MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Urea Cycle Disorders, Inborn

(UMLS:C0154246)

Definition:: Rare congenital metabolism disorders of the urea cycle. The disorders are due to mutations that result in complete (neonatal onset) or partial (childhood or adult onset) inactivity of an enzyme, involved in the urea cycle. Neonatal onset results in clinical features that include irritability, vomiting, lethargy, seizures, NEONATAL HYPOTONIA; RESPIRATORY ALKALOSIS; HYPERAMMONEMIA; coma, and death. Survivors of the neonatal onset and childhood/adult onset disorders share common risks for ENCEPHALOPATHIES, METABOLIC, INBORN; and RESPIRATORY ALKALOSIS due to HYPERAMMONEMIA.
UMLS ID:: C0154246
MeSH ID:: D056806

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.937

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.100.940|C16.320.565.189.937

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.937|C18.452.648.100.940|C18.452.648.189.937

Synonym(s)

Urea Cycle Disorders, Inborn

Disorder of Urea Cycle Metabolism

Disorder of the urea cycle metabolism

Disorder of the urea cycle metabolism, NOS

Disorder of urea cycle

Disorder of urea cycle metabolism, unspecified

Disorders of urea cycle metabolism

Inborn Urea Cycle Disorder

Urea Cycle Metabolism Disorder

10.

Urea cycle disorder

11.

cycle disorders urea

12.

disorder of the urea cycle metabolism

13.

inborn urea cycle disorder

14.

metabolic disorder; urea cycle

15.

of urea cycle disorder

16.

urea cycle disorder

17.

urea cycle; metabolic disorder

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Sodium Benzoate		3374991 6636107 7078580	CTD
2	phenylacetic acid		3374991	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Tyrosinemias	70%
2	Galactosemias	61.4%
3	Leigh Disease	59.5%
4	Homocystinuria	59.1%
5	Adrenoleukodystrophy	56.8%
6	Hepatolenticular Degeneration	51.2%
7	Menkes Kinky Hair Syndrome	51.2%
8	Glycogen storage disease type II	49.7%
9	Zellweger Syndrome	47.8%
10	Refsum Disease	47.4%
11	Gaucher Disease	41.4%
12	MELAS Syndrome	40.3%
13	Hyperhomocysteinemia	40.2%
14	Smith-Lemli-Opitz Syndrome	39.8%
15	Fabry Disease	39%
16	Alkaptonuria	37.8%
17	Propionic acidemia	37.8%
18	Carbohydrate Metabolism, Inborn Errors	37.7%
19	Metal Metabolism, Inborn Errors	37.7%
20	Progeria	37.7%
21	Lysosomal Storage Diseases	37.7%
22	Peroxisomal Disorders	37.7%
23	Canavan Disease	35.8%
24	Alexander Disease	35.8%
25	Hyperphosphaturia	35.1%
26	Tay-Sachs Disease	34.8%
27	Niemann-Pick Disease, Type C	34.7%
28	Pseudohypoparathyroidism	34.3%
29	Albinism	32.7%
30	Lactose Intolerance	28.8%
31	Hypolipoproteinemias	28.6%
32	Cytochrome-c Oxidase Deficiency	28%
33	Amyloid Neuropathies, Familial	27.6%
34	Hyperlipoproteinemia Type IV	27.1%
35	Hyperlipoproteinemia Type V	27.1%
36	Mucopolysaccharidosis III	27.1%
37	Mucopolysaccharidosis II	27%
38	Hyperlipidemia, Familial Combined	27%
39	Familial Hypophosphatemic Rickets	26.6%
40	Hyperlipoproteinemia Type III	26.1%
41	Neuronal Ceroid-Lipofuscinoses	25%
42	Glycogen Storage Disease	24.9%
43	Hypophosphatasia	24.9%
44	Dihydropyrimidine Dehydrogenase Deficiency	24.9%
45	Cystinosis	24.9%
46	Wasting Syndrome	24.7%
47	Myelinolysis, Central Pontine	24%
48	Mitochondrial Encephalomyopathies	23.9%
49	Ichthyosis, X-Linked	23.4%
50	Renal tubular acidosis	23.4%
51	Werner Syndrome	23.3%
52	Brain Diseases, Metabolic, Inborn	22.4%
53	Reye Syndrome	22.2%
54	Hepatic Encephalopathy	22.1%
55	Hypercalcemia	21.9%
56	Hypocalcemia	21.9%
57	Milk-Alkali Syndrome	21.9%
58	Urea Cycle Disorders, Inborn	21.4%
59	Carbamoyl-Phosphate Synthase I Deficiency Disease	21.4%
60	Hypoalphalipoproteinemias	21.4%
61	Familial Periodic Paralysis	21%
62	Acid-Base Imbalance	21%
63	Calcium Metabolism Disorders	21%
64	Iron Metabolism Disorders	21%
65	Phosphorus Metabolism Disorders	21%
66	Water-Electrolyte Imbalance	21%
67	Lipid Metabolism Disorders	21%
68	Mitochondrial Diseases	21%
69	Glucose Metabolism Disorders	21%
70	Amino Acid Metabolism, Inborn Errors	20.7%
71	Sjogren-Larsson Syndrome	20%
72	Renal Aminoacidurias	19.9%
73	Fanconi Syndrome	19.9%
74	Pseudohypoaldosteronism	19.9%
75	Liddle Syndrome	19.9%
76	Glycosuria, Renal	19.8%
77	Lipodystrophy	19.5%
78	Cockayne Syndrome	19.5%
79	Antley-Bixler Syndrome Phenotype	19.4%
80	Wernicke Encephalopathy	19.1%
81	Rickets	18.7%
82	Glycogen Storage Disease Type I	18.6%
83	Glycogen Storage Disease Type V	18.6%
84	Osteopenia	18.6%
85	Kernicterus	18.5%
86	Gout	18.4%
87	Ataxia Telangiectasia	17.1%
88	Hypokalemic periodic paralysis	15.5%
89	Friedreich Ataxia	15.2%
90	Congenital Hyperinsulinism	15.1%
91	Cystinuria	14.9%
92	Porphyrias, Hepatic	14.8%
93	Fanconi Anemia	14.5%
94	Aicardi's syndrome	14.4%
95	Arthritis, Gouty	13.6%
96	Cystic Fibrosis	13.4%
97	Bloom Syndrome	13.4%
98	Optic Atrophy, Hereditary, Leber	13.3%
99	Myasthenic Syndromes, Congenital	13.3%
100	CHARGE Syndrome	13.1%
101	Nutrition Disorders	12.8%
102	Osteomalacia	12.6%
103	Neoplastic Syndromes, Hereditary	12.6%
104	Acidosis	12.5%
105	Alkalosis	12.5%
106	Amyloidosis	12.5%
107	Calcinosis	12.5%
108	Hyperglycemia	12.5%
109	Hyperinsulinism	12.5%
110	Hyperkalemia	12.5%
111	Hypernatremia	12.5%
112	Hypoglycemia	12.5%
113	Hypokalemia	12.5%
114	Hyponatremia	12.5%
115	Xanthomatosis	12.5%
116	Hypophosphatemia	12.5%
117	Metabolic acidosis	12.5%
118	Dyslipidemias	12.5%
119	Iron Overload	12.5%
120	Xanthoma	12.5%
121	Brain Diseases, Metabolic	12.3%
122	Multiple Epiphyseal Dysplasia	12.3%
123	Osteochondrodysplasias	12.3%
124	Pelger-Huet Anomaly	12.3%
125	Xeroderma Pigmentosum	12%
126	Fragile X Syndrome	12%
127	Muscular Dystrophy, Duchenne	12%
128	Nail-Patella Syndrome	11.9%
129	Alstrom Syndrome	11.9%
130	Anemia, Sickle Cell	11.7%
131	Thalassemia	11.7%
132	Dystonia Musculorum Deformans	11.5%
133	Muscular Dystrophy	11.4%
134	Smith-Magenis syndrome	11.3%
135	Diabetic Ketoacidosis	11.3%
136	Diabetes Mellitus	11.2%
137	Dwarfism	11.2%
138	Huntington Disease	11.1%
139	Prader-Willi Syndrome	11.1%
140	Dehydration	11%
141	Lipomatosis	11%
142	Water Intoxication	11%
143	Marchiafava-Bignami Disease	11%
144	Achlorhydria	11%
145	Osteoporosis	11%
146	Bone Demineralization, Pathologic	11%
147	Post-Traumatic Osteoporosis	11%
148	Celiac Disease	10.9%
149	Sprue, Tropical	10.9%
150	Steatorrhea	10.9%
151	Sprue	10.9%
152	Osteogenesis Imperfecta	10.9%
153	Beckwith-Wiedemann Syndrome	10.8%
154	Wolf-Hirschhorn Syndrome	10.8%
155	Mitochondrial Myopathies	10.7%
156	Nesidioblastosis	10.7%
157	Kartagener Syndrome	10.6%
158	HIV Wasting Syndrome	10.6%
159	Tuberous Sclerosis	10.5%
160	Dandy-Walker Syndrome	10.3%
161	Myotonic Dystrophy	10.2%
162	Cri-du-Chat Syndrome	10.2%
163	Down Syndrome	10.2%
164	Trisomy 21	10.2%
165	Marfan Syndrome	10.2%
166	Holoprosencephaly	10.2%
167	Autoimmune Lymphoproliferative Syndrome	9.9%
168	Amyotrophic Lateral Sclerosis	9.8%
169	Renal Osteodystrophy	9.8%
170	Renal rickets	9.8%
171	Angioedemas, Hereditary	9.8%
172	Wiskott-Aldrich Syndrome	9.8%
173	Glycosuria	9.7%
174	Meningoencephalitis	9.7%
175	Variegate Porphyria	9.7%
176	Acute intermittent porphyria	9.7%
177	Porphyria Cutanea Tarda	9.7%
178	HIV-Associated Lipodystrophy Syndrome	9.7%
179	Lafora Disease	9.4%
180	Unverricht-Lundborg Syndrome	9.4%
181	Dementia, Vascular	9.1%
182	Kallmann Syndrome	8.9%
183	Rett Syndrome	8.9%
184	Ectodermal Dysplasia	8.9%
185	Aplasia Cutis Congenita	8.9%
186	Subdural Effusion	8.9%
187	Rubinstein-Taybi Syndrome	8.9%
188	Necrobiosis Lipoidica Diabeticorum	8.8%
189	Leukomalacia, Periventricular	8.8%
190	Kearns-Sayre syndrome	8.7%
191	Encephalomyelitis	8.6%
192	Deformity	8.6%
193	Familial Mediterranean Fever	8.3%
194	Pneumocephalus	8.3%
195	Cerebral Amyloid Angiopathy	8.3%
196	Acidosis, Lactic	8.3%
197	Calciphylaxis	8.3%
198	Hemosiderosis	8.3%
199	Ketosis	8.3%
200	Ketonuria	8.3%
201	Ketoacidosis	8.3%
202	Ketonemia	8.3%
203	Vascular calcification	8.3%
204	Williams Syndrome	8.3%
205	Brain Abscess	8.2%
206	Multiple System Atrophy	8.2%
207	Akinetic Mutism	8.1%
208	Anoxic Encephalopathy	8.1%
209	Basal Ganglia Diseases	8.1%
210	Brain Damage, Chronic	8.1%
211	Cerebellar Diseases	8.1%
212	Encephalitis	8.1%
213	Encephalomalacia	8.1%
214	Epilepsy	8.1%
215	Hydrocephalus	8.1%
216	Congenital Hydrocephalus	8.1%
217	Hypothalamic Diseases	8.1%
218	Thalamic Diseases	8.1%
219	Intracranial Hypertension	8.1%
220	Aura	8.1%
221	Leukoencephalopathy	8.1%
222	Neuroaxonal Dystrophies	8.1%
223	Headache Disorders	8.1%
224	Intracranial Hypotension	8.1%
225	Brain Edema	8.1%
226	Brain Hypoxia	8.1%
227	Aqueductal Stenosis	8.1%
228	Lewy Body Disease	7.8%
229	Polycystic Kidney Diseases	7.8%
230	Sickle Cell Trait	7.7%
231	Fetal Diseases	7.5%
232	Basal Ganglia Cerebrovascular Disease	7.5%
233	Primary Ciliary Dyskinesia	7.4%
234	Tetany	7.4%
235	Acidosis, Respiratory	7.3%
236	Adiposis Dolorosa	7.3%
237	Alkalosis, Respiratory	7.3%
238	Parkinsonian Disorders	7.3%
239	Retinal Dysplasia	7.3%
240	Epilepsy, Post-Traumatic	7.2%
241	Insulin Resistance	7.2%
242	Osteoporosis, Postmenopausal	7.2%
243	Brain Injuries	7.2%
244	Aniridia	7.2%
245	Brain Neoplasms	7.2%
246	Cerebrovascular Disorders	7.2%
247	Cerebrovascular Insufficiency	7.2%
248	Dementia	7.2%
249	Myotonia Congenita	7.2%
250	Epidermolysis Bullosa	7.1%
251	Frontotemporal dementia	7.1%
252	Posterior Leukoencephalopathy Syndrome	7%
253	Posterior reversible encephalopathy syndrome	7%
254	Child Nutrition Disorders	7%
255	Hypervitaminosis A	7%
256	Infant Nutrition Disorders	7%
257	Malnutrition	7%
258	Welander Distal Myopathy	6.8%
259	Duane Retraction Syndrome	6.8%
260	Ocular Motility Disorders	6.8%
261	Cyclophoria	6.8%
262	Gestational Diabetes	6.6%
263	Latent Autoimmune Diabetes in Adults	6.6%
264	Brain Death	6.6%
265	Cutis Laxa	6.6%
266	Acute Chest Syndrome	6.5%
267	Diabetes Mellitus, Experimental	6.5%
268	Retinitis Pigmentosa	6.5%
269	Pigmentary retinopathy	6.5%
270	Porokeratosis	6.5%
271	Keratoderma, Palmoplantar	6.5%
272	Chronic granulomatous disease	6.5%
273	Nephrocalcinosis	6.5%
274	Epidural Abscess	6.3%
275	Meningitis	6.3%
276	Movement Disorders	6.3%
277	Pachymeningitis	6.3%
278	Spinal Cord Diseases	6.3%
279	Vascular Headaches	6.3%
280	Hypoxia-Ischemia, Brain	6.2%
281	Hypercholesterolemia	6.2%
282	Hyperlipoproteinemias	6.2%
283	Hypertriglyceridemia	6.2%
284	Amblyopia	6.2%
285	Charcot-Marie-Tooth Disease	6.2%
286	Myelitis	6.1%
287	Mobius Syndrome	6.1%
288	Pseudoxanthoma Elasticum	6.1%
289	Meconium Aspiration Syndrome	6.1%
290	Meige Syndrome	6%
291	Cerebral Ventriculitis	6%
292	Subacute Combined Degeneration	5.9%
293	Cerebellar Neoplasms	5.9%
294	Progressive supranuclear palsy	5.9%
295	Peutz-Jeghers Syndrome	5.9%
296	Thrombasthenia	5.9%
297	Primary amyloidosis	5.9%
298	Antithrombin III Deficiency	5.9%
299	Protein C Deficiency	5.9%
300	Afibrinogenemia	5.8%
301	Factor VII Deficiency	5.8%
302	Factor X Deficiency	5.8%
303	Factor XII Deficiency	5.8%
304	Hemophilia A	5.8%
305	Activated Protein C Resistance	5.8%
306	Factor II deficiency	5.8%
307	Factor VIII Deficiency	5.8%
308	Factor V deficiency	5.8%
309	Factor XI Deficiency	5.8%
310	Hypoprothrombinemias	5.8%
311	Classical Lissencephalies and Subcortical Band Heterotopias	5.8%
312	Anemia, Diamond-Blackfan	5.8%
313	Parkinson Disease	5.8%
314	Leukoencephalopathy, Progressive Multifocal	5.8%
315	Central Nervous System Infection	5.7%
316	Myoclonic Epilepsy	5.6%
317	Epilepsy, Temporal Lobe	5.6%
318	Epilepsy, Rolandic	5.6%
319	Benign Rolandic Epilepsy	5.6%
320	Stiff-Person Syndrome	5.5%
321	Multiple Endocrine Neoplasia	5.4%
322	Neuroleptic Malignant Syndrome	5.4%
323	Amnesia, Transient Global	5.4%
324	Lupus Vasculitis, Central Nervous System	5.4%
325	Creutzfeldt-Jakob disease	5.4%
326	Congenital Hypothyroidism	5.4%
327	Dermatitis, Atopic	5.3%
328	Xeroderma	5.3%
329	Basal Cell Nevus Syndrome	5.2%
330	Limbic Encephalitis	5.2%
331	Polycystic Kidney, Autosomal Dominant	5.1%
332	Basal Ganglia Hemorrhage	5.1%
333	Hyperkeratosis, Epidermolytic	5.1%
334	Striatonigral Degeneration	5%
335	Prion Diseases	4.9%
336	Behcet Syndrome	4.9%
337	CREST Syndrome	4.8%
338	Cerebral Palsy	4.8%
339	Epilepsies, Partial	4.8%
340	Epilepsy, Generalized	4.8%
341	Pseudotumor Cerebri	4.8%
342	Hypertensive Encephalopathy	4.8%
343	Simple Partial Seizures	4.8%
344	Epilepsy, Reflex	4.8%
345	Headache Disorders, Primary	4.8%
346	Headache Disorders, Secondary	4.8%
347	Medication overuse headache	4.8%
348	Dural Arteriovenous Fistula	4.7%
349	Toxoplasmosis, Congenital	4.7%
350	Presenile dementia	4.7%
351	Senile dementia	4.7%
352	Leukoencephalitis, Acute Hemorrhagic	4.7%
353	Abdominal Cramps	4.7%
354	Abnormalities, Drug-Induced	4.7%
355	Amniotic Band Syndrome	4.7%
356	Asphyxia Neonatorum	4.7%
357	Infant, Premature, Diseases	4.7%
358	Situs Inversus	4.7%
359	Infantile Colic	4.7%
360	Pituitary Adenoma	4.6%
361	Pituitary Neoplasms	4.6%
362	Brain Hemorrhage, Traumatic	4.6%
363	Shy-Drager Syndrome	4.6%
364	Pituitary Apoplexy	4.5%
365	Spinal Muscular Atrophy	4.5%
366	Progressive Muscular Atrophy	4.5%
367	Anencephaly	4.5%
368	Brain Infarction	4.5%
369	Toxoplasmosis, Cerebral	4.5%
370	Vasculitis, Central Nervous System	4.5%
371	Spinal Cord Injuries	4.5%
372	Carotid Artery Injuries	4.4%
373	Poliomyelitis	4.4%
374	Asterixis	4.4%
375	Ballismus	4.4%
376	Pituitary Diseases	4.3%
377	Ophthalmoplegic Migraine	4.3%
378	Meningitis, Bacterial	4.3%
379	Meningitis, Fungal	4.3%
380	Hydranencephaly	4.3%
381	Neural Tube Defects	4.3%
382	Tethered Cord Syndrome	4.3%
383	Iniencephaly	4.3%
384	Craniorachischisis	4.3%
385	Exencephaly	4.3%
386	Septo-Optic Dysplasia	4.3%
387	Cortical Dysplasia	4.3%
388	Malformations of Cortical Development	4.3%
389	Papillon-Lefevre Disease	4.3%
390	Brain Injuries, Diffuse	4.3%
391	Traumatic Brain Injury	4.3%
392	Cerebellar Ataxia	4.3%
393	Supratentorial Neoplasms	4.3%
394	Central Nervous System Cysts	4.3%
395	Carotid Artery Diseases	4.2%
396	Brain Ischemia	4.2%
397	Cerebrovascular accident	4.2%
398	Kluver-Bucy Syndrome	4.2%
399	Vasospasm, Intracranial	4.2%
400	Intracranial Arterial Diseases	4.2%
401	Miller Fisher Syndrome	4.2%
402	Paraneoplastic Cerebellar Degeneration	4.2%
403	Juvenile Myoclonic Epilepsy	4.2%
404	Myoclonic Epilepsies, Progressive	4.2%
405	Eye Abnormalities	4.2%
406	Cardiovascular Abnormalities	4.2%
407	Nephroblastoma	4.2%
408	Congenital nystagmus	4.2%
409	Deficiency Diseases	4.2%
410	Starvation	4.2%
411	Refeeding Syndrome	4.2%
412	MPTP Poisoning	4.1%
413	Skin Abnormalities	4.1%
414	Lymphatic Abnormalities	4.1%
415	Congenital Microtia	4.1%
416	Persistent Vegetative State	4.1%
417	Anemia, Neonatal	4.1%
418	Persistent Fetal Circulation Syndrome	4.1%
419	Congenital diaphragmatic hernia	4.1%
420	Umbilical hernia	4.1%
421	Chronic Fatigue Syndrome	4%
422	Cranial nerve diseases	4%
423	Demyelinating Diseases	4%
424	Demyelination	4%
425	Neuromuscular Diseases	4%
426	Chronobiology Disorders	4%
427	Putaminal Hemorrhage	3.9%
428	Encephalomyelitis, Acute Disseminated	3.9%
429	Adenomatous Polyposis Coli	3.9%
430	Myelitis, Transverse	3.8%
431	Intracranial Embolism and Thrombosis	3.8%
432	Hydrops Fetalis	3.8%
433	Restless Legs Syndrome	3.8%
434	Urogenital Abnormalities	3.8%
435	Turner Syndrome	3.7%
436	Infarction, Middle Cerebral Artery	3.7%
437	Infarction, Anterior Cerebral Artery	3.7%
438	Infarction, Posterior Cerebral Artery	3.7%
439	Motor Neuron Disease	3.7%
440	Klinefelter Syndrome	3.7%
441	Neonatal Abstinence Syndrome	3.7%
442	Fetal Growth Retardation	3.6%
443	Fetal Hypoxia	3.6%
444	Fetal Alcohol Spectrum Disorders	3.6%
445	Trauma, Nervous System	3.6%
446	Spinal Cord Neoplasms	3.6%
447	Syphilis, Congenital	3.6%
448	Akathisia, Drug-Induced	3.6%
449	Moyamoya Disease	3.6%
450	Nervous System Neoplasms	3.6%
451	Neurologic Manifestations	3.6%
452	Neurotoxicity Syndromes	3.6%
453	Multiple Endocrine Neoplasia Type 1	3.5%
454	Opsoclonus-Myoclonus Syndrome	3.5%
455	Arachnoiditis	3.5%
456	Aseptic Meningitis	3.5%
457	Syringomyelia	3.5%
458	Essential Tremor	3.5%
459	Familial Tremor	3.5%
460	Pneumorrhachis	3.5%
461	Writer's Cramp	3.5%
462	Polyradiculoneuropathy	3.5%
463	Polyradiculoneuritis	3.5%
464	Cerebral Infarction	3.4%
465	Brain Stem Infarctions	3.4%
466	Chorioamnionitis	3.3%
467	Maxillofacial Abnormalities	3.3%
468	Dextrocardia	3.3%
469	Auditory Perceptual Disorders	3.2%
470	Sleep Wake Disorders	3.2%
471	Post-Traumatic Headache	3.2%
472	Tension Headache	3.2%
473	Epilepsy, Complex Partial	3.2%
474	Migraine Disorders	3.2%
475	Abdominal Migraine	3.2%
476	Status Migrainosus	3.2%
477	Cervicogenic Headache	3.2%
478	Dyskinesia, Drug-Induced	3.2%
479	AIDS Dementia Complex	3.1%
480	Central Nervous System Fungal Infections	3.1%
481	Conus Medullaris Syndrome	3.1%
482	Spinal Cord Vascular Diseases	3.1%
483	Tuberculosis, Meningeal	3.1%
484	Abnormalities, Radiation-Induced	3%
485	Subarachnoid Hemorrhage, Traumatic	3%
486	Carotid Artery, Internal, Dissection	3%
487	Obesity	2.9%
488	Autonomic Dysreflexia	2.9%
489	Complex Regional Pain Syndromes	2.9%
490	Diffuse Axonal Injury	2.8%
491	Empty Sella Syndrome	2.8%
492	Hyperpituitarism	2.8%
493	Hypopituitarism	2.8%
494	Hypophysitis	2.8%
495	Brain Stem Neoplasms	2.8%
496	Subacute Sclerosing Panencephalitis	2.8%
497	Cerebral Arterial Diseases	2.8%
498	Vertebrobasilar Insufficiency	2.8%
499	Basilar Artery Stenosis	2.8%
500	Vertebral Artery Stenosis	2.8%
501	Intracranial Hemorrhage, Hypertensive	2.8%
502	Transient Cerebral Ischemia	2.8%
503	Vertebral Artery Dissection	2.8%
504	Lateral Medullary Syndrome	2.8%
505	Prune Belly Syndrome	2.8%
506	Twins, Conjoined	2.8%
507	Waardenburg Syndrome	2.8%
508	Scimitar Syndrome	2.8%
509	Kwashiorkor	2.8%
510	Magnesium Deficiency	2.8%
511	Potassium Deficiency	2.8%
512	Protein Deficiency	2.8%
513	Avitaminosis	2.8%
514	Central Nervous System Bacterial Infections	2.8%
515	Microcephaly	2.7%
516	Macrocephaly	2.7%
517	Ophthalmia Neonatorum	2.7%
518	Denys-Drash Syndrome	2.7%
519	Meningomyelocele	2.6%
520	Spina Bifida	2.6%
521	Lambert-Eaton Myasthenic Syndrome	2.6%
522	Brain Contusion	2.6%
523	Peripheral Nerve Injuries	2.6%
524	Myasthenia Gravis	2.6%
525	Brain Concussion	2.5%
526	Scrapie	2.5%
527	Central Cord Syndrome	2.5%
528	Chorea	2.5%
529	Carotid Stenosis	2.5%
530	Intracranial Aneurysm	2.5%
531	Guillain-Barre Syndrome	2.5%
532	Intracranial Arteriosclerosis	2.5%
533	Cerebral Atherosclerosis	2.5%
534	Subarachnoid Hemorrhage	2.5%
535	Cerebral Arteriosclerosis	2.5%
536	Cerebral Hemorrhage	2.5%
537	Cerebral Thrombosis	2.5%
538	Intracranial Embolism	2.5%
539	Intracranial Thrombosis	2.5%
540	Anophthalmos	2.5%
541	Anus, Imperforate	2.5%
542	Microphthalmos	2.5%
543	Paralysis, Obstetric	2.5%
544	Retinopathy of Prematurity	2.5%
545	Limb Deformities, Congenital	2.5%
546	Craniofacial Abnormalities	2.5%
547	Anorectal Malformations	2.5%
548	POEMS Syndrome	2.4%
549	Bronchopulmonary Dysplasia	2.4%
550	Meningitis, Cryptococcal	2.4%
551	Meningitis, Listeria	2.4%
552	Meningitis, Haemophilus	2.4%
553	Meningitis, Pneumococcal	2.4%
554	Porencephaly	2.4%
555	Cluster Headache	2.4%
556	Migraine with Aura	2.4%
557	Familial Hemiplegic Migraine	2.4%
558	Chronic Paroxysmal Hemicrania	2.4%
559	SUNCT Syndrome	2.4%
560	Paroxysmal Hemicrania	2.4%
561	Acrocephalosyndactylia	2.4%
562	Giant Cell Arteritis	2.4%
563	Temporal Arteritis	2.4%
564	Craniosynostosis	2.4%
565	Syndactyly	2.4%
566	Brachycephaly	2.4%
567	Sleep Disorders, Circadian Rhythm	2.3%
568	Meningocele	2.3%
569	Encephalocele	2.3%
570	Botulism	2.3%
571	Carotid Artery Thrombosis	2.2%
572	Alice in Wonderland Syndrome	2.2%
573	Blepharophimosis	2.2%
574	Laryngostenosis	2.2%
575	Mouth Abnormalities	2.2%
576	Respiratory Distress Syndrome, Newborn	2.2%
577	Neuromyelitis Optica	2.2%
578	Esophageal Atresia	2.2%
579	Intestinal Atresia	2.2%
580	Horseshoe Kidney	2.2%
581	Pectus excavatum	2.2%
582	Noonan Syndrome	2.2%
583	Klippel-Feil Syndrome	2.2%
584	Gastroschisis	2.2%
585	Synostosis	2.2%
586	Acrodermatitis	2.2%
587	Lymphangiectasis, Intestinal	2.2%
588	Gianotti-Crosti Syndrome	2.2%
589	Torticollis	2.1%
590	Obesity, Abdominal	2.1%
591	Choroid Plexus Papilloma	2.1%
592	Hyperprolactinemia	2.1%
593	Olfactory Nerve Injuries	2.1%
594	Subclavian Steal Syndrome	2.1%
595	Pick Disease of the Brain	2.1%
596	Dysautonomia	2.1%
597	Vagus Nerve Disorder	2.1%
598	Glossopharyngeal Neuralgia	2.1%
599	Abducens Nerve Diseases	2.1%
600	Heavy Metal Poisoning, Nervous System	2.1%
601	Neuromuscular Junction Diseases	2.1%
602	Tauopathies	2.1%
603	Trochlear Nerve Diseases	2.1%
604	Peripheral Nervous System Diseases	2.1%
605	Ascorbic Acid Deficiency	2.1%
606	Vitamin A Deficiency	2.1%
607	Vitamin D Deficiency	2.1%
608	Vitamin E Deficiency	2.1%
609	Marasmus	2.1%
610	Cleft Palate	2.1%
611	West Nile Fever	2%
612	Progressive bulbar palsy	2%
613	Bulbar palsy	2%
614	Arthrogryposis	2%
615	Choanal Atresia	2%
616	Tracheobronchomegaly	2%
617	Laryngocele	2%
618	Choledochal Cyst	2%
619	Hermaphroditism	2%
620	Disorders of Sex Development	2%
621	Causalgia	2%
622	Cryptorchidism	2%
623	Hypospadias	2%
624	Horner Syndrome	2%
625	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.9%
626	Facial Nerve Injuries	1.9%
627	Pediatric Obesity	1.9%
628	Jaw Abnormalities	1.9%
629	Acromegaly	1.9%
630	Myopathy	1.9%
631	Optic Neuropathy	1.9%
632	Sinus Thrombosis, Intracranial	1.9%
633	Facial Nerve Diseases	1.9%
634	Craniocerebral Trauma	1.9%
635	Parasomnia	1.9%
636	Dyssomnias	1.9%
637	Vestibulocochlear Nerve Diseases	1.8%
638	Decerebrate State	1.8%
639	Hemiparesis	1.8%
640	Meningism	1.8%
641	Paresis	1.8%
642	Seizures	1.8%
643	Sensation Disorders	1.8%
644	Central Nervous System Neoplasms	1.8%
645	Complex partial seizures	1.8%
646	Monoparesis	1.8%
647	Neurogenic Inflammation	1.8%
648	Gait Disorders, Neurologic	1.8%
649	Neuromuscular Manifestations	1.8%
650	Sweating, Gustatory	1.8%
651	Auriculotemporal Syndrome	1.8%
652	Spinal Cord Ischemia	1.8%
653	Laryngomalacia	1.8%
654	Dermal Sinus	1.8%
655	Spina Bifida Cystica	1.8%
656	Spina Bifida Occulta	1.8%
657	Lissencephaly	1.8%
658	Polymicrogyria	1.8%
659	Pachygyria	1.8%
660	Schizencephaly	1.8%
661	Periventricular Nodular Heterotopia	1.8%
662	Hematoma, Subdural	1.8%
663	Hematoma, Epidural, Cranial	1.8%
664	Tuberculosis, Central Nervous System	1.8%
665	Pectus carinatum	1.8%
666	Multiple Sclerosis	1.8%
667	Bladder Exstrophy	1.8%
668	Epispadias	1.8%
669	Jet Lag Syndrome	1.8%
670	Multicystic Dysplastic Kidney	1.8%
671	Myasthenia Gravis, Autoimmune, Experimental	1.8%
672	Poland Syndrome	1.7%
673	Folic Acid Deficiency	1.7%
674	Pellagra	1.7%
675	Thiamine Deficiency	1.7%
676	Vitamin B 12 Deficiency	1.7%
677	Vitamin B 6 Deficiency	1.7%
678	Pyridoxine Deficiency	1.7%
679	Pupil Disorders	1.7%
680	Neurobehavioral Manifestations	1.7%
681	Paraneoplastic Encephalomyelitis	1.7%
682	Uveomeningoencephalitic Syndrome	1.6%
683	Ophthalmoplegia	1.6%
684	External Ophthalmoplegia	1.6%
685	Sturge-Weber Syndrome	1.6%
686	Vertigo	1.6%
687	Alcohol-Induced Disorders, Nervous System	1.6%
688	Neuroaspergillosis	1.6%
689	Vitamin K Deficiency	1.6%
690	Amelia	1.6%
691	Arachnodactyly	1.6%
692	Ectopia Cordis	1.6%
693	Ectromelia	1.6%
694	Hemimelia	1.6%
695	Phocomelia	1.6%
696	Reflex Sympathetic Dystrophy	1.6%
697	Sirenomelia	1.6%
698	Polydactyly	1.6%
699	Brachydactyly	1.6%
700	Plagiocephaly	1.6%
701	Lower Extremity Deformities, Congenital	1.6%
702	Upper Extremity Deformities, Congenital	1.6%
703	Nocturnal Myoclonus Syndrome	1.6%
704	Single umbilical artery	1.6%
705	Tardive Dyskinesia	1.6%
706	Cavernous Sinus Thrombosis	1.6%
707	Sagittal Sinus Thrombosis	1.6%
708	Beriberi	1.5%
709	Prolactinoma	1.5%
710	Growth Hormone-Secreting Pituitary Adenoma	1.5%
711	Pseudorabies	1.5%
712	Vocal Cord Paralysis	1.5%
713	Voice Disorders	1.5%
714	Voice Disturbance	1.5%
715	Micrognathism	1.5%
716	Pierre Robin Syndrome	1.5%
717	Neurosyphilis	1.4%
718	Aortic coarctation	1.4%
719	Cor Triatriatum	1.4%
720	Coronary Vessel Anomalies	1.4%
721	Dental Enamel Hypoplasia	1.4%
722	Patent ductus arteriosus	1.4%
723	Ebstein Anomaly	1.4%
724	Heart Septal Defects	1.4%
725	Hyaline Membrane Disease	1.4%
726	Hypodontia	1.4%
727	Macrostomia	1.4%
728	Microstomia	1.4%
729	Tetralogy of Fallot	1.4%
730	Transposition of Great Vessels	1.4%
731	Hypoplastic Left Heart Syndrome	1.4%
732	May-Thurner Syndrome	1.4%
733	Craniofacial Dysostosis	1.4%
734	Acrodynia	1.4%
735	Wolff-Parkinson-White Syndrome	1.4%
736	Hematoma, Subdural, Intracranial	1.4%
737	Hematoma, Subdural, Chronic	1.4%
738	Hematoma, Subdural, Acute	1.4%
739	Nelson Syndrome	1.4%
740	Hyperandrogenism	1.4%
741	Retrognathia	1.4%
742	Alcohol Withdrawal Seizures	1.4%
743	Anemia, Pernicious	1.4%
744	Scurvy	1.3%
745	Reflex, Abnormal	1.3%
746	Hyporeflexia	1.3%
747	Hyperreflexia	1.3%
748	Lyme Neuroborreliosis	1.3%
749	Long QT Syndrome	1.3%
750	Platybasia	1.3%
751	Tricuspid Atresia	1.3%
752	Arrhythmogenic Right Ventricular Dysplasia	1.3%
753	Gonadal Dysgenesis	1.3%
754	Bronchomalacia	1.3%
755	Adrenogenital Syndrome	1.3%
756	Tracheomalacia	1.3%
757	Ovotesticular Disorders of Sex Development	1.3%
758	Cerebrospinal Fluid Otorrhea	1.3%
759	Cerebrospinal Fluid Rhinorrhea	1.3%
760	Neuritis, Autoimmune, Experimental	1.3%
761	Gait Ataxia	1.3%
762	Prognathism	1.3%
763	Brachial Plexus Neuritis	1.2%
764	Neuralgic Amyotrophy	1.2%
765	Anterior Spinal Artery Syndrome	1.2%
766	Akathisia	1.2%
767	Restlessness	1.2%
768	Psychomotor Agitation	1.2%
769	Coma, Post-Head Injury	1.2%
770	Neuritis	1.2%
771	Polyneuritis	1.2%
772	Radiculitis	1.2%
773	Polyneuropathy	1.2%
774	Mononeuritis	1.2%
775	Mononeuropathies	1.2%
776	Brachial Plexus Neuropathies	1.2%
777	Radiculopathy	1.2%
778	Mononeuropathy Multiplex	1.2%
779	Nerve Root Compression	1.2%
780	Waterhouse-Friderichsen Syndrome	1.1%
781	Optic Nerve Glioma	1.1%
782	Acoustic Neuroma	1.1%
783	Malaria, Cerebral	1.1%
784	Neurocysticercosis	1.1%
785	Aortopulmonary Septal Defect	1.1%
786	Double Outlet Right Ventricle	1.1%
787	Endocardial Cushion Defects	1.1%
788	Multiple Sclerosis, Chronic Progressive	1.1%
789	Multiple Sclerosis, Relapsing-Remitting	1.1%
790	Myocardial bridging	1.1%
791	Aorticopulmonary Septal Defect	1.1%
792	Gait Apraxia	1%
793	Myositis	1%
794	Optic Atrophy	1%
795	Optic Neuritis	1%
796	Papilledema	1%
797	Strabismus	1%
798	Tolosa-Hunt Syndrome	1%
799	Isaacs syndrome	1%
800	Arsenic Poisoning	1%
801	Myotonic Disorders	1%
802	Diabetic Neuropathies	1%
803	Facial Injuries	1%
804	Facial Neuralgia	1%
805	Diabetic Amyotrophy	1%
806	Diabetic Autonomic Neuropathy	1%
807	Sleep Talking	1%
808	Manganese Poisoning	1%
809	Sleep Disorders, Intrinsic	1%
810	Orthostatic intolerance	1%
811	Anosmia	1%
812	Ataxia	1%
813	Athetosis	1%
814	Catalepsy	1%
815	Dystonia	1%
816	Hemiplegia	1%
817	Locked-In Syndrome	1%
818	Meningeal Neoplasms	1%
819	Muscle Hypertonia	1%
820	Muscle hypotonia	1%
821	Myoclonus	1%
822	Myotonia	1%
823	Neuralgia	1%
824	Paraplegia	1%
825	Pseudobulbar Palsy	1%
826	Quadriplegia	1%
827	Spasm	1%
828	Spastic Paraplegia	1%
829	Status Epilepticus	1%
830	Taste Disorders	1%
831	Tremor	1%
832	Monoplegia	1%
833	Hypokinesia	1%
834	Paraparesis	1%
835	Bradykinesia	1%
836	Waxy flexibility	1%
837	Action Tremor	1%
838	Resting Tremor	1%
839	Dysosmia	1%
840	Quadriparesis	1%
841	Mercury Poisoning, Nervous System	1%
842	Olfaction Disorders	1%
843	Myokymia	1%
844	Lead Poisoning, Nervous System	1%
845	Vestibular Neuronitis	1%
846	Somatosensory Disorders	1%
847	Neuropathic pain	1%
848	Hyperkinesia	1%
849	Intention tremor	1%
850	Tarsal Tunnel Syndrome	1%
851	Cauda Equina Syndrome	1%
852	Mandibulofacial Dysostosis	1%
853	Romano-Ward Syndrome	1%
854	Hand-Arm Vibration Syndrome	0.9%
855	Vision Disorders	0.9%
856	Metamorphopsia	0.9%
857	Visual Impairment	0.9%
858	Fibromyalgia	0.9%
859	Optic Neuropathy, Ischemic	0.9%
860	Anterior Ischemic Optic Neuropathy	0.9%
861	Medial Tibial Stress Syndrome	0.9%
862	Facial Hemiatrophy	0.9%
863	Melkersson-Rosenthal Syndrome	0.9%
864	Anisocoria	0.9%
865	Confusion	0.9%
866	Facial paralysis	0.9%
867	Lethargy	0.9%
868	Memory Disorders	0.9%
869	Muscle Cramp	0.9%
870	Perceptual Disorders	0.9%
871	Psychomotor Disorders	0.9%
872	Tonic Pupil	0.9%
873	Eosinophilia-Myalgia Syndrome	0.9%
874	Anhedonia	0.9%
875	Disorientation	0.9%
876	Facial Paresis	0.9%
877	Memory Loss	0.9%
878	Hemisensory Neglect	0.9%
879	Dysacusis	0.9%
880	Sleep Bruxism	0.9%
881	Muscular Atrophy	0.9%
882	Respiratory Paralysis	0.9%
883	Carpal Tunnel Syndrome	0.9%
884	neurofibroma	0.9%
885	Sciatica	0.9%
886	Truncus Arteriosus, Persistent	0.9%
887	Goldenhar Syndrome	0.9%
888	Consciousness Disorders	0.8%
889	Mental Retardation	0.8%
890	Muscle Weakness	0.8%
891	Depressed Level of Consciousness	0.8%
892	Mental deficiency	0.8%
893	Intellectual Disability	0.8%
894	Bell Palsy	0.8%
895	Catatonia	0.8%
896	Herpes Zoster Oticus	0.8%
897	Aphonia	0.8%
898	Sleep Deprivation	0.8%
899	Dysphonia	0.8%
900	Arteriovenous fistula	0.8%
901	Talipes	0.8%
902	Myalgia	0.7%
903	Congenital clubfoot	0.7%
904	Vertical Talus	0.7%
905	Cubital Tunnel Syndrome	0.7%
906	Sciatic Neuropathy	0.7%
907	Ulnar Neuropathies	0.7%
908	Lesion of Sciatic Nerve	0.7%
909	Ulnar Neuritis	0.7%
910	Radial nerve compression	0.7%
911	Radial Tunnel Syndrome	0.7%
912	Peroneal Neuropathies	0.7%
913	Radial Neuropathy	0.7%
914	Median Neuropathy	0.7%
915	Sciatic Nerve Palsy	0.7%
916	Femoral Neuropathy	0.7%
917	Tibial Neuropathy	0.7%
918	Ulnar Nerve Palsy	0.7%
919	Postural Orthostatic Tachycardia Syndrome	0.7%
920	Radial nerve palsy	0.7%
921	Hoarseness	0.7%
922	Alcohol Withdrawal Delirium	0.7%
923	Thoracic Outlet Syndrome	0.6%
924	Esotropia	0.6%
925	Exotropia	0.6%
926	Hypotension, Orthostatic	0.6%
927	Sleep Apnea Syndromes	0.6%
928	Polymyositis	0.6%
929	Post-Exercise Hypotension	0.6%
930	Disorders of Excessive Somnolence	0.6%
931	Sleep Initiation and Maintenance Disorders	0.6%
932	Night Terrors	0.6%
933	Somnambulism	0.6%
934	Trigeminal Nerve Disorder	0.6%
935	Transient Insomnia	0.6%
936	Sleep Paralysis	0.6%
937	Chronic Insomnia	0.6%
938	REM Sleep Behavior Disorder	0.6%
939	Hypersomnia	0.6%
940	Dysgeusia	0.6%
941	Formication	0.6%
942	Hyperalgesia	0.6%
943	Hyperesthesia	0.6%
944	Hypesthesia	0.6%
945	Language Disorders	0.6%
946	Numbness	0.6%
947	Paresthesia	0.6%
948	Paraparesis, Spastic	0.6%
949	Trismus	0.6%
950	Epilepsia Partialis Continua	0.6%
951	Hypogeusia	0.6%
952	Meningeal Carcinomatosis	0.6%
953	Brown-Sequard Syndrome	0.6%
954	Lockjaw	0.6%
955	Allodynia	0.6%
956	Lead Poisoning, Nervous System, Childhood	0.6%
957	Lead Poisoning, Nervous System, Adult	0.6%
958	Ageusia	0.6%
959	Alexia	0.6%
960	Dyslexia	0.6%
961	Eye Injuries	0.6%
962	Orbital Myositis	0.5%
963	Diplopia	0.5%
964	Muscle Rigidity	0.5%
965	Muscle Spasticity	0.5%
966	Scotoma	0.5%
967	Photophobia	0.5%
968	Cogwheel Rigidity	0.5%
969	Hemifacial Spasm	0.5%
970	Amaurosis	0.5%
971	Blindness	0.5%
972	Nuchal Rigidity	0.5%
973	Pyomyositis	0.5%
974	Agnosia	0.5%
975	Apraxias	0.5%
976	Hallucinations	0.5%
977	Hemianopsia	0.5%
978	Hyperacusis	0.5%
979	Tinnitus	0.5%
980	Visual Agnosia	0.5%
981	Anosognosia	0.5%
982	Wernicke-Korsakoff Syndrome	0.5%
983	Phonophobia	0.5%
984	Hearing Loss	0.5%
985	Sarcopenia	0.5%
986	Neurofibrosarcoma	0.5%
987	Amnesia	0.5%
988	Delirium	0.5%
989	Dissociative Amnesia	0.5%
990	Color blindness	0.5%
991	Global Amnesia	0.5%
992	Meningioma	0.5%
993	Polyradiculopathy	0.5%
994	Phantom pain	0.4%
995	Phantom Limb Pain	0.4%
996	Sleep Apnea, Obstructive	0.4%
997	Sleep Apnea, Central	0.4%
998	Narcolepsy	0.4%
999	Trigeminal Neuralgia	0.4%
1000	Kleine-Levin Syndrome	0.4%
1001	Agraphia	0.4%
1002	Anomia	0.4%
1003	Cluttering	0.4%
1004	Language Development Disorders	0.4%
1005	Speech Disorders	0.4%
1006	Syncope	0.4%
1007	Stupor	0.4%
1008	Dysgraphia	0.4%
1009	Presyncope	0.4%
1010	Dyslalia	0.4%
1011	Eye Burns	0.4%
1012	Amaurosis Fugax	0.4%
1013	Blindness, Cortical	0.4%
1014	Dyscalculia	0.4%
1015	Deafness	0.4%
1016	Hearing Loss, Sudden	0.4%
1017	Gerstmann Syndrome	0.4%
1018	Hearing Loss, Bilateral	0.4%
1019	Hearing Loss, High-Frequency	0.4%
1020	Hearing Loss, Mixed Conductive-Sensorineural	0.4%
1021	Prosopagnosia	0.4%
1022	Apraxia, Ideomotor	0.4%
1023	Charles Bonnet Syndrome	0.4%
1024	Hearing Loss, Unilateral	0.4%
1025	Complete Hearing Loss	0.4%
1026	Alien Hand Syndrome	0.4%
1027	Deaf Mutism	0.4%
1028	Dermatomyositis	0.3%
1029	Corneal Scar	0.3%
1030	Retrograde amnesia	0.3%
1031	Amnesia, Anterograde	0.3%
1032	Cataplexy	0.3%
1033	Aphasia	0.3%
1034	Articulation Disorders	0.3%
1035	Echolalia	0.3%
1036	Stuttering	0.3%
1037	Dysphasia	0.3%
1038	Mutism	0.3%
1039	Selective Mutism	0.3%
1040	Dysarthria	0.2%
1041	Corneal Perforation	0.2%
1042	Alexia, Pure	0.2%

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