MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Holoprosencephaly

(UMLS:C0079541)

Definition:: Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe INTELLECTUAL DISABILITY; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of INTELLECTUAL DISABILITY. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild INTELLECTUAL DISABILITY to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES.
UMLS ID:: C0079541
MeSH ID:: D016142

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.660.207.410

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.034.875

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.410|C16.131.260.380|C16.131.621.207.410|C16.131.666.034.875|C16.320.180.380

Synonym(s)

Holoprosencephaly

Familial alobar holoprosencephaly

HPE - Holoprosencephaly

Holoprosencephaly Sequence

Holoprosencephaly sequence

Single brain ventricle

holoprosencephaly

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Metformin	FAERS: 10		US FAERS
2	Lamotrigine	FAERS: 7		OFFSIDES US FAERS
3	Methotrexate	FAERS: 7	16470853	CTD US FAERS
4	Fluoxetine	FAERS: 4		US FAERS
5	Cabergoline	FAERS: 3		OFFSIDES US FAERS
6	Metformin	FAERS: 3		US FAERS
7	Sertraline	FAERS: 3		US FAERS
8	Zidovudine	FAERS: 3		US FAERS
9	Aspirin	FAERS: 2		US FAERS
10	Hydroxyurea	FAERS: 2		US FAERS
11	Lovastatin	FAERS: 2		US FAERS
12	Paroxetine	FAERS: 2		US FAERS
13	Ramipril	FAERS: 2		US FAERS
14	Citalopram	FAERS: 1		US FAERS
15	Clomiphene	FAERS: 1		US FAERS
16	Mometasone Furoate	FAERS: 1		US FAERS
17	Mycophenolic Acid	FAERS: 1		US FAERS
18	Norgestrel	FAERS: 1		US FAERS
19	Omeprazole	FAERS: 1		US FAERS
20	Quetiapine Fumarate	FAERS: 1		US FAERS
21	Tacrolimus	FAERS: 1		US FAERS
22	Valproic Acid	FAERS: 1		US FAERS
23	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
24	Amphetamine		8207770	CTD
25	Dapsone			OFFSIDES
26	HhAntag691		27585885	CTD
27	Misoprostol		20933185	CTD
28	Phenytoin		8351644	CTD
29	Tenofovir			OFFSIDES
30	cyclopamine		22265815 23264560	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Rubinstein-Taybi Syndrome	60.5%
2	Beckwith-Wiedemann Syndrome	55%
3	Wolf-Hirschhorn Syndrome	55%
4	Aicardi's syndrome	53.7%
5	Smith-Magenis syndrome	52.1%
6	Cri-du-Chat Syndrome	50.8%
7	Down Syndrome	50.8%
8	Trisomy 21	50.8%
9	Prader-Willi Syndrome	46.4%
10	Maxillofacial Abnormalities	39.6%
11	Craniosynostosis	38.4%
12	Brachycephaly	38.4%
13	Microcephaly	37.7%
14	Macrocephaly	37.7%
15	Ectodermal Dysplasia	37%
16	Aplasia Cutis Congenita	37%
17	Acrocephalosyndactylia	37%
18	Kartagener Syndrome	35.2%
19	Alstrom Syndrome	34.3%
20	CHARGE Syndrome	34%
21	Marfan Syndrome	33.2%
22	Dural Arteriovenous Fistula	32.9%
23	Nail-Patella Syndrome	32.9%
24	Anencephaly	32.7%
25	Holoprosencephaly	32.1%
26	Williams Syndrome	32%
27	Porencephaly	31.8%
28	Fragile X Syndrome	31.7%
29	Plagiocephaly	31.1%
30	Cockayne Syndrome	30.8%
31	Noonan Syndrome	30.1%
32	Abnormalities, Drug-Induced	30%
33	Situs Inversus	30%
34	Syndactyly	29.7%
35	Craniofacial Dysostosis	28.9%
36	Mobius Syndrome	28.5%
37	Hydranencephaly	28.1%
38	Neural Tube Defects	28.1%
39	Tethered Cord Syndrome	28.1%
40	Iniencephaly	28.1%
41	Craniorachischisis	28.1%
42	Limb Deformities, Congenital	28.1%
43	Exencephaly	28.1%
44	Septo-Optic Dysplasia	28.1%
45	Cortical Dysplasia	28.1%
46	Malformations of Cortical Development	28.1%
47	Platybasia	27.9%
48	Eye Abnormalities	27.3%
49	Cardiovascular Abnormalities	27.3%
50	Arthrogryposis	27%
51	Skin Abnormalities	26.9%
52	Lymphatic Abnormalities	26.9%
53	Congenital Microtia	26.9%
54	Jaw Abnormalities	26.7%
55	Pectus excavatum	26.7%
56	Congenital diaphragmatic hernia	26.6%
57	Polycystic Kidney Diseases	26.3%
58	Klippel-Feil Syndrome	26.2%
59	Synostosis	26.2%
60	Classical Lissencephalies and Subcortical Band Heterotopias	26.1%
61	Prune Belly Syndrome	25.6%
62	Waardenburg Syndrome	25.6%
63	Gastroschisis	25.2%
64	Smith-Lemli-Opitz Syndrome	25.2%
65	Ichthyosis, X-Linked	25.1%
66	Dandy-Walker Syndrome	24.7%
67	Urogenital Abnormalities	24.7%
68	Cleft Palate	24.4%
69	Central Nervous System Cysts	24.2%
70	Turner Syndrome	24%
71	Pectus carinatum	24%
72	Dextrocardia	23.7%
73	Poland Syndrome	23.1%
74	Bloom Syndrome	22.8%
75	Xeroderma	22.4%
76	Primary Ciliary Dyskinesia	22.1%
77	Tuberous Sclerosis	21.7%
78	Micrognathism	21.7%
79	Pierre Robin Syndrome	21.7%
80	Refsum Disease	21.3%
81	Charcot-Marie-Tooth Disease	21.1%
82	Cystic Fibrosis	21%
83	Klinefelter Syndrome	20.6%
84	Scimitar Syndrome	20.4%
85	Antley-Bixler Syndrome Phenotype	20.3%
86	Mandibulofacial Dysostosis	20.2%
87	Retinal Dysplasia	20.2%
88	Retrognathia	20.2%
89	Aniridia	20.1%
90	Epidermolysis Bullosa	19.9%
91	Abnormalities, Radiation-Induced	19.9%
92	Zellweger Syndrome	19.8%
93	Prognathism	19.7%
94	Basal Cell Nevus Syndrome	19.5%
95	POEMS Syndrome	19.5%
96	Amelia	19.4%
97	Arachnodactyly	19.4%
98	Ectromelia	19.4%
99	Hemimelia	19.4%
100	Meningomyelocele	19.4%
101	Phocomelia	19.4%
102	Sirenomelia	19.4%
103	Spina Bifida	19.4%
104	Polydactyly	19.4%
105	Brachydactyly	19.4%
106	Lower Extremity Deformities, Congenital	19.4%
107	Upper Extremity Deformities, Congenital	19.4%
108	Twins, Conjoined	19%
109	Polycystic Kidney, Autosomal Dominant	19%
110	Sjogren-Larsson Syndrome	18.9%
111	Goldenhar Syndrome	18.9%
112	Fetal Diseases	18.2%
113	Laryngomalacia	18%
114	Meningocele	17.5%
115	Encephalocele	17.5%
116	Muscular Dystrophy, Duchenne	17.2%
117	Pseudoxanthoma Elasticum	17.1%
118	Anophthalmos	17%
119	Anus, Imperforate	17%
120	Microphthalmos	17%
121	Anorectal Malformations	17%
122	Kallmann Syndrome	16.8%
123	Albinism	16.8%
124	Multiple Epiphyseal Dysplasia	16.3%
125	Osteochondrodysplasias	16.3%
126	Myasthenic Syndromes, Congenital	16.3%
127	Genetic Diseases, Inborn	16.1%
128	Myotonic Dystrophy	16.1%
129	Xeroderma Pigmentosum	16%
130	Meconium Aspiration Syndrome	15.7%
131	Muscular Dystrophy	15.6%
132	Anemia, Sickle Cell	15.6%
133	Thalassemia	15.6%
134	Menkes Kinky Hair Syndrome	15.5%
135	Mucopolysaccharidosis II	15.5%
136	Blepharophimosis	15.4%
137	Laryngostenosis	15.4%
138	Mouth Abnormalities	15.4%
139	Esophageal Atresia	15.3%
140	Intestinal Atresia	15.3%
141	Horseshoe Kidney	15.3%
142	Acrodermatitis	15.2%
143	Lymphangiectasis, Intestinal	15.2%
144	Gianotti-Crosti Syndrome	15.2%
145	Neoplastic Syndromes, Hereditary	15.2%
146	Dermal Sinus	15.1%
147	Spina Bifida Cystica	15.1%
148	Spina Bifida Occulta	15.1%
149	Lissencephaly	15.1%
150	Polymicrogyria	15.1%
151	Pachygyria	15.1%
152	Schizencephaly	15.1%
153	Periventricular Nodular Heterotopia	15.1%
154	Dwarfism	15%
155	Adrenoleukodystrophy	14.8%
156	Pelger-Huet Anomaly	14.8%
157	Werner Syndrome	14.8%
158	Hyperkeratosis, Epidermolytic	14.6%
159	Osteogenesis Imperfecta	14.3%
160	Hepatolenticular Degeneration	14.2%
161	Choanal Atresia	14.1%
162	Tracheobronchomegaly	14.1%
163	Laryngocele	14.1%
164	Choledochal Cyst	14%
165	Hermaphroditism	14%
166	Disorders of Sex Development	14%
167	Cryptorchidism	13.9%
168	Hypospadias	13.9%
169	Craniofacial Abnormalities	13.7%
170	Bronchomalacia	13.5%
171	Tracheomalacia	13.5%
172	Rett Syndrome	13.3%
173	Wiskott-Aldrich Syndrome	13.2%
174	Talipes	13%
175	Bladder Exstrophy	12.7%
176	Epispadias	12.7%
177	Multicystic Dysplastic Kidney	12.7%
178	Neuronal Ceroid-Lipofuscinoses	12.4%
179	Autoimmune Lymphoproliferative Syndrome	12.2%
180	Fabry Disease	12.2%
181	Amyloid Neuropathies, Familial	12.1%
182	Ectopia Cordis	12.1%
183	Single umbilical artery	12.1%
184	Ataxia Telangiectasia	12%
185	Angioedemas, Hereditary	12%
186	Canavan Disease	11.8%
187	Alexander Disease	11.8%
188	Abdominal Cramps	11.7%
189	Amniotic Band Syndrome	11.7%
190	Asphyxia Neonatorum	11.7%
191	Infant, Premature, Diseases	11.7%
192	Infantile Colic	11.7%
193	Congenital clubfoot	11.5%
194	Vertical Talus	11.5%
195	Hyperandrogenism	11.5%
196	Sickle Cell Trait	11.3%
197	Myotonia Congenita	11.1%
198	Aortic coarctation	10.9%
199	Cor Triatriatum	10.9%
200	Coronary Vessel Anomalies	10.9%
201	Dental Enamel Hypoplasia	10.9%
202	Patent ductus arteriosus	10.9%
203	Ebstein Anomaly	10.9%
204	Heart Septal Defects	10.9%
205	Hypodontia	10.9%
206	Macrostomia	10.9%
207	Microstomia	10.9%
208	Tetralogy of Fallot	10.9%
209	Transposition of Great Vessels	10.9%
210	Hypoplastic Left Heart Syndrome	10.9%
211	May-Thurner Syndrome	10.9%
212	Wolff-Parkinson-White Syndrome	10.8%
213	Dystonia Musculorum Deformans	10.8%
214	Familial Mediterranean Fever	10.7%
215	Glycogen storage disease type II	10.5%
216	Anemia, Neonatal	10.4%
217	Persistent Fetal Circulation Syndrome	10.4%
218	Welander Distal Myopathy	10.3%
219	Umbilical hernia	10.3%
220	Congenital nystagmus	10.3%
221	Lafora Disease	10.2%
222	Unverricht-Lundborg Syndrome	10.2%
223	Optic Atrophy, Hereditary, Leber	10.2%
224	Galactosemias	10.2%
225	Urea Cycle Disorders, Inborn	10.2%
226	Tyrosinemias	10.2%
227	Toxoplasmosis, Congenital	10.1%
228	Long QT Syndrome	9.9%
229	Tricuspid Atresia	9.9%
230	Arrhythmogenic Right Ventricular Dysplasia	9.9%
231	Gonadal Dysgenesis	9.9%
232	Adrenogenital Syndrome	9.9%
233	Ovotesticular Disorders of Sex Development	9.9%
234	Acute Chest Syndrome	9.7%
235	Amino Acid Metabolism, Inborn Errors	9.6%
236	Carbohydrate Metabolism, Inborn Errors	9.6%
237	Metal Metabolism, Inborn Errors	9.6%
238	Progeria	9.6%
239	Lysosomal Storage Diseases	9.6%
240	Cytochrome-c Oxidase Deficiency	9.6%
241	Peroxisomal Disorders	9.6%
242	Neonatal Abstinence Syndrome	9.5%
243	Fetal Growth Retardation	9.3%
244	Fetal Hypoxia	9.3%
245	Fetal Alcohol Spectrum Disorders	9.3%
246	Syphilis, Congenital	9.2%
247	Duane Retraction Syndrome	9.1%
248	Congenital Hypothyroidism	9.1%
249	Gout	9.1%
250	Huntington Disease	9%
251	Hyperphosphaturia	8.8%
252	Familial Periodic Paralysis	8.7%
253	Gaucher Disease	8.7%
254	Brain Diseases, Metabolic, Inborn	8.7%
255	Aortopulmonary Septal Defect	8.7%
256	Double Outlet Right Ventricle	8.7%
257	Endocardial Cushion Defects	8.7%
258	Myocardial bridging	8.7%
259	Aorticopulmonary Septal Defect	8.7%
260	Cutis Laxa	8.7%
261	Homocystinuria	8.7%
262	Retinitis Pigmentosa	8.6%
263	Pigmentary retinopathy	8.6%
264	Leigh Disease	8.6%
265	Porokeratosis	8.6%
266	Keratoderma, Palmoplantar	8.6%
267	Chronic granulomatous disease	8.6%
268	Congenital Hyperinsulinism	8.5%
269	Chorioamnionitis	8.5%
270	Mucopolysaccharidosis III	8.4%
271	Hydrops Fetalis	7.9%
272	Porphyrias, Hepatic	7.9%
273	Tay-Sachs Disease	7.9%
274	Romano-Ward Syndrome	7.9%
275	Peutz-Jeghers Syndrome	7.8%
276	Thrombasthenia	7.8%
277	Antithrombin III Deficiency	7.8%
278	Protein C Deficiency	7.8%
279	Afibrinogenemia	7.8%
280	Factor VII Deficiency	7.8%
281	Factor X Deficiency	7.8%
282	Factor XII Deficiency	7.8%
283	Hemophilia A	7.8%
284	Activated Protein C Resistance	7.8%
285	Factor II deficiency	7.8%
286	Factor VIII Deficiency	7.8%
287	Factor V deficiency	7.8%
288	Factor XI Deficiency	7.8%
289	Hypoprothrombinemias	7.8%
290	Fanconi Anemia	7.8%
291	Denys-Drash Syndrome	7.7%
292	Anemia, Diamond-Blackfan	7.7%
293	Carbamoyl-Phosphate Synthase I Deficiency Disease	7.7%
294	Niemann-Pick Disease, Type C	7.7%
295	Truncus Arteriosus, Persistent	7.6%
296	Friedreich Ataxia	7.5%
297	Multiple Endocrine Neoplasia	7.3%
298	Leukomalacia, Periventricular	7.2%
299	Dermatitis, Atopic	7.2%
300	Ophthalmia Neonatorum	7.1%
301	Arthritis, Gouty	6.9%
302	Alkaptonuria	6.9%
303	Glycogen Storage Disease	6.9%
304	Hypophosphatasia	6.9%
305	Propionic acidemia	6.9%
306	Dihydropyrimidine Dehydrogenase Deficiency	6.9%
307	Cystinosis	6.9%
308	Hypokalemic periodic paralysis	6.7%
309	Arteriovenous fistula	6.7%
310	Paralysis, Obstetric	6.7%
311	Retinopathy of Prematurity	6.7%
312	Behcet Syndrome	6.6%
313	Bronchopulmonary Dysplasia	6.6%
314	Pseudohypoparathyroidism	6.3%
315	Hypolipoproteinemias	6.2%
316	Papillon-Lefevre Disease	6.2%
317	Hyperlipidemia, Familial Combined	6.2%
318	Hyperlipoproteinemia Type III	6.2%
319	Myopathy	6.1%
320	Respiratory Distress Syndrome, Newborn	6%
321	MELAS Syndrome	6%
322	Nephroblastoma	5.7%
323	Lactose Intolerance	5.7%
324	Variegate Porphyria	5.7%
325	Acute intermittent porphyria	5.7%
326	Porphyria Cutanea Tarda	5.7%
327	Familial Hypophosphatemic Rickets	5.7%
328	Hyperhomocysteinemia	5.7%
329	Renal Aminoacidurias	5.6%
330	Fanconi Syndrome	5.6%
331	Pseudohypoaldosteronism	5.6%
332	Liddle Syndrome	5.6%
333	Glycogen Storage Disease Type I	5.6%
334	Glycogen Storage Disease Type V	5.6%
335	Hyperlipoproteinemia Type IV	5.6%
336	Hyperlipoproteinemia Type V	5.6%
337	Nesidioblastosis	5.4%
338	Kernicterus	5.4%
339	Fibromyalgia	5.4%
340	Adenomatous Polyposis Coli	5.3%
341	Multiple Endocrine Neoplasia Type 1	5.2%
342	Renal tubular acidosis	5.2%
343	Multiple System Atrophy	5.1%
344	Hypoalphalipoproteinemias	5.1%
345	Chronic Fatigue Syndrome	5%
346	Stiff-Person Syndrome	4.9%
347	Ophthalmoplegic Migraine	4.8%
348	Restless Legs Syndrome	4.7%
349	Cystinuria	4.6%
350	Polyradiculoneuropathy	4.6%
351	Polyradiculoneuritis	4.6%
352	Contracture	4.5%
353	Osteoarthropathy, Secondary Hypertrophic	4.5%
354	Motor Neuron Disease	4.5%
355	Fasciitis, Plantar	4.5%
356	Subacute Combined Degeneration	4.4%
357	Glycosuria, Renal	4.4%
358	Amyotrophic Lateral Sclerosis	4.4%
359	Hyaline Membrane Disease	4.3%
360	Bone Diseases	4.2%
361	Cranial nerve diseases	4.2%
362	Demyelinating Diseases	4.2%
363	Demyelination	4.2%
364	Fasciitis	4.2%
365	Foot Deformities	4.2%
366	Arthropathy	4.2%
367	Neuromuscular Diseases	4.2%
368	Chronobiology Disorders	4.2%
369	Deformity	4.2%
370	Meningoencephalitis	4.2%
371	Ocular Motility Disorders	4.1%
372	Cyclophoria	4.1%
373	Leukoencephalitis, Acute Hemorrhagic	4.1%
374	Osteochondritis	4%
375	Polymyalgia Rheumatica	4%
376	Metatarsalgia	4%
377	Miller Fisher Syndrome	4%
378	Lewy Body Disease	4%
379	Progressive supranuclear palsy	4%
380	Guillain-Barre Syndrome	4%
381	Spinal Muscular Atrophy	4%
382	Progressive Muscular Atrophy	4%
383	Myelitis, Transverse	3.9%
384	Jaw Diseases	3.8%
385	Trauma, Nervous System	3.8%
386	Parkinson Disease	3.8%
387	Cartilage Diseases	3.8%
388	Foot Diseases	3.8%
389	Nervous System Neoplasms	3.8%
390	Neurologic Manifestations	3.8%
391	Rheumatism	3.8%
392	Chondromalacia	3.8%
393	Neurotoxicity Syndromes	3.8%
394	Striatonigral Degeneration	3.7%
395	Osteoarthritis, Spine	3.7%
396	Neuromyelitis Optica	3.7%
397	Encephalomyelitis	3.7%
398	Myositis	3.7%
399	Prion Diseases	3.7%
400	Autonomic Dysreflexia	3.7%
401	Isaacs syndrome	3.7%
402	Complex Regional Pain Syndromes	3.7%
403	Myotonic Disorders	3.7%
404	Temporomandibular Joint Disorders	3.7%
405	Ischemic contracture	3.6%
406	Pneumocephalus	3.6%
407	Poliomyelitis	3.6%
408	Lambert-Eaton Myasthenic Syndrome	3.6%
409	Opsoclonus-Myoclonus Syndrome	3.6%
410	Sleep Wake Disorders	3.4%
411	Temporomandibular Joint Dysfunction Syndrome	3.4%
412	Shy-Drager Syndrome	3.4%
413	Spinal Cord Injuries	3.4%
414	Leukoencephalopathy, Progressive Multifocal	3.4%
415	Peripheral Nerve Injuries	3.4%
416	Medial Tibial Stress Syndrome	3.4%
417	Dyskinesia, Drug-Induced	3.3%
418	Myasthenia Gravis	3.3%
419	Mitochondrial Myopathies	3.3%
420	Asterixis	3.3%
421	Ballismus	3.3%
422	Muscle Cramp	3.3%
423	Rheumatic Fever	3.3%
424	Eosinophilia-Myalgia Syndrome	3.3%
425	Marchiafava-Bignami Disease	3.3%
426	Epidural Abscess	3.3%
427	Olfactory Nerve Injuries	3.3%
428	Causalgia	3.3%
429	MPTP Poisoning	3.2%
430	Lupus Vasculitis, Central Nervous System	3.2%
431	Encephalomyelitis, Acute Disseminated	3.1%
432	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.1%
433	Sleep Disorders, Circadian Rhythm	3.1%
434	Rheumatoid Arthritis	3%
435	Juvenile arthritis	3%
436	Muscle Weakness	3%
437	Facial Nerve Injuries	3%
438	Botulism	3%
439	Neuroleptic Malignant Syndrome	3%
440	Myelinolysis, Central Pontine	3%
441	Muscle Rigidity	3%
442	Muscle Spasticity	3%
443	Cogwheel Rigidity	3%
444	Nuchal Rigidity	3%
445	Hip Contracture	2.9%
446	Myelitis	2.9%
447	Progressive bulbar palsy	2.9%
448	Periarthritis	2.9%
449	Bulbar palsy	2.9%
450	Ankylosing spondylitis	2.9%
451	Akathisia, Drug-Induced	2.8%
452	Myasthenia Gravis, Autoimmune, Experimental	2.8%
453	Myalgia	2.8%
454	Mitochondrial Encephalomyopathies	2.7%
455	Limbic Encephalitis	2.7%
456	Horner Syndrome	2.7%
457	Epilepsy, Post-Traumatic	2.7%
458	Gigantism	2.6%
459	Spinal Neoplasms	2.6%
460	Spondylitis	2.6%
461	Brain Injuries	2.6%
462	Brain Neoplasms	2.6%
463	Multiple Sclerosis	2.6%
464	Spinal Cord Neoplasms	2.6%
465	Dementia, Vascular	2.6%
466	Brain Hemorrhage, Traumatic	2.6%
467	Arthritis, Psoriatic	2.6%
468	Reflex Sympathetic Dystrophy	2.6%
469	Subdural Effusion	2.6%
470	Polymyositis	2.6%
471	Parkinsonian Disorders	2.6%
472	Osteoarthritis, Knee	2.6%
473	Nocturnal Myoclonus Syndrome	2.6%
474	Arthritis	2.5%
475	Bone Diseases, Developmental	2.5%
476	Brain Diseases	2.5%
477	Bursitis	2.5%
478	Dysautonomia	2.5%
479	Hyperostosis	2.5%
480	Joint Instability	2.5%
481	Meningitis	2.5%
482	Movement Disorders	2.5%
483	Myofascial Pain Syndromes	2.5%
484	Osteitis	2.5%
485	Osteitis Deformans	2.5%
486	Osteochondrosis	2.5%
487	Pachymeningitis	2.5%
488	Rhabdomyolysis	2.5%
489	Spinal Cord Diseases	2.5%
490	Spinal Diseases	2.5%
491	Synovitis	2.5%
492	Joint laxity	2.5%
493	Vagus Nerve Disorder	2.5%
494	Glossopharyngeal Neuralgia	2.5%
495	Polyarthritis	2.5%
496	Abducens Nerve Diseases	2.5%
497	Frozen shoulder	2.5%
498	Heavy Metal Poisoning, Nervous System	2.5%
499	Neuromuscular Junction Diseases	2.5%
500	Patellofemoral Pain Syndrome	2.5%
501	Tauopathies	2.5%
502	Trochlear Nerve Diseases	2.5%
503	Peripheral Nervous System Diseases	2.5%
504	Vasculitis, Central Nervous System	2.5%
505	Jet Lag Syndrome	2.5%
506	Brain Abscess	2.4%
507	Ophthalmoplegia	2.4%
508	External Ophthalmoplegia	2.4%
509	Cerebellar Neoplasms	2.4%
510	Scrapie	2.3%
511	Central Cord Syndrome	2.3%
512	Orbital Myositis	2.3%
513	Presenile dementia	2.3%
514	Senile dementia	2.3%
515	Meningitis, Bacterial	2.3%
516	Meningitis, Fungal	2.3%
517	Pyomyositis	2.3%
518	Arthritis, Reactive	2.3%
519	Chorea	2.3%
520	Rheumatoid Nodule	2.3%
521	Acrodynia	2.3%
522	Bone Diseases, Endocrine	2.3%
523	Central Nervous System Infection	2.3%
524	Optic Neuropathy	2.3%
525	Carotid Artery Injuries	2.3%
526	Bone Diseases, Infectious	2.2%
527	Bone neoplasms	2.2%
528	Compartment syndromes	2.2%
529	Facial Nerve Diseases	2.2%
530	Craniocerebral Trauma	2.2%
531	Maxillary Diseases	2.2%
532	Osteopenia	2.2%
533	Parasomnia	2.2%
534	Tendinitis	2.2%
535	Dyssomnias	2.2%
536	Tendinopathy	2.2%
537	Vocal Cord Paralysis	2.2%
538	Vestibulocochlear Nerve Diseases	2.2%
539	Bone Resorption	2.2%
540	Decerebrate State	2.2%
541	Hemarthrosis	2.2%
542	Hemiparesis	2.2%
543	Meningism	2.2%
544	Paresis	2.2%
545	Seizures	2.2%
546	Sensation Disorders	2.2%
547	Tietze's Syndrome	2.2%
548	Central Nervous System Neoplasms	2.2%
549	Complex partial seizures	2.2%
550	Monoparesis	2.2%
551	Aseptic Necrosis of Bone	2.2%
552	Neurogenic Inflammation	2.2%
553	Gait Disorders, Neurologic	2.2%
554	Neuromuscular Manifestations	2.2%
555	Sweating, Gustatory	2.2%
556	Auriculotemporal Syndrome	2.2%
557	Optic Nerve Glioma	2.2%
558	Meige Syndrome	2.2%
559	Brachial Plexus Neuritis	2.2%
560	Neuralgic Amyotrophy	2.2%
561	Cerebral Ventriculitis	2.2%
562	Tuberculosis, Meningeal	2.2%
563	Amblyopia	2.1%
564	Felty Syndrome	2.1%
565	Paraneoplastic Cerebellar Degeneration	2.1%
566	Cerebrospinal Fluid Otorrhea	2.1%
567	Cerebrospinal Fluid Rhinorrhea	2.1%
568	Neuritis, Autoimmune, Experimental	2.1%
569	Gait Ataxia	2.1%
570	Pituitary Adenoma	2.1%
571	Pituitary Neoplasms	2.1%
572	Alice in Wonderland Syndrome	2.1%
573	Acromegaly	2.1%
574	Brain Death	2.1%
575	Coma, Post-Head Injury	2.1%
576	Pupil Disorders	2%
577	Neurobehavioral Manifestations	2%
578	Alcohol Withdrawal Seizures	2%
579	Paraneoplastic Encephalomyelitis	2%
580	Brain Concussion	2%
581	Kearns-Sayre syndrome	2%
582	Tarsal Tunnel Syndrome	2%
583	Cauda Equina Syndrome	2%
584	Posterior Leukoencephalopathy Syndrome	2%
585	Spondylarthropathies	2%
586	Posterior reversible encephalopathy syndrome	2%
587	Uveomeningoencephalitic Syndrome	2%
588	Sturge-Weber Syndrome	2%
589	Vertigo	2%
590	Alcohol-Induced Disorders, Nervous System	2%
591	Toxoplasmosis, Cerebral	2%
592	Creutzfeldt-Jakob disease	2%
593	Basal Ganglia Cerebrovascular Disease	2%
594	Discitis	2%
595	Brain Injuries, Diffuse	2%
596	Traumatic Brain Injury	2%
597	Cerebellar Ataxia	2%
598	Supratentorial Neoplasms	2%
599	Torticollis	2%
600	Multiple Sclerosis, Chronic Progressive	2%
601	Multiple Sclerosis, Relapsing-Remitting	2%
602	Rheumatoid Vasculitis	1.9%
603	Akathisia	1.9%
604	Restlessness	1.9%
605	Psychomotor Agitation	1.9%
606	Voice Disorders	1.8%
607	Voice Disturbance	1.8%
608	Giant Cell Epulis	1.8%
609	Myoclonic Epilepsy	1.8%
610	Epilepsy, Temporal Lobe	1.8%
611	Epilepsy, Rolandic	1.8%
612	Benign Rolandic Epilepsy	1.8%
613	Musculoskeletal Pain	1.8%
614	Basal Ganglia Hemorrhage	1.8%
615	Carpal Tunnel Syndrome	1.8%
616	Vascular Headaches	1.8%
617	Arthralgia	1.8%
618	Polyarthralgia	1.8%
619	neurofibroma	1.8%
620	Hypoxia-Ischemia, Brain	1.8%
621	Sciatica	1.8%
622	Tardive Dyskinesia	1.8%
623	Persistent Vegetative State	1.8%
624	Tuberculosis, Spinal	1.8%
625	Vertebral Artery Dissection	1.8%
626	Amnesia, Transient Global	1.8%
627	Sicca Syndrome	1.8%
628	Sjogren's Syndrome	1.8%
629	Gait Apraxia	1.8%
630	Subarachnoid Hemorrhage, Traumatic	1.7%
631	Carotid Artery, Internal, Dissection	1.7%
632	Subacute Sclerosing Panencephalitis	1.7%
633	Dermatomyositis	1.7%
634	Ainhum	1.7%
635	Akinetic Mutism	1.7%
636	Anoxic Encephalopathy	1.7%
637	Arachnoiditis	1.7%
638	Basal Ganglia Diseases	1.7%
639	Brain Damage, Chronic	1.7%
640	Bunion	1.7%
641	Cerebellar Diseases	1.7%
642	Dysostoses	1.7%
643	Encephalitis	1.7%
644	Encephalomalacia	1.7%
645	Eosinophilic Granuloma	1.7%
646	Epilepsy	1.7%
647	Fibrodysplasia Ossificans Progressiva	1.7%
648	Hydrocephalus	1.7%
649	Congenital Hydrocephalus	1.7%
650	Hypothalamic Diseases	1.7%
651	Aseptic Meningitis	1.7%
652	Myoglobinuria	1.7%
653	Myositis Ossificans	1.7%
654	Neuritis	1.7%
655	Polyneuritis	1.7%
656	Radiculitis	1.7%
657	Reflex, Abnormal	1.7%
658	Spinal Stenosis	1.7%
659	Spondylosis	1.7%
660	Syringomyelia	1.7%
661	Tenosynovitis	1.7%
662	Thalamic Diseases	1.7%
663	Intracranial Hypertension	1.7%
664	Hyporeflexia	1.7%
665	Hyperreflexia	1.7%
666	Polyneuropathy	1.7%
667	Intervertebral Disc Degeneration	1.7%
668	Mononeuritis	1.7%
669	Aura	1.7%
670	Leukoencephalopathy	1.7%
671	Essential Tremor	1.7%
672	Neuroaxonal Dystrophies	1.7%
673	Familial Tremor	1.7%
674	Headache Disorders	1.7%
675	Mononeuropathies	1.7%
676	Intracranial Hypotension	1.7%
677	Sacroiliitis	1.7%
678	Brachial Plexus Neuropathies	1.7%
679	Radiculopathy	1.7%
680	Mononeuropathy Multiplex	1.7%
681	Nerve Root Compression	1.7%
682	Brain Edema	1.7%
683	Brain Hypoxia	1.7%
684	Aqueductal Stenosis	1.7%
685	Pneumorrhachis	1.7%
686	Writer's Cramp	1.7%
687	Putaminal Hemorrhage	1.6%
688	Palatal Neoplasms	1.6%
689	Meningitis, Cryptococcal	1.6%
690	Acoustic Neuroma	1.6%
691	Meningitis, Listeria	1.6%
692	Cubital Tunnel Syndrome	1.6%
693	Juvenile Myoclonic Epilepsy	1.6%
694	Myoclonic Epilepsies, Progressive	1.6%
695	Meningitis, Haemophilus	1.6%
696	Meningitis, Pneumococcal	1.6%
697	Frontotemporal dementia	1.6%
698	Diffuse Axonal Injury	1.6%
699	Brain Stem Neoplasms	1.6%
700	Infarction, Middle Cerebral Artery	1.6%
701	Infarction, Anterior Cerebral Artery	1.6%
702	Infarction, Posterior Cerebral Artery	1.6%
703	Giant Cell Arteritis	1.5%
704	Temporal Arteritis	1.5%
705	Auditory Perceptual Disorders	1.5%
706	Pituitary Apoplexy	1.5%
707	Brain Contusion	1.5%
708	Brain Infarction	1.5%
709	Arthritis, Infectious	1.5%
710	Brain Diseases, Metabolic	1.5%
711	Cerebrovascular Disorders	1.5%
712	Optic Atrophy	1.5%
713	Optic Neuritis	1.5%
714	Papilledema	1.5%
715	Strabismus	1.5%
716	Tolosa-Hunt Syndrome	1.5%
717	Cerebrovascular Insufficiency	1.5%
718	Arsenic Poisoning	1.5%
719	Dementia	1.5%
720	Central Nervous System Fungal Infections	1.5%
721	Conus Medullaris Syndrome	1.5%
722	Spinal Cord Vascular Diseases	1.5%
723	Anterior Compartment Syndrome	1.5%
724	Diabetic Neuropathies	1.5%
725	Facial Injuries	1.5%
726	Facial Neuralgia	1.5%
727	Osteomyelitis	1.5%
728	Osteoporosis	1.5%
729	Periostitis	1.5%
730	Enthesopathy	1.5%
731	Bone Demineralization, Pathologic	1.5%
732	Diabetic Amyotrophy	1.5%
733	Diabetic Autonomic Neuropathy	1.5%
734	Sleep Talking	1.5%
735	Manganese Poisoning	1.5%
736	Post-Traumatic Osteoporosis	1.5%
737	Sleep Disorders, Intrinsic	1.5%
738	Arthritis, Experimental	1.5%
739	Abdominal Compartment Syndrome	1.5%
740	Orthostatic intolerance	1.5%
741	Alveolar Bone Loss	1.5%
742	Anosmia	1.5%
743	Ataxia	1.5%
744	Athetosis	1.5%
745	Catalepsy	1.5%
746	Dystonia	1.5%
747	Femur Head Necrosis	1.5%
748	Hemiplegia	1.5%
749	Locked-In Syndrome	1.5%
750	Meningeal Neoplasms	1.5%
751	Muscle Hypertonia	1.5%
752	Muscle hypotonia	1.5%
753	Myoclonus	1.5%
754	Myotonia	1.5%
755	Neuralgia	1.5%
756	Paraplegia	1.5%
757	Pseudobulbar Palsy	1.5%
758	Quadriplegia	1.5%
759	Spasm	1.5%
760	Spastic Paraplegia	1.5%
761	Status Epilepticus	1.5%
762	Taste Disorders	1.5%
763	Tremor	1.5%
764	Monoplegia	1.5%
765	Hypokinesia	1.5%
766	Paraparesis	1.5%
767	Bradykinesia	1.5%
768	Waxy flexibility	1.5%
769	Action Tremor	1.5%
770	Resting Tremor	1.5%
771	Dysosmia	1.5%
772	Quadriparesis	1.5%
773	Mercury Poisoning, Nervous System	1.5%
774	Olfaction Disorders	1.5%
775	Myokymia	1.5%
776	Lead Poisoning, Nervous System	1.5%
777	Vestibular Neuronitis	1.5%
778	Somatosensory Disorders	1.5%
779	Neuropathic pain	1.5%
780	Hyperkinesia	1.5%
781	Intention tremor	1.5%
782	Osteolysis	1.5%
783	Choroid Plexus Papilloma	1.5%
784	West Nile Fever	1.4%
785	Hand-Arm Vibration Syndrome	1.4%
786	Alexia	1.4%
787	Dyslexia	1.4%
788	Vision Disorders	1.3%
789	Metamorphopsia	1.3%
790	Visual Impairment	1.3%
791	Hip Dislocation	1.3%
792	Shoulder Dislocation	1.3%
793	Optic Neuropathy, Ischemic	1.3%
794	Anterior Ischemic Optic Neuropathy	1.3%
795	Central Nervous System Bacterial Infections	1.3%
796	Hip Dysplasia	1.3%
797	Facial Hemiatrophy	1.3%
798	Melkersson-Rosenthal Syndrome	1.3%
799	Cerebral Infarction	1.3%
800	Brain Stem Infarctions	1.3%
801	Anisocoria	1.3%
802	Confusion	1.3%
803	Facial paralysis	1.3%
804	Lethargy	1.3%
805	Memory Disorders	1.3%
806	Perceptual Disorders	1.3%
807	Psychomotor Disorders	1.3%
808	Tonic Pupil	1.3%
809	Anhedonia	1.3%
810	Disorientation	1.3%
811	Facial Paresis	1.3%
812	Memory Loss	1.3%
813	Hemisensory Neglect	1.3%
814	Dysacusis	1.3%
815	Dupuytren Contracture	1.3%
816	Sleep Bruxism	1.3%
817	Muscular Atrophy	1.3%
818	Respiratory Paralysis	1.3%
819	Joint Tuberculosis	1.3%
820	Tuberculosis, Osteoarticular	1.3%
821	Bone Tuberculosis	1.3%
822	Tetany	1.3%
823	Hematoma, Subdural	1.3%
824	Hematoma, Epidural, Cranial	1.3%
825	Moyamoya Disease	1.3%
826	Neurofibrosarcoma	1.3%
827	Lateral Medullary Syndrome	1.3%
828	Cerebral Palsy	1.2%
829	Chondrodysplasia Punctata	1.2%
830	Enchondromatosis	1.2%
831	Epilepsies, Partial	1.2%
832	Epilepsy, Generalized	1.2%
833	Lordosis	1.2%
834	Osteosclerosis	1.2%
835	Pseudotumor Cerebri	1.2%
836	Spondylolysis	1.2%
837	Sciatic Neuropathy	1.2%
838	Hypertensive Encephalopathy	1.2%
839	Ulnar Neuropathies	1.2%
840	Lesion of Sciatic Nerve	1.2%
841	Simple Partial Seizures	1.2%
842	Epilepsy, Reflex	1.2%
843	Ulnar Neuritis	1.2%
844	Radial nerve compression	1.2%
845	Radial Tunnel Syndrome	1.2%
846	Peroneal Neuropathies	1.2%
847	Radial Neuropathy	1.2%
848	Median Neuropathy	1.2%
849	Sciatic Nerve Palsy	1.2%
850	Femoral Neuropathy	1.2%
851	Tibial Neuropathy	1.2%
852	Ulnar Nerve Palsy	1.2%
853	Postural Orthostatic Tachycardia Syndrome	1.2%
854	Radial nerve palsy	1.2%
855	Headache Disorders, Primary	1.2%
856	Headache Disorders, Secondary	1.2%
857	kyphosis	1.2%
858	Medication overuse headache	1.2%
859	Kashin-Beck Disease	1.2%
860	Consciousness Disorders	1.2%
861	Mental Retardation	1.2%
862	Depressed Level of Consciousness	1.2%
863	Mental deficiency	1.2%
864	Intellectual Disability	1.2%
865	Bell Palsy	1.2%
866	Catatonia	1.2%
867	Herpes Zoster Oticus	1.2%
868	Aphonia	1.2%
869	Sleep Deprivation	1.2%
870	Dysphonia	1.2%
871	Rickets	1.2%
872	Shoulder Pain	1.2%
873	Hematoma, Subdural, Intracranial	1.2%
874	Hematoma, Subdural, Chronic	1.2%
875	Hematoma, Subdural, Acute	1.2%
876	Pituitary Diseases	1.1%
877	Thoracic Outlet Syndrome	1.1%
878	Carotid Artery Diseases	1.1%
879	Brain Ischemia	1.1%
880	Esotropia	1.1%
881	Exotropia	1.1%
882	Hypotension, Orthostatic	1.1%
883	Sleep Apnea Syndromes	1.1%
884	Cerebrovascular accident	1.1%
885	Kluver-Bucy Syndrome	1.1%
886	Vasospasm, Intracranial	1.1%
887	Spinal Cord Ischemia	1.1%
888	Intracranial Arterial Diseases	1.1%
889	Post-Exercise Hypotension	1.1%
890	Disorders of Excessive Somnolence	1.1%
891	Sleep Initiation and Maintenance Disorders	1.1%
892	Osteoporosis, Postmenopausal	1.1%
893	Night Terrors	1.1%
894	Somnambulism	1.1%
895	Trigeminal Nerve Disorder	1.1%
896	Transient Insomnia	1.1%
897	Sleep Paralysis	1.1%
898	Chronic Insomnia	1.1%
899	REM Sleep Behavior Disorder	1.1%
900	Hypersomnia	1.1%
901	Dysgeusia	1.1%
902	Formication	1.1%
903	Hyperalgesia	1.1%
904	Hyperesthesia	1.1%
905	Hypesthesia	1.1%
906	Language Disorders	1.1%
907	Numbness	1.1%
908	Paresthesia	1.1%
909	Paraparesis, Spastic	1.1%
910	Trismus	1.1%
911	Epilepsia Partialis Continua	1.1%
912	Hypogeusia	1.1%
913	Meningeal Carcinomatosis	1.1%
914	Brown-Sequard Syndrome	1.1%
915	Lockjaw	1.1%
916	Allodynia	1.1%
917	Lead Poisoning, Nervous System, Childhood	1.1%
918	Lead Poisoning, Nervous System, Adult	1.1%
919	Ageusia	1.1%
920	Tuberculosis, Central Nervous System	1.1%
921	Melorheostosis	1%
922	Osteopetrosis	1%
923	Polyradiculopathy	1%
924	Post-Traumatic Headache	1%
925	Tension Headache	1%
926	Spondylolisthesis	1%
927	Epilepsy, Complex Partial	1%
928	Migraine Disorders	1%
929	Abdominal Migraine	1%
930	Status Migrainosus	1%
931	Cervicogenic Headache	1%
932	Hoarseness	1%
933	Alcohol Withdrawal Delirium	1%
934	Eye Injuries	1%
935	Diplopia	1%
936	Scotoma	1%
937	Photophobia	1%
938	Hemifacial Spasm	1%
939	Amaurosis	1%
940	Blindness	1%
941	Reye Syndrome	1%
942	Neuroaspergillosis	1%
943	Intracranial Embolism and Thrombosis	1%
944	Hepatic Encephalopathy	1%
945	Agnosia	1%
946	Apraxias	1%
947	Hallucinations	1%
948	Hemianopsia	1%
949	Hyperacusis	1%
950	Tinnitus	1%
951	Visual Agnosia	1%
952	Anosognosia	1%
953	Wernicke-Korsakoff Syndrome	1%
954	Phonophobia	1%
955	Hearing Loss	1%
956	Mastoiditis	1%
957	Petrositis	1%
958	Sarcopenia	1%
959	Waterhouse-Friderichsen Syndrome	1%
960	Cluster Headache	0.9%
961	Pseudorabies	0.9%
962	Migraine with Aura	0.9%
963	Familial Hemiplegic Migraine	0.9%
964	Chronic Paroxysmal Hemicrania	0.9%
965	SUNCT Syndrome	0.9%
966	Paroxysmal Hemicrania	0.9%
967	Empty Sella Syndrome	0.9%
968	Hyperpituitarism	0.9%
969	Hypopituitarism	0.9%
970	Hypophysitis	0.9%
971	Cerebral Arterial Diseases	0.9%
972	Vertebrobasilar Insufficiency	0.9%
973	Anterior Spinal Artery Syndrome	0.9%
974	Basilar Artery Stenosis	0.9%
975	Vertebral Artery Stenosis	0.9%
976	Sleep Apnea, Obstructive	0.9%
977	Sleep Apnea, Central	0.9%
978	Intracranial Hemorrhage, Hypertensive	0.9%
979	Transient Cerebral Ischemia	0.9%
980	Narcolepsy	0.9%
981	Trigeminal Neuralgia	0.9%
982	Kleine-Levin Syndrome	0.9%
983	Agraphia	0.9%
984	Anomia	0.9%
985	Cluttering	0.9%
986	Language Development Disorders	0.9%
987	Speech Disorders	0.9%
988	Syncope	0.9%
989	Stupor	0.9%
990	Dysgraphia	0.9%
991	Presyncope	0.9%
992	Dyslalia	0.9%
993	Amnesia	0.9%
994	Delirium	0.9%
995	Dissociative Amnesia	0.9%
996	Color blindness	0.9%
997	Global Amnesia	0.9%
998	Meningioma	0.9%
999	Neurosyphilis	0.9%
1000	Osteomalacia	0.9%
1001	Eye Burns	0.8%
1002	Malaria, Cerebral	0.8%
1003	Wernicke Encephalopathy	0.8%
1004	Hyperprolactinemia	0.8%
1005	Carotid Stenosis	0.8%
1006	Intracranial Aneurysm	0.8%
1007	AIDS Dementia Complex	0.8%
1008	Neurocysticercosis	0.8%
1009	Amaurosis Fugax	0.8%
1010	Blindness, Cortical	0.8%
1011	Dyscalculia	0.8%
1012	Intracranial Arteriosclerosis	0.8%
1013	Cerebral Atherosclerosis	0.8%
1014	Subarachnoid Hemorrhage	0.8%
1015	Cerebral Arteriosclerosis	0.8%
1016	Cerebral Hemorrhage	0.8%
1017	Subclavian Steal Syndrome	0.8%
1018	Pick Disease of the Brain	0.8%
1019	Phantom pain	0.8%
1020	Phantom Limb Pain	0.8%
1021	Cerebral Thrombosis	0.8%
1022	Intracranial Embolism	0.8%
1023	Intracranial Thrombosis	0.8%
1024	Cataplexy	0.8%
1025	Aphasia	0.8%
1026	Articulation Disorders	0.8%
1027	Deafness	0.8%
1028	Hearing Loss, Sudden	0.8%
1029	Echolalia	0.8%
1030	Gerstmann Syndrome	0.8%
1031	Hearing Loss, Bilateral	0.8%
1032	Hearing Loss, High-Frequency	0.8%
1033	Stuttering	0.8%
1034	Hearing Loss, Mixed Conductive-Sensorineural	0.8%
1035	Prosopagnosia	0.8%
1036	Apraxia, Ideomotor	0.8%
1037	Charles Bonnet Syndrome	0.8%
1038	Hearing Loss, Unilateral	0.8%
1039	Complete Hearing Loss	0.8%
1040	Lyme Neuroborreliosis	0.8%
1041	Dysphasia	0.8%
1042	Alien Hand Syndrome	0.8%
1043	Deaf Mutism	0.8%
1044	Dysarthria	0.8%
1045	Corneal Scar	0.8%
1046	Retrograde amnesia	0.7%
1047	Amnesia, Anterograde	0.7%
1048	Carotid Artery Thrombosis	0.7%
1049	Mutism	0.7%
1050	Selective Mutism	0.7%
1051	Cerebral Amyloid Angiopathy	0.7%
1052	Sinus Thrombosis, Intracranial	0.7%
1053	Nose Neoplasms	0.7%
1054	Renal Osteodystrophy	0.7%
1055	Renal rickets	0.7%
1056	Alexia, Pure	0.7%
1057	Cavernous Sinus Thrombosis	0.7%
1058	Sagittal Sinus Thrombosis	0.7%
1059	Radicular Cyst	0.7%
1060	Corneal Perforation	0.7%
1061	Nelson Syndrome	0.6%
1062	Prolactinoma	0.6%
1063	Growth Hormone-Secreting Pituitary Adenoma	0.6%

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