MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Folic Acid Deficiency

(UMLS:C0016412)

Definition:: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
UMLS ID:: C0016412
MeSH ID:: D005494

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.699.308

Synonym(s)

Folic Acid Deficiency

Deficiency of folic acid

Deficiency;vitamin;folate

FOLATE DEFICIENCY

Folate deficiency

Folic acid deficiency

Folic acid deficiency disease

Reduced blood folate concentration

Vitamin B9 deficiency

10.

acid deficiency folic

11.

acid folic deficiency

12.

deficiency folate

13.

deficiency; folate

14.

deficiency; folic acid

15.

folate deficiency

16.

folate; deficiency

17.

folic acid deficiency

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Codeine	17488670	CTD
2	Cyproterone	9169341	CTD
3	Dextromethorphan	17488670	CTD
4	Folic Acid	5359954 5694067 30153273	CTD
5	Hydroxyurea	5120187	CTD
6	Methyldopa	5694067	CTD
7	Norinyl	9169341	CTD
8	Phenobarbital	4627864	CTD
9	Phenytoin	4175396 4627864	CTD
10	Primidone	2535199 4627864	CTD
11	S-Adenosylmethionine	7527320	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Pellagra	49.6%
2	Thiamine Deficiency	49.6%
3	Vitamin B 12 Deficiency	49.6%
4	Vitamin B 6 Deficiency	49.6%
5	Pyridoxine Deficiency	49.6%
6	Beriberi	37.1%
7	Ascorbic Acid Deficiency	36.8%
8	Vitamin A Deficiency	36.8%
9	Vitamin D Deficiency	36.8%
10	Vitamin E Deficiency	36.8%
11	Magnesium Deficiency	29.9%
12	Potassium Deficiency	29.9%
13	Protein Deficiency	29.9%
14	Starvation	25.5%
15	Refeeding Syndrome	25.5%
16	Anemia, Pernicious	24.8%
17	Hyperhomocysteinemia	22.5%
18	Child Nutrition Disorders	21.3%
19	Hypervitaminosis A	21.3%
20	Infant Nutrition Disorders	21.3%
21	Wasting Syndrome	19.4%
22	Vitamin K Deficiency	18.9%
23	Marasmus	17.8%
24	Metabolic Diseases	14.8%
25	Wernicke Encephalopathy	14%
26	Kwashiorkor	13.9%
27	Subacute Combined Degeneration	13.2%
28	Rickets	13%
29	Scurvy	12.4%
30	Osteomalacia	9%
31	Acid-Base Imbalance	7.1%
32	Calcium Metabolism Disorders	7.1%
33	Iron Metabolism Disorders	7.1%
34	Phosphorus Metabolism Disorders	7.1%
35	Water-Electrolyte Imbalance	7.1%
36	Lipid Metabolism Disorders	7.1%
37	Mitochondrial Diseases	7.1%
38	Glucose Metabolism Disorders	7.1%
39	Renal Osteodystrophy	5.7%
40	Renal rickets	5.7%
41	Hypercalcemia	4.9%
42	Hypocalcemia	4.9%
43	Milk-Alkali Syndrome	4.9%
44	HIV Wasting Syndrome	4.9%
45	Osteopenia	4.8%
46	Brain Diseases, Metabolic	4.7%
47	Obesity	4.3%
48	Lipodystrophy	3.7%
49	Acidosis	3.6%
50	Alkalosis	3.6%
51	Amyloidosis	3.6%
52	Calcinosis	3.6%
53	Hyperglycemia	3.6%
54	Hyperinsulinism	3.6%
55	Hyperkalemia	3.6%
56	Hypernatremia	3.6%
57	Hypoglycemia	3.6%
58	Hypokalemia	3.6%
59	Hyponatremia	3.6%
60	Xanthomatosis	3.6%
61	Hypophosphatemia	3.6%
62	Metabolic acidosis	3.6%
63	Dyslipidemias	3.6%
64	Iron Overload	3.6%
65	Xanthoma	3.6%
66	Familial Hypophosphatemic Rickets	3.5%
67	Pseudohypoparathyroidism	3.1%
68	Obesity, Abdominal	3%
69	Brain Diseases, Metabolic, Inborn	2.9%
70	Diabetes Mellitus	2.6%
71	Dehydration	2.5%
72	Lipomatosis	2.5%
73	Water Intoxication	2.5%
74	Werner Syndrome	2.5%
75	Achlorhydria	2.5%
76	Amino Acid Metabolism, Inborn Errors	2.5%
77	Bloom Syndrome	2.5%
78	Carbohydrate Metabolism, Inborn Errors	2.5%
79	Metal Metabolism, Inborn Errors	2.5%
80	Osteoporosis	2.5%
81	Progeria	2.5%
82	Lysosomal Storage Diseases	2.5%
83	Bone Demineralization, Pathologic	2.5%
84	Cytochrome-c Oxidase Deficiency	2.5%
85	Peroxisomal Disorders	2.5%
86	Post-Traumatic Osteoporosis	2.5%
87	Celiac Disease	2.4%
88	Sprue, Tropical	2.4%
89	Steatorrhea	2.4%
90	Sprue	2.4%
91	Pediatric Obesity	2.4%
92	Lactose Intolerance	2.3%
93	Leigh Disease	2.2%
94	Prader-Willi Syndrome	2%
95	Hypolipoproteinemias	2%
96	Acidosis, Lactic	2%
97	Calciphylaxis	2%
98	Hemosiderosis	2%
99	Ketosis	2%
100	Ketonuria	2%
101	Ketoacidosis	2%
102	Ketonemia	2%
103	Vascular calcification	2%
104	Mitochondrial Encephalomyopathies	1.9%
105	Mitochondrial Myopathies	1.9%
106	Myelinolysis, Central Pontine	1.9%
107	Glycosuria	1.8%
108	Reye Syndrome	1.8%
109	Hepatic Encephalopathy	1.8%
110	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
111	Smith-Lemli-Opitz Syndrome	1.7%
112	Galactosemias	1.7%
113	Urea Cycle Disorders, Inborn	1.7%
114	Tyrosinemias	1.7%
115	Congenital Hyperinsulinism	1.7%
116	Diabetic Ketoacidosis	1.6%
117	Hyperlipidemia, Familial Combined	1.6%
118	Hyperphosphaturia	1.5%
119	Porphyrias, Hepatic	1.5%
120	Necrobiosis Lipoidica Diabeticorum	1.5%
121	Fanconi Anemia	1.5%
122	Hyperlipoproteinemia Type IV	1.4%
123	Hyperlipoproteinemia Type V	1.4%
124	Hyperlipoproteinemia Type III	1.4%
125	Acidosis, Respiratory	1.3%
126	Adiposis Dolorosa	1.3%
127	Alkalosis, Respiratory	1.3%
128	Renal tubular acidosis	1.3%
129	Alkaptonuria	1.3%
130	Glycogen Storage Disease	1.3%
131	Hypophosphatasia	1.3%
132	Insulin Resistance	1.3%
133	Osteoporosis, Postmenopausal	1.3%
134	Propionic acidemia	1.3%
135	Dihydropyrimidine Dehydrogenase Deficiency	1.3%
136	Cystinosis	1.3%
137	Homocystinuria	1.3%
138	Friedreich Ataxia	1.2%
139	Hypoalphalipoproteinemias	1.2%
140	Hypercholesterolemia	1.2%
141	Hyperlipoproteinemias	1.2%
142	Hypertriglyceridemia	1.2%
143	HIV-Associated Lipodystrophy Syndrome	1.2%
144	Zellweger Syndrome	1.1%
145	Amyloid Neuropathies, Familial	1.1%
146	Menkes Kinky Hair Syndrome	1.1%
147	Neuronal Ceroid-Lipofuscinoses	1.1%
148	Kernicterus	1.1%
149	Cockayne Syndrome	1.1%
150	Glycogen storage disease type II	1.1%
151	Gestational Diabetes	1.1%
152	Latent Autoimmune Diabetes in Adults	1.1%
153	MELAS Syndrome	1%
154	Diabetes Mellitus, Experimental	1%
155	Hepatolenticular Degeneration	1%
156	Nephrocalcinosis	1%
157	Tetany	1%
158	Refsum Disease	1%
159	Glycosuria, Renal	1%
160	Cerebral Amyloid Angiopathy	1%
161	Adrenoleukodystrophy	1%
162	Nesidioblastosis	1%
163	Ataxia Telangiectasia	0.9%
164	Optic Atrophy, Hereditary, Leber	0.9%
165	Kearns-Sayre syndrome	0.9%
166	Gaucher Disease	0.9%
167	Xeroderma Pigmentosum	0.8%
168	Familial Periodic Paralysis	0.8%
169	Primary amyloidosis	0.8%
170	Variegate Porphyria	0.8%
171	Acute intermittent porphyria	0.8%
172	Porphyria Cutanea Tarda	0.8%
173	Renal Aminoacidurias	0.8%
174	Fanconi Syndrome	0.8%
175	Pseudohypoaldosteronism	0.8%
176	Liddle Syndrome	0.8%
177	Mucopolysaccharidosis III	0.8%
178	Glycogen Storage Disease Type I	0.8%
179	Glycogen Storage Disease Type V	0.8%
180	Gout	0.7%
181	Amyotrophic Lateral Sclerosis	0.7%
182	Antley-Bixler Syndrome Phenotype	0.7%
183	Fabry Disease	0.7%
184	Sjogren-Larsson Syndrome	0.6%
185	CREST Syndrome	0.6%
186	Niemann-Pick Disease, Type C	0.6%
187	Canavan Disease	0.5%
188	Alexander Disease	0.5%
189	Mucopolysaccharidosis II	0.5%
190	Albinism	0.5%
191	Tay-Sachs Disease	0.5%
192	Hypokalemic periodic paralysis	0.5%
193	Frontotemporal dementia	0.5%
194	Cystinuria	0.5%
195	Ichthyosis, X-Linked	0.4%
196	Arthritis, Gouty	0.4%

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