor Triatriatum	1.3%
984	Coronary Vessel Anomalies	1.3%
985	Dental Enamel Hypoplasia	1.3%
986	Patent ductus arteriosus	1.3%
987	Ebstein Anomaly	1.3%
988	Heart Septal Defects	1.3%
989	Hyaline Membrane Disease	1.3%
990	Hypodontia	1.3%
991	Macrostomia	1.3%
992	Microstomia	1.3%
993	Tetralogy of Fallot	1.3%
994	Transposition of Great Vessels	1.3%
995	Hypoplastic Left Heart Syndrome	1.3%
996	May-Thurner Syndrome	1.3%
997	Craniofacial Dysostosis	1.3%
998	Wolff-Parkinson-White Syndrome	1.3%
999	Prognathism	1.3%
1000	Long QT Syndrome	1.2%
1001	Platybasia	1.2%
1002	Tricuspid Atresia	1.2%
1003	Arrhythmogenic Right Ventricular Dysplasia	1.2%
1004	Gonadal Dysgenesis	1.2%
1005	Bronchomalacia	1.2%
1006	Adrenogenital Syndrome	1.2%
1007	Tracheomalacia	1.2%
1008	Ovotesticular Disorders of Sex Development	1.2%
1009	Kwashiorkor	1.1%
1010	Magnesium Deficiency	1.1%
1011	Potassium Deficiency	1.1%
1012	Protein Deficiency	1.1%
1013	Avitaminosis	1.1%
1014	Aortopulmonary Septal Defect	1%
1015	Double Outlet Right Ventricle	1%
1016	Endocardial Cushion Defects	1%
1017	Myocardial bridging	1%
1018	Aorticopulmonary Septal Defect	1%
1019	Mandibulofacial Dysostosis	0.9%
1020	Romano-Ward Syndrome	0.9%
1021	Truncus Arteriosus, Persistent	0.9%
1022	Obesity, Abdominal	0.9%
1023	Goldenhar Syndrome	0.9%
1024	Arteriovenous fistula	0.8%
1025	Talipes	0.8%
1026	Pediatric Obesity	0.8%
1027	Congenital clubfoot	0.7%
1028	Vertical Talus	0.7%
1029	Ascorbic Acid Deficiency	0.7%
1030	Vitamin A Deficiency	0.7%
1031	Vitamin D Deficiency	0.7%
1032	Vitamin E Deficiency	0.7%
1033	Marasmus	0.7%
1034	Vitamin K Deficiency	0.6%
1035	Folic Acid Deficiency	0.5%
1036	Pellagra	0.5%
1037	Thiamine Deficiency	0.5%
1038	Vitamin B 12 Deficiency	0.5%
1039	Vitamin B 6 Deficiency	0.5%
1040	Pyridoxine Deficiency	0.5%
1041	Beriberi	0.4%
1042	Scurvy	0.4%
1043	Anemia, Pernicious	0.4%

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