MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Endocardial Fibroelastosis

(UMLS:C0014117)

Definition:: A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.
UMLS ID:: C0014117
MeSH ID:: D004695

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.238.281

Synonym(s)

Endocardial Fibroelastosis

EFE - Endocardial fibroelastosis

ENDOCARDIAL FIBROELASTOSIS

Elastomyofibrosis

Endocardial fibroelastosis

elastomyofibrosis

endocardial fibroelastosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Adzenys XR-ODT	FAERS: 1		US FAERS
2	Alprazolam	FAERS: 1		US FAERS
3	Dexamethasone	FAERS: 1		US FAERS
4	Fluoxetine	FAERS: 1		US FAERS
5	Prednisolone	FAERS: 1		US FAERS
6	Ritonavir	FAERS: 1		US FAERS
7	Theophylline	FAERS: 1		US FAERS
8	dolutegravir	FAERS: 1		US FAERS
9	Doxorubicin		6612319	CTD
10	Ritodrine		3681864	CTD
11	Sulfate			OFFSIDES
12	Terbutaline			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Restrictive cardiomyopathy	46.7%
2	Myocarditis	46.7%
3	Endomyocardial Fibrosis	46.7%
4	Carditis	46.7%
5	Cardiomyopathy, Dilated	44.4%
6	Hypertrophic Cardiomyopathy	38.8%
7	Hypertrophic obstructive cardiomyopathy	38.8%
8	Diabetic Cardiomyopathies	31.1%
9	Cardiac Tamponade	31%
10	Endocarditis	31%
11	Cardiac Arrest	31%
12	Heart failure	31%
13	Pericardial effusion	31%
14	Pericarditis	31%
15	Pneumopericardium	31%
16	Cor pulmonale	31%
17	Ventricular Outflow Obstruction	31%
18	Ventricular Dysfunction	31%
19	Pleuropericarditis	31%
20	Cardiomyopathy, Alcoholic	30.8%
21	Chagas Cardiomyopathy	30.6%
22	Arrhythmogenic Right Ventricular Dysplasia	29.1%
23	Myocardial Ischemia	27.9%
24	Aortic Valve Stenosis	26.7%
25	Pulmonary Valve Stenosis	26.7%
26	Myocardial Reperfusion Injury	26.5%
27	Cardiac Output, High	20.9%
28	Myocardial Stunning	20.9%
29	Low Cardiac Output Syndrome	20.9%
30	Cardiomegaly	20.5%
31	Postpericardiotomy Syndrome	20.5%
32	Cardiac Hypertrophy	20.5%
33	Rheumatic Heart Disease	20.1%
34	Aortic Valve Insufficiency	20%
35	Heart Block	20%
36	Heart Rupture, Post-Infarction	20%
37	Mitral Valve Insufficiency	20%
38	Mitral Valve Stenosis	20%
39	Pericarditis, Constrictive	20%
40	Pulmonary Valve Insufficiency	20%
41	Tachycardia	20%
42	Tricuspid Valve Insufficiency	20%
43	Tricuspid Valve Stenosis	20%
44	Tachyarrhythmia	20%
45	Ventricular Dysfunction, Left	20%
46	Right Ventricular Dysfunction	20%
47	Heart Failure, Systolic	20%
48	Heart Failure, Diastolic	20%
49	Supravalvular aortic stenosis	19.6%
50	Lown-Ganong-Levine Syndrome	19.6%
51	Tricuspid Atresia	18.5%
52	Vascular Diseases	18.5%
53	Coronary heart disease	17.8%
54	Myocardial Infarction	17.8%
55	Acute Coronary Syndrome	17.8%
56	Long QT Syndrome	15.9%
57	Aortic Valve Prolapse	14.8%
58	Tricuspid Valve Prolapse	14.8%
59	Takotsubo Cardiomyopathy	14.8%
60	Adams-Stokes Syndrome	14.6%
61	Atrioventricular Block	14.6%
62	Bundle-Branch Block	14.6%
63	Atrial Premature Complexes	14.6%
64	Sinoatrial Block	14.6%
65	Tachycardia, Paroxysmal	14.6%
66	Supraventricular tachycardia	14.6%
67	Tachycardia, Ventricular	14.6%
68	Wolff-Parkinson-White Syndrome	14.6%
69	Tachycardia, Reciprocating	14.6%
70	Sick Sinus Syndrome	14.6%
71	Kounis Syndrome	13.6%
72	Sinus Arrhythmia	13.3%
73	Atrial Fibrillation	13.3%
74	Atrial Flutter	13.3%
75	Edema, Cardiac	13.3%
76	Ventricular Fibrillation	13.3%
77	Ventricular Flutter	13.3%
78	Parasystole	13.3%
79	Paroxysmal atrial fibrillation	13.3%
80	Bradycardia	13.3%
81	Aortic coarctation	13.2%
82	Cor Triatriatum	13.2%
83	Coronary Vessel Anomalies	13.2%
84	Patent ductus arteriosus	13.2%
85	Ebstein Anomaly	13.2%
86	Heart Septal Defects	13.2%
87	Tetralogy of Fallot	13.2%
88	Transposition of Great Vessels	13.2%
89	Hypoplastic Left Heart Syndrome	13.2%
90	Sudden Cardiac Death	13.2%
91	Left Ventricular Hypertrophy	13.2%
92	Right Ventricular Hypertrophy	13.2%
93	Angina Pectoris	13.2%
94	Coronary Aneurysm	13.1%
95	Coronary Occlusion	13%
96	Microvascular Angina	13%
97	Coronary Stenosis	13%
98	ST segment elevation myocardial infarction	13%
99	Bacterial Endocarditis	12.3%
100	Coronary Thrombosis	12.2%
101	Pregnancy Complications, Cardiovascular	12.2%
102	Cardiovascular Abnormalities	12.2%
103	Coronary Artery Disease	12.2%
104	Tachycardia, Atrioventricular Nodal Reentry	12%
105	Tachycardia, Ectopic Atrial	12%
106	Tachycardia, Ectopic Junctional	12%
107	Sinus Tachycardia	12%
108	Torsades de Pointes	12%
109	Accelerated Idioventricular Rhythm	12%
110	Carcinoid Heart Disease	11.7%
111	Romano-Ward Syndrome	11.7%
112	Coronary Restenosis	10.8%
113	Dextrocardia	10.6%
114	Aneurysm	10.3%
115	Angiomatosis	10.3%
116	Aortic Diseases	10.3%
117	Arterial Occlusive Diseases	10.3%
118	Hyperemia	10.3%
119	Hypotension	10.3%
120	Superior Vena Cava Syndrome	10.3%
121	Telangiectasis	10.3%
122	Vasculitis	10.3%
123	Venous Insufficiency	10.3%
124	Peripheral Vascular Diseases	10.3%
125	Embolism and Thrombosis	10.3%
126	Angiodysplasia	10.3%
127	Capillary Leak Syndrome	10.3%
128	Prehypertension	10.3%
129	Dyspnea, Paroxysmal	9.9%
130	Shock, Cardiogenic	9.8%
131	Sinus Arrest, Cardiac	9.8%
132	Aortopulmonary Septal Defect	9.7%
133	Double Outlet Right Ventricle	9.7%
134	Endocardial Cushion Defects	9.7%
135	Myocardial bridging	9.7%
136	Aorticopulmonary Septal Defect	9.7%
137	Angina, Unstable	9.7%
138	Aortic Aneurysm	8.9%
139	Aortitis	8.9%
140	Leriche Syndrome	8.9%
141	Periphlebitis	8.9%
142	Phlebitis	8.9%
143	Thromboangiitis Obliterans	8.9%
144	Kearns-Sayre syndrome	8.2%
145	Truncus Arteriosus, Persistent	8%
146	Angina Pectoris, Variant	8%
147	Postphlebitic Syndrome	7.7%
148	Noonan Syndrome	7.6%
149	Embolism, Amniotic Fluid	7.6%
150	Vascular System Injuries	7.3%
151	Retinal Vein Occlusion	7.2%
152	Subacute Bacterial Endocarditis	7.1%
153	Compartment syndromes	7%
154	Hepatic Veno-Occlusive Disease	7%
155	Peliosis Hepatis	7%
156	Varicocele	7%
157	Thrombophlebitis	6.9%
158	Cerebrovascular Disorders	6.8%
159	Diabetic Angiopathies	6.8%
160	Reperfusion Injury	6.8%
161	Splenic Infarction	6.8%
162	Cerebrovascular Insufficiency	6.8%
163	Vascular Neoplasms	6.8%
164	Spinal Cord Vascular Diseases	6.8%
165	Vasoplegia	6.8%
166	Blue Toe Syndrome	6.8%
167	Marfan Syndrome	6.8%
168	Hemorrhoids	6.7%
169	Thoracic Outlet Syndrome	6.7%
170	Aneurysm, Dissecting	6.7%
171	Arteriosclerosis	6.7%
172	Arteritis	6.7%
173	Embolism	6.7%
174	Erythromelalgia	6.7%
175	Fibromuscular Dysplasia	6.7%
176	Malignant Hypertension	6.7%
177	Raynaud Disease	6.7%
178	Thromboembolism	6.7%
179	Thrombosis	6.7%
180	Essential Hypertension	6.7%
181	Aneurysm, Ruptured	6.7%
182	Iliac Aneurysm	6.7%
183	Malignant Atrophic Papulosis	6.7%
184	Pulmonary artery stenosis	6.7%
185	White Coat Hypertension	6.7%
186	Systemic Vasculitis	6.7%
187	Embolus	6.7%
188	Shwartzman Phenomenon	6.6%
189	May-Thurner Syndrome	6.6%
190	Arteriovenous fistula	6.5%
191	Aortic Aneurysm, Abdominal	6.5%
192	Aortic Aneurysm, Thoracic	6.5%
193	Aortic Rupture	6%
194	Intracranial Embolism and Thrombosis	5.7%
195	Carotid Stenosis	5.7%
196	Intracranial Aneurysm	5.7%
197	Carotid Artery Thrombosis	5.5%
198	Hand-Arm Vibration Syndrome	5.4%
199	Optic Neuropathy, Ischemic	5.2%
200	Anterior Ischemic Optic Neuropathy	5.2%
201	Mesenteric vascular insufficiency	5.2%
202	Moyamoya Disease	5.1%
203	Angioedema	5%
204	Colitis, Ischemic	5%
205	Arteriosclerosis Obliterans	4.9%
206	Atherosclerosis	4.9%
207	Air Embolism	4.9%
208	Endarteritis	4.9%
209	Polyarteritis Nodosa	4.9%
210	Takayasu Arteritis	4.9%
211	Venous Thrombosis	4.9%
212	Deep Vein Thrombosis	4.9%
213	Williams Syndrome	4.9%
214	Venous Thromboembolism	4.9%
215	Scimitar Syndrome	4.9%
216	Intracranial Arteriosclerosis	4.9%
217	Cerebral Atherosclerosis	4.9%
218	Cerebral Arteriosclerosis	4.9%
219	Retinal Artery Occlusion	4.5%
220	Retinal Vasculitis	4.5%
221	Hypertensive Retinopathy	4.5%
222	Vasculitis, Central Nervous System	4.5%
223	Anterior Compartment Syndrome	4.4%
224	Vasculitis, Leukocytoclastic, Cutaneous	4.4%
225	Gastric Antral Vascular Ectasia	4.4%
226	Abdominal Compartment Syndrome	4.4%
227	Cerebral Thrombosis	4.4%
228	Intracranial Embolism	4.4%
229	Intracranial Thrombosis	4.4%
230	Carotid Artery Diseases	4.4%
231	Brain Ischemia	4.4%
232	Ectopia Cordis	4.4%
233	Hypotension, Orthostatic	4.4%
234	Cerebrovascular accident	4.4%
235	Varicose Ulcer	4.4%
236	Vasospasm, Intracranial	4.4%
237	Spinal Cord Ischemia	4.4%
238	Intracranial Arterial Diseases	4.4%
239	Primary Graft Dysfunction	4.4%
240	Single umbilical artery	4.4%
241	Post-Exercise Hypotension	4.4%
242	Brain Infarction	3.9%
243	Sinus Thrombosis, Intracranial	3.8%
244	Turner Syndrome	3.7%
245	Giant Cell Arteritis	3.7%
246	Temporal Arteritis	3.7%
247	Cavernous Sinus Thrombosis	3.5%
248	Sagittal Sinus Thrombosis	3.5%
249	Lemierre Syndrome	3.4%
250	Mesenteric Vascular Occlusion	3.4%
251	Mucocutaneous Lymph Node Syndrome	3.4%
252	Intermittent Claudication	3.4%
253	Pulmonary Embolism	3.4%
254	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.4%
255	Diabetic Retinopathy	3.4%
256	Sturge-Weber Syndrome	3.4%
257	Livedo Reticularis	3.3%
258	Renal hypertension	3.3%
259	Renal Artery Obstruction	3.3%
260	Renal Artery Stenosis	3.3%
261	No-Reflow Phenomenon	3.3%
262	Hemangioma, Cavernous	3.3%
263	Basal Ganglia Cerebrovascular Disease	3.3%
264	Vertebral Artery Dissection	3.3%
265	Vascular Headaches	3.3%
266	Scurvy	3.3%
267	CREST Syndrome	3.2%
268	Cerebral Arterial Diseases	3.2%
269	Vertebrobasilar Insufficiency	3.2%
270	Anterior Spinal Artery Syndrome	3.2%
271	Basilar Artery Stenosis	3.2%
272	Vertebral Artery Stenosis	3.2%
273	Intracranial Hemorrhage, Hypertensive	3.2%
274	Transient Cerebral Ischemia	3.2%
275	Subarachnoid Hemorrhage, Traumatic	3.2%
276	Carotid Artery, Internal, Dissection	3.2%
277	Cerebral Infarction	3.2%
278	Brain Stem Infarctions	3.2%
279	Infarction, Middle Cerebral Artery	3.2%
280	Infarction, Anterior Cerebral Artery	3.2%
281	Infarction, Posterior Cerebral Artery	3.2%
282	Kartagener Syndrome	3.1%
283	Lateral Medullary Syndrome	2.9%
284	Hepatic Vein Thrombosis	2.8%
285	Budd-Chiari Syndrome	2.8%
286	Carotid Artery Injuries	2.8%
287	Pulmonary Infarction	2.7%
288	Dural Arteriovenous Fistula	2.7%
289	Subclavian Steal Syndrome	2.7%
290	Ischemic contracture	2.7%
291	Angioedemas, Hereditary	2.6%
292	Cryoglobulinemia	2.6%
293	Leukomalacia, Periventricular	2.6%
294	Diabetic Foot	2.6%
295	Basal Ganglia Hemorrhage	2.5%
296	Hypertension, Renovascular	2.4%
297	Subarachnoid Hemorrhage	2.4%
298	Hypoxia-Ischemia, Brain	2.4%
299	Cerebral Hemorrhage	2.4%
300	Hereditary Angioedema Type III	2.4%
301	Hereditary Angioedema Types I and II	2.4%
302	Shy-Drager Syndrome	2.2%
303	Purpura, Hyperglobulinemic	2.2%
304	Putaminal Hemorrhage	2.2%
305	Granulomatosis with polyangiitis	2.1%
306	Dementia, Vascular	2%
307	Cerebral Amyloid Angiopathy	2%
308	Pituitary Apoplexy	2%
309	Behcet Syndrome	1.9%
310	Waldenstrom Macroglobulinemia	1.9%
311	Multiple Myeloma	1.9%
312	Ataxia Telangiectasia	1.7%
313	Pseudoxanthoma Elasticum	1.7%
314	Rheumatoid Vasculitis	1.6%
315	Lupus Vasculitis, Central Nervous System	1.6%
316	Hematoma, Subdural	1.2%
317	Hematoma, Epidural, Cranial	1.2%
318	Hematoma, Subdural, Intracranial	1%
319	Hematoma, Subdural, Chronic	1%
320	Hematoma, Subdural, Acute	1%
321	Brain Hemorrhage, Traumatic	1%
322	MELAS Syndrome	1%
323	Fabry Disease	0.7%

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