MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Melorheostosis

(UMLS:C0025239)

Definition:: A form of osteosclerosis extending in a linear track mainly through one of the long bones of the upper and lower limbs.
UMLS ID:: C0025239
MeSH ID:: D008557

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.708.702.593

Synonym(s)

Melorheostosis

Candle wax disease

Flowing hyperostosis

HYPEROSTOSIS, MONOMELIC

LERI SYNDROME

Leri's disease

MELORHEOSTOSIS LERI

Osteopathia hyperostotica congenita

PERIOSTITIS, MONOMELIC

10.

Rheostosis

11.

hyperostosis; monomelic

12.

melorheostosis

13.

monomelic; hyperostosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Dimethyl Fumarate	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Osteopetrosis	49.2%
2	Chondrodysplasia Punctata	36%
3	Enchondromatosis	36%
4	Kashin-Beck Disease	36%
5	Dysostoses	28.5%
6	Hyperostosis	22.7%
7	Osteitis	22.7%
8	Osteitis Deformans	22.7%
9	Osteochondrosis	22.7%
10	Spinal Diseases	22.7%
11	Gigantism	20.6%
12	Osteoarthropathy, Secondary Hypertrophic	20.6%
13	Osteogenesis Imperfecta	18.7%
14	Pectus excavatum	18.4%
15	Platybasia	18%
16	Bone Diseases, Endocrine	16.2%
17	Bone Diseases, Infectious	15.4%
18	Bone neoplasms	15.4%
19	Osteopenia	15.4%
20	Dwarfism	15.4%
21	Osteochondritis	15.3%
22	Fasciitis	15.3%
23	Foot Deformities	15.3%
24	Arthropathy	15.3%
25	Bone Resorption	15.1%
26	Aseptic Necrosis of Bone	15.1%
27	Pectus carinatum	14.9%
28	Klippel-Feil Syndrome	12.4%
29	Synostosis	12.4%
30	Spinal Neoplasms	12.3%
31	Spondylitis	12.3%
32	Ainhum	12.2%
33	Spinal Stenosis	12.2%
34	Spondylosis	12.2%
35	Intervertebral Disc Degeneration	12.2%
36	Jaw Diseases	10.7%
37	Craniofacial Dysostosis	10.5%
38	Contracture	10.3%
39	Fasciitis, Plantar	10.3%
40	Cartilage Diseases	10.2%
41	Foot Diseases	10.2%
42	Myopathy	10.2%
43	Rheumatism	10.2%
44	Chondromalacia	10.2%
45	Congenital Hypothyroidism	10%
46	Arthrogryposis	9.3%
47	Osteomyelitis	8.2%
48	Osteoporosis	8.2%
49	Periostitis	8.2%
50	Bone Demineralization, Pathologic	8.2%
51	Post-Traumatic Osteoporosis	8.2%
52	Alveolar Bone Loss	8.1%
53	Femur Head Necrosis	8.1%
54	Osteolysis	8.1%
55	Fibromyalgia	7.7%
56	Polymyalgia Rheumatica	7.7%
57	Metatarsalgia	7.6%
58	Arthritis	7.6%
59	Bursitis	7.6%
60	Joint Instability	7.6%
61	Myofascial Pain Syndromes	7.6%
62	Rhabdomyolysis	7.6%
63	Synovitis	7.6%
64	Joint laxity	7.6%
65	Polyarthritis	7.6%
66	Frozen shoulder	7.6%
67	Patellofemoral Pain Syndrome	7.6%
68	Eosinophilic Granuloma	7.4%
69	Marfan Syndrome	7.3%
70	Discitis	7.2%
71	Lordosis	7.2%
72	Spondylolysis	7.2%
73	kyphosis	7.2%
74	Craniosynostosis	6.5%
75	Syndactyly	6.5%
76	Brachycephaly	6.5%
77	Basal Cell Nevus Syndrome	6.2%
78	Acromegaly	6.1%
79	Joint Tuberculosis	6.1%
80	Tuberculosis, Osteoarticular	6.1%
81	Bone Tuberculosis	6.1%
82	Rheumatic Fever	5.8%
83	Tuberculosis, Spinal	5.8%
84	Osteoarthritis, Spine	5.5%
85	Mandibulofacial Dysostosis	5.5%
86	Hip Contracture	5.5%
87	Periarthritis	5.5%
88	Rubinstein-Taybi Syndrome	5.3%
89	Gout	5.2%
90	Compartment syndromes	5.1%
91	Maxillary Diseases	5.1%
92	Tendinitis	5.1%
93	Tendinopathy	5.1%
94	Antley-Bixler Syndrome Phenotype	5.1%
95	Hemarthrosis	5%
96	Myositis	5%
97	Tietze's Syndrome	5%
98	Limb Deformities, Congenital	5%
99	Isaacs syndrome	5%
100	Craniofacial Abnormalities	5%
101	Myotonic Disorders	5%
102	Ischemic contracture	5%
103	Cockayne Syndrome	4.9%
104	Goldenhar Syndrome	4.9%
105	Rickets	4.9%
106	Temporomandibular Joint Disorders	4.8%
107	Osteoporosis, Postmenopausal	4.8%
108	Spondylarthropathies	4.8%
109	Acrocephalosyndactylia	4.8%
110	Spondylolisthesis	4.8%
111	Rheumatoid Arthritis	4.7%
112	Juvenile arthritis	4.7%
113	Ankylosing spondylitis	4.6%
114	Poland Syndrome	4.4%
115	Osteoarthritis, Knee	4.3%
116	Pseudohypoparathyroidism	4.1%
117	Bunion	4.1%
118	Fibrodysplasia Ossificans Progressiva	4.1%
119	Myoglobinuria	4.1%
120	Myositis Ossificans	4.1%
121	Tenosynovitis	4.1%
122	Sacroiliitis	4.1%
123	Talipes	3.9%
124	Medial Tibial Stress Syndrome	3.8%
125	Mitochondrial Myopathies	3.8%
126	Muscle Cramp	3.7%
127	Eosinophilia-Myalgia Syndrome	3.7%
128	Gastroschisis	3.7%
129	Arthritis, Psoriatic	3.7%
130	Muscle Rigidity	3.7%
131	Muscle Spasticity	3.7%
132	Cogwheel Rigidity	3.7%
133	Nuchal Rigidity	3.7%
134	Mastoiditis	3.6%
135	Petrositis	3.6%
136	Temporomandibular Joint Dysfunction Syndrome	3.5%
137	Rheumatoid Nodule	3.2%
138	Chronic Fatigue Syndrome	3.2%
139	Nail-Patella Syndrome	3.1%
140	Arthritis, Reactive	3%
141	Giant Cell Epulis	3%
142	Muscle Weakness	3%
143	Musculoskeletal Pain	3%
144	Familial Periodic Paralysis	3%
145	Arthralgia	3%
146	Polyarthralgia	3%
147	Arthritis, Gouty	2.9%
148	Osteomalacia	2.9%
149	Jaw Abnormalities	2.8%
150	Arthritis, Infectious	2.8%
151	Anterior Compartment Syndrome	2.7%
152	Enthesopathy	2.7%
153	Arthritis, Experimental	2.7%
154	Abdominal Compartment Syndrome	2.7%
155	Amelia	2.7%
156	Arachnodactyly	2.7%
157	Ectromelia	2.7%
158	Hemimelia	2.7%
159	Phocomelia	2.7%
160	Sirenomelia	2.7%
161	Polymyositis	2.7%
162	Polydactyly	2.7%
163	Brachydactyly	2.7%
164	Plagiocephaly	2.7%
165	Lower Extremity Deformities, Congenital	2.7%
166	Upper Extremity Deformities, Congenital	2.7%
167	Felty Syndrome	2.6%
168	Laryngomalacia	2.6%
169	Palatal Neoplasms	2.6%
170	Myalgia	2.5%
171	Congenital clubfoot	2.4%
172	Vertical Talus	2.4%
173	Rheumatoid Vasculitis	2.2%
174	Prognathism	2.2%
175	Hip Dislocation	2.1%
176	Shoulder Dislocation	2.1%
177	Hip Dysplasia	2.1%
178	Muscular Dystrophy	2.1%
179	Orbital Myositis	2.1%
180	Dupuytren Contracture	2.1%
181	Pyomyositis	2%
182	Nose Neoplasms	1.9%
183	Sicca Syndrome	1.9%
184	Sjogren's Syndrome	1.9%
185	Renal Osteodystrophy	1.8%
186	Renal rickets	1.8%
187	Maxillofacial Abnormalities	1.7%
188	Myotonia Congenita	1.6%
189	Myotonic Dystrophy	1.6%
190	Bronchomalacia	1.6%
191	Tracheomalacia	1.6%
192	Microcephaly	1.6%
193	Macrocephaly	1.6%
194	Micrognathism	1.6%
195	Pierre Robin Syndrome	1.6%
196	Hypokalemic periodic paralysis	1.6%
197	Shoulder Pain	1.6%
198	Retrognathia	1.4%
199	Mitochondrial Encephalomyopathies	1.4%
200	Welander Distal Myopathy	1.2%
201	Noonan Syndrome	1.2%
202	Cleft Palate	1.1%
203	Holoprosencephaly	1%
204	Dermatomyositis	1%
205	Muscular Dystrophy, Duchenne	1%
206	Porencephaly	1%
207	Familial Hypophosphatemic Rickets	0.7%
208	Radicular Cyst	0.5%
209	MELAS Syndrome	0.5%
210	Kearns-Sayre syndrome	0.4%

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