MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Sirenomelia

(UMLS:C0037205)

UMLS ID:: C0037205
MeSH ID:: D004480

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.660.585.350

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.585.350

Synonym(s)

Sirenomelia

SIRENOMELIA

Siren

Sireniform fetus

Sirenoform monster

Sirenomelia sequence

Sirenomelus

Sirenomelus sequence

Symelia

10.

Symmelia

11.

Symmelus

12.

Sympodia

13.

Sympus

14.

Sympus apus

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Clarithromycin	FAERS: 5		US FAERS
2	Methylergonovine	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Arachnodactyly	47.5%
2	Polydactyly	47.5%
3	Brachydactyly	47.5%
4	Lower Extremity Deformities, Congenital	47.5%
5	Upper Extremity Deformities, Congenital	47.5%
6	Syndactyly	40.3%
7	Craniofacial Abnormalities	32.8%
8	Poland Syndrome	30%
9	Arthrogryposis	29.1%
10	Pectus excavatum	28.9%
11	Acrocephalosyndactylia	28.4%
12	Klippel-Feil Syndrome	28%
13	Synostosis	28%
14	Gastroschisis	26%
15	Craniosynostosis	25.4%
16	Brachycephaly	25.4%
17	Talipes	24%
18	Pectus carinatum	23.7%
19	Plagiocephaly	21.3%
20	Congenital clubfoot	20.7%
21	Vertical Talus	20.7%
22	Maxillofacial Abnormalities	19.4%
23	Holoprosencephaly	19.4%
24	Craniofacial Dysostosis	19%
25	Platybasia	18.7%
26	Rubinstein-Taybi Syndrome	18.2%
27	Abnormalities, Drug-Induced	16.9%
28	Situs Inversus	16.9%
29	Microcephaly	16.5%
30	Macrocephaly	16.5%
31	Antley-Bixler Syndrome Phenotype	14.2%
32	Beckwith-Wiedemann Syndrome	13.9%
33	Wolf-Hirschhorn Syndrome	13.9%
34	Noonan Syndrome	13.3%
35	Eye Abnormalities	13.3%
36	Cardiovascular Abnormalities	13.3%
37	Laryngomalacia	13.2%
38	Jaw Abnormalities	13.1%
39	Porencephaly	12.9%
40	Skin Abnormalities	12.8%
41	Lymphatic Abnormalities	12.8%
42	Congenital Microtia	12.8%
43	Congenital diaphragmatic hernia	12.5%
44	Mandibulofacial Dysostosis	11.9%
45	Goldenhar Syndrome	11.9%
46	Bone Diseases	11.8%
47	Fasciitis	11.8%
48	Foot Deformities	11.8%
49	Arthropathy	11.8%
50	Smith-Magenis syndrome	11.7%
51	Cri-du-Chat Syndrome	11.5%
52	Down Syndrome	11.5%
53	Trisomy 21	11.5%
54	Aicardi's syndrome	11.3%
55	Nail-Patella Syndrome	11.3%
56	Urogenital Abnormalities	10.6%
57	Genetic Diseases, Inborn	10.6%
58	Contracture	10.3%
59	Osteoarthropathy, Secondary Hypertrophic	10.3%
60	Fasciitis, Plantar	10.3%
61	Micrognathism	10%
62	Pierre Robin Syndrome	10%
63	Ectodermal Dysplasia	10%
64	Aplasia Cutis Congenita	10%
65	Prune Belly Syndrome	9.9%
66	Twins, Conjoined	9.9%
67	Waardenburg Syndrome	9.9%
68	Anencephaly	9.9%
69	Prader-Willi Syndrome	9.9%
70	Bronchomalacia	9.8%
71	Tracheomalacia	9.8%
72	CHARGE Syndrome	9.4%
73	Prognathism	9.4%
74	Jaw Diseases	9.2%
75	Cleft Palate	9.1%
76	Marfan Syndrome	9%
77	Retrognathia	8.9%
78	Cartilage Diseases	8.8%
79	Foot Diseases	8.8%
80	Myopathy	8.8%
81	Rheumatism	8.8%
82	Chondromalacia	8.8%
83	Dural Arteriovenous Fistula	8.3%
84	Dextrocardia	8.2%
85	Fibromyalgia	8.2%
86	Osteochondritis	8.2%
87	Polymyalgia Rheumatica	8.2%
88	Metatarsalgia	8.1%
89	Fetal Diseases	8%
90	Xeroderma	7.8%
91	Mobius Syndrome	7.8%
92	Gout	7.6%
93	Anophthalmos	7.6%
94	Anus, Imperforate	7.6%
95	Hydranencephaly	7.6%
96	Microphthalmos	7.6%
97	Multiple Epiphyseal Dysplasia	7.6%
98	Neural Tube Defects	7.6%
99	Osteochondrodysplasias	7.6%
100	Tethered Cord Syndrome	7.6%
101	Iniencephaly	7.6%
102	Craniorachischisis	7.6%
103	Exencephaly	7.6%
104	Septo-Optic Dysplasia	7.6%
105	Cortical Dysplasia	7.6%
106	Malformations of Cortical Development	7.6%
107	Anorectal Malformations	7.6%
108	Bloom Syndrome	7.4%
109	Cockayne Syndrome	7.4%
110	Kartagener Syndrome	7.4%
111	Abnormalities, Radiation-Induced	7.1%
112	Osteoarthritis, Spine	6.8%
113	Arthritis	6.7%
114	Bone Diseases, Developmental	6.7%
115	Bursitis	6.7%
116	Hyperostosis	6.7%
117	Joint Instability	6.7%
118	Myofascial Pain Syndromes	6.7%
119	Osteitis	6.7%
120	Osteitis Deformans	6.7%
121	Osteochondrosis	6.7%
122	Rhabdomyolysis	6.7%
123	Spinal Diseases	6.7%
124	Synovitis	6.7%
125	Joint laxity	6.7%
126	Polyarthritis	6.7%
127	Frozen shoulder	6.7%
128	Patellofemoral Pain Syndrome	6.7%
129	Rheumatic Fever	6.7%
130	Ischemic contracture	6.6%
131	Hip Contracture	6.6%
132	Periarthritis	6.6%
133	Polycystic Kidney Diseases	6.5%
134	Williams Syndrome	6.5%
135	Scimitar Syndrome	6.4%
136	Temporomandibular Joint Disorders	6.3%
137	Dwarfism	6.3%
138	Blepharophimosis	6.1%
139	Laryngostenosis	6.1%
140	Mouth Abnormalities	6.1%
141	Esophageal Atresia	6%
142	Intestinal Atresia	6%
143	Horseshoe Kidney	6%
144	Muscular Dystrophy	6%
145	Acrodermatitis	6%
146	Lymphangiectasis, Intestinal	6%
147	Gianotti-Crosti Syndrome	6%
148	Retinal Dysplasia	5.9%
149	Aniridia	5.8%
150	Cystic Fibrosis	5.8%
151	Osteoarthritis, Knee	5.7%
152	Epidermolysis Bullosa	5.7%
153	Ankylosing spondylitis	5.7%
154	Basal Cell Nevus Syndrome	5.7%
155	Rheumatoid Arthritis	5.6%
156	Juvenile arthritis	5.6%
157	Alstrom Syndrome	5.6%
158	Abdominal Cramps	5.6%
159	Amniotic Band Syndrome	5.6%
160	Asphyxia Neonatorum	5.6%
161	Infant, Premature, Diseases	5.6%
162	Infantile Colic	5.6%
163	Temporomandibular Joint Dysfunction Syndrome	5.6%
164	Fragile X Syndrome	5.5%
165	Osteogenesis Imperfecta	5.3%
166	Arthritis, Gouty	5.3%
167	Bone Diseases, Endocrine	5.3%
168	Gigantism	5.3%
169	Spinal Neoplasms	5.3%
170	Spondylitis	5.3%
171	Primary Ciliary Dyskinesia	5.3%
172	Smith-Lemli-Opitz Syndrome	5.3%
173	Choanal Atresia	5.1%
174	Tracheobronchomegaly	5.1%
175	Laryngocele	5.1%
176	Bone Diseases, Infectious	5.1%
177	Bone neoplasms	5.1%
178	Compartment syndromes	5.1%
179	Maxillary Diseases	5.1%
180	Osteopenia	5.1%
181	Tendinitis	5.1%
182	Tendinopathy	5.1%
183	Choledochal Cyst	5.1%
184	Hermaphroditism	5.1%
185	Disorders of Sex Development	5.1%
186	Ichthyosis, X-Linked	5.1%
187	Bone Resorption	5%
188	Hemarthrosis	5%
189	Myositis	5%
190	Tietze's Syndrome	5%
191	Isaacs syndrome	5%
192	Aseptic Necrosis of Bone	5%
193	Myotonic Disorders	5%
194	Cryptorchidism	5%
195	Hypospadias	5%
196	Central Nervous System Cysts	5%
197	Dandy-Walker Syndrome	5%
198	Ectopia Cordis	4.9%
199	Meningomyelocele	4.9%
200	Spina Bifida	4.9%
201	POEMS Syndrome	4.9%
202	Single umbilical artery	4.9%
203	Muscular Dystrophy, Duchenne	4.9%
204	Meconium Aspiration Syndrome	4.9%
205	Congenital Hypothyroidism	4.8%
206	Myotonic Dystrophy	4.7%
207	Arthritis, Psoriatic	4.7%
208	Classical Lissencephalies and Subcortical Band Heterotopias	4.7%
209	Rheumatoid Nodule	4.6%
210	Turner Syndrome	4.5%
211	Spondylarthropathies	4.5%
212	Pseudoxanthoma Elasticum	4.4%
213	Neoplastic Syndromes, Hereditary	4.4%
214	Familial Periodic Paralysis	4.4%
215	Ainhum	4.4%
216	Bunion	4.4%
217	Dysostoses	4.4%
218	Fibrodysplasia Ossificans Progressiva	4.4%
219	Myoglobinuria	4.4%
220	Myositis Ossificans	4.4%
221	Spinal Stenosis	4.4%
222	Spondylosis	4.4%
223	Tenosynovitis	4.4%
224	Intervertebral Disc Degeneration	4.4%
225	Sacroiliitis	4.4%
226	Polycystic Kidney, Autosomal Dominant	4.3%
227	Bladder Exstrophy	4.3%
228	Epispadias	4.3%
229	Multicystic Dysplastic Kidney	4.3%
230	Anemia, Neonatal	4.2%
231	Pelger-Huet Anomaly	4.2%
232	Persistent Fetal Circulation Syndrome	4.2%
233	Werner Syndrome	4.2%
234	Myasthenic Syndromes, Congenital	4.2%
235	Arthritis, Reactive	4.2%
236	Umbilical hernia	4.1%
237	Medial Tibial Stress Syndrome	4.1%
238	Mitochondrial Myopathies	4%
239	Xeroderma Pigmentosum	4%
240	Muscle Cramp	4%
241	Eosinophilia-Myalgia Syndrome	4%
242	Sjogren-Larsson Syndrome	4%
243	Muscle Rigidity	4%
244	Muscle Spasticity	4%
245	Cogwheel Rigidity	4%
246	Nuchal Rigidity	4%
247	Aortic coarctation	3.9%
248	Cor Triatriatum	3.9%
249	Coronary Vessel Anomalies	3.9%
250	Dental Enamel Hypoplasia	3.9%
251	Patent ductus arteriosus	3.9%
252	Ebstein Anomaly	3.9%
253	Heart Septal Defects	3.9%
254	Hypodontia	3.9%
255	Macrostomia	3.9%
256	Meningocele	3.9%
257	Microstomia	3.9%
258	Tetralogy of Fallot	3.9%
259	Transposition of Great Vessels	3.9%
260	Hypoplastic Left Heart Syndrome	3.9%
261	May-Thurner Syndrome	3.9%
262	Encephalocele	3.9%
263	Welander Distal Myopathy	3.9%
264	Discitis	3.9%
265	Wolff-Parkinson-White Syndrome	3.9%
266	Kallmann Syndrome	3.9%
267	Myotonia Congenita	3.8%
268	Felty Syndrome	3.8%
269	Klinefelter Syndrome	3.8%
270	Charcot-Marie-Tooth Disease	3.7%
271	Dermal Sinus	3.6%
272	Spina Bifida Cystica	3.6%
273	Spina Bifida Occulta	3.6%
274	Lissencephaly	3.6%
275	Polymicrogyria	3.6%
276	Pachygyria	3.6%
277	Schizencephaly	3.6%
278	Periventricular Nodular Heterotopia	3.6%
279	Zellweger Syndrome	3.5%
280	Chronic Fatigue Syndrome	3.5%
281	Neonatal Abstinence Syndrome	3.4%
282	Hyperkeratosis, Epidermolytic	3.4%
283	Giant Cell Epulis	3.4%
284	Muscle Weakness	3.4%
285	Arthritis, Infectious	3.4%
286	Fetal Growth Retardation	3.4%
287	Musculoskeletal Pain	3.3%
288	Fetal Hypoxia	3.3%
289	Congenital nystagmus	3.3%
290	Fetal Alcohol Spectrum Disorders	3.3%
291	Anterior Compartment Syndrome	3.3%
292	Osteomyelitis	3.3%
293	Osteoporosis	3.3%
294	Periostitis	3.3%
295	Enthesopathy	3.3%
296	Bone Demineralization, Pathologic	3.3%
297	Post-Traumatic Osteoporosis	3.3%
298	Arthritis, Experimental	3.3%
299	Abdominal Compartment Syndrome	3.3%
300	Toxoplasmosis, Congenital	3.3%
301	Arthralgia	3.3%
302	Long QT Syndrome	3.3%
303	Familial Mediterranean Fever	3.3%
304	Polyarthralgia	3.3%
305	Tricuspid Atresia	3.3%
306	Arrhythmogenic Right Ventricular Dysplasia	3.3%
307	Syphilis, Congenital	3.3%
308	Anemia, Sickle Cell	3.3%
309	Thalassemia	3.3%
310	Alveolar Bone Loss	3.3%
311	Femur Head Necrosis	3.3%
312	Gonadal Dysgenesis	3.3%
313	Polymyositis	3.3%
314	Adrenogenital Syndrome	3.3%
315	Ovotesticular Disorders of Sex Development	3.3%
316	Osteolysis	3.3%
317	Rheumatoid Vasculitis	3.3%
318	Chondrodysplasia Punctata	3.3%
319	Enchondromatosis	3.3%
320	Lordosis	3.3%
321	Osteosclerosis	3.3%
322	Spondylolysis	3.3%
323	kyphosis	3.3%
324	Kashin-Beck Disease	3.3%
325	Tuberculosis, Spinal	3.2%
326	Tuberous Sclerosis	3.2%
327	Refsum Disease	3%
328	Hypokalemic periodic paralysis	3%
329	Albinism	2.9%
330	Aortopulmonary Septal Defect	2.9%
331	Double Outlet Right Ventricle	2.9%
332	Endocardial Cushion Defects	2.9%
333	Myocardial bridging	2.9%
334	Aorticopulmonary Septal Defect	2.9%
335	Hyperandrogenism	2.9%
336	Sicca Syndrome	2.9%
337	Sjogren's Syndrome	2.9%
338	Eosinophilic Granuloma	2.8%
339	Autoimmune Lymphoproliferative Syndrome	2.8%
340	Myalgia	2.8%
341	Pseudohypoparathyroidism	2.8%
342	Congenital Hyperinsulinism	2.8%
343	Chorioamnionitis	2.8%
344	Angioedemas, Hereditary	2.7%
345	Hip Dislocation	2.7%
346	Shoulder Dislocation	2.7%
347	Hip Dysplasia	2.7%
348	Melorheostosis	2.7%
349	Osteopetrosis	2.7%
350	Spondylolisthesis	2.7%
351	Orbital Myositis	2.7%
352	Dupuytren Contracture	2.7%
353	Palatal Neoplasms	2.7%
354	Pyomyositis	2.6%
355	Acromegaly	2.6%
356	Joint Tuberculosis	2.6%
357	Tuberculosis, Osteoarticular	2.6%
358	Bone Tuberculosis	2.6%
359	Rett Syndrome	2.6%
360	Paralysis, Obstetric	2.5%
361	Retinopathy of Prematurity	2.5%
362	Amino Acid Metabolism, Inborn Errors	2.5%
363	Carbohydrate Metabolism, Inborn Errors	2.5%
364	Metal Metabolism, Inborn Errors	2.5%
365	Progeria	2.5%
366	Lysosomal Storage Diseases	2.5%
367	Cytochrome-c Oxidase Deficiency	2.5%
368	Peroxisomal Disorders	2.5%
369	Wiskott-Aldrich Syndrome	2.5%
370	Bronchopulmonary Dysplasia	2.5%
371	Osteoporosis, Postmenopausal	2.4%
372	Romano-Ward Syndrome	2.4%
373	Truncus Arteriosus, Persistent	2.4%
374	Mucopolysaccharidosis II	2.2%
375	Rickets	2.2%
376	Menkes Kinky Hair Syndrome	2.2%
377	Shoulder Pain	2.2%
378	Sickle Cell Trait	2.2%
379	Neuronal Ceroid-Lipofuscinoses	2.1%
380	Ophthalmia Neonatorum	2%
381	Respiratory Distress Syndrome, Newborn	2%
382	Cutis Laxa	2%
383	Retinitis Pigmentosa	2%
384	Pigmentary retinopathy	2%
385	Porokeratosis	2%
386	Keratoderma, Palmoplantar	2%
387	Chronic granulomatous disease	2%
388	Mastoiditis	1.9%
389	Petrositis	1.9%
390	Mitochondrial Encephalomyopathies	1.9%
391	Ataxia Telangiectasia	1.9%
392	Arteriovenous fistula	1.8%
393	Amyloid Neuropathies, Familial	1.8%
394	Hepatolenticular Degeneration	1.8%
395	Adrenoleukodystrophy	1.7%
396	Duane Retraction Syndrome	1.7%
397	Porphyrias, Hepatic	1.7%
398	Dermatomyositis	1.7%
399	Acute Chest Syndrome	1.7%
400	Peutz-Jeghers Syndrome	1.7%
401	Hydrops Fetalis	1.6%
402	Thrombasthenia	1.6%
403	Antithrombin III Deficiency	1.6%
404	Protein C Deficiency	1.6%
405	Brain Diseases, Metabolic, Inborn	1.6%
406	Afibrinogenemia	1.6%
407	Dystonia Musculorum Deformans	1.6%
408	Factor VII Deficiency	1.6%
409	Factor X Deficiency	1.6%
410	Factor XII Deficiency	1.6%
411	Hemophilia A	1.6%
412	Leukomalacia, Periventricular	1.6%
413	Activated Protein C Resistance	1.6%
414	Factor II deficiency	1.6%
415	Factor VIII Deficiency	1.6%
416	Factor V deficiency	1.6%
417	Factor XI Deficiency	1.6%
418	Hypoprothrombinemias	1.6%
419	Fanconi Anemia	1.6%
420	Nesidioblastosis	1.6%
421	Alkaptonuria	1.6%
422	Glycogen Storage Disease	1.6%
423	Hypophosphatasia	1.6%
424	Propionic acidemia	1.6%
425	Dihydropyrimidine Dehydrogenase Deficiency	1.6%
426	Cystinosis	1.6%
427	Lafora Disease	1.6%
428	Unverricht-Lundborg Syndrome	1.6%
429	Anemia, Diamond-Blackfan	1.6%
430	Galactosemias	1.6%
431	Urea Cycle Disorders, Inborn	1.6%
432	Tyrosinemias	1.6%
433	Osteomalacia	1.6%
434	Fabry Disease	1.5%
435	Denys-Drash Syndrome	1.5%
436	Multiple Endocrine Neoplasia	1.5%
437	MELAS Syndrome	1.5%
438	Canavan Disease	1.5%
439	Alexander Disease	1.5%
440	Optic Atrophy, Hereditary, Leber	1.4%
441	Glycogen storage disease type II	1.4%
442	Hyperphosphaturia	1.4%
443	Dermatitis, Atopic	1.4%
444	Mucopolysaccharidosis III	1.4%
445	Hyaline Membrane Disease	1.3%
446	Hypolipoproteinemias	1.3%
447	Papillon-Lefevre Disease	1.3%
448	Hyperlipidemia, Familial Combined	1.3%
449	Hyperlipoproteinemia Type III	1.3%
450	Homocystinuria	1.3%
451	Leigh Disease	1.3%
452	Familial Hypophosphatemic Rickets	1.3%
453	Kernicterus	1.3%
454	Behcet Syndrome	1.2%
455	Glycogen Storage Disease Type I	1.2%
456	Glycogen Storage Disease Type V	1.2%
457	Radicular Cyst	1.2%
458	Nose Neoplasms	1.1%
459	Huntington Disease	1.1%
460	Lactose Intolerance	1.1%
461	Variegate Porphyria	1.1%
462	Acute intermittent porphyria	1.1%
463	Porphyria Cutanea Tarda	1.1%
464	Hyperhomocysteinemia	1.1%
465	Gaucher Disease	1.1%
466	Renal Osteodystrophy	1.1%
467	Renal rickets	1.1%
468	Renal Aminoacidurias	1.1%
469	Fanconi Syndrome	1.1%
470	Pseudohypoaldosteronism	1.1%
471	Liddle Syndrome	1.1%
472	Hyperlipoproteinemia Type IV	1.1%
473	Hyperlipoproteinemia Type V	1.1%
474	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.1%
475	Nephroblastoma	1%
476	Hypoalphalipoproteinemias	1%
477	Multiple Endocrine Neoplasia Type 1	0.9%
478	Friedreich Ataxia	0.9%
479	Renal tubular acidosis	0.9%
480	Tay-Sachs Disease	0.9%
481	Niemann-Pick Disease, Type C	0.9%
482	Adenomatous Polyposis Coli	0.9%
483	Kearns-Sayre syndrome	0.8%
484	Cystinuria	0.8%
485	Glycosuria, Renal	0.7%

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