MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Shy-Drager Syndrome

(UMLS:C0037019)

Definition:: A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
UMLS ID:: C0037019
MeSH ID:: D012791

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.177.575.550.750|C10.228.140.079.612.700|C10.228.662.550.700|C10.574.625.700

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.514.741

Synonym(s)

Shy-Drager Syndrome

Orthostatic hypotension dysautonomic syndrome

Shy Drager Syndrome

Shy-Drager

Shy-Drager syndrome

dragers shy syndrome

shy drager syndrome

shy dragers syndrome

shy-drager syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fludrocortisone		4740571	CTD
2	Levodopa		963636	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Striatonigral Degeneration	54.9%
2	Lewy Body Disease	33.1%
3	Parkinson Disease	32.6%
4	Parkinsonian Disorders	32.2%
5	Meningoencephalitis	30.5%
6	Encephalomyelitis	29.8%
7	Progressive supranuclear palsy	28.9%
8	Dystonia Musculorum Deformans	28.1%
9	Basal Ganglia Cerebrovascular Disease	27.3%
10	Prion Diseases	26.5%
11	Meige Syndrome	26.5%
12	Ocular Motility Disorders	25.7%
13	Cyclophoria	25.7%
14	Subacute Combined Degeneration	25.4%
15	Huntington Disease	25.3%
16	Pneumocephalus	25.3%
17	Motor Neuron Disease	25.3%
18	Amyotrophic Lateral Sclerosis	25.3%
19	Dementia, Vascular	24.8%
20	Cerebrovascular Disorders	24.3%
21	Cerebrovascular Insufficiency	24.3%
22	Stiff-Person Syndrome	23.9%
23	Dandy-Walker Syndrome	23.2%
24	Spinal Muscular Atrophy	23.2%
25	Progressive Muscular Atrophy	23.2%
26	Asterixis	23.2%
27	Ballismus	23.2%
28	Subdural Effusion	22.8%
29	Epidural Abscess	22.7%
30	Hypotension, Orthostatic	22.6%
31	Post-Exercise Hypotension	22.6%
32	Neuroleptic Malignant Syndrome	22.3%
33	Myelitis	22%
34	Vasculitis, Central Nervous System	21.8%
35	Meningitis	21.8%
36	Pachymeningitis	21.8%
37	Spinal Cord Diseases	21.8%
38	Hepatolenticular Degeneration	21.5%
39	Lupus Vasculitis, Central Nervous System	21.1%
40	Brain Abscess	20.9%
41	MPTP Poisoning	20.6%
42	Cranial nerve diseases	20.6%
43	Demyelinating Diseases	20.6%
44	Demyelination	20.6%
45	Neuromuscular Diseases	20.6%
46	Chronobiology Disorders	20.6%
47	Autonomic Dysreflexia	20.3%
48	Complex Regional Pain Syndromes	20.3%
49	Leukomalacia, Periventricular	20%
50	Vascular Headaches	19.9%
51	Basal Ganglia Hemorrhage	19.9%
52	Marchiafava-Bignami Disease	19.8%
53	Spinal Cord Vascular Diseases	19.6%
54	Essential Tremor	19.3%
55	Familial Tremor	19.3%
56	Writer's Cramp	19.3%
57	Ophthalmoplegic Migraine	19.3%
58	Myelitis, Transverse	19.2%
59	Central Nervous System Infection	19.2%
60	Restless Legs Syndrome	19.2%
61	Brain Injuries	18.9%
62	Brain Neoplasms	18.8%
63	Poliomyelitis	18.8%
64	Limbic Encephalitis	18.8%
65	Spinal Cord Injuries	18.7%
66	Hypoxia-Ischemia, Brain	18.6%
67	Akathisia, Drug-Induced	18.6%
68	Epilepsy, Post-Traumatic	18.6%
69	Leukoencephalopathy, Progressive Multifocal	18.3%
70	Polyradiculoneuropathy	18.3%
71	Polyradiculoneuritis	18.3%
72	Moyamoya Disease	18.3%
73	Akinetic Mutism	18.3%
74	Anoxic Encephalopathy	18.3%
75	Brain Damage, Chronic	18.3%
76	Cerebellar Diseases	18.3%
77	Encephalitis	18.3%
78	Encephalomalacia	18.3%
79	Epilepsy	18.3%
80	Hydrocephalus	18.3%
81	Congenital Hydrocephalus	18.3%
82	Hypothalamic Diseases	18.3%
83	Thalamic Diseases	18.3%
84	Intracranial Hypertension	18.3%
85	Aura	18.3%
86	Leukoencephalopathy	18.3%
87	Neuroaxonal Dystrophies	18.3%
88	Headache Disorders	18.3%
89	Intracranial Hypotension	18.3%
90	Brain Edema	18.3%
91	Brain Hypoxia	18.3%
92	Aqueductal Stenosis	18.3%
93	Carotid Artery Injuries	18.2%
94	Multiple System Atrophy	18.2%
95	Trauma, Nervous System	18.1%
96	Tauopathies	17.9%
97	Opsoclonus-Myoclonus Syndrome	17.9%
98	Nervous System Neoplasms	17.8%
99	Neurologic Manifestations	17.8%
100	Neurotoxicity Syndromes	17.8%
101	Brain Infarction	17.6%
102	Leukoencephalitis, Acute Hemorrhagic	17.4%
103	Myelinolysis, Central Pontine	17.3%
104	Intracranial Embolism and Thrombosis	17.3%
105	Presenile dementia	17.2%
106	Senile dementia	17.2%
107	Cerebral Ventriculitis	17.2%
108	Posterior Leukoencephalopathy Syndrome	17.1%
109	Posterior reversible encephalopathy syndrome	17.1%
110	Dyskinesia, Drug-Induced	17%
111	Chronic Fatigue Syndrome	16.7%
112	Putaminal Hemorrhage	16.4%
113	Miller Fisher Syndrome	16.3%
114	Infarction, Middle Cerebral Artery	16.1%
115	Infarction, Anterior Cerebral Artery	16.1%
116	Infarction, Posterior Cerebral Artery	16.1%
117	Lambert-Eaton Myasthenic Syndrome	16.1%
118	Meningitis, Bacterial	16%
119	Meningitis, Fungal	16%
120	Brain Death	15.9%
121	Brain Diseases, Metabolic	15.8%
122	Dementia	15.8%
123	Sleep Wake Disorders	15.8%
124	Brain Hemorrhage, Traumatic	15.7%
125	Carotid Artery Diseases	15.6%
126	Brain Ischemia	15.6%
127	Cerebrovascular accident	15.6%
128	Vasospasm, Intracranial	15.6%
129	Intracranial Arterial Diseases	15.6%
130	Cerebellar Neoplasms	15.6%
131	Progressive bulbar palsy	15.5%
132	Bulbar palsy	15.5%
133	Subarachnoid Hemorrhage, Traumatic	15.4%
134	Carotid Artery, Internal, Dissection	15.4%
135	Lafora Disease	15.3%
136	Unverricht-Lundborg Syndrome	15.3%
137	Amblyopia	15.3%
138	Paraneoplastic Cerebellar Degeneration	15.2%
139	Canavan Disease	15.2%
140	Alexander Disease	15.2%
141	Creutzfeldt-Jakob disease	15.1%
142	Vertebral Artery Dissection	15%
143	Giant Cell Arteritis	14.9%
144	Temporal Arteritis	14.9%
145	Scrapie	14.8%
146	Carotid Stenosis	14.8%
147	Intracranial Aneurysm	14.8%
148	Friedreich Ataxia	14.8%
149	Spinal Cord Neoplasms	14.7%
150	Carotid Artery Thrombosis	14.7%
151	Encephalomyelitis, Acute Disseminated	14.7%
152	Chorea	14.7%
153	Pituitary Apoplexy	14.5%
154	Causalgia	14.5%
155	Guillain-Barre Syndrome	14.4%
156	Sweating, Gustatory	14.4%
157	Auriculotemporal Syndrome	14.4%
158	Brain Diseases	14.3%
159	Myoclonic Epilepsy	14.3%
160	Epilepsy, Temporal Lobe	14.3%
161	Epilepsy, Rolandic	14.3%
162	Benign Rolandic Epilepsy	14.3%
163	Cerebral Infarction	14.3%
164	Brain Stem Infarctions	14.3%
165	Orthostatic intolerance	14.3%
166	Horner Syndrome	14.2%
167	Ataxia Telangiectasia	14%
168	Peripheral Nerve Injuries	13.8%
169	Myasthenia Gravis	13.7%
170	Paraneoplastic Encephalomyelitis	13.6%
171	Intracranial Arteriosclerosis	13.6%
172	Cerebral Atherosclerosis	13.6%
173	Cerebral Arteriosclerosis	13.6%
174	Movement Disorders	13.5%
175	Sturge-Weber Syndrome	13.4%
176	Toxoplasmosis, Cerebral	13.1%
177	Amnesia, Transient Global	13%
178	Torticollis	13%
179	Hand-Arm Vibration Syndrome	13%
180	Cerebral Thrombosis	12.9%
181	Intracranial Embolism	12.9%
182	Intracranial Thrombosis	12.9%
183	Spinal Cord Ischemia	12.8%
184	Arachnoiditis	12.8%
185	Aseptic Meningitis	12.8%
186	Syringomyelia	12.8%
187	Pneumorrhachis	12.8%
188	Optic Neuropathy, Ischemic	12.7%
189	Anterior Ischemic Optic Neuropathy	12.7%
190	Neuromyelitis Optica	12.7%
191	Lateral Medullary Syndrome	12.6%
192	Reflex Sympathetic Dystrophy	12.6%
193	Thoracic Outlet Syndrome	12.5%
194	Sleep Disorders, Circadian Rhythm	12.4%
195	Tuberculosis, Meningeal	12.4%
196	Pituitary Adenoma	12.3%
197	Pituitary Neoplasms	12.3%
198	Brain Injuries, Diffuse	12.2%
199	Traumatic Brain Injury	12.2%
200	Olfactory Nerve Injuries	12.2%
201	Cerebellar Ataxia	12.1%
202	Supratentorial Neoplasms	12.1%
203	Botulism	12.1%
204	Central Nervous System Cysts	12.1%
205	Tuberous Sclerosis	11.8%
206	Cerebral Palsy	11.7%
207	Epilepsies, Partial	11.7%
208	Epilepsy, Generalized	11.7%
209	Pseudotumor Cerebri	11.7%
210	Hypertensive Encephalopathy	11.7%
211	Simple Partial Seizures	11.7%
212	Epilepsy, Reflex	11.7%
213	Headache Disorders, Primary	11.7%
214	Headache Disorders, Secondary	11.7%
215	Medication overuse headache	11.7%
216	Central Cord Syndrome	11.5%
217	Juvenile Myoclonic Epilepsy	11.5%
218	Myoclonic Epilepsies, Progressive	11.5%
219	Myocardial Ischemia	11.5%
220	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	11.4%
221	Cerebral Arterial Diseases	11.3%
222	Vertebrobasilar Insufficiency	11.3%
223	Basilar Artery Stenosis	11.3%
224	Vertebral Artery Stenosis	11.3%
225	Intracranial Hemorrhage, Hypertensive	11.3%
226	Transient Cerebral Ischemia	11.3%
227	Persistent Vegetative State	11.3%
228	Vagus Nerve Disorder	11.3%
229	Glossopharyngeal Neuralgia	11.3%
230	Abducens Nerve Diseases	11.3%
231	Heavy Metal Poisoning, Nervous System	11.3%
232	Neuromuscular Junction Diseases	11.3%
233	Trochlear Nerve Diseases	11.3%
234	Peripheral Nervous System Diseases	11.3%
235	Aortic Aneurysm	11.2%
236	Aortitis	11.2%
237	Leriche Syndrome	11.2%
238	Periphlebitis	11.2%
239	Phlebitis	11.2%
240	Thromboangiitis Obliterans	11.2%
241	Central Nervous System Fungal Infections	11.1%
242	Conus Medullaris Syndrome	11.1%
243	Postural Orthostatic Tachycardia Syndrome	11.1%
244	Facial Nerve Injuries	11%
245	Charcot-Marie-Tooth Disease	10.9%
246	Frontotemporal dementia	10.8%
247	Sinus Thrombosis, Intracranial	10.8%
248	Shy-Drager Syndrome	10.7%
249	MELAS Syndrome	10.7%
250	Retinal Vein Occlusion	10.6%
251	Myotonia Congenita	10.6%
252	Myocardial Reperfusion Injury	10.5%
253	Tardive Dyskinesia	10.5%
254	Thrombophlebitis	10.3%
255	Pituitary Diseases	10.3%
256	Multiple Sclerosis	10.2%
257	Kluver-Bucy Syndrome	10%
258	Myopathy	10%
259	Optic Neuropathy	10%
260	Myasthenia Gravis, Autoimmune, Experimental	9.9%
261	Subarachnoid Hemorrhage	9.9%
262	Cerebral Hemorrhage	9.9%
263	Aneurysm	9.9%
264	Angiomatosis	9.9%
265	Aortic Diseases	9.9%
266	Arterial Occlusive Diseases	9.9%
267	Hyperemia	9.9%
268	Superior Vena Cava Syndrome	9.9%
269	Telangiectasis	9.9%
270	Vasculitis	9.9%
271	Venous Insufficiency	9.9%
272	Peripheral Vascular Diseases	9.9%
273	Embolism and Thrombosis	9.9%
274	Angiodysplasia	9.9%
275	Capillary Leak Syndrome	9.9%
276	Prehypertension	9.9%
277	Refsum Disease	9.9%
278	Malignant Atrophic Papulosis	9.9%
279	Aortic Rupture	9.8%
280	Shwartzman Phenomenon	9.8%
281	Central Nervous System Bacterial Infections	9.8%
282	Postphlebitic Syndrome	9.8%
283	Nocturnal Myoclonus Syndrome	9.8%
284	Mitochondrial Encephalomyopathies	9.8%
285	Facial Nerve Diseases	9.8%
286	Craniocerebral Trauma	9.8%
287	Parasomnia	9.8%
288	Dyssomnias	9.8%
289	Coronary Aneurysm	9.8%
290	Meningitis, Cryptococcal	9.7%
291	Meningitis, Listeria	9.7%
292	Subacute Sclerosing Panencephalitis	9.7%
293	Meningitis, Haemophilus	9.7%
294	Meningitis, Pneumococcal	9.7%
295	Vestibulocochlear Nerve Diseases	9.7%
296	Decerebrate State	9.7%
297	Hemiparesis	9.7%
298	Hydranencephaly	9.7%
299	Meningism	9.7%
300	Neural Tube Defects	9.7%
301	Paresis	9.7%
302	Seizures	9.7%
303	Sensation Disorders	9.7%
304	Tethered Cord Syndrome	9.7%
305	Central Nervous System Neoplasms	9.7%
306	Complex partial seizures	9.7%
307	Iniencephaly	9.7%
308	Craniorachischisis	9.7%
309	Exencephaly	9.7%
310	Monoparesis	9.7%
311	Septo-Optic Dysplasia	9.7%
312	Cortical Dysplasia	9.7%
313	Neurogenic Inflammation	9.7%
314	Gait Disorders, Neurologic	9.7%
315	Neuromuscular Manifestations	9.7%
316	Malformations of Cortical Development	9.7%
317	Cavernous Sinus Thrombosis	9.7%
318	Sagittal Sinus Thrombosis	9.7%
319	Myotonic Dystrophy	9.7%
320	Adrenoleukodystrophy	9.6%
321	Jet Lag Syndrome	9.6%
322	Anterior Spinal Artery Syndrome	9.5%
323	Subclavian Steal Syndrome	9.2%
324	Ophthalmoplegia	9.2%
325	External Ophthalmoplegia	9.2%
326	Dural Arteriovenous Fistula	9%
327	Brain Concussion	9%
328	Arteriovenous fistula	8.9%
329	Auditory Perceptual Disorders	8.9%
330	Diffuse Axonal Injury	8.9%
331	Brain Stem Neoplasms	8.9%
332	Reye Syndrome	8.8%
333	Vascular System Injuries	8.8%
334	Hepatic Encephalopathy	8.8%
335	Basal Ganglia Diseases	8.7%
336	Blue Toe Syndrome	8.7%
337	Pupil Disorders	8.7%
338	Neurobehavioral Manifestations	8.7%
339	Alice in Wonderland Syndrome	8.7%
340	Compartment syndromes	8.6%
341	Hepatic Veno-Occlusive Disease	8.6%
342	Peliosis Hepatis	8.6%
343	Varicocele	8.6%
344	Dysautonomia	8.5%
345	Acrodynia	8.5%
346	Coronary Thrombosis	8.5%
347	Coronary Artery Disease	8.5%
348	Diabetic Angiopathies	8.5%
349	Reperfusion Injury	8.5%
350	Splenic Infarction	8.5%
351	Vascular Neoplasms	8.5%
352	Vasoplegia	8.5%
353	Uveomeningoencephalitic Syndrome	8.5%
354	Hemorrhoids	8.5%
355	Vertigo	8.5%
356	Alcohol-Induced Disorders, Nervous System	8.5%
357	Post-Traumatic Headache	8.4%
358	Tension Headache	8.4%
359	Epilepsy, Complex Partial	8.4%
360	Migraine Disorders	8.4%
361	Abdominal Migraine	8.4%
362	Status Migrainosus	8.4%
363	Cervicogenic Headache	8.4%
364	Hematoma, Subdural	8.4%
365	Hematoma, Epidural, Cranial	8.4%
366	Aortic Aneurysm, Abdominal	8.4%
367	Aortic Aneurysm, Thoracic	8.4%
368	Vocal Cord Paralysis	8.3%
369	Cerebral Amyloid Angiopathy	8.1%
370	Brain Contusion	7.9%
371	Brachial Plexus Neuritis	7.9%
372	Neuralgic Amyotrophy	7.9%
373	Amyloid Neuropathies, Familial	7.8%
374	Brain Diseases, Metabolic, Inborn	7.8%
375	Alstrom Syndrome	7.8%
376	Voice Disorders	7.7%
377	Voice Disturbance	7.7%
378	Cerebrospinal Fluid Otorrhea	7.6%
379	Cerebrospinal Fluid Rhinorrhea	7.6%
380	Neuritis, Autoimmune, Experimental	7.6%
381	Gait Ataxia	7.6%
382	Smith-Magenis syndrome	7.6%
383	Mesenteric vascular insufficiency	7.5%
384	Coronary heart disease	7.5%
385	Myocardial Infarction	7.5%
386	Acute Coronary Syndrome	7.5%
387	West Nile Fever	7.5%
388	Alcohol Withdrawal Seizures	7.4%
389	Angioedema	7.4%
390	Colitis, Ischemic	7.4%
391	Coma, Post-Head Injury	7.3%
392	Polyarteritis Nodosa	7.3%
393	Takayasu Arteritis	7.3%
394	Empty Sella Syndrome	7.3%
395	Hyperpituitarism	7.3%
396	Hypopituitarism	7.3%
397	Hypophysitis	7.3%
398	Choroid Plexus Papilloma	7.2%
399	Tuberculosis, Central Nervous System	7.2%
400	Hematoma, Subdural, Intracranial	7.1%
401	Hematoma, Subdural, Chronic	7.1%
402	Hematoma, Subdural, Acute	7.1%
403	Wernicke Encephalopathy	7%
404	AIDS Dementia Complex	7%
405	Tarsal Tunnel Syndrome	6.9%
406	Cauda Equina Syndrome	6.9%
407	Multiple Sclerosis, Chronic Progressive	6.9%
408	Multiple Sclerosis, Relapsing-Remitting	6.9%
409	Optic Nerve Glioma	6.9%
410	Akathisia	6.8%
411	Restlessness	6.8%
412	Psychomotor Agitation	6.8%
413	Neuritis	6.8%
414	Polyneuritis	6.8%
415	Radiculitis	6.8%
416	Polyneuropathy	6.8%
417	Mononeuritis	6.8%
418	Mononeuropathies	6.8%
419	Brachial Plexus Neuropathies	6.8%
420	Radiculopathy	6.8%
421	Mononeuropathy Multiplex	6.8%
422	Nerve Root Compression	6.8%
423	Cluster Headache	6.7%
424	Migraine with Aura	6.7%
425	Familial Hemiplegic Migraine	6.7%
426	Chronic Paroxysmal Hemicrania	6.7%
427	SUNCT Syndrome	6.7%
428	Paroxysmal Hemicrania	6.7%
429	Reflex, Abnormal	6.7%
430	Hyporeflexia	6.7%
431	Hyperreflexia	6.7%
432	Scimitar Syndrome	6.7%
433	Fabry Disease	6.7%
434	Neuronal Ceroid-Lipofuscinoses	6.7%
435	Kounis Syndrome	6.6%
436	May-Thurner Syndrome	6.5%
437	Aneurysm, Dissecting	6.5%
438	Arteriosclerosis	6.5%
439	Arteritis	6.5%
440	Embolism	6.5%
441	Erythromelalgia	6.5%
442	Fibromuscular Dysplasia	6.5%
443	Malignant Hypertension	6.5%
444	Raynaud Disease	6.5%
445	Thromboembolism	6.5%
446	Thrombosis	6.5%
447	Essential Hypertension	6.5%
448	Aneurysm, Ruptured	6.5%
449	Iliac Aneurysm	6.5%
450	Pulmonary artery stenosis	6.5%
451	White Coat Hypertension	6.5%
452	Systemic Vasculitis	6.5%
453	Embolus	6.5%
454	Angina Pectoris	6.5%
455	Lemierre Syndrome	6.5%
456	Kernicterus	6.5%
457	Neuroaspergillosis	6.3%
458	CREST Syndrome	6.2%
459	Embolism, Amniotic Fluid	6.2%
460	Gait Apraxia	6.2%
461	Cockayne Syndrome	6.1%
462	Carpal Tunnel Syndrome	6.1%
463	neurofibroma	6.1%
464	Sciatica	6.1%
465	Myositis	5.9%
466	Optic Atrophy	5.9%
467	Optic Neuritis	5.9%
468	Papilledema	5.9%
469	Strabismus	5.9%
470	Tolosa-Hunt Syndrome	5.9%
471	Isaacs syndrome	5.9%
472	Arsenic Poisoning	5.9%
473	Myotonic Disorders	5.9%
474	Myasthenic Syndromes, Congenital	5.9%
475	Diabetic Neuropathies	5.9%
476	Facial Injuries	5.9%
477	Facial Neuralgia	5.9%
478	Diabetic Amyotrophy	5.9%
479	Diabetic Autonomic Neuropathy	5.9%
480	Sleep Talking	5.9%
481	Manganese Poisoning	5.9%
482	Sleep Disorders, Intrinsic	5.9%
483	Anosmia	5.8%
484	Ataxia	5.8%
485	Athetosis	5.8%
486	Catalepsy	5.8%
487	Dystonia	5.8%
488	Hemiplegia	5.8%
489	Locked-In Syndrome	5.8%
490	Meningeal Neoplasms	5.8%
491	Meningomyelocele	5.8%
492	Muscle Hypertonia	5.8%
493	Muscle hypotonia	5.8%
494	Myoclonus	5.8%
495	Myotonia	5.8%
496	Neuralgia	5.8%
497	Paraplegia	5.8%
498	Pseudobulbar Palsy	5.8%
499	Quadriplegia	5.8%
500	Spasm	5.8%
501	Spastic Paraplegia	5.8%
502	Status Epilepticus	5.8%
503	Taste Disorders	5.8%
504	Tremor	5.8%
505	Spina Bifida	5.8%
506	Monoplegia	5.8%
507	Hypokinesia	5.8%
508	Paraparesis	5.8%
509	Bradykinesia	5.8%
510	Waxy flexibility	5.8%
511	Action Tremor	5.8%
512	Resting Tremor	5.8%
513	Dysosmia	5.8%
514	Quadriparesis	5.8%
515	Mercury Poisoning, Nervous System	5.8%
516	Olfaction Disorders	5.8%
517	Myokymia	5.8%
518	Lead Poisoning, Nervous System	5.8%
519	Vestibular Neuronitis	5.8%
520	Somatosensory Disorders	5.8%
521	Neuropathic pain	5.8%
522	Hyperkinesia	5.8%
523	Intention tremor	5.8%
524	Pseudorabies	5.8%
525	Acoustic Neuroma	5.8%
526	Hyperprolactinemia	5.8%
527	Pick Disease of the Brain	5.8%
528	Optic Atrophy, Hereditary, Leber	5.7%
529	Retinal Artery Occlusion	5.7%
530	Retinal Vasculitis	5.7%
531	Hypertensive Retinopathy	5.7%
532	Heart Diseases	5.6%
533	Anterior Compartment Syndrome	5.6%
534	Vasculitis, Leukocytoclastic, Cutaneous	5.6%
535	Gastric Antral Vascular Ectasia	5.6%
536	Abdominal Compartment Syndrome	5.6%
537	Varicose Ulcer	5.6%
538	Primary Graft Dysfunction	5.6%
539	Neurosyphilis	5.6%
540	Coronary Occlusion	5.6%
541	Microvascular Angina	5.6%
542	Coronary Stenosis	5.6%
543	ST segment elevation myocardial infarction	5.6%
544	Cubital Tunnel Syndrome	5.3%
545	Vision Disorders	5.2%
546	Metamorphopsia	5.2%
547	Visual Impairment	5.2%
548	Fibromyalgia	5.2%
549	Medial Tibial Stress Syndrome	5.2%
550	Facial Hemiatrophy	5.2%
551	Melkersson-Rosenthal Syndrome	5.2%
552	Mitochondrial Myopathies	5.2%
553	Anisocoria	5.2%
554	Confusion	5.2%
555	Facial paralysis	5.2%
556	Lethargy	5.2%
557	Memory Disorders	5.2%
558	Muscle Cramp	5.2%
559	Perceptual Disorders	5.2%
560	Psychomotor Disorders	5.2%
561	Tonic Pupil	5.2%
562	Eosinophilia-Myalgia Syndrome	5.2%
563	Anhedonia	5.2%
564	Disorientation	5.2%
565	Facial Paresis	5.2%
566	Memory Loss	5.2%
567	Hemisensory Neglect	5.2%
568	Dysacusis	5.2%
569	Sleep Bruxism	5.1%
570	Anencephaly	5.1%
571	Meningocele	5.1%
572	Muscular Atrophy	5.1%
573	Respiratory Paralysis	5.1%
574	Encephalocele	5.1%
575	Acromegaly	5.1%
576	Tetany	5.1%
577	Kearns-Sayre syndrome	5.1%
578	Lyme Neuroborreliosis	5%
579	Mesenteric Vascular Occlusion	5%
580	Mucocutaneous Lymph Node Syndrome	5%
581	Diabetic Retinopathy	4.9%
582	Livedo Reticularis	4.9%
583	Renal hypertension	4.9%
584	Renal Artery Obstruction	4.9%
585	Renal Artery Stenosis	4.9%
586	Hemangioma, Cavernous	4.9%
587	Shock, Cardiogenic	4.9%
588	Arteriosclerosis Obliterans	4.9%
589	Atherosclerosis	4.9%
590	Air Embolism	4.9%
591	Endarteritis	4.9%
592	Venous Thrombosis	4.9%
593	Deep Vein Thrombosis	4.9%
594	Venous Thromboembolism	4.9%
595	Scurvy	4.9%
596	Pregnancy Complications, Cardiovascular	4.9%
597	Cardiovascular Abnormalities	4.9%
598	Angina, Unstable	4.9%
599	Waterhouse-Friderichsen Syndrome	4.8%
600	Classical Lissencephalies and Subcortical Band Heterotopias	4.8%
601	Menkes Kinky Hair Syndrome	4.7%
602	Toxoplasmosis, Congenital	4.7%
603	Malaria, Cerebral	4.7%
604	Neurocysticercosis	4.7%
605	Duane Retraction Syndrome	4.6%
606	Consciousness Disorders	4.6%
607	Mental Retardation	4.6%
608	Muscle Weakness	4.6%
609	Depressed Level of Consciousness	4.6%
610	Mental deficiency	4.6%
611	Intellectual Disability	4.6%
612	Coronary Restenosis	4.6%
613	Sciatic Neuropathy	4.6%
614	Ulnar Neuropathies	4.6%
615	Lesion of Sciatic Nerve	4.6%
616	Ulnar Neuritis	4.6%
617	Radial nerve compression	4.6%
618	Radial Tunnel Syndrome	4.6%
619	Peroneal Neuropathies	4.6%
620	Radial Neuropathy	4.6%
621	Median Neuropathy	4.6%
622	Sciatic Nerve Palsy	4.6%
623	Femoral Neuropathy	4.6%
624	Tibial Neuropathy	4.6%
625	Ulnar Nerve Palsy	4.6%
626	Radial nerve palsy	4.6%
627	Mobius Syndrome	4.6%
628	Bell Palsy	4.6%
629	Catatonia	4.6%
630	Herpes Zoster Oticus	4.6%
631	Familial Periodic Paralysis	4.6%
632	Galactosemias	4.6%
633	Urea Cycle Disorders, Inborn	4.6%
634	Tyrosinemias	4.6%
635	Aphonia	4.6%
636	Sleep Deprivation	4.6%
637	Dysphonia	4.6%
638	Ischemic contracture	4.4%
639	Angioedemas, Hereditary	4.4%
640	Tricuspid Atresia	4.4%
641	Arrhythmogenic Right Ventricular Dysplasia	4.4%
642	Cryoglobulinemia	4.4%
643	Diabetic Foot	4.3%
644	Intermittent Claudication	4.2%
645	Pulmonary Embolism	4.2%
646	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	4.2%
647	Homocystinuria	4.2%
648	No-Reflow Phenomenon	4.2%
649	Alexia	4.2%
650	Dyslexia	4.2%
651	Leigh Disease	4.2%
652	Myalgia	4.1%
653	Prolactinoma	4.1%
654	Growth Hormone-Secreting Pituitary Adenoma	4.1%
655	Angina Pectoris, Variant	4%
656	Williams Syndrome	4%
657	Esotropia	4%
658	Exotropia	4%
659	Sleep Apnea Syndromes	4%
660	Polymyositis	4%
661	Nelson Syndrome	3.9%
662	Disorders of Excessive Somnolence	3.9%
663	Sleep Initiation and Maintenance Disorders	3.9%
664	Night Terrors	3.9%
665	Somnambulism	3.9%
666	Trigeminal Nerve Disorder	3.9%
667	Transient Insomnia	3.9%
668	Sleep Paralysis	3.9%
669	Chronic Insomnia	3.9%
670	REM Sleep Behavior Disorder	3.9%
671	Hypersomnia	3.9%
672	Dermal Sinus	3.9%
673	Dysgeusia	3.9%
674	Formication	3.9%
675	Hyperalgesia	3.9%
676	Hyperesthesia	3.9%
677	Hypesthesia	3.9%
678	Language Disorders	3.9%
679	Numbness	3.9%
680	Paresthesia	3.9%
681	Paraparesis, Spastic	3.9%
682	Spina Bifida Cystica	3.9%
683	Trismus	3.9%
684	Spina Bifida Occulta	3.9%
685	Epilepsia Partialis Continua	3.9%
686	Hypogeusia	3.9%
687	Meningeal Carcinomatosis	3.9%
688	Brown-Sequard Syndrome	3.9%
689	Lissencephaly	3.9%
690	Polymicrogyria	3.9%
691	Pachygyria	3.9%
692	Schizencephaly	3.9%
693	Lockjaw	3.9%
694	Allodynia	3.9%
695	Lead Poisoning, Nervous System, Childhood	3.9%
696	Lead Poisoning, Nervous System, Adult	3.9%
697	Periventricular Nodular Heterotopia	3.9%
698	Ageusia	3.9%
699	Purpura, Hyperglobulinemic	3.9%
700	Neurofibrosarcoma	3.9%
701	Aicardi's syndrome	3.8%
702	Hoarseness	3.8%
703	Aortic Valve Stenosis	3.7%
704	Cardiomyopathy, Dilated	3.7%
705	Pulmonary Valve Stenosis	3.7%
706	Alcohol Withdrawal Delirium	3.7%
707	Bacterial Endocarditis	3.7%
708	Hypertension, Renovascular	3.6%
709	Hereditary Angioedema Type III	3.6%
710	Hereditary Angioedema Types I and II	3.6%
711	Behcet Syndrome	3.6%
712	Waldenstrom Macroglobulinemia	3.6%
713	Multiple Myeloma	3.6%
714	Eye Injuries	3.5%
715	Hepatic Vein Thrombosis	3.5%
716	Budd-Chiari Syndrome	3.5%
717	Polyradiculopathy	3.5%
718	Muscular Dystrophy	3.5%
719	Congenital nystagmus	3.5%
720	Orbital Myositis	3.5%
721	Pulmonary Infarction	3.5%
722	Diplopia	3.5%
723	Muscle Rigidity	3.5%
724	Muscle Spasticity	3.5%
725	Scotoma	3.5%
726	Photophobia	3.5%
727	Cogwheel Rigidity	3.5%
728	Hemifacial Spasm	3.5%
729	Amaurosis	3.5%
730	Blindness	3.5%
731	Nuchal Rigidity	3.5%
732	Pyomyositis	3.5%
733	Agnosia	3.5%
734	Apraxias	3.5%
735	Hallucinations	3.5%
736	Hemianopsia	3.5%
737	Hyperacusis	3.5%
738	Tinnitus	3.5%
739	Visual Agnosia	3.5%
740	Anosognosia	3.5%
741	Wernicke-Korsakoff Syndrome	3.5%
742	Phonophobia	3.5%
743	Hearing Loss	3.5%
744	Sarcopenia	3.4%
745	Holoprosencephaly	3.4%
746	Zellweger Syndrome	3.4%
747	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.4%
748	Pseudoxanthoma Elasticum	3.3%
749	Cardiac Tamponade	3.3%
750	Endocarditis	3.3%
751	Cardiac Arrest	3.3%
752	Heart failure	3.3%
753	Pericardial effusion	3.3%
754	Pericarditis	3.3%
755	Pneumopericardium	3.3%
756	Cor pulmonale	3.3%
757	Ventricular Outflow Obstruction	3.3%
758	Ventricular Dysfunction	3.3%
759	Cardiomyopathies	3.3%
760	Pleuropericarditis	3.3%
761	Heart Block	3.3%
762	Tachycardia	3.3%
763	Tachyarrhythmia	3.3%
764	Aortic coarctation	3.3%
765	Cor Triatriatum	3.3%
766	Coronary Vessel Anomalies	3.3%
767	Patent ductus arteriosus	3.3%
768	Ebstein Anomaly	3.3%
769	Heart Septal Defects	3.3%
770	Tetralogy of Fallot	3.3%
771	Transposition of Great Vessels	3.3%
772	Hypoplastic Left Heart Syndrome	3.3%
773	Amnesia	3.1%
774	Delirium	3.1%
775	Dissociative Amnesia	3.1%
776	Color blindness	3.1%
777	Global Amnesia	3.1%
778	Cri-du-Chat Syndrome	3.1%
779	Down Syndrome	3.1%
780	Trisomy 21	3.1%
781	POEMS Syndrome	3.1%
782	Glycogen storage disease type II	3.1%
783	Meningioma	3.1%
784	Microcephaly	3.1%
785	Macrocephaly	3.1%
786	Hypokalemic periodic paralysis	3.1%
787	Granulomatosis with polyangiitis	3.1%
788	Porencephaly	3.1%
789	Hypertrophic Cardiomyopathy	3%
790	Hypertrophic obstructive cardiomyopathy	3%
791	Sleep Apnea, Obstructive	3%
792	Sleep Apnea, Central	3%
793	Narcolepsy	3%
794	Trigeminal Neuralgia	3%
795	Kleine-Levin Syndrome	3%
796	Agraphia	3%
797	Anomia	3%
798	Cluttering	3%
799	Language Development Disorders	3%
800	Speech Disorders	3%
801	Syncope	3%
802	Stupor	3%
803	Dysgraphia	3%
804	Presyncope	3%
805	Dyslalia	3%
806	Rheumatoid Vasculitis	2.9%
807	Sick Sinus Syndrome	2.9%
808	Dextrocardia	2.9%
809	Long QT Syndrome	2.9%
810	Cardiac Output, High	2.9%
811	Myocardial Stunning	2.9%
812	Low Cardiac Output Syndrome	2.9%
813	Cardiomegaly	2.8%
814	Postpericardiotomy Syndrome	2.8%
815	Cardiac Hypertrophy	2.8%
816	Rheumatic Heart Disease	2.8%
817	Supravalvular aortic stenosis	2.8%
818	Lown-Ganong-Levine Syndrome	2.8%
819	Prader-Willi Syndrome	2.8%
820	Phantom pain	2.8%
821	Phantom Limb Pain	2.8%
822	Eye Burns	2.7%
823	Welander Distal Myopathy	2.6%
824	Amaurosis Fugax	2.6%
825	Blindness, Cortical	2.6%
826	Dyscalculia	2.6%
827	Rett Syndrome	2.6%
828	Deafness	2.6%
829	Hearing Loss, Sudden	2.6%
830	Gerstmann Syndrome	2.6%
831	Hearing Loss, Bilateral	2.6%
832	Hearing Loss, High-Frequency	2.6%
833	Hearing Loss, Mixed Conductive-Sensorineural	2.6%
834	Prosopagnosia	2.6%
835	Apraxia, Ideomotor	2.6%
836	Charles Bonnet Syndrome	2.6%
837	Hearing Loss, Unilateral	2.6%
838	Complete Hearing Loss	2.6%
839	Alien Hand Syndrome	2.6%
840	Deaf Mutism	2.6%
841	Cataplexy	2.5%
842	Aphasia	2.5%
843	Articulation Disorders	2.5%
844	Echolalia	2.5%
845	Stuttering	2.5%
846	Dysphasia	2.5%
847	Gaucher Disease	2.5%
848	Adams-Stokes Syndrome	2.4%
849	Atrioventricular Block	2.4%
850	Bundle-Branch Block	2.4%
851	Atrial Premature Complexes	2.4%
852	Sinoatrial Block	2.4%
853	Tachycardia, Paroxysmal	2.4%
854	Supraventricular tachycardia	2.4%
855	Tachycardia, Ventricular	2.4%
856	Wolff-Parkinson-White Syndrome	2.4%
857	Tachycardia, Reciprocating	2.4%
858	Aortopulmonary Septal Defect	2.4%
859	Double Outlet Right Ventricle	2.4%
860	Endocardial Cushion Defects	2.4%
861	Myocardial bridging	2.4%
862	Aorticopulmonary Septal Defect	2.4%
863	Noonan Syndrome	2.4%
864	Dermatomyositis	2.4%
865	Corneal Scar	2.4%
866	Muscular Dystrophy, Duchenne	2.4%
867	Retrograde amnesia	2.3%
868	Amnesia, Anterograde	2.3%
869	Rubinstein-Taybi Syndrome	2.3%
870	Dysarthria	2.3%
871	Subacute Bacterial Endocarditis	2.3%
872	Mutism	2.2%
873	Selective Mutism	2.2%
874	Tay-Sachs Disease	2.2%
875	Marfan Syndrome	2.2%
876	Aortic Valve Insufficiency	2.2%
877	Restrictive cardiomyopathy	2.2%
878	Endocardial Fibroelastosis	2.2%
879	Heart Rupture, Post-Infarction	2.2%
880	Mitral Valve Insufficiency	2.2%
881	Mitral Valve Stenosis	2.2%
882	Myocarditis	2.2%
883	Pericarditis, Constrictive	2.2%
884	Pulmonary Valve Insufficiency	2.2%
885	Tricuspid Valve Insufficiency	2.2%
886	Tricuspid Valve Stenosis	2.2%
887	Ventricular Dysfunction, Left	2.2%
888	Right Ventricular Dysfunction	2.2%
889	Endomyocardial Fibrosis	2.2%
890	Carditis	2.2%
891	Heart Failure, Systolic	2.2%
892	Heart Failure, Diastolic	2.2%
893	Niemann-Pick Disease, Type C	2.2%
894	Carcinoid Heart Disease	2.2%
895	Romano-Ward Syndrome	2.2%
896	Fragile X Syndrome	2.1%
897	Alexia, Pure	2%
898	Tachycardia, Atrioventricular Nodal Reentry	2%
899	Tachycardia, Ectopic Atrial	2%
900	Tachycardia, Ectopic Junctional	2%
901	Sinus Tachycardia	2%
902	Torsades de Pointes	2%
903	Accelerated Idioventricular Rhythm	2%
904	Truncus Arteriosus, Persistent	2%
905	Corneal Perforation	2%
906	Sinus Arrhythmia	1.9%
907	Atrial Fibrillation	1.9%
908	Atrial Flutter	1.9%
909	Edema, Cardiac	1.9%
910	Ventricular Fibrillation	1.9%
911	Ventricular Flutter	1.9%
912	Parasystole	1.9%
913	Paroxysmal atrial fibrillation	1.9%
914	Bradycardia	1.9%
915	Diabetic Cardiomyopathies	1.9%
916	Cardiomyopathy, Alcoholic	1.9%
917	Ectopia Cordis	1.9%
918	Sudden Cardiac Death	1.9%
919	Left Ventricular Hypertrophy	1.9%
920	Right Ventricular Hypertrophy	1.9%
921	Single umbilical artery	1.9%
922	Chagas Cardiomyopathy	1.9%
923	Dyspnea, Paroxysmal	1.6%
924	Aortic Valve Prolapse	1.6%
925	Tricuspid Valve Prolapse	1.6%
926	Takotsubo Cardiomyopathy	1.6%
927	Mucopolysaccharidosis II	1.6%
928	Turner Syndrome	1.4%
929	Sinus Arrest, Cardiac	1.4%
930	Kartagener Syndrome	1.2%

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