MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Arteriosclerosis Obliterans

(UMLS:C0003851)

Definition:: Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
UMLS ID:: C0003851
MeSH ID:: D001162

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.137.126.114

Synonym(s)

Arteriosclerosis Obliterans

Arteriosclerosis obliterans

arteriosclerosis obliterans

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Memantine	FAERS: 4		US FAERS
2	Imatinib Mesylate	FAERS: 3		US FAERS
3	Atenolol	FAERS: 2		US FAERS
4	Rivastigmine	FAERS: 2		US FAERS
5	gemcitabine	FAERS: 2		US FAERS
6	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
7	Cilostazol	FAERS: 1		OFFSIDES US FAERS
8	Rosuvastatin Calcium	FAERS: 1		US FAERS
9	paricalcitol	FAERS: 1		OFFSIDES US FAERS
10	Alosenn			OFFSIDES
11	Alprostadil			OFFSIDES
12	Ambroxol			OFFSIDES
13	Benzydamine			OFFSIDES
14	Betaxolol			OFFSIDES
15	Buprenorphine			OFFSIDES
16	Cefdinir			OFFSIDES
17	Clopidogrel			OFFSIDES
18	Diclofenac			OFFSIDES
19	Estrogens, Conjugated (USP)			OFFSIDES
20	Fluorometholone			OFFSIDES
21	Gatifloxacin			OFFSIDES
22	Gentamicins			OFFSIDES
23	Iopamidol			OFFSIDES
24	Isosorbide Dinitrate			OFFSIDES
25	Ketoconazole			OFFSIDES
26	Leuprolide			OFFSIDES
27	Nicorandil			OFFSIDES
28	Nizatidine			OFFSIDES
29	Opalmon			OFFSIDES
30	Perindopril			OFFSIDES
31	Pravastatin			OFFSIDES
32	Rabeprazole			OFFSIDES
33	S 1108			OFFSIDES
34	Sodium ferric gluconate complex			OFFSIDES
35	Sodium picosulfate			OFFSIDES
36	Ticlopidine			OFFSIDES
37	Timolol			OFFSIDES
38	Tiotropium Bromide			OFFSIDES
39	Travoprost			OFFSIDES
40	Trichlormethiazide			OFFSIDES
41	Verapamil			OFFSIDES
42	Warfarin			OFFSIDES
43	alpha-Tocopherol			OFFSIDES
44	amezinium			OFFSIDES
45	azelnidipine			OFFSIDES
46	benazepril			OFFSIDES
47	benidipine			OFFSIDES
48	bicalutamide			OFFSIDES
49	candesartan			OFFSIDES
50	cefpodoxime proxetil			OFFSIDES
51	cefpodoxime			OFFSIDES
52	efonidipine			OFFSIDES
53	eprazinone			OFFSIDES
54	etizolam			OFFSIDES
55	geranylgeranylacetone			OFFSIDES
56	imidapril			OFFSIDES
57	limaprost			OFFSIDES
58	naftopidil			OFFSIDES
59	naphthalan		1891869	CTD
60	nilvadipine			OFFSIDES
61	reviparin			OFFSIDES
62	sarpogrelate		15080020	CTD OFFSIDES
63	urapidil			OFFSIDES
64	voglibose			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Atherosclerosis	48.4%
2	Fibromuscular Dysplasia	34.4%
3	Pulmonary artery stenosis	34.4%
4	Intermittent Claudication	33.3%
5	Leriche Syndrome	33%
6	Thromboangiitis Obliterans	33%
7	Coronary Artery Disease	30.6%
8	Intracranial Arteriosclerosis	28.9%
9	Cerebral Atherosclerosis	28.9%
10	Cerebral Arteriosclerosis	28.9%
11	Aneurysm	25.4%
12	Angiomatosis	25.4%
13	Aortic Diseases	25.4%
14	Hyperemia	25.4%
15	Hypotension	25.4%
16	Superior Vena Cava Syndrome	25.4%
17	Telangiectasis	25.4%
18	Vasculitis	25.4%
19	Venous Insufficiency	25.4%
20	Peripheral Vascular Diseases	25.4%
21	Embolism and Thrombosis	25.4%
22	Angiodysplasia	25.4%
23	Capillary Leak Syndrome	25.4%
24	Prehypertension	25.4%
25	Malignant Atrophic Papulosis	24.8%
26	Retinal Artery Occlusion	23.6%
27	Myocardial Ischemia	23%
28	Carotid Stenosis	21.9%
29	Aortic Aneurysm	19.8%
30	Aortitis	19.8%
31	Periphlebitis	19.8%
32	Phlebitis	19.8%
33	Vascular System Injuries	18.1%
34	Mesenteric Vascular Occlusion	17.6%
35	Compartment syndromes	17.2%
36	Hepatic Veno-Occlusive Disease	17.2%
37	Peliosis Hepatis	17.2%
38	Varicocele	17.2%
39	Renal Artery Obstruction	17.2%
40	Renal Artery Stenosis	17.2%
41	Moyamoya Disease	16.9%
42	Cerebrovascular Disorders	16.9%
43	Diabetic Angiopathies	16.9%
44	Reperfusion Injury	16.9%
45	Splenic Infarction	16.9%
46	Cerebrovascular Insufficiency	16.9%
47	Vascular Neoplasms	16.9%
48	Spinal Cord Vascular Diseases	16.9%
49	Vasoplegia	16.9%
50	Hemorrhoids	16.7%
51	Thoracic Outlet Syndrome	16.7%
52	Retinal Vein Occlusion	16.5%
53	Heart Diseases	16.4%
54	Postphlebitic Syndrome	16.3%
55	Aneurysm, Dissecting	14.8%
56	Arteritis	14.8%
57	Embolism	14.8%
58	Erythromelalgia	14.8%
59	Malignant Hypertension	14.8%
60	Raynaud Disease	14.8%
61	Shwartzman Phenomenon	14.8%
62	Thromboembolism	14.8%
63	Thrombosis	14.8%
64	Essential Hypertension	14.8%
65	Aneurysm, Ruptured	14.8%
66	Iliac Aneurysm	14.8%
67	White Coat Hypertension	14.8%
68	Systemic Vasculitis	14.8%
69	Embolus	14.8%
70	Coronary Aneurysm	13.8%
71	Blue Toe Syndrome	13.7%
72	Hand-Arm Vibration Syndrome	13.3%
73	Thrombophlebitis	13.3%
74	Coronary heart disease	13.2%
75	Myocardial Infarction	13.2%
76	Myocardial Reperfusion Injury	13.2%
77	Acute Coronary Syndrome	13.2%
78	Aortic Aneurysm, Abdominal	12.9%
79	Aortic Aneurysm, Thoracic	12.9%
80	Optic Neuropathy, Ischemic	12.8%
81	Anterior Ischemic Optic Neuropathy	12.8%
82	Mesenteric vascular insufficiency	12.8%
83	Angioedema	12.4%
84	Colitis, Ischemic	12.3%
85	Intracranial Embolism and Thrombosis	12.2%
86	Intracranial Aneurysm	12.1%
87	Aortic Rupture	11.8%
88	Coronary Thrombosis	11.3%
89	Dementia, Vascular	10.9%
90	Pregnancy Complications, Cardiovascular	10.8%
91	Cardiovascular Abnormalities	10.8%
92	Carotid Artery Thrombosis	10.6%
93	Arteriovenous fistula	10.2%
94	Retinal Vasculitis	10.1%
95	Hypertensive Retinopathy	10.1%
96	Kounis Syndrome	10.1%
97	Vasculitis, Central Nervous System	10%
98	Anterior Compartment Syndrome	9.9%
99	Vasculitis, Leukocytoclastic, Cutaneous	9.9%
100	Gastric Antral Vascular Ectasia	9.9%
101	Abdominal Compartment Syndrome	9.9%
102	May-Thurner Syndrome	9.8%
103	Angina Pectoris	9.8%
104	Carotid Artery Diseases	9.8%
105	Brain Ischemia	9.8%
106	Hypotension, Orthostatic	9.8%
107	Cerebrovascular accident	9.8%
108	Varicose Ulcer	9.8%
109	Vasospasm, Intracranial	9.8%
110	Spinal Cord Ischemia	9.8%
111	Intracranial Arterial Diseases	9.8%
112	Primary Graft Dysfunction	9.8%
113	Post-Exercise Hypotension	9.8%
114	Polyarteritis Nodosa	9.8%
115	Takayasu Arteritis	9.8%
116	Air Embolism	9.7%
117	Endarteritis	9.7%
118	Venous Thrombosis	9.7%
119	Deep Vein Thrombosis	9.7%
120	Venous Thromboembolism	9.7%
121	Embolism, Amniotic Fluid	9.2%
122	Scimitar Syndrome	8.7%
123	Coronary Occlusion	8.6%
124	Microvascular Angina	8.6%
125	Coronary Stenosis	8.6%
126	ST segment elevation myocardial infarction	8.6%
127	Cardiac Tamponade	8.5%
128	Endocarditis	8.5%
129	Cardiac Arrest	8.5%
130	Heart failure	8.5%
131	Pericardial effusion	8.5%
132	Pericarditis	8.5%
133	Pneumopericardium	8.5%
134	Cor pulmonale	8.5%
135	Ventricular Outflow Obstruction	8.5%
136	Ventricular Dysfunction	8.5%
137	Cardiomyopathies	8.5%
138	Pleuropericarditis	8.5%
139	Cerebral Thrombosis	8.4%
140	Intracranial Embolism	8.4%
141	Intracranial Thrombosis	8.4%
142	Brain Infarction	7.7%
143	Mucocutaneous Lymph Node Syndrome	7.6%
144	Diabetic Retinopathy	7.5%
145	Sturge-Weber Syndrome	7.5%
146	Livedo Reticularis	7.4%
147	Renal hypertension	7.4%
148	Hemangioma, Cavernous	7.3%
149	Basal Ganglia Cerebrovascular Disease	7.3%
150	Giant Cell Arteritis	7.3%
151	Temporal Arteritis	7.3%
152	Vascular Headaches	7.3%
153	Scurvy	7.3%
154	CREST Syndrome	6.9%
155	Pulmonary Embolism	6.7%
156	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	6.7%
157	Aortic Valve Stenosis	6.6%
158	Cardiomyopathy, Dilated	6.6%
159	Pulmonary Valve Stenosis	6.6%
160	Sinus Thrombosis, Intracranial	6.5%
161	No-Reflow Phenomenon	6.5%
162	Shock, Cardiogenic	6.5%
163	Vertebral Artery Dissection	6.5%
164	Cerebral Arterial Diseases	6.4%
165	Vertebrobasilar Insufficiency	6.4%
166	Anterior Spinal Artery Syndrome	6.4%
167	Basilar Artery Stenosis	6.4%
168	Vertebral Artery Stenosis	6.4%
169	Intracranial Hemorrhage, Hypertensive	6.4%
170	Transient Cerebral Ischemia	6.4%
171	Angina, Unstable	6.4%
172	Coronary Restenosis	6.4%
173	Subarachnoid Hemorrhage, Traumatic	6%
174	Carotid Artery, Internal, Dissection	6%
175	Lemierre Syndrome	6%
176	Ischemic contracture	6%
177	Angioedemas, Hereditary	5.9%
178	Tricuspid Atresia	5.9%
179	Arrhythmogenic Right Ventricular Dysplasia	5.9%
180	Cryoglobulinemia	5.9%
181	Leukomalacia, Periventricular	5.9%
182	Diabetic Foot	5.8%
183	Cardiac Output, High	5.7%
184	Myocardial Stunning	5.7%
185	Low Cardiac Output Syndrome	5.7%
186	Cerebral Infarction	5.7%
187	Brain Stem Infarctions	5.7%
188	Cavernous Sinus Thrombosis	5.6%
189	Sagittal Sinus Thrombosis	5.6%
190	Cardiomegaly	5.6%
191	Postpericardiotomy Syndrome	5.6%
192	Cardiac Hypertrophy	5.6%
193	Carotid Artery Injuries	5.6%
194	Rheumatic Heart Disease	5.5%
195	Bacterial Endocarditis	5.4%
196	Infarction, Middle Cerebral Artery	5.4%
197	Infarction, Anterior Cerebral Artery	5.4%
198	Infarction, Posterior Cerebral Artery	5.4%
199	Hepatic Vein Thrombosis	5%
200	Budd-Chiari Syndrome	5%
201	Heart Block	5%
202	Tachycardia	5%
203	Tachyarrhythmia	5%
204	Aortic coarctation	4.9%
205	Aortic Valve Insufficiency	4.9%
206	Restrictive cardiomyopathy	4.9%
207	Cor Triatriatum	4.9%
208	Coronary Vessel Anomalies	4.9%
209	Patent ductus arteriosus	4.9%
210	Ebstein Anomaly	4.9%
211	Endocardial Fibroelastosis	4.9%
212	Heart Rupture, Post-Infarction	4.9%
213	Heart Septal Defects	4.9%
214	Mitral Valve Insufficiency	4.9%
215	Mitral Valve Stenosis	4.9%
216	Myocarditis	4.9%
217	Pericarditis, Constrictive	4.9%
218	Pulmonary Valve Insufficiency	4.9%
219	Tetralogy of Fallot	4.9%
220	Transposition of Great Vessels	4.9%
221	Tricuspid Valve Insufficiency	4.9%
222	Tricuspid Valve Stenosis	4.9%
223	Hypoplastic Left Heart Syndrome	4.9%
224	Ventricular Dysfunction, Left	4.9%
225	Right Ventricular Dysfunction	4.9%
226	Endomyocardial Fibrosis	4.9%
227	Carditis	4.9%
228	Heart Failure, Systolic	4.9%
229	Heart Failure, Diastolic	4.9%
230	Shy-Drager Syndrome	4.9%
231	Hypertrophic Cardiomyopathy	4.9%
232	Pulmonary Infarction	4.9%
233	Purpura, Hyperglobulinemic	4.9%
234	Hypertrophic obstructive cardiomyopathy	4.9%
235	Hypertension, Renovascular	4.8%
236	Subarachnoid Hemorrhage	4.8%
237	Hypoxia-Ischemia, Brain	4.8%
238	Cerebral Hemorrhage	4.8%
239	Hereditary Angioedema Type III	4.8%
240	Hereditary Angioedema Types I and II	4.8%
241	Basal Ganglia Hemorrhage	4.8%
242	Subclavian Steal Syndrome	4.8%
243	Angina Pectoris, Variant	4.8%
244	Lateral Medullary Syndrome	4.7%
245	Supravalvular aortic stenosis	4.3%
246	Lown-Ganong-Levine Syndrome	4.3%
247	Behcet Syndrome	4.3%
248	Waldenstrom Macroglobulinemia	4.2%
249	Multiple Myeloma	4.2%
250	Dextrocardia	3.9%
251	Long QT Syndrome	3.9%
252	Pituitary Apoplexy	3.9%
253	Ataxia Telangiectasia	3.8%
254	Pseudoxanthoma Elasticum	3.7%
255	Putaminal Hemorrhage	3.7%
256	Granulomatosis with polyangiitis	3.7%
257	Cerebral Amyloid Angiopathy	3.6%
258	Sinus Arrhythmia	3.3%
259	Atrial Fibrillation	3.3%
260	Atrial Flutter	3.3%
261	Edema, Cardiac	3.3%
262	Ventricular Fibrillation	3.3%
263	Ventricular Flutter	3.3%
264	Parasystole	3.3%
265	Paroxysmal atrial fibrillation	3.3%
266	Bradycardia	3.3%
267	Diabetic Cardiomyopathies	3.3%
268	Cardiomyopathy, Alcoholic	3.3%
269	Ectopia Cordis	3.3%
270	Sudden Cardiac Death	3.3%
271	Left Ventricular Hypertrophy	3.3%
272	Right Ventricular Hypertrophy	3.3%
273	Rheumatoid Vasculitis	3.3%
274	Single umbilical artery	3.3%
275	Chagas Cardiomyopathy	3.2%
276	Lupus Vasculitis, Central Nervous System	3.2%
277	Carcinoid Heart Disease	3.2%
278	Adams-Stokes Syndrome	3.2%
279	Aortic Valve Prolapse	3.2%
280	Atrioventricular Block	3.2%
281	Bundle-Branch Block	3.2%
282	Atrial Premature Complexes	3.2%
283	Sick Sinus Syndrome	3.2%
284	Sinoatrial Block	3.2%
285	Tachycardia, Paroxysmal	3.2%
286	Supraventricular tachycardia	3.2%
287	Tricuspid Valve Prolapse	3.2%
288	Tachycardia, Ventricular	3.2%
289	Wolff-Parkinson-White Syndrome	3.2%
290	Tachycardia, Reciprocating	3.2%
291	Takotsubo Cardiomyopathy	3.2%
292	Aortopulmonary Septal Defect	3.2%
293	Double Outlet Right Ventricle	3.2%
294	Endocardial Cushion Defects	3.2%
295	Myocardial bridging	3.2%
296	Aorticopulmonary Septal Defect	3.2%
297	Noonan Syndrome	2.8%
298	Subacute Bacterial Endocarditis	2.7%
299	Romano-Ward Syndrome	2.6%
300	Marfan Syndrome	2.5%
301	Dyspnea, Paroxysmal	2.5%
302	Tachycardia, Atrioventricular Nodal Reentry	2.4%
303	Tachycardia, Ectopic Atrial	2.4%
304	Tachycardia, Ectopic Junctional	2.4%
305	Sinus Tachycardia	2.4%
306	Torsades de Pointes	2.4%
307	Accelerated Idioventricular Rhythm	2.4%
308	Truncus Arteriosus, Persistent	2.4%
309	Sinus Arrest, Cardiac	2.2%
310	Hematoma, Subdural	2.1%
311	Hematoma, Epidural, Cranial	2.1%
312	Dural Arteriovenous Fistula	2%
313	MELAS Syndrome	1.9%
314	Brain Hemorrhage, Traumatic	1.8%
315	Hematoma, Subdural, Intracranial	1.7%
316	Hematoma, Subdural, Chronic	1.7%
317	Hematoma, Subdural, Acute	1.7%
318	Fabry Disease	1.5%
319	Turner Syndrome	1.4%
320	Kartagener Syndrome	1%
321	Williams Syndrome	1%
322	Kearns-Sayre syndrome	0.9%

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