MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Muscular Dystrophy, Duchenne

(UMLS:C0013264)

Definition:: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
UMLS ID:: C0013264
MeSH ID:: D020388

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.534.500.300

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.668.491.175.500.300

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.322.562|C16.320.577.300

Synonym(s)

Muscular Dystrophy, Duchenne

Benign Duchenne muscular dystrophy

DMD - Duchenne muscular dystrophy

DUCHENNE MUSCULAR DYSTROPHY

Duchenne Muscular Dystrophy

Duchenne de Boulogne muscular dystrophy

Duchenne dystrophy

Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD)

10.

Duchenne myodystrophy

11.

Duchenne pseudohypertrophic muscular dystrophy

12.

Duchenne syndrome

13.

Duchenne type; dystrophy

14.

Duchenne's Muscular Dystrophy

15.

Duchenne-Griesinger

16.

Duchenne-Griesinger syndrome

17.

Duchenne; motor neuron disease

18.

Duchenne; muscular dystrophy

19.

MUSCULAR DYSTROPHY DUCHENNE

20.

MUSCULAR DYSTROPHY, DUCHENNE TYPE

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Losartan	21641384	CTD
2	Methylprednisolone	26930420	CTD
3	Prednisolone	19233868	CTD
4	Resveratrol	26930420	CTD
5	Taurine	26930420	CTD
6	acetovanillone	26930420	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Welander Distal Myopathy	47%
2	Myotonic Dystrophy	43.8%
3	Aicardi's syndrome	28.2%
4	Fragile X Syndrome	26.3%
5	Ichthyosis, X-Linked	24.2%
6	Myasthenic Syndromes, Congenital	24.1%
7	Rett Syndrome	22.7%
8	Multiple Epiphyseal Dysplasia	21.6%
9	Osteochondrodysplasias	21.6%
10	Mucopolysaccharidosis II	21.2%
11	Wiskott-Aldrich Syndrome	21%
12	CHARGE Syndrome	20.9%
13	Familial Periodic Paralysis	20.8%
14	Neoplastic Syndromes, Hereditary	20.6%
15	Nail-Patella Syndrome	20.5%
16	Cystic Fibrosis	20.5%
17	Pelger-Huet Anomaly	19.9%
18	Werner Syndrome	19.9%
19	Cockayne Syndrome	19.9%
20	Menkes Kinky Hair Syndrome	19.9%
21	Alstrom Syndrome	19.8%
22	Albinism	19.8%
23	Anemia, Sickle Cell	19.7%
24	Thalassemia	19.7%
25	Dwarfism	19.1%
26	Myotonia Congenita	18.9%
27	Beckwith-Wiedemann Syndrome	18.8%
28	Wolf-Hirschhorn Syndrome	18.8%
29	Chronic granulomatous disease	18.7%
30	Smith-Magenis syndrome	18.5%
31	Myositis	18%
32	Myotonic Disorders	18%
33	Fibromyalgia	18%
34	Osteogenesis Imperfecta	18%
35	Holoprosencephaly	17.2%
36	Cri-du-Chat Syndrome	17%
37	Down Syndrome	17%
38	Trisomy 21	17%
39	Adrenoleukodystrophy	17%
40	Fabry Disease	16.4%
41	Kartagener Syndrome	16.2%
42	Marfan Syndrome	16.1%
43	Tuberous Sclerosis	15.9%
44	Familial Mediterranean Fever	15.7%
45	Rubinstein-Taybi Syndrome	15.6%
46	Medial Tibial Stress Syndrome	15.6%
47	Mitochondrial Myopathies	15.4%
48	Eosinophilia-Myalgia Syndrome	15.4%
49	Prader-Willi Syndrome	15.1%
50	Autoimmune Lymphoproliferative Syndrome	15.1%
51	Classical Lissencephalies and Subcortical Band Heterotopias	15%
52	Neuronal Ceroid-Lipofuscinoses	15%
53	Angioedemas, Hereditary	14.8%
54	Hepatolenticular Degeneration	14.7%
55	Ectodermal Dysplasia	14.7%
56	Aplasia Cutis Congenita	14.7%
57	Refsum Disease	14.7%
58	Sickle Cell Trait	14.6%
59	Amyloid Neuropathies, Familial	14.5%
60	Smith-Lemli-Opitz Syndrome	14.3%
61	Hypokalemic periodic paralysis	14%
62	Arthrogryposis	14%
63	Williams Syndrome	13.7%
64	Deformity	13.7%
65	Kallmann Syndrome	13.4%
66	Chronic Fatigue Syndrome	13.3%
67	Sjogren-Larsson Syndrome	13.3%
68	Amino Acid Metabolism, Inborn Errors	13.2%
69	Carbohydrate Metabolism, Inborn Errors	13.2%
70	Metal Metabolism, Inborn Errors	13.2%
71	Progeria	13.2%
72	Lysosomal Storage Diseases	13.2%
73	Cytochrome-c Oxidase Deficiency	13.2%
74	Peroxisomal Disorders	13.2%
75	Polycystic Kidney Diseases	13.1%
76	Primary Ciliary Dyskinesia	13%
77	Ataxia Telangiectasia	12.7%
78	Isaacs syndrome	12.5%
79	Canavan Disease	12.4%
80	Alexander Disease	12.4%
81	Glycogen storage disease type II	12.2%
82	Dystonia Musculorum Deformans	12.1%
83	Retinal Dysplasia	12%
84	Galactosemias	12%
85	Urea Cycle Disorders, Inborn	12%
86	Tyrosinemias	12%
87	Aniridia	11.9%
88	Acute Chest Syndrome	11.9%
89	Myalgia	11.9%
90	Epidermolysis Bullosa	11.7%
91	Fetal Diseases	11.5%
92	Cutis Laxa	11.4%
93	Optic Atrophy, Hereditary, Leber	11.4%
94	Retinitis Pigmentosa	11.3%
95	Pigmentary retinopathy	11.3%
96	Porokeratosis	11.3%
97	Keratoderma, Palmoplantar	11.3%
98	Lafora Disease	11.3%
99	Unverricht-Lundborg Syndrome	11.3%
100	Contracture	11.2%
101	Charcot-Marie-Tooth Disease	11.2%
102	Duane Retraction Syndrome	11.1%
103	Mucopolysaccharidosis III	10.7%
104	Congenital Hypothyroidism	10.7%
105	Gout	10.6%
106	Polymyositis	10.6%
107	Hyperphosphaturia	10.6%
108	Zellweger Syndrome	10.5%
109	Brain Diseases, Metabolic, Inborn	10.5%
110	Antley-Bixler Syndrome Phenotype	10.3%
111	Motor Neuron Disease	10.1%
112	Gaucher Disease	10.1%
113	Homocystinuria	10.1%
114	Leigh Disease	10%
115	Porphyrias, Hepatic	10%
116	Myofascial Pain Syndromes	10%
117	Rhabdomyolysis	10%
118	Peutz-Jeghers Syndrome	9.9%
119	Thrombasthenia	9.9%
120	Antithrombin III Deficiency	9.9%
121	Protein C Deficiency	9.9%
122	Afibrinogenemia	9.8%
123	Factor VII Deficiency	9.8%
124	Factor X Deficiency	9.8%
125	Factor XII Deficiency	9.8%
126	Hemophilia A	9.8%
127	Activated Protein C Resistance	9.8%
128	Factor II deficiency	9.8%
129	Factor VIII Deficiency	9.8%
130	Factor V deficiency	9.8%
131	Factor XI Deficiency	9.8%
132	Hypoprothrombinemias	9.8%
133	Muscular Dystrophy, Duchenne	9.8%
134	Fanconi Anemia	9.8%
135	Alkaptonuria	9.8%
136	Glycogen Storage Disease	9.8%
137	Hypophosphatasia	9.8%
138	Propionic acidemia	9.8%
139	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
140	Cystinosis	9.8%
141	Anemia, Diamond-Blackfan	9.7%
142	Polycystic Kidney, Autosomal Dominant	9.7%
143	Pseudoxanthoma Elasticum	9.7%
144	Polymyalgia Rheumatica	9.6%
145	Mobius Syndrome	9.4%
146	Hyperkeratosis, Epidermolytic	9.4%
147	Basal Cell Nevus Syndrome	9.3%
148	Orbital Myositis	9.2%
149	Tay-Sachs Disease	9.2%
150	Pyomyositis	9.1%
151	Huntington Disease	9.1%
152	Meconium Aspiration Syndrome	9%
153	Multiple Endocrine Neoplasia	9%
154	Carbamoyl-Phosphate Synthase I Deficiency Disease	9%
155	Neuromuscular Junction Diseases	9%
156	Peripheral Nervous System Diseases	9%
157	Xeroderma Pigmentosum	8.9%
158	Dermatitis, Atopic	8.8%
159	Niemann-Pick Disease, Type C	8.8%
160	Ischemic contracture	8.7%
161	Stiff-Person Syndrome	8.6%
162	Muscular Dystrophy	8.5%
163	Compartment syndromes	8.4%
164	Tendinitis	8.4%
165	Tendinopathy	8.4%
166	Hypolipoproteinemias	8.4%
167	Papillon-Lefevre Disease	8.4%
168	Hyperlipidemia, Familial Combined	8.3%
169	Hyperlipoproteinemia Type III	8.3%
170	Xeroderma	8.3%
171	Muscle Cramp	8.3%
172	MELAS Syndrome	8.2%
173	Glycogen Storage Disease Type I	8.1%
174	Glycogen Storage Disease Type V	8.1%
175	Abdominal Cramps	8%
176	Abnormalities, Drug-Induced	8%
177	Amniotic Band Syndrome	8%
178	Asphyxia Neonatorum	8%
179	Infant, Premature, Diseases	8%
180	Situs Inversus	8%
181	Infantile Colic	8%
182	Friedreich Ataxia	7.9%
183	Arthritis, Gouty	7.9%
184	Behcet Syndrome	7.9%
185	Pectus carinatum	7.8%
186	Muscle Rigidity	7.7%
187	Muscle Spasticity	7.7%
188	Cogwheel Rigidity	7.7%
189	Nuchal Rigidity	7.7%
190	Anencephaly	7.7%
191	Dural Arteriovenous Fistula	7.7%
192	Pseudohypoparathyroidism	7.7%
193	Mitochondrial Encephalomyopathies	7.6%
194	Pectus excavatum	7.6%
195	Klinefelter Syndrome	7.3%
196	Lactose Intolerance	7.3%
197	Variegate Porphyria	7.3%
198	Acute intermittent porphyria	7.3%
199	Porphyria Cutanea Tarda	7.3%
200	Hyperhomocysteinemia	7.3%
201	Muscle Weakness	7.3%
202	Renal Aminoacidurias	7.3%
203	Fanconi Syndrome	7.3%
204	Pseudohypoaldosteronism	7.3%
205	Liddle Syndrome	7.3%
206	Hyperlipoproteinemia Type IV	7.3%
207	Hyperlipoproteinemia Type V	7.3%
208	Limb Deformities, Congenital	7.2%
209	Craniofacial Abnormalities	7.2%
210	Klippel-Feil Syndrome	7.1%
211	Synostosis	7.1%
212	Craniosynostosis	7.1%
213	Syndactyly	7.1%
214	Brachycephaly	7.1%
215	Maxillofacial Abnormalities	7%
216	Acrocephalosyndactylia	7%
217	Hydranencephaly	6.9%
218	Neural Tube Defects	6.9%
219	Tethered Cord Syndrome	6.9%
220	Iniencephaly	6.9%
221	Craniorachischisis	6.9%
222	Exencephaly	6.9%
223	Septo-Optic Dysplasia	6.9%
224	Cortical Dysplasia	6.9%
225	Malformations of Cortical Development	6.9%
226	Hypoalphalipoproteinemias	6.9%
227	Eye Abnormalities	6.9%
228	Cardiovascular Abnormalities	6.9%
229	Hydrops Fetalis	6.9%
230	Turner Syndrome	6.8%
231	Poliomyelitis	6.8%
232	Skin Abnormalities	6.7%
233	Lymphatic Abnormalities	6.7%
234	Congenital Microtia	6.7%
235	Anemia, Neonatal	6.6%
236	Persistent Fetal Circulation Syndrome	6.6%
237	Complex Regional Pain Syndromes	6.6%
238	Congenital diaphragmatic hernia	6.6%
239	Umbilical hernia	6.6%
240	Hip Contracture	6.6%
241	Multiple Endocrine Neoplasia Type 1	6.6%
242	Nephroblastoma	6.5%
243	Renal tubular acidosis	6.5%
244	Temporomandibular Joint Dysfunction Syndrome	6.4%
245	Dandy-Walker Syndrome	6.4%
246	Congenital nystagmus	6.4%
247	Microcephaly	6.3%
248	Macrocephaly	6.3%
249	Familial Hypophosphatemic Rickets	6.3%
250	Musculoskeletal Pain	6.2%
251	Central Nervous System Cysts	6.2%
252	Platybasia	6.2%
253	Gastroschisis	6.1%
254	Bone Diseases	6.1%
255	Fasciitis	6.1%
256	Foot Deformities	6.1%
257	Arthropathy	6.1%
258	Toxoplasmosis, Congenital	6.1%
259	Cystinuria	6%
260	Temporomandibular Joint Disorders	6%
261	Adenomatous Polyposis Coli	6%
262	Jaw Abnormalities	6%
263	Urogenital Abnormalities	5.9%
264	Fibrodysplasia Ossificans Progressiva	5.9%
265	Myoglobinuria	5.9%
266	Myositis Ossificans	5.9%
267	Tenosynovitis	5.9%
268	Spinal Muscular Atrophy	5.9%
269	Progressive Muscular Atrophy	5.9%
270	Neonatal Abstinence Syndrome	5.8%
271	Cranial nerve diseases	5.8%
272	Demyelinating Diseases	5.8%
273	Demyelination	5.8%
274	Chronobiology Disorders	5.8%
275	Peripheral Nerve Injuries	5.8%
276	Dextrocardia	5.7%
277	Fetal Growth Retardation	5.7%
278	Myasthenia Gravis	5.7%
279	Fetal Hypoxia	5.7%
280	Fetal Alcohol Spectrum Disorders	5.7%
281	Polyradiculoneuropathy	5.6%
282	Polyradiculoneuritis	5.6%
283	Guillain-Barre Syndrome	5.6%
284	Syphilis, Congenital	5.6%
285	Osteoarthropathy, Secondary Hypertrophic	5.6%
286	Fasciitis, Plantar	5.6%
287	Amyotrophic Lateral Sclerosis	5.5%
288	Progressive bulbar palsy	5.5%
289	Bulbar palsy	5.5%
290	Poland Syndrome	5.5%
291	Porencephaly	5.5%
292	Dermatomyositis	5.4%
293	Causalgia	5.4%
294	Glycosuria, Renal	5.3%
295	Jaw Diseases	5.3%
296	Prune Belly Syndrome	5.2%
297	Twins, Conjoined	5.2%
298	Waardenburg Syndrome	5.2%
299	Cartilage Diseases	5.2%
300	Foot Diseases	5.2%
301	Rheumatism	5.2%
302	Chondromalacia	5.2%
303	Craniofacial Dysostosis	5.1%
304	POEMS Syndrome	5.1%
305	Cleft Palate	5%
306	Congenital Hyperinsulinism	5%
307	Trauma, Nervous System	5%
308	Botulism	5%
309	Chorioamnionitis	5%
310	Noonan Syndrome	5%
311	Anterior Compartment Syndrome	4.9%
312	Enthesopathy	4.9%
313	Abdominal Compartment Syndrome	4.9%
314	Neuritis	4.9%
315	Polyneuritis	4.9%
316	Radiculitis	4.9%
317	Polyneuropathy	4.9%
318	Mononeuritis	4.9%
319	Mononeuropathies	4.9%
320	Brachial Plexus Neuropathies	4.9%
321	Radiculopathy	4.9%
322	Mononeuropathy Multiplex	4.9%
323	Nerve Root Compression	4.9%
324	Amelia	4.9%
325	Arachnodactyly	4.9%
326	Ectromelia	4.9%
327	Hemimelia	4.9%
328	Phocomelia	4.9%
329	Sirenomelia	4.9%
330	Polydactyly	4.9%
331	Brachydactyly	4.9%
332	Plagiocephaly	4.9%
333	Lower Extremity Deformities, Congenital	4.9%
334	Upper Extremity Deformities, Congenital	4.9%
335	Talipes	4.9%
336	Brachial Plexus Neuritis	4.9%
337	Laryngomalacia	4.9%
338	Neuralgic Amyotrophy	4.9%
339	Nervous System Neoplasms	4.9%
340	Neurologic Manifestations	4.9%
341	Neurotoxicity Syndromes	4.9%
342	Lambert-Eaton Myasthenic Syndrome	4.8%
343	Osteochondritis	4.8%
344	Metatarsalgia	4.8%
345	Scimitar Syndrome	4.7%
346	Restless Legs Syndrome	4.7%
347	Meningomyelocele	4.6%
348	Spina Bifida	4.6%
349	Denys-Drash Syndrome	4.6%
350	Prognathism	4.6%
351	Multiple System Atrophy	4.6%
352	Micrognathism	4.5%
353	Pierre Robin Syndrome	4.5%
354	Leukomalacia, Periventricular	4.5%
355	Ocular Motility Disorders	4.4%
356	Cyclophoria	4.4%
357	Anophthalmos	4.4%
358	Anus, Imperforate	4.4%
359	Microphthalmos	4.4%
360	Paralysis, Obstetric	4.4%
361	Retinopathy of Prematurity	4.4%
362	Anorectal Malformations	4.4%
363	Abnormalities, Radiation-Induced	4.4%
364	Bloom Syndrome	4.4%
365	Bronchopulmonary Dysplasia	4.4%
366	Subacute Combined Degeneration	4.3%
367	Dupuytren Contracture	4.2%
368	Sleep Wake Disorders	4.2%
369	Acrodynia	4.2%
370	Retrognathia	4.1%
371	Diabetic Neuropathies	4.1%
372	Diabetic Amyotrophy	4.1%
373	Diabetic Autonomic Neuropathy	4.1%
374	Neuralgia	4.1%
375	Neuropathic pain	4.1%
376	Tarsal Tunnel Syndrome	4.1%
377	Cauda Equina Syndrome	4.1%
378	Meningocele	4%
379	Encephalocele	4%
380	Ophthalmia Neonatorum	3.9%
381	Encephalomyelitis	3.9%
382	Prion Diseases	3.9%
383	Autonomic Dysreflexia	3.9%
384	Blepharophimosis	3.8%
385	Laryngostenosis	3.8%
386	Mouth Abnormalities	3.8%
387	Respiratory Distress Syndrome, Newborn	3.8%
388	Congenital clubfoot	3.8%
389	Vertical Talus	3.8%
390	Ophthalmoplegic Migraine	3.8%
391	Reflex Sympathetic Dystrophy	3.8%
392	Esophageal Atresia	3.8%
393	Intestinal Atresia	3.8%
394	Horseshoe Kidney	3.8%
395	Rheumatic Fever	3.8%
396	Acrodermatitis	3.8%
397	Lymphangiectasis, Intestinal	3.8%
398	Gianotti-Crosti Syndrome	3.8%
399	Miller Fisher Syndrome	3.7%
400	Bronchomalacia	3.7%
401	Tracheomalacia	3.7%
402	Hand-Arm Vibration Syndrome	3.7%
403	Dermal Sinus	3.5%
404	Spina Bifida Cystica	3.5%
405	Spina Bifida Occulta	3.5%
406	Lissencephaly	3.5%
407	Polymicrogyria	3.5%
408	Pachygyria	3.5%
409	Schizencephaly	3.5%
410	Periventricular Nodular Heterotopia	3.5%
411	Carpal Tunnel Syndrome	3.5%
412	Sciatica	3.5%
413	Kearns-Sayre syndrome	3.5%
414	Osteoarthritis, Spine	3.5%
415	Mandibulofacial Dysostosis	3.4%
416	Spinal Cord Injuries	3.4%
417	Choanal Atresia	3.4%
418	Tracheobronchomegaly	3.4%
419	Laryngocele	3.4%
420	Rheumatoid Arthritis	3.4%
421	Choledochal Cyst	3.4%
422	Hermaphroditism	3.4%
423	Disorders of Sex Development	3.4%
424	Juvenile arthritis	3.4%
425	Goldenhar Syndrome	3.3%
426	Cryptorchidism	3.3%
427	Hypospadias	3.3%
428	Asterixis	3.3%
429	Ballismus	3.3%
430	Arthritis	3.3%
431	Bone Diseases, Developmental	3.3%
432	Bursitis	3.3%
433	Hyperostosis	3.3%
434	Joint Instability	3.3%
435	Osteitis	3.3%
436	Osteitis Deformans	3.3%
437	Osteochondrosis	3.3%
438	Spinal Diseases	3.3%
439	Synovitis	3.3%
440	Joint laxity	3.3%
441	Polyarthritis	3.3%
442	Frozen shoulder	3.3%
443	Patellofemoral Pain Syndrome	3.3%
444	Marchiafava-Bignami Disease	3.3%
445	Periarthritis	3.3%
446	Parkinson Disease	3.3%
447	Meningoencephalitis	3.3%
448	Ectopia Cordis	3.3%
449	Single umbilical artery	3.3%
450	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.3%
451	Nesidioblastosis	3.3%
452	Kernicterus	3.2%
453	Lewy Body Disease	3.1%
454	Myasthenia Gravis, Autoimmune, Experimental	3.1%
455	Pneumocephalus	3.1%
456	Brain Diseases	3%
457	Dysautonomia	3%
458	Meningitis	3%
459	Movement Disorders	3%
460	Pachymeningitis	3%
461	Spinal Cord Diseases	3%
462	Vagus Nerve Disorder	3%
463	Glossopharyngeal Neuralgia	3%
464	Abducens Nerve Diseases	3%
465	Heavy Metal Poisoning, Nervous System	3%
466	Tauopathies	3%
467	Trochlear Nerve Diseases	3%
468	Sleep Disorders, Circadian Rhythm	3%
469	Bladder Exstrophy	2.9%
470	Epispadias	2.9%
471	Sciatic Neuropathy	2.9%
472	Ulnar Neuropathies	2.9%
473	Lesion of Sciatic Nerve	2.9%
474	Ulnar Neuritis	2.9%
475	Radial nerve compression	2.9%
476	Radial Tunnel Syndrome	2.9%
477	Peroneal Neuropathies	2.9%
478	Radial Neuropathy	2.9%
479	Median Neuropathy	2.9%
480	Sciatic Nerve Palsy	2.9%
481	Femoral Neuropathy	2.9%
482	Tibial Neuropathy	2.9%
483	Ulnar Nerve Palsy	2.9%
484	Radial nerve palsy	2.9%
485	Multicystic Dysplastic Kidney	2.9%
486	Bone Diseases, Endocrine	2.9%
487	Myelitis, Transverse	2.9%
488	Neuritis, Autoimmune, Experimental	2.9%
489	Neuroleptic Malignant Syndrome	2.8%
490	Myelinolysis, Central Pontine	2.8%
491	Dyskinesia, Drug-Induced	2.8%
492	Gigantism	2.8%
493	Spinal Neoplasms	2.8%
494	Spondylitis	2.8%
495	Progressive supranuclear palsy	2.8%
496	Aortic coarctation	2.8%
497	Cor Triatriatum	2.8%
498	Coronary Vessel Anomalies	2.8%
499	Dental Enamel Hypoplasia	2.8%
500	Patent ductus arteriosus	2.8%
501	Ebstein Anomaly	2.8%
502	Heart Septal Defects	2.8%
503	Hyaline Membrane Disease	2.8%
504	Hypodontia	2.8%
505	Macrostomia	2.8%
506	Microstomia	2.8%
507	Tetralogy of Fallot	2.8%
508	Transposition of Great Vessels	2.8%
509	Hypoplastic Left Heart Syndrome	2.8%
510	May-Thurner Syndrome	2.8%
511	Bone Diseases, Infectious	2.8%
512	Bone neoplasms	2.8%
513	Maxillary Diseases	2.8%
514	Osteopenia	2.8%
515	Wolff-Parkinson-White Syndrome	2.8%
516	Cubital Tunnel Syndrome	2.8%
517	Bone Resorption	2.8%
518	Hemarthrosis	2.8%
519	Tietze's Syndrome	2.8%
520	Aseptic Necrosis of Bone	2.8%
521	Myelitis	2.7%
522	Osteoarthritis, Knee	2.7%
523	Opsoclonus-Myoclonus Syndrome	2.7%
524	Hyperandrogenism	2.7%
525	Ankylosing spondylitis	2.7%
526	Epidural Abscess	2.7%
527	Olfactory Nerve Injuries	2.7%
528	Striatonigral Degeneration	2.6%
529	Leukoencephalitis, Acute Hemorrhagic	2.6%
530	Akathisia, Drug-Induced	2.6%
531	Neuromyelitis Optica	2.6%
532	Central Nervous System Infection	2.6%
533	Optic Neuropathy	2.6%
534	MPTP Poisoning	2.6%
535	Facial Nerve Diseases	2.5%
536	Craniocerebral Trauma	2.5%
537	Parasomnia	2.5%
538	Dyssomnias	2.5%
539	Vestibulocochlear Nerve Diseases	2.5%
540	Decerebrate State	2.5%
541	Hemiparesis	2.5%
542	Meningism	2.5%
543	Paresis	2.5%
544	Seizures	2.5%
545	Sensation Disorders	2.5%
546	Central Nervous System Neoplasms	2.5%
547	Complex partial seizures	2.5%
548	Monoparesis	2.5%
549	Neurogenic Inflammation	2.5%
550	Gait Disorders, Neurologic	2.5%
551	Neuromuscular Manifestations	2.5%
552	Sweating, Gustatory	2.5%
553	Thoracic Outlet Syndrome	2.5%
554	Auriculotemporal Syndrome	2.5%
555	Horner Syndrome	2.5%
556	Long QT Syndrome	2.5%
557	Tricuspid Atresia	2.5%
558	Arrhythmogenic Right Ventricular Dysplasia	2.5%
559	Gonadal Dysgenesis	2.5%
560	Adrenogenital Syndrome	2.5%
561	Ovotesticular Disorders of Sex Development	2.5%
562	Encephalomyelitis, Acute Disseminated	2.4%
563	Facial Nerve Injuries	2.4%
564	Shy-Drager Syndrome	2.4%
565	Brain Injuries	2.4%
566	Brain Neoplasms	2.3%
567	Multiple Sclerosis	2.3%
568	Spinal Cord Neoplasms	2.3%
569	Rheumatoid Nodule	2.3%
570	Arthritis, Psoriatic	2.3%
571	Aortopulmonary Septal Defect	2.3%
572	Double Outlet Right Ventricle	2.3%
573	Endocardial Cushion Defects	2.3%
574	Myocardial bridging	2.3%
575	Aorticopulmonary Septal Defect	2.3%
576	Leukoencephalopathy, Progressive Multifocal	2.2%
577	Vasculitis, Central Nervous System	2.2%
578	Jet Lag Syndrome	2.2%
579	Pupil Disorders	2.2%
580	Neurobehavioral Manifestations	2.2%
581	Subdural Effusion	2.2%
582	Parkinsonian Disorders	2.2%
583	Nocturnal Myoclonus Syndrome	2.2%
584	Paraneoplastic Encephalomyelitis	2.2%
585	Uveomeningoencephalitic Syndrome	2.1%
586	Sturge-Weber Syndrome	2.1%
587	Vertigo	2.1%
588	Alcohol-Induced Disorders, Nervous System	2.1%
589	Giant Cell Epulis	2.1%
590	neurofibroma	2.1%
591	Truncus Arteriosus, Persistent	2.1%
592	Brain Abscess	2.1%
593	Ophthalmoplegia	2.1%
594	External Ophthalmoplegia	2.1%
595	Arthralgia	2.1%
596	Polyarthralgia	2.1%
597	Felty Syndrome	2%
598	Romano-Ward Syndrome	2%
599	Limbic Encephalitis	2%
600	Ainhum	2%
601	Bunion	2%
602	Dysostoses	2%
603	Spinal Stenosis	2%
604	Spondylosis	2%
605	Intervertebral Disc Degeneration	2%
606	Sacroiliitis	2%
607	Polyradiculopathy	1.9%
608	Arthritis, Reactive	1.9%
609	Voice Disorders	1.9%
610	Voice Disturbance	1.9%
611	Spondylarthropathies	1.9%
612	Scrapie	1.9%
613	Central Cord Syndrome	1.9%
614	Presenile dementia	1.9%
615	Senile dementia	1.9%
616	Meningitis, Bacterial	1.9%
617	Meningitis, Fungal	1.9%
618	Chorea	1.9%
619	Discitis	1.9%
620	Vocal Cord Paralysis	1.9%
621	Lupus Vasculitis, Central Nervous System	1.8%
622	Eosinophilic Granuloma	1.8%
623	Epilepsy, Post-Traumatic	1.8%
624	Rheumatoid Vasculitis	1.8%
625	Acromegaly	1.8%
626	Arthritis, Infectious	1.7%
627	Amblyopia	1.6%
628	Reflex, Abnormal	1.6%
629	Hyporeflexia	1.6%
630	Hyperreflexia	1.6%
631	Osteomyelitis	1.6%
632	Osteoporosis	1.6%
633	Periostitis	1.6%
634	Bone Demineralization, Pathologic	1.6%
635	Post-Traumatic Osteoporosis	1.6%
636	Arthritis, Experimental	1.6%
637	Akinetic Mutism	1.6%
638	Anoxic Encephalopathy	1.6%
639	Arachnoiditis	1.6%
640	Basal Ganglia Diseases	1.6%
641	Brain Damage, Chronic	1.6%
642	Cerebellar Diseases	1.6%
643	Encephalitis	1.6%
644	Encephalomalacia	1.6%
645	Epilepsy	1.6%
646	Hydrocephalus	1.6%
647	Congenital Hydrocephalus	1.6%
648	Hypothalamic Diseases	1.6%
649	Aseptic Meningitis	1.6%
650	Syringomyelia	1.6%
651	Thalamic Diseases	1.6%
652	Intracranial Hypertension	1.6%
653	Aura	1.6%
654	Leukoencephalopathy	1.6%
655	Essential Tremor	1.6%
656	Neuroaxonal Dystrophies	1.6%
657	Familial Tremor	1.6%
658	Headache Disorders	1.6%
659	Intracranial Hypotension	1.6%
660	Brain Edema	1.6%
661	Brain Hypoxia	1.6%
662	Aqueductal Stenosis	1.6%
663	Pneumorrhachis	1.6%
664	Writer's Cramp	1.6%
665	Sicca Syndrome	1.6%
666	Sjogren's Syndrome	1.6%
667	Paraneoplastic Cerebellar Degeneration	1.6%
668	Alveolar Bone Loss	1.6%
669	Femur Head Necrosis	1.6%
670	Osteolysis	1.6%
671	Alcohol Withdrawal Seizures	1.6%
672	Cerebrospinal Fluid Otorrhea	1.6%
673	Cerebrospinal Fluid Rhinorrhea	1.6%
674	Arteriovenous fistula	1.6%
675	Meige Syndrome	1.6%
676	Gait Ataxia	1.6%
677	Cerebral Ventriculitis	1.6%
678	Tuberculosis, Spinal	1.6%
679	Dementia, Vascular	1.5%
680	Brain Hemorrhage, Traumatic	1.5%
681	Brain Death	1.5%
682	Coma, Post-Head Injury	1.5%
683	Palatal Neoplasms	1.5%
684	Carotid Artery Injuries	1.5%
685	Akathisia	1.4%
686	Restlessness	1.4%
687	Psychomotor Agitation	1.4%
688	Hip Dislocation	1.4%
689	Shoulder Dislocation	1.4%
690	Hip Dysplasia	1.4%
691	Cerebellar Neoplasms	1.4%
692	Joint Tuberculosis	1.4%
693	Tuberculosis, Osteoarticular	1.4%
694	Bone Tuberculosis	1.4%
695	Creutzfeldt-Jakob disease	1.4%
696	Basal Ganglia Cerebrovascular Disease	1.4%
697	Brain Injuries, Diffuse	1.4%
698	Traumatic Brain Injury	1.4%
699	Cerebellar Ataxia	1.4%
700	Supratentorial Neoplasms	1.4%
701	Torticollis	1.4%
702	Multiple Sclerosis, Chronic Progressive	1.4%
703	Multiple Sclerosis, Relapsing-Remitting	1.4%
704	Brain Diseases, Metabolic	1.4%
705	Cerebrovascular Disorders	1.4%
706	Optic Atrophy	1.4%
707	Optic Neuritis	1.4%
708	Papilledema	1.4%
709	Strabismus	1.4%
710	Tolosa-Hunt Syndrome	1.4%
711	Cerebrovascular Insufficiency	1.4%
712	Arsenic Poisoning	1.4%
713	Dementia	1.4%
714	Central Nervous System Fungal Infections	1.4%
715	Conus Medullaris Syndrome	1.4%
716	Spinal Cord Vascular Diseases	1.4%
717	Facial Injuries	1.4%
718	Facial Neuralgia	1.4%
719	Sleep Talking	1.4%
720	Manganese Poisoning	1.4%
721	Sleep Disorders, Intrinsic	1.4%
722	Orthostatic intolerance	1.4%
723	Anosmia	1.4%
724	Ataxia	1.4%
725	Athetosis	1.4%
726	Catalepsy	1.4%
727	Dystonia	1.4%
728	Hemiplegia	1.4%
729	Locked-In Syndrome	1.4%
730	Meningeal Neoplasms	1.4%
731	Muscle Hypertonia	1.4%
732	Muscle hypotonia	1.4%
733	Myoclonus	1.4%
734	Myotonia	1.4%
735	Paraplegia	1.4%
736	Pseudobulbar Palsy	1.4%
737	Quadriplegia	1.4%
738	Spasm	1.4%
739	Spastic Paraplegia	1.4%
740	Status Epilepticus	1.4%
741	Taste Disorders	1.4%
742	Tremor	1.4%
743	Monoplegia	1.4%
744	Hypokinesia	1.4%
745	Paraparesis	1.4%
746	Bradykinesia	1.4%
747	Waxy flexibility	1.4%
748	Action Tremor	1.4%
749	Resting Tremor	1.4%
750	Dysosmia	1.4%
751	Quadriparesis	1.4%
752	Mercury Poisoning, Nervous System	1.4%
753	Olfaction Disorders	1.4%
754	Myokymia	1.4%
755	Lead Poisoning, Nervous System	1.4%
756	Vestibular Neuronitis	1.4%
757	Somatosensory Disorders	1.4%
758	Hyperkinesia	1.4%
759	Intention tremor	1.4%
760	Posterior Leukoencephalopathy Syndrome	1.4%
761	Posterior reversible encephalopathy syndrome	1.4%
762	Chondrodysplasia Punctata	1.3%
763	Enchondromatosis	1.3%
764	Lordosis	1.3%
765	Osteosclerosis	1.3%
766	Spondylolysis	1.3%
767	kyphosis	1.3%
768	Kashin-Beck Disease	1.3%
769	Vertebral Artery Dissection	1.3%
770	Amnesia, Transient Global	1.3%
771	Optic Nerve Glioma	1.3%
772	Gait Apraxia	1.3%
773	Tuberculosis, Meningeal	1.3%
774	Acoustic Neuroma	1.3%
775	Rickets	1.2%
776	Shoulder Pain	1.2%
777	Alice in Wonderland Syndrome	1.2%
778	Vision Disorders	1.2%
779	Metamorphopsia	1.2%
780	Visual Impairment	1.2%
781	Optic Neuropathy, Ischemic	1.2%
782	Anterior Ischemic Optic Neuropathy	1.2%
783	Central Nervous System Bacterial Infections	1.2%
784	Facial Hemiatrophy	1.2%
785	Melkersson-Rosenthal Syndrome	1.2%
786	Anisocoria	1.2%
787	Confusion	1.2%
788	Facial paralysis	1.2%
789	Lethargy	1.2%
790	Memory Disorders	1.2%
791	Perceptual Disorders	1.2%
792	Psychomotor Disorders	1.2%
793	Tonic Pupil	1.2%
794	Anhedonia	1.2%
795	Disorientation	1.2%
796	Facial Paresis	1.2%
797	Memory Loss	1.2%
798	Hemisensory Neglect	1.2%
799	Dysacusis	1.2%
800	Toxoplasmosis, Cerebral	1.2%
801	Sleep Bruxism	1.2%
802	Muscular Atrophy	1.2%
803	Respiratory Paralysis	1.2%
804	Tetany	1.2%
805	Vascular Headaches	1.2%
806	Neurofibrosarcoma	1.2%
807	Hypoxia-Ischemia, Brain	1.2%
808	Tardive Dyskinesia	1.2%
809	Persistent Vegetative State	1.2%
810	Brain Concussion	1.1%
811	Osteoporosis, Postmenopausal	1.1%
812	Myoclonic Epilepsy	1.1%
813	Epilepsy, Temporal Lobe	1.1%
814	Epilepsy, Rolandic	1.1%
815	Benign Rolandic Epilepsy	1.1%
816	Consciousness Disorders	1%
817	Mental Retardation	1%
818	Depressed Level of Consciousness	1%
819	Mental deficiency	1%
820	Intellectual Disability	1%
821	Bell Palsy	1%
822	Giant Cell Arteritis	1%
823	Temporal Arteritis	1%
824	Catatonia	1%
825	Herpes Zoster Oticus	1%
826	Aphonia	1%
827	Sleep Deprivation	1%
828	Dysphonia	1%
829	Meningitis, Cryptococcal	1%
830	Meningitis, Listeria	1%
831	Meningitis, Haemophilus	1%
832	Meningitis, Pneumococcal	1%
833	Frontotemporal dementia	1%
834	Auditory Perceptual Disorders	1%
835	Cerebral Palsy	1%
836	Epilepsies, Partial	1%
837	Epilepsy, Generalized	1%
838	Pseudotumor Cerebri	1%
839	Hypertensive Encephalopathy	1%
840	Simple Partial Seizures	1%
841	Epilepsy, Reflex	1%
842	Postural Orthostatic Tachycardia Syndrome	1%
843	Headache Disorders, Primary	1%
844	Headache Disorders, Secondary	1%
845	Medication overuse headache	1%
846	Melorheostosis	1%
847	Osteopetrosis	1%
848	Spondylolisthesis	1%
849	Pituitary Adenoma	1%
850	Pituitary Neoplasms	1%
851	Mastoiditis	0.9%
852	Petrositis	0.9%
853	Diffuse Axonal Injury	0.9%
854	Brain Stem Neoplasms	0.9%
855	Basal Ganglia Hemorrhage	0.9%
856	Subarachnoid Hemorrhage, Traumatic	0.9%
857	Carotid Artery, Internal, Dissection	0.9%
858	Pituitary Diseases	0.8%
859	Hoarseness	0.8%
860	Subacute Sclerosing Panencephalitis	0.8%
861	Alcohol Withdrawal Delirium	0.8%
862	Pituitary Apoplexy	0.8%
863	Carotid Artery Diseases	0.8%
864	Brain Ischemia	0.8%
865	Esotropia	0.8%
866	Exotropia	0.8%
867	Hypotension, Orthostatic	0.8%
868	Sleep Apnea Syndromes	0.8%
869	Cerebrovascular accident	0.8%
870	Kluver-Bucy Syndrome	0.8%
871	Vasospasm, Intracranial	0.8%
872	Spinal Cord Ischemia	0.8%
873	Intracranial Arterial Diseases	0.8%
874	Post-Exercise Hypotension	0.8%
875	Disorders of Excessive Somnolence	0.8%
876	Sleep Initiation and Maintenance Disorders	0.8%
877	Night Terrors	0.8%
878	Somnambulism	0.8%
879	Trigeminal Nerve Disorder	0.8%
880	Transient Insomnia	0.8%
881	Sleep Paralysis	0.8%
882	Chronic Insomnia	0.8%
883	REM Sleep Behavior Disorder	0.8%
884	Hypersomnia	0.8%
885	Dysgeusia	0.8%
886	Formication	0.8%
887	Hyperalgesia	0.8%
888	Hyperesthesia	0.8%
889	Hypesthesia	0.8%
890	Language Disorders	0.8%
891	Numbness	0.8%
892	Paresthesia	0.8%
893	Paraparesis, Spastic	0.8%
894	Trismus	0.8%
895	Epilepsia Partialis Continua	0.8%
896	Hypogeusia	0.8%
897	Meningeal Carcinomatosis	0.8%
898	Brown-Sequard Syndrome	0.8%
899	Lockjaw	0.8%
900	Allodynia	0.8%
901	Lead Poisoning, Nervous System, Childhood	0.8%
902	Lead Poisoning, Nervous System, Adult	0.8%
903	Ageusia	0.8%
904	Brain Contusion	0.8%
905	Tuberculosis, Central Nervous System	0.8%
906	Osteomalacia	0.8%
907	Brain Infarction	0.8%
908	Juvenile Myoclonic Epilepsy	0.8%
909	Myoclonic Epilepsies, Progressive	0.8%
910	Hematoma, Subdural	0.7%
911	Hematoma, Epidural, Cranial	0.7%
912	Eye Injuries	0.7%
913	Alexia	0.7%
914	Dyslexia	0.7%
915	Diplopia	0.7%
916	Scotoma	0.7%
917	Photophobia	0.7%
918	Hemifacial Spasm	0.7%
919	Amaurosis	0.7%
920	Blindness	0.7%
921	Reye Syndrome	0.7%
922	Neuroaspergillosis	0.7%
923	Intracranial Embolism and Thrombosis	0.7%
924	Hepatic Encephalopathy	0.7%
925	Agnosia	0.7%
926	Apraxias	0.7%
927	Hallucinations	0.7%
928	Hemianopsia	0.7%
929	Hyperacusis	0.7%
930	Tinnitus	0.7%
931	Visual Agnosia	0.7%
932	Anosognosia	0.7%
933	Wernicke-Korsakoff Syndrome	0.7%
934	Phonophobia	0.7%
935	Hearing Loss	0.7%
936	Sarcopenia	0.7%
937	Choroid Plexus Papilloma	0.7%
938	Putaminal Hemorrhage	0.7%
939	Post-Traumatic Headache	0.6%
940	Tension Headache	0.6%
941	Epilepsy, Complex Partial	0.6%
942	Migraine Disorders	0.6%
943	Abdominal Migraine	0.6%
944	Status Migrainosus	0.6%
945	Cervicogenic Headache	0.6%
946	Infarction, Middle Cerebral Artery	0.6%
947	Infarction, Anterior Cerebral Artery	0.6%
948	Infarction, Posterior Cerebral Artery	0.6%
949	Pseudorabies	0.6%
950	Moyamoya Disease	0.6%
951	Amnesia	0.6%
952	Delirium	0.6%
953	Dissociative Amnesia	0.6%
954	Color blindness	0.6%
955	Global Amnesia	0.6%
956	Meningioma	0.6%
957	Nose Neoplasms	0.6%
958	Neurosyphilis	0.6%
959	Cerebral Infarction	0.6%
960	Brain Stem Infarctions	0.6%
961	Renal Osteodystrophy	0.6%
962	Renal rickets	0.6%
963	West Nile Fever	0.6%
964	Empty Sella Syndrome	0.5%
965	Hyperpituitarism	0.5%
966	Hypopituitarism	0.5%
967	Hypophysitis	0.5%
968	Wernicke Encephalopathy	0.5%
969	AIDS Dementia Complex	0.5%
970	Cerebral Arterial Diseases	0.5%
971	Vertebrobasilar Insufficiency	0.5%
972	Anterior Spinal Artery Syndrome	0.5%
973	Basilar Artery Stenosis	0.5%
974	Vertebral Artery Stenosis	0.5%
975	Sleep Apnea, Obstructive	0.5%
976	Sleep Apnea, Central	0.5%
977	Intracranial Hemorrhage, Hypertensive	0.5%
978	Transient Cerebral Ischemia	0.5%
979	Phantom pain	0.5%
980	Phantom Limb Pain	0.5%
981	Lyme Neuroborreliosis	0.5%
982	Narcolepsy	0.5%
983	Radicular Cyst	0.5%
984	Trigeminal Neuralgia	0.5%
985	Kleine-Levin Syndrome	0.5%
986	Agraphia	0.5%
987	Anomia	0.5%
988	Cluttering	0.5%
989	Language Development Disorders	0.5%
990	Speech Disorders	0.5%
991	Syncope	0.5%
992	Stupor	0.5%
993	Dysgraphia	0.5%
994	Presyncope	0.5%
995	Dyslalia	0.5%
996	Hematoma, Subdural, Intracranial	0.5%
997	Hematoma, Subdural, Chronic	0.5%
998	Hematoma, Subdural, Acute	0.5%
999	Lateral Medullary Syndrome	0.5%
1000	Cluster Headache	0.5%
1001	Migraine with Aura	0.5%
1002	Familial Hemiplegic Migraine	0.5%
1003	Chronic Paroxysmal Hemicrania	0.5%
1004	SUNCT Syndrome	0.5%
1005	Paroxysmal Hemicrania	0.5%
1006	Eye Burns	0.5%
1007	Malaria, Cerebral	0.5%
1008	Carotid Stenosis	0.5%
1009	Intracranial Aneurysm	0.5%
1010	Neurocysticercosis	0.5%
1011	Amaurosis Fugax	0.5%
1012	Blindness, Cortical	0.5%
1013	Dyscalculia	0.5%
1014	Intracranial Arteriosclerosis	0.5%
1015	Cerebral Atherosclerosis	0.5%
1016	Subarachnoid Hemorrhage	0.5%
1017	Cerebral Arteriosclerosis	0.5%
1018	Cerebral Hemorrhage	0.5%
1019	Cerebral Thrombosis	0.5%
1020	Intracranial Embolism	0.5%
1021	Intracranial Thrombosis	0.5%
1022	Deafness	0.5%
1023	Hearing Loss, Sudden	0.5%
1024	Gerstmann Syndrome	0.5%
1025	Hearing Loss, Bilateral	0.5%
1026	Hearing Loss, High-Frequency	0.5%
1027	Hearing Loss, Mixed Conductive-Sensorineural	0.5%
1028	Prosopagnosia	0.5%
1029	Apraxia, Ideomotor	0.5%
1030	Charles Bonnet Syndrome	0.5%
1031	Hearing Loss, Unilateral	0.5%
1032	Complete Hearing Loss	0.5%
1033	Alien Hand Syndrome	0.5%
1034	Deaf Mutism	0.5%
1035	Waterhouse-Friderichsen Syndrome	0.4%
1036	Corneal Scar	0.4%
1037	Hyperprolactinemia	0.4%
1038	Retrograde amnesia	0.4%
1039	Amnesia, Anterograde	0.4%
1040	Carotid Artery Thrombosis	0.4%
1041	Subclavian Steal Syndrome	0.4%
1042	Pick Disease of the Brain	0.4%
1043	Cataplexy	0.4%
1044	Aphasia	0.4%
1045	Articulation Disorders	0.4%
1046	Echolalia	0.4%
1047	Stuttering	0.4%
1048	Dysphasia	0.4%
1049	Mutism	0.4%
1050	Selective Mutism	0.4%
1051	Cerebral Amyloid Angiopathy	0.3%
1052	Sinus Thrombosis, Intracranial	0.3%
1053	Dysarthria	0.3%
1054	Corneal Perforation	0.3%
1055	Alexia, Pure	0.3%
1056	Cavernous Sinus Thrombosis	0.3%
1057	Sagittal Sinus Thrombosis	0.3%
1058	Prolactinoma	0.3%
1059	Growth Hormone-Secreting Pituitary Adenoma	0.3%
1060	Nelson Syndrome	0.3%

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