MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Aortic Valve Prolapse

(UMLS:C0003505)

Definition:: The downward displacement of the cuspal or pointed end of the trileaflet AORTIC VALVE causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to aortic regurgitation.
UMLS ID:: C0003505
MeSH ID:: D001023

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.484.400.100

Synonym(s)

Aortic Valve Prolapse

Aortic valve prolapse

aortic valve prolapse

prolapse aortic valve

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Ciprofloxacin	FAERS: 2	US FAERS
2	Cabergoline	FAERS: 1	US FAERS
3	Citalopram	FAERS: 1	US FAERS
4	Paroxetine	FAERS: 1	US FAERS
5	Paroxetine	Canada Vigilance: 1	Canada Vigilance
6	tegaserod		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Tricuspid Valve Prolapse	48.4%
2	Aortic Valve Insufficiency	34.4%
3	Mitral Valve Insufficiency	34.4%
4	Mitral Valve Stenosis	34.4%
5	Pulmonary Valve Insufficiency	34.4%
6	Tricuspid Valve Insufficiency	34.4%
7	Tricuspid Valve Stenosis	34.4%
8	Aortic Valve Stenosis	33%
9	Pulmonary Valve Stenosis	33%
10	Cardiac Tamponade	25.4%
11	Endocarditis	25.4%
12	Cardiac Arrest	25.4%
13	Heart failure	25.4%
14	Pericardial effusion	25.4%
15	Pericarditis	25.4%
16	Pneumopericardium	25.4%
17	Cor pulmonale	25.4%
18	Ventricular Outflow Obstruction	25.4%
19	Ventricular Dysfunction	25.4%
20	Cardiomyopathies	25.4%
21	Pleuropericarditis	25.4%
22	Myocardial Ischemia	23%
23	Tricuspid Atresia	21.7%
24	Supravalvular aortic stenosis	21.5%
25	Hypertrophic Cardiomyopathy	21.1%
26	Hypertrophic obstructive cardiomyopathy	21.1%
27	Cardiomyopathy, Dilated	19.8%
28	Cardiac Output, High	17.2%
29	Myocardial Stunning	17.2%
30	Low Cardiac Output Syndrome	17.2%
31	Cardiomegaly	16.9%
32	Postpericardiotomy Syndrome	16.9%
33	Cardiac Hypertrophy	16.9%
34	Rheumatic Heart Disease	16.6%
35	Vascular Diseases	16.4%
36	Heart Block	14.9%
37	Tachycardia	14.9%
38	Tachyarrhythmia	14.9%
39	Restrictive cardiomyopathy	14.8%
40	Endocardial Fibroelastosis	14.8%
41	Heart Rupture, Post-Infarction	14.8%
42	Myocarditis	14.8%
43	Pericarditis, Constrictive	14.8%
44	Ventricular Dysfunction, Left	14.8%
45	Right Ventricular Dysfunction	14.8%
46	Endomyocardial Fibrosis	14.8%
47	Carditis	14.8%
48	Heart Failure, Systolic	14.8%
49	Heart Failure, Diastolic	14.8%
50	Arrhythmogenic Right Ventricular Dysplasia	13.8%
51	Coronary heart disease	13.2%
52	Myocardial Infarction	13.2%
53	Myocardial Reperfusion Injury	13.2%
54	Acute Coronary Syndrome	13.2%
55	Lown-Ganong-Levine Syndrome	12.9%
56	Long QT Syndrome	11.8%
57	Pregnancy Complications, Cardiovascular	10.8%
58	Cardiovascular Abnormalities	10.8%
59	Kounis Syndrome	10.1%
60	Sinus Arrhythmia	9.9%
61	Atrial Fibrillation	9.9%
62	Atrial Flutter	9.9%
63	Edema, Cardiac	9.9%
64	Ventricular Fibrillation	9.9%
65	Ventricular Flutter	9.9%
66	Parasystole	9.9%
67	Paroxysmal atrial fibrillation	9.9%
68	Bradycardia	9.9%
69	Diabetic Cardiomyopathies	9.9%
70	Aortic coarctation	9.8%
71	Cor Triatriatum	9.8%
72	Coronary Vessel Anomalies	9.8%
73	Patent ductus arteriosus	9.8%
74	Ebstein Anomaly	9.8%
75	Heart Septal Defects	9.8%
76	Tetralogy of Fallot	9.8%
77	Transposition of Great Vessels	9.8%
78	Hypoplastic Left Heart Syndrome	9.8%
79	Angina Pectoris	9.8%
80	Cardiomyopathy, Alcoholic	9.8%
81	Sudden Cardiac Death	9.8%
82	Left Ventricular Hypertrophy	9.8%
83	Right Ventricular Hypertrophy	9.8%
84	Chagas Cardiomyopathy	9.7%
85	Carcinoid Heart Disease	9.7%
86	Adams-Stokes Syndrome	9.7%
87	Atrioventricular Block	9.7%
88	Bundle-Branch Block	9.7%
89	Atrial Premature Complexes	9.7%
90	Sick Sinus Syndrome	9.7%
91	Sinoatrial Block	9.7%
92	Tachycardia, Paroxysmal	9.7%
93	Supraventricular tachycardia	9.7%
94	Tachycardia, Ventricular	9.7%
95	Wolff-Parkinson-White Syndrome	9.7%
96	Tachycardia, Reciprocating	9.7%
97	Takotsubo Cardiomyopathy	9.7%
98	Bacterial Endocarditis	9.5%
99	Coronary Aneurysm	8.9%
100	Coronary Occlusion	8.6%
101	Microvascular Angina	8.6%
102	Coronary Stenosis	8.6%
103	ST segment elevation myocardial infarction	8.6%
104	Aneurysm	8.5%
105	Angiomatosis	8.5%
106	Aortic Diseases	8.5%
107	Arterial Occlusive Diseases	8.5%
108	Hyperemia	8.5%
109	Hypotension	8.5%
110	Superior Vena Cava Syndrome	8.5%
111	Telangiectasis	8.5%
112	Vasculitis	8.5%
113	Venous Insufficiency	8.5%
114	Peripheral Vascular Diseases	8.5%
115	Embolism and Thrombosis	8.5%
116	Angiodysplasia	8.5%
117	Capillary Leak Syndrome	8.5%
118	Prehypertension	8.5%
119	Coronary Thrombosis	8.1%
120	Coronary Artery Disease	8.1%
121	Dextrocardia	7.9%
122	Romano-Ward Syndrome	7.7%
123	Dyspnea, Paroxysmal	7.4%
124	Tachycardia, Atrioventricular Nodal Reentry	7.2%
125	Tachycardia, Ectopic Atrial	7.2%
126	Tachycardia, Ectopic Junctional	7.2%
127	Sinus Tachycardia	7.2%
128	Torsades de Pointes	7.2%
129	Accelerated Idioventricular Rhythm	7.2%
130	Williams Syndrome	6.8%
131	Aortic Aneurysm	6.6%
132	Aortitis	6.6%
133	Leriche Syndrome	6.6%
134	Periphlebitis	6.6%
135	Phlebitis	6.6%
136	Thromboangiitis Obliterans	6.6%
137	Shock, Cardiogenic	6.5%
138	Sinus Arrest, Cardiac	6.5%
139	Aortopulmonary Septal Defect	6.4%
140	Double Outlet Right Ventricle	6.4%
141	Endocardial Cushion Defects	6.4%
142	Myocardial bridging	6.4%
143	Aorticopulmonary Septal Defect	6.4%
144	Angina, Unstable	6.4%
145	Coronary Restenosis	6.4%
146	Vascular System Injuries	6%
147	Embolism, Amniotic Fluid	5.8%
148	Compartment syndromes	5.7%
149	Hepatic Veno-Occlusive Disease	5.7%
150	Peliosis Hepatis	5.7%
151	Varicocele	5.7%
152	Noonan Syndrome	5.7%
153	Cerebrovascular Disorders	5.6%
154	Diabetic Angiopathies	5.6%
155	Reperfusion Injury	5.6%
156	Splenic Infarction	5.6%
157	Cerebrovascular Insufficiency	5.6%
158	Vascular Neoplasms	5.6%
159	Spinal Cord Vascular Diseases	5.6%
160	Vasoplegia	5.6%
161	Hemorrhoids	5.6%
162	Thoracic Outlet Syndrome	5.6%
163	Retinal Vein Occlusion	5.5%
164	Postphlebitic Syndrome	5.4%
165	Marfan Syndrome	5%
166	Malignant Atrophic Papulosis	5%
167	Aneurysm, Dissecting	4.9%
168	Arteriosclerosis	4.9%
169	Arteritis	4.9%
170	Embolism	4.9%
171	Erythromelalgia	4.9%
172	Fibromuscular Dysplasia	4.9%
173	Malignant Hypertension	4.9%
174	Raynaud Disease	4.9%
175	Shwartzman Phenomenon	4.9%
176	Thromboembolism	4.9%
177	Thrombosis	4.9%
178	Essential Hypertension	4.9%
179	Aneurysm, Ruptured	4.9%
180	Iliac Aneurysm	4.9%
181	Pulmonary artery stenosis	4.9%
182	White Coat Hypertension	4.9%
183	Systemic Vasculitis	4.9%
184	Embolus	4.9%
185	May-Thurner Syndrome	4.9%
186	Subacute Bacterial Endocarditis	4.9%
187	Truncus Arteriosus, Persistent	4.8%
188	Angina Pectoris, Variant	4.8%
189	Arteriovenous fistula	4.6%
190	Blue Toe Syndrome	4.6%
191	Hand-Arm Vibration Syndrome	4.4%
192	Thrombophlebitis	4.4%
193	Aortic Aneurysm, Abdominal	4.3%
194	Aortic Aneurysm, Thoracic	4.3%
195	Optic Neuropathy, Ischemic	4.3%
196	Anterior Ischemic Optic Neuropathy	4.3%
197	Mesenteric vascular insufficiency	4.3%
198	Angioedema	4.1%
199	Colitis, Ischemic	4.1%
200	Intracranial Embolism and Thrombosis	4.1%
201	Carotid Stenosis	4%
202	Intracranial Aneurysm	4%
203	Aortic Rupture	3.9%
204	Scimitar Syndrome	3.9%
205	Carotid Artery Thrombosis	3.5%
206	Moyamoya Disease	3.5%
207	Retinal Artery Occlusion	3.4%
208	Retinal Vasculitis	3.4%
209	Hypertensive Retinopathy	3.4%
210	Vasculitis, Central Nervous System	3.3%
211	Anterior Compartment Syndrome	3.3%
212	Vasculitis, Leukocytoclastic, Cutaneous	3.3%
213	Gastric Antral Vascular Ectasia	3.3%
214	Abdominal Compartment Syndrome	3.3%
215	Carotid Artery Diseases	3.3%
216	Brain Ischemia	3.3%
217	Ectopia Cordis	3.3%
218	Hypotension, Orthostatic	3.3%
219	Cerebrovascular accident	3.3%
220	Varicose Ulcer	3.3%
221	Vasospasm, Intracranial	3.3%
222	Spinal Cord Ischemia	3.3%
223	Intracranial Arterial Diseases	3.3%
224	Primary Graft Dysfunction	3.3%
225	Single umbilical artery	3.3%
226	Post-Exercise Hypotension	3.3%
227	Polyarteritis Nodosa	3.3%
228	Takayasu Arteritis	3.3%
229	Arteriosclerosis Obliterans	3.2%
230	Atherosclerosis	3.2%
231	Air Embolism	3.2%
232	Endarteritis	3.2%
233	Venous Thrombosis	3.2%
234	Deep Vein Thrombosis	3.2%
235	Venous Thromboembolism	3.2%
236	Intracranial Arteriosclerosis	3.2%
237	Cerebral Atherosclerosis	3.2%
238	Cerebral Arteriosclerosis	3.2%
239	Cerebral Thrombosis	2.8%
240	Intracranial Embolism	2.8%
241	Intracranial Thrombosis	2.8%
242	Turner Syndrome	2.8%
243	Kearns-Sayre syndrome	2.6%
244	Brain Infarction	2.6%
245	Mesenteric Vascular Occlusion	2.5%
246	Mucocutaneous Lymph Node Syndrome	2.5%
247	Diabetic Retinopathy	2.5%
248	Sturge-Weber Syndrome	2.5%
249	Livedo Reticularis	2.5%
250	Renal hypertension	2.5%
251	Renal Artery Obstruction	2.5%
252	Renal Artery Stenosis	2.5%
253	Hemangioma, Cavernous	2.4%
254	Basal Ganglia Cerebrovascular Disease	2.4%
255	Giant Cell Arteritis	2.4%
256	Temporal Arteritis	2.4%
257	Vascular Headaches	2.4%
258	Scurvy	2.4%
259	CREST Syndrome	2.3%
260	Intermittent Claudication	2.2%
261	Pulmonary Embolism	2.2%
262	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2.2%
263	Sinus Thrombosis, Intracranial	2.2%
264	No-Reflow Phenomenon	2.2%
265	Vertebral Artery Dissection	2.2%
266	Cerebral Arterial Diseases	2.1%
267	Vertebrobasilar Insufficiency	2.1%
268	Anterior Spinal Artery Syndrome	2.1%
269	Basilar Artery Stenosis	2.1%
270	Vertebral Artery Stenosis	2.1%
271	Intracranial Hemorrhage, Hypertensive	2.1%
272	Transient Cerebral Ischemia	2.1%
273	Kartagener Syndrome	2.1%
274	Dural Arteriovenous Fistula	2%
275	Subarachnoid Hemorrhage, Traumatic	2%
276	Carotid Artery, Internal, Dissection	2%
277	Lemierre Syndrome	2%
278	Ischemic contracture	2%
279	Angioedemas, Hereditary	2%
280	Cryoglobulinemia	2%
281	Leukomalacia, Periventricular	2%
282	Diabetic Foot	1.9%
283	Cerebral Infarction	1.9%
284	Brain Stem Infarctions	1.9%
285	Cavernous Sinus Thrombosis	1.9%
286	Sagittal Sinus Thrombosis	1.9%
287	Carotid Artery Injuries	1.9%
288	Infarction, Middle Cerebral Artery	1.8%
289	Infarction, Anterior Cerebral Artery	1.8%
290	Infarction, Posterior Cerebral Artery	1.8%
291	Hepatic Vein Thrombosis	1.7%
292	Budd-Chiari Syndrome	1.7%
293	Shy-Drager Syndrome	1.6%
294	Pulmonary Infarction	1.6%
295	Purpura, Hyperglobulinemic	1.6%
296	Hypertension, Renovascular	1.6%
297	Subarachnoid Hemorrhage	1.6%
298	Hypoxia-Ischemia, Brain	1.6%
299	Cerebral Hemorrhage	1.6%
300	Hereditary Angioedema Type III	1.6%
301	Hereditary Angioedema Types I and II	1.6%
302	Basal Ganglia Hemorrhage	1.6%
303	Subclavian Steal Syndrome	1.6%
304	Lateral Medullary Syndrome	1.6%
305	Behcet Syndrome	1.4%
306	Waldenstrom Macroglobulinemia	1.4%
307	Multiple Myeloma	1.4%
308	Pituitary Apoplexy	1.3%
309	Ataxia Telangiectasia	1.3%
310	Pseudoxanthoma Elasticum	1.3%
311	Putaminal Hemorrhage	1.2%
312	Granulomatosis with polyangiitis	1.2%
313	Dementia, Vascular	1.2%
314	Cerebral Amyloid Angiopathy	1.2%
315	Rheumatoid Vasculitis	1.1%
316	Lupus Vasculitis, Central Nervous System	1.1%
317	Hematoma, Subdural	0.7%
318	Hematoma, Epidural, Cranial	0.7%
319	MELAS Syndrome	0.6%
320	Brain Hemorrhage, Traumatic	0.6%
321	Hematoma, Subdural, Intracranial	0.6%
322	Hematoma, Subdural, Chronic	0.6%
323	Hematoma, Subdural, Acute	0.6%
324	Fabry Disease	0.5%

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