MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Ichthyosis, X-Linked

(UMLS:C0079588)

Definition:: Chronic form of ichthyosis that is inherited as a sex-linked recessive trait carried on the X-chromosome and transmitted to the male offspring. It is characterized by severe scaling, especially on the extremities, and is associated with steroid sulfatase deficiency.
UMLS ID:: C0079588
MeSH ID:: D016114

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.831.512.420|C16.320.322.241|C16.320.565.925.400|C16.320.850.408|C16.614.492.420

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.428.333.420|C17.800.804.512.420|C17.800.827.408

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.648.925.400

Synonym(s)

Ichthyosis, X-Linked

ICHTHYOSIS, X-LINKED

Ichthyosis, X-linked

Ichthyosis, sex-linked, recessive

Sex-linked ichthyosis

X-Linked Ichthyosis

X-linked ichthyosis

X-linked ichthyosis (STS, SSDD)

X-linked ichthyosis with steryl-sulfatase deficiency

10.

X-linked recessive ichthyosis

11.

X-linked; ichthyosis

12.

XRI - X-linked recessive ichthyosis

13.

ichthyosis x-linked

14.

ichthyosis x-linked with steryl-sulfatase deficiency

15.

ichthyosis; X-linked

16.

ssdd

17.

sts

18.

x linked ichthyosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Estriol		9623797 9764665 14641695	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Sjogren-Larsson Syndrome	58.2%
2	Epidermolysis Bullosa	49.4%
3	Xeroderma Pigmentosum	48.5%
4	Ectodermal Dysplasia	48%
5	Aplasia Cutis Congenita	48%
6	Hyperkeratosis, Epidermolytic	44.4%
7	Albinism	44%
8	Pseudoxanthoma Elasticum	40.5%
9	Porokeratosis	39.5%
10	Keratoderma, Palmoplantar	39.5%
11	Dermatitis, Atopic	38.1%
12	Smith-Lemli-Opitz Syndrome	35.7%
13	Menkes Kinky Hair Syndrome	35.6%
14	Aicardi's syndrome	33.4%
15	Cutis Laxa	32.5%
16	Mucopolysaccharidosis II	29.9%
17	Nail-Patella Syndrome	29.7%
18	Acrodermatitis	29.6%
19	Gianotti-Crosti Syndrome	29.6%
20	Adrenoleukodystrophy	28.8%
21	Porphyrias, Hepatic	28.2%
22	Papillon-Lefevre Disease	28%
23	Ichthyosis, X-Linked	27.6%
24	Fragile X Syndrome	26.9%
25	Cystic Fibrosis	26.4%
26	Fabry Disease	25.7%
27	Kartagener Syndrome	25.1%
28	Holoprosencephaly	25.1%
29	Refsum Disease	25%
30	Cockayne Syndrome	24.8%
31	Marfan Syndrome	24.7%
32	Pyoderma Gangrenosum	24.7%
33	Hepatolenticular Degeneration	24.2%
34	Muscular Dystrophy, Duchenne	24.2%
35	Beckwith-Wiedemann Syndrome	24.1%
36	Wolf-Hirschhorn Syndrome	24.1%
37	Alstrom Syndrome	23.9%
38	CHARGE Syndrome	23.7%
39	Glycogen storage disease type II	23.6%
40	Galactosemias	23.4%
41	Urea Cycle Disorders, Inborn	23.4%
42	Tyrosinemias	23.4%
43	Antley-Bixler Syndrome Phenotype	23.3%
44	Homocystinuria	23%
45	Zellweger Syndrome	22.7%
46	Behcet Syndrome	22.6%
47	Smith-Magenis syndrome	22.4%
48	Cri-du-Chat Syndrome	22.2%
49	Down Syndrome	22.2%
50	Trisomy 21	22.2%
51	Hyperphosphaturia	21.9%
52	Amino Acid Metabolism, Inborn Errors	21.8%
53	Carbohydrate Metabolism, Inborn Errors	21.8%
54	Metal Metabolism, Inborn Errors	21.8%
55	Progeria	21.8%
56	Lysosomal Storage Diseases	21.8%
57	Peroxisomal Disorders	21.8%
58	Leigh Disease	21.5%
59	Rubinstein-Taybi Syndrome	21.5%
60	Werner Syndrome	21.3%
61	Prader-Willi Syndrome	21.1%
62	Wiskott-Aldrich Syndrome	21%
63	Brain Diseases, Metabolic, Inborn	20.7%
64	Amyloid Neuropathies, Familial	20.4%
65	Anemia, Sickle Cell	20.2%
66	Thalassemia	20.2%
67	Mucopolysaccharidosis III	20.1%
68	Xeroderma	20.1%
69	Variegate Porphyria	20.1%
70	Acute intermittent porphyria	20.1%
71	Porphyria Cutanea Tarda	20.1%
72	Neuronal Ceroid-Lipofuscinoses	20%
73	Gaucher Disease	19.9%
74	Angioedemas, Hereditary	19.8%
75	Osteogenesis Imperfecta	19.8%
76	Lupus Erythematosus, Cutaneous	19.3%
77	Panniculitis	19.3%
78	Systemic Scleroderma	19.3%
79	Morphea	19.3%
80	Necrobiosis Lipoidica Diabeticorum	19.2%
81	Rett Syndrome	19%
82	Neoplastic Syndromes, Hereditary	19%
83	Carbamoyl-Phosphate Synthase I Deficiency Disease	18.9%
84	Multiple Epiphyseal Dysplasia	18.6%
85	Osteochondrodysplasias	18.6%
86	Pelger-Huet Anomaly	18.6%
87	Myasthenic Syndromes, Congenital	18.6%
88	Cytochrome-c Oxidase Deficiency	18.2%
89	Acne Vulgaris	17.9%
90	Contact Dermatitis	17.9%
91	Eczema	17.9%
92	Erythema Multiforme	17.9%
93	Intertrigo	17.9%
94	Neurodermatitis	17.9%
95	Rhinophyma	17.9%
96	Perioral Dermatitis	17.9%
97	Acne	17.9%
98	Erythema Induratum	17.6%
99	Tay-Sachs Disease	17.4%
100	Dwarfism	17.4%
101	Tuberous Sclerosis	17.3%
102	Niemann-Pick Disease, Type C	17.3%
103	Panniculitis, Lupus Erythematosus	17.1%
104	Dermatitis, Phototoxic	17.1%
105	Pityriasis Lichenoides et Varioliformis Acuta	17.1%
106	Pityriasis Lichenoides	17.1%
107	Phototoxicity	17.1%
108	Lipomatosis	17.1%
109	Muscular Dystrophy	17%
110	Skin Abnormalities	16.9%
111	Dermatitis Herpetiformis	16.5%
112	Kallmann Syndrome	16.5%
113	Sebaceous Gland Neoplasms	16.4%
114	Myotonic Dystrophy	16.4%
115	Mobius Syndrome	16.3%
116	Dermatomyositis	16.3%
117	Meconium Aspiration Syndrome	16.2%
118	Canavan Disease	16.2%
119	Alexander Disease	16.2%
120	Pseudohypoparathyroidism	16.2%
121	Polycystic Kidney Diseases	16.1%
122	Williams Syndrome	16.1%
123	Autoimmune Lymphoproliferative Syndrome	15.9%
124	Breast Diseases	15.8%
125	Dermatitis	15.8%
126	Exanthema	15.8%
127	Facial Dermatoses	15.8%
128	Hair Diseases	15.8%
129	Hand Dermatoses	15.8%
130	keratoacanthoma	15.8%
131	Nail Diseases	15.8%
132	Photosensitivity Disorders	15.8%
133	Prurigo	15.8%
134	Pyoderma	15.8%
135	Rosacea	15.8%
136	Sebaceous Gland Diseases	15.8%
137	Skin Diseases, Vesiculobullous	15.8%
138	Skin Ulcer	15.8%
139	Sweat Gland Diseases	15.8%
140	Skin Diseases, Papulosquamous	15.8%
141	Skin Diseases, Vascular	15.8%
142	Acneiform Eruptions	15.8%
143	Ocular Rosacea	15.8%
144	Subcorneal pustular dermatosis	15.8%
145	Erythematotelangiectatic Rosacea	15.8%
146	Papulopustular Rosacea	15.8%
147	Chronic Actinic Dermatitis	15.8%
148	Dermatitis, Photoallergic	15.8%
149	Hypolipoproteinemias	15.5%
150	Hyperhomocysteinemia	15.4%
151	Classical Lissencephalies and Subcortical Band Heterotopias	15.3%
152	Chronic granulomatous disease	15.3%
153	Retinal Dysplasia	15.3%
154	Aniridia	15.2%
155	Foot Ulcer	15.2%
156	Familial Hypophosphatemic Rickets	15.2%
157	Alkaptonuria	15.1%
158	Glycogen Storage Disease	15.1%
159	Hypophosphatasia	15.1%
160	Propionic acidemia	15.1%
161	Dihydropyrimidine Dehydrogenase Deficiency	15.1%
162	Cystinosis	15.1%
163	Lactose Intolerance	15.1%
164	Hyperlipidemia, Familial Combined	15.1%
165	Hyperlipoproteinemia Type III	14.8%
166	Primary Ciliary Dyskinesia	14.8%
167	Ataxia Telangiectasia	14.7%
168	Fetal Diseases	14.7%
169	Foot Diseases	14.7%
170	Hyperlipoproteinemia Type IV	14.6%
171	Hyperlipoproteinemia Type V	14.6%
172	Sickle Cell Trait	14.5%
173	Skin Diseases, Infectious	14.5%
174	Skin Neoplasms	14.5%
175	Pigmentation Disorders	14.5%
176	Pruritus	14.4%
177	Erythema	14.4%
178	Necrolytic Migratory Erythema	14.4%
179	Cutaneous Fistula	14.4%
180	Nephrogenic Fibrosing Dermopathy	14.4%
181	Nephrogenic Systemic Fibrosis	14.4%
182	Urticaria Pigmentosa	13.9%
183	Cholesteatoma	13.8%
184	Parakeratosis	13.8%
185	Peutz-Jeghers Syndrome	13.7%
186	Toxic Epidermal Necrolysis	13.7%
187	Stevens-Johnson Syndrome	13.7%
188	Optic Atrophy, Hereditary, Leber	13.7%
189	Renal tubular acidosis	13.2%
190	Congenital Hyperinsulinism	13.2%
191	Abdominal Cramps	13.2%
192	Amniotic Band Syndrome	13.2%
193	Asphyxia Neonatorum	13.2%
194	Infant, Premature, Diseases	13.2%
195	Infantile Colic	13.2%
196	Mastocytosis	13.2%
197	Lipodystrophy	13.2%
198	Familial Mediterranean Fever	13.1%
199	Deformity	13%
200	Erythema Infectiosum	12.9%
201	Exanthema Subitum	12.9%
202	Familial Periodic Paralysis	12.9%
203	Erythema Nodosum	12.8%
204	Renal Aminoacidurias	12.8%
205	Fanconi Syndrome	12.8%
206	Pseudohypoaldosteronism	12.8%
207	Liddle Syndrome	12.8%
208	Acute Chest Syndrome	12.7%
209	Actinic keratosis	12.6%
210	Abnormalities, Drug-Induced	12.5%
211	Situs Inversus	12.5%
212	Dermatitis, Irritant	12.5%
213	Acne Conglobata	12.5%
214	Fanconi Anemia	12.3%
215	Hypoalphalipoproteinemias	12%
216	Anemia, Neonatal	12%
217	Persistent Fetal Circulation Syndrome	12%
218	Gout	12%
219	Umbilical hernia	12%
220	Lupus Erythematosus, Discoid	11.9%
221	Scleroderma, Limited	11.9%
222	Turner Syndrome	11.9%
223	Ecthyma	11.9%
224	Glycogen Storage Disease Type I	11.8%
225	Glycogen Storage Disease Type V	11.8%
226	Tinea Capitis	11.7%
227	Onychomycosis	11.7%
228	Basal Cell Nevus Syndrome	11.6%
229	Dermatitis, Occupational	11.6%
230	Eye Abnormalities	11.6%
231	Cardiovascular Abnormalities	11.6%
232	Glycosuria, Renal	11.6%
233	Polycystic Kidney, Autosomal Dominant	11.5%
234	Lymphatic Abnormalities	11.5%
235	Congenital Microtia	11.5%
236	Dermatitis, Allergic Contact	11.4%
237	Congenital diaphragmatic hernia	11.4%
238	Anencephaly	11.2%
239	Neonatal Abstinence Syndrome	11.1%
240	MELAS Syndrome	11.1%
241	Noonan Syndrome	11%
242	Retinitis Pigmentosa	11%
243	Congenital nystagmus	11%
244	Pigmentary retinopathy	11%
245	Toxoplasmosis, Congenital	10.9%
246	Syphilis, Congenital	10.9%
247	Keratosis	10.9%
248	Welander Distal Myopathy	10.9%
249	Adiposis Dolorosa	10.7%
250	Charcot-Marie-Tooth Disease	10.7%
251	Urogenital Abnormalities	10.7%
252	Maxillofacial Abnormalities	10.4%
253	Dural Arteriovenous Fistula	10.4%
254	Erythema Chronicum Migrans	10.4%
255	Dextrocardia	10.4%
256	Klinefelter Syndrome	10.2%
257	Duane Retraction Syndrome	10.2%
258	Granuloma Annulare	10.1%
259	Myotonia Congenita	10.1%
260	Thrombasthenia	10.1%
261	Antithrombin III Deficiency	10.1%
262	Protein C Deficiency	10.1%
263	Afibrinogenemia	10.1%
264	Dystonia Musculorum Deformans	10.1%
265	Factor VII Deficiency	10.1%
266	Factor X Deficiency	10.1%
267	Factor XII Deficiency	10.1%
268	Hemophilia A	10.1%
269	Activated Protein C Resistance	10.1%
270	Factor II deficiency	10.1%
271	Factor VIII Deficiency	10.1%
272	Factor V deficiency	10.1%
273	Factor XI Deficiency	10.1%
274	Hypoprothrombinemias	10.1%
275	Lafora Disease	10%
276	Unverricht-Lundborg Syndrome	10%
277	Hypokalemic periodic paralysis	10%
278	Anemia, Diamond-Blackfan	10%
279	Cystinuria	10%
280	Bloom Syndrome	9.9%
281	Anhidrosis	9.8%
282	Pressure Ulcer	9.8%
283	Folliculitis	9.8%
284	Foot Dermatoses	9.8%
285	Gynecomastia	9.8%
286	Hypertrichosis	9.8%
287	Hypohidrosis	9.8%
288	Hypotrichosis	9.8%
289	Leg Ulcer	9.8%
290	Miliaria	9.8%
291	Parapsoriasis	9.8%
292	Pityriasis	9.8%
293	Psoriasis	9.8%
294	Sweet Syndrome	9.8%
295	Hidradenitis	9.8%
296	Onycholysis	9.8%
297	Miliaria Rubra	9.8%
298	Hyperpigmentation	9.8%
299	Lichenoid Eruptions	9.8%
300	Chloracne	9.8%
301	Hidradenitis Suppurativa	9.8%
302	Diaper Rash	9.8%
303	Multiple Endocrine Neoplasia	9.5%
304	Congenital Hypothyroidism	9.4%
305	Connective Tissue Diseases	9.4%
306	Arthritis, Gouty	9.3%
307	Acrocephalosyndactylia	9.2%
308	Scimitar Syndrome	9.1%
309	Acantholysis	9%
310	Breast Cyst	9%
311	Pemphigoid, Benign Mucous Membrane	9%
312	Pemphigus	9%
313	Piedra	9%
314	Sunburn	9%
315	Argyria	9%
316	Hirsutism	9%
317	Lactation Disorder	9%
318	Mastitis	9%
319	Urticaria	9%
320	Abnormalities, Radiation-Induced	8.9%
321	Pruritus Vulvae	8.9%
322	Mastocytoma	8.9%
323	Pruritus Ani	8.9%
324	Friedreich Ataxia	8.8%
325	Nesidioblastosis	8.8%
326	Ophthalmia Neonatorum	8.7%
327	Tinea Pedis	8.7%
328	Mycetoma	8.6%
329	Hydrops Fetalis	8.5%
330	Dermatomycoses	8.3%
331	Mucocutaneous Lymph Node Syndrome	8.3%
332	Skin Diseases, Bacterial	8.3%
333	Drug Eruptions	8.2%
334	Livedo Reticularis	8.2%
335	Malignant Atrophic Papulosis	8.2%
336	Huntington Disease	8.2%
337	Polyarteritis Nodosa	8.2%
338	Takayasu Arteritis	8.2%
339	Laryngomalacia	8.1%
340	Pectus carinatum	8.1%
341	Craniosynostosis	7.9%
342	Syndactyly	7.9%
343	Brachycephaly	7.9%
344	Prune Belly Syndrome	7.9%
345	Twins, Conjoined	7.9%
346	Waardenburg Syndrome	7.9%
347	Paralysis, Obstetric	7.8%
348	Retinopathy of Prematurity	7.8%
349	Bronchopulmonary Dysplasia	7.7%
350	Fetal Growth Retardation	7.7%
351	Kernicterus	7.7%
352	Nephroblastoma	7.7%
353	Fetal Hypoxia	7.7%
354	Fetal Alcohol Spectrum Disorders	7.7%
355	Cleft Palate	7.7%
356	Microcephaly	7.7%
357	Macrocephaly	7.7%
358	CREST Syndrome	7.4%
359	Adenomatous Polyposis Coli	7.2%
360	Anophthalmos	7.2%
361	Anus, Imperforate	7.2%
362	Hydranencephaly	7.2%
363	Microphthalmos	7.2%
364	Neural Tube Defects	7.2%
365	Tethered Cord Syndrome	7.2%
366	Iniencephaly	7.2%
367	Craniorachischisis	7.2%
368	Limb Deformities, Congenital	7.2%
369	Exencephaly	7.2%
370	Septo-Optic Dysplasia	7.2%
371	Craniofacial Abnormalities	7.2%
372	Cortical Dysplasia	7.2%
373	Malformations of Cortical Development	7.2%
374	Anorectal Malformations	7.2%
375	Respiratory Distress Syndrome, Newborn	7.2%
376	HIV-Associated Lipodystrophy Syndrome	7.2%
377	Chorioamnionitis	7.1%
378	Lichen Planus	6.9%
379	Melanosis	6.9%
380	Chloasma	6.9%
381	Pityriasis Rosea	6.9%
382	Pityriasis Rubra Pilaris	6.9%
383	Vitiligo	6.9%
384	Lichen Nitidus	6.9%
385	Multiple Endocrine Neoplasia Type 1	6.8%
386	Porencephaly	6.8%
387	Jaw Abnormalities	6.7%
388	Blepharophimosis	6.6%
389	Laryngostenosis	6.6%
390	Mouth Abnormalities	6.6%
391	Esophageal Atresia	6.6%
392	Intestinal Atresia	6.6%
393	Horseshoe Kidney	6.6%
394	Pectus excavatum	6.6%
395	Klippel-Feil Syndrome	6.6%
396	Gastroschisis	6.6%
397	Synostosis	6.6%
398	Lymphangiectasis, Intestinal	6.6%
399	Leukomalacia, Periventricular	6.5%
400	Denys-Drash Syndrome	6.5%
401	Genetic Diseases, Inborn	6.4%
402	Alopecia	6.3%
403	Sweating, Gustatory	6.3%
404	Androgenetic Alopecia	6.3%
405	Auriculotemporal Syndrome	6.3%
406	Poland Syndrome	6.3%
407	Lice Infestations	6.2%
408	Varicose Ulcer	6.2%
409	Breast Neoplasms, Male	6.2%
410	Triple Negative Breast Neoplasms	6.2%
411	Galactorrhea	6.2%
412	Arthrogryposis	6.2%
413	Choanal Atresia	6.2%
414	Tracheobronchomegaly	6.2%
415	Laryngocele	6.2%
416	Choledochal Cyst	6.1%
417	Hermaphroditism	6.1%
418	Disorders of Sex Development	6.1%
419	Giant Cell Arteritis	6.1%
420	Temporal Arteritis	6.1%
421	Cryptorchidism	6.1%
422	Hypospadias	6.1%
423	Central Nervous System Cysts	6.1%
424	Dandy-Walker Syndrome	6.1%
425	POEMS Syndrome	6%
426	Bronchomalacia	6%
427	Tracheomalacia	6%
428	Wasting Syndrome	6%
429	Larva Migrans	5.8%
430	Leishmaniasis	5.8%
431	Molluscum Contagiosum	5.8%
432	Angioedema	5.8%
433	Onchocerciasis	5.7%
434	Chromoblastomycosis	5.7%
435	Dermatophytosis	5.7%
436	Sporotrichosis	5.7%
437	Tinea	5.7%
438	Tinea Versicolor	5.7%
439	Trichophytosis	5.7%
440	Hyalohyphomycosis	5.7%
441	Acute Generalized Exanthematous Pustulosis	5.7%
442	Bladder Exstrophy	5.7%
443	Epispadias	5.7%
444	Multicystic Dysplastic Kidney	5.6%
445	Micrognathism	5.5%
446	Pierre Robin Syndrome	5.5%
447	Acanthosis Nigricans	5.4%
448	Alopecia Areata	5.4%
449	Lentigo	5.4%
450	Hypercalcemia	5.4%
451	Hypocalcemia	5.4%
452	Milk-Alkali Syndrome	5.4%
453	Warts	5.4%
454	Candidiasis, Chronic Mucocutaneous	5.3%
455	Cutaneous Candidiasis	5.3%
456	Collagen Diseases	5.3%
457	Mixed Connective Tissue Disease	5.3%
458	Mucinoses	5.3%
459	Erysipelas	5.3%
460	Serum Sickness	5.3%
461	Staphylococcal Skin Infections	5.3%
462	Erythrasma	5.3%
463	Carcinoma, Lobular	5.3%
464	Arthritis, Psoriatic	5.3%
465	Hyaline Membrane Disease	5.2%
466	Retrognathia	5.1%
467	Hyperandrogenism	5.1%
468	Amelia	5.1%
469	Arachnodactyly	5.1%
470	Ectopia Cordis	5.1%
471	Ectromelia	5.1%
472	Hemimelia	5.1%
473	Meningomyelocele	5.1%
474	Phocomelia	5.1%
475	Sirenomelia	5.1%
476	Spina Bifida	5.1%
477	Polydactyly	5.1%
478	Brachydactyly	5.1%
479	Plagiocephaly	5.1%
480	Lower Extremity Deformities, Congenital	5.1%
481	Upper Extremity Deformities, Congenital	5.1%
482	Single umbilical artery	5.1%
483	Acid-Base Imbalance	5%
484	Calcium Metabolism Disorders	5%
485	Iron Metabolism Disorders	5%
486	Phosphorus Metabolism Disorders	5%
487	Water-Electrolyte Imbalance	5%
488	Lipid Metabolism Disorders	5%
489	Mitochondrial Diseases	5%
490	Glucose Metabolism Disorders	5%
491	Lichen Planus, Oral	4.9%
492	Cartilage Diseases	4.9%
493	Rheumatism	4.9%
494	Chondromalacia	4.9%
495	Rickets	4.9%
496	Prognathism	4.8%
497	Lupus Erythematosus, Systemic	4.8%
498	Overlap syndrome	4.8%
499	Aortic coarctation	4.6%
500	Cor Triatriatum	4.6%
501	Coronary Vessel Anomalies	4.6%
502	Dental Enamel Hypoplasia	4.6%
503	Patent ductus arteriosus	4.6%
504	Ebstein Anomaly	4.6%
505	Heart Septal Defects	4.6%
506	Hypodontia	4.6%
507	Macrostomia	4.6%
508	Meningocele	4.6%
509	Microstomia	4.6%
510	Tetralogy of Fallot	4.6%
511	Transposition of Great Vessels	4.6%
512	Hypoplastic Left Heart Syndrome	4.6%
513	May-Thurner Syndrome	4.6%
514	Encephalocele	4.6%
515	Craniofacial Dysostosis	4.6%
516	Wolff-Parkinson-White Syndrome	4.6%
517	Blastomycosis	4.6%
518	Osteopenia	4.5%
519	Brain Diseases, Metabolic	4.5%
520	Leishmaniasis, Cutaneous	4.5%
521	Eczema Herpeticum	4.5%
522	Fusariosis	4.5%
523	Dupuytren Contracture	4.4%
524	Rhinoscleroma	4.4%
525	Long QT Syndrome	4.3%
526	Platybasia	4.3%
527	Tricuspid Atresia	4.3%
528	Arrhythmogenic Right Ventricular Dysplasia	4.3%
529	Gonadal Dysgenesis	4.3%
530	Adrenogenital Syndrome	4.3%
531	Ovotesticular Disorders of Sex Development	4.3%
532	Epidermodysplasia Verruciformis	4.2%
533	Herpes Labialis	4.2%
534	Diabetic Foot	4.1%
535	Staphylococcal Scalded Skin Syndrome	4.1%
536	Cellulitis	4.1%
537	Dermal Sinus	4%
538	Spina Bifida Cystica	4%
539	Spina Bifida Occulta	4%
540	Lissencephaly	4%
541	Polymicrogyria	4%
542	Pachygyria	4%
543	Schizencephaly	4%
544	Periventricular Nodular Heterotopia	4%
545	Condylomata Acuminata	3.9%
546	Hereditary Angioedema Type III	3.9%
547	Hereditary Angioedema Types I and II	3.9%
548	Furunculosis	3.9%
549	furuncle	3.9%
550	Impetigo	3.8%
551	Aortopulmonary Septal Defect	3.7%
552	Double Outlet Right Ventricle	3.7%
553	Endocardial Cushion Defects	3.7%
554	Myocardial bridging	3.7%
555	Aorticopulmonary Septal Defect	3.7%
556	carbuncle	3.5%
557	Mitochondrial Encephalomyopathies	3.5%
558	Mandibulofacial Dysostosis	3.4%
559	Romano-Ward Syndrome	3.4%
560	Osteomalacia	3.3%
561	Scleromyxedema	3.3%
562	Truncus Arteriosus, Persistent	3.2%
563	Goldenhar Syndrome	3.2%
564	Nutrition Disorders	3%
565	Mesenteric Panniculitis	3%
566	Panniculitis, Peritoneal	3%
567	Tietze's Syndrome	3%
568	Orbital Cellulitis	3%
569	Myxoid cyst	3%
570	Myxedema	3%
571	Acidosis	3%
572	Alkalosis	3%
573	Amyloidosis	3%
574	Calcinosis	3%
575	Hyperglycemia	3%
576	Hyperinsulinism	3%
577	Hyperkalemia	3%
578	Hypernatremia	3%
579	Hypoglycemia	3%
580	Hypokalemia	3%
581	Hyponatremia	3%
582	Xanthomatosis	3%
583	Hypophosphatemia	3%
584	Metabolic acidosis	3%
585	Dyslipidemias	3%
586	Iron Overload	3%
587	Xanthoma	3%
588	Talipes	3%
589	Arteriovenous fistula	2.9%
590	Diabetic Ketoacidosis	2.9%
591	HIV Wasting Syndrome	2.8%
592	Osteochondritis	2.8%
593	Polymyalgia Rheumatica	2.8%
594	Diabetes Mellitus	2.7%
595	Keloid	2.7%
596	Congenital clubfoot	2.7%
597	Vertical Talus	2.7%
598	Dehydration	2.7%
599	Water Intoxication	2.7%
600	Achlorhydria	2.7%
601	Osteoporosis	2.7%
602	Bone Demineralization, Pathologic	2.7%
603	Post-Traumatic Osteoporosis	2.7%
604	Celiac Disease	2.7%
605	Sprue, Tropical	2.7%
606	Steatorrhea	2.7%
607	Sprue	2.7%
608	Renal Osteodystrophy	2.7%
609	Renal rickets	2.7%
610	Rheumatoid Arthritis	2.6%
611	Juvenile arthritis	2.6%
612	Lupus Nephritis	2.5%
613	Mitochondrial Myopathies	2.5%
614	Myelinolysis, Central Pontine	2.5%
615	Glycosuria	2.5%
616	Reye Syndrome	2.5%
617	Hepatic Encephalopathy	2.5%
618	Wernicke Encephalopathy	2.4%
619	Kearns-Sayre syndrome	2.3%
620	Acidosis, Lactic	2%
621	Calciphylaxis	2%
622	Hemosiderosis	2%
623	Ketosis	2%
624	Ketonuria	2%
625	Ketoacidosis	2%
626	Ketonemia	2%
627	Vascular calcification	2%
628	Rheumatoid Nodule	1.9%
629	Acidosis, Respiratory	1.8%
630	Alkalosis, Respiratory	1.8%
631	Insulin Resistance	1.8%
632	Osteoporosis, Postmenopausal	1.8%
633	Felty Syndrome	1.8%
634	Gestational Diabetes	1.7%
635	Latent Autoimmune Diabetes in Adults	1.7%
636	Child Nutrition Disorders	1.7%
637	Hypervitaminosis A	1.7%
638	Infant Nutrition Disorders	1.7%
639	Malnutrition	1.7%
640	Diabetes Mellitus, Experimental	1.6%
641	Rheumatoid Vasculitis	1.6%
642	Nephrocalcinosis	1.6%
643	Tetany	1.6%
644	Lupus Vasculitis, Central Nervous System	1.6%
645	Cerebral Amyloid Angiopathy	1.6%
646	Sicca Syndrome	1.5%
647	Sjogren's Syndrome	1.5%
648	Primary amyloidosis	1.5%
649	Hypercholesterolemia	1.5%
650	Hyperlipoproteinemias	1.5%
651	Hypertriglyceridemia	1.5%
652	Amyotrophic Lateral Sclerosis	1.4%
653	Frontotemporal dementia	1.1%
654	Deficiency Diseases	1%
655	Starvation	1%
656	Refeeding Syndrome	1%
657	Obesity	0.8%
658	Kwashiorkor	0.7%
659	Magnesium Deficiency	0.7%
660	Potassium Deficiency	0.7%
661	Protein Deficiency	0.7%
662	Avitaminosis	0.7%
663	Obesity, Abdominal	0.5%
664	Pediatric Obesity	0.5%
665	Ascorbic Acid Deficiency	0.5%
666	Vitamin A Deficiency	0.5%
667	Vitamin D Deficiency	0.5%
668	Vitamin E Deficiency	0.5%
669	Marasmus	0.5%
670	Vitamin K Deficiency	0.4%
671	Folic Acid Deficiency	0.4%
672	Pellagra	0.4%
673	Thiamine Deficiency	0.4%
674	Vitamin B 12 Deficiency	0.4%
675	Vitamin B 6 Deficiency	0.4%
676	Pyridoxine Deficiency	0.4%
677	Beriberi	0.4%
678	Scurvy	0.3%
679	Anemia, Pernicious	0.3%
680	Subacute Combined Degeneration	0.3%

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