MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Phocomelia

(UMLS:C0031575)

UMLS ID:: C0031575
MeSH ID:: D004480

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.660.585.350

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.585.350

Synonym(s)

Phocomelia

Congenital absence of proximal portion of limb

PHOCOMELIA

Phocomelia, NOS

Phocomelia, unspecified limb(s)

phocomelia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Clomiphene			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Arachnodactyly	47.5%
2	Polydactyly	47.5%
3	Brachydactyly	47.5%
4	Lower Extremity Deformities, Congenital	47.5%
5	Upper Extremity Deformities, Congenital	47.5%
6	Syndactyly	40.3%
7	Craniofacial Abnormalities	32.8%
8	Poland Syndrome	30%
9	Arthrogryposis	29.1%
10	Pectus excavatum	28.9%
11	Acrocephalosyndactylia	28.4%
12	Klippel-Feil Syndrome	28%
13	Synostosis	28%
14	Gastroschisis	26%
15	Craniosynostosis	25.4%
16	Brachycephaly	25.4%
17	Talipes	24%
18	Pectus carinatum	23.7%
19	Plagiocephaly	21.3%
20	Congenital clubfoot	20.7%
21	Vertical Talus	20.7%
22	Maxillofacial Abnormalities	19.4%
23	Holoprosencephaly	19.4%
24	Craniofacial Dysostosis	19%
25	Platybasia	18.7%
26	Rubinstein-Taybi Syndrome	18.2%
27	Abnormalities, Drug-Induced	16.9%
28	Situs Inversus	16.9%
29	Microcephaly	16.5%
30	Macrocephaly	16.5%
31	Antley-Bixler Syndrome Phenotype	14.2%
32	Beckwith-Wiedemann Syndrome	13.9%
33	Wolf-Hirschhorn Syndrome	13.9%
34	Noonan Syndrome	13.3%
35	Eye Abnormalities	13.3%
36	Cardiovascular Abnormalities	13.3%
37	Laryngomalacia	13.2%
38	Jaw Abnormalities	13.1%
39	Porencephaly	12.9%
40	Skin Abnormalities	12.8%
41	Lymphatic Abnormalities	12.8%
42	Congenital Microtia	12.8%
43	Congenital diaphragmatic hernia	12.5%
44	Mandibulofacial Dysostosis	11.9%
45	Goldenhar Syndrome	11.9%
46	Bone Diseases	11.8%
47	Fasciitis	11.8%
48	Foot Deformities	11.8%
49	Arthropathy	11.8%
50	Smith-Magenis syndrome	11.7%
51	Cri-du-Chat Syndrome	11.5%
52	Down Syndrome	11.5%
53	Trisomy 21	11.5%
54	Aicardi's syndrome	11.3%
55	Nail-Patella Syndrome	11.3%
56	Urogenital Abnormalities	10.6%
57	Genetic Diseases, Inborn	10.6%
58	Contracture	10.3%
59	Osteoarthropathy, Secondary Hypertrophic	10.3%
60	Fasciitis, Plantar	10.3%
61	Micrognathism	10%
62	Pierre Robin Syndrome	10%
63	Ectodermal Dysplasia	10%
64	Aplasia Cutis Congenita	10%
65	Prune Belly Syndrome	9.9%
66	Twins, Conjoined	9.9%
67	Waardenburg Syndrome	9.9%
68	Anencephaly	9.9%
69	Prader-Willi Syndrome	9.9%
70	Bronchomalacia	9.8%
71	Tracheomalacia	9.8%
72	CHARGE Syndrome	9.4%
73	Prognathism	9.4%
74	Jaw Diseases	9.2%
75	Cleft Palate	9.1%
76	Marfan Syndrome	9%
77	Retrognathia	8.9%
78	Cartilage Diseases	8.8%
79	Foot Diseases	8.8%
80	Myopathy	8.8%
81	Rheumatism	8.8%
82	Chondromalacia	8.8%
83	Dural Arteriovenous Fistula	8.3%
84	Dextrocardia	8.2%
85	Fibromyalgia	8.2%
86	Osteochondritis	8.2%
87	Polymyalgia Rheumatica	8.2%
88	Metatarsalgia	8.1%
89	Fetal Diseases	8%
90	Xeroderma	7.8%
91	Mobius Syndrome	7.8%
92	Gout	7.6%
93	Anophthalmos	7.6%
94	Anus, Imperforate	7.6%
95	Hydranencephaly	7.6%
96	Microphthalmos	7.6%
97	Multiple Epiphyseal Dysplasia	7.6%
98	Neural Tube Defects	7.6%
99	Osteochondrodysplasias	7.6%
100	Tethered Cord Syndrome	7.6%
101	Iniencephaly	7.6%
102	Craniorachischisis	7.6%
103	Exencephaly	7.6%
104	Septo-Optic Dysplasia	7.6%
105	Cortical Dysplasia	7.6%
106	Malformations of Cortical Development	7.6%
107	Anorectal Malformations	7.6%
108	Bloom Syndrome	7.4%
109	Cockayne Syndrome	7.4%
110	Kartagener Syndrome	7.4%
111	Abnormalities, Radiation-Induced	7.1%
112	Osteoarthritis, Spine	6.8%
113	Arthritis	6.7%
114	Bone Diseases, Developmental	6.7%
115	Bursitis	6.7%
116	Hyperostosis	6.7%
117	Joint Instability	6.7%
118	Myofascial Pain Syndromes	6.7%
119	Osteitis	6.7%
120	Osteitis Deformans	6.7%
121	Osteochondrosis	6.7%
122	Rhabdomyolysis	6.7%
123	Spinal Diseases	6.7%
124	Synovitis	6.7%
125	Joint laxity	6.7%
126	Polyarthritis	6.7%
127	Frozen shoulder	6.7%
128	Patellofemoral Pain Syndrome	6.7%
129	Rheumatic Fever	6.7%
130	Ischemic contracture	6.6%
131	Hip Contracture	6.6%
132	Periarthritis	6.6%
133	Polycystic Kidney Diseases	6.5%
134	Williams Syndrome	6.5%
135	Scimitar Syndrome	6.4%
136	Temporomandibular Joint Disorders	6.3%
137	Dwarfism	6.3%
138	Blepharophimosis	6.1%
139	Laryngostenosis	6.1%
140	Mouth Abnormalities	6.1%
141	Esophageal Atresia	6%
142	Intestinal Atresia	6%
143	Horseshoe Kidney	6%
144	Muscular Dystrophy	6%
145	Acrodermatitis	6%
146	Lymphangiectasis, Intestinal	6%
147	Gianotti-Crosti Syndrome	6%
148	Retinal Dysplasia	5.9%
149	Aniridia	5.8%
150	Cystic Fibrosis	5.8%
151	Osteoarthritis, Knee	5.7%
152	Epidermolysis Bullosa	5.7%
153	Ankylosing spondylitis	5.7%
154	Basal Cell Nevus Syndrome	5.7%
155	Rheumatoid Arthritis	5.6%
156	Juvenile arthritis	5.6%
157	Alstrom Syndrome	5.6%
158	Abdominal Cramps	5.6%
159	Amniotic Band Syndrome	5.6%
160	Asphyxia Neonatorum	5.6%
161	Infant, Premature, Diseases	5.6%
162	Infantile Colic	5.6%
163	Temporomandibular Joint Dysfunction Syndrome	5.6%
164	Fragile X Syndrome	5.5%
165	Osteogenesis Imperfecta	5.3%
166	Arthritis, Gouty	5.3%
167	Bone Diseases, Endocrine	5.3%
168	Gigantism	5.3%
169	Spinal Neoplasms	5.3%
170	Spondylitis	5.3%
171	Primary Ciliary Dyskinesia	5.3%
172	Smith-Lemli-Opitz Syndrome	5.3%
173	Choanal Atresia	5.1%
174	Tracheobronchomegaly	5.1%
175	Laryngocele	5.1%
176	Bone Diseases, Infectious	5.1%
177	Bone neoplasms	5.1%
178	Compartment syndromes	5.1%
179	Maxillary Diseases	5.1%
180	Osteopenia	5.1%
181	Tendinitis	5.1%
182	Tendinopathy	5.1%
183	Choledochal Cyst	5.1%
184	Hermaphroditism	5.1%
185	Disorders of Sex Development	5.1%
186	Ichthyosis, X-Linked	5.1%
187	Bone Resorption	5%
188	Hemarthrosis	5%
189	Myositis	5%
190	Tietze's Syndrome	5%
191	Isaacs syndrome	5%
192	Aseptic Necrosis of Bone	5%
193	Myotonic Disorders	5%
194	Cryptorchidism	5%
195	Hypospadias	5%
196	Central Nervous System Cysts	5%
197	Dandy-Walker Syndrome	5%
198	Ectopia Cordis	4.9%
199	Meningomyelocele	4.9%
200	Spina Bifida	4.9%
201	POEMS Syndrome	4.9%
202	Single umbilical artery	4.9%
203	Muscular Dystrophy, Duchenne	4.9%
204	Meconium Aspiration Syndrome	4.9%
205	Congenital Hypothyroidism	4.8%
206	Myotonic Dystrophy	4.7%
207	Arthritis, Psoriatic	4.7%
208	Classical Lissencephalies and Subcortical Band Heterotopias	4.7%
209	Rheumatoid Nodule	4.6%
210	Turner Syndrome	4.5%
211	Spondylarthropathies	4.5%
212	Pseudoxanthoma Elasticum	4.4%
213	Neoplastic Syndromes, Hereditary	4.4%
214	Familial Periodic Paralysis	4.4%
215	Ainhum	4.4%
216	Bunion	4.4%
217	Dysostoses	4.4%
218	Fibrodysplasia Ossificans Progressiva	4.4%
219	Myoglobinuria	4.4%
220	Myositis Ossificans	4.4%
221	Spinal Stenosis	4.4%
222	Spondylosis	4.4%
223	Tenosynovitis	4.4%
224	Intervertebral Disc Degeneration	4.4%
225	Sacroiliitis	4.4%
226	Polycystic Kidney, Autosomal Dominant	4.3%
227	Bladder Exstrophy	4.3%
228	Epispadias	4.3%
229	Multicystic Dysplastic Kidney	4.3%
230	Anemia, Neonatal	4.2%
231	Pelger-Huet Anomaly	4.2%
232	Persistent Fetal Circulation Syndrome	4.2%
233	Werner Syndrome	4.2%
234	Myasthenic Syndromes, Congenital	4.2%
235	Arthritis, Reactive	4.2%
236	Umbilical hernia	4.1%
237	Medial Tibial Stress Syndrome	4.1%
238	Mitochondrial Myopathies	4%
239	Xeroderma Pigmentosum	4%
240	Muscle Cramp	4%
241	Eosinophilia-Myalgia Syndrome	4%
242	Sjogren-Larsson Syndrome	4%
243	Muscle Rigidity	4%
244	Muscle Spasticity	4%
245	Cogwheel Rigidity	4%
246	Nuchal Rigidity	4%
247	Aortic coarctation	3.9%
248	Cor Triatriatum	3.9%
249	Coronary Vessel Anomalies	3.9%
250	Dental Enamel Hypoplasia	3.9%
251	Patent ductus arteriosus	3.9%
252	Ebstein Anomaly	3.9%
253	Heart Septal Defects	3.9%
254	Hypodontia	3.9%
255	Macrostomia	3.9%
256	Meningocele	3.9%
257	Microstomia	3.9%
258	Tetralogy of Fallot	3.9%
259	Transposition of Great Vessels	3.9%
260	Hypoplastic Left Heart Syndrome	3.9%
261	May-Thurner Syndrome	3.9%
262	Encephalocele	3.9%
263	Welander Distal Myopathy	3.9%
264	Discitis	3.9%
265	Wolff-Parkinson-White Syndrome	3.9%
266	Kallmann Syndrome	3.9%
267	Myotonia Congenita	3.8%
268	Felty Syndrome	3.8%
269	Klinefelter Syndrome	3.8%
270	Charcot-Marie-Tooth Disease	3.7%
271	Dermal Sinus	3.6%
272	Spina Bifida Cystica	3.6%
273	Spina Bifida Occulta	3.6%
274	Lissencephaly	3.6%
275	Polymicrogyria	3.6%
276	Pachygyria	3.6%
277	Schizencephaly	3.6%
278	Periventricular Nodular Heterotopia	3.6%
279	Zellweger Syndrome	3.5%
280	Chronic Fatigue Syndrome	3.5%
281	Neonatal Abstinence Syndrome	3.4%
282	Hyperkeratosis, Epidermolytic	3.4%
283	Giant Cell Epulis	3.4%
284	Muscle Weakness	3.4%
285	Arthritis, Infectious	3.4%
286	Fetal Growth Retardation	3.4%
287	Musculoskeletal Pain	3.3%
288	Fetal Hypoxia	3.3%
289	Congenital nystagmus	3.3%
290	Fetal Alcohol Spectrum Disorders	3.3%
291	Anterior Compartment Syndrome	3.3%
292	Osteomyelitis	3.3%
293	Osteoporosis	3.3%
294	Periostitis	3.3%
295	Enthesopathy	3.3%
296	Bone Demineralization, Pathologic	3.3%
297	Post-Traumatic Osteoporosis	3.3%
298	Arthritis, Experimental	3.3%
299	Abdominal Compartment Syndrome	3.3%
300	Toxoplasmosis, Congenital	3.3%
301	Arthralgia	3.3%
302	Long QT Syndrome	3.3%
303	Familial Mediterranean Fever	3.3%
304	Polyarthralgia	3.3%
305	Tricuspid Atresia	3.3%
306	Arrhythmogenic Right Ventricular Dysplasia	3.3%
307	Syphilis, Congenital	3.3%
308	Anemia, Sickle Cell	3.3%
309	Thalassemia	3.3%
310	Alveolar Bone Loss	3.3%
311	Femur Head Necrosis	3.3%
312	Gonadal Dysgenesis	3.3%
313	Polymyositis	3.3%
314	Adrenogenital Syndrome	3.3%
315	Ovotesticular Disorders of Sex Development	3.3%
316	Osteolysis	3.3%
317	Rheumatoid Vasculitis	3.3%
318	Chondrodysplasia Punctata	3.3%
319	Enchondromatosis	3.3%
320	Lordosis	3.3%
321	Osteosclerosis	3.3%
322	Spondylolysis	3.3%
323	kyphosis	3.3%
324	Kashin-Beck Disease	3.3%
325	Tuberculosis, Spinal	3.2%
326	Tuberous Sclerosis	3.2%
327	Refsum Disease	3%
328	Hypokalemic periodic paralysis	3%
329	Albinism	2.9%
330	Aortopulmonary Septal Defect	2.9%
331	Double Outlet Right Ventricle	2.9%
332	Endocardial Cushion Defects	2.9%
333	Myocardial bridging	2.9%
334	Aorticopulmonary Septal Defect	2.9%
335	Hyperandrogenism	2.9%
336	Sicca Syndrome	2.9%
337	Sjogren's Syndrome	2.9%
338	Eosinophilic Granuloma	2.8%
339	Autoimmune Lymphoproliferative Syndrome	2.8%
340	Myalgia	2.8%
341	Pseudohypoparathyroidism	2.8%
342	Congenital Hyperinsulinism	2.8%
343	Chorioamnionitis	2.8%
344	Angioedemas, Hereditary	2.7%
345	Hip Dislocation	2.7%
346	Shoulder Dislocation	2.7%
347	Hip Dysplasia	2.7%
348	Melorheostosis	2.7%
349	Osteopetrosis	2.7%
350	Spondylolisthesis	2.7%
351	Orbital Myositis	2.7%
352	Dupuytren Contracture	2.7%
353	Palatal Neoplasms	2.7%
354	Pyomyositis	2.6%
355	Acromegaly	2.6%
356	Joint Tuberculosis	2.6%
357	Tuberculosis, Osteoarticular	2.6%
358	Bone Tuberculosis	2.6%
359	Rett Syndrome	2.6%
360	Paralysis, Obstetric	2.5%
361	Retinopathy of Prematurity	2.5%
362	Amino Acid Metabolism, Inborn Errors	2.5%
363	Carbohydrate Metabolism, Inborn Errors	2.5%
364	Metal Metabolism, Inborn Errors	2.5%
365	Progeria	2.5%
366	Lysosomal Storage Diseases	2.5%
367	Cytochrome-c Oxidase Deficiency	2.5%
368	Peroxisomal Disorders	2.5%
369	Wiskott-Aldrich Syndrome	2.5%
370	Bronchopulmonary Dysplasia	2.5%
371	Osteoporosis, Postmenopausal	2.4%
372	Romano-Ward Syndrome	2.4%
373	Truncus Arteriosus, Persistent	2.4%
374	Mucopolysaccharidosis II	2.2%
375	Rickets	2.2%
376	Menkes Kinky Hair Syndrome	2.2%
377	Shoulder Pain	2.2%
378	Sickle Cell Trait	2.2%
379	Neuronal Ceroid-Lipofuscinoses	2.1%
380	Ophthalmia Neonatorum	2%
381	Respiratory Distress Syndrome, Newborn	2%
382	Cutis Laxa	2%
383	Retinitis Pigmentosa	2%
384	Pigmentary retinopathy	2%
385	Porokeratosis	2%
386	Keratoderma, Palmoplantar	2%
387	Chronic granulomatous disease	2%
388	Mastoiditis	1.9%
389	Petrositis	1.9%
390	Mitochondrial Encephalomyopathies	1.9%
391	Ataxia Telangiectasia	1.9%
392	Arteriovenous fistula	1.8%
393	Amyloid Neuropathies, Familial	1.8%
394	Hepatolenticular Degeneration	1.8%
395	Adrenoleukodystrophy	1.7%
396	Duane Retraction Syndrome	1.7%
397	Porphyrias, Hepatic	1.7%
398	Dermatomyositis	1.7%
399	Acute Chest Syndrome	1.7%
400	Peutz-Jeghers Syndrome	1.7%
401	Hydrops Fetalis	1.6%
402	Thrombasthenia	1.6%
403	Antithrombin III Deficiency	1.6%
404	Protein C Deficiency	1.6%
405	Brain Diseases, Metabolic, Inborn	1.6%
406	Afibrinogenemia	1.6%
407	Dystonia Musculorum Deformans	1.6%
408	Factor VII Deficiency	1.6%
409	Factor X Deficiency	1.6%
410	Factor XII Deficiency	1.6%
411	Hemophilia A	1.6%
412	Leukomalacia, Periventricular	1.6%
413	Activated Protein C Resistance	1.6%
414	Factor II deficiency	1.6%
415	Factor VIII Deficiency	1.6%
416	Factor V deficiency	1.6%
417	Factor XI Deficiency	1.6%
418	Hypoprothrombinemias	1.6%
419	Fanconi Anemia	1.6%
420	Nesidioblastosis	1.6%
421	Alkaptonuria	1.6%
422	Glycogen Storage Disease	1.6%
423	Hypophosphatasia	1.6%
424	Propionic acidemia	1.6%
425	Dihydropyrimidine Dehydrogenase Deficiency	1.6%
426	Cystinosis	1.6%
427	Lafora Disease	1.6%
428	Unverricht-Lundborg Syndrome	1.6%
429	Anemia, Diamond-Blackfan	1.6%
430	Galactosemias	1.6%
431	Urea Cycle Disorders, Inborn	1.6%
432	Tyrosinemias	1.6%
433	Osteomalacia	1.6%
434	Fabry Disease	1.5%
435	Denys-Drash Syndrome	1.5%
436	Multiple Endocrine Neoplasia	1.5%
437	MELAS Syndrome	1.5%
438	Canavan Disease	1.5%
439	Alexander Disease	1.5%
440	Optic Atrophy, Hereditary, Leber	1.4%
441	Glycogen storage disease type II	1.4%
442	Hyperphosphaturia	1.4%
443	Dermatitis, Atopic	1.4%
444	Mucopolysaccharidosis III	1.4%
445	Hyaline Membrane Disease	1.3%
446	Hypolipoproteinemias	1.3%
447	Papillon-Lefevre Disease	1.3%
448	Hyperlipidemia, Familial Combined	1.3%
449	Hyperlipoproteinemia Type III	1.3%
450	Homocystinuria	1.3%
451	Leigh Disease	1.3%
452	Familial Hypophosphatemic Rickets	1.3%
453	Kernicterus	1.3%
454	Behcet Syndrome	1.2%
455	Glycogen Storage Disease Type I	1.2%
456	Glycogen Storage Disease Type V	1.2%
457	Radicular Cyst	1.2%
458	Nose Neoplasms	1.1%
459	Huntington Disease	1.1%
460	Lactose Intolerance	1.1%
461	Variegate Porphyria	1.1%
462	Acute intermittent porphyria	1.1%
463	Porphyria Cutanea Tarda	1.1%
464	Hyperhomocysteinemia	1.1%
465	Gaucher Disease	1.1%
466	Renal Osteodystrophy	1.1%
467	Renal rickets	1.1%
468	Renal Aminoacidurias	1.1%
469	Fanconi Syndrome	1.1%
470	Pseudohypoaldosteronism	1.1%
471	Liddle Syndrome	1.1%
472	Hyperlipoproteinemia Type IV	1.1%
473	Hyperlipoproteinemia Type V	1.1%
474	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.1%
475	Nephroblastoma	1%
476	Hypoalphalipoproteinemias	1%
477	Multiple Endocrine Neoplasia Type 1	0.9%
478	Friedreich Ataxia	0.9%
479	Renal tubular acidosis	0.9%
480	Tay-Sachs Disease	0.9%
481	Niemann-Pick Disease, Type C	0.9%
482	Adenomatous Polyposis Coli	0.9%
483	Kearns-Sayre syndrome	0.8%
484	Cystinuria	0.8%
485	Glycosuria, Renal	0.7%

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