MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Werner Syndrome

(UMLS:C0043119)

Definition:: An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease.
UMLS ID:: C0043119
MeSH ID:: D014898

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.925

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.284.960

Synonym(s)

Werner Syndrome

Adult Progeria

Adult premature ageing syndrome

Adult premature aging syndrome

Adult progeria

PROGERIA, OF ADULT

Pangeria

Progeria of the adult

WERNER SYNDROME

10.

11.

Werner

12.

Werner syndrome

13.

Werner syndrome (adult progeria)

14.

Werner's Syndrome

15.

Werner's syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Resveratrol		20974729	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Cockayne Syndrome	29.3%
2	Bloom Syndrome	28.8%
3	Smith-Lemli-Opitz Syndrome	25.9%
4	Amino Acid Metabolism, Inborn Errors	25.4%
5	Carbohydrate Metabolism, Inborn Errors	25.4%
6	Metal Metabolism, Inborn Errors	25.4%
7	Progeria	25.4%
8	Lysosomal Storage Diseases	25.4%
9	Cytochrome-c Oxidase Deficiency	25.4%
10	Peroxisomal Disorders	25.4%
11	Fanconi Anemia	25.4%
12	Leigh Disease	24%
13	Menkes Kinky Hair Syndrome	23.6%
14	Brain Diseases, Metabolic, Inborn	23.5%
15	Fragile X Syndrome	23.4%
16	Mucopolysaccharidosis II	23.3%
17	Galactosemias	23.3%
18	Urea Cycle Disorders, Inborn	23.3%
19	Tyrosinemias	23.3%
20	Pseudohypoparathyroidism	22.9%
21	Glycogen storage disease type II	22.7%
22	Neuronal Ceroid-Lipofuscinoses	22.6%
23	Albinism	22.3%
24	Carbamoyl-Phosphate Synthase I Deficiency Disease	22.2%
25	Hypolipoproteinemias	21.9%
26	Neoplastic Syndromes, Hereditary	21.8%
27	Ichthyosis, X-Linked	21.3%
28	Gaucher Disease	21.2%
29	Wasting Syndrome	21.1%
30	Hyperhomocysteinemia	21%
31	Acid-Base Imbalance	20.9%
32	Calcium Metabolism Disorders	20.9%
33	Iron Metabolism Disorders	20.9%
34	Phosphorus Metabolism Disorders	20.9%
35	Water-Electrolyte Imbalance	20.9%
36	Lipid Metabolism Disorders	20.9%
37	Mitochondrial Diseases	20.9%
38	Glucose Metabolism Disorders	20.9%
39	Aicardi's syndrome	20.9%
40	Fabry Disease	20.8%
41	Amyloid Neuropathies, Familial	20.8%
42	Hyperlipidemia, Familial Combined	20.8%
43	Adrenoleukodystrophy	20.8%
44	Multiple Epiphyseal Dysplasia	20.7%
45	Osteochondrodysplasias	20.7%
46	Pelger-Huet Anomaly	20.7%
47	Hyperphosphaturia	20.7%
48	Myasthenic Syndromes, Congenital	20.7%
49	CHARGE Syndrome	20.5%
50	Familial Mediterranean Fever	20.5%
51	Hyperlipoproteinemia Type IV	20.4%
52	Hyperlipoproteinemia Type V	20.4%
53	Hypercalcemia	20.3%
54	Hypocalcemia	20.3%
55	Milk-Alkali Syndrome	20.3%
56	Beckwith-Wiedemann Syndrome	20.3%
57	Wolf-Hirschhorn Syndrome	20.3%
58	Hyperlipoproteinemia Type III	20.3%
59	Anemia, Sickle Cell	20.1%
60	Thalassemia	20.1%
61	Alkaptonuria	20%
62	Glycogen Storage Disease	20%
63	Hypophosphatasia	20%
64	Propionic acidemia	20%
65	Dihydropyrimidine Dehydrogenase Deficiency	20%
66	Cystinosis	20%
67	Muscular Dystrophy, Duchenne	19.9%
68	Lactose Intolerance	19.9%
69	Rett Syndrome	19.8%
70	Homocystinuria	19.7%
71	Tay-Sachs Disease	19.6%
72	Ataxia Telangiectasia	19.6%
73	Mucopolysaccharidosis III	19.5%
74	Refsum Disease	19.3%
75	Hepatolenticular Degeneration	19.1%
76	Cystic Fibrosis	18.8%
77	Hypoalphalipoproteinemias	18.7%
78	Niemann-Pick Disease, Type C	18.4%
79	Sjogren-Larsson Syndrome	17.6%
80	Xeroderma Pigmentosum	17.6%
81	Glycogen Storage Disease Type I	17.4%
82	Glycogen Storage Disease Type V	17.4%
83	Alstrom Syndrome	17.3%
84	Zellweger Syndrome	17.3%
85	Nail-Patella Syndrome	17.2%
86	Dwarfism	17.1%
87	Porphyrias, Hepatic	17%
88	Smith-Magenis syndrome	17%
89	Familial Hypophosphatemic Rickets	17%
90	Cri-du-Chat Syndrome	16.8%
91	Down Syndrome	16.8%
92	Trisomy 21	16.8%
93	Sickle Cell Trait	16.4%
94	Muscular Dystrophy	16.3%
95	Osteogenesis Imperfecta	16.3%
96	Lipodystrophy	16.2%
97	Osteopenia	15.8%
98	Prader-Willi Syndrome	15.7%
99	Brain Diseases, Metabolic	15.5%
100	Renal tubular acidosis	15.5%
101	Optic Atrophy, Hereditary, Leber	15.4%
102	Canavan Disease	15.2%
103	Alexander Disease	15.2%
104	Wiskott-Aldrich Syndrome	15%
105	Holoprosencephaly	14.8%
106	Congenital Hyperinsulinism	14.8%
107	Deformity	14.6%
108	Rickets	14.6%
109	Ectodermal Dysplasia	14.4%
110	Aplasia Cutis Congenita	14.4%
111	Kartagener Syndrome	14.1%
112	Autoimmune Lymphoproliferative Syndrome	13.8%
113	Primary Ciliary Dyskinesia	13.8%
114	Antley-Bixler Syndrome Phenotype	13.6%
115	Acidosis	13.6%
116	Alkalosis	13.6%
117	Amyloidosis	13.6%
118	Calcinosis	13.6%
119	Hyperglycemia	13.6%
120	Hyperinsulinism	13.6%
121	Hyperkalemia	13.6%
122	Hypernatremia	13.6%
123	Hypoglycemia	13.6%
124	Hypokalemia	13.6%
125	Hyponatremia	13.6%
126	Xanthomatosis	13.6%
127	Hypophosphatemia	13.6%
128	Metabolic acidosis	13.6%
129	Dyslipidemias	13.6%
130	Iron Overload	13.6%
131	Xanthoma	13.6%
132	Familial Periodic Paralysis	13.5%
133	Angioedemas, Hereditary	13.4%
134	Polycystic Kidney Diseases	13.3%
135	Williams Syndrome	13.3%
136	Myotonic Dystrophy	13.3%
137	Variegate Porphyria	13.3%
138	Acute intermittent porphyria	13.3%
139	Porphyria Cutanea Tarda	13.3%
140	Marfan Syndrome	13.2%
141	Renal Aminoacidurias	13.2%
142	Fanconi Syndrome	13.2%
143	Pseudohypoaldosteronism	13.2%
144	Liddle Syndrome	13.2%
145	Rubinstein-Taybi Syndrome	12.9%
146	Friedreich Ataxia	12.7%
147	Acute Chest Syndrome	12.6%
148	Tuberous Sclerosis	12.6%
149	Cutis Laxa	12.3%
150	Retinitis Pigmentosa	12.2%
151	Pigmentary retinopathy	12.2%
152	Nutrition Disorders	12.2%
153	Porokeratosis	12.2%
154	Keratoderma, Palmoplantar	12.2%
155	Chronic granulomatous disease	12.1%
156	Welander Distal Myopathy	12%
157	Glycosuria, Renal	12%
158	MELAS Syndrome	11.9%
159	Retinal Dysplasia	11.9%
160	Kallmann Syndrome	11.8%
161	Aniridia	11.8%
162	Nesidioblastosis	11.6%
163	Epidermolysis Bullosa	11.5%
164	Gout	11.5%
165	Hypokalemic periodic paralysis	11.5%
166	Cystinuria	11.4%
167	Classical Lissencephalies and Subcortical Band Heterotopias	11.1%
168	Osteomalacia	11%
169	Diabetic Ketoacidosis	11%
170	Polycystic Kidney, Autosomal Dominant	10.9%
171	Fetal Diseases	10.9%
172	Diabetes Mellitus	10.7%
173	Dehydration	10.3%
174	Duane Retraction Syndrome	10.3%
175	Lipomatosis	10.3%
176	Water Intoxication	10.3%
177	Achlorhydria	10.2%
178	Osteoporosis	10.2%
179	Bone Demineralization, Pathologic	10.2%
180	Post-Traumatic Osteoporosis	10.2%
181	Acidosis, Lactic	10.1%
182	Calciphylaxis	10.1%
183	Hemosiderosis	10.1%
184	Ketosis	10.1%
185	Ketonuria	10.1%
186	Ketoacidosis	10.1%
187	Ketonemia	10.1%
188	Vascular calcification	10.1%
189	Celiac Disease	10.1%
190	Sprue, Tropical	10.1%
191	Steatorrhea	10.1%
192	Sprue	10.1%
193	Peutz-Jeghers Syndrome	10.1%
194	Myotonia Congenita	10.1%
195	Thrombasthenia	10.1%
196	Antithrombin III Deficiency	10.1%
197	Protein C Deficiency	10.1%
198	Afibrinogenemia	10%
199	Dystonia Musculorum Deformans	10%
200	Factor VII Deficiency	10%
201	Factor X Deficiency	10%
202	Factor XII Deficiency	10%
203	Hemophilia A	10%
204	Activated Protein C Resistance	10%
205	Factor II deficiency	10%
206	Factor VIII Deficiency	10%
207	Factor V deficiency	10%
208	Factor XI Deficiency	10%
209	Hypoprothrombinemias	10%
210	Hyperkeratosis, Epidermolytic	10%
211	Mitochondrial Encephalomyopathies	10%
212	Papillon-Lefevre Disease	9.9%
213	Lafora Disease	9.9%
214	Unverricht-Lundborg Syndrome	9.9%
215	Anemia, Diamond-Blackfan	9.9%
216	Arthritis, Gouty	9.9%
217	Charcot-Marie-Tooth Disease	9.4%
218	Abdominal Cramps	9.3%
219	Abnormalities, Drug-Induced	9.3%
220	Amniotic Band Syndrome	9.3%
221	Asphyxia Neonatorum	9.3%
222	Infant, Premature, Diseases	9.3%
223	Situs Inversus	9.3%
224	Infantile Colic	9.3%
225	Pseudoxanthoma Elasticum	9%
226	Multiple Endocrine Neoplasia	8.9%
227	Congenital Hypothyroidism	8.7%
228	Dermatitis, Atopic	8.7%
229	Hypercholesterolemia	8.4%
230	Hyperlipoproteinemias	8.4%
231	Hypertriglyceridemia	8.4%
232	Mitochondrial Myopathies	8.2%
233	Myelinolysis, Central Pontine	8.2%
234	Klinefelter Syndrome	8.2%
235	Glycosuria	8.1%
236	Reye Syndrome	8.1%
237	Hepatic Encephalopathy	8%
238	Xeroderma	8%
239	Mobius Syndrome	8%
240	Meconium Aspiration Syndrome	7.9%
241	HIV Wasting Syndrome	7.6%
242	Kernicterus	7.6%
243	Acidosis, Respiratory	7.6%
244	Adiposis Dolorosa	7.6%
245	Alkalosis, Respiratory	7.6%
246	Behcet Syndrome	7.5%
247	Insulin Resistance	7.5%
248	Osteoporosis, Postmenopausal	7.5%
249	HIV-Associated Lipodystrophy Syndrome	7.4%
250	Anencephaly	7.4%
251	Renal Osteodystrophy	7.3%
252	Renal rickets	7.3%
253	Eye Abnormalities	7.3%
254	Cardiovascular Abnormalities	7.3%
255	Hydrops Fetalis	7.2%
256	Basal Cell Nevus Syndrome	7.2%
257	Multiple Endocrine Neoplasia Type 1	7.1%
258	Skin Abnormalities	7%
259	Lymphatic Abnormalities	7%
260	Congenital Microtia	7%
261	Child Nutrition Disorders	7%
262	Hypervitaminosis A	7%
263	Infant Nutrition Disorders	7%
264	Malnutrition	7%
265	Turner Syndrome	6.9%
266	Anemia, Neonatal	6.9%
267	Persistent Fetal Circulation Syndrome	6.9%
268	Congenital diaphragmatic hernia	6.8%
269	Prune Belly Syndrome	6.8%
270	Twins, Conjoined	6.8%
271	Waardenburg Syndrome	6.8%
272	Umbilical hernia	6.8%
273	Necrobiosis Lipoidica Diabeticorum	6.7%
274	Wernicke Encephalopathy	6.7%
275	Huntington Disease	6.6%
276	Maxillofacial Abnormalities	6.2%
277	Dural Arteriovenous Fistula	6.2%
278	Gestational Diabetes	6.2%
279	Latent Autoimmune Diabetes in Adults	6.2%
280	Dextrocardia	6.1%
281	Diabetes Mellitus, Experimental	6.1%
282	Nephrocalcinosis	6%
283	Tetany	6%
284	Nephroblastoma	6%
285	Cerebral Amyloid Angiopathy	5.9%
286	Urogenital Abnormalities	5.8%
287	Neonatal Abstinence Syndrome	5.6%
288	Fetal Growth Retardation	5.5%
289	Fetal Hypoxia	5.4%
290	Congenital nystagmus	5.4%
291	Fetal Alcohol Spectrum Disorders	5.4%
292	Toxoplasmosis, Congenital	5.4%
293	Syphilis, Congenital	5.4%
294	Adenomatous Polyposis Coli	5.4%
295	Kearns-Sayre syndrome	5.3%
296	Microcephaly	5.2%
297	Macrocephaly	5.2%
298	Anophthalmos	5.2%
299	Anus, Imperforate	5.2%
300	Hydranencephaly	5.2%
301	Microphthalmos	5.2%
302	Neural Tube Defects	5.2%
303	Paralysis, Obstetric	5.2%
304	Retinopathy of Prematurity	5.2%
305	Tethered Cord Syndrome	5.2%
306	Iniencephaly	5.2%
307	Craniorachischisis	5.2%
308	Limb Deformities, Congenital	5.2%
309	Exencephaly	5.2%
310	Septo-Optic Dysplasia	5.2%
311	Craniofacial Abnormalities	5.2%
312	Cortical Dysplasia	5.2%
313	Malformations of Cortical Development	5.2%
314	Anorectal Malformations	5.2%
315	Bronchopulmonary Dysplasia	5%
316	Primary amyloidosis	5%
317	Porencephaly	4.9%
318	Acrocephalosyndactylia	4.8%
319	Craniosynostosis	4.7%
320	Syndactyly	4.7%
321	Brachycephaly	4.7%
322	Scimitar Syndrome	4.7%
323	Deficiency Diseases	4.5%
324	Starvation	4.5%
325	Refeeding Syndrome	4.5%
326	Chorioamnionitis	4.5%
327	Denys-Drash Syndrome	4.5%
328	Amyotrophic Lateral Sclerosis	4.3%
329	Amelia	4.2%
330	Arachnodactyly	4.2%
331	Ectopia Cordis	4.2%
332	Ectromelia	4.2%
333	Hemimelia	4.2%
334	Meningomyelocele	4.2%
335	Noonan Syndrome	4.2%
336	Phocomelia	4.2%
337	Sirenomelia	4.2%
338	Spina Bifida	4.2%
339	Polydactyly	4.2%
340	Brachydactyly	4.2%
341	Plagiocephaly	4.2%
342	Lower Extremity Deformities, Congenital	4.2%
343	Upper Extremity Deformities, Congenital	4.2%
344	Single umbilical artery	4.2%
345	Poland Syndrome	4.2%
346	Blepharophimosis	4.2%
347	Laryngostenosis	4.2%
348	Mouth Abnormalities	4.2%
349	Respiratory Distress Syndrome, Newborn	4.2%
350	Esophageal Atresia	4.1%
351	Intestinal Atresia	4.1%
352	Horseshoe Kidney	4.1%
353	Pectus excavatum	4.1%
354	Cleft Palate	4.1%
355	Frontotemporal dementia	4.1%
356	Klippel-Feil Syndrome	4.1%
357	Gastroschisis	4.1%
358	Synostosis	4.1%
359	Acrodermatitis	4.1%
360	Lymphangiectasis, Intestinal	4.1%
361	Gianotti-Crosti Syndrome	4.1%
362	Jaw Abnormalities	4%
363	Abnormalities, Radiation-Induced	3.8%
364	Dermal Sinus	3.7%
365	Spina Bifida Cystica	3.7%
366	Spina Bifida Occulta	3.7%
367	Lissencephaly	3.7%
368	Polymicrogyria	3.7%
369	Pachygyria	3.7%
370	Schizencephaly	3.7%
371	Periventricular Nodular Heterotopia	3.7%
372	CREST Syndrome	3.7%
373	Micrognathism	3.6%
374	Pierre Robin Syndrome	3.6%
375	Arthrogryposis	3.5%
376	Choanal Atresia	3.5%
377	Tracheobronchomegaly	3.5%
378	Laryngocele	3.5%
379	Choledochal Cyst	3.4%
380	Hermaphroditism	3.4%
381	Disorders of Sex Development	3.4%
382	Cryptorchidism	3.4%
383	Hypospadias	3.4%
384	Central Nervous System Cysts	3.4%
385	Dandy-Walker Syndrome	3.4%
386	Kwashiorkor	3.4%
387	Magnesium Deficiency	3.4%
388	Potassium Deficiency	3.4%
389	Protein Deficiency	3.4%
390	Avitaminosis	3.4%
391	Aortic coarctation	3.4%
392	Cor Triatriatum	3.4%
393	Coronary Vessel Anomalies	3.4%
394	Dental Enamel Hypoplasia	3.4%
395	Patent ductus arteriosus	3.4%
396	Ebstein Anomaly	3.4%
397	Heart Septal Defects	3.4%
398	Hyaline Membrane Disease	3.4%
399	Hypodontia	3.4%
400	Macrostomia	3.4%
401	Meningocele	3.4%
402	Microstomia	3.4%
403	Tetralogy of Fallot	3.4%
404	Transposition of Great Vessels	3.4%
405	Hypoplastic Left Heart Syndrome	3.4%
406	May-Thurner Syndrome	3.4%
407	Encephalocele	3.4%
408	Craniofacial Dysostosis	3.3%
409	Leukomalacia, Periventricular	3.3%
410	POEMS Syndrome	3.3%
411	Wolff-Parkinson-White Syndrome	3.3%
412	Ophthalmia Neonatorum	3.3%
413	Retrognathia	3.2%
414	Aortopulmonary Septal Defect	3%
415	Double Outlet Right Ventricle	3%
416	Endocardial Cushion Defects	3%
417	Laryngomalacia	3%
418	Myocardial bridging	3%
419	Aorticopulmonary Septal Defect	3%
420	Pectus carinatum	2.9%
421	Hyperandrogenism	2.9%
422	Bladder Exstrophy	2.9%
423	Epispadias	2.9%
424	Prognathism	2.9%
425	Multicystic Dysplastic Kidney	2.9%
426	Ascorbic Acid Deficiency	2.8%
427	Long QT Syndrome	2.8%
428	Platybasia	2.8%
429	Vitamin A Deficiency	2.8%
430	Vitamin D Deficiency	2.8%
431	Vitamin E Deficiency	2.8%
432	Marasmus	2.8%
433	Tricuspid Atresia	2.8%
434	Arrhythmogenic Right Ventricular Dysplasia	2.8%
435	Truncus Arteriosus, Persistent	2.8%
436	Gonadal Dysgenesis	2.8%
437	Bronchomalacia	2.8%
438	Goldenhar Syndrome	2.8%
439	Adrenogenital Syndrome	2.8%
440	Tracheomalacia	2.8%
441	Ovotesticular Disorders of Sex Development	2.8%
442	Folic Acid Deficiency	2.5%
443	Pellagra	2.5%
444	Thiamine Deficiency	2.5%
445	Vitamin B 12 Deficiency	2.5%
446	Vitamin B 6 Deficiency	2.5%
447	Pyridoxine Deficiency	2.5%
448	Mandibulofacial Dysostosis	2.5%
449	Romano-Ward Syndrome	2.5%
450	Beriberi	2.4%
451	Talipes	2.3%
452	Congenital clubfoot	2.2%
453	Vertical Talus	2.2%
454	Obesity	2.2%
455	Obesity, Abdominal	2%
456	Arteriovenous fistula	1.9%
457	Anemia, Pernicious	1.8%
458	Vitamin K Deficiency	1.7%
459	Pediatric Obesity	1.6%
460	Scurvy	1.5%
461	Subacute Combined Degeneration	1%

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