MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Patellofemoral Pain Syndrome

(UMLS:C0877149)

Definition:: A syndrome characterized by retropatellar or peripatellar PAIN resulting from physical and biochemical changes in the patellofemoral joint. The pain is most prominent when ascending or descending stairs, squatting, or sitting with flexed knees. There is a lack of consensus on the etiology and treatment. The syndrome is often confused with (or accompanied by) CHONDROMALACIA PATELLAE, the latter describing a pathological condition of the CARTILAGE and not a syndrome.
UMLS ID:: C0877149
MeSH ID:: D046788

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.550.700

Synonym(s)

Patellofemoral Pain Syndrome

Patello femoral syndrome

Patellofemoral pain syndrome

pain patellofemoral syndrome

patellofemoral pain syndrome

patellofemoral syndrome

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 60	OFFSIDES US FAERS
2	Isotretinoin	FAERS: 26	US FAERS
3	rofecoxib	FAERS: 20	OFFSIDES US FAERS
4	NuvaRing	FAERS: 10	US FAERS
5	Finasteride	FAERS: 5	US FAERS
6	Levofloxacin	FAERS: 3	US FAERS
7	Paroxetine	FAERS: 3	US FAERS
8	Pregabalin	FAERS: 3	US FAERS
9	Medroxyprogesterone Acetate	FAERS: 2	US FAERS
10	tofacitinib	FAERS: 2	US FAERS
11	Celecoxib	FAERS: 1	US FAERS
12	Ciprofloxacin	FAERS: 1	US FAERS
13	Esomeprazole	FAERS: 1	US FAERS
14	Ondansetron	FAERS: 1	US FAERS
15	Quetiapine Fumarate	FAERS: 1	US FAERS
16	Tacrolimus	FAERS: 1	US FAERS
17	Tiotropium Bromide	FAERS: 1	US FAERS
18	adefovir dipivoxil	FAERS: 1	US FAERS
19	teriflunomide	FAERS: 1	US FAERS
20	Acetaminophen		OFFSIDES
21	Allopurinol		OFFSIDES
22	Bisacodyl		OFFSIDES
23	Bortezomib		OFFSIDES
24	Bupropion		OFFSIDES
25	Calcium Compounds		OFFSIDES
26	Cholesterol		OFFSIDES
27	Clopidogrel		OFFSIDES
28	D-Galactosamine		OFFSIDES
29	Desogestrel		OFFSIDES
30	Didanosine		OFFSIDES
31	Docusate sodium		OFFSIDES
32	Etodolac		OFFSIDES
33	Famciclovir		OFFSIDES
34	Hydron;carbonate		OFFSIDES
35	Hydroxyzine		OFFSIDES
36	Ipratropium		OFFSIDES
37	Isosorbide		OFFSIDES
38	Ketorolac Tromethamine		OFFSIDES
39	Lenalidomide		OFFSIDES
40	Letrozole		OFFSIDES
41	Loratadine		OFFSIDES
42	Memantine		OFFSIDES
43	Methocarbamol		OFFSIDES
44	Methyldopa		OFFSIDES
45	Methylphenidate		OFFSIDES
46	Metolazone		OFFSIDES
47	Minocycline		OFFSIDES
48	Moclobemide		OFFSIDES
49	Naproxen		OFFSIDES
50	Nelfinavir		OFFSIDES
51	Niacinamide		OFFSIDES
52	Oxymetazoline		OFFSIDES
53	Pamidronate		OFFSIDES
54	Penicillin V		OFFSIDES
55	Piperacillin, Tazobactam Drug Combination		OFFSIDES
56	Piroxicam		OFFSIDES
57	Pyridoxine		OFFSIDES
58	Quinapril		OFFSIDES
59	Rosuvastatin Calcium		OFFSIDES
60	Rosuvastatin Calcium		OFFSIDES
61	Scopolamine		OFFSIDES
62	Stavudine		OFFSIDES
63	Sulindac		OFFSIDES
64	Sumatriptan		OFFSIDES
65	Tenofovir		OFFSIDES
66	Tenofovir		OFFSIDES
67	Terbinafine		OFFSIDES
68	Toremifene		OFFSIDES
69	Tretinoin		OFFSIDES
70	Trifluoperazine		OFFSIDES
71	Urea		OFFSIDES
72	Valproic Acid		OFFSIDES
73	Zidovudine		OFFSIDES
74	Zoledronic Acid		OFFSIDES
75	calcium acetate		OFFSIDES
76	candesartan		OFFSIDES
77	cefprozil		OFFSIDES
78	chlorhexidine gluconate		OFFSIDES
79	cyclobenzaprine		OFFSIDES
80	efavirenz		OFFSIDES
81	exemestane		OFFSIDES
82	fexofenadine		OFFSIDES
83	frovatriptan		OFFSIDES
84	glimepiride		OFFSIDES
85	montelukast		OFFSIDES
86	montelukast		OFFSIDES
87	ropinirole		OFFSIDES
88	testosterone 17 beta-cypionate		OFFSIDES
89	tizanidine		OFFSIDES
90	zolmitriptan		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Arthritis	42.9%
2	Bursitis	42.9%
3	Joint Instability	42.9%
4	Synovitis	42.9%
5	Joint laxity	42.9%
6	Polyarthritis	42.9%
7	Frozen shoulder	42.9%
8	Periarthritis	40.9%
9	Contracture	38.1%
10	Osteoarthropathy, Secondary Hypertrophic	38.1%
11	Sacroiliitis	31%
12	Ankylosing spondylitis	29.5%
13	Arthrogryposis	28.2%
14	Hemarthrosis	27.9%
15	Metatarsalgia	27.8%
16	Hip Contracture	27.3%
17	Osteoarthritis, Spine	26.7%
18	Gout	24.7%
19	Osteoarthritis, Knee	23.6%
20	Arthritis, Psoriatic	23.5%
21	Bone Diseases	23.1%
22	Fasciitis	23.1%
23	Foot Deformities	23.1%
24	Rheumatic Fever	22.2%
25	Spondylarthropathies	21.5%
26	Arthritis, Reactive	21.5%
27	Arthritis, Infectious	20.9%
28	Arthritis, Experimental	20.5%
29	Temporomandibular Joint Disorders	20.3%
30	Ischemic contracture	20.3%
31	Arthritis, Gouty	19.7%
32	Fasciitis, Plantar	19%
33	Rheumatoid Arthritis	18.1%
34	Juvenile arthritis	18.1%
35	Rheumatoid Nodule	17.5%
36	Nail-Patella Syndrome	16.7%
37	Arthralgia	16.1%
38	Polyarthralgia	16.1%
39	Temporomandibular Joint Dysfunction Syndrome	16%
40	Hip Dislocation	15.8%
41	Jaw Diseases	15.8%
42	Shoulder Dislocation	15.8%
43	Hip Dysplasia	15.8%
44	Cartilage Diseases	15%
45	Foot Diseases	15%
46	Myopathy	15%
47	Rheumatism	15%
48	Chondromalacia	15%
49	Bone Diseases, Developmental	14.3%
50	Hyperostosis	14.3%
51	Myofascial Pain Syndromes	14.3%
52	Osteitis	14.3%
53	Osteitis Deformans	14.3%
54	Osteochondrosis	14.3%
55	Rhabdomyolysis	14.3%
56	Spinal Diseases	14.3%
57	Fibromyalgia	14%
58	Osteochondritis	14%
59	Polymyalgia Rheumatica	14%
60	Felty Syndrome	14%
61	Pectus carinatum	12.6%
62	Platybasia	12.1%
63	Pectus excavatum	12.1%
64	Shoulder Pain	11.8%
65	Rheumatoid Vasculitis	11.6%
66	Klippel-Feil Syndrome	11.1%
67	Synostosis	11.1%
68	Talipes	10.9%
69	Ainhum	10.3%
70	Bunion	10.3%
71	Dysostoses	10.3%
72	Fibrodysplasia Ossificans Progressiva	10.3%
73	Myoglobinuria	10.3%
74	Myositis Ossificans	10.3%
75	Spinal Stenosis	10.3%
76	Spondylosis	10.3%
77	Tenosynovitis	10.3%
78	Intervertebral Disc Degeneration	10.3%
79	Gigantism	10.2%
80	Spinal Neoplasms	10.2%
81	Spondylitis	10.2%
82	Bone Diseases, Endocrine	10%
83	Sicca Syndrome	10%
84	Sjogren's Syndrome	10%
85	Bone Diseases, Infectious	9.5%
86	Bone neoplasms	9.5%
87	Compartment syndromes	9.5%
88	Maxillary Diseases	9.5%
89	Osteopenia	9.5%
90	Tendinitis	9.5%
91	Tendinopathy	9.5%
92	Bone Resorption	9.3%
93	Myositis	9.3%
94	Tietze's Syndrome	9.3%
95	Limb Deformities, Congenital	9.3%
96	Isaacs syndrome	9.3%
97	Craniofacial Abnormalities	9.3%
98	Aseptic Necrosis of Bone	9.3%
99	Myotonic Disorders	9.3%
100	Congenital clubfoot	9.3%
101	Vertical Talus	9.3%
102	Craniofacial Dysostosis	9.2%
103	Craniosynostosis	9.1%
104	Syndactyly	9.1%
105	Brachycephaly	9.1%
106	Chondrodysplasia Punctata	8.5%
107	Enchondromatosis	8.5%
108	Lordosis	8.5%
109	Osteosclerosis	8.5%
110	Spondylolysis	8.5%
111	kyphosis	8.5%
112	Kashin-Beck Disease	8.5%
113	Acrocephalosyndactylia	8.3%
114	Discitis	8.3%
115	Poland Syndrome	7.7%
116	Melorheostosis	7.6%
117	Osteopetrosis	7.6%
118	Spondylolisthesis	7.6%
119	Goldenhar Syndrome	7.1%
120	Medial Tibial Stress Syndrome	7%
121	Multiple Epiphyseal Dysplasia	7%
122	Osteochondrodysplasias	7%
123	Mitochondrial Myopathies	6.9%
124	Muscle Cramp	6.8%
125	Eosinophilia-Myalgia Syndrome	6.8%
126	Gastroschisis	6.8%
127	Anterior Compartment Syndrome	6.8%
128	Osteomyelitis	6.8%
129	Osteoporosis	6.8%
130	Periostitis	6.8%
131	Enthesopathy	6.8%
132	Bone Demineralization, Pathologic	6.8%
133	Post-Traumatic Osteoporosis	6.8%
134	Abdominal Compartment Syndrome	6.8%
135	Muscle Rigidity	6.8%
136	Muscle Spasticity	6.8%
137	Cogwheel Rigidity	6.8%
138	Nuchal Rigidity	6.8%
139	Alveolar Bone Loss	6.7%
140	Amelia	6.7%
141	Arachnodactyly	6.7%
142	Ectromelia	6.7%
143	Femur Head Necrosis	6.7%
144	Hemimelia	6.7%
145	Phocomelia	6.7%
146	Sirenomelia	6.7%
147	Polymyositis	6.7%
148	Polydactyly	6.7%
149	Brachydactyly	6.7%
150	Plagiocephaly	6.7%
151	Lower Extremity Deformities, Congenital	6.7%
152	Upper Extremity Deformities, Congenital	6.7%
153	Osteolysis	6.7%
154	Tuberculosis, Spinal	6.5%
155	Jaw Abnormalities	6.3%
156	Mandibulofacial Dysostosis	6.2%
157	Congenital Hypothyroidism	6.2%
158	Prognathism	6%
159	Chronic Fatigue Syndrome	5.8%
160	Antley-Bixler Syndrome Phenotype	5.8%
161	Osteoporosis, Postmenopausal	5.6%
162	Giant Cell Epulis	5.5%
163	Muscle Weakness	5.5%
164	Dwarfism	5.5%
165	Musculoskeletal Pain	5.4%
166	Familial Periodic Paralysis	5.4%
167	Muscular Dystrophy	5.1%
168	Orbital Myositis	5.1%
169	Dupuytren Contracture	5.1%
170	Pyomyositis	5%
171	Acromegaly	5%
172	Joint Tuberculosis	5%
173	Tuberculosis, Osteoarticular	5%
174	Bone Tuberculosis	5%
175	Palatal Neoplasms	5%
176	Micrognathism	4.9%
177	Pierre Robin Syndrome	4.9%
178	Laryngomalacia	4.7%
179	Rubinstein-Taybi Syndrome	4.6%
180	Myotonic Dystrophy	4.6%
181	Eosinophilic Granuloma	4.5%
182	Myalgia	4.5%
183	Retrognathia	4.3%
184	Osteogenesis Imperfecta	4.3%
185	Welander Distal Myopathy	4.1%
186	Mastoiditis	4.1%
187	Petrositis	4.1%
188	Maxillofacial Abnormalities	4.1%
189	Myotonia Congenita	4%
190	Rickets	4%
191	Bronchomalacia	4%
192	Tracheomalacia	4%
193	Microcephaly	4%
194	Macrocephaly	4%
195	Hypokalemic periodic paralysis	3.9%
196	Basal Cell Nevus Syndrome	3.6%
197	Cleft Palate	3.4%
198	Dermatomyositis	3.4%
199	Pseudohypoparathyroidism	3.3%
200	Muscular Dystrophy, Duchenne	3.3%
201	Mitochondrial Encephalomyopathies	3.3%
202	Osteomalacia	3.3%
203	Porencephaly	3.3%
204	Noonan Syndrome	2.9%
205	Marfan Syndrome	2.6%
206	Holoprosencephaly	2.5%
207	Radicular Cyst	2.4%
208	Cockayne Syndrome	2.4%
209	Nose Neoplasms	2.1%
210	Renal Osteodystrophy	2%
211	Renal rickets	2%
212	MELAS Syndrome	1.6%
213	Kearns-Sayre syndrome	1.5%
214	Familial Hypophosphatemic Rickets	1.1%

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